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Cheap flights from Des Moines to Boston from $236

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Boston departing on 9/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

American Airlines Logo
6:07 pm - 11:56 pmDSM-MHT
4h 49m1 stop
American Airlines Logo
7:34 pm - 12:02 amMHT-DSM
5h 28m1 stop
$269American Airlines
Find Deal
Tue, Oct 14 - Wed, Oct 22
American Airlines Logo
3:56 pm - 11:51 pmDSM-MHT
6h 55m1 stop
American Airlines Logo
12:26 pm - 6:15 pmMHT-DSM
6h 49m1 stop
$303American Airlines
Find Deal
Tue, Oct 21 - Fri, Oct 31
Southwest Logo
6:20 am - 5:00 pmDSM-MHT
9h 40m2 stops
Southwest Logo
9:10 am - 7:55 pmMHT-DSM
11h 45m2 stops
$329Southwest
Find Deal
Tue, Oct 21 - Fri, Oct 31
American Airlines Logo
6:07 pm - 11:56 pmDSM-MHT
4h 49m1 stop
American Airlines Logo
5:15 pm - 11:59 pmMHT-DSM
7h 44m1 stop
$348American Airlines
Find Deal
Tue, Oct 7 - Fri, Oct 10
American Airlines Logo
11:15 am - 8:02 pmDSM-MHT
7h 47m1 stop
American Airlines Logo
5:20 pm - 10:02 pmMHT-DSM
5h 42m1 stop
$351American Airlines
Find Deal
Fri, Oct 31 - Mon, Nov 3
United Airlines Logo
3:15 pm - 11:44 pmDSM-MHT
7h 29m2 stops
United Airlines Logo
2:27 pm - 9:32 pmMHT-DSM
8h 05m2 stops
$401United Airlines
Find Deal
Mon, Oct 27 - Tue, Nov 4
Southwest Logo
8:25 am - 7:50 pmDSM-MHT
10h 25m2 stops
Southwest Logo
8:45 am - 9:35 pmMHT-DSM
13h 50m2 stops
$498Southwest
Find Deal
Fri, Oct 31 - Mon, Nov 3
Southwest Logo
5:30 pm - 8:35 amDSM-MHT
14h 05m2 stops
Southwest Logo
2:50 pm - 10:50 pmMHT-DSM
9h 00m2 stops
$535Southwest
Find Deal
Thu, Sep 25 - Fri, Sep 26
United Airlines Logo
12:52 pm - 1:47 pmDSM-MHT
23h 55m2 stops
United Airlines Logo
2:27 pm - 9:32 pmMHT-DSM
8h 05m2 stops
$570United Airlines
Find Deal
Sat, Oct 25 - Tue, Nov 4
United Airlines Logo
1:05 pm - 11:44 pmDSM-MHT
9h 39m2 stops
United Airlines Logo
9:30 am - 9:32 pmMHT-DSM
13h 02m3 stops
$577United Airlines
Find Deal
Fri, Oct 31 - Mon, Nov 3

Southwest flights from Des Moines to Manchester, New Hampshire

Our best Southwest deals on Des Moines to Manchester, New Hampshire flight tickets
Southwest
Oct 21
DSM6:20 amDes Moines
9h 40m
2 stops
MHT5:00 pmManchester
Oct 31
MHT9:10 amManchester
11h 45m
2 stops
DSM7:55 pmDes Moines
$329
Find similar
Southwest
Oct 31
DSM8:25 amDes Moines
10h 25m
2 stops
MHT7:50 pmManchester
Nov 3
MHT8:45 amManchester
13h 50m
2 stops
DSM9:35 pmDes Moines
$498
Find similar
Southwest
Sep 25
DSM5:30 pmDes Moines
14h 05m
2 stops
MHT8:35 amManchester
Sep 26
MHT2:50 pmManchester
9h 00m
2 stops
DSM10:50 pmDes Moines
$535
Find similar

United Airlines flights from Des Moines to Manchester, New Hampshire

Our best United Airlines deals on Des Moines to Manchester, New Hampshire flight tickets
United Airlines
Oct 27
DSM3:15 pmDes Moines
7h 29m
2 stops
MHT11:44 pmManchester
Nov 4
MHT2:27 pmManchester
8h 05m
2 stops
DSM9:32 pmDes Moines
$401
Find similar
United Airlines
Oct 25
DSM12:52 pmDes Moines
23h 55m
2 stops
MHT1:47 pmManchester
Nov 4
MHT2:27 pmManchester
8h 05m
2 stops
DSM9:32 pmDes Moines
$570
Find similar
United Airlines
Oct 31
DSM1:05 pmDes Moines
9h 39m
2 stops
MHT11:44 pmManchester
Nov 3
MHT9:30 amManchester
13h 02m
3 stops
DSM9:32 pmDes Moines
$577
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Manchester, New Hampshire that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 4, 2025.
Use the filters below to find and compare flights from Des Moines to Manchester, New Hampshire that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Tue 10/14

6:07 pm-11:56 pm

1 stop4h 49m

Manchester

Wed 10/22

7:34 pm-12:02 am

1 stop5h 28m

$269

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Tue 10/21

3:56 pm-11:51 pm

1 stop6h 55m

Manchester

Fri 10/31

12:26 pm-6:15 pm

1 stop6h 49m

$303

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Tue 10/21

6:20 am-5:00 pm

2 stops9h 40m

Manchester

Fri 10/31

9:10 am-7:55 pm

2 stops11h 45m

$329

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Tue 10/7

6:07 pm-11:56 pm

1 stop4h 49m

Manchester

Fri 10/10

5:15 pm-11:59 pm

1 stop7h 44m

$348

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Fri 10/31

11:15 am-8:02 pm

1 stop7h 47m

Manchester

Mon 11/3

5:20 pm-10:02 pm

1 stop5h 42m

$351

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Mon 10/27

3:15 pm-11:44 pm

2 stops7h 29m

Manchester

Tue 11/4

2:27 pm-9:32 pm

2 stops8h 05m

$401

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Fri 10/31

8:25 am-7:50 pm

2 stops10h 25m

Manchester

Mon 11/3

8:45 am-9:35 pm

2 stops13h 50m

$498

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Thu 9/25

5:30 pm-8:35 am

2 stops14h 05m

Manchester

Fri 9/26

2:50 pm-10:50 pm

2 stops9h 00m

$535

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Sat 10/25

12:52 pm-1:47 pm

2 stops23h 55m

Manchester

Tue 11/4

2:27 pm-9:32 pm

2 stops8h 05m

$570

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Fri 10/31

1:05 pm-11:44 pm

2 stops9h 39m

Manchester

Mon 11/3

9:30 am-9:32 pm

3 stops13h 02m

$577

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Boston from

How to get the cheapest flight ticket from Des Moines to Manchester, New Hampshire

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Manchester, New Hampshire?

Our data shows that Saturday is the least expensive day to fly to Manchester, New Hampshire. Tickets to fly out on this day can be as low as $406. Be sure to avoid booking your departure on a Friday as prices are generally higher than usual. According to our data, the average ticket price to Manchester, New Hampshire on Friday is $486.

What is the cheapest time of day to depart on your flight to Manchester, New Hampshire?

Our most recent data shows that the best time of day to fly to Manchester, New Hampshire is in the morning. Flights from Des Moines to Manchester, New Hampshire during this time can be as low as $441. Flights in the afternoon are often more expensive with an average ticket price of $458.

When to book flights from Des Moines to Manchester, New Hampshire

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Manchester, New Hampshire according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Manchester, New Hampshire (DSM to MHT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Manchester, New Hampshire

Direct flights

None
There are no direct flights from Des Moines to Manchester, New Hampshire. There are no popular flight routes from Des Moines to Manchester, New Hampshire.
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  • How far is Des Moines to Manchester by plane?

    The straight-line distance from Des Moines to Manchester is 1133.4 mi. 4h 49m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Manchester Airport?

    Prices for flights from Des Moines Airport to Manchester Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Manchester Airport?

  • How old do you have to be to fly from Des Moines Airport to Manchester Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Manchester Airport.

  • What documentation or ID do you need to fly to Manchester Airport?

    The travel and health documents you'll need for your trip to Manchester Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Manchester Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Manchester, New Hampshire?

Best airlines flying from Des Moines to Manchester, New Hampshire

Compare and see reviews for airlines that fly from Des Moines to Manchester, New Hampshire with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $316Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

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Why should I use momondo to find a flight deal from Des Moines to Manchester?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Manchester for you.

Can I find flights from Des Moines to Manchester with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Manchester flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Manchester?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Des Moines to Manchester.

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Yes. momondo can track prices for Des Moines to Manchester flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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