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Cheap flights from Des Moines to Santa Fe from $324

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Santa Fe departing on 5/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Santa Fe

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:00 am - 10:07 am
DSM
-
SAF
6h 07m
1 stop
American Airlines Logo
4:09 pm - 11:16 pm
SAF
-
DSM
6h 07m
1 stop
$324American Airlines
Thu, May 7 - Tue, May 12
American Airlines Logo
5:00 am - 10:07 am
DSM
-
SAF
6h 07m
1 stop
American Airlines Logo
11:56 am - 11:49 pm
SAF
-
DSM
10h 53m
2 stops
$334American Airlines
Thu, May 7 - Tue, May 12
United Airlines Logo
1:40 pm - 5:11 pm
DSM
-
SAF
4h 31m
1 stop
United Airlines Logo
7:00 am - 12:36 pm
SAF
-
DSM
4h 36m
1 stop
$404United Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
5:30 am - 9:09 am
DSM
-
SAF
4h 39m
1 stop
United Airlines Logo
3:24 pm - 8:34 pm
SAF
-
DSM
4h 10m
1 stop
$414United Airlines
Sat, Apr 4 - Wed, Apr 8
United Airlines Logo
5:50 am - 9:44 am
DSM
-
SAF
4h 54m
1 stop
United Airlines Logo
6:00 pm - 11:44 pm
SAF
-
DSM
4h 44m
1 stop
$559United Airlines
Wed, Jul 1 - Sun, Jul 5
American Airlines Logo
4:48 pm - 9:52 pm
DSM
-
SAF
6h 04m
1 stop
American Airlines Logo
7:30 am - 4:00 pm
SAF
-
DSM
7h 30m
1 stop
$563American Airlines
Wed, Jul 1 - Sun, Jul 5
American Airlines Logo
6:00 am - 5:56 pm
DSM
-
SAF
12h 56m
2 stops
American Airlines Logo
11:56 am - 11:16 pm
SAF
-
DSM
10h 20m
2 stops
$578American Airlines
Thu, May 7 - Tue, May 12
United Airlines Logo
3:21 pm - 9:09 am
DSM
-
SAF
18h 48m
2 stops
United Airlines Logo
5:49 pm - 11:42 pm
SAF
-
DSM
4h 53m
1 stop
$603United Airlines
Sat, Apr 11 - Wed, Apr 15
United Airlines Logo
11:25 am - 9:09 am
DSM
-
SAF
22h 44m
2 stops
United Airlines Logo
3:24 pm - 11:42 pm
SAF
-
DSM
7h 18m
1 stop
$623United Airlines
Sat, Apr 4 - Wed, Apr 8
United Airlines Logo
5:50 am - 9:46 am
DSM
-
SAF
4h 56m
1 stop
United Airlines Logo
7:00 am - 7:24 pm
SAF
-
DSM
11h 24m
2 stops
$707United Airlines
Sat, Aug 22 - Wed, Aug 26

American Airlines flights from Des Moines to Santa Fe

Our best American Airlines deals on Des Moines to Santa Fe flight tickets
American Airlines
May 7
DSM5:00 amDes Moines
6h 07m
1 stop
SAF10:07 amSanta Fe
May 12
SAF4:09 pmSanta Fe
6h 07m
1 stop
DSM11:16 pmDes Moines
$324
American Airlines
May 7
DSM5:00 amDes Moines
6h 07m
1 stop
SAF10:07 amSanta Fe
May 12
SAF11:56 amSanta Fe
10h 53m
2 stops
DSM11:49 pmDes Moines
$334
American Airlines
Jul 1
DSM4:48 pmDes Moines
6h 04m
1 stop
SAF9:52 pmSanta Fe
Jul 5
SAF7:30 amSanta Fe
7h 30m
1 stop
DSM4:00 pmDes Moines
$563

United Airlines flights from Des Moines to Santa Fe

Our best United Airlines deals on Des Moines to Santa Fe flight tickets
United Airlines
Aug 22
DSM1:40 pmDes Moines
4h 31m
1 stop
SAF5:11 pmSanta Fe
Aug 26
SAF7:00 amSanta Fe
4h 36m
1 stop
DSM12:36 pmDes Moines
$404
United Airlines
Apr 4
DSM5:30 amDes Moines
4h 39m
1 stop
SAF9:09 amSanta Fe
Apr 8
SAF3:24 pmSanta Fe
4h 10m
1 stop
DSM8:34 pmDes Moines
$414
United Airlines
Jul 1
DSM5:50 amDes Moines
4h 54m
1 stop
SAF9:44 amSanta Fe
Jul 5
SAF6:00 pmSanta Fe
4h 44m
1 stop
DSM11:44 pmDes Moines
$559

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Des Moines to Santa Fe that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Thu 5/7

5:00 am-10:07 am

1 stop6h 07m

Santa Fe

Tue 5/12

4:09 pm-11:16 pm

1 stop6h 07m

$324

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Thu 5/7

5:00 am-10:07 am

1 stop6h 07m

Santa Fe

Tue 5/12

11:56 am-11:49 pm

2 stops10h 53m

$334

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 8/22

1:40 pm-5:11 pm

1 stop4h 31m

Santa Fe

Wed 8/26

7:00 am-12:36 pm

1 stop4h 36m

$404
Quickest round-trip

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 4/4

5:30 am-9:09 am

1 stop4h 39m

Santa Fe

Wed 4/8

3:24 pm-8:34 pm

1 stop4h 10m

$414

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 7/1

5:50 am-9:44 am

1 stop4h 54m

Santa Fe

Sun 7/5

6:00 pm-11:44 pm

1 stop4h 44m

$559

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 7/1

4:48 pm-9:52 pm

1 stop6h 04m

Santa Fe

Sun 7/5

7:30 am-4:00 pm

1 stop7h 30m

$563

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Thu 5/7

6:00 am-5:56 pm

2 stops12h 56m

Santa Fe

Tue 5/12

11:56 am-11:16 pm

2 stops10h 20m

$578

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 4/11

3:21 pm-9:09 am

2 stops18h 48m

Santa Fe

Wed 4/15

5:49 pm-11:42 pm

1 stop4h 53m

$603

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 4/4

11:25 am-9:09 am

2 stops22h 44m

Santa Fe

Wed 4/8

3:24 pm-11:42 pm

1 stop7h 18m

$623

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 8/22

5:50 am-9:46 am

1 stop4h 56m

Santa Fe

Wed 8/26

7:00 am-7:24 pm

2 stops11h 24m

$707

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Santa Fe from

How to get the cheapest flight ticket from Des Moines to Santa Fe

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Santa Fe?

When to book flights from Des Moines to Santa Fe

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santa Fe according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santa Fe (DSM to SAF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santa Fe

Fastest flight time

4h 32m

Direct flights

None
The fastest flight from Des Moines to Santa Fe takes 4h 32m
There are no direct flights from Des Moines to Santa Fe. There are no popular flight routes from Des Moines to Santa Fe.
Search flight deals

  • How far is Des Moines to Santa Fe by plane?

    There are 777.7 mi between Des Moines and Santa Fe. A reasonable flight in good conditions will take 4h 32m.

  • When did momondo last update prices for flights from Des Moines Airport to Santa Fe Airport?

    Prices for flights from Des Moines Airport to Santa Fe Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Santa Fe Airport?

  • How old do you have to be to fly from Des Moines Airport to Santa Fe Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santa Fe Airport.

  • What documentation or ID do you need to fly to Santa Fe Airport?

    The necessary travel and health documents for your Santa Fe Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Santa Fe?

Best airlines flying from Des Moines to Santa Fe

Compare and see reviews for airlines that fly from Des Moines to Santa Fe with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $289Free CancellationRating
7.4
9,462 reviews
Search United Airlines flights

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Los Alamos
Santa Rosa

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santa Fe?

It is quick and easy to find Des Moines to Santa Fe flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santa Fe that suits you.

Can I find flights from Des Moines to Santa Fe with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Santa Fe flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Santa Fe?

momondo provides multiple filters to help you find the best flight to Santa Fe from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Santa Fe right now. Can momondo alert me if prices change?

Price alerts on flights to Santa Fe from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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