How many flights depart from Des Moines to South Carolina on average per week?

12 flights are operational weekly from Des Moines to South Carolina as of March 2026. The most popular departure day for this route is Mon, with 17% of flights per week taking off on this day.

What airlines fly to South Carolina?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to South Carolina from Des Moines according to our data. American Airlines is the first choice among our users, with 71% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Des Moines to South Carolina?

American Airlines, Southwest, and Delta are the most popular carriers operating from Des Moines to South Carolina

When did momondo last update prices for flights from Des Moines Airport to South Carolina?

Prices for flights from Des Moines Airport to South Carolina refresh daily.

How many operators does momondo search for flights from Des Moines Airport to South Carolina?

There are 4 operators available for flights from Des Moines Airport to South Carolina as of March 2026.

How old do you have to be to fly from Des Moines Airport to South Carolina?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$102 Cheap Flights from Des Moines to South Carolina in 2026

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Find the cheapest flights from Des Moines to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

2:04 pm - 4:56 pm

DSM

CLT

25h 52m

1 stop

5:20 pm - 1:31 pm

CLT

DSM

21h 11m

1 stop

$171Frontier

Fri, May 1 - Tue, May 5

2:04 pm - 4:56 pm

DSM

CLT

25h 52m

1 stop

5:20 pm - 1:31 pm

CLT

DSM

21h 11m

1 stop

$192Frontier

Fri, May 1 - Tue, May 5

5:44 am - 12:04 pm

DSM

MYR

5h 20m

1 stop

8:14 am - 12:52 pm

MYR

DSM

5h 38m

1 stop

$263American Airlines

Wed, Apr 15 - Tue, Apr 21

3:01 pm - 10:15 pm

DSM

CHS

6h 14m

1 stop

6:30 pm - 11:16 pm

CHS

DSM

5h 46m

1 stop

$263United Airlines

Wed, May 27 - Tue, Jun 2

5:44 am - 12:04 pm

DSM

MYR

5h 20m

1 stop

12:19 pm - 8:21 pm

MYR

DSM

9h 02m

2 stops

$268American Airlines

Wed, Apr 15 - Tue, Apr 21

5:00 am - 2:27 pm

DSM

CHS

8h 27m

2 stops

6:00 am - 10:27 am

CHS

DSM

5h 27m

1 stop

$268United Airlines

Wed, May 27 - Tue, Jun 2

6:10 am - 11:55 am

DSM

MYR

4h 45m

1 stop

3:57 pm - 9:12 pm

MYR

DSM

6h 15m

1 stop

$287Delta

Wed, Apr 15 - Wed, Apr 22

6:31 pm - 11:59 pm

DSM

SAV

4h 28m

1 stop

6:50 am - 11:05 am

SAV

DSM

5h 15m

1 stop

$290Delta

Wed, Apr 22 - Sat, Apr 25

5:35 am - 4:40 pm

DSM

SAV

10h 05m

2 stops

7:15 am - 11:30 am

SAV

DSM

5h 15m

1 stop

$323Southwest

Sat, May 9 - Sat, May 16

5:25 am - 5:05 pm

DSM

CHS

10h 40m

2 stops

7:40 am - 11:45 am

CHS

DSM

5h 05m

1 stop

$329Southwest

Mon, May 18 - Thu, May 28

Southwest flights from Des Moines to South Carolina

Our best Southwest deals on Des Moines to South Carolina flight tickets

Southwest

May 9

DSM5:35 amDes Moines

10h 05m

2 stops

SAV4:40 pmSavannah/Hilton Head

May 16

SAV7:15 amSavannah/Hilton Head

5h 15m

1 stop

DSM11:30 amDes Moines

$323

Southwest

May 18

DSM5:25 amDes Moines

10h 40m

2 stops

CHS5:05 pmCharleston

May 28

CHS7:40 amCharleston

5h 05m

1 stop

DSM11:45 amDes Moines

$329

Southwest

May 9

DSM5:35 amDes Moines

10h 05m

2 stops

SAV4:40 pmSavannah/Hilton Head

May 16

SAV7:15 amSavannah/Hilton Head

14h 40m

2 stops

DSM8:55 pmDes Moines

$334

United Airlines flights from Des Moines to South Carolina

Our best United Airlines deals on Des Moines to South Carolina flight tickets

United Airlines

May 27

DSM3:01 pmDes Moines

6h 14m

1 stop

CHS10:15 pmCharleston

Jun 2

CHS6:30 pmCharleston

5h 46m

1 stop

DSM11:16 pmDes Moines

$263

United Airlines

May 27

DSM5:00 amDes Moines

8h 27m

2 stops

CHS2:27 pmCharleston

Jun 2

CHS6:00 amCharleston

5h 27m

1 stop

DSM10:27 amDes Moines

$268

United Airlines

Apr 28

DSM8:04 amDes Moines

9h 11m

2 stops

SAV6:15 pmSavannah/Hilton Head

Apr 30

SAV6:00 amSavannah/Hilton Head

5h 37m

1 stop

DSM10:37 amDes Moines

$295

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Fri 5/1

2:04 pm-4:56 pm

1 stop25h 52m

Charlotte Douglas

Tue 5/5

5:20 pm-1:31 pm

1 stop21h 11m

$171

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Fri 5/1

2:04 pm-4:56 pm

1 stop25h 52m

Charlotte Douglas

Tue 5/5

5:20 pm-1:31 pm

1 stop21h 11m

$192

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Wed 4/15

5:44 am-12:04 pm

1 stop5h 20m

Myrtle Beach Intl

Tue 4/21

8:14 am-12:52 pm

1 stop5h 38m

$263

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 5/27

3:01 pm-10:15 pm

1 stop6h 14m

Charleston

Tue 6/2

6:30 pm-11:16 pm

1 stop5h 46m

$263

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Wed 4/15

5:44 am-12:04 pm

1 stop5h 20m

Myrtle Beach Intl

Tue 4/21

12:19 pm-8:21 pm

2 stops9h 02m

$268

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 5/27

5:00 am-2:27 pm

2 stops8h 27m

Charleston

Tue 6/2

6:00 am-10:27 am

1 stop5h 27m

$268

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Wed 4/15

6:10 am-11:55 am

1 stop4h 45m

Myrtle Beach Intl

Wed 4/22

3:57 pm-9:12 pm

1 stop6h 15m

$287

Quickest round-trip

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Wed 4/22

6:31 pm-11:59 pm

1 stop4h 28m

Savannah/Hilton Head

Sat 4/25

6:50 am-11:05 am

1 stop5h 15m

$290

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Sat 5/9

5:35 am-4:40 pm

2 stops10h 05m

Savannah/Hilton Head

Sat 5/16

7:15 am-11:30 am

1 stop5h 15m

$323

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 5/18

5:25 am-5:05 pm

2 stops10h 40m

Charleston

Thu 5/28

7:40 am-11:45 am

1 stop5h 05m

$329

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Des Moines is in September. Flight prices, which tend to average around $281, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Des Moines during January instead. Flights to South Carolina in January, while not as cheap as those in September, still average around $310.

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $389 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Des Moines for as low as $274 on momondo.

Can stopping save me money on Des Moines to South Carolina flights?

You could potentially save up to 25% on your flight if you consider stops on a Des Moines to South Carolina flight.

Cheap Des Moines to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to South Carolina

Fastest flight time	2h 26m
Direct flights	Every day
Airports in South Carolina	57 airports

The fastest flight from Des Moines to South Carolina takes 2h 26m

Direct flights go from Des Moines to South Carolina every day.

There are 57 airports in South Carolina. From Des Moines there are direct flights to Charlotte Douglas (CLT).

Search flight deals

When did momondo last update prices for flights from Des Moines Airport to South Carolina?
Prices for flights from Des Moines Airport to South Carolina refresh daily.
How many operators does momondo search for flights from Des Moines Airport to South Carolina?
There are 4 operators available for flights from Des Moines Airport to South Carolina as of March 2026.
How old do you have to be to fly from Des Moines Airport to South Carolina?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to South Carolina

Compare and see reviews for airlines that fly from Des Moines to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $148	Free Cancellation	Rating 7.9 8,359 reviews	Search Delta flights
American Airlines	PriceFrom $242	Free Cancellation	Rating 7.1 11,530 reviews	Search American Airlines flights
United Airlines	PriceFrom $266	Free Cancellation	Rating 7.4 9,514 reviews	Search United Airlines flights
Southwest	PriceFrom $272	Free Cancellation	Rating 8.0 4,329 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to South Carolina?

Finding the right flight to South Carolina from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South Carolina quick and easy, saving you time and money.

Can I find flights from Des Moines to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to South Carolina?

momondo helps you find the best flight between Des Moines and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.