What airlines fly to South Carolina?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to South Carolina from Des Moines according to our data. American Airlines is the first choice among our users, with 58% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Des Moines to South Carolina?

Delta, United Airlines, and Southwest are the most popular carriers operating from Des Moines to South Carolina

When did momondo last update prices for flights from Des Moines Airport to South Carolina?

Prices for flights from Des Moines Airport to South Carolina refresh daily.

How many operators does momondo search for flights from Des Moines Airport to South Carolina?

There are 4 operators available for flights from Des Moines Airport to South Carolina as of September 2026.

How old do you have to be to fly from Des Moines Airport to South Carolina?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$163 Cheap Flights from Des Moines to South Carolina in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to South Carolina

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:00 am - 2:22 pmDSM Des Moines-CHS Charleston

7h 22m1 stop Fort Myers SW Florida Intl

8:35 pm - 9:45 pmCHS Charleston-DSM Des Moines

26h 10m1 stop Fort Lauderdale

$306Multiple Airlines

Mon, Jan 25 - Wed, Jan 27

2:26 pm - 11:38 pmDSM Des Moines-CAE Columbia Metropolitan

8h 12m1 stop Washington, D.C. Reagan-National

5:59 pm - 11:58 pmCAE Columbia Metropolitan-DSM Des Moines

6h 59m1 stop Charlotte Douglas

$315American Airlines

Wed, Oct 21 - Sat, Oct 24

11:27 am - 4:57 pmDSM Des Moines-CAE Columbia Metropolitan

4h 30m1 stop Chicago O'Hare Intl

6:15 am - 4:20 pmCAE Columbia Metropolitan-DSM Des Moines

11h 05m2 stops Chicago O'Hare Intl Denver Intl

$320United Airlines

Wed, Oct 21 - Sat, Oct 24

2:58 pm - 10:47 pmDSM Des Moines-MYR Myrtle Beach Intl

6h 49m1 stop Atlanta Hartsfield-Jackson

6:00 am - 10:49 amMYR Myrtle Beach Intl-DSM Des Moines

5h 49m1 stop Atlanta Hartsfield-Jackson

$325Delta

Wed, Dec 2 - Tue, Dec 8

2:58 pm - 10:47 pmDSM Des Moines-MYR Myrtle Beach Intl

6h 49m1 stop Atlanta Hartsfield-Jackson

2:18 pm - 6:06 pmMYR Myrtle Beach Intl-DSM Des Moines

4h 48m1 stop Atlanta Hartsfield-Jackson

$325Delta

Wed, Dec 2 - Mon, Dec 7

8:00 am - 1:56 pmDSM Des Moines-CHS Charleston

4h 56m1 stop Chicago O'Hare Intl

3:29 pm - 9:55 pmCHS Charleston-DSM Des Moines

7h 26m1 stop Chicago O'Hare Intl

$325United Airlines

Wed, Nov 4 - Sat, Nov 7

7:57 pm - 1:40 pmDSM Des Moines-GSP Greenville

16h 43m1 stop Orlando Sanford Intl

10:44 am - 11:55 amGSP Greenville-DSM Des Moines

26h 11m1 stop Orlando Sanford Intl

$325Allegiant Air

Fri, Oct 9 - Tue, Oct 13

4:12 pm - 10:52 pmDSM Des Moines-MYR Myrtle Beach Intl

5h 40m1 stop Dallas/Fort Worth

4:57 pm - 11:07 pmMYR Myrtle Beach Intl-DSM Des Moines

7h 10m1 stop Dallas/Fort Worth

$325American Airlines

Sat, Oct 17 - Sat, Oct 31

5:35 am - 1:30 pmDSM Des Moines-MYR Myrtle Beach Intl

6h 55m2 stops Chicago Midway Nashville Intl

7:50 am - 11:30 amMYR Myrtle Beach Intl-DSM Des Moines

4h 40m1 stop Chicago Midway

$330Southwest

Wed, Oct 21 - Wed, Oct 28

7:00 am - 4:30 pmDSM Des Moines-CHS Charleston

8h 30m2 stops Denver Intl Chicago Midway

9:45 am - 7:40 pmCHS Charleston-DSM Des Moines

10h 55m2 stops Nashville Intl Chicago Midway

$335Southwest

Wed, Dec 2 - Sat, Dec 5

Cheap last minute flights

Enter your travel dates to find the best prices.

5:56 pm - 12:03 amDSM Des Moines-CAE Columbia Metropolitan

5h 07m1 stop Chicago O'Hare Intl

6:25 am - 12:04 pmCAE Columbia Metropolitan-DSM Des Moines

6h 39m1 stop Charlotte Douglas

$389American Airlines

Wed, Sep 30 - Sat, Oct 3

5:56 pm - 12:03 amDSM Des Moines-CAE Columbia Metropolitan

5h 07m1 stop Chicago O'Hare Intl

8:18 am - 12:04 pmCAE Columbia Metropolitan-DSM Des Moines

4h 46m1 stop Charlotte Douglas

$389American Airlines

Tue, Sep 29 - Sat, Oct 3

5:45 am - 11:12 amDSM Des Moines-CAE Columbia Metropolitan

4h 27m1 stop Atlanta Hartsfield-Jackson

6:00 am - 10:46 amCAE Columbia Metropolitan-DSM Des Moines

5h 46m1 stop Atlanta Hartsfield-Jackson

$389Delta

Wed, Sep 30 - Sat, Oct 3

11:27 am - 4:57 pmDSM Des Moines-CAE Columbia Metropolitan

4h 30m1 stop Chicago O'Hare Intl

3:03 pm - 11:35 pmCAE Columbia Metropolitan-DSM Des Moines

9h 32m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$394United Airlines

Wed, Sep 30 - Sat, Oct 3

2:13 pm - 11:05 pmDSM Des Moines-CAE Columbia Metropolitan

7h 52m2 stops Washington, D.C. Reagan-National Charlotte Douglas

5:21 pm - 11:12 pmCAE Columbia Metropolitan-DSM Des Moines

6h 51m1 stop Dallas/Fort Worth

$410American Airlines

Wed, Sep 30 - Sat, Oct 3

1:24 pm - 9:09 pmDSM Des Moines-CAE Columbia Metropolitan

6h 45m1 stop Chicago O'Hare Intl

3:03 pm - 11:35 pmCAE Columbia Metropolitan-DSM Des Moines

9h 32m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$474United Airlines

Tue, Sep 29 - Sat, Oct 3

9:39 am - 4:10 pmDSM Des Moines-MYR Myrtle Beach Intl

29h 31m2 stops Nashville Intl Albany Intl

4:02 pm - 11:55 amMYR Myrtle Beach Intl-DSM Des Moines

20h 53m1 stop Orlando

$625Multiple Airlines

Sun, Sep 27 - Tue, Sep 29

5:45 am - 11:38 amDSM Des Moines-CHS Charleston

4h 53m1 stop Atlanta Hartsfield-Jackson

10:46 am - 3:15 pmCHS Charleston-DSM Des Moines

5h 29m1 stop Atlanta Hartsfield-Jackson

$662Delta

Wed, Sep 30 - Sat, Oct 3

5:40 am - 4:05 pmDSM Des Moines-GSP Greenville

9h 25m2 stops Chicago Midway Baltimore/Washington

2:10 pm - 11:10 pmGSP Greenville-DSM Des Moines

10h 00m2 stops Baltimore/Washington Chicago Midway

$742Southwest

Fri, Sep 25 - Fri, Oct 2

5:30 am - 2:55 pmDSM Des Moines-GSP Greenville

8h 25m2 stops Chicago Midway Nashville Intl

1:05 pm - 9:20 pmGSP Greenville-DSM Des Moines

9h 15m2 stops Nashville Intl Denver Intl

$797Southwest

Sat, Sep 26 - Mon, Sep 28

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American Airlines flights from Des Moines to South Carolina

Our best American Airlines deals on Des Moines to South Carolina flight tickets

American Airlines

Oct 21

DSM2:26 pmDes Moines

8h 12m

1 stop

CAE11:38 pmColumbia Metropolitan

Oct 24

CAE5:59 pmColumbia Metropolitan

6h 59m

1 stop

DSM11:58 pmDes Moines

$315

American Airlines

Nov 7

DSM11:09 amDes Moines

4h 14m

1 stop

MYR4:23 pmMyrtle Beach Intl

Nov 11

MYR5:03 pmMyrtle Beach Intl

7h 23m

1 stop

DSM11:26 pmDes Moines

$325

American Airlines

Oct 13

DSM6:00 amDes Moines

7h 45m

1 stop

MYR2:45 pmMyrtle Beach Intl

Oct 14

MYR8:01 pmMyrtle Beach Intl

4h 57m

1 stop

DSM11:58 pmDes Moines

$362

Delta flights from Des Moines to South Carolina

Our best Delta deals on Des Moines to South Carolina flight tickets

Delta

Nov 9

DSM2:59 pmDes Moines

6h 05m

1 stop

CHS10:04 pmCharleston

Nov 14

CHS6:00 amCharleston

5h 46m

1 stop

DSM10:46 amDes Moines

$325

Delta

Dec 16

DSM5:20 amDes Moines

4h 48m

1 stop

CAE11:08 amColumbia Metropolitan

Dec 20

CAE12:55 pmColumbia Metropolitan

5h 36m

1 stop

DSM5:31 pmDes Moines

$342

Delta

Nov 13

DSM2:51 pmDes Moines

6h 13m

1 stop

CHS10:04 pmCharleston

Nov 18

CHS3:23 pmCharleston

4h 52m

1 stop

DSM7:15 pmDes Moines

$350

momondo Fare Finder

Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Mon 1/25

6:00 am-2:22 pm

1 stop7h 22m

Charleston

Wed 1/27

8:35 pm-9:45 pm

1 stop26h 10m

$306

Des MoinesColumbia

DSM Des Moines - CAE Columbia Metropolitan

DSMCAE

Des Moines

Wed 10/21

2:26 pm-11:38 pm

1 stop8h 12m

Columbia Metropolitan

Sat 10/24

5:59 pm-11:58 pm

1 stop6h 59m

$315

Des MoinesColumbia

DSM Des Moines - CAE Columbia Metropolitan

DSMCAE

Des Moines

Wed 10/21

11:27 am-4:57 pm

1 stop4h 30m

Columbia Metropolitan

Sat 10/24

6:15 am-4:20 pm

2 stops11h 05m

$320

Des MoinesMyrtle Beach

DSM Des Moines - MYR Myrtle Beach Intl

DSMMYR

Des Moines

Wed 12/2

2:58 pm-10:47 pm

1 stop6h 49m

Myrtle Beach Intl

Tue 12/8

6:00 am-10:49 am

1 stop5h 49m

$325

Des MoinesMyrtle Beach

DSM Des Moines - MYR Myrtle Beach Intl

DSMMYR

Des Moines

Wed 12/2

2:58 pm-10:47 pm

1 stop6h 49m

Myrtle Beach Intl

Mon 12/7

2:18 pm-6:06 pm

1 stop4h 48m

$325

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Wed 11/4

8:00 am-1:56 pm

1 stop4h 56m

Charleston

Sat 11/7

3:29 pm-9:55 pm

1 stop7h 26m

$325

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Fri 10/9

7:57 pm-1:40 pm

1 stop16h 43m

Greenville

Tue 10/13

10:44 am-11:55 am

1 stop26h 11m

$325

Des MoinesMyrtle Beach

DSM Des Moines - MYR Myrtle Beach Intl

DSMMYR

Des Moines

Sat 10/17

4:12 pm-10:52 pm

1 stop5h 40m

Myrtle Beach Intl

Sat 10/31

4:57 pm-11:07 pm

1 stop7h 10m

$325

Quickest round-trip

Des MoinesMyrtle Beach

DSM Des Moines - MYR Myrtle Beach Intl

DSMMYR

Des Moines

Wed 10/21

5:35 am-1:30 pm

2 stops6h 55m

Myrtle Beach Intl

Wed 10/28

7:50 am-11:30 am

1 stop4h 40m

$330

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Wed 12/2

7:00 am-4:30 pm

2 stops8h 30m

Charleston

Sat 12/5

9:45 am-7:40 pm

2 stops10h 55m

$335

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Des Moines is in September. Flight prices, which tend to average around $381, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Des Moines during January instead. Flights to South Carolina in January, while not as cheap as those in September, still average around $386.

Can stopping save me money on Des Moines to South Carolina flights?

You could potentially save up to 3% on your flight if you consider stops on a Des Moines to South Carolina flight.

Cheap Des Moines to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to South Carolina

Best Price Found	$163
Fastest flight time	2h 22m
Direct flights	None

The best one-way flight to South Carolina from Des Moines in the past 72 hours is $163. The best round-trip flight deal from Des Moines to South Carolina found on momondo in the last 72 hours is $306.

The fastest flight from Des Moines to South Carolina takes 2h 22m

There are no direct flights from Des Moines to South Carolina. There are no popular flight routes from Des Moines to South Carolina.

Search flight deals

Frequently asked questions about flying from Des Moines to South Carolina

When did momondo last update prices for flights from Des Moines Airport to South Carolina?
Prices for flights from Des Moines Airport to South Carolina refresh daily.
How many operators does momondo search for flights from Des Moines Airport to South Carolina?
There are 4 operators available for flights from Des Moines Airport to South Carolina as of September 2026.
How old do you have to be to fly from Des Moines Airport to South Carolina?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to South Carolina

Compare and see reviews for airlines that fly from Des Moines to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $266	Free Cancellation	Rating 7.4 10,233 reviews	Search United Airlines flights
American Airlines	PriceFrom $292	Free Cancellation	Rating 7.0 12,075 reviews	Search American Airlines flights
Delta	PriceFrom $308	Free Cancellation	Rating 7.8 8,595 reviews	Search Delta flights
Southwest	PriceFrom $344	Free Cancellation	Rating 8.0 4,199 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to South Carolina?

Finding the right flight to South Carolina from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South Carolina quick and easy, saving you time and money.

Can I find flights from Des Moines to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to South Carolina?

momondo helps you find the best flight between Des Moines and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.