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Cheap flights from Des Moines to Santa Fe from $314

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Santa Fe departing on 9/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Santa Fe

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
11:33 am - 5:11 pmDSM  Des Moines-SAF Santa Fe
6h 38m1 stop Denver Intl
United Airlines Logo
10:30 am - 4:19 pmSAF  Santa Fe-DSM Des Moines
4h 49m1 stop Denver Intl
$314United Airlines
Tue, Sep 1 - Sat, Sep 5
United Airlines Logo
5:45 am - 9:46 amDSM  Des Moines-SAF Santa Fe
5h 01m1 stop Denver Intl
United Airlines Logo
7:10 am - 12:32 pmSAF  Santa Fe-DSM Des Moines
4h 22m1 stop Denver Intl
$314United Airlines
Tue, Sep 1 - Sat, Sep 5
American Airlines Logo
1:55 pm - 9:29 pmDSM  Des Moines-SAF Santa Fe
8h 34m1 stop Chicago O'Hare Intl
American Airlines Logo
6:48 am - 1:25 pmSAF  Santa Fe-DSM Des Moines
5h 37m1 stop Chicago O'Hare Intl
$314American Airlines
Tue, Sep 1 - Sat, Sep 5
American Airlines Logo
4:14 pm - 9:37 pmDSM  Des Moines-SAF Santa Fe
6h 23m1 stop Dallas/Fort Worth
American Airlines Logo
8:00 am - 3:10 pmSAF  Santa Fe-DSM Des Moines
6h 10m1 stop Dallas/Fort Worth
$314American Airlines
Fri, Sep 11 - Tue, Sep 15
United Airlines Logo
5:45 am - 9:46 amDSM  Des Moines-SAF Santa Fe
5h 01m1 stop Denver Intl
United Airlines Logo
1:22 pm - 8:26 pmSAF  Santa Fe-DSM Des Moines
6h 04m1 stop Denver Intl
$314United Airlines
Tue, Sep 1 - Sat, Sep 5
United Airlines Logo
1:35 pm - 5:11 pmDSM  Des Moines-SAF Santa Fe
4h 36m1 stop Denver Intl
United Airlines Logo
5:50 pm - 11:33 pmSAF  Santa Fe-DSM Des Moines
4h 43m1 stop Denver Intl
$314United Airlines
Sat, Sep 5 - Tue, Sep 8
United Airlines Logo
1:35 pm - 5:11 pmDSM  Des Moines-SAF Santa Fe
4h 36m1 stop Denver Intl
United Airlines Logo
10:30 am - 4:19 pmSAF  Santa Fe-DSM Des Moines
4h 49m1 stop Denver Intl
$329United Airlines
Fri, Aug 21 - Tue, Aug 25
American Airlines Logo
7:29 am - 12:59 pmDSM  Des Moines-SAF Santa Fe
6h 30m1 stop Chicago O'Hare Intl
American Airlines Logo
5:26 pm - 11:07 pmSAF  Santa Fe-DSM Des Moines
4h 41m1 stop Dallas/Fort Worth
$364American Airlines
Tue, Oct 13 - Sat, Oct 17
United Airlines Logo
9:13 am - 2:46 pmDSM  Des Moines-SAF Santa Fe
6h 33m1 stop Denver Intl
United Airlines Logo
3:21 pm - 11:44 pmSAF  Santa Fe-DSM Des Moines
7h 23m1 stop Denver Intl
$394United Airlines
Sat, Aug 29 - Tue, Sep 1
American Airlines Logo
1:55 pm - 9:29 pmDSM  Des Moines-SAF Santa Fe
8h 34m1 stop Chicago O'Hare Intl
American Airlines Logo
10:21 am - 12:35 amSAF  Santa Fe-DSM Des Moines
13h 14m2 stops Dallas/Fort Worth Chicago O'Hare Intl
$490American Airlines
Tue, Sep 1 - Sat, Sep 5

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American Airlines flights from Des Moines to Santa Fe

Our best American Airlines deals on Des Moines to Santa Fe flight tickets
American Airlines
Oct 13
DSM7:29 amDes Moines
6h 30m
1 stop
SAF12:59 pmSanta Fe
Oct 17
SAF5:26 pmSanta Fe
4h 41m
1 stop
DSM11:07 pmDes Moines
$364
American Airlines
Aug 20
DSM4:13 pmDes Moines
6h 45m
1 stop
SAF9:58 pmSanta Fe
Aug 23
SAF6:48 amSanta Fe
5h 37m
1 stop
DSM1:25 pmDes Moines
$374
American Airlines
Sep 1
DSM1:55 pmDes Moines
8h 34m
1 stop
SAF9:29 pmSanta Fe
Sep 5
SAF10:21 amSanta Fe
13h 14m
2 stops
DSM12:35 amDes Moines
$490

United Airlines flights from Des Moines to Santa Fe

Our best United Airlines deals on Des Moines to Santa Fe flight tickets
United Airlines
Sep 1
DSM11:33 amDes Moines
6h 38m
1 stop
SAF5:11 pmSanta Fe
Sep 5
SAF10:30 amSanta Fe
4h 49m
1 stop
DSM4:19 pmDes Moines
$314
United Airlines
Aug 21
DSM1:35 pmDes Moines
4h 36m
1 stop
SAF5:11 pmSanta Fe
Aug 25
SAF10:30 amSanta Fe
4h 49m
1 stop
DSM4:19 pmDes Moines
$329
United Airlines
Aug 29
DSM9:13 amDes Moines
6h 33m
1 stop
SAF2:46 pmSanta Fe
Sep 1
SAF3:21 pmSanta Fe
7h 23m
1 stop
DSM11:44 pmDes Moines
$394

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 7, 2026.
Use the filters below to find and compare flights from Des Moines to Santa Fe that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSanta Fe

DSM Des Moines - SAF Santa Fe

DSMSAF

Des Moines

Tue 9/1

11:33 am-5:11 pm

1 stop6h 38m

Santa Fe

Sat 9/5

10:30 am-4:19 pm

1 stop4h 49m

$314

Des MoinesSanta Fe

DSM Des Moines - SAF Santa Fe

DSMSAF

Des Moines

Tue 9/1

5:45 am-9:46 am

1 stop5h 01m

Santa Fe

Sat 9/5

7:10 am-12:32 pm

1 stop4h 22m

$314

Des MoinesSanta Fe

DSM Des Moines - SAF Santa Fe

DSMSAF

Des Moines

Tue 9/1

1:55 pm-9:29 pm

1 stop8h 34m

Santa Fe

Sat 9/5

6:48 am-1:25 pm

1 stop5h 37m

$314

Des MoinesSanta Fe

DSM Des Moines - SAF Santa Fe

DSMSAF

Des Moines

Fri 9/11

4:14 pm-9:37 pm

1 stop6h 23m

Santa Fe

Tue 9/15

8:00 am-3:10 pm

1 stop6h 10m

$314

Des MoinesSanta Fe

DSM Des Moines - SAF Santa Fe

DSMSAF

Des Moines

Tue 9/1

5:45 am-9:46 am

1 stop5h 01m

Santa Fe

Sat 9/5

1:22 pm-8:26 pm

1 stop6h 04m

$314
Quickest round-trip

Des MoinesSanta Fe

DSM Des Moines - SAF Santa Fe

DSMSAF

Des Moines

Sat 9/5

1:35 pm-5:11 pm

1 stop4h 36m

Santa Fe

Tue 9/8

5:50 pm-11:33 pm

1 stop4h 43m

$314

Des MoinesSanta Fe

DSM Des Moines - SAF Santa Fe

DSMSAF

Des Moines

Fri 8/21

1:35 pm-5:11 pm

1 stop4h 36m

Santa Fe

Tue 8/25

10:30 am-4:19 pm

1 stop4h 49m

$329

Des MoinesSanta Fe

DSM Des Moines - SAF Santa Fe

DSMSAF

Des Moines

Tue 10/13

7:29 am-12:59 pm

1 stop6h 30m

Santa Fe

Sat 10/17

5:26 pm-11:07 pm

1 stop4h 41m

$364

Des MoinesSanta Fe

DSM Des Moines - SAF Santa Fe

DSMSAF

Des Moines

Sat 8/29

9:13 am-2:46 pm

1 stop6h 33m

Santa Fe

Tue 9/1

3:21 pm-11:44 pm

1 stop7h 23m

$394

Des MoinesSanta Fe

DSM Des Moines - SAF Santa Fe

DSMSAF

Des Moines

Tue 9/1

1:55 pm-9:29 pm

1 stop8h 34m

Santa Fe

Sat 9/5

10:21 am-12:35 am

2 stops13h 14m

$490

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Santa Fe from

How to get the cheapest flight ticket from Des Moines to Santa Fe

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santa Fe?

The month of January is, on average, the cheapest month to fly to Santa Fe from Des Moines, with most prices found around $0. If you’re not able to fly to Santa Fe in January, then August is your next best option. Flight prices from Des Moines to Santa Fe during August average around $304.

When to book flights from Des Moines to Santa Fe

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santa Fe according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santa Fe (DSM to SAF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santa Fe

Fastest flight time

4h 32m

Direct flights

None
The fastest flight from Des Moines to Santa Fe takes 4h 32m
There are no direct flights from Des Moines to Santa Fe. There are no popular flight routes from Des Moines to Santa Fe.
Search flight deals

Frequently asked questions about flying from Des Moines to Santa Fe

  • How far is Des Moines to Santa Fe by plane?

    There are 777.7 mi between Des Moines and Santa Fe. A reasonable flight in good conditions will take 4h 32m.

  • When did momondo last update prices for flights from Des Moines Airport to Santa Fe Airport?

    Prices for flights from Des Moines Airport to Santa Fe Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Santa Fe Airport?

  • How old do you have to be to fly from Des Moines Airport to Santa Fe Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santa Fe Airport.

  • What documentation or ID do you need to fly to Santa Fe Airport?

    The necessary travel and health documents for your Santa Fe Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Santa Fe?

Best airlines flying from Des Moines to Santa Fe

Compare and see reviews for airlines that fly from Des Moines to Santa Fe with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $289Free CancellationRating
7.4
10,081 reviews
Search United Airlines flights

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa
Los Alamos

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santa Fe?

It is quick and easy to find Des Moines to Santa Fe flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santa Fe that suits you.

Can I find flights from Des Moines to Santa Fe with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Santa Fe flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Santa Fe?

momondo provides multiple filters to help you find the best flight to Santa Fe from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Santa Fe right now. Can momondo alert me if prices change?

Price alerts on flights to Santa Fe from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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