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Cheap flights from Des Moines to South America from $222

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to South America departing on 10/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to South America

Cheap round-trip flights

Logo
10:41 am - 1:25 pmDSM-CTG
25h 44m1 stop
Logo
2:16 pm - 5:08 pmCTG-DSM
27h 52m2 stops
$427
Find Deal
dom., nov. 2 - jue., nov. 6
Logo
3:17 pm - 1:10 pmDSM-BAQ
21h 53m2 stops
Logo
2:45 pm - 10:01 amBAQ-DSM
19h 16m1 stop
$434
Find Deal
mié., oct. 1 - mié., oct. 8
United Airlines Logo
6:15 am - 8:42 amDSM-CTG
26h 27m2 stops
United Airlines Logo
9:43 am - 10:20 pmCTG-DSM
36h 37m2 stops
$573United Airlines
Find Deal
dom., oct. 19 - dom., oct. 26
LATAM Airlines Logo
5:47 am - 1:14 pmDSM-CTG
7h 27m1 stop
LATAM Airlines Logo
3:08 pm - 10:30 pmCTG-DSM
8h 22m1 stop
$600LATAM Airlines
Find Deal
sáb., nov. 1 - jue., nov. 6
Delta Logo
5:47 am - 1:14 pmDSM-CTG
7h 27m1 stop
Delta Logo
4:35 am - 10:05 amCTG-DSM
30h 30m2 stops
$603Delta
Find Deal
sáb., nov. 1 - mié., nov. 5
American Airlines Logo
3:56 pm - 12:25 pmDSM-CTG
20h 29m2 stops
American Airlines Logo
1:25 pm - 11:40 amCTG-DSM
22h 15m2 stops
$604American Airlines
Find Deal
lun., oct. 27 - sáb., nov. 1
Delta Logo
5:47 am - 11:06 pmDSM-CTG
17h 19m2 stops
Delta Logo
2:30 pm - 10:30 pmCTG-DSM
8h 00m1 stop
$606Delta
Find Deal
lun., oct. 27 - sáb., nov. 1
American Airlines Logo
6:22 pm - 12:25 pmDSM-CTG
18h 03m2 stops
American Airlines Logo
1:25 pm - 9:00 amCTG-DSM
19h 35m2 stops
$615American Airlines
Find Deal
vie., oct. 17 - vie., oct. 24
United Airlines Logo
6:15 am - 8:42 amDSM-CTG
26h 27m2 stops
United Airlines Logo
9:43 am - 10:20 pmCTG-DSM
36h 37m2 stops
$618United Airlines
Find Deal
dom., oct. 19 - dom., oct. 26
LATAM Airlines Logo
10:50 am - 7:46 amDSM-CTG
19h 56m2 stops
LATAM Airlines Logo
4:35 am - 10:05 amCTG-DSM
30h 30m2 stops
$718LATAM Airlines
Find Deal
lun., nov. 3 - mié., nov. 5

LATAM Airlines flights from Des Moines to South America

Our best LATAM Airlines deals on Des Moines to South America flight tickets
LATAM Airlines
Nov 1
DSM5:47 amDes Moines
7h 27m
1 stop
CTG1:14 pmCartagena Rafael Nunez
Nov 6
CTG3:08 pmCartagena Rafael Nunez
8h 22m
1 stop
DSM10:30 pmDes Moines
$600
Find similar
LATAM Airlines
Nov 3
DSM10:50 amDes Moines
19h 56m
2 stops
CTG7:46 amCartagena Rafael Nunez
Nov 5
CTG4:35 amCartagena Rafael Nunez
30h 30m
2 stops
DSM10:05 amDes Moines
$718
Find similar
LATAM Airlines
Nov 2
DSM5:47 amDes Moines
20h 19m
2 stops
CTG3:06 amCartagena Rafael Nunez
Nov 5
CTG4:35 amCartagena Rafael Nunez
30h 30m
2 stops
DSM10:05 amDes Moines
$730
Find similar

Air Canada flights from Des Moines to South America

Our best Air Canada deals on Des Moines to South America flight tickets
Air Canada
Sep 14
DSM8:00 amDes Moines
23h 40m
2 stops
GRU9:40 amSao Paulo Guarulhos Intl
Sep 28
GRU9:40 pmSao Paulo Guarulhos Intl
26h 10m
2 stops
DSM9:50 pmDes Moines
$1,529
Find similar
Air Canada
Sep 14
DSM8:00 amDes Moines
23h 40m
2 stops
GRU9:40 amSao Paulo Guarulhos Intl
Sep 28
GRU9:40 pmSao Paulo Guarulhos Intl
26h 10m
2 stops
DSM9:50 pmDes Moines
$1,550
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated septiembre 4, 2025.
Use the filters below to find and compare flights from Des Moines to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

dom. 11/2

10:41 am-1:25 pm

1 stop25h 44m

Cartagena Rafael Nunez

jue. 11/6

2:16 pm-5:08 pm

2 stops27h 52m

$427

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

mié. 10/1

3:17 pm-1:10 pm

2 stops21h 53m

Barranquilla E Cortissoz

mié. 10/8

2:45 pm-10:01 am

1 stop19h 16m

$434

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

dom. 10/19

6:15 am-8:42 am

2 stops26h 27m

Cartagena Rafael Nunez

dom. 10/26

9:43 am-10:20 pm

2 stops36h 37m

$573

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

sáb. 11/1

5:47 am-1:14 pm

1 stop7h 27m

Cartagena Rafael Nunez

jue. 11/6

3:08 pm-10:30 pm

1 stop8h 22m

$600

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

sáb. 11/1

5:47 am-1:14 pm

1 stop7h 27m

Cartagena Rafael Nunez

mié. 11/5

4:35 am-10:05 am

2 stops30h 30m

$603

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

lun. 10/27

3:56 pm-12:25 pm

2 stops20h 29m

Cartagena Rafael Nunez

sáb. 11/1

1:25 pm-11:40 am

2 stops22h 15m

$604

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

lun. 10/27

5:47 am-11:06 pm

2 stops17h 19m

Cartagena Rafael Nunez

sáb. 11/1

2:30 pm-10:30 pm

1 stop8h 00m

$606

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

vie. 10/17

6:22 pm-12:25 pm

2 stops18h 03m

Cartagena Rafael Nunez

vie. 10/24

1:25 pm-9:00 am

2 stops19h 35m

$615

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

dom. 10/19

6:15 am-8:42 am

2 stops26h 27m

Cartagena Rafael Nunez

dom. 10/26

9:43 am-10:20 pm

2 stops36h 37m

$618

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

lun. 11/3

10:50 am-7:46 am

2 stops19h 56m

Cartagena Rafael Nunez

mié. 11/5

4:35 am-10:05 am

2 stops30h 30m

$718

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Des Moines to South America is on a Tuesday when prices can be found for as low as $666. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to South America for around $1,143.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest Des Moines to South America flights are usually those with departure times at noon. Our users have found flights to South America at noon for as low as $645. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $1,128 on average. Flights to South America from Des Moines in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Can stopping save me money on Des Moines to South America flights?

You could potentially save up to 12% on your flight if you consider stops on a Des Moines to South America flight.

Cheap Des Moines to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to South America

Direct flights

None
There are no direct flights from Des Moines to South America. There are no popular flight routes from Des Moines to South America.
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to South America?

    Prices for flights from Des Moines Airport to South America were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to South America?

  • How old do you have to be to fly from Des Moines Airport to South America?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The travel and health documents you'll need for your trip to South America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to South America

Compare and see reviews for airlines that fly from Des Moines to South America with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $488Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $503Free CancellationRating
7.9
7,977 reviews
Search Delta flights
United AirlinesPriceFrom $585Free CancellationRating
7.4
8,937 reviews
Search United Airlines flights
LATAM AirlinesPriceFrom $631Free CancellationRating
7.5
1,846 reviews
Search LATAM Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to South America. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to South America with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to South America from Des Moines with this policy.

How can momondo help me find flights from Des Moines to South America?

momondo helps you find the best flight between Des Moines and South America by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to South America right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to South America flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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