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Cheap flights from Detroit Metropolitan Wayne County Airport to Florence from $409

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to Florence departing on 2/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:54 pm - 11:57 pm
DTW
-
FLO
4h 03m
1 stop
American Airlines Logo
6:20 pm - 12:38 am
FLO
-
DTW
6h 18m
1 stop
$409American Airlines
Thu, Feb 26 - Mon, Mar 2
American Airlines Logo
7:54 pm - 11:57 pm
DTW
-
FLO
4h 03m
1 stop
American Airlines Logo
5:16 am - 4:48 pm
FLO
-
DTW
11h 32m
2 stops
$414American Airlines
Thu, Feb 26 - Mon, Mar 2
American Airlines Logo
10:01 am - 2:10 pm
DTW
-
FLO
4h 09m
1 stop
American Airlines Logo
2:35 pm - 7:18 pm
FLO
-
DTW
4h 43m
1 stop
$449American Airlines
Thu, May 21 - Mon, May 25
American Airlines Logo
6:00 am - 2:10 pm
DTW
-
FLO
8h 10m
2 stops
American Airlines Logo
2:35 pm - 7:18 pm
FLO
-
DTW
4h 43m
1 stop
$479American Airlines
Thu, May 21 - Mon, May 25
American Airlines Logo
10:01 am - 5:50 pm
DTW
-
FLO
7h 49m
2 stops
American Airlines Logo
5:16 am - 4:48 pm
FLO
-
DTW
11h 32m
2 stops
$539American Airlines
Thu, Feb 26 - Mon, Mar 2
American Airlines Logo
6:00 am - 2:10 pm
DTW
-
FLO
8h 10m
2 stops
American Airlines Logo
2:35 pm - 11:57 pm
FLO
-
DTW
9h 22m
2 stops
$624American Airlines
Thu, May 21 - Mon, May 25
American Airlines Logo
11:55 am - 5:50 pm
DTW
-
FLO
5h 55m
1 stop
American Airlines Logo
5:58 pm - 9:53 pm
FLO
-
DTW
3h 55m
1 stop
$861American Airlines
Sun, Mar 15 - Tue, Mar 17

American Airlines flights from Detroit Metropolitan Wayne County Airport to Florence, South Carolina

Our best American Airlines deals on Detroit Metropolitan Wayne County Airport to Florence, South Carolina flight tickets
American Airlines
Feb 19
DTW11:55 amDetroit Metropolitan Wayne County
5h 55m
1 stop
FLO5:50 pmFlorence
Feb 22
FLO6:20 pmFlorence
6h 18m
1 stop
DTW12:38 amDetroit Metropolitan Wayne County
$409
American Airlines
Feb 19
DTW1:02 pmDetroit Metropolitan Wayne County
10h 55m
2 stops
FLO11:57 pmFlorence
Feb 22
FLO5:16 amFlorence
5h 38m
1 stop
DTW10:54 amDetroit Metropolitan Wayne County
$414
American Airlines
May 21
DTW10:01 amDetroit Metropolitan Wayne County
4h 09m
1 stop
FLO2:10 pmFlorence
May 25
FLO2:35 pmFlorence
4h 43m
1 stop
DTW7:18 pmDetroit Metropolitan Wayne County
$449

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 13, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 2/26

7:54 pm-11:57 pm

1 stop4h 03m

Florence

Mon 3/2

6:20 pm-12:38 am

1 stop6h 18m

$409

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 2/26

7:54 pm-11:57 pm

1 stop4h 03m

Florence

Mon 3/2

5:16 am-4:48 pm

2 stops11h 32m

$414

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 5/21

10:01 am-2:10 pm

1 stop4h 09m

Florence

Mon 5/25

2:35 pm-7:18 pm

1 stop4h 43m

$449

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 5/21

6:00 am-2:10 pm

2 stops8h 10m

Florence

Mon 5/25

2:35 pm-7:18 pm

1 stop4h 43m

$479

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 2/26

10:01 am-5:50 pm

2 stops7h 49m

Florence

Mon 3/2

5:16 am-4:48 pm

2 stops11h 32m

$539

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 5/21

6:00 am-2:10 pm

2 stops8h 10m

Florence

Mon 5/25

2:35 pm-11:57 pm

2 stops9h 22m

$624

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sun 3/15

11:55 am-5:50 pm

1 stop5h 55m

Florence

Tue 3/17

5:58 pm-9:53 pm

1 stop3h 55m

$861

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

Delta, Spirit Airlines and American Airlines are the top three most popular airlines that fly to Florence, South Carolina from Detroit Metropolitan Wayne County Airport according to our data. Delta is the first choice among our users, with 44% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 5 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Detroit Metropolitan Wayne County Airport to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit Metropolitan Wayne County Airport to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit Metropolitan Wayne County Airport to Florence, South Carolina (DTW to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina

Fastest flight time

4h 02m

Direct flights

None
The fastest flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina takes 4h 02m
There are no direct flights from Detroit Metropolitan Wayne County Airport to Florence, South Carolina. There are no popular flight routes from Detroit Metropolitan Wayne County Airport to Florence, South Carolina.
Search flight deals

  • How far is Detroit Metropolitan Wayne County to Florence by plane?

    The distance between Detroit Metropolitan Wayne County and Florence is about 587.3 mi. Typically, this will take 4h 02m by plane in normal conditions.

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to Florence Airport?

    Prices for flights from Detroit Metropolitan Wayne County Airport to Florence Airport refresh daily.

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit Metropolitan Wayne County Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The required travel and health documents for your Florence Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Darlington
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Detroit to Florence for you.

Can I find flights from Detroit to Florence with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Detroit to Florence flights to just show those with flexible booking policies.

How can momondo help me find flights from Detroit to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Detroit to Florence.

I’m not ready to book a flight from Detroit to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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