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Cheap flights from Des Moines to Santa Fe from $304

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Santa Fe departing on 9/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Santa Fe

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
5:21 pm - 8:36 pm
DSM
-
SAF
4h 15m
1 stop
United Airlines Logo
6:00 pm - 11:33 pm
SAF
-
DSM
4h 33m
1 stop
$304United Airlines
Sat, Sep 5 - Tue, Sep 8
American Airlines Logo
5:12 am - 9:41 am
DSM
-
SAF
5h 29m
1 stop
American Airlines Logo
5:23 pm - 11:58 pm
SAF
-
DSM
5h 35m
1 stop
$334American Airlines
Sat, Jul 4 - Wed, Jul 8
United Airlines Logo
5:50 am - 9:44 am
DSM
-
SAF
4h 54m
1 stop
United Airlines Logo
6:00 pm - 11:44 pm
SAF
-
DSM
4h 44m
1 stop
$364United Airlines
Thu, Jul 2 - Sun, Jul 5
United Airlines Logo
6:00 am - 9:32 am
DSM
-
SAF
4h 32m
1 stop
United Airlines Logo
1:20 pm - 8:32 pm
SAF
-
DSM
6h 12m
1 stop
$384United Airlines
Thu, Oct 29 - Tue, Nov 3
American Airlines Logo
4:48 pm - 10:04 pm
DSM
-
SAF
6h 16m
1 stop
American Airlines Logo
5:23 pm - 11:59 pm
SAF
-
DSM
5h 36m
1 stop
$407American Airlines
Sat, Jul 18 - Fri, Jul 24
United Airlines Logo
5:45 am - 9:46 am
DSM
-
SAF
5h 01m
1 stop
United Airlines Logo
10:30 am - 4:19 pm
SAF
-
DSM
4h 49m
1 stop
$425United Airlines
Sat, Aug 29 - Wed, Sep 2
American Airlines Logo
5:30 am - 9:38 am
DSM
-
SAF
5h 08m
1 stop
American Airlines Logo
6:51 am - 1:05 pm
SAF
-
DSM
5h 14m
1 stop
$430American Airlines
Wed, Jul 1 - Sun, Jul 5
United Airlines Logo
5:17 pm - 8:41 pm
DSM
-
SAF
4h 24m
1 stop
United Airlines Logo
6:00 pm - 11:44 pm
SAF
-
DSM
4h 44m
1 stop
$444United Airlines
Wed, Jul 1 - Sun, Jul 5
American Airlines Logo
5:37 am - 11:13 am
DSM
-
SAF
6h 36m
1 stop
American Airlines Logo
9:58 am - 4:41 pm
SAF
-
DSM
5h 43m
1 stop
$457American Airlines
Thu, Oct 29 - Tue, Nov 3
United Airlines Logo
3:02 pm - 9:46 am
DSM
-
SAF
19h 44m
2 stops
United Airlines Logo
6:00 pm - 11:33 pm
SAF
-
DSM
4h 33m
1 stop
$511United Airlines
Sat, Sep 5 - Tue, Sep 8

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American Airlines flights from Des Moines to Santa Fe

Our best American Airlines deals on Des Moines to Santa Fe flight tickets
American Airlines
Jul 4
DSM5:12 amDes Moines
5h 29m
1 stop
SAF9:41 amSanta Fe
Jul 8
SAF5:23 pmSanta Fe
5h 35m
1 stop
DSM11:58 pmDes Moines
$334
American Airlines
Jul 18
DSM4:48 pmDes Moines
6h 16m
1 stop
SAF10:04 pmSanta Fe
Jul 24
SAF5:23 pmSanta Fe
5h 36m
1 stop
DSM11:59 pmDes Moines
$407
American Airlines
Jul 1
DSM5:30 amDes Moines
5h 08m
1 stop
SAF9:38 amSanta Fe
Jul 5
SAF6:51 amSanta Fe
5h 14m
1 stop
DSM1:05 pmDes Moines
$430

United Airlines flights from Des Moines to Santa Fe

Our best United Airlines deals on Des Moines to Santa Fe flight tickets
United Airlines
Sep 5
DSM5:21 pmDes Moines
4h 15m
1 stop
SAF8:36 pmSanta Fe
Sep 8
SAF6:00 pmSanta Fe
4h 33m
1 stop
DSM11:33 pmDes Moines
$304
United Airlines
Jul 2
DSM5:50 amDes Moines
4h 54m
1 stop
SAF9:44 amSanta Fe
Jul 5
SAF6:00 pmSanta Fe
4h 44m
1 stop
DSM11:44 pmDes Moines
$364
United Airlines
Oct 29
DSM6:00 amDes Moines
4h 32m
1 stop
SAF9:32 amSanta Fe
Nov 3
SAF1:20 pmSanta Fe
6h 12m
1 stop
DSM8:32 pmDes Moines
$384

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 21, 2026.
Use the filters below to find and compare flights from Des Moines to Santa Fe that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 9/5

5:21 pm-8:36 pm

1 stop4h 15m

Santa Fe

Tue 9/8

6:00 pm-11:33 pm

1 stop4h 33m

$304

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 7/4

5:12 am-9:41 am

1 stop5h 29m

Santa Fe

Wed 7/8

5:23 pm-11:58 pm

1 stop5h 35m

$334

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Thu 7/2

5:50 am-9:44 am

1 stop4h 54m

Santa Fe

Sun 7/5

6:00 pm-11:44 pm

1 stop4h 44m

$364

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Thu 10/29

6:00 am-9:32 am

1 stop4h 32m

Santa Fe

Tue 11/3

1:20 pm-8:32 pm

1 stop6h 12m

$384

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 7/18

4:48 pm-10:04 pm

1 stop6h 16m

Santa Fe

Fri 7/24

5:23 pm-11:59 pm

1 stop5h 36m

$407

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 8/29

5:45 am-9:46 am

1 stop5h 01m

Santa Fe

Wed 9/2

10:30 am-4:19 pm

1 stop4h 49m

$425

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 7/1

5:30 am-9:38 am

1 stop5h 08m

Santa Fe

Sun 7/5

6:51 am-1:05 pm

1 stop5h 14m

$430

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 7/1

5:17 pm-8:41 pm

1 stop4h 24m

Santa Fe

Sun 7/5

6:00 pm-11:44 pm

1 stop4h 44m

$444

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Thu 10/29

5:37 am-11:13 am

1 stop6h 36m

Santa Fe

Tue 11/3

9:58 am-4:41 pm

1 stop5h 43m

$457

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 9/5

3:02 pm-9:46 am

2 stops19h 44m

Santa Fe

Tue 9/8

6:00 pm-11:33 pm

1 stop4h 33m

$511

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Santa Fe from

How to get the cheapest flight ticket from Des Moines to Santa Fe

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Santa Fe?

What is the cheapest month to fly to Santa Fe?

The month of January is, on average, the cheapest month to fly to Santa Fe from Des Moines, with most prices found around $0. If you’re not able to fly to Santa Fe in January, then October is your next best option. Flight prices from Des Moines to Santa Fe during October average around $324.

When to book flights from Des Moines to Santa Fe

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santa Fe according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santa Fe (DSM to SAF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santa Fe

Fastest flight time

4h 15m

Direct flights

None
The fastest flight from Des Moines to Santa Fe takes 4h 15m
There are no direct flights from Des Moines to Santa Fe. There are no popular flight routes from Des Moines to Santa Fe.
Search flight deals

Frequently asked questions about flying from Des Moines to Santa Fe

  • How far is Des Moines to Santa Fe by plane?

    There are 777.7 mi between Des Moines and Santa Fe. A reasonable flight in good conditions will take 4h 15m.

  • When did momondo last update prices for flights from Des Moines Airport to Santa Fe Airport?

    Prices for flights from Des Moines Airport to Santa Fe Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Santa Fe Airport?

  • How old do you have to be to fly from Des Moines Airport to Santa Fe Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santa Fe Airport.

  • What documentation or ID do you need to fly to Santa Fe Airport?

    The necessary travel and health documents for your Santa Fe Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Santa Fe?

Best airlines flying from Des Moines to Santa Fe

Compare and see reviews for airlines that fly from Des Moines to Santa Fe with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $244Free CancellationRating
7.1
11,722 reviews
Search American Airlines flights
United AirlinesPriceFrom $265Free CancellationRating
7.4
9,868 reviews
Search United Airlines flights

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Los Alamos
Santa Rosa

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santa Fe?

It is quick and easy to find Des Moines to Santa Fe flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santa Fe that suits you.

Can I find flights from Des Moines to Santa Fe with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Santa Fe flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Santa Fe?

momondo provides multiple filters to help you find the best flight to Santa Fe from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Santa Fe right now. Can momondo alert me if prices change?

Price alerts on flights to Santa Fe from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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