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Cheap flights from Des Moines to Boston from $359

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Boston departing on 1/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 11:35 am
DSM
-
MHT
4h 35m1 stop
American Airlines Logo
5:01 pm - 10:11 pm
MHT
-
DSM
6h 10m1 stop
$359American Airlines
jue., ene. 22 - jue., ene. 29
United Airlines Logo
5:30 am - 6:51 pm
DSM
-
MHT
12h 21m2 stops
United Airlines Logo
2:17 pm - 9:50 pm
MHT
-
DSM
8h 33m2 stops
$427United Airlines
mié., ene. 21 - mié., ene. 28
United Airlines Logo
8:00 am - 6:51 pm
DSM
-
MHT
9h 51m2 stops
United Airlines Logo
2:17 pm - 9:50 pm
MHT
-
DSM
8h 33m2 stops
$449United Airlines
jue., ene. 22 - jue., ene. 29
American Airlines Logo
4:25 pm - 11:46 pm
DSM
-
MHT
6h 21m1 stop
American Airlines Logo
5:30 am - 4:24 pm
MHT
-
DSM
11h 54m2 stops
$469American Airlines
jue., ene. 22 - jue., ene. 29
United Airlines Logo
8:00 am - 6:59 pm
DSM
-
MHT
9h 59m2 stops
United Airlines Logo
2:33 pm - 9:52 pm
MHT
-
DSM
8h 19m2 stops
$497United Airlines
mié., abr. 15 - mar., abr. 21
American Airlines Logo
7:10 am - 1:33 pm
DSM
-
MHT
5h 23m1 stop
American Airlines Logo
5:48 am - 12:14 pm
MHT
-
DSM
7h 26m1 stop
$507American Airlines
mar., abr. 14 - jue., abr. 23
American Airlines Logo
7:10 am - 1:33 pm
DSM
-
MHT
5h 23m1 stop
American Airlines Logo
5:06 pm - 9:39 pm
MHT
-
DSM
5h 33m1 stop
$516American Airlines
mié., abr. 15 - mar., abr. 21
American Airlines Logo
7:10 am - 1:33 pm
DSM
-
MHT
5h 23m1 stop
American Airlines Logo
5:48 am - 12:14 pm
MHT
-
DSM
7h 26m1 stop
$526American Airlines
mié., abr. 15 - jue., abr. 23
United Airlines Logo
8:00 am - 1:58 pm
DSM
-
MHT
28h 58m2 stops
United Airlines Logo
2:33 pm - 11:43 pm
MHT
-
DSM
10h 10m2 stops
$533United Airlines
sáb., feb. 14 - mié., feb. 18
United Airlines Logo
8:00 am - 6:59 pm
DSM
-
MHT
9h 59m2 stops
United Airlines Logo
2:33 pm - 9:52 pm
MHT
-
DSM
8h 19m2 stops
$537United Airlines
sáb., abr. 18 - mar., abr. 21

United Airlines flights from Des Moines to Manchester, New Hampshire

Our best United Airlines deals on Des Moines to Manchester, New Hampshire flight tickets
United Airlines
Jan 21
DSM5:30 amDes Moines
12h 21m
2 stops
MHT6:51 pmManchester
Jan 28
MHT2:17 pmManchester
8h 33m
2 stops
DSM9:50 pmDes Moines
$427
Find similar
United Airlines
Jan 22
DSM8:00 amDes Moines
9h 51m
2 stops
MHT6:51 pmManchester
Jan 29
MHT2:17 pmManchester
8h 33m
2 stops
DSM9:50 pmDes Moines
$449
Find similar
United Airlines
Apr 15
DSM8:00 amDes Moines
9h 59m
2 stops
MHT6:59 pmManchester
Apr 21
MHT2:33 pmManchester
8h 19m
2 stops
DSM9:52 pmDes Moines
$497
Find similar

American Airlines flights from Des Moines to Manchester, New Hampshire

Our best American Airlines deals on Des Moines to Manchester, New Hampshire flight tickets
American Airlines
Jan 22
DSM6:00 amDes Moines
4h 35m
1 stop
MHT11:35 amManchester
Jan 29
MHT5:01 pmManchester
6h 10m
1 stop
DSM10:11 pmDes Moines
$359
Find similar
American Airlines
Jan 22
DSM4:25 pmDes Moines
6h 21m
1 stop
MHT11:46 pmManchester
Jan 29
MHT5:30 amManchester
11h 54m
2 stops
DSM4:24 pmDes Moines
$469
Find similar
American Airlines
Apr 14
DSM7:10 amDes Moines
5h 23m
1 stop
MHT1:33 pmManchester
Apr 23
MHT5:48 amManchester
7h 26m
1 stop
DSM12:14 pmDes Moines
$507
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Manchester, New Hampshire that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated diciembre 9, 2025.
Use the filters below to find and compare flights from Des Moines to Manchester, New Hampshire that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

jue. 1/22

6:00 am-11:35 am

1 stop4h 35m

Manchester

jue. 1/29

5:01 pm-10:11 pm

1 stop6h 10m

$359

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

mié. 1/21

5:30 am-6:51 pm

2 stops12h 21m

Manchester

mié. 1/28

2:17 pm-9:50 pm

2 stops8h 33m

$427

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

jue. 1/22

8:00 am-6:51 pm

2 stops9h 51m

Manchester

jue. 1/29

2:17 pm-9:50 pm

2 stops8h 33m

$449

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

jue. 1/22

4:25 pm-11:46 pm

1 stop6h 21m

Manchester

jue. 1/29

5:30 am-4:24 pm

2 stops11h 54m

$469

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

mié. 4/15

8:00 am-6:59 pm

2 stops9h 59m

Manchester

mar. 4/21

2:33 pm-9:52 pm

2 stops8h 19m

$497

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

mar. 4/14

7:10 am-1:33 pm

1 stop5h 23m

Manchester

jue. 4/23

5:48 am-12:14 pm

1 stop7h 26m

$507

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

mié. 4/15

7:10 am-1:33 pm

1 stop5h 23m

Manchester

mar. 4/21

5:06 pm-9:39 pm

1 stop5h 33m

$516

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

mié. 4/15

7:10 am-1:33 pm

1 stop5h 23m

Manchester

jue. 4/23

5:48 am-12:14 pm

1 stop7h 26m

$526

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

sáb. 2/14

8:00 am-1:58 pm

2 stops28h 58m

Manchester

mié. 2/18

2:33 pm-11:43 pm

2 stops10h 10m

$533

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

sáb. 4/18

8:00 am-6:59 pm

2 stops9h 59m

Manchester

mar. 4/21

2:33 pm-9:52 pm

2 stops8h 19m

$537

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 11 resultsSorted by cheapest first
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See travel insights to Boston from

How to get the cheapest flight ticket from Des Moines to Manchester, New Hampshire

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Manchester, New Hampshire?

Our data shows that Saturday is the least expensive day to fly to Manchester, New Hampshire. Tickets to fly out on this day can be as low as $406. Be sure to avoid booking your departure on a Friday as prices are generally higher than usual. According to our data, the average ticket price to Manchester, New Hampshire on Friday is $486.

What is the cheapest time of day to depart on your flight to Manchester, New Hampshire?

Our most recent data shows that the best time of day to fly to Manchester, New Hampshire is in the morning. Flights from Des Moines to Manchester, New Hampshire during this time can be as low as $441. Flights in the afternoon are often more expensive with an average ticket price of $458.

When to book flights from Des Moines to Manchester, New Hampshire

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Manchester, New Hampshire according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Manchester, New Hampshire (DSM to MHT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Manchester, New Hampshire

Fastest flight time

9h 51m

Direct flights

None
The fastest flight from Des Moines to Manchester, New Hampshire takes 9h 51m
There are no direct flights from Des Moines to Manchester, New Hampshire. There are no popular flight routes from Des Moines to Manchester, New Hampshire.
Search flight deals

  • How far is Des Moines to Manchester by plane?

    The straight-line distance from Des Moines to Manchester is 1133.4 mi. 4h 35m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Manchester Airport?

    Prices for flights from Des Moines Airport to Manchester Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Manchester Airport?

  • How old do you have to be to fly from Des Moines Airport to Manchester Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Manchester Airport.

  • What documentation or ID do you need to fly to Manchester Airport?

    The travel and health documents you'll need for your trip to Manchester Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Manchester Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Manchester, New Hampshire?

Best airlines flying from Des Moines to Manchester, New Hampshire

Compare and see reviews for airlines that fly from Des Moines to Manchester, New Hampshire with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $310Free CancellationRating
7.2
11,045 reviews
Search American Airlines flights

Traveling to a place near Boston?

Book flights to Boston if you plan to visit one of these locations
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Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Manchester?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Manchester for you.

Can I find flights from Des Moines to Manchester with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Manchester flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Manchester?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Des Moines to Manchester.

I’m not ready to book a flight from Des Moines to Manchester right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Manchester flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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