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Cheap flights from Des Moines to Syracuse from $309

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Syracuse departing on 11/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Delta Logo
4:59 pm - 11:42 pmDSM-SYR
5h 43m1 stop
Delta Logo
6:00 am - 1:32 pmSYR-DSM
8h 32m1 stop
$309Delta
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Fri, Nov 21 - Tue, Nov 25
United Airlines Logo
3:14 pm - 11:51 pmDSM-SYR
7h 37m2 stops
United Airlines Logo
5:30 am - 2:33 pmSYR-DSM
10h 03m2 stops
$315United Airlines
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Wed, Dec 31 - Sat, Jan 3
United Airlines Logo
3:14 pm - 9:09 pmDSM-SYR
4h 55m1 stop
United Airlines Logo
6:15 am - 10:50 amSYR-DSM
5h 35m1 stop
$318United Airlines
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Wed, Dec 31 - Sat, Jan 3
United Airlines Logo
3:15 pm - 9:02 pmDSM-SYR
4h 47m1 stop
United Airlines Logo
9:46 pm - 1:42 amSYR-DSM
4h 56m1 stop
$329United Airlines
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Wed, Nov 26 - Sun, Nov 30
Delta Logo
5:35 am - 1:18 pmDSM-SYR
6h 43m1 stop
Delta Logo
5:32 pm - 8:47 pmSYR-DSM
4h 15m1 stop
$346Delta
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Sat, Nov 15 - Tue, Nov 18
American Airlines Logo
4:03 pm - 12:19 amDSM-SYR
7h 16m1 stop
American Airlines Logo
2:41 pm - 10:02 pmSYR-DSM
8h 21m2 stops
$351American Airlines
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Sat, Nov 15 - Tue, Nov 18
United Airlines Logo
3:14 pm - 9:09 pmDSM-SYR
4h 55m1 stop
United Airlines Logo
5:17 pm - 9:40 pmSYR-DSM
5h 23m1 stop
$359United Airlines
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Wed, Dec 31 - Fri, Jan 2
American Airlines Logo
3:27 pm - 11:38 pmDSM-SYR
7h 11m1 stop
American Airlines Logo
7:26 pm - 11:30 pmSYR-DSM
5h 04m1 stop
$372American Airlines
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Tue, Dec 30 - Thu, Jan 1
Multiple Airlines Logo
6:40 am - 2:07 pmDSM-SYR
30h 27m2 stops
Multiple Airlines Logo
10:18 am - 8:54 amSYR-DSM
23h 36m1 stop
$458Multiple Airlines
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Fri, Nov 21 - Tue, Nov 25
Multiple Airlines Logo
3:11 pm - 11:07 amDSM-SYR
18h 56m1 stop
Multiple Airlines Logo
3:02 pm - 7:44 pmSYR-DSM
29h 42m2 stops
$506Multiple Airlines
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Tue, Dec 30 - Fri, Jan 2

United Airlines flights from Des Moines to Syracuse

Our best United Airlines deals on Des Moines to Syracuse flight tickets
United Airlines
Dec 31
DSM3:14 pmDes Moines
7h 37m
2 stops
SYR11:51 pmSyracuse Hancock Intl
Jan 3
SYR5:30 amSyracuse Hancock Intl
10h 03m
2 stops
DSM2:33 pmDes Moines
$315
Find similar
United Airlines
Dec 31
DSM3:14 pmDes Moines
4h 55m
1 stop
SYR9:09 pmSyracuse Hancock Intl
Jan 3
SYR6:15 amSyracuse Hancock Intl
5h 35m
1 stop
DSM10:50 amDes Moines
$318
Find similar
United Airlines
Nov 26
DSM3:15 pmDes Moines
4h 47m
1 stop
SYR9:02 pmSyracuse Hancock Intl
Nov 30
SYR9:46 pmSyracuse Hancock Intl
4h 56m
1 stop
DSM1:42 amDes Moines
$329
Find similar

American Airlines flights from Des Moines to Syracuse

Our best American Airlines deals on Des Moines to Syracuse flight tickets
American Airlines
Nov 15
DSM4:03 pmDes Moines
7h 16m
1 stop
SYR12:19 amSyracuse Hancock Intl
Nov 18
SYR2:41 pmSyracuse Hancock Intl
8h 21m
2 stops
DSM10:02 pmDes Moines
$351
Find similar
American Airlines
Dec 30
DSM3:27 pmDes Moines
7h 11m
1 stop
SYR11:38 pmSyracuse Hancock Intl
Jan 1
SYR7:26 pmSyracuse Hancock Intl
5h 04m
1 stop
DSM11:30 pmDes Moines
$372
Find similar
American Airlines
Dec 30
DSM8:45 amDes Moines
13h 53m
1 stop
SYR11:38 pmSyracuse Hancock Intl
Jan 2
SYR7:26 pmSyracuse Hancock Intl
18h 28m
1 stop
DSM12:54 pmDes Moines
$387
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momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Des Moines to Syracuse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 11/21

4:59 pm-11:42 pm

1 stop5h 43m

Syracuse Hancock Intl

Tue 11/25

6:00 am-1:32 pm

1 stop8h 32m

$309

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 12/31

3:14 pm-11:51 pm

2 stops7h 37m

Syracuse Hancock Intl

Sat 1/3

5:30 am-2:33 pm

2 stops10h 03m

$315

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 12/31

3:14 pm-9:09 pm

1 stop4h 55m

Syracuse Hancock Intl

Sat 1/3

6:15 am-10:50 am

1 stop5h 35m

$318

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 11/26

3:15 pm-9:02 pm

1 stop4h 47m

Syracuse Hancock Intl

Sun 11/30

9:46 pm-1:42 am

1 stop4h 56m

$329

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sat 11/15

5:35 am-1:18 pm

1 stop6h 43m

Syracuse Hancock Intl

Tue 11/18

5:32 pm-8:47 pm

1 stop4h 15m

$346

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sat 11/15

4:03 pm-12:19 am

1 stop7h 16m

Syracuse Hancock Intl

Tue 11/18

2:41 pm-10:02 pm

2 stops8h 21m

$351

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 12/31

3:14 pm-9:09 pm

1 stop4h 55m

Syracuse Hancock Intl

Fri 1/2

5:17 pm-9:40 pm

1 stop5h 23m

$359

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 12/30

3:27 pm-11:38 pm

1 stop7h 11m

Syracuse Hancock Intl

Thu 1/1

7:26 pm-11:30 pm

1 stop5h 04m

$372

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 11/21

6:40 am-2:07 pm

2 stops30h 27m

Syracuse Hancock Intl

Tue 11/25

10:18 am-8:54 am

1 stop23h 36m

$458

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 12/30

3:11 pm-11:07 am

1 stop18h 56m

Syracuse Hancock Intl

Fri 1/2

3:02 pm-7:44 pm

2 stops29h 42m

$506

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Syracuse from

How to get the cheapest flight ticket from Des Moines to Syracuse

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Syracuse?

The month of September is, on average, the cheapest month to fly to Syracuse from Des Moines, with most prices found around $258. If you aren’t able to travel to Syracuse during the month of September, then flying in April is also cheap. Prices for this month can be found on momondo for an average of $272.

What is the cheapest day to depart on your flight to Syracuse?

The cheapest day to depart from Des Moines to Syracuse is on a Wednesday. Travelers who choose to depart for Syracuse on a Wednesday will often find tickets for as low as $257. The most expensive day to fly to Syracuse is Sunday, with ticket prices averaging around $567.

What is the cheapest time of day to depart on your flight to Syracuse?

Our most recent data shows that the best time of day to fly to Syracuse is in the morning. Flights from Des Moines to Syracuse during this time can be as low as $347. Flights to Syracuse are more costly in the afternoon, with an average ticket price of $458. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

How have Des Moines to Syracuse flight prices changed over time?

When to book flights from Des Moines to Syracuse

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Syracuse according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Syracuse (DSM to SYR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Syracuse

Direct flights

None
There are no direct flights from Des Moines to Syracuse. There are no popular flight routes from Des Moines to Syracuse.
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  • How far is Des Moines to Syracuse Hancock Intl by plane?

    The straight-line distance from Des Moines to Syracuse Hancock Intl is 896.5 mi. 4h 18m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Syracuse Hancock Intl Airport?

    Prices for flights from Des Moines Airport to Syracuse Hancock Intl Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Syracuse Hancock Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Syracuse Hancock Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Syracuse Hancock Intl Airport.

  • What documentation or ID do you need to fly to Syracuse Hancock Intl Airport?

    The travel and health documents you'll need for your trip to Syracuse Hancock Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Syracuse Hancock Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Syracuse?

Best airlines flying from Des Moines to Syracuse

Compare and see reviews for airlines that fly from Des Moines to Syracuse with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $236Free CancellationRating
7.9
8,004 reviews
Search Delta flights
American AirlinesPriceFrom $250Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
Skaneateles
Liverpool
Oswego
Auburn
East Syracuse
Seneca Falls
Waterloo
Cicero
Bridgeport

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Syracuse?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Syracuse. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Syracuse with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Syracuse from Des Moines with this policy.

How can momondo help me find flights from Des Moines to Syracuse?

momondo provides multiple filters to help you find the best flight to Syracuse from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

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