What airlines fly to Syracuse?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Syracuse from Des Moines according to our data. American Airlines is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Syracuse. Keep in mind that there are 3 different airlines that fly to Syracuse on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to Syracuse Hancock Intl Airport?

Prices for flights from Des Moines Airport to Syracuse Hancock Intl Airport refresh daily.

How many operators does momondo search for flights from Des Moines Airport to Syracuse Hancock Intl Airport?

The number of operators available for flights from Des Moines Airport to Syracuse Hancock Intl Airport is 2 as of December 2025.

How old do you have to be to fly from Des Moines Airport to Syracuse Hancock Intl Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Syracuse Hancock Intl Airport.

What documentation or ID do you need to fly to Syracuse Hancock Intl Airport?

The travel and health documents you'll need for your trip to Syracuse Hancock Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Syracuse Hancock Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$128 Cheap Flights from Des Moines to Syracuse in 2025/26

1 adult

0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Find the cheapest flights from Des Moines to Syracuse

Round-trip

One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:24 am - 12:01 pm

DSM

SYR

4h 37m1 stop

5:50 am - 9:41 am

SYR

DSM

4h 51m1 stop

$271Delta

Wed, Feb 4 - Wed, Feb 11

4:25 pm - 11:27 pm

DSM

SYR

6h 02m1 stop

2:15 pm - 11:08 pm

SYR

DSM

9h 53m2 stops

$276American Airlines

Tue, Feb 3 - Tue, Feb 10

6:07 am - 2:38 pm

DSM

SYR

7h 31m2 stops

2:15 pm - 10:11 pm

SYR

DSM

8h 56m2 stops

$281American Airlines

Tue, Feb 3 - Tue, Feb 10

8:00 am - 4:15 pm

DSM

SYR

7h 15m1 stop

4:57 pm - 9:50 pm

SYR

DSM

5h 53m1 stop

$294United Airlines

Fri, Jan 9 - Mon, Jan 12

8:00 am - 4:15 pm

DSM

SYR

7h 15m1 stop

5:48 am - 2:33 pm

SYR

DSM

9h 45m2 stops

$299United Airlines

Fri, Jan 9 - Mon, Jan 12

8:00 am - 4:28 pm

DSM

SYR

7h 28m1 stop

8:00 am - 2:33 pm

SYR

DSM

7h 33m1 stop

$307United Airlines

Thu, Jan 1 - Tue, Jan 6

5:01 pm - 11:54 pm

DSM

SYR

5h 53m1 stop

7:00 am - 11:12 am

SYR

DSM

5h 12m1 stop

$309American Airlines

Tue, Jan 6 - Sat, Jan 10

8:00 am - 4:28 pm

DSM

SYR

7h 28m1 stop

10:19 am - 9:50 pm

SYR

DSM

12h 31m2 stops

$312United Airlines

Thu, Jan 1 - Tue, Jan 6

5:00 am - 1:18 pm

DSM

SYR

7h 18m2 stops

8:21 pm - 11:22 pm

SYR

DSM

4h 01m1 stop

$314American Airlines

Sat, May 23 - Tue, May 26

7:30 am - 6:56 pm

DSM

SYR

10h 26m1 stop

6:51 pm - 10:19 am

SYR

DSM

16h 28m2 stops

$317Multiple Airlines

Fri, Jan 9 - Sun, Jan 11

American Airlines flights from Des Moines to Syracuse

Our best American Airlines deals on Des Moines to Syracuse flight tickets

American Airlines

Feb 3

DSM4:25 pmDes Moines

6h 02m

1 stop

SYR11:27 pmSyracuse Hancock Intl

Feb 10

SYR2:15 pmSyracuse Hancock Intl

9h 53m

2 stops

DSM11:08 pmDes Moines

$276

Find similar

American Airlines

Feb 3

DSM6:07 amDes Moines

7h 31m

2 stops

SYR2:38 pmSyracuse Hancock Intl

Feb 10

SYR2:15 pmSyracuse Hancock Intl

8h 56m

2 stops

DSM10:11 pmDes Moines

$281

Find similar

American Airlines

Jan 6

DSM5:01 pmDes Moines

5h 53m

1 stop

SYR11:54 pmSyracuse Hancock Intl

Jan 10

SYR7:00 amSyracuse Hancock Intl

5h 12m

1 stop

DSM11:12 amDes Moines

$309

Find similar

United Airlines flights from Des Moines to Syracuse

Our best United Airlines deals on Des Moines to Syracuse flight tickets

United Airlines

Jan 9

DSM8:00 amDes Moines

7h 15m

1 stop

SYR4:15 pmSyracuse Hancock Intl

Jan 12

SYR4:57 pmSyracuse Hancock Intl

5h 53m

1 stop

DSM9:50 pmDes Moines

$294

Find similar

United Airlines

Jan 9

DSM8:00 amDes Moines

7h 15m

1 stop

SYR4:15 pmSyracuse Hancock Intl

Jan 12

SYR5:48 amSyracuse Hancock Intl

9h 45m

2 stops

DSM2:33 pmDes Moines

$299

Find similar

United Airlines

Jan 1

DSM8:00 amDes Moines

7h 28m

1 stop

SYR4:28 pmSyracuse Hancock Intl

Jan 6

SYR8:00 amSyracuse Hancock Intl

7h 33m

1 stop

DSM2:33 pmDes Moines

$307

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 2/4

6:24 am-12:01 pm

1 stop4h 37m

Syracuse Hancock Intl

Wed 2/11

5:50 am-9:41 am

1 stop4h 51m

$271

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 2/3

4:25 pm-11:27 pm

1 stop6h 02m

Syracuse Hancock Intl

Tue 2/10

2:15 pm-11:08 pm

2 stops9h 53m

$276

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 2/3

6:07 am-2:38 pm

2 stops7h 31m

Syracuse Hancock Intl

Tue 2/10

2:15 pm-10:11 pm

2 stops8h 56m

$281

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 1/9

8:00 am-4:15 pm

1 stop7h 15m

Syracuse Hancock Intl

Mon 1/12

4:57 pm-9:50 pm

1 stop5h 53m

$294

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 1/9

8:00 am-4:15 pm

1 stop7h 15m

Syracuse Hancock Intl

Mon 1/12

5:48 am-2:33 pm

2 stops9h 45m

$299

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Thu 1/1

8:00 am-4:28 pm

1 stop7h 28m

Syracuse Hancock Intl

Tue 1/6

8:00 am-2:33 pm

1 stop7h 33m

$307

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 1/6

5:01 pm-11:54 pm

1 stop5h 53m

Syracuse Hancock Intl

Sat 1/10

7:00 am-11:12 am

1 stop5h 12m

$309

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Thu 1/1

8:00 am-4:28 pm

1 stop7h 28m

Syracuse Hancock Intl

Tue 1/6

10:19 am-9:50 pm

2 stops12h 31m

$312

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sat 5/23

5:00 am-1:18 pm

2 stops7h 18m

Syracuse Hancock Intl

Tue 5/26

8:21 pm-11:22 pm

1 stop4h 01m

$314

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 1/9

7:30 am-6:56 pm

1 stop10h 26m

Syracuse Hancock Intl

Sun 1/11

6:51 pm-10:19 am

2 stops16h 28m

$317

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Syracuse

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Syracuse?

The month of September is, on average, the cheapest month to fly to Syracuse from Des Moines, with most prices found around $258. If you aren’t able to travel to Syracuse during the month of September, then flying in April is also cheap. Prices for this month can be found on momondo for an average of $272.

What is the cheapest day to depart on your flight to Syracuse?

The cheapest day to depart from Des Moines to Syracuse is on a Wednesday. Travelers who choose to depart for Syracuse on a Wednesday will often find tickets for as low as $257. The most expensive day to fly to Syracuse is Sunday, with ticket prices averaging around $567.

What is the cheapest time of day to depart on your flight to Syracuse?

Our most recent data shows that the best time of day to fly to Syracuse is in the morning. Flights from Des Moines to Syracuse during this time can be as low as $347. Flights to Syracuse are more costly in the afternoon, with an average ticket price of $458. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

How have Des Moines to Syracuse flight prices changed over time?

When to book flights from Des Moines to Syracuse

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Syracuse according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Syracuse (DSM to SYR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Syracuse

Fastest flight time	4h 53m
Direct flights	None

The fastest flight from Des Moines to Syracuse takes 4h 53m

There are no direct flights from Des Moines to Syracuse. There are no popular flight routes from Des Moines to Syracuse.

Search flight deals

How far is Des Moines to Syracuse Hancock Intl by plane?
The straight-line distance from Des Moines to Syracuse Hancock Intl is 896.5 mi. 4h 53m is a normal flight duration for this route.
When did momondo last update prices for flights from Des Moines Airport to Syracuse Hancock Intl Airport?
Prices for flights from Des Moines Airport to Syracuse Hancock Intl Airport refresh daily.
How many operators does momondo search for flights from Des Moines Airport to Syracuse Hancock Intl Airport?
The number of operators available for flights from Des Moines Airport to Syracuse Hancock Intl Airport is 2 as of December 2025.
How old do you have to be to fly from Des Moines Airport to Syracuse Hancock Intl Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Syracuse Hancock Intl Airport.
What documentation or ID do you need to fly to Syracuse Hancock Intl Airport?
The travel and health documents you'll need for your trip to Syracuse Hancock Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Syracuse Hancock Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Des Moines to Syracuse?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Des Moines to Syracuse is American Airlines (66% of total bookings). The next most popular airline is Delta (34%).

Best airlines flying from Des Moines to Syracuse

Compare and see reviews for airlines that fly from Des Moines to Syracuse with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $236	Free Cancellation	Rating 7.9 8,014 reviews		Search Delta flights
American Airlines	PriceFrom $258	Free Cancellation	Rating 7.2 11,054 reviews		Search American Airlines flights

Skaneateles

Liverpool

Oswego

Auburn

East Syracuse

Seneca Falls

Waterloo

Cicero

Bridgeport

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Syracuse?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Syracuse. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Syracuse with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Syracuse from Des Moines with this policy.

How can momondo help me find flights from Des Moines to Syracuse?

momondo provides multiple filters to help you find the best flight to Syracuse from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Syracuse right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Syracuse flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.