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Cheap flights from Des Moines to South Carolina from $108

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to South Carolina departing on 11/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to South Carolina

Cheap round-trip flights

American Airlines Logo
6:40 pm - 8:02 amDSM-CLT
12h 22m1 stop
American Airlines Logo
11:50 am - 1:31 pmCLT-DSM
2h 41mnonstop
$229American Airlines
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Sat, Nov 8 - Sun, Nov 9
United Airlines Logo
1:05 pm - 9:33 pmDSM-SAV
7h 28m1 stop
United Airlines Logo
10:00 am - 2:19 pmSAV-DSM
5h 19m1 stop
$237United Airlines
Find Deal
Wed, Nov 5 - Tue, Nov 11
American Airlines Logo
2:19 pm - 11:19 pmDSM-SAV
8h 00m2 stops
American Airlines Logo
3:52 pm - 10:59 pmSAV-DSM
8h 07m1 stop
$242American Airlines
Find Deal
Wed, Nov 5 - Tue, Nov 11
American Airlines Logo
2:19 pm - 11:59 pmDSM-SAV
8h 40m2 stops
American Airlines Logo
3:05 pm - 10:08 pmSAV-DSM
8h 03m2 stops
$247American Airlines
Find Deal
Wed, Nov 5 - Tue, Nov 11
Delta Logo
2:13 pm - 7:31 pmDSM-SAV
4h 18m1 stop
Delta Logo
8:17 am - 1:28 pmSAV-DSM
6h 11m1 stop
$248Delta
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Wed, Oct 22 - Thu, Oct 30
Delta Logo
5:32 pm - 11:15 pmDSM-CLT
4h 43m1 stop
Delta Logo
6:00 am - 9:20 amCLT-DSM
4h 20m1 stop
$257Delta
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Fri, Oct 24 - Sun, Oct 26
Southwest Logo
6:25 am - 6:40 pmDSM-SAV
11h 15m2 stops
Southwest Logo
4:00 pm - 9:10 pmSAV-DSM
6h 10m2 stops
$258Southwest
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Thu, Jan 15 - Tue, Jan 20
United Airlines Logo
3:25 pm - 9:47 pmDSM-SAV
5h 22m1 stop
United Airlines Logo
7:10 am - 2:13 pmSAV-DSM
8h 03m1 stop
$259United Airlines
Find Deal
Mon, Oct 13 - Sat, Oct 18
Frontier Logo
2:34 pm - 10:12 amDSM-CLT
18h 38m2 stops
Frontier Logo
10:42 pm - 1:47 pmCLT-DSM
16h 05m2 stops
$305Frontier
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Fri, Nov 14 - Sun, Nov 16
Southwest Logo
4:45 pm - 9:30 pmDSM-CLT
3h 45m1 stop
Southwest Logo
2:00 pm - 9:50 pmCLT-DSM
8h 50m1 stop
$310Southwest
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Tue, Oct 14 - Tue, Oct 21

American Airlines flights from Des Moines to South Carolina

Our best American Airlines deals on Des Moines to South Carolina flight tickets
American Airlines
Nov 8
DSM6:40 pmDes Moines
12h 22m
1 stop
CLT8:02 amCharlotte Douglas
Nov 9
CLT11:50 amCharlotte Douglas
2h 41m
DSM1:31 pmDes Moines
$229
Find similar
American Airlines
Nov 5
DSM2:19 pmDes Moines
8h 00m
2 stops
SAV11:19 pmSavannah/Hilton Head
Nov 11
SAV3:52 pmSavannah/Hilton Head
8h 07m
1 stop
DSM10:59 pmDes Moines
$242
Find similar
American Airlines
Nov 5
DSM2:19 pmDes Moines
8h 40m
2 stops
SAV11:59 pmSavannah/Hilton Head
Nov 11
SAV3:05 pmSavannah/Hilton Head
8h 03m
2 stops
DSM10:08 pmDes Moines
$247
Find similar

Delta flights from Des Moines to South Carolina

Our best Delta deals on Des Moines to South Carolina flight tickets
Delta
Oct 22
DSM2:13 pmDes Moines
4h 18m
1 stop
SAV7:31 pmSavannah/Hilton Head
Oct 30
SAV8:17 amSavannah/Hilton Head
6h 11m
1 stop
DSM1:28 pmDes Moines
$248
Find similar
Delta
Oct 24
DSM5:32 pmDes Moines
4h 43m
1 stop
CLT11:15 pmCharlotte Douglas
Oct 26
CLT6:00 amCharlotte Douglas
4h 20m
1 stop
DSM9:20 amDes Moines
$257
Find similar
Delta
Oct 10
DSM6:39 pmDes Moines
4h 11m
1 stop
CLT11:50 pmCharlotte Douglas
Oct 12
CLT6:45 amCharlotte Douglas
4h 20m
1 stop
DSM10:05 amDes Moines
$277
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Sat 11/8

6:40 pm-8:02 am

1 stop12h 22m

Charlotte Douglas

Sun 11/9

11:50 am-1:31 pm

Nonstop2h 41m

$229

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Wed 11/5

1:05 pm-9:33 pm

1 stop7h 28m

Savannah/Hilton Head

Tue 11/11

10:00 am-2:19 pm

1 stop5h 19m

$237

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Wed 11/5

2:19 pm-11:19 pm

2 stops8h 00m

Savannah/Hilton Head

Tue 11/11

3:52 pm-10:59 pm

1 stop8h 07m

$242

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Wed 11/5

2:19 pm-11:59 pm

2 stops8h 40m

Savannah/Hilton Head

Tue 11/11

3:05 pm-10:08 pm

2 stops8h 03m

$247

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Wed 10/22

2:13 pm-7:31 pm

1 stop4h 18m

Savannah/Hilton Head

Thu 10/30

8:17 am-1:28 pm

1 stop6h 11m

$248

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Fri 10/24

5:32 pm-11:15 pm

1 stop4h 43m

Charlotte Douglas

Sun 10/26

6:00 am-9:20 am

1 stop4h 20m

$257

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Thu 1/15

6:25 am-6:40 pm

2 stops11h 15m

Savannah/Hilton Head

Tue 1/20

4:00 pm-9:10 pm

2 stops6h 10m

$258

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Mon 10/13

3:25 pm-9:47 pm

1 stop5h 22m

Savannah/Hilton Head

Sat 10/18

7:10 am-2:13 pm

1 stop8h 03m

$259

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Fri 11/14

2:34 pm-10:12 am

2 stops18h 38m

Charlotte Douglas

Sun 11/16

10:42 pm-1:47 pm

2 stops16h 05m

$305

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Tue 10/14

4:45 pm-9:30 pm

1 stop3h 45m

Charlotte Douglas

Tue 10/21

2:00 pm-9:50 pm

1 stop8h 50m

$310

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Des Moines to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Des Moines is in September. Flight prices, which tend to average around $296, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Des Moines during May instead. Flights to South Carolina in May, while not as cheap as those in September, still average around $331.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $379. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $508.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Des Moines to South Carolina flights are usually those with departure times in the afternoon. Our users have found flights to South Carolina in the afternoon for as low as $386. Try not to purchase tickets in the morning because they tend to be around $405. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $394 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Des Moines for as low as $335 on momondo.

Can stopping save me money on Des Moines to South Carolina flights?

You could potentially save up to 57% on your flight if you consider stops on a Des Moines to South Carolina flight.

Cheap Des Moines to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to South Carolina

Fastest flight time

2h 18m

Direct flights

Mon, Tue, Wed, Fri, Sat and Sun

Airports in South Carolina

1 airport
The fastest flight from Des Moines to South Carolina takes 2h 18m
Direct flights go from Des Moines to South Carolina on Monday, Tuesday, Wednesday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport near South Carolina: Charlotte Douglas (CLT)
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  • When did momondo last update prices for flights from Des Moines Airport to South Carolina?

    Prices for flights from Des Moines Airport to South Carolina refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to South Carolina?

  • How old do you have to be to fly from Des Moines Airport to South Carolina?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to South Carolina

Compare and see reviews for airlines that fly from Des Moines to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $237Free CancellationRating
7.9
7,957 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
SouthwestPriceFrom $272Free CancellationRating
8.0
4,242 reviews
Search Southwest flights
United AirlinesPriceFrom $286Free CancellationRating
7.4
8,924 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to South Carolina?

Finding the right flight to South Carolina from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South Carolina quick and easy, saving you time and money.

Can I find flights from Des Moines to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to South Carolina?

momondo helps you find the best flight between Des Moines and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your South Carolina trip

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