What airlines fly to Syracuse?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Syracuse from Des Moines according to our data. American Airlines is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Syracuse. Keep in mind that there are 3 different airlines that fly to Syracuse on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to Syracuse Hancock Intl Airport?

Prices for flights from Des Moines Airport to Syracuse Hancock Intl Airport refresh daily.

How many operators does momondo search for flights from Des Moines Airport to Syracuse Hancock Intl Airport?

The number of operators available for flights from Des Moines Airport to Syracuse Hancock Intl Airport is 3 as of October 2026.

How old do you have to be to fly from Des Moines Airport to Syracuse Hancock Intl Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Syracuse Hancock Intl Airport.

What documentation or ID do you need to fly to Syracuse Hancock Intl Airport?

The travel and health documents you'll need for your trip to Syracuse Hancock Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Syracuse Hancock Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$349 Cheap Flights from Des Moines to Syracuse in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Syracuse

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

1:27 pm - 10:53 pmDSM Des Moines-SYR Syracuse Hancock Intl

8h 26m1 stop Denver Intl

6:00 am - 10:32 amSYR Syracuse Hancock Intl-DSM Des Moines

5h 32m1 stop Chicago O'Hare Intl

$349United Airlines

Fri, Nov 13 - Sun, Nov 15

1:58 pm - 11:39 pmDSM Des Moines-SYR Syracuse Hancock Intl

8h 41m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National

6:40 pm - 12:26 amSYR Syracuse Hancock Intl-DSM Des Moines

6h 46m1 stop Chicago O'Hare Intl

$354American Airlines

Fri, Nov 13 - Sun, Nov 15

7:23 am - 4:59 pmDSM Des Moines-SYR Syracuse Hancock Intl

8h 36m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National

5:33 pm - 10:39 pmSYR Syracuse Hancock Intl-DSM Des Moines

6h 06m1 stop Washington, D.C. Reagan-National

$379American Airlines

Thu, Nov 5 - Mon, Nov 9

7:23 am - 4:59 pmDSM Des Moines-SYR Syracuse Hancock Intl

8h 36m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National

5:33 pm - 12:26 amSYR Syracuse Hancock Intl-DSM Des Moines

7h 53m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl

$385American Airlines

Thu, Nov 5 - Mon, Nov 9

9:50 am - 4:39 pmDSM Des Moines-SYR Syracuse Hancock Intl

5h 49m1 stop Chicago O'Hare Intl

5:20 pm - 9:55 pmSYR Syracuse Hancock Intl-DSM Des Moines

5h 35m1 stop Chicago O'Hare Intl

$414United Airlines

Thu, Nov 5 - Mon, Nov 9

5:29 pm - 10:54 pmDSM Des Moines-SYR Syracuse Hancock Intl

4h 25m1 stop Detroit Metropolitan Wayne County

5:10 pm - 8:39 pmSYR Syracuse Hancock Intl-DSM Des Moines

4h 29m1 stop Detroit Metropolitan Wayne County

$444Delta

Wed, Nov 25 - Wed, Dec 2

5:29 pm - 10:54 pmDSM Des Moines-SYR Syracuse Hancock Intl

4h 25m1 stop Detroit Metropolitan Wayne County

6:00 am - 9:50 amSYR Syracuse Hancock Intl-DSM Des Moines

4h 50m1 stop Detroit Metropolitan Wayne County

$444Delta

Fri, Nov 27 - Tue, Dec 1

1:35 pm - 11:43 pmDSM Des Moines-SYR Syracuse Hancock Intl

9h 08m1 stop Denver Intl

5:24 pm - 11:14 pmSYR Syracuse Hancock Intl-DSM Des Moines

6h 50m1 stop Chicago O'Hare Intl

$449United Airlines

Wed, Jan 27 - Sat, Jan 30

3:11 pm - 9:07 amDSM Des Moines-SYR Syracuse Hancock Intl

16h 56m1 stop Fort Myers SW Florida Intl

7:29 pm - 7:35 pmSYR Syracuse Hancock Intl-DSM Des Moines

25h 06m2 stops Tampa Denver Intl

$652Multiple Airlines

Fri, Nov 6 - Sun, Nov 8

7:00 am - 11:29 amDSM Des Moines-SYR Syracuse Hancock Intl

27h 29m1 stop Sarasota Bradenton Intl

12:24 pm - 10:29 pmSYR Syracuse Hancock Intl-DSM Des Moines

11h 05m2 stops Raleigh-Durham Sarasota Bradenton Intl

$873Multiple Airlines

Tue, Nov 24 - Mon, Nov 30

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Delta flights from Des Moines to Syracuse

Our best Delta deals on Des Moines to Syracuse flight tickets

Delta

Dec 22

DSM6:11 pmDes Moines

4h 02m

1 stop

SYR11:13 pmSyracuse Hancock Intl

Dec 29

SYR6:00 amSyracuse Hancock Intl

4h 55m

1 stop

DSM9:55 amDes Moines

$369

Delta

Nov 25

DSM5:29 pmDes Moines

4h 25m

1 stop

SYR10:54 pmSyracuse Hancock Intl

Dec 2

SYR5:10 pmSyracuse Hancock Intl

4h 29m

1 stop

DSM8:39 pmDes Moines

$444

Delta

Oct 30

DSM3:46 pmDes Moines

6h 43m

1 stop

SYR11:29 pmSyracuse Hancock Intl

Nov 2

SYR5:20 pmSyracuse Hancock Intl

4h 20m

1 stop

DSM8:40 pmDes Moines

$484

American Airlines flights from Des Moines to Syracuse

Our best American Airlines deals on Des Moines to Syracuse flight tickets

American Airlines

Nov 13

DSM1:58 pmDes Moines

8h 41m

2 stops

SYR11:39 pmSyracuse Hancock Intl

Nov 15

SYR6:40 pmSyracuse Hancock Intl

6h 46m

1 stop

DSM12:26 amDes Moines

$354

American Airlines

Nov 5

DSM7:23 amDes Moines

8h 36m

2 stops

SYR4:59 pmSyracuse Hancock Intl

Nov 9

SYR5:33 pmSyracuse Hancock Intl

6h 06m

1 stop

DSM10:39 pmDes Moines

$379

American Airlines

Nov 5

DSM7:23 amDes Moines

8h 36m

2 stops

SYR4:59 pmSyracuse Hancock Intl

Nov 9

SYR5:33 pmSyracuse Hancock Intl

7h 53m

2 stops

DSM12:26 amDes Moines

$385

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Fri 11/13

1:27 pm-10:53 pm

1 stop8h 26m

Syracuse Hancock Intl

Sun 11/15

6:00 am-10:32 am

1 stop5h 32m

$349

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Fri 11/13

1:58 pm-11:39 pm

2 stops8h 41m

Syracuse Hancock Intl

Sun 11/15

6:40 pm-12:26 am

1 stop6h 46m

$354

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Thu 11/5

7:23 am-4:59 pm

2 stops8h 36m

Syracuse Hancock Intl

Mon 11/9

5:33 pm-10:39 pm

1 stop6h 06m

$379

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Thu 11/5

7:23 am-4:59 pm

2 stops8h 36m

Syracuse Hancock Intl

Mon 11/9

5:33 pm-12:26 am

2 stops7h 53m

$385

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Thu 11/5

9:50 am-4:39 pm

1 stop5h 49m

Syracuse Hancock Intl

Mon 11/9

5:20 pm-9:55 pm

1 stop5h 35m

$414

Quickest round-trip

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Wed 11/25

5:29 pm-10:54 pm

1 stop4h 25m

Syracuse Hancock Intl

Wed 12/2

5:10 pm-8:39 pm

1 stop4h 29m

$444

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Fri 11/27

5:29 pm-10:54 pm

1 stop4h 25m

Syracuse Hancock Intl

Tue 12/1

6:00 am-9:50 am

1 stop4h 50m

$444

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Wed 1/27

1:35 pm-11:43 pm

1 stop9h 08m

Syracuse Hancock Intl

Sat 1/30

5:24 pm-11:14 pm

1 stop6h 50m

$449

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Fri 11/6

3:11 pm-9:07 am

1 stop16h 56m

Syracuse Hancock Intl

Sun 11/8

7:29 pm-7:35 pm

2 stops25h 06m

$652

Des MoinesSyracuse

DSM Des Moines - SYR Syracuse Hancock Intl

DSMSYR

Des Moines

Tue 11/24

7:00 am-11:29 am

1 stop27h 29m

Syracuse Hancock Intl

Mon 11/30

12:24 pm-10:29 pm

2 stops11h 05m

$873

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Syracuse

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the typical price of a round-trip flight between Des Moines and Syracuse?

Prices are currently typical for flights on this route.

Typical prices usually range from $338 to $485.
The lowest price recently found on this route was $349.

What is the cheapest month to fly to Syracuse?

The month of February is, on average, the cheapest month to fly to Syracuse from Des Moines, with most prices found around $358. If you aren’t able to travel to Syracuse during the month of February, then flying in December is also cheap. Prices for this month can be found on momondo for an average of $387.

Can stopping save me money on Des Moines to Syracuse flights?

You could potentially save up to 38% on your flight if you consider stops on a Des Moines to Syracuse flight.

When to book flights from Des Moines to Syracuse

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Syracuse according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Syracuse (DSM to SYR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Syracuse

Best Price Found	$349
Fastest flight time	4h 02m
Direct flights	None

The best flight deal from Des Moines to Syracuse found on momondo in the last 72 hours is $349

The fastest flight from Des Moines to Syracuse takes 4h 02m

There are no direct flights from Des Moines to Syracuse. There are no popular flight routes from Des Moines to Syracuse.

Search flight deals

Frequently asked questions about flying from Des Moines to Syracuse

How far is Des Moines to Syracuse Hancock Intl by plane?
The straight-line distance from Des Moines to Syracuse Hancock Intl is 896.5 mi. 4h 02m is a normal flight duration for this route.
When did momondo last update prices for flights from Des Moines Airport to Syracuse Hancock Intl Airport?
Prices for flights from Des Moines Airport to Syracuse Hancock Intl Airport refresh daily.
How many operators does momondo search for flights from Des Moines Airport to Syracuse Hancock Intl Airport?
The number of operators available for flights from Des Moines Airport to Syracuse Hancock Intl Airport is 3 as of October 2026.
How old do you have to be to fly from Des Moines Airport to Syracuse Hancock Intl Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Syracuse Hancock Intl Airport.
What documentation or ID do you need to fly to Syracuse Hancock Intl Airport?
The travel and health documents you'll need for your trip to Syracuse Hancock Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Syracuse Hancock Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Des Moines to Syracuse?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Des Moines to Syracuse is American Airlines (46% of total bookings). The next most popular airlines are Delta (36%) and United Airlines (18%).

Best airlines flying from Des Moines to Syracuse

Compare and see reviews for airlines that fly from Des Moines to Syracuse with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $275	Free Cancellation	Rating 7.0 12,186 reviews	Search American Airlines flights
United Airlines	PriceFrom $326	Free Cancellation	Rating 7.3 10,404 reviews	Search United Airlines flights
Delta	PriceFrom $328	Free Cancellation	Rating 7.8 8,661 reviews	Search Delta flights

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Why should I use momondo to find a flight deal from Des Moines to Syracuse?

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Can I find flights from Des Moines to Syracuse with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Syracuse from Des Moines with this policy.

How can momondo help me find flights from Des Moines to Syracuse?

momondo provides multiple filters to help you find the best flight to Syracuse from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Syracuse right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Syracuse flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Cheap flights from Des Moines to Syracuse from $349

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Syracuse departing on 11/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Delta flights from Des Moines to Syracuse

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How to get the cheapest flight ticket from Des Moines to Syracuse

What is the typical price of a round-trip flight between Des Moines and Syracuse?

What is the cheapest month to fly to Syracuse?

Can stopping save me money on Des Moines to Syracuse flights?

What airlines fly to Syracuse?

When to book flights from Des Moines to Syracuse

Cheap Des Moines to Syracuse (DSM to SYR) flight deals and tips

Best Price Found

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Frequently asked questions about flying from Des Moines to Syracuse

Best airlines flying from Des Moines to Syracuse

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An easier way to manage your Syracuse trip

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