What is the cheapest airline that flies from Des Moines to South America?

Delta, American Airlines, and United Airlines are the most popular carriers operating from Des Moines to South America

When did momondo last update prices for flights from Des Moines Airport to South America?

Prices for flights from Des Moines Airport to South America were last updated today.

How many operators does momondo search for flights from Des Moines Airport to South America?

As of April 2026, there are 4 operators available to choose from for flights from Des Moines Airport to South America.

How old do you have to be to fly from Des Moines Airport to South America?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to South America.

What documentation or ID do you need to fly to South America?

The travel and health documents you'll need for your trip to South America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$217 Cheap Flights from Des Moines to South America in 2026

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Find the cheapest flights from Des Moines to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

7:45 am - 12:26 pm

DSM

CTG

28h 41m

1 stop

1:31 pm - 9:09 pm

CTG

DSM

31h 38m

2 stops

$523Multiple Airlines

Thu, May 14 - Thu, May 21

8:03 pm - 2:04 pm

DSM

CTG

18h 01m

2 stops

3:15 pm - 9:11 am

CTG

DSM

17h 56m

2 stops

$615American Airlines

Sat, May 16 - Sat, May 23

6:30 pm - 9:10 pm

DSM

BAQ

26h 40m

3 stops

7:20 am - 10:26 pm

BAQ

DSM

15h 06m

3 stops

$628LATAM Airlines

Thu, Sep 17 - Thu, Sep 24

6:30 pm - 9:10 pm

DSM

BAQ

26h 40m

3 stops

7:20 am - 10:26 pm

BAQ

DSM

15h 06m

3 stops

$646LATAM Airlines

Thu, Sep 17 - Thu, Sep 24

10:56 am - 4:43 am

DSM

UIO

17h 47m

2 stops

12:59 am - 11:08 am

UIO

DSM

10h 09m

1 stop

$666Delta

Wed, May 27 - Wed, Jun 3

5:27 am - 12:58 pm

DSM

CTG

7h 31m

1 stop

2:13 pm - 10:32 pm

CTG

DSM

8h 19m

1 stop

$739Delta

Thu, May 14 - Thu, May 21

3:20 pm - 2:04 pm

DSM

CTG

22h 44m

2 stops

1:35 pm - 11:40 pm

CTG

DSM

10h 05m

1 stop

$743British Airways

Sat, May 16 - Sat, May 23

6:00 am - 5:29 pm

DSM

GYE

35h 29m

3 stops

12:21 pm - 10:35 pm

GYE

DSM

34h 14m

2 stops

$1,134United Airlines

Tue, Jun 16 - Sun, Jun 21

6:00 am - 8:51 pm

DSM

GYE

38h 51m

3 stops

12:21 pm - 10:35 pm

GYE

DSM

34h 14m

2 stops

$1,137United Airlines

Sun, Jun 14 - Sun, Jun 21

11:11 am - 10:00 am

DSM

CGB

21h 49m

3 stops

5:50 pm - 6:17 pm

CGB

DSM

25h 27m

3 stops

$1,934British Airways

Fri, May 15 - Fri, May 22

American Airlines flights from Des Moines to South America

Our best American Airlines deals on Des Moines to South America flight tickets

American Airlines

May 16

DSM8:03 pmDes Moines

18h 01m

2 stops

CTG2:04 pmCartagena Rafael Nunez

May 23

CTG3:15 pmCartagena Rafael Nunez

17h 56m

2 stops

DSM9:11 amDes Moines

$615

American Airlines

Sep 17

DSM6:34 pmDes Moines

17h 21m

2 stops

BAQ11:55 amBarranquilla E Cortissoz

Sep 24

BAQ2:15 pmBarranquilla E Cortissoz

24h 58m

2 stops

DSM3:13 pmDes Moines

$621

American Airlines

May 16

DSM1:50 pmDes Moines

22h 19m

2 stops

CTG12:09 pmCartagena Rafael Nunez

May 23

CTG1:35 pmCartagena Rafael Nunez

10h 05m

1 stop

DSM11:40 pmDes Moines

$627

Delta flights from Des Moines to South America

Our best Delta deals on Des Moines to South America flight tickets

Delta

May 27

DSM11:57 amDes Moines

16h 46m

2 stops

UIO4:43 amQuito Mariscal Sucr

Jun 4

UIO6:50 pmQuito Mariscal Sucr

23h 03m

2 stops

DSM5:53 pmDes Moines

$666

Delta

May 14

DSM5:27 amDes Moines

7h 31m

1 stop

CTG12:58 pmCartagena Rafael Nunez

May 21

CTG2:13 pmCartagena Rafael Nunez

8h 19m

1 stop

DSM10:32 pmDes Moines

$739

Delta

May 16

DSM5:56 pmDes Moines

25h 03m

2 stops

UIO6:59 pmQuito Mariscal Sucr

May 22

UIO12:59 amQuito Mariscal Sucr

19h 37m

2 stops

DSM8:36 pmDes Moines

$748

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Thu 5/14

7:45 am-12:26 pm

1 stop28h 41m

Cartagena Rafael Nunez

Thu 5/21

1:31 pm-9:09 pm

2 stops31h 38m

$523

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Sat 5/16

8:03 pm-2:04 pm

2 stops18h 01m

Cartagena Rafael Nunez

Sat 5/23

3:15 pm-9:11 am

2 stops17h 56m

$615

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Thu 9/17

6:30 pm-9:10 pm

3 stops26h 40m

Barranquilla E Cortissoz

Thu 9/24

7:20 am-10:26 pm

3 stops15h 06m

$628

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Thu 9/17

6:30 pm-9:10 pm

3 stops26h 40m

Barranquilla E Cortissoz

Thu 9/24

7:20 am-10:26 pm

3 stops15h 06m

$646

Des MoinesQuito

DSM - UIO

DSMUIO

Des Moines

Wed 5/27

10:56 am-4:43 am

2 stops17h 47m

Quito Mariscal Sucr

Wed 6/3

12:59 am-11:08 am

1 stop10h 09m

$666

Quickest round-trip

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Thu 5/14

5:27 am-12:58 pm

1 stop7h 31m

Cartagena Rafael Nunez

Thu 5/21

2:13 pm-10:32 pm

1 stop8h 19m

$739

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Sat 5/16

3:20 pm-2:04 pm

2 stops22h 44m

Cartagena Rafael Nunez

Sat 5/23

1:35 pm-11:40 pm

1 stop10h 05m

$743

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Tue 6/16

6:00 am-5:29 pm

3 stops35h 29m

Guayaquil Jose Joaquin de Olmedo

Sun 6/21

12:21 pm-10:35 pm

2 stops34h 14m

$1,134

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sun 6/14

6:00 am-8:51 pm

3 stops38h 51m

Guayaquil Jose Joaquin de Olmedo

Sun 6/21

12:21 pm-10:35 pm

2 stops34h 14m

$1,137

Des MoinesCuiabá

DSM - CGB

DSMCGB

Des Moines

Fri 5/15

11:11 am-10:00 am

3 stops21h 49m

Cuiabá M. Rondon

Fri 5/22

5:50 pm-6:17 pm

3 stops25h 27m

$1,934

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Can stopping save me money on Des Moines to South America flights?

You could potentially save up to 9% on your flight if you consider stops on a Des Moines to South America flight.

Cheap Des Moines to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to South America

Fastest flight time	13h 14m
Direct flights	None

The fastest flight from Des Moines to South America takes 13h 14m

There are no direct flights from Des Moines to South America. There are no popular flight routes from Des Moines to South America.

Search flight deals

Frequently asked questions about flying from Des Moines to South America

When did momondo last update prices for flights from Des Moines Airport to South America?
Prices for flights from Des Moines Airport to South America were last updated today.
How many operators does momondo search for flights from Des Moines Airport to South America?
As of April 2026, there are 4 operators available to choose from for flights from Des Moines Airport to South America.
How old do you have to be to fly from Des Moines Airport to South America?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to South America.
What documentation or ID do you need to fly to South America?
The travel and health documents you'll need for your trip to South America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to South America

Compare and see reviews for airlines that fly from Des Moines to South America with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $607	Free Cancellation	Rating 7.9 8,385 reviews		Search Delta flights
LATAM Airlines	PriceFrom $814	Free Cancellation	Rating 7.4 1,908 reviews		Search LATAM Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to South America. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to South America with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to South America from Des Moines with this policy.

How can momondo help me find flights from Des Moines to South America?

momondo helps you find the best flight between Des Moines and South America by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to South America right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to South America flights. All you need is a valid email address and we will do the rest; it is that quick and easy.