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Cheap flights from Des Moines to Boston from $254

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Boston departing on 6/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Boston

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:41 pm - 10:51 pm
DSM
-
MHT
8h 10m
1 stop
American Airlines Logo
5:12 pm - 11:44 pm
MHT
-
DSM
7h 32m
1 stop
$378American Airlines
Wed, Jul 29 - Wed, Aug 12
American Airlines Logo
6:11 am - 2:29 pm
DSM
-
MHT
7h 18m
1 stop
American Airlines Logo
2:49 pm - 10:06 pm
MHT
-
DSM
8h 17m
1 stop
$382American Airlines
Wed, Jul 29 - Wed, Aug 12
American Airlines Logo
5:00 am - 11:31 am
DSM
-
MHT
5h 31m
1 stop
American Airlines Logo
12:17 pm - 7:03 pm
MHT
-
DSM
7h 46m
1 stop
$387American Airlines
Wed, Jul 29 - Wed, Aug 12
American Airlines Logo
1:04 pm - 7:06 pm
DSM
-
MHT
5h 02m
1 stop
American Airlines Logo
5:10 pm - 12:09 am
MHT
-
DSM
7h 59m
1 stop
$399American Airlines
Fri, Jul 10 - Tue, Jul 14
American Airlines Logo
1:37 pm - 10:56 pm
DSM
-
MHT
8h 19m
1 stop
American Airlines Logo
5:32 pm - 11:50 pm
MHT
-
DSM
7h 18m
1 stop
$403American Airlines
Fri, Jun 26 - Wed, Jul 1
American Airlines Logo
1:35 pm - 10:52 pm
DSM
-
MHT
8h 17m
1 stop
American Airlines Logo
5:41 pm - 12:16 am
MHT
-
DSM
7h 35m
1 stop
$407American Airlines
Thu, Sep 3 - Tue, Sep 8
American Airlines Logo
6:00 am - 2:24 pm
DSM
-
MHT
7h 24m
1 stop
American Airlines Logo
8:14 am - 12:37 pm
MHT
-
DSM
5h 23m
1 stop
$410American Airlines
Thu, Sep 3 - Tue, Sep 8
American Airlines Logo
6:00 am - 2:24 pm
DSM
-
MHT
7h 24m
1 stop
American Airlines Logo
5:41 pm - 12:16 am
MHT
-
DSM
7h 35m
1 stop
$411American Airlines
Thu, Sep 3 - Tue, Sep 8
American Airlines Logo
1:41 pm - 10:51 pm
DSM
-
MHT
8h 10m
1 stop
American Airlines Logo
12:17 pm - 7:03 pm
MHT
-
DSM
7h 46m
1 stop
$430American Airlines
Wed, Jul 29 - Wed, Aug 12
Southwest Logo
4:40 pm - 12:05 am
DSM
-
MHT
6h 25m
2 stops
Southwest Logo
6:15 pm - 10:45 pm
MHT
-
DSM
5h 30m
1 stop
$432Southwest
Fri, Jul 10 - Tue, Jul 14

United Airlines flights from Des Moines to Manchester, New Hampshire

Our best United Airlines deals on Des Moines to Manchester, New Hampshire flight tickets
United Airlines
Sep 1
DSM8:00 amDes Moines
10h 00m
2 stops
MHT7:00 pmManchester
Sep 2
MHT2:46 pmManchester
8h 42m
2 stops
DSM10:28 pmDes Moines
$533
United Airlines
Jun 30
DSM6:00 amDes Moines
12h 02m
2 stops
MHT7:02 pmManchester
Jul 7
MHT2:37 pmManchester
9h 14m
2 stops
DSM10:51 pmDes Moines
$567
United Airlines
Jul 10
DSM6:00 amDes Moines
12h 02m
2 stops
MHT7:02 pmManchester
Jul 15
MHT2:37 pmManchester
9h 14m
2 stops
DSM10:51 pmDes Moines
$607

Southwest flights from Des Moines to Manchester, New Hampshire

Our best Southwest deals on Des Moines to Manchester, New Hampshire flight tickets
Southwest
Jul 10
DSM4:40 pmDes Moines
6h 25m
2 stops
MHT12:05 amManchester
Jul 14
MHT6:15 pmManchester
5h 30m
1 stop
DSM10:45 pmDes Moines
$432
Southwest
Jul 10
DSM4:40 pmDes Moines
6h 25m
2 stops
MHT12:05 amManchester
Jul 14
MHT3:55 pmManchester
7h 50m
2 stops
DSM10:45 pmDes Moines
$437
Southwest
Jun 26
DSM4:40 pmDes Moines
14h 25m
2 stops
MHT8:05 amManchester
Jul 3
MHT1:30 pmManchester
11h 00m
2 stops
DSM11:30 pmDes Moines
$443

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Manchester, New Hampshire that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 16, 2026.
Use the filters below to find and compare flights from Des Moines to Manchester, New Hampshire that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Wed 7/29

1:41 pm-10:51 pm

1 stop8h 10m

Manchester

Wed 8/12

5:12 pm-11:44 pm

1 stop7h 32m

$378

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Wed 7/29

6:11 am-2:29 pm

1 stop7h 18m

Manchester

Wed 8/12

2:49 pm-10:06 pm

1 stop8h 17m

$382

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Wed 7/29

5:00 am-11:31 am

1 stop5h 31m

Manchester

Wed 8/12

12:17 pm-7:03 pm

1 stop7h 46m

$387

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Fri 7/10

1:04 pm-7:06 pm

1 stop5h 02m

Manchester

Tue 7/14

5:10 pm-12:09 am

1 stop7h 59m

$399

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Fri 6/26

1:37 pm-10:56 pm

1 stop8h 19m

Manchester

Wed 7/1

5:32 pm-11:50 pm

1 stop7h 18m

$403

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Thu 9/3

1:35 pm-10:52 pm

1 stop8h 17m

Manchester

Tue 9/8

5:41 pm-12:16 am

1 stop7h 35m

$407

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Thu 9/3

6:00 am-2:24 pm

1 stop7h 24m

Manchester

Tue 9/8

8:14 am-12:37 pm

1 stop5h 23m

$410

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Thu 9/3

6:00 am-2:24 pm

1 stop7h 24m

Manchester

Tue 9/8

5:41 pm-12:16 am

1 stop7h 35m

$411

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Wed 7/29

1:41 pm-10:51 pm

1 stop8h 10m

Manchester

Wed 8/12

12:17 pm-7:03 pm

1 stop7h 46m

$430
Quickest round-trip

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Fri 7/10

4:40 pm-12:05 am

2 stops6h 25m

Manchester

Tue 7/14

6:15 pm-10:45 pm

1 stop5h 30m

$432

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Boston from

How to get the cheapest flight ticket from Des Moines to Manchester, New Hampshire

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Manchester, New Hampshire?

What is the cheapest month to fly to Manchester, New Hampshire?

If you aren’t able to travel during the month of December, then book flights to Manchester, New Hampshire from Des Moines during November instead. Flights to Manchester, New Hampshire in November, while not as cheap as those in December, still average around $0.

When to book flights from Des Moines to Manchester, New Hampshire

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Manchester, New Hampshire according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Manchester, New Hampshire (DSM to MHT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Manchester, New Hampshire

Fastest flight time

4h 15m

Direct flights

None
The fastest flight from Des Moines to Manchester, New Hampshire takes 4h 15m
There are no direct flights from Des Moines to Manchester, New Hampshire. There are no popular flight routes from Des Moines to Manchester, New Hampshire.
Search flight deals

Frequently asked questions about flying from Des Moines to Manchester, New Hampshire

  • How far is Des Moines to Manchester by plane?

    The straight-line distance from Des Moines to Manchester is 1133.4 mi. 4h 15m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Manchester Airport?

    Prices for flights from Des Moines Airport to Manchester Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Manchester Airport?

  • How old do you have to be to fly from Des Moines Airport to Manchester Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Manchester Airport.

  • What documentation or ID do you need to fly to Manchester Airport?

    The travel and health documents you'll need for your trip to Manchester Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Manchester Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Manchester, New Hampshire?

Best airlines flying from Des Moines to Manchester, New Hampshire

Compare and see reviews for airlines that fly from Des Moines to Manchester, New Hampshire with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $307Free CancellationRating
7.1
11,662 reviews
Search American Airlines flights

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Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Manchester?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Manchester for you.

Can I find flights from Des Moines to Manchester with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Manchester flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Manchester?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Des Moines to Manchester.

I’m not ready to book a flight from Des Moines to Manchester right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Manchester flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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