What airlines fly to South America?

LATAM Airlines, Delta and American Airlines are the top three most popular airlines that fly to South America from Des Moines according to our data. LATAM Airlines is the first choice among our users, with 48% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 3 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Des Moines to South America?

American Airlines, United Airlines, and Frontier are the most popular carriers operating from Des Moines to South America

When did momondo last update prices for flights from Des Moines Airport to South America?

Prices for flights from Des Moines Airport to South America were last updated today.

How many operators does momondo search for flights from Des Moines Airport to South America?

As of October 2026, there are 3 operators available to choose from for flights from Des Moines Airport to South America.

How old do you have to be to fly from Des Moines Airport to South America?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to South America.

What documentation or ID do you need to fly to South America?

The travel and health documents you'll need for your trip to South America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$380 Cheap Flights from Des Moines to South America in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

3:31 pm - 1:36 pmDSM Des Moines-CTG Cartagena Rafael Nunez

21h 05m2 stops Dallas/Fort Worth Miami

4:37 pm - 8:52 amCTG Cartagena Rafael Nunez-DSM Des Moines

17h 15m2 stops Miami Chicago O'Hare Intl

$557American Airlines

Sat, Dec 5 - Sat, Dec 12

1:02 pm - 1:10 pmDSM Des Moines-CTG Cartagena Rafael Nunez

23h 08m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

4:00 pm - 8:40 pmCTG Cartagena Rafael Nunez-DSM Des Moines

29h 40m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$700United Airlines

Mon, Feb 22 - Thu, Feb 25

3:00 pm - 2:50 pmDSM Des Moines-CTG Cartagena Rafael Nunez

22h 50m1 stop Houston George Bush Intcntl

4:00 pm - 8:40 pmCTG Cartagena Rafael Nunez-DSM Des Moines

29h 40m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$711United Airlines

Mon, Feb 22 - Thu, Feb 25

6:32 pm - 3:37 pmDSM Des Moines-CTG Cartagena Rafael Nunez

20h 05m2 stops Dallas/Fort Worth Miami

2:36 pm - 11:59 pmCTG Cartagena Rafael Nunez-DSM Des Moines

10h 23m1 stop Miami

$715American Airlines

Sat, Dec 5 - Sat, Dec 12

3:31 pm - 1:36 pmDSM Des Moines-CTG Cartagena Rafael Nunez

21h 05m2 stops Dallas/Fort Worth Miami

2:36 pm - 11:59 pmCTG Cartagena Rafael Nunez-DSM Des Moines

10h 23m1 stop Miami

$731American Airlines

Thu, Dec 3 - Thu, Dec 10

1:05 pm - 2:50 pmDSM Des Moines-CTG Cartagena Rafael Nunez

24h 45m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

4:00 pm - 12:30 pmCTG Cartagena Rafael Nunez-DSM Des Moines

21h 30m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$783United Airlines

Mon, Feb 22 - Thu, Feb 25

7:55 pm - 9:25 pmDSM Des Moines-UIO Quito Mariscal Sucr

24h 30m2 stops Minneapolis St Paul Atlanta Hartsfield-Jackson

12:55 am - 3:21 pmUIO Quito Mariscal Sucr-DSM Des Moines

15h 26m1 stop Atlanta Hartsfield-Jackson

$948Delta

Fri, Nov 20 - Thu, Nov 26

11:04 am - 11:00 pmDSM Des Moines-UIO Quito Mariscal Sucr

11h 56m2 stops Atlanta Hartsfield-Jackson Bogotá El Dorado

7:05 am - 10:18 amUIO Quito Mariscal Sucr-DSM Des Moines

27h 13m2 stops Bogotá El Dorado Atlanta Hartsfield-Jackson

$948LATAM Airlines

Tue, Apr 20 - Fri, Apr 23

11:04 am - 11:00 pmDSM Des Moines-UIO Quito Mariscal Sucr

11h 56m2 stops Atlanta Hartsfield-Jackson Bogotá El Dorado

12:59 am - 5:42 pmUIO Quito Mariscal Sucr-DSM Des Moines

16h 43m1 stop Atlanta Hartsfield-Jackson

$948LATAM Airlines

Tue, Apr 20 - Thu, Apr 22

11:04 am - 9:15 pmDSM Des Moines-LIM Lima J Chavez Intl

10h 11m1 stop Atlanta Hartsfield-Jackson

11:25 pm - 10:18 amLIM Lima J Chavez Intl-DSM Des Moines

10h 53m1 stop Atlanta Hartsfield-Jackson

$966Delta

Wed, Apr 14 - Tue, Apr 27

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Delta flights from Des Moines to South America

Our best Delta deals on Des Moines to South America flight tickets

Delta

Dec 3

DSM5:20 amDes Moines

16h 10m

2 stops

LIM10:30 pmLima J Chavez Intl

Dec 9

LIM12:15 amLima J Chavez Intl

21h 24m

2 stops

DSM8:39 pmDes Moines

$970

Delta

Jan 3

DSM6:43 pmDes Moines

25h 42m

1 stop

UIO9:25 pmQuito Mariscal Sucr

Jan 16

UIO8:55 amQuito Mariscal Sucr

27h 34m

2 stops

DSM11:29 amDes Moines

$1,027

Delta

Jan 3

DSM6:11 pmDes Moines

26h 14m

2 stops

UIO9:25 pmQuito Mariscal Sucr

Jan 16

UIO8:55 amQuito Mariscal Sucr

27h 34m

2 stops

DSM11:29 amDes Moines

$1,032

United Airlines flights from Des Moines to South America

Our best United Airlines deals on Des Moines to South America flight tickets

United Airlines

Feb 22

DSM1:02 pmDes Moines

23h 08m

2 stops

CTG1:10 pmCartagena Rafael Nunez

Feb 25

CTG4:00 pmCartagena Rafael Nunez

29h 40m

2 stops

DSM8:40 pmDes Moines

$700

United Airlines

Feb 22

DSM3:00 pmDes Moines

22h 50m

1 stop

CTG2:50 pmCartagena Rafael Nunez

Feb 25

CTG4:00 pmCartagena Rafael Nunez

29h 40m

2 stops

DSM8:40 pmDes Moines

$711

United Airlines

Feb 22

DSM1:05 pmDes Moines

24h 45m

2 stops

CTG2:50 pmCartagena Rafael Nunez

Feb 25

CTG4:00 pmCartagena Rafael Nunez

21h 30m

2 stops

DSM12:30 pmDes Moines

$783

momondo Fare Finder

Use the filters below to find and compare flights from Des Moines to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesCartagena

DSM Des Moines - CTG Cartagena Rafael Nunez

DSMCTG

Des Moines

Sat 12/5

3:31 pm-1:36 pm

2 stops21h 05m

Cartagena Rafael Nunez

Sat 12/12

4:37 pm-8:52 am

2 stops17h 15m

$557

Des MoinesCartagena

DSM Des Moines - CTG Cartagena Rafael Nunez

DSMCTG

Des Moines

Mon 2/22

1:02 pm-1:10 pm

2 stops23h 08m

Cartagena Rafael Nunez

Thu 2/25

4:00 pm-8:40 pm

2 stops29h 40m

$700

Des MoinesCartagena

DSM Des Moines - CTG Cartagena Rafael Nunez

DSMCTG

Des Moines

Mon 2/22

3:00 pm-2:50 pm

1 stop22h 50m

Cartagena Rafael Nunez

Thu 2/25

4:00 pm-8:40 pm

2 stops29h 40m

$711

Des MoinesCartagena

DSM Des Moines - CTG Cartagena Rafael Nunez

DSMCTG

Des Moines

Sat 12/5

6:32 pm-3:37 pm

2 stops20h 05m

Cartagena Rafael Nunez

Sat 12/12

2:36 pm-11:59 pm

1 stop10h 23m

$715

Des MoinesCartagena

DSM Des Moines - CTG Cartagena Rafael Nunez

DSMCTG

Des Moines

Thu 12/3

3:31 pm-1:36 pm

2 stops21h 05m

Cartagena Rafael Nunez

Thu 12/10

2:36 pm-11:59 pm

1 stop10h 23m

$731

Des MoinesCartagena

DSM Des Moines - CTG Cartagena Rafael Nunez

DSMCTG

Des Moines

Mon 2/22

1:05 pm-2:50 pm

2 stops24h 45m

Cartagena Rafael Nunez

Thu 2/25

4:00 pm-12:30 pm

2 stops21h 30m

$783

Des MoinesQuito

DSM Des Moines - UIO Quito Mariscal Sucr

DSMUIO

Des Moines

Fri 11/20

7:55 pm-9:25 pm

2 stops24h 30m

Quito Mariscal Sucr

Thu 11/26

12:55 am-3:21 pm

1 stop15h 26m

$948

Des MoinesQuito

DSM Des Moines - UIO Quito Mariscal Sucr

DSMUIO

Des Moines

Tue 4/20

11:04 am-11:00 pm

2 stops11h 56m

Quito Mariscal Sucr

Fri 4/23

7:05 am-10:18 am

2 stops27h 13m

$948

Des MoinesQuito

DSM Des Moines - UIO Quito Mariscal Sucr

DSMUIO

Des Moines

Tue 4/20

11:04 am-11:00 pm

2 stops11h 56m

Quito Mariscal Sucr

Thu 4/22

12:59 am-5:42 pm

1 stop16h 43m

$948

Quickest round-trip

Des MoinesLima

DSM Des Moines - LIM Lima J Chavez Intl

DSMLIM

Des Moines

Wed 4/14

11:04 am-9:15 pm

1 stop10h 11m

Lima J Chavez Intl

Tue 4/27

11:25 pm-10:18 am

1 stop10h 53m

$966

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from Des Moines to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $643. If you aren’t able to travel during the month of February, then book flights to South America from Des Moines during September instead. Flights to South America in September, while not as cheap as those in February, still average around $725.

Can stopping save me money on Des Moines to South America flights?

You could potentially save up to 8% on your flight if you consider stops on a Des Moines to South America flight.

Cheap Des Moines to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to South America

Best Price Found	$380
Fastest flight time	10h 45m
Direct flights	None

The best one-way flight to South America from Des Moines in the past 72 hours is $380. The best round-trip flight deal from Des Moines to South America found on momondo in the last 72 hours is $557.

The fastest flight from Des Moines to South America takes 10h 45m

There are no direct flights from Des Moines to South America. There are no popular flight routes from Des Moines to South America.

Search flight deals

Frequently asked questions about flying from Des Moines to South America

When did momondo last update prices for flights from Des Moines Airport to South America?
Prices for flights from Des Moines Airport to South America were last updated today.
How many operators does momondo search for flights from Des Moines Airport to South America?
As of October 2026, there are 3 operators available to choose from for flights from Des Moines Airport to South America.
How old do you have to be to fly from Des Moines Airport to South America?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to South America.
What documentation or ID do you need to fly to South America?
The travel and health documents you'll need for your trip to South America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to South America

Compare and see reviews for airlines that fly from Des Moines to South America with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $607	Free Cancellation	Rating 7.8 8,668 reviews	Search Delta flights
LATAM Airlines	PriceFrom $725	Free Cancellation	Rating 7.4 1,971 reviews	Search LATAM Airlines flights
American Airlines	PriceFrom $1,179	Free Cancellation	Rating 7.0 12,190 reviews	Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to South America. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to South America with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to South America from Des Moines with this policy.

How can momondo help me find flights from Des Moines to South America?

momondo helps you find the best flight between Des Moines and South America by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to South America right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to South America flights. All you need is a valid email address and we will do the rest; it is that quick and easy.