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Cheap flights from Detroit Metropolitan Wayne County Airport to Florence from $333

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to Florence departing on 1/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:17 pm - 10:43 pm
DTW
-
FLO
4h 26m1 stop
American Airlines Logo
5:36 pm - 9:58 pm
FLO
-
DTW
4h 22m1 stop
$333American Airlines
Wed, Jan 14 - Sat, Jan 24
American Airlines Logo
7:58 pm - 12:15 am
DTW
-
FLO
4h 17m1 stop
American Airlines Logo
6:30 pm - 12:44 am
FLO
-
DTW
6h 14m1 stop
$335American Airlines
Tue, Dec 30 - Sat, Jan 3
American Airlines Logo
12:51 pm - 5:09 pm
DTW
-
FLO
4h 18m1 stop
American Airlines Logo
6:15 am - 1:32 pm
FLO
-
DTW
7h 17m2 stops
$338American Airlines
Sat, Jan 17 - Tue, Jan 20
American Airlines Logo
8:43 am - 5:09 pm
DTW
-
FLO
8h 26m2 stops
American Airlines Logo
6:15 am - 1:32 pm
FLO
-
DTW
7h 17m2 stops
$343American Airlines
Sat, Jan 17 - Tue, Jan 20
American Airlines Logo
6:17 pm - 10:43 pm
DTW
-
FLO
4h 26m1 stop
American Airlines Logo
6:15 am - 12:23 pm
FLO
-
DTW
6h 08m1 stop
$353American Airlines
Wed, Jan 14 - Fri, Jan 23
American Airlines Logo
2:02 pm - 11:11 pm
DTW
-
FLO
9h 09m2 stops
American Airlines Logo
6:15 am - 12:23 pm
FLO
-
DTW
6h 08m1 stop
$358American Airlines
Sat, Jan 17 - Sun, Jan 18
American Airlines Logo
4:01 pm - 10:43 pm
DTW
-
FLO
6h 42m2 stops
American Airlines Logo
6:15 am - 1:32 pm
FLO
-
DTW
7h 17m2 stops
$363American Airlines
Thu, Jan 15 - Tue, Jan 20
American Airlines Logo
6:17 pm - 10:43 pm
DTW
-
FLO
4h 26m1 stop
American Airlines Logo
6:15 am - 10:46 am
FLO
-
DTW
4h 31m1 stop
$369American Airlines
Tue, Jan 13 - Wed, Jan 21
American Airlines Logo
6:17 pm - 10:43 pm
DTW
-
FLO
4h 26m1 stop
American Airlines Logo
5:36 pm - 11:43 pm
FLO
-
DTW
6h 07m1 stop
$373American Airlines
Thu, Jan 15 - Thu, Jan 22
American Airlines Logo
8:00 am - 5:09 pm
DTW
-
FLO
9h 09m2 stops
American Airlines Logo
5:36 pm - 9:58 pm
FLO
-
DTW
4h 22m1 stop
$374American Airlines
Tue, Jan 13 - Sat, Jan 24

American Airlines flights from Detroit Metropolitan Wayne County Airport to Florence, South Carolina

Our best American Airlines deals on Detroit Metropolitan Wayne County Airport to Florence, South Carolina flight tickets
American Airlines
Jan 14
DTW6:17 pmDetroit Metropolitan Wayne County
4h 26m
1 stop
FLO10:43 pmFlorence
Jan 24
FLO5:36 pmFlorence
4h 22m
1 stop
DTW9:58 pmDetroit Metropolitan Wayne County
$333
Find similar
American Airlines
Dec 30
DTW7:58 pmDetroit Metropolitan Wayne County
4h 17m
1 stop
FLO12:15 amFlorence
Jan 3
FLO6:30 pmFlorence
6h 14m
1 stop
DTW12:44 amDetroit Metropolitan Wayne County
$335
Find similar
American Airlines
Jan 17
DTW12:51 pmDetroit Metropolitan Wayne County
4h 18m
1 stop
FLO5:09 pmFlorence
Jan 20
FLO6:15 amFlorence
7h 17m
2 stops
DTW1:32 pmDetroit Metropolitan Wayne County
$338
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 17, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 1/14

6:17 pm-10:43 pm

1 stop4h 26m

Florence

Sat 1/24

5:36 pm-9:58 pm

1 stop4h 22m

$333

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 12/30

7:58 pm-12:15 am

1 stop4h 17m

Florence

Sat 1/3

6:30 pm-12:44 am

1 stop6h 14m

$335

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 1/17

12:51 pm-5:09 pm

1 stop4h 18m

Florence

Tue 1/20

6:15 am-1:32 pm

2 stops7h 17m

$338

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 1/17

8:43 am-5:09 pm

2 stops8h 26m

Florence

Tue 1/20

6:15 am-1:32 pm

2 stops7h 17m

$343

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 1/14

6:17 pm-10:43 pm

1 stop4h 26m

Florence

Fri 1/23

6:15 am-12:23 pm

1 stop6h 08m

$353

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 1/17

2:02 pm-11:11 pm

2 stops9h 09m

Florence

Sun 1/18

6:15 am-12:23 pm

1 stop6h 08m

$358

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 1/15

4:01 pm-10:43 pm

2 stops6h 42m

Florence

Tue 1/20

6:15 am-1:32 pm

2 stops7h 17m

$363

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 1/13

6:17 pm-10:43 pm

1 stop4h 26m

Florence

Wed 1/21

6:15 am-10:46 am

1 stop4h 31m

$369

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 1/15

6:17 pm-10:43 pm

1 stop4h 26m

Florence

Thu 1/22

5:36 pm-11:43 pm

1 stop6h 07m

$373

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 1/13

8:00 am-5:09 pm

2 stops9h 09m

Florence

Sat 1/24

5:36 pm-9:58 pm

1 stop4h 22m

$374

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Florence, South Carolina?

On average, the least expensive day to fly to Florence, South Carolina from Detroit Metropolitan Wayne County Airport is on a Thursday. momondo users have found tickets for Thursday departures for as low as $360. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Friday is the most expensive day to depart from Detroit Metropolitan Wayne County Airport because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $387.

When to book flights from Detroit Metropolitan Wayne County Airport to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit Metropolitan Wayne County Airport to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit Metropolitan Wayne County Airport to Florence, South Carolina (DTW to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina

Fastest flight time

4h 17m

Direct flights

None
The fastest flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina takes 4h 17m
There are no direct flights from Detroit Metropolitan Wayne County Airport to Florence, South Carolina. There are no popular flight routes from Detroit Metropolitan Wayne County Airport to Florence, South Carolina.
Search flight deals

  • How far is Detroit Metropolitan Wayne County to Florence by plane?

    The distance between Detroit Metropolitan Wayne County and Florence is about 587.3 mi. Typically, this will take 4h 17m by plane in normal conditions.

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to Florence Airport?

    Prices for flights from Detroit Metropolitan Wayne County Airport to Florence Airport refresh daily.

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit Metropolitan Wayne County Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The required travel and health documents for your Florence Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Detroit to Florence for you.

Can I find flights from Detroit to Florence with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Detroit to Florence flights to just show those with flexible booking policies.

How can momondo help me find flights from Detroit to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Detroit to Florence.

I’m not ready to book a flight from Detroit to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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