What is the cheapest airline that flies from Des Moines to South Carolina?

Allegiant Air, Frontier, and American Airlines are the most popular carriers operating from Des Moines to South Carolina

How many flights depart from Des Moines to South Carolina on average per week?

14 flights are operational weekly from Des Moines to South Carolina as of July 2026. The most popular departure day for this route is Mon, with 14% of flights per week taking off on this day.

What airlines fly to South Carolina?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to South Carolina from Des Moines according to our data. American Airlines is the first choice among our users, with 61% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to South Carolina?

Prices for flights from Des Moines Airport to South Carolina refresh daily.

How many operators does momondo search for flights from Des Moines Airport to South Carolina?

There are 4 operators available for flights from Des Moines Airport to South Carolina as of July 2026.

How old do you have to be to fly from Des Moines Airport to South Carolina?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$120 Cheap Flights from Des Moines to South Carolina in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

3:54 pm - 7:58 am

DSM

MYR

15h 04m

1 stop

8:35 am - 2:42 pm

MYR

DSM

7h 07m

1 stop

$223Multiple Airlines

Sun, Oct 11 - Thu, Oct 15

11:29 am - 6:59 pm

DSM

CLT

6h 30m

1 stop

7:54 pm - 7:33 pm

CLT

DSM

24h 39m

1 stop

$257Frontier

Thu, Sep 24 - Thu, Oct 1

2:13 pm - 11:15 pm

DSM

CAE

8h 02m

1 stop

5:21 pm - 11:12 pm

CAE

DSM

6h 51m

1 stop

$295American Airlines

Wed, Sep 9 - Fri, Sep 11

8:10 am - 3:31 pm

DSM

CAE

6h 21m

1 stop

1:51 pm - 6:41 pm

CAE

DSM

5h 50m

1 stop

$297American Airlines

Wed, Aug 19 - Wed, Aug 26

8:00 am - 7:07 pm

DSM

CAE

10h 07m

2 stops

6:25 am - 10:26 am

CAE

DSM

5h 01m

1 stop

$312United Airlines

Wed, Aug 19 - Wed, Aug 26

6:54 pm - 11:47 pm

DSM

CAE

3h 53m

1 stop

7:00 am - 10:42 am

CAE

DSM

4h 42m

1 stop

$319Delta

Thu, Oct 22 - Sun, Oct 25

12:10 pm - 6:10 pm

DSM

CLT

5h 00m

1 stop

3:25 pm - 7:25 pm

CLT

DSM

5h 00m

1 stop

$321Southwest

Sat, Sep 5 - Sat, Sep 12

6:21 am - 2:13 pm

DSM

CHS

6h 52m

2 stops

5:00 pm - 9:35 pm

CHS

DSM

5h 35m

1 stop

$322United Airlines

Thu, Nov 12 - Mon, Nov 16

4:11 pm - 10:01 pm

DSM

CHS

4h 50m

1 stop

6:05 am - 10:46 am

CHS

DSM

5h 41m

1 stop

$326Delta

Sun, Sep 6 - Wed, Sep 9

12:10 pm - 6:10 pm

DSM

CLT

5h 00m

1 stop

10:30 am - 8:45 pm

CLT

DSM

11h 15m

2 stops

$326Southwest

Sat, Sep 5 - Sat, Sep 12

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Frontier flights from Des Moines to South Carolina

Our best Frontier deals on Des Moines to South Carolina flight tickets

Frontier

Sep 24

DSM11:29 amDes Moines

6h 30m

1 stop

CLT6:59 pmCharlotte Douglas

Oct 1

CLT7:54 pmCharlotte Douglas

24h 39m

1 stop

DSM7:33 pmDes Moines

$257

Frontier

Sep 13

DSM11:29 amDes Moines

6h 30m

1 stop

CLT6:59 pmCharlotte Douglas

Sep 17

CLT7:54 pmCharlotte Douglas

24h 39m

1 stop

DSM7:33 pmDes Moines

$265

Frontier

Sep 24

DSM11:29 amDes Moines

6h 30m

1 stop

CLT6:59 pmCharlotte Douglas

Sep 27

CLT7:54 pmCharlotte Douglas

24h 39m

1 stop

DSM7:33 pmDes Moines

$305

Southwest flights from Des Moines to South Carolina

Our best Southwest deals on Des Moines to South Carolina flight tickets

Southwest

Sep 5

DSM12:10 pmDes Moines

5h 00m

1 stop

CLT6:10 pmCharlotte Douglas

Sep 12

CLT3:25 pmCharlotte Douglas

5h 00m

1 stop

DSM7:25 pmDes Moines

$321

Southwest

Nov 12

DSM6:40 amDes Moines

12h 35m

1 stop

CHS8:15 pmCharleston

Nov 16

CHS7:55 amCharleston

4h 35m

1 stop

DSM11:30 amDes Moines

$322

Southwest

Sep 5

DSM12:10 pmDes Moines

5h 00m

1 stop

CLT6:10 pmCharlotte Douglas

Sep 12

CLT10:30 amCharlotte Douglas

11h 15m

2 stops

DSM8:45 pmDes Moines

$326

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Sun 10/11

3:54 pm-7:58 am

1 stop15h 04m

Myrtle Beach Intl

Thu 10/15

8:35 am-2:42 pm

1 stop7h 07m

$223

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Thu 9/24

11:29 am-6:59 pm

1 stop6h 30m

Charlotte Douglas

Thu 10/1

7:54 pm-7:33 pm

1 stop24h 39m

$257

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Wed 9/9

2:13 pm-11:15 pm

1 stop8h 02m

Columbia Metropolitan

Fri 9/11

5:21 pm-11:12 pm

1 stop6h 51m

$295

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Wed 8/19

8:10 am-3:31 pm

1 stop6h 21m

Columbia Metropolitan

Wed 8/26

1:51 pm-6:41 pm

1 stop5h 50m

$297

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Wed 8/19

8:00 am-7:07 pm

2 stops10h 07m

Columbia Metropolitan

Wed 8/26

6:25 am-10:26 am

1 stop5h 01m

$312

Quickest round-trip

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Thu 10/22

6:54 pm-11:47 pm

1 stop3h 53m

Columbia Metropolitan

Sun 10/25

7:00 am-10:42 am

1 stop4h 42m

$319

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Sat 9/5

12:10 pm-6:10 pm

1 stop5h 00m

Charlotte Douglas

Sat 9/12

3:25 pm-7:25 pm

1 stop5h 00m

$321

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Thu 11/12

6:21 am-2:13 pm

2 stops6h 52m

Charleston

Mon 11/16

5:00 pm-9:35 pm

1 stop5h 35m

$322

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 9/6

4:11 pm-10:01 pm

1 stop4h 50m

Charleston

Wed 9/9

6:05 am-10:46 am

1 stop5h 41m

$326

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Sat 9/5

12:10 pm-6:10 pm

1 stop5h 00m

Charlotte Douglas

Sat 9/12

10:30 am-8:45 pm

2 stops11h 15m

$326

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Des Moines is in September. Flight prices, which tend to average around $357, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Des Moines during January instead. Flights to South Carolina in January, while not as cheap as those in September, still average around $386.

Can stopping save me money on Des Moines to South Carolina flights?

You could potentially save up to 32% on your flight if you consider stops on a Des Moines to South Carolina flight.

Cheap Des Moines to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to South Carolina

Fastest flight time	2h 22m
Direct flights	Mon, Wed, Thu, Fri, Sat and Sun
Airports in South Carolina	57 airports

The fastest flight from Des Moines to South Carolina takes 2h 22m

Direct flights go from Des Moines to South Carolina on Monday, Wednesday, Thursday, Friday, Saturday and Sunday. There are no airlines offering direct flights.

There are 57 airports in South Carolina. From Des Moines there are direct flights to Charlotte Douglas (CLT).

Search flight deals

Frequently asked questions about flying from Des Moines to South Carolina

When did momondo last update prices for flights from Des Moines Airport to South Carolina?
Prices for flights from Des Moines Airport to South Carolina refresh daily.
How many operators does momondo search for flights from Des Moines Airport to South Carolina?
There are 4 operators available for flights from Des Moines Airport to South Carolina as of July 2026.
How old do you have to be to fly from Des Moines Airport to South Carolina?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Des Moines to South Carolina

Compare and see reviews for airlines that fly from Des Moines to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $233	Free Cancellation	Rating 7.8 8,490 reviews	Search Delta flights
American Airlines	PriceFrom $262	Free Cancellation	Rating 7.1 11,848 reviews	Search American Airlines flights
United Airlines	PriceFrom $266	Free Cancellation	Rating 7.4 10,043 reviews	Search United Airlines flights
Southwest	PriceFrom $344	Free Cancellation	Rating 8.0 4,229 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to South Carolina?

Finding the right flight to South Carolina from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South Carolina quick and easy, saving you time and money.

Can I find flights from Des Moines to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to South Carolina?

momondo helps you find the best flight between Des Moines and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.