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Cheap flights from Detroit Metropolitan Wayne County Airport to Florence from $491

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to Florence departing on 1/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Detroit Metropolitan Wayne County Airport to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:03 pm - 10:43 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
5h 40m1 stop Charlotte Douglas
American Airlines Logo
5:24 am - 11:17 amFLO  Florence-DTW Detroit Metropolitan Wayne County
5h 53m1 stop Charlotte Douglas
$491American Airlines
Wed, Jan 20 - Sat, May 8
American Airlines Logo
10:05 am - 2:09 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
4h 04m1 stop Charlotte Douglas
American Airlines Logo
6:30 am - 10:26 amFLO  Florence-DTW Detroit Metropolitan Wayne County
3h 56m1 stop Charlotte Douglas
$491American Airlines
Sat, Oct 17 - Tue, Oct 20
American Airlines Logo
6:48 am - 5:09 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
10h 21m2 stops Chicago O'Hare Intl Charlotte Douglas
American Airlines Logo
4:16 pm - 10:34 pmFLO  Florence-DTW Detroit Metropolitan Wayne County
6h 18m1 stop Charlotte Douglas
$504American Airlines
Wed, Jan 20 - Sat, May 8
American Airlines Logo
10:22 am - 11:57 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
13h 35m2 stops Chicago O'Hare Intl Charlotte Douglas
American Airlines Logo
3:19 pm - 10:07 pmFLO  Florence-DTW Detroit Metropolitan Wayne County
6h 48m1 stop Charlotte Douglas
$504American Airlines
Sat, Oct 17 - Tue, Oct 20
American Airlines Logo
1:08 pm - 5:09 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
4h 01m1 stop Charlotte Douglas
American Airlines Logo
6:15 am - 8:06 pmFLO  Florence-DTW Detroit Metropolitan Wayne County
13h 51m2 stops Charlotte Douglas Chicago O'Hare Intl
$504American Airlines
Wed, Jan 27 - Mon, Feb 1
American Airlines Logo
6:48 am - 5:09 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
10h 21m2 stops Chicago O'Hare Intl Charlotte Douglas
American Airlines Logo
6:15 am - 8:06 pmFLO  Florence-DTW Detroit Metropolitan Wayne County
13h 51m2 stops Charlotte Douglas Chicago O'Hare Intl
$517American Airlines
Wed, Jan 27 - Mon, Feb 1
American Airlines Logo
10:22 am - 11:57 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
13h 35m2 stops Chicago O'Hare Intl Charlotte Douglas
American Airlines Logo
6:30 am - 8:05 pmFLO  Florence-DTW Detroit Metropolitan Wayne County
13h 35m2 stops Charlotte Douglas Chicago O'Hare Intl
$518American Airlines
Sat, Oct 17 - Tue, Oct 20
American Airlines Logo
11:30 am - 5:09 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
5h 39m1 stop Charlotte Douglas
American Airlines Logo
6:15 am - 10:40 amFLO  Florence-DTW Detroit Metropolitan Wayne County
4h 25m1 stop Charlotte Douglas
$528American Airlines
Wed, Jan 27 - Mon, Feb 1
American Airlines Logo
10:05 am - 2:09 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
4h 04m1 stop Charlotte Douglas
American Airlines Logo
5:35 pm - 9:54 pmFLO  Florence-DTW Detroit Metropolitan Wayne County
4h 19m1 stop Charlotte Douglas
$528American Airlines
Fri, Oct 9 - Sat, Jan 23
American Airlines Logo
4:59 pm - 11:57 pmDTW  Detroit Metropolitan Wayne County-FLO Florence
6h 58m1 stop Charlotte Douglas
American Airlines Logo
5:09 am - 4:09 pmFLO  Florence-DTW Detroit Metropolitan Wayne County
11h 00m2 stops Charlotte Douglas Chicago O'Hare Intl
$541American Airlines
Thu, Oct 8 - Thu, Oct 22

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American Airlines flights from Detroit Metropolitan Wayne County Airport to Florence, South Carolina

Our best American Airlines deals on Detroit Metropolitan Wayne County Airport to Florence, South Carolina flight tickets
American Airlines
Oct 17
DTW10:05 amDetroit Metropolitan Wayne County
4h 04m
1 stop
FLO2:09 pmFlorence
Oct 20
FLO6:30 amFlorence
3h 56m
1 stop
DTW10:26 amDetroit Metropolitan Wayne County
$491
American Airlines
Oct 17
DTW10:22 amDetroit Metropolitan Wayne County
13h 35m
2 stops
FLO11:57 pmFlorence
Oct 20
FLO3:19 pmFlorence
6h 48m
1 stop
DTW10:07 pmDetroit Metropolitan Wayne County
$504
American Airlines
Jan 27
DTW6:48 amDetroit Metropolitan Wayne County
10h 21m
2 stops
FLO5:09 pmFlorence
Feb 1
FLO6:15 amFlorence
13h 51m
2 stops
DTW8:06 pmDetroit Metropolitan Wayne County
$517

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 15, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Wed 1/20

5:03 pm-10:43 pm

1 stop5h 40m

Florence

Sat 5/8

5:24 am-11:17 am

1 stop5h 53m

$491
Quickest round-trip

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Sat 10/17

10:05 am-2:09 pm

1 stop4h 04m

Florence

Tue 10/20

6:30 am-10:26 am

1 stop3h 56m

$491

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Wed 1/20

6:48 am-5:09 pm

2 stops10h 21m

Florence

Sat 5/8

4:16 pm-10:34 pm

1 stop6h 18m

$504

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Sat 10/17

10:22 am-11:57 pm

2 stops13h 35m

Florence

Tue 10/20

3:19 pm-10:07 pm

1 stop6h 48m

$504

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Wed 1/27

1:08 pm-5:09 pm

1 stop4h 01m

Florence

Mon 2/1

6:15 am-8:06 pm

2 stops13h 51m

$504

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Wed 1/27

6:48 am-5:09 pm

2 stops10h 21m

Florence

Mon 2/1

6:15 am-8:06 pm

2 stops13h 51m

$517

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Sat 10/17

10:22 am-11:57 pm

2 stops13h 35m

Florence

Tue 10/20

6:30 am-8:05 pm

2 stops13h 35m

$518

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Wed 1/27

11:30 am-5:09 pm

1 stop5h 39m

Florence

Mon 2/1

6:15 am-10:40 am

1 stop4h 25m

$528

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Fri 10/9

10:05 am-2:09 pm

1 stop4h 04m

Florence

Sat 1/23

5:35 pm-9:54 pm

1 stop4h 19m

$528

DetroitFlorence

DTW Detroit Metropolitan Wayne County - FLO Florence

DTWFLO

Detroit Metropolitan Wayne County

Thu 10/8

4:59 pm-11:57 pm

1 stop6h 58m

Florence

Thu 10/22

5:09 am-4:09 pm

2 stops11h 00m

$541

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Detroit Metropolitan Wayne County Airport to Florence, South Carolina flights?

You could potentially save up to 34% on your flight if you consider stops on a Detroit Metropolitan Wayne County Airport to Florence, South Carolina flight.

When to book flights from Detroit Metropolitan Wayne County Airport to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit Metropolitan Wayne County Airport to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit Metropolitan Wayne County Airport to Florence, South Carolina (DTW to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina

Fastest flight time

4h 04m

Direct flights

None
The fastest flight from Detroit Metropolitan Wayne County Airport to Florence, South Carolina takes 4h 04m
There are no direct flights from Detroit Metropolitan Wayne County Airport to Florence, South Carolina. There are no popular flight routes from Detroit Metropolitan Wayne County Airport to Florence, South Carolina.
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Frequently asked questions about flying from Detroit Metropolitan Wayne County Airport to Florence, South Carolina

  • How far is Detroit Metropolitan Wayne County to Florence by plane?

    The distance between Detroit Metropolitan Wayne County and Florence is about 587.3 mi. Typically, this will take 4h 04m by plane in normal conditions.

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to Florence Airport?

    Prices for flights from Detroit Metropolitan Wayne County Airport to Florence Airport refresh daily.

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit Metropolitan Wayne County Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The required travel and health documents for your Florence Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Detroit to Florence for you.

Can I find flights from Detroit to Florence with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Detroit to Florence flights to just show those with flexible booking policies.

How can momondo help me find flights from Detroit to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Detroit to Florence.

I’m not ready to book a flight from Detroit to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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