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Cheap flights from Des Moines to South Carolina from $97

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to South Carolina departing on 1/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:40 am - 7:33 amDSM-SAV
21h 53m1 stop
Multiple Airlines Logo
8:28 am - 2:55 pmSAV-DSM
7h 27m1 stop
$208Multiple Airlines
Find Deal
lun., nov. 10 - vie., nov. 14
Frontier Logo
7:36 pm - 11:17 amDSM-CLT
14h 41m1 stop
Frontier Logo
12:12 pm - 6:41 pmCLT-DSM
7h 29m1 stop
$222Frontier
Find Deal
jue., feb. 19 - jue., feb. 26
Delta Logo
11:04 am - 5:58 pmDSM-CAE
5h 54m1 stop
Delta Logo
6:50 pm - 10:28 pmCAE-DSM
4h 38m1 stop
$249Delta
Find Deal
sáb., abr. 4 - mié., abr. 8
United Airlines Logo
8:00 am - 1:47 pmDSM-CAE
4h 47m1 stop
United Airlines Logo
10:20 am - 8:48 pmCAE-DSM
11h 28m2 stops
$254United Airlines
Find Deal
jue., dic. 4 - mar., dic. 9
American Airlines Logo
3:39 pm - 10:52 pmDSM-CAE
6h 13m1 stop
American Airlines Logo
7:00 am - 12:24 pmCAE-DSM
6h 24m1 stop
$279American Airlines
Find Deal
vie., nov. 14 - lun., nov. 17
United Airlines Logo
5:45 am - 4:43 pmDSM-CAE
9h 58m2 stops
United Airlines Logo
5:24 pm - 9:32 pmCAE-DSM
5h 08m1 stop
$284United Airlines
Find Deal
jue., nov. 13 - sáb., nov. 15
American Airlines Logo
6:00 am - 1:39 pmDSM-CHS
6h 39m2 stops
American Airlines Logo
6:00 am - 12:46 pmCHS-DSM
7h 46m1 stop
$294American Airlines
Find Deal
dom., ene. 18 - sáb., ene. 24
Delta Logo
5:34 am - 11:03 amDSM-GSP
4h 29m1 stop
Delta Logo
11:30 am - 7:34 pmGSP-DSM
9h 04m1 stop
$297Delta
Find Deal
mar., ene. 20 - mar., ene. 27
Southwest Logo
8:35 am - 7:50 pmDSM-GSP
10h 15m2 stops
Southwest Logo
11:15 am - 7:20 pmGSP-DSM
9h 05m2 stops
$323Southwest
Find Deal
jue., ene. 22 - lun., ene. 26
Southwest Logo
6:10 am - 5:20 pmDSM-CLT
10h 10m2 stops
Southwest Logo
1:35 pm - 7:20 pmCLT-DSM
6h 45m1 stop
$358Southwest
Find Deal
mar., ene. 20 - mar., ene. 27

Frontier flights from Des Moines to South Carolina

Our best Frontier deals on Des Moines to South Carolina flight tickets
Frontier
Feb 19
DSM7:36 pmDes Moines
14h 41m
1 stop
CLT11:17 amCharlotte Douglas
Feb 26
CLT12:12 pmCharlotte Douglas
7h 29m
1 stop
DSM6:41 pmDes Moines
$222
Find similar
Frontier
Nov 7
DSM2:32 pmDes Moines
18h 40m
2 stops
CLT10:12 amCharlotte Douglas
Nov 9
CLT6:20 pmCharlotte Douglas
20h 27m
1 stop
DSM1:47 pmDes Moines
$416
Find similar

Southwest flights from Des Moines to South Carolina

Our best Southwest deals on Des Moines to South Carolina flight tickets
Southwest
Jan 22
DSM8:35 amDes Moines
10h 15m
2 stops
GSP7:50 pmGreenville
Jan 26
GSP11:15 amGreenville
9h 05m
2 stops
DSM7:20 pmDes Moines
$323
Find similar
Southwest
Jan 20
DSM6:10 amDes Moines
10h 10m
2 stops
CLT5:20 pmCharlotte Douglas
Jan 27
CLT1:35 pmCharlotte Douglas
6h 45m
1 stop
DSM7:20 pmDes Moines
$358
Find similar
Southwest
Jan 23
DSM6:10 amDes Moines
10h 25m
2 stops
CHS5:35 pmCharleston
Jan 26
CHS9:05 amCharleston
11h 15m
2 stops
DSM7:20 pmDes Moines
$360
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated octubre 30, 2025.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

lun. 11/10

8:40 am-7:33 am

1 stop21h 53m

Savannah/Hilton Head

vie. 11/14

8:28 am-2:55 pm

1 stop7h 27m

$208

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

jue. 2/19

7:36 pm-11:17 am

1 stop14h 41m

Charlotte Douglas

jue. 2/26

12:12 pm-6:41 pm

1 stop7h 29m

$222

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

sáb. 4/4

11:04 am-5:58 pm

1 stop5h 54m

Columbia Metropolitan

mié. 4/8

6:50 pm-10:28 pm

1 stop4h 38m

$249

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

jue. 12/4

8:00 am-1:47 pm

1 stop4h 47m

Columbia Metropolitan

mar. 12/9

10:20 am-8:48 pm

2 stops11h 28m

$254

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

vie. 11/14

3:39 pm-10:52 pm

1 stop6h 13m

Columbia Metropolitan

lun. 11/17

7:00 am-12:24 pm

1 stop6h 24m

$279

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

jue. 11/13

5:45 am-4:43 pm

2 stops9h 58m

Columbia Metropolitan

sáb. 11/15

5:24 pm-9:32 pm

1 stop5h 08m

$284

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

dom. 1/18

6:00 am-1:39 pm

2 stops6h 39m

Charleston

sáb. 1/24

6:00 am-12:46 pm

1 stop7h 46m

$294

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

mar. 1/20

5:34 am-11:03 am

1 stop4h 29m

Greenville

mar. 1/27

11:30 am-7:34 pm

1 stop9h 04m

$297

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

jue. 1/22

8:35 am-7:50 pm

2 stops10h 15m

Greenville

lun. 1/26

11:15 am-7:20 pm

2 stops9h 05m

$323

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

mar. 1/20

6:10 am-5:20 pm

2 stops10h 10m

Charlotte Douglas

mar. 1/27

1:35 pm-7:20 pm

1 stop6h 45m

$358

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Des Moines to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Des Moines is in September. Flight prices, which tend to average around $285, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Des Moines during May instead. Flights to South Carolina in May, while not as cheap as those in September, still average around $331.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $379. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $508.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Des Moines to South Carolina flights are usually those with departure times in the afternoon. Our users have found flights to South Carolina in the afternoon for as low as $386. Try not to purchase tickets in the morning because they tend to be around $405. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $395 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Des Moines for as low as $286 on momondo.

Can stopping save me money on Des Moines to South Carolina flights?

You could potentially save up to 28% on your flight if you consider stops on a Des Moines to South Carolina flight.

Cheap Des Moines to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to South Carolina

Fastest flight time

2h 18m

Direct flights

Mon, Wed, Thu, Fri, Sat and Sun

Airports in South Carolina

1 airport
The fastest flight from Des Moines to South Carolina takes 2h 18m
Direct flights go from Des Moines to South Carolina on Monday, Wednesday, Thursday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport near South Carolina: Charlotte Douglas (CLT)
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to South Carolina?

    Prices for flights from Des Moines Airport to South Carolina refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to South Carolina?

  • How old do you have to be to fly from Des Moines Airport to South Carolina?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to South Carolina

Compare and see reviews for airlines that fly from Des Moines to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $199Free CancellationRating
7.9
7,998 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,035 reviews
Search American Airlines flights
United AirlinesPriceFrom $266Free CancellationRating
7.4
8,998 reviews
Search United Airlines flights
SouthwestPriceFrom $272Free CancellationRating
8.0
4,243 reviews
Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to South Carolina?

Finding the right flight to South Carolina from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South Carolina quick and easy, saving you time and money.

Can I find flights from Des Moines to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to South Carolina?

momondo helps you find the best flight between Des Moines and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your South Carolina trip

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