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Cheap flights from Des Moines to Santa Fe from $245

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Santa Fe departing on 1/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Santa Fe

Cheap round-trip flights

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American Airlines Logo
4:00 pm - 9:09 pmDSM-SAF
6h 09m1 stop
American Airlines Logo
10:28 am - 5:06 pmSAF-DSM
5h 38m1 stop
$245American Airlines
Find Deal
Wed, Jan 7 - Wed, Jan 14
United Airlines Logo
9:00 am - 12:37 pmDSM-SAF
4h 37m1 stop
United Airlines Logo
1:20 pm - 8:48 pmSAF-DSM
6h 28m1 stop
$274United Airlines
Find Deal
Tue, Dec 9 - Sat, Dec 13
American Airlines Logo
5:40 am - 2:55 pmDSM-SAF
10h 15m2 stops
American Airlines Logo
6:15 am - 2:51 pmSAF-DSM
7h 36m1 stop
$284American Airlines
Find Deal
Tue, Dec 9 - Sat, Dec 13
American Airlines Logo
4:00 pm - 9:09 pmDSM-SAF
6h 09m1 stop
American Airlines Logo
3:23 pm - 11:58 pmSAF-DSM
7h 35m1 stop
$289American Airlines
Find Deal
Wed, Feb 4 - Sun, Feb 8
United Airlines Logo
5:09 pm - 8:47 pmDSM-SAF
4h 38m1 stop
United Airlines Logo
6:05 pm - 11:44 pmSAF-DSM
4h 39m1 stop
$314United Airlines
Find Deal
Fri, Jan 9 - Fri, Jan 16
United Airlines Logo
9:00 am - 2:39 pmDSM-SAF
6h 39m1 stop
United Airlines Logo
7:00 am - 12:38 pmSAF-DSM
4h 38m1 stop
$344United Airlines
Find Deal
Wed, Dec 10 - Sun, Dec 14
American Airlines Logo
4:00 pm - 9:09 pmDSM-SAF
6h 09m1 stop
American Airlines Logo
12:14 pm - 11:23 pmSAF-DSM
10h 09m2 stops
$376American Airlines
Find Deal
Wed, Jan 7 - Wed, Jan 14
American Airlines Logo
4:00 pm - 9:09 pmDSM-SAF
6h 09m1 stop
American Airlines Logo
12:14 pm - 11:23 pmSAF-DSM
10h 09m2 stops
$445American Airlines
Find Deal
Wed, Jan 7 - Sat, Jan 10
American Airlines Logo
4:00 pm - 9:09 pmDSM-SAF
6h 09m1 stop
American Airlines Logo
12:14 pm - 11:23 pmSAF-DSM
10h 09m2 stops
$463American Airlines
Find Deal
Wed, Feb 4 - Sun, Feb 8
United Airlines Logo
6:48 pm - 4:56 pmDSM-SAF
23h 08m2 stops
United Airlines Logo
3:30 pm - 11:44 pmSAF-DSM
7h 14m1 stop
$490United Airlines
Find Deal
Fri, Jan 9 - Fri, Jan 16

United Airlines flights from Des Moines to Santa Fe

Our best United Airlines deals on Des Moines to Santa Fe flight tickets
United Airlines
Dec 9
DSM9:00 amDes Moines
4h 37m
1 stop
SAF12:37 pmSanta Fe
Dec 13
SAF1:20 pmSanta Fe
6h 28m
1 stop
DSM8:48 pmDes Moines
$274
Find similar
United Airlines
Jan 9
DSM5:09 pmDes Moines
4h 38m
1 stop
SAF8:47 pmSanta Fe
Jan 16
SAF6:05 pmSanta Fe
4h 39m
1 stop
DSM11:44 pmDes Moines
$314
Find similar
United Airlines
Dec 10
DSM9:00 amDes Moines
6h 39m
1 stop
SAF2:39 pmSanta Fe
Dec 14
SAF7:00 amSanta Fe
4h 38m
1 stop
DSM12:38 pmDes Moines
$344
Find similar

American Airlines flights from Des Moines to Santa Fe

Our best American Airlines deals on Des Moines to Santa Fe flight tickets
American Airlines
Jan 7
DSM4:00 pmDes Moines
6h 09m
1 stop
SAF9:09 pmSanta Fe
Jan 14
SAF10:28 amSanta Fe
5h 38m
1 stop
DSM5:06 pmDes Moines
$245
Find similar
American Airlines
Dec 9
DSM5:40 amDes Moines
10h 15m
2 stops
SAF2:55 pmSanta Fe
Dec 13
SAF6:15 amSanta Fe
7h 36m
1 stop
DSM2:51 pmDes Moines
$284
Find similar
American Airlines
Feb 4
DSM4:00 pmDes Moines
6h 09m
1 stop
SAF9:09 pmSanta Fe
Feb 8
SAF3:23 pmSanta Fe
7h 35m
1 stop
DSM11:58 pmDes Moines
$289
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 25, 2025.
Use the filters below to find and compare flights from Des Moines to Santa Fe that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 1/7

4:00 pm-9:09 pm

1 stop6h 09m

Santa Fe

Wed 1/14

10:28 am-5:06 pm

1 stop5h 38m

$245

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Tue 12/9

9:00 am-12:37 pm

1 stop4h 37m

Santa Fe

Sat 12/13

1:20 pm-8:48 pm

1 stop6h 28m

$274

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Tue 12/9

5:40 am-2:55 pm

2 stops10h 15m

Santa Fe

Sat 12/13

6:15 am-2:51 pm

1 stop7h 36m

$284

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 2/4

4:00 pm-9:09 pm

1 stop6h 09m

Santa Fe

Sun 2/8

3:23 pm-11:58 pm

1 stop7h 35m

$289

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Fri 1/9

5:09 pm-8:47 pm

1 stop4h 38m

Santa Fe

Fri 1/16

6:05 pm-11:44 pm

1 stop4h 39m

$314

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 12/10

9:00 am-2:39 pm

1 stop6h 39m

Santa Fe

Sun 12/14

7:00 am-12:38 pm

1 stop4h 38m

$344

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 1/7

4:00 pm-9:09 pm

1 stop6h 09m

Santa Fe

Wed 1/14

12:14 pm-11:23 pm

2 stops10h 09m

$376

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 1/7

4:00 pm-9:09 pm

1 stop6h 09m

Santa Fe

Sat 1/10

12:14 pm-11:23 pm

2 stops10h 09m

$445

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 2/4

4:00 pm-9:09 pm

1 stop6h 09m

Santa Fe

Sun 2/8

12:14 pm-11:23 pm

2 stops10h 09m

$463

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Fri 1/9

6:48 pm-4:56 pm

2 stops23h 08m

Santa Fe

Fri 1/16

3:30 pm-11:44 pm

1 stop7h 14m

$490

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Santa Fe from

How to get the cheapest flight ticket from Des Moines to Santa Fe

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Santa Fe?

What is the cheapest day to depart on your flight to Santa Fe?

According to our data, Friday is the cheapest day to fly to Santa Fe from Des Moines. The lowest ticket price found for a Friday departure recently was $301. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. Be sure to avoid booking your departure on a Thursday as prices are generally higher than usual. According to our data, the average ticket price to Santa Fe on Thursday is $510.

What is the cheapest time of day to depart on your flight to Santa Fe?

The cheapest time of day to fly to Santa Fe is at noon when flights can be purchased for as low as $333. Try not to purchase tickets in the morning because they tend to be around $440. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Des Moines to Santa Fe

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santa Fe according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santa Fe (DSM to SAF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santa Fe

Fastest flight time

4h 21m

Direct flights

None
The fastest flight from Des Moines to Santa Fe takes 4h 21m
There are no direct flights from Des Moines to Santa Fe. There are no popular flight routes from Des Moines to Santa Fe.
Search flight deals

  • How far is Des Moines to Santa Fe by plane?

    There are 777.7 mi between Des Moines and Santa Fe. A reasonable flight in good conditions will take 4h 37m.

  • When did momondo last update prices for flights from Des Moines Airport to Santa Fe Airport?

    Prices for flights from Des Moines Airport to Santa Fe Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Santa Fe Airport?

  • How old do you have to be to fly from Des Moines Airport to Santa Fe Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santa Fe Airport.

  • What documentation or ID do you need to fly to Santa Fe Airport?

    The necessary travel and health documents for your Santa Fe Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Santa Fe?

Best airlines flying from Des Moines to Santa Fe

Compare and see reviews for airlines that fly from Des Moines to Santa Fe with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $265Free CancellationRating
7.4
9,044 reviews
Search United Airlines flights

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa
Los Alamos

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santa Fe?

It is quick and easy to find Des Moines to Santa Fe flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santa Fe that suits you.

Can I find flights from Des Moines to Santa Fe with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Santa Fe flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Santa Fe?

momondo provides multiple filters to help you find the best flight to Santa Fe from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Santa Fe right now. Can momondo alert me if prices change?

Price alerts on flights to Santa Fe from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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