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Cheap flights from Des Moines to South Carolina from $113

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to South Carolina departing on 11/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to South Carolina

Cheap round-trip flights

Logo
4:29 pm - 8:05 amDSM-CLT
14h 36m2 stops
Logo
2:52 pm - 8:41 pmCLT-DSM
6h 49m1 stop
$220
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Fri, Aug 22 - Mon, Aug 25
Logo
2:22 pm - 9:22 amDSM-CLT
18h 00m2 stops
Logo
9:10 am - 2:40 pmCLT-DSM
6h 30m1 stop
$224
Find Deal
Mon, Sep 8 - Fri, Sep 12
American Airlines Logo
4:09 pm - 10:44 pmDSM-CHS
5h 35m1 stop
American Airlines Logo
7:28 pm - 11:06 pmCHS-DSM
4h 38m1 stop
$236American Airlines
Find Deal
Fri, Sep 12 - Fri, Sep 19
American Airlines Logo
3:46 pm - 9:31 pmDSM-SAV
4h 45m1 stop
American Airlines Logo
7:03 pm - 11:06 pmSAV-DSM
5h 03m1 stop
$236American Airlines
Find Deal
Sat, Sep 13 - Sat, Sep 20
Southwest Logo
4:45 pm - 9:30 pmDSM-CLT
3h 45m1 stop
Southwest Logo
6:25 pm - 11:35 pmCLT-DSM
6h 10m1 stop
$236Southwest
Find Deal
Tue, Oct 21 - Thu, Nov 6
Delta Logo
5:44 am - 11:48 amDSM-CHS
5h 04m1 stop
Delta Logo
3:07 pm - 9:03 pmCHS-DSM
6h 56m1 stop
$237Delta
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Sun, Oct 5 - Sat, Oct 11
Delta Logo
5:44 am - 1:28 pmDSM-GSP
6h 44m1 stop
Delta Logo
7:35 am - 10:40 amGSP-DSM
4h 05m1 stop
$237Delta
Find Deal
Sun, Sep 14 - Sun, Sep 21
Southwest Logo
8:35 am - 4:35 pmDSM-CLT
7h 00m1 stop
Southwest Logo
5:25 pm - 10:20 pmCLT-DSM
5h 55m1 stop
$242Southwest
Find Deal
Sat, Aug 30 - Wed, Sep 3
United Airlines Logo
8:00 am - 2:31 pmDSM-MYR
5h 31m1 stop
United Airlines Logo
3:45 pm - 11:41 pmMYR-DSM
8h 56m1 stop
$307United Airlines
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Wed, Aug 27 - Sat, Aug 30
United Airlines Logo
8:00 am - 2:27 pmDSM-SAV
5h 27m1 stop
United Airlines Logo
4:55 pm - 9:40 pmSAV-DSM
5h 45m1 stop
$307United Airlines
Find Deal
Wed, Dec 17 - Wed, Dec 24

American Airlines flights from Des Moines to South Carolina

Our best American Airlines deals on Des Moines to South Carolina flight tickets
American Airlines
Sep 12
DSM4:09 pmDes Moines
5h 35m
1 stop
CHS10:44 pmCharleston
Sep 19
CHS7:28 pmCharleston
4h 38m
1 stop
DSM11:06 pmDes Moines
$236
Find similar
American Airlines
Sep 13
DSM3:46 pmDes Moines
4h 45m
1 stop
SAV9:31 pmSavannah/Hilton Head
Sep 20
SAV5:29 pmSavannah/Hilton Head
5h 29m
1 stop
DSM9:58 pmDes Moines
$237
Find similar
American Airlines
Sep 13
DSM5:10 amDes Moines
8h 43m
2 stops
SAV2:53 pmSavannah/Hilton Head
Sep 20
SAV7:05 amSavannah/Hilton Head
7h 00m
1 stop
DSM1:05 pmDes Moines
$241
Find similar

United Airlines flights from Des Moines to South Carolina

Our best United Airlines deals on Des Moines to South Carolina flight tickets
United Airlines
Aug 27
DSM8:00 amDes Moines
5h 31m
1 stop
MYR2:31 pmMyrtle Beach Intl
Aug 30
MYR3:45 pmMyrtle Beach Intl
8h 56m
1 stop
DSM11:41 pmDes Moines
$307
Find similar
United Airlines
Sep 13
DSM2:58 pmDes Moines
6h 01m
1 stop
SAV9:59 pmSavannah/Hilton Head
Sep 20
SAV6:22 amSavannah/Hilton Head
11h 52m
2 stops
DSM5:14 pmDes Moines
$312
Find similar
United Airlines
Sep 13
DSM11:35 amDes Moines
11h 14m
2 stops
SAV11:49 pmSavannah/Hilton Head
Sep 20
SAV6:22 amSavannah/Hilton Head
11h 52m
2 stops
DSM5:14 pmDes Moines
$317
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Fri 8/22

4:29 pm-8:05 am

2 stops14h 36m

Charlotte Douglas

Mon 8/25

2:52 pm-8:41 pm

1 stop6h 49m

$220

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Mon 9/8

2:22 pm-9:22 am

2 stops18h 00m

Charlotte Douglas

Fri 9/12

9:10 am-2:40 pm

1 stop6h 30m

$224

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 9/12

4:09 pm-10:44 pm

1 stop5h 35m

Charleston

Fri 9/19

7:28 pm-11:06 pm

1 stop4h 38m

$236

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Sat 9/13

3:46 pm-9:31 pm

1 stop4h 45m

Savannah/Hilton Head

Sat 9/20

7:03 pm-11:06 pm

1 stop5h 03m

$236

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Tue 10/21

4:45 pm-9:30 pm

1 stop3h 45m

Charlotte Douglas

Thu 11/6

6:25 pm-11:35 pm

1 stop6h 10m

$236

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 10/5

5:44 am-11:48 am

1 stop5h 04m

Charleston

Sat 10/11

3:07 pm-9:03 pm

1 stop6h 56m

$237

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sun 9/14

5:44 am-1:28 pm

1 stop6h 44m

Greenville

Sun 9/21

7:35 am-10:40 am

1 stop4h 05m

$237

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Sat 8/30

8:35 am-4:35 pm

1 stop7h 00m

Charlotte Douglas

Wed 9/3

5:25 pm-10:20 pm

1 stop5h 55m

$242

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Wed 8/27

8:00 am-2:31 pm

1 stop5h 31m

Myrtle Beach Intl

Sat 8/30

3:45 pm-11:41 pm

1 stop8h 56m

$307

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Wed 12/17

8:00 am-2:27 pm

1 stop5h 27m

Savannah/Hilton Head

Wed 12/24

4:55 pm-9:40 pm

1 stop5h 45m

$307

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Des Moines to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Des Moines is in September. Flight prices, which tend to average around $334, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Des Moines during August instead. Flights to South Carolina in August, while not as cheap as those in September, still average around $340.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $379. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $508.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Des Moines to South Carolina flights are usually those with departure times in the afternoon. Our users have found flights to South Carolina in the afternoon for as low as $386. Try not to purchase tickets in the morning because they tend to be around $405. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $388 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Des Moines for as low as $321 on momondo.

Cheap Des Moines to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to South Carolina

Best Price Found

$113

Fastest flight time

2h 26m

Direct flights

Every day

Airports in South Carolina

7 airports
The best one-way flight to South Carolina from Des Moines in the past 72 hours is $113. The best round-trip flight deal from Des Moines to South Carolina found on momondo in the last 72 hours is $220.
The fastest flight from Des Moines to South Carolina takes 2h 26m
Direct flights go from Des Moines to South Carolina every day.
There are 7 airports near South Carolina: Greenville (GSP), Columbia Metropolitan (CAE), Myrtle Beach Intl (MYR), Savannah/Hilton Head (SAV), Hilton Head Island (HHH), Charlotte Douglas (CLT), Charleston (CHS)
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  • When did momondo last update prices for flights from Des Moines Airport to South Carolina?

    Prices for flights from Des Moines Airport to South Carolina refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to South Carolina?

  • How old do you have to be to fly from Des Moines Airport to South Carolina?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to South Carolina

Compare and see reviews for airlines that fly from Des Moines to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $237Free CancellationRating
8.0
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $254Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
SouthwestPriceFrom $272Free CancellationRating
8.0
4,246 reviews
Search Southwest flights
United AirlinesPriceFrom $315Free CancellationRating
7.4
8,900 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to South Carolina?

Finding the right flight to South Carolina from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South Carolina quick and easy, saving you time and money.

Can I find flights from Des Moines to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to South Carolina?

momondo helps you find the best flight between Des Moines and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your South Carolina trip

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