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Cheap flights from Des Moines to Memphis from $136

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Memphis departing on 4/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Memphis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
4:20 pm - 11:25 pm
DSM
-
MEM
7h 05m
1 stop
Southwest Logo
4:10 pm - 11:05 pm
MEM
-
DSM
6h 55m
1 stop
$285Southwest
Mon, May 11 - Mon, May 18
Southwest Logo
4:20 pm - 11:25 pm
DSM
-
MEM
7h 05m
1 stop
Southwest Logo
4:25 pm - 11:05 pm
MEM
-
DSM
6h 40m
2 stops
$290Southwest
Mon, May 11 - Mon, May 18
Southwest Logo
4:20 pm - 11:25 pm
DSM
-
MEM
7h 05m
1 stop
Southwest Logo
4:25 pm - 11:05 pm
MEM
-
DSM
6h 40m
2 stops
$325Southwest
Mon, May 4 - Mon, May 11
Southwest Logo
4:20 pm - 11:25 pm
DSM
-
MEM
7h 05m
1 stop
Southwest Logo
5:10 am - 11:25 am
MEM
-
DSM
6h 15m
1 stop
$347Southwest
Fri, May 8 - Sun, May 10
Southwest Logo
5:35 am - 11:40 am
DSM
-
MEM
6h 05m
1 stop
Southwest Logo
5:25 am - 8:55 pm
MEM
-
DSM
15h 30m
2 stops
$350Southwest
Sat, May 16 - Sat, May 23
American Airlines Logo
11:11 am - 7:47 pm
DSM
-
MEM
8h 36m
2 stops
American Airlines Logo
5:40 am - 11:26 am
MEM
-
DSM
5h 46m
1 stop
$352American Airlines
Fri, May 8 - Sun, May 10
Southwest Logo
5:35 am - 2:00 pm
DSM
-
MEM
8h 25m
2 stops
Southwest Logo
5:25 am - 8:55 pm
MEM
-
DSM
15h 30m
2 stops
$355Southwest
Sat, May 16 - Sat, May 23
Delta Logo
6:15 am - 11:16 am
DSM
-
MEM
5h 01m
1 stop
Delta Logo
6:00 am - 10:16 am
MEM
-
DSM
4h 16m
1 stop
$375Delta
Sat, May 16 - Sat, May 23
Southwest Logo
5:40 am - 5:50 pm
DSM
-
MEM
12h 10m
2 stops
Southwest Logo
5:15 am - 11:25 am
MEM
-
DSM
6h 10m
1 stop
$378Southwest
Thu, Sep 24 - Mon, Sep 28
Southwest Logo
5:40 am - 5:50 pm
DSM
-
MEM
12h 10m
2 stops
Southwest Logo
5:45 am - 1:45 pm
MEM
-
DSM
8h 00m
2 stops
$393Southwest
Thu, Sep 24 - Mon, Sep 28

Delta flights from Des Moines to Memphis

Our best Delta deals on Des Moines to Memphis flight tickets
Delta
May 16
DSM6:15 amDes Moines
5h 01m
1 stop
MEM11:16 amMemphis
May 23
MEM6:00 amMemphis
4h 16m
1 stop
DSM10:16 amDes Moines
$375
Delta
May 15
DSM5:28 pmDes Moines
4h 52m
1 stop
MEM10:20 pmMemphis
May 22
MEM6:00 amMemphis
6h 24m
1 stop
DSM12:24 pmDes Moines
$413
Delta
Apr 15
DSM2:44 pmDes Moines
6h 15m
1 stop
MEM8:59 pmMemphis
Apr 19
MEM5:15 amMemphis
5h 50m
1 stop
DSM11:05 amDes Moines
$447

American Airlines flights from Des Moines to Memphis

Our best American Airlines deals on Des Moines to Memphis flight tickets
American Airlines
May 8
DSM11:11 amDes Moines
8h 36m
2 stops
MEM7:47 pmMemphis
May 10
MEM5:40 amMemphis
5h 46m
1 stop
DSM11:26 amDes Moines
$352
American Airlines
Apr 15
DSM11:09 amDes Moines
8h 38m
2 stops
MEM7:47 pmMemphis
Apr 19
MEM6:40 amMemphis
4h 50m
1 stop
DSM11:30 amDes Moines
$452
American Airlines
Apr 3
DSM1:37 pmDes Moines
5h 10m
1 stop
MEM6:47 pmMemphis
Apr 5
MEM7:00 amMemphis
7h 56m
1 stop
DSM2:56 pmDes Moines
$567

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Memphis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 1, 2026.
Use the filters below to find and compare flights from Des Moines to Memphis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Mon 5/11

4:20 pm-11:25 pm

1 stop7h 05m

Memphis

Mon 5/18

4:10 pm-11:05 pm

1 stop6h 55m

$285

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Mon 5/11

4:20 pm-11:25 pm

1 stop7h 05m

Memphis

Mon 5/18

4:25 pm-11:05 pm

2 stops6h 40m

$290

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Mon 5/4

4:20 pm-11:25 pm

1 stop7h 05m

Memphis

Mon 5/11

4:25 pm-11:05 pm

2 stops6h 40m

$325

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Fri 5/8

4:20 pm-11:25 pm

1 stop7h 05m

Memphis

Sun 5/10

5:10 am-11:25 am

1 stop6h 15m

$347

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sat 5/16

5:35 am-11:40 am

1 stop6h 05m

Memphis

Sat 5/23

5:25 am-8:55 pm

2 stops15h 30m

$350

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Fri 5/8

11:11 am-7:47 pm

2 stops8h 36m

Memphis

Sun 5/10

5:40 am-11:26 am

1 stop5h 46m

$352

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sat 5/16

5:35 am-2:00 pm

2 stops8h 25m

Memphis

Sat 5/23

5:25 am-8:55 pm

2 stops15h 30m

$355
Quickest round-trip

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sat 5/16

6:15 am-11:16 am

1 stop5h 01m

Memphis

Sat 5/23

6:00 am-10:16 am

1 stop4h 16m

$375

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Thu 9/24

5:40 am-5:50 pm

2 stops12h 10m

Memphis

Mon 9/28

5:15 am-11:25 am

1 stop6h 10m

$378

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Thu 9/24

5:40 am-5:50 pm

2 stops12h 10m

Memphis

Mon 9/28

5:45 am-1:45 pm

2 stops8h 00m

$393

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Memphis from

How to get the cheapest flight ticket from Des Moines to Memphis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Memphis?

When to book flights from Des Moines to Memphis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Memphis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Memphis (DSM to MEM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Memphis

Fastest flight time

4h 34m

Direct flights

None
The fastest flight from Des Moines to Memphis takes 4h 34m
There are no direct flights from Des Moines to Memphis. There are no popular flight routes from Des Moines to Memphis.
Search flight deals

Frequently asked questions about flying from Des Moines to Memphis

  • How far is Des Moines to Memphis by plane?

    Des Moines and Memphis are 484.7 mi apart from one another. In terms of flight time, this usually takes a little over 4h 34m.

  • When did momondo last update prices for flights from Des Moines Airport to Memphis Airport?

    Prices for flights from Des Moines Airport to Memphis Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Memphis Airport?

  • How old do you have to be to fly from Des Moines Airport to Memphis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Memphis Airport.

  • What documentation or ID do you need to fly to Memphis Airport?

    The travel and health documents you'll need for your trip to Memphis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Memphis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Memphis?

Best airlines flying from Des Moines to Memphis

Compare and see reviews for airlines that fly from Des Moines to Memphis with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $263Free CancellationRating
7.1
11,544 reviews
Search American Airlines flights
DeltaPriceFrom $263Free CancellationRating
7.9
8,368 reviews
Search Delta flights

Traveling to a place near Memphis?

Book flights to Memphis if you plan to visit one of these locations
Southaven
Tunica
Germantown
West Memphis
Batesville
Forrest City
Cordova
Horn Lake
Marion
Osceola

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Memphis?

Finding the right flight to Memphis from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Memphis quick and easy, saving you time and money.

Can I find flights from Des Moines to Memphis with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Memphis from Des Moines with this policy.

How can momondo help me find flights from Des Moines to Memphis?

Once all potential Des Moines to Memphis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Memphis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Memphis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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