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Cheap flights from Des Moines to Memphis from $164

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Memphis departing on 3/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Memphis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
4:20 pm - 10:24 pm
DSM
-
MEM
6h 04m
1 stop
Delta Logo
6:00 am - 10:48 am
MEM
-
DSM
4h 48m
1 stop
$279Delta
Wed, Mar 4 - Wed, Mar 11
American Airlines Logo
1:48 pm - 10:41 pm
DSM
-
MEM
8h 53m
1 stop
American Airlines Logo
7:23 pm - 11:40 pm
MEM
-
DSM
4h 17m
1 stop
$289American Airlines
Wed, Mar 4 - Sun, Mar 8
Southwest Logo
5:35 am - 2:00 pm
DSM
-
MEM
8h 25m
2 stops
Southwest Logo
6:10 am - 1:15 pm
MEM
-
DSM
7h 05m
1 stop
$294Southwest
Sat, Apr 11 - Mon, Apr 13
American Airlines Logo
5:01 pm - 11:59 pm
DSM
-
MEM
6h 58m
1 stop
American Airlines Logo
6:36 am - 4:31 pm
MEM
-
DSM
9h 55m
1 stop
$295American Airlines
Fri, Apr 10 - Tue, Apr 14
Southwest Logo
5:35 am - 3:45 pm
DSM
-
MEM
10h 10m
2 stops
Southwest Logo
12:20 pm - 9:55 pm
MEM
-
DSM
9h 35m
2 stops
$299Southwest
Sat, Apr 11 - Mon, Apr 13
American Airlines Logo
11:09 am - 7:47 pm
DSM
-
MEM
8h 38m
2 stops
American Airlines Logo
6:36 am - 4:31 pm
MEM
-
DSM
9h 55m
1 stop
$300American Airlines
Fri, Apr 10 - Tue, Apr 14
Delta Logo
6:55 am - 11:47 am
DSM
-
MEM
4h 52m
1 stop
Delta Logo
6:00 am - 10:48 am
MEM
-
DSM
4h 48m
1 stop
$307Delta
Wed, Mar 18 - Wed, Mar 25
Delta Logo
4:25 pm - 8:26 pm
DSM
-
MEM
4h 01m
1 stop
Delta Logo
5:59 pm - 10:34 pm
MEM
-
DSM
4h 35m
1 stop
$308Delta
Fri, Apr 10 - Mon, Apr 13
American Airlines Logo
2:16 pm - 11:59 pm
DSM
-
MEM
9h 43m
1 stop
American Airlines Logo
9:39 am - 1:46 pm
MEM
-
DSM
4h 07m
1 stop
$310American Airlines
Thu, Apr 16 - Mon, Apr 20
American Airlines Logo
11:09 am - 7:47 pm
DSM
-
MEM
8h 38m
2 stops
American Airlines Logo
7:34 pm - 11:49 pm
MEM
-
DSM
4h 15m
1 stop
$313American Airlines
Fri, Apr 10 - Mon, Apr 13

Delta flights from Des Moines to Memphis

Our best Delta deals on Des Moines to Memphis flight tickets
Delta
Mar 4
DSM4:20 pmDes Moines
6h 04m
1 stop
MEM10:24 pmMemphis
Mar 11
MEM6:00 amMemphis
4h 48m
1 stop
DSM10:48 amDes Moines
$279
Delta
Mar 18
DSM6:55 amDes Moines
4h 52m
1 stop
MEM11:47 amMemphis
Mar 25
MEM6:00 amMemphis
4h 48m
1 stop
DSM10:48 amDes Moines
$307
Delta
Apr 10
DSM4:25 pmDes Moines
4h 01m
1 stop
MEM8:26 pmMemphis
Apr 13
MEM5:59 pmMemphis
4h 35m
1 stop
DSM10:34 pmDes Moines
$308

American Airlines flights from Des Moines to Memphis

Our best American Airlines deals on Des Moines to Memphis flight tickets
American Airlines
Mar 4
DSM1:48 pmDes Moines
8h 53m
1 stop
MEM10:41 pmMemphis
Mar 8
MEM7:23 pmMemphis
4h 17m
1 stop
DSM11:40 pmDes Moines
$289
American Airlines
Apr 10
DSM5:01 pmDes Moines
6h 58m
1 stop
MEM11:59 pmMemphis
Apr 14
MEM6:36 amMemphis
9h 55m
1 stop
DSM4:31 pmDes Moines
$295
American Airlines
Apr 10
DSM11:09 amDes Moines
8h 38m
2 stops
MEM7:47 pmMemphis
Apr 14
MEM6:36 amMemphis
9h 55m
1 stop
DSM4:31 pmDes Moines
$300

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Memphis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from Des Moines to Memphis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Wed 3/4

4:20 pm-10:24 pm

1 stop6h 04m

Memphis

Wed 3/11

6:00 am-10:48 am

1 stop4h 48m

$279

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Wed 3/4

1:48 pm-10:41 pm

1 stop8h 53m

Memphis

Sun 3/8

7:23 pm-11:40 pm

1 stop4h 17m

$289

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sat 4/11

5:35 am-2:00 pm

2 stops8h 25m

Memphis

Mon 4/13

6:10 am-1:15 pm

1 stop7h 05m

$294

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Fri 4/10

5:01 pm-11:59 pm

1 stop6h 58m

Memphis

Tue 4/14

6:36 am-4:31 pm

1 stop9h 55m

$295

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sat 4/11

5:35 am-3:45 pm

2 stops10h 10m

Memphis

Mon 4/13

12:20 pm-9:55 pm

2 stops9h 35m

$299

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Fri 4/10

11:09 am-7:47 pm

2 stops8h 38m

Memphis

Tue 4/14

6:36 am-4:31 pm

1 stop9h 55m

$300

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Wed 3/18

6:55 am-11:47 am

1 stop4h 52m

Memphis

Wed 3/25

6:00 am-10:48 am

1 stop4h 48m

$307

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Fri 4/10

4:25 pm-8:26 pm

1 stop4h 01m

Memphis

Mon 4/13

5:59 pm-10:34 pm

1 stop4h 35m

$308

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Thu 4/16

2:16 pm-11:59 pm

1 stop9h 43m

Memphis

Mon 4/20

9:39 am-1:46 pm

1 stop4h 07m

$310

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Fri 4/10

11:09 am-7:47 pm

2 stops8h 38m

Memphis

Mon 4/13

7:34 pm-11:49 pm

1 stop4h 15m

$313

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Memphis from

How to get the cheapest flight ticket from Des Moines to Memphis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Memphis?

Delta, Southwest, and United Airlines are the most popular carriers operating from Des Moines to Memphis

When to book flights from Des Moines to Memphis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Memphis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Memphis (DSM to MEM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Memphis

Fastest flight time

5h 00m

Direct flights

None
The fastest flight from Des Moines to Memphis takes 5h 00m
There are no direct flights from Des Moines to Memphis. There are no popular flight routes from Des Moines to Memphis.
Search flight deals

  • How far is Des Moines to Memphis by plane?

    Des Moines and Memphis are 484.7 mi apart from one another. In terms of flight time, this usually takes a little over 5h 00m.

  • When did momondo last update prices for flights from Des Moines Airport to Memphis Airport?

    Prices for flights from Des Moines Airport to Memphis Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Memphis Airport?

  • How old do you have to be to fly from Des Moines Airport to Memphis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Memphis Airport.

  • What documentation or ID do you need to fly to Memphis Airport?

    The travel and health documents you'll need for your trip to Memphis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Memphis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Memphis?

Best airlines flying from Des Moines to Memphis

Compare and see reviews for airlines that fly from Des Moines to Memphis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $257Free CancellationRating
7.9
8,146 reviews
Search Delta flights
American AirlinesPriceFrom $263Free CancellationRating
7.2
11,222 reviews
Search American Airlines flights

Traveling to a place near Memphis?

Book flights to Memphis if you plan to visit one of these locations
Southaven
Tunica
Germantown
West Memphis
Batesville
Forrest City
Cordova
Horn Lake
Marion
Osceola

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Memphis?

Finding the right flight to Memphis from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Memphis quick and easy, saving you time and money.

Can I find flights from Des Moines to Memphis with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Memphis from Des Moines with this policy.

How can momondo help me find flights from Des Moines to Memphis?

Once all potential Des Moines to Memphis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Memphis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Memphis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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