What is the cheapest airline that flies from Des Moines to South America?

Avianca, United Airlines, and LATAM Airlines are the most popular carriers operating from Des Moines to South America

What airlines fly to South America?

Delta, LATAM Airlines and American Airlines are the top three most popular airlines that fly to South America from Des Moines according to our data. Delta is the first choice among our users, with 50% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 3 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to South America?

Prices for flights from Des Moines Airport to South America were last updated today.

How many operators does momondo search for flights from Des Moines Airport to South America?

As of August 2026, there are 3 operators available to choose from for flights from Des Moines Airport to South America.

How old do you have to be to fly from Des Moines Airport to South America?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to South America.

What documentation or ID do you need to fly to South America?

The travel and health documents you'll need for your trip to South America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$320 Cheap Flights from Des Moines to South America in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

7:58 pm - 12:35 pmDSM Des Moines-CTG Cartagena Rafael Nunez

16h 37m2 stops Chicago O'Hare Intl Miami

1:35 pm - 11:36 pmCTG Cartagena Rafael Nunez-DSM Des Moines

10h 01m1 stop Miami

$650American Airlines

Sat, Oct 3 - Sat, Oct 10

4:14 pm - 12:35 pmDSM Des Moines-CTG Cartagena Rafael Nunez

20h 21m2 stops Dallas/Fort Worth Miami

1:35 pm - 1:30 pmCTG Cartagena Rafael Nunez-DSM Des Moines

23h 55m2 stops Miami Chicago O'Hare Intl

$664American Airlines

Sat, Oct 3 - Sat, Oct 10

2:13 pm - 12:35 pmDSM Des Moines-CTG Cartagena Rafael Nunez

22h 22m2 stops Washington, D.C. Reagan-National Miami

1:35 pm - 12:45 pmCTG Cartagena Rafael Nunez-DSM Des Moines

23h 10m2 stops Miami Philadelphia

$719American Airlines

Fri, Oct 2 - Fri, Oct 9

5:45 am - 1:15 pmDSM Des Moines-CTG Cartagena Rafael Nunez

7h 30m1 stop Atlanta Hartsfield-Jackson

2:30 pm - 10:33 pmCTG Cartagena Rafael Nunez-DSM Des Moines

8h 03m1 stop Atlanta Hartsfield-Jackson

$728Delta

Sat, Oct 3 - Sat, Oct 10

5:35 am - 1:15 pmDSM Des Moines-CTG Cartagena Rafael Nunez

7h 40m1 stop Atlanta Hartsfield-Jackson

4:00 am - 10:33 pmCTG Cartagena Rafael Nunez-DSM Des Moines

19h 33m2 stops Bogotá El Dorado Atlanta Hartsfield-Jackson

$737Delta

Thu, Oct 29 - Sun, Nov 1

6:55 pm - 8:40 amDSM Des Moines-UIO Quito Mariscal Sucr

13h 45m2 stops Chicago O'Hare Intl Bogotá El Dorado

10:10 am - 10:26 amUIO Quito Mariscal Sucr-DSM Des Moines

24h 16m2 stops Bogotá El Dorado Chicago O'Hare Intl

$751Multiple Airlines

Thu, Oct 22 - Sun, Oct 25

6:55 pm - 8:40 amDSM Des Moines-UIO Quito Mariscal Sucr

13h 45m2 stops Chicago O'Hare Intl Bogotá El Dorado

10:05 am - 10:26 amUIO Quito Mariscal Sucr-DSM Des Moines

24h 21m2 stops Bogotá El Dorado Chicago O'Hare Intl

$751Multiple Airlines

Thu, Oct 22 - Sun, Oct 25

5:35 am - 6:59 pmDSM Des Moines-UIO Quito Mariscal Sucr

13h 24m1 stop Atlanta Hartsfield-Jackson

11:45 pm - 10:42 amUIO Quito Mariscal Sucr-DSM Des Moines

10h 57m1 stop Atlanta Hartsfield-Jackson

$763Delta

Thu, Oct 22 - Wed, Oct 28

5:45 am - 9:20 pmDSM Des Moines-LIM Lima J Chavez Intl

14h 35m1 stop Atlanta Hartsfield-Jackson

9:35 am - 10:29 pmLIM Lima J Chavez Intl-DSM Des Moines

13h 54m2 stops Cartagena Rafael Nunez Atlanta Hartsfield-Jackson

$945LATAM Airlines

Mon, Feb 1 - Fri, Feb 5

5:45 am - 9:05 pmDSM Des Moines-LIM Lima J Chavez Intl

14h 20m2 stops Atlanta Hartsfield-Jackson Cartagena Rafael Nunez

9:35 am - 10:29 pmLIM Lima J Chavez Intl-DSM Des Moines

13h 54m2 stops Cartagena Rafael Nunez Atlanta Hartsfield-Jackson

$945LATAM Airlines

Mon, Feb 1 - Fri, Feb 5

Cheap last minute flights

Enter your travel dates to find the best prices.

1:08 pm - 11:05 amDSM Des Moines-EZE Buenos Aires Ministro Pistarini

19h 57m2 stops Charlotte Douglas New York John F Kennedy Intl

8:50 pm - 12:24 pmEZE Buenos Aires Ministro Pistarini-DSM Des Moines

17h 34m2 stops Miami Charlotte Douglas

$1,110American Airlines

Wed, Aug 26 - Tue, Sep 1

3:02 pm - 8:00 amDSM Des Moines-EZE Buenos Aires Ministro Pistarini

14h 58m1 stop Houston George Bush Intcntl

9:00 pm - 2:16 pmEZE Buenos Aires Ministro Pistarini-DSM Des Moines

19h 16m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$1,156United Airlines

Wed, Aug 26 - Tue, Sep 1

2:54 pm - 5:40 amDSM Des Moines-GRU Sao Paulo Guarulhos Intl

12h 46m1 stop Atlanta Hartsfield-Jackson

11:30 pm - 10:37 pmGRU Sao Paulo Guarulhos Intl-DSM Des Moines

25h 07m2 stops Miami Atlanta Hartsfield-Jackson

$1,376LATAM Airlines

Sun, Aug 23 - Sun, Aug 30

8:00 am - 10:26 pmDSM Des Moines-EZE Buenos Aires Ministro Pistarini

36h 26m2 stops Chicago O'Hare Intl Panama City Tocumen Intl

8:59 am - 10:26 amEZE Buenos Aires Ministro Pistarini-DSM Des Moines

27h 27m2 stops Panama City Tocumen Intl Chicago O'Hare Intl

$1,379Copa Airlines

Sun, Aug 23 - Tue, Aug 25

6:35 pm - 9:40 amDSM Des Moines-EZE Buenos Aires Ministro Pistarini

37h 05m2 stops Atlanta Hartsfield-Jackson Miami

8:10 pm - 10:43 amEZE Buenos Aires Ministro Pistarini-DSM Des Moines

16h 33m1 stop Atlanta Hartsfield-Jackson

$1,440LATAM Airlines

Sun, Aug 23 - Tue, Aug 25

6:35 pm - 8:00 pmDSM Des Moines-GRU Sao Paulo Guarulhos Intl

23h 25m2 stops Atlanta Hartsfield-Jackson Miami

11:45 pm - 10:37 pmGRU Sao Paulo Guarulhos Intl-DSM Des Moines

24h 52m2 stops Bogotá El Dorado Atlanta Hartsfield-Jackson

$1,471LATAM Airlines

Sun, Aug 23 - Sun, Aug 30

6:35 pm - 5:40 amDSM Des Moines-GRU Sao Paulo Guarulhos Intl

33h 05m1 stop Atlanta Hartsfield-Jackson

10:50 pm - 10:37 pmGRU Sao Paulo Guarulhos Intl-DSM Des Moines

25h 47m1 stop Atlanta Hartsfield-Jackson

$1,571Delta

Sun, Aug 23 - Sun, Aug 30

9:32 am - 2:55 pmDSM Des Moines-CNF Belo Horizonte Tancredo Neves Intl

27h 23m2 stops Dallas/Fort Worth Sao Paulo Guarulhos Intl

7:10 pm - 6:55 pmCNF Belo Horizonte Tancredo Neves Intl-DSM Des Moines

25h 45m2 stops Sao Paulo Guarulhos Intl Dallas/Fort Worth

$2,097American Airlines

Mon, Aug 24 - Wed, Aug 26

6:22 pm - 2:55 pmDSM Des Moines-CNF Belo Horizonte Tancredo Neves Intl

18h 33m2 stops Dallas/Fort Worth Sao Paulo Guarulhos Intl

3:45 pm - 1:25 pmCNF Belo Horizonte Tancredo Neves Intl-DSM Des Moines

23h 40m3 stops Sao Paulo Guarulhos Intl Miami Chicago O'Hare Intl

$2,188GOL

Mon, Aug 24 - Wed, Aug 26

1:09 pm - 2:55 pmDSM Des Moines-CNF Belo Horizonte Tancredo Neves Intl

23h 46m3 stops Philadelphia Miami Sao Paulo Guarulhos Intl

7:10 pm - 1:25 pmCNF Belo Horizonte Tancredo Neves Intl-DSM Des Moines

20h 15m3 stops Sao Paulo Guarulhos Intl New York John F Kennedy Intl Chicago O'Hare Intl

$2,189GOL

Mon, Aug 24 - Wed, Aug 26

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GOL flights from Des Moines to South America

Our best GOL deals on Des Moines to South America flight tickets

GOL

Nov 22

DSM6:00 amDes Moines

15h 18m

2 stops

UIO10:18 pmQuito Mariscal Sucr

Nov 27

UIO12:55 amQuito Mariscal Sucr

24h 08m

2 stops

DSM12:03 amDes Moines

$981

GOL

Dec 28

DSM8:05 pmDes Moines

26h 16m

2 stops

LIM11:21 pmLima J Chavez Intl

Jan 10

LIM12:45 amLima J Chavez Intl

23h 44m

1 stop

DSM11:29 pmDes Moines

$1,108

GOL

Nov 22

DSM6:02 amDes Moines

13h 42m

2 stops

UIO8:44 pmQuito Mariscal Sucr

Nov 27

UIO12:55 amQuito Mariscal Sucr

23h 54m

1 stop

DSM11:49 pmDes Moines

$1,142

LATAM Airlines flights from Des Moines to South America

Our best LATAM Airlines deals on Des Moines to South America flight tickets

LATAM Airlines

Feb 7

DSM5:15 pmDes Moines

24h 37m

2 stops

UIO6:52 pmQuito Mariscal Sucr

Feb 9

UIO12:55 amQuito Mariscal Sucr

10h 23m

1 stop

DSM10:18 amDes Moines

$842

LATAM Airlines

Jan 3

DSM6:30 pmDes Moines

47h 22m

2 stops

UIO6:52 pmQuito Mariscal Sucr

Jan 16

UIO8:55 amQuito Mariscal Sucr

26h 23m

2 stops

DSM10:18 amDes Moines

$897

LATAM Airlines

Jan 7

DSM5:15 pmDes Moines

24h 37m

2 stops

UIO6:52 pmQuito Mariscal Sucr

Jan 15

UIO12:55 amQuito Mariscal Sucr

16h 32m

1 stop

DSM4:27 pmDes Moines

$898

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesCartagena

DSM Des Moines - CTG Cartagena Rafael Nunez

DSMCTG

Des Moines

Sat 10/3

7:58 pm-12:35 pm

2 stops16h 37m

Cartagena Rafael Nunez

Sat 10/10

1:35 pm-11:36 pm

1 stop10h 01m

$650

Des MoinesCartagena

DSM Des Moines - CTG Cartagena Rafael Nunez

DSMCTG

Des Moines

Sat 10/3

4:14 pm-12:35 pm

2 stops20h 21m

Cartagena Rafael Nunez

Sat 10/10

1:35 pm-1:30 pm

2 stops23h 55m

$664

Des MoinesCartagena

DSM Des Moines - CTG Cartagena Rafael Nunez

DSMCTG

Des Moines

Fri 10/2

2:13 pm-12:35 pm

2 stops22h 22m

Cartagena Rafael Nunez

Fri 10/9

1:35 pm-12:45 pm

2 stops23h 10m

$719

Quickest round-trip

Des MoinesCartagena

DSM Des Moines - CTG Cartagena Rafael Nunez

DSMCTG

Des Moines

Sat 10/3

5:45 am-1:15 pm

1 stop7h 30m

Cartagena Rafael Nunez

Sat 10/10

2:30 pm-10:33 pm

1 stop8h 03m

$728

Des MoinesCartagena

DSM Des Moines - CTG Cartagena Rafael Nunez

DSMCTG

Des Moines

Thu 10/29

5:35 am-1:15 pm

1 stop7h 40m

Cartagena Rafael Nunez

Sun 11/1

4:00 am-10:33 pm

2 stops19h 33m

$737

Des MoinesQuito

DSM Des Moines - UIO Quito Mariscal Sucr

DSMUIO

Des Moines

Thu 10/22

6:55 pm-8:40 am

2 stops13h 45m

Quito Mariscal Sucr

Sun 10/25

10:10 am-10:26 am

2 stops24h 16m

$751

Des MoinesQuito

DSM Des Moines - UIO Quito Mariscal Sucr

DSMUIO

Des Moines

Thu 10/22

6:55 pm-8:40 am

2 stops13h 45m

Quito Mariscal Sucr

Sun 10/25

10:05 am-10:26 am

2 stops24h 21m

$751

Des MoinesQuito

DSM Des Moines - UIO Quito Mariscal Sucr

DSMUIO

Des Moines

Thu 10/22

5:35 am-6:59 pm

1 stop13h 24m

Quito Mariscal Sucr

Wed 10/28

11:45 pm-10:42 am

1 stop10h 57m

$763

Des MoinesLima

DSM Des Moines - LIM Lima J Chavez Intl

DSMLIM

Des Moines

Mon 2/1

5:45 am-9:20 pm

1 stop14h 35m

Lima J Chavez Intl

Fri 2/5

9:35 am-10:29 pm

2 stops13h 54m

$945

Des MoinesLima

DSM Des Moines - LIM Lima J Chavez Intl

DSMLIM

Des Moines

Mon 2/1

5:45 am-9:05 pm

2 stops14h 20m

Lima J Chavez Intl

Fri 2/5

9:35 am-10:29 pm

2 stops13h 54m

$945

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from Des Moines to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $643. If you aren’t able to travel during the month of February, then book flights to South America from Des Moines during September instead. Flights to South America in September, while not as cheap as those in February, still average around $725.

Can stopping save me money on Des Moines to South America flights?

You could potentially save up to 8% on your flight if you consider stops on a Des Moines to South America flight.

Cheap Des Moines to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to South America

Best Price Found	$320
Fastest flight time	7h 30m
Direct flights	None

The best one-way flight to South America from Des Moines in the past 72 hours is $320. The best round-trip flight deal from Des Moines to South America found on momondo in the last 72 hours is $650.

The fastest flight from Des Moines to South America takes 7h 30m

There are no direct flights from Des Moines to South America. There are no popular flight routes from Des Moines to South America.

Search flight deals

Frequently asked questions about flying from Des Moines to South America

When did momondo last update prices for flights from Des Moines Airport to South America?
Prices for flights from Des Moines Airport to South America were last updated today.
How many operators does momondo search for flights from Des Moines Airport to South America?
As of August 2026, there are 3 operators available to choose from for flights from Des Moines Airport to South America.
How old do you have to be to fly from Des Moines Airport to South America?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to South America.
What documentation or ID do you need to fly to South America?
The travel and health documents you'll need for your trip to South America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to South America

Compare and see reviews for airlines that fly from Des Moines to South America with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $607	Free Cancellation	Rating 7.8 8,518 reviews	Search Delta flights
LATAM Airlines	PriceFrom $688	Free Cancellation	Rating 7.4 1,990 reviews	Search LATAM Airlines flights
American Airlines	PriceFrom $1,179	Free Cancellation	Rating 7.1 11,989 reviews	Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to South America. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to South America with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to South America from Des Moines with this policy.

How can momondo help me find flights from Des Moines to South America?

momondo helps you find the best flight between Des Moines and South America by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to South America right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to South America flights. All you need is a valid email address and we will do the rest; it is that quick and easy.