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Cheap flights from Des Moines to Syracuse from $229

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Syracuse departing on 3/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Syracuse

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:47 pm - 11:09 pm
DSM
-
SYR
4h 22m
1 stop
Delta Logo
12:43 pm - 7:27 pm
SYR
-
DSM
7h 44m
1 stop
$271Delta
Tue, Mar 24 - Tue, Mar 31
United Airlines Logo
11:22 am - 11:33 pm
DSM
-
SYR
11h 11m
2 stops
United Airlines Logo
6:15 am - 10:21 am
SYR
-
DSM
5h 06m
1 stop
$276United Airlines
Wed, Jun 10 - Wed, Jun 17
Delta Logo
5:25 pm - 10:56 pm
DSM
-
SYR
4h 31m
1 stop
Delta Logo
3:11 pm - 10:26 pm
SYR
-
DSM
8h 15m
1 stop
$303Delta
Wed, Jun 10 - Wed, Jun 17
Delta Logo
5:45 am - 2:11 pm
DSM
-
SYR
7h 26m
1 stop
Delta Logo
6:00 am - 9:19 am
SYR
-
DSM
4h 19m
1 stop
$337Delta
Wed, Jun 10 - Wed, Jun 17
United Airlines Logo
1:32 pm - 11:21 pm
DSM
-
SYR
8h 49m
1 stop
United Airlines Logo
6:15 am - 10:37 am
SYR
-
DSM
5h 22m
1 stop
$341United Airlines
Tue, Apr 28 - Sat, May 2
United Airlines Logo
1:32 pm - 11:21 pm
DSM
-
SYR
8h 49m
1 stop
United Airlines Logo
2:49 pm - 10:54 pm
SYR
-
DSM
9h 05m
2 stops
$346United Airlines
Tue, Apr 28 - Sat, May 2
United Airlines Logo
6:20 am - 2:08 pm
DSM
-
SYR
6h 48m
2 stops
United Airlines Logo
2:49 pm - 11:44 pm
SYR
-
DSM
9h 55m
2 stops
$351United Airlines
Tue, Apr 28 - Sat, May 2
American Airlines Logo
7:44 pm - 11:11 am
DSM
-
SYR
14h 27m
1 stop
American Airlines Logo
4:54 pm - 10:10 pm
SYR
-
DSM
6h 16m
1 stop
$358American Airlines
Mon, Mar 23 - Mon, Mar 30
United Airlines Logo
6:20 am - 2:08 pm
DSM
-
SYR
6h 48m
2 stops
United Airlines Logo
2:57 pm - 10:54 pm
SYR
-
DSM
8h 57m
2 stops
$370United Airlines
Tue, Apr 28 - Sat, May 2
Delta Logo
5:35 pm - 11:32 pm
DSM
-
SYR
4h 57m
1 stop
Delta Logo
6:00 am - 9:19 am
SYR
-
DSM
4h 19m
1 stop
$379Delta
Sat, Jul 25 - Sat, Aug 1

Delta flights from Des Moines to Syracuse

Our best Delta deals on Des Moines to Syracuse flight tickets
Delta
Mar 24
DSM5:47 pmDes Moines
4h 22m
1 stop
SYR11:09 pmSyracuse Hancock Intl
Mar 31
SYR12:43 pmSyracuse Hancock Intl
7h 44m
1 stop
DSM7:27 pmDes Moines
$271
Delta
Jun 10
DSM5:25 pmDes Moines
4h 31m
1 stop
SYR10:56 pmSyracuse Hancock Intl
Jun 17
SYR3:11 pmSyracuse Hancock Intl
8h 15m
1 stop
DSM10:26 pmDes Moines
$303
Delta
Jun 10
DSM5:45 amDes Moines
7h 26m
1 stop
SYR2:11 pmSyracuse Hancock Intl
Jun 17
SYR6:00 amSyracuse Hancock Intl
4h 19m
1 stop
DSM9:19 amDes Moines
$337

American Airlines flights from Des Moines to Syracuse

Our best American Airlines deals on Des Moines to Syracuse flight tickets
American Airlines
Mar 23
DSM7:44 pmDes Moines
14h 27m
1 stop
SYR11:11 amSyracuse Hancock Intl
Mar 30
SYR4:54 pmSyracuse Hancock Intl
6h 16m
1 stop
DSM10:10 pmDes Moines
$358
American Airlines
Mar 23
DSM7:44 pmDes Moines
14h 27m
1 stop
SYR11:11 amSyracuse Hancock Intl
Mar 30
SYR3:25 pmSyracuse Hancock Intl
8h 52m
2 stops
DSM11:17 pmDes Moines
$479
American Airlines
Mar 23
DSM5:00 amDes Moines
9h 35m
2 stops
SYR3:35 pmSyracuse Hancock Intl
Mar 30
SYR3:25 pmSyracuse Hancock Intl
9h 23m
2 stops
DSM11:48 pmDes Moines
$591

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from Des Moines to Syracuse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 3/24

5:47 pm-11:09 pm

1 stop4h 22m

Syracuse Hancock Intl

Tue 3/31

12:43 pm-7:27 pm

1 stop7h 44m

$271

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 6/10

11:22 am-11:33 pm

2 stops11h 11m

Syracuse Hancock Intl

Wed 6/17

6:15 am-10:21 am

1 stop5h 06m

$276

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 6/10

5:25 pm-10:56 pm

1 stop4h 31m

Syracuse Hancock Intl

Wed 6/17

3:11 pm-10:26 pm

1 stop8h 15m

$303

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 6/10

5:45 am-2:11 pm

1 stop7h 26m

Syracuse Hancock Intl

Wed 6/17

6:00 am-9:19 am

1 stop4h 19m

$337

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 4/28

1:32 pm-11:21 pm

1 stop8h 49m

Syracuse Hancock Intl

Sat 5/2

6:15 am-10:37 am

1 stop5h 22m

$341

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 4/28

1:32 pm-11:21 pm

1 stop8h 49m

Syracuse Hancock Intl

Sat 5/2

2:49 pm-10:54 pm

2 stops9h 05m

$346

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 4/28

6:20 am-2:08 pm

2 stops6h 48m

Syracuse Hancock Intl

Sat 5/2

2:49 pm-11:44 pm

2 stops9h 55m

$351

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Mon 3/23

7:44 pm-11:11 am

1 stop14h 27m

Syracuse Hancock Intl

Mon 3/30

4:54 pm-10:10 pm

1 stop6h 16m

$358

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 4/28

6:20 am-2:08 pm

2 stops6h 48m

Syracuse Hancock Intl

Sat 5/2

2:57 pm-10:54 pm

2 stops8h 57m

$370

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sat 7/25

5:35 pm-11:32 pm

1 stop4h 57m

Syracuse Hancock Intl

Sat 8/1

6:00 am-9:19 am

1 stop4h 19m

$379

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Syracuse

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Syracuse?

The month of September is, on average, the cheapest month to fly to Syracuse from Des Moines, with most prices found around $258. If you aren’t able to travel to Syracuse during the month of September, then flying in October is also cheap. Prices for this month can be found on momondo for an average of $273.

How have Des Moines to Syracuse flight prices changed over time?

When to book flights from Des Moines to Syracuse

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Syracuse according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Syracuse (DSM to SYR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Syracuse

Fastest flight time

4h 31m

Direct flights

None
The fastest flight from Des Moines to Syracuse takes 4h 31m
There are no direct flights from Des Moines to Syracuse. There are no popular flight routes from Des Moines to Syracuse.
Search flight deals

  • How far is Des Moines to Syracuse Hancock Intl by plane?

    The straight-line distance from Des Moines to Syracuse Hancock Intl is 896.5 mi. 4h 31m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Syracuse Hancock Intl Airport?

    Prices for flights from Des Moines Airport to Syracuse Hancock Intl Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Syracuse Hancock Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Syracuse Hancock Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Syracuse Hancock Intl Airport.

  • What documentation or ID do you need to fly to Syracuse Hancock Intl Airport?

    The travel and health documents you'll need for your trip to Syracuse Hancock Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Syracuse Hancock Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Syracuse?

Best airlines flying from Des Moines to Syracuse

Compare and see reviews for airlines that fly from Des Moines to Syracuse with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $236Free CancellationRating
7.9
8,174 reviews
Search Delta flights
American AirlinesPriceFrom $258Free CancellationRating
7.2
11,258 reviews
Search American Airlines flights

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
Skaneateles
Liverpool
Oswego
Auburn
East Syracuse
Waterloo
Seneca Falls
Cicero
Bridgeport

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Syracuse?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Syracuse. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Syracuse with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Syracuse from Des Moines with this policy.

How can momondo help me find flights from Des Moines to Syracuse?

momondo provides multiple filters to help you find the best flight to Syracuse from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Syracuse right now. Can momondo alert me if prices change?

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