What airlines fly to South Carolina?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to South Carolina from Des Moines according to our data. American Airlines is the first choice among our users, with 66% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Des Moines to South Carolina?

Allegiant Air, United Airlines, and Delta are the most popular carriers operating from Des Moines to South Carolina

How many flights depart from Des Moines to South Carolina on average per week?

7 flights are operational weekly from Des Moines to South Carolina as of May 2026. The most popular departure day for this route is Mon, with 29% of flights per week taking off on this day.

When did momondo last update prices for flights from Des Moines Airport to South Carolina?

Prices for flights from Des Moines Airport to South Carolina refresh daily.

How many operators does momondo search for flights from Des Moines Airport to South Carolina?

There are 4 operators available for flights from Des Moines Airport to South Carolina as of May 2026.

How old do you have to be to fly from Des Moines Airport to South Carolina?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$99 Cheap Flights from Des Moines to South Carolina in 2026

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Find the cheapest flights from Des Moines to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

2:16 pm - 6:18 pm

DSM

CLT

27h 02m

1 stop

7:14 pm - 1:31 pm

CLT

DSM

19h 17m

1 stop

$240Frontier

Mon, Jun 1 - Thu, Jun 4

2:16 pm - 6:18 pm

DSM

CLT

27h 02m

1 stop

7:14 pm - 1:31 pm

CLT

DSM

19h 17m

1 stop

$260Frontier

Wed, Jun 3 - Sun, Jun 14

4:48 pm - 11:39 pm

DSM

CAE

5h 51m

1 stop

8:30 pm - 12:07 am

CAE

DSM

4h 37m

1 stop

$285American Airlines

Sat, Jun 27 - Wed, Jul 1

7:11 am - 2:42 pm

DSM

CAE

6h 31m

1 stop

3:12 pm - 8:51 pm

CAE

DSM

6h 39m

1 stop

$297American Airlines

Wed, Jul 8 - Fri, Jul 17

11:23 am - 5:05 pm

DSM

CAE

4h 42m

1 stop

2:51 pm - 10:51 pm

CAE

DSM

9h 00m

2 stops

$324United Airlines

Fri, Jul 3 - Wed, Jul 8

6:39 pm - 11:59 pm

DSM

MYR

4h 20m

1 stop

4:17 pm - 10:31 pm

MYR

DSM

7h 14m

1 stop

$351Delta

Tue, Jun 9 - Tue, Jun 16

5:41 am - 12:14 pm

DSM

GSP

5h 33m

1 stop

11:38 am - 5:52 pm

GSP

DSM

7h 14m

1 stop

$355Delta

Wed, Jul 8 - Tue, Jul 21

3:01 pm - 10:15 pm

DSM

CHS

6h 14m

1 stop

6:00 am - 10:17 am

CHS

DSM

5h 17m

1 stop

$355United Airlines

Wed, Jul 8 - Wed, Jul 15

5:20 am - 6:15 pm

DSM

CHS

11h 55m

2 stops

6:10 am - 11:30 am

CHS

DSM

6h 20m

1 stop

$360Southwest

Wed, Jul 8 - Wed, Jul 15

5:10 am - 11:20 am

DSM

SAV

5h 10m

1 stop

6:35 pm - 10:45 pm

SAV

DSM

5h 10m

1 stop

$365Southwest

Sat, Jul 4 - Wed, Jul 8

Frontier flights from Des Moines to South Carolina

Our best Frontier deals on Des Moines to South Carolina flight tickets

Frontier

May 27

DSM2:16 pmDes Moines

27h 02m

1 stop

CLT6:18 pmCharlotte Douglas

Aug 20

CLT7:14 pmCharlotte Douglas

19h 17m

1 stop

DSM1:31 pmDes Moines

$225

Frontier

Jun 1

DSM2:16 pmDes Moines

27h 02m

1 stop

CLT6:18 pmCharlotte Douglas

Jun 4

CLT7:14 pmCharlotte Douglas

19h 17m

1 stop

DSM1:31 pmDes Moines

$240

Frontier

Jun 3

DSM2:16 pmDes Moines

27h 02m

1 stop

CLT6:18 pmCharlotte Douglas

Jun 14

CLT7:14 pmCharlotte Douglas

19h 17m

1 stop

DSM1:31 pmDes Moines

$260

American Airlines flights from Des Moines to South Carolina

Our best American Airlines deals on Des Moines to South Carolina flight tickets

American Airlines

Jun 27

DSM4:48 pmDes Moines

5h 51m

1 stop

CAE11:39 pmColumbia Metropolitan

Jul 1

CAE8:30 pmColumbia Metropolitan

4h 37m

1 stop

DSM12:07 amDes Moines

$285

American Airlines

Jul 8

DSM7:11 amDes Moines

6h 31m

1 stop

CAE2:42 pmColumbia Metropolitan

Jul 17

CAE3:12 pmColumbia Metropolitan

6h 39m

1 stop

DSM8:51 pmDes Moines

$297

American Airlines

Jun 12

DSM7:10 amDes Moines

6h 29m

1 stop

CAE2:39 pmColumbia Metropolitan

Jun 15

CAE7:22 pmColumbia Metropolitan

5h 36m

1 stop

DSM11:58 pmDes Moines

$307

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Mon 6/1

2:16 pm-6:18 pm

1 stop27h 02m

Charlotte Douglas

Thu 6/4

7:14 pm-1:31 pm

1 stop19h 17m

$240

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Wed 6/3

2:16 pm-6:18 pm

1 stop27h 02m

Charlotte Douglas

Sun 6/14

7:14 pm-1:31 pm

1 stop19h 17m

$260

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 6/27

4:48 pm-11:39 pm

1 stop5h 51m

Columbia Metropolitan

Wed 7/1

8:30 pm-12:07 am

1 stop4h 37m

$285

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Wed 7/8

7:11 am-2:42 pm

1 stop6h 31m

Columbia Metropolitan

Fri 7/17

3:12 pm-8:51 pm

1 stop6h 39m

$297

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Fri 7/3

11:23 am-5:05 pm

1 stop4h 42m

Columbia Metropolitan

Wed 7/8

2:51 pm-10:51 pm

2 stops9h 00m

$324

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 6/9

6:39 pm-11:59 pm

1 stop4h 20m

Myrtle Beach Intl

Tue 6/16

4:17 pm-10:31 pm

1 stop7h 14m

$351

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 7/8

5:41 am-12:14 pm

1 stop5h 33m

Greenville

Tue 7/21

11:38 am-5:52 pm

1 stop7h 14m

$355

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 7/8

3:01 pm-10:15 pm

1 stop6h 14m

Charleston

Wed 7/15

6:00 am-10:17 am

1 stop5h 17m

$355

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 7/8

5:20 am-6:15 pm

2 stops11h 55m

Charleston

Wed 7/15

6:10 am-11:30 am

1 stop6h 20m

$360

Quickest round-trip

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Sat 7/4

5:10 am-11:20 am

1 stop5h 10m

Savannah/Hilton Head

Wed 7/8

6:35 pm-10:45 pm

1 stop5h 10m

$365

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Des Moines is in November. Flight prices, which tend to average around $118, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of November, then book flights to South Carolina from Des Moines during September instead. Flights to South Carolina in September, while not as cheap as those in November, still average around $158.

Can stopping save me money on Des Moines to South Carolina flights?

You could potentially save up to 17% on your flight if you consider stops on a Des Moines to South Carolina flight.

Cheap Des Moines to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to South Carolina

Fastest flight time	2h 27m
Direct flights	Every day
Airports in South Carolina	57 airports

The fastest flight from Des Moines to South Carolina takes 2h 27m

Direct flights go from Des Moines to South Carolina every day.

There are 57 airports in South Carolina. From Des Moines there are direct flights to Charlotte Douglas (CLT).

Search flight deals

Frequently asked questions about flying from Des Moines to South Carolina

When did momondo last update prices for flights from Des Moines Airport to South Carolina?
Prices for flights from Des Moines Airport to South Carolina refresh daily.
How many operators does momondo search for flights from Des Moines Airport to South Carolina?
There are 4 operators available for flights from Des Moines Airport to South Carolina as of May 2026.
How old do you have to be to fly from Des Moines Airport to South Carolina?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to South Carolina

Compare and see reviews for airlines that fly from Des Moines to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $237	Free Cancellation	Rating 7.1 11,648 reviews	Search American Airlines flights
Delta	PriceFrom $237	Free Cancellation	Rating 7.9 8,447 reviews	Search Delta flights
United Airlines	PriceFrom $266	Free Cancellation	Rating 7.4 9,737 reviews	Search United Airlines flights
Southwest	PriceFrom $272	Free Cancellation	Rating 7.9 4,287 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to South Carolina?

Finding the right flight to South Carolina from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South Carolina quick and easy, saving you time and money.

Can I find flights from Des Moines to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to South Carolina?

momondo helps you find the best flight between Des Moines and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.