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Cheap flights from Des Moines to South America from $261

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to South America departing on 1/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to South America

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:58 pm - 2:41 pmDSM-BAQ
22h 43m1 stop
Multiple Airlines Logo
3:36 pm - 2:42 pmBAQ-DSM
24h 06m2 stops
$514Multiple Airlines
Find Deal
Sun, Feb 8 - Wed, Feb 11
Multiple Airlines Logo
4:30 pm - 2:41 pmDSM-BAQ
21h 11m2 stops
Multiple Airlines Logo
9:44 pm - 11:12 pmBAQ-DSM
26h 28m3 stops
$553Multiple Airlines
Find Deal
Sun, Feb 8 - Wed, Feb 11
American Airlines Logo
4:00 pm - 1:33 pmDSM-BAQ
20h 33m2 stops
American Airlines Logo
2:33 pm - 3:15 pmBAQ-DSM
25h 42m2 stops
$578American Airlines
Find Deal
Thu, Jan 15 - Thu, Jan 22
American Airlines Logo
4:00 pm - 1:33 pmDSM-BAQ
20h 33m2 stops
American Airlines Logo
2:33 pm - 11:29 pmBAQ-DSM
9h 56m1 stop
$602American Airlines
Find Deal
Thu, Jan 15 - Thu, Jan 22
United Airlines Logo
7:15 am - 11:36 pmDSM-BAQ
16h 21m2 stops
United Airlines Logo
9:08 am - 10:36 pmBAQ-DSM
13h 28m2 stops
$618United Airlines
Find Deal
Mon, Mar 9 - Fri, Mar 13
United Airlines Logo
7:15 am - 11:00 pmDSM-CTG
15h 45m2 stops
United Airlines Logo
3:02 pm - 10:36 pmCTG-DSM
31h 34m2 stops
$619United Airlines
Find Deal
Sun, Mar 8 - Thu, Mar 12
Delta Logo
5:45 am - 1:15 pmDSM-CTG
7h 30m1 stop
Delta Logo
5:05 am - 10:23 amCTG-DSM
29h 18m2 stops
$651Delta
Find Deal
Sun, Mar 8 - Thu, Mar 12
Delta Logo
5:15 pm - 1:15 pmDSM-CTG
20h 00m1 stop
Delta Logo
10:12 am - 10:23 amCTG-DSM
24h 11m2 stops
$652Delta
Find Deal
Sun, Mar 8 - Thu, Mar 12
LATAM Airlines Logo
5:16 pm - 9:35 pmDSM-UIO
27h 19m1 stop
LATAM Airlines Logo
11:45 pm - 10:41 amUIO-DSM
11h 56m1 stop
$712LATAM Airlines
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Wed, Jan 14 - Wed, Jan 28
LATAM Airlines Logo
11:04 am - 9:20 amDSM-LIM
22h 16m2 stops
LATAM Airlines Logo
8:50 am - 10:23 amLIM-DSM
25h 33m2 stops
$723LATAM Airlines
Find Deal
Mon, Mar 16 - Fri, Mar 20

LATAM Airlines flights from Des Moines to South America

Our best LATAM Airlines deals on Des Moines to South America flight tickets
LATAM Airlines
Jan 14
DSM5:16 pmDes Moines
27h 19m
1 stop
UIO9:35 pmQuito Mariscal Sucr
Jan 28
UIO11:45 pmQuito Mariscal Sucr
11h 56m
1 stop
DSM10:41 amDes Moines
$712
Find similar
LATAM Airlines
Mar 16
DSM11:04 amDes Moines
22h 16m
2 stops
LIM9:20 amLima J Chavez Intl
Mar 20
LIM8:50 amLima J Chavez Intl
25h 33m
2 stops
DSM10:23 amDes Moines
$723
Find similar
LATAM Airlines
Mar 16
DSM5:15 pmDes Moines
27h 40m
1 stop
LIM8:55 pmLima J Chavez Intl
Mar 20
LIM10:50 amLima J Chavez Intl
23h 33m
2 stops
DSM10:23 amDes Moines
$748
Find similar

Delta flights from Des Moines to South America

Our best Delta deals on Des Moines to South America flight tickets
Delta
Mar 8
DSM5:45 amDes Moines
7h 30m
1 stop
CTG1:15 pmCartagena Rafael Nunez
Mar 12
CTG5:05 amCartagena Rafael Nunez
29h 18m
2 stops
DSM10:23 amDes Moines
$651
Find similar
Delta
Mar 8
DSM5:15 pmDes Moines
20h 00m
1 stop
CTG1:15 pmCartagena Rafael Nunez
Mar 12
CTG10:12 amCartagena Rafael Nunez
24h 11m
2 stops
DSM10:23 amDes Moines
$652
Find similar
Delta
Mar 8
DSM5:45 amDes Moines
7h 30m
1 stop
CTG1:15 pmCartagena Rafael Nunez
Mar 12
CTG2:30 pmCartagena Rafael Nunez
19h 53m
1 stop
DSM10:23 amDes Moines
$659
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Des Moines to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Sun 2/8

2:58 pm-2:41 pm

1 stop22h 43m

Barranquilla E Cortissoz

Wed 2/11

3:36 pm-2:42 pm

2 stops24h 06m

$514

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Sun 2/8

4:30 pm-2:41 pm

2 stops21h 11m

Barranquilla E Cortissoz

Wed 2/11

9:44 pm-11:12 pm

3 stops26h 28m

$553

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Thu 1/15

4:00 pm-1:33 pm

2 stops20h 33m

Barranquilla E Cortissoz

Thu 1/22

2:33 pm-3:15 pm

2 stops25h 42m

$578

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Thu 1/15

4:00 pm-1:33 pm

2 stops20h 33m

Barranquilla E Cortissoz

Thu 1/22

2:33 pm-11:29 pm

1 stop9h 56m

$602

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Mon 3/9

7:15 am-11:36 pm

2 stops16h 21m

Barranquilla E Cortissoz

Fri 3/13

9:08 am-10:36 pm

2 stops13h 28m

$618

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Sun 3/8

7:15 am-11:00 pm

2 stops15h 45m

Cartagena Rafael Nunez

Thu 3/12

3:02 pm-10:36 pm

2 stops31h 34m

$619

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Sun 3/8

5:45 am-1:15 pm

1 stop7h 30m

Cartagena Rafael Nunez

Thu 3/12

5:05 am-10:23 am

2 stops29h 18m

$651

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Sun 3/8

5:15 pm-1:15 pm

1 stop20h 00m

Cartagena Rafael Nunez

Thu 3/12

10:12 am-10:23 am

2 stops24h 11m

$652

Des MoinesQuito

DSM - UIO

DSMUIO

Des Moines

Wed 1/14

5:16 pm-9:35 pm

1 stop27h 19m

Quito Mariscal Sucr

Wed 1/28

11:45 pm-10:41 am

1 stop11h 56m

$712

Des MoinesLima

DSM - LIM

DSMLIM

Des Moines

Mon 3/16

11:04 am-9:20 am

2 stops22h 16m

Lima J Chavez Intl

Fri 3/20

8:50 am-10:23 am

2 stops25h 33m

$723

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Des Moines to South America is on a Tuesday when prices can be found for as low as $666. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Des Moines to South America for around $1,143.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest Des Moines to South America flights are usually those with departure times at noon. Our users have found flights to South America at noon for as low as $645. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $1,128 on average. Flights to South America from Des Moines in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Can stopping save me money on Des Moines to South America flights?

You could potentially save up to 12% on your flight if you consider stops on a Des Moines to South America flight.

Cheap Des Moines to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to South America

Direct flights

None
There are no direct flights from Des Moines to South America. There are no popular flight routes from Des Moines to South America.
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to South America?

    Prices for flights from Des Moines Airport to South America were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to South America?

  • How old do you have to be to fly from Des Moines Airport to South America?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The travel and health documents you'll need for your trip to South America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Des Moines to South America

Compare and see reviews for airlines that fly from Des Moines to South America with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $566Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights
LATAM AirlinesPriceFrom $571Free CancellationRating
7.5
1,872 reviews
Search LATAM Airlines flights
United AirlinesPriceFrom $585Free CancellationRating
7.4
9,007 reviews
Search United Airlines flights
DeltaPriceFrom $709Free CancellationRating
7.9
8,001 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to South America. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to South America with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to South America from Des Moines with this policy.

How can momondo help me find flights from Des Moines to South America?

momondo helps you find the best flight between Des Moines and South America by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to South America right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to South America flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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Find better results for your trip to South America

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Popular flights according to clicks in the last 7 days on momondo
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