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Cheap flights from Des Moines to Memphis from $143

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Memphis departing on 6/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to Memphis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:03 pm - 10:21 pm
DSM
-
MEM
4h 18m
1 stop
Delta Logo
6:20 am - 10:43 am
MEM
-
DSM
4h 23m
1 stop
$296Delta
Tue, Jun 9 - Mon, Jun 15
United Airlines Logo
6:00 am - 11:05 am
DSM
-
MEM
5h 05m
1 stop
United Airlines Logo
7:25 am - 2:28 pm
MEM
-
DSM
7h 03m
1 stop
$314United Airlines
Wed, Jul 1 - Mon, Jul 6
Southwest Logo
5:20 am - 11:50 am
DSM
-
MEM
6h 30m
1 stop
Southwest Logo
12:15 pm - 11:30 pm
MEM
-
DSM
11h 15m
2 stops
$319Southwest
Wed, Jul 1 - Mon, Jul 6
Southwest Logo
5:20 am - 3:00 pm
DSM
-
MEM
9h 40m
2 stops
Southwest Logo
2:35 pm - 11:30 pm
MEM
-
DSM
8h 55m
2 stops
$324Southwest
Wed, Jul 1 - Mon, Jul 6
Southwest Logo
3:45 pm - 11:20 pm
DSM
-
MEM
7h 35m
1 stop
Southwest Logo
2:35 pm - 11:30 pm
MEM
-
DSM
8h 55m
2 stops
$325Southwest
Tue, Jun 9 - Mon, Jun 15
United Airlines Logo
6:50 pm - 11:21 pm
DSM
-
MEM
4h 31m
1 stop
United Airlines Logo
6:35 pm - 10:51 pm
MEM
-
DSM
4h 16m
1 stop
$329United Airlines
Mon, Jun 1 - Sun, Jun 14
Southwest Logo
5:20 am - 3:00 pm
DSM
-
MEM
9h 40m
2 stops
Southwest Logo
5:00 am - 2:50 pm
MEM
-
DSM
9h 50m
2 stops
$334Southwest
Tue, Jun 16 - Sat, Jun 20
Delta Logo
6:41 pm - 11:12 pm
DSM
-
MEM
4h 31m
1 stop
Delta Logo
6:00 am - 12:24 pm
MEM
-
DSM
6h 24m
1 stop
$347Delta
Sun, May 24 - Thu, May 28
United Airlines Logo
3:02 pm - 9:56 pm
DSM
-
MEM
6h 54m
1 stop
United Airlines Logo
6:15 am - 12:16 pm
MEM
-
DSM
6h 01m
1 stop
$351United Airlines
Tue, Aug 18 - Wed, Aug 19
Southwest Logo
6:10 am - 1:55 pm
DSM
-
MEM
7h 45m
1 stop
Southwest Logo
5:10 pm - 11:45 pm
MEM
-
DSM
6h 35m
2 stops
$352Southwest
Thu, Jul 16 - Sun, Jul 19

Southwest flights from Des Moines to Memphis

Our best Southwest deals on Des Moines to Memphis flight tickets
Southwest
Jul 1
DSM5:20 amDes Moines
6h 30m
1 stop
MEM11:50 amMemphis
Jul 6
MEM12:15 pmMemphis
11h 15m
2 stops
DSM11:30 pmDes Moines
$319
Southwest
Jul 1
DSM5:20 amDes Moines
9h 40m
2 stops
MEM3:00 pmMemphis
Jul 6
MEM2:35 pmMemphis
8h 55m
2 stops
DSM11:30 pmDes Moines
$324
Southwest
Jun 9
DSM3:45 pmDes Moines
7h 35m
1 stop
MEM11:20 pmMemphis
Jun 15
MEM2:35 pmMemphis
8h 55m
2 stops
DSM11:30 pmDes Moines
$325

American Airlines flights from Des Moines to Memphis

Our best American Airlines deals on Des Moines to Memphis flight tickets
American Airlines
Jun 5
DSM1:27 pmDes Moines
8h 14m
1 stop
MEM9:41 pmMemphis
Jun 12
MEM12:01 pmMemphis
6h 21m
1 stop
DSM6:22 pmDes Moines
$384
American Airlines
May 25
DSM6:02 amDes Moines
8h 05m
2 stops
MEM2:07 pmMemphis
May 29
MEM6:25 pmMemphis
5h 32m
1 stop
DSM11:57 pmDes Moines
$402
American Airlines
May 25
DSM6:02 amDes Moines
8h 05m
2 stops
MEM2:07 pmMemphis
May 28
MEM11:01 amMemphis
8h 31m
2 stops
DSM7:32 pmDes Moines
$428

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Memphis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 12, 2026.
Use the filters below to find and compare flights from Des Moines to Memphis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Tue 6/9

6:03 pm-10:21 pm

1 stop4h 18m

Memphis

Mon 6/15

6:20 am-10:43 am

1 stop4h 23m

$296

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Wed 7/1

6:00 am-11:05 am

1 stop5h 05m

Memphis

Mon 7/6

7:25 am-2:28 pm

1 stop7h 03m

$314

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Wed 7/1

5:20 am-11:50 am

1 stop6h 30m

Memphis

Mon 7/6

12:15 pm-11:30 pm

2 stops11h 15m

$319

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Wed 7/1

5:20 am-3:00 pm

2 stops9h 40m

Memphis

Mon 7/6

2:35 pm-11:30 pm

2 stops8h 55m

$324

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Tue 6/9

3:45 pm-11:20 pm

1 stop7h 35m

Memphis

Mon 6/15

2:35 pm-11:30 pm

2 stops8h 55m

$325

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Mon 6/1

6:50 pm-11:21 pm

1 stop4h 31m

Memphis

Sun 6/14

6:35 pm-10:51 pm

1 stop4h 16m

$329

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Tue 6/16

5:20 am-3:00 pm

2 stops9h 40m

Memphis

Sat 6/20

5:00 am-2:50 pm

2 stops9h 50m

$334

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sun 5/24

6:41 pm-11:12 pm

1 stop4h 31m

Memphis

Thu 5/28

6:00 am-12:24 pm

1 stop6h 24m

$347

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Tue 8/18

3:02 pm-9:56 pm

1 stop6h 54m

Memphis

Wed 8/19

6:15 am-12:16 pm

1 stop6h 01m

$351

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Thu 7/16

6:10 am-1:55 pm

1 stop7h 45m

Memphis

Sun 7/19

5:10 pm-11:45 pm

2 stops6h 35m

$352

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Memphis from

How to get the cheapest flight ticket from Des Moines to Memphis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Memphis?

American Airlines, Allegiant Air, and Southwest are the most popular carriers operating from Des Moines to Memphis

When to book flights from Des Moines to Memphis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Memphis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Memphis (DSM to MEM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Memphis

Fastest flight time

4h 18m

Direct flights

None
The fastest flight from Des Moines to Memphis takes 4h 18m
There are no direct flights from Des Moines to Memphis. There are no popular flight routes from Des Moines to Memphis.
Search flight deals

Frequently asked questions about flying from Des Moines to Memphis

  • How far is Des Moines to Memphis by plane?

    Des Moines and Memphis are 484.7 mi apart from one another. In terms of flight time, this usually takes a little over 4h 18m.

  • When did momondo last update prices for flights from Des Moines Airport to Memphis Airport?

    Prices for flights from Des Moines Airport to Memphis Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Memphis Airport?

  • How old do you have to be to fly from Des Moines Airport to Memphis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Memphis Airport.

  • What documentation or ID do you need to fly to Memphis Airport?

    The travel and health documents you'll need for your trip to Memphis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Memphis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Memphis?

Best airlines flying from Des Moines to Memphis

Compare and see reviews for airlines that fly from Des Moines to Memphis with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $263Free CancellationRating
7.1
11,661 reviews
Search American Airlines flights
DeltaPriceFrom $263Free CancellationRating
7.9
8,446 reviews
Search Delta flights

Traveling to a place near Memphis?

Book flights to Memphis if you plan to visit one of these locations
Southaven
Tunica
Germantown
West Memphis
Batesville
Forrest City
Cordova
Horn Lake
Osceola
Marion

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Memphis?

Finding the right flight to Memphis from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Memphis quick and easy, saving you time and money.

Can I find flights from Des Moines to Memphis with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Memphis from Des Moines with this policy.

How can momondo help me find flights from Des Moines to Memphis?

Once all potential Des Moines to Memphis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Memphis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Memphis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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