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Cheap flights from Des Moines to Boston from $138

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Boston departing on 4/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Boston

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
6:30 pm - 8:05 am
DSM
-
MHT
12h 35m
2 stops
Southwest Logo
7:40 am - 11:30 am
MHT
-
DSM
4h 50m
1 stop
$316Southwest
Tue, Apr 28 - Sat, May 2
Southwest Logo
6:30 pm - 8:05 am
DSM
-
MHT
12h 35m
2 stops
Southwest Logo
7:40 am - 8:55 pm
MHT
-
DSM
14h 15m
2 stops
$326Southwest
Tue, Apr 28 - Sat, May 2
American Airlines Logo
2:16 pm - 10:51 pm
DSM
-
MHT
7h 35m
1 stop
American Airlines Logo
5:42 pm - 11:49 pm
MHT
-
DSM
7h 07m
1 stop
$351American Airlines
Wed, Apr 29 - Tue, May 5
American Airlines Logo
5:01 pm - 10:51 pm
DSM
-
MHT
4h 50m
1 stop
American Airlines Logo
4:40 pm - 9:27 pm
MHT
-
DSM
5h 47m
1 stop
$357American Airlines
Tue, Apr 28 - Sat, May 2
American Airlines Logo
3:48 pm - 11:39 pm
DSM
-
MHT
6h 51m
1 stop
American Airlines Logo
5:54 pm - 11:26 pm
MHT
-
DSM
6h 32m
1 stop
$427American Airlines
Thu, Sep 3 - Tue, Sep 8
United Airlines Logo
8:00 am - 6:56 pm
DSM
-
MHT
9h 56m
2 stops
United Airlines Logo
2:36 pm - 11:44 pm
MHT
-
DSM
10h 08m
2 stops
$452United Airlines
Tue, May 5 - Tue, May 12
Southwest Logo
5:40 am - 2:55 pm
DSM
-
MHT
8h 15m
2 stops
Southwest Logo
8:00 am - 11:25 am
MHT
-
DSM
4h 25m
1 stop
$482Southwest
Thu, Sep 3 - Mon, Sep 14
Southwest Logo
5:40 am - 2:55 pm
DSM
-
MHT
8h 15m
2 stops
Southwest Logo
5:40 am - 1:45 pm
MHT
-
DSM
9h 05m
2 stops
$488Southwest
Thu, Sep 3 - Mon, Sep 14
American Airlines Logo
6:00 am - 12:10 pm
DSM
-
MHT
5h 10m
1 stop
American Airlines Logo
5:17 pm - 11:45 pm
MHT
-
DSM
7h 28m
1 stop
$517American Airlines
Thu, Aug 6 - Wed, Sep 2
United Airlines Logo
11:23 am - 11:59 pm
DSM
-
MHT
11h 36m
2 stops
United Airlines Logo
9:25 am - 7:24 pm
MHT
-
DSM
10h 59m
2 stops
$527United Airlines
Sat, Aug 8 - Wed, Sep 2

United Airlines flights from Des Moines to Manchester, New Hampshire

Our best United Airlines deals on Des Moines to Manchester, New Hampshire flight tickets
United Airlines
May 5
DSM5:30 amDes Moines
12h 26m
2 stops
MHT6:56 pmManchester
May 6
MHT2:36 pmManchester
10h 08m
2 stops
DSM11:44 pmDes Moines
$441
United Airlines
May 5
DSM8:00 amDes Moines
9h 56m
2 stops
MHT6:56 pmManchester
May 12
MHT2:36 pmManchester
10h 08m
2 stops
DSM11:44 pmDes Moines
$452
United Airlines
Aug 8
DSM6:00 amDes Moines
12h 02m
2 stops
MHT7:02 pmManchester
Aug 28
MHT9:25 amManchester
11h 52m
2 stops
DSM8:17 pmDes Moines
$527

American Airlines flights from Des Moines to Manchester, New Hampshire

Our best American Airlines deals on Des Moines to Manchester, New Hampshire flight tickets
American Airlines
Apr 29
DSM2:16 pmDes Moines
7h 35m
1 stop
MHT10:51 pmManchester
May 5
MHT5:42 pmManchester
7h 07m
1 stop
DSM11:49 pmDes Moines
$351
American Airlines
Apr 28
DSM2:16 pmDes Moines
7h 35m
1 stop
MHT10:51 pmManchester
May 2
MHT5:44 amManchester
8h 36m
1 stop
DSM1:20 pmDes Moines
$357
American Airlines
Sep 3
DSM3:48 pmDes Moines
6h 51m
1 stop
MHT11:39 pmManchester
Sep 8
MHT5:54 pmManchester
6h 32m
1 stop
DSM11:26 pmDes Moines
$427

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Manchester, New Hampshire that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Des Moines to Manchester, New Hampshire that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Tue 4/28

6:30 pm-8:05 am

2 stops12h 35m

Manchester

Sat 5/2

7:40 am-11:30 am

1 stop4h 50m

$316

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Tue 4/28

6:30 pm-8:05 am

2 stops12h 35m

Manchester

Sat 5/2

7:40 am-8:55 pm

2 stops14h 15m

$326

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Wed 4/29

2:16 pm-10:51 pm

1 stop7h 35m

Manchester

Tue 5/5

5:42 pm-11:49 pm

1 stop7h 07m

$351
Quickest round-trip

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Tue 4/28

5:01 pm-10:51 pm

1 stop4h 50m

Manchester

Sat 5/2

4:40 pm-9:27 pm

1 stop5h 47m

$357

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Thu 9/3

3:48 pm-11:39 pm

1 stop6h 51m

Manchester

Tue 9/8

5:54 pm-11:26 pm

1 stop6h 32m

$427

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Tue 5/5

8:00 am-6:56 pm

2 stops9h 56m

Manchester

Tue 5/12

2:36 pm-11:44 pm

2 stops10h 08m

$452

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Thu 9/3

5:40 am-2:55 pm

2 stops8h 15m

Manchester

Mon 9/14

8:00 am-11:25 am

1 stop4h 25m

$482

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Thu 9/3

5:40 am-2:55 pm

2 stops8h 15m

Manchester

Mon 9/14

5:40 am-1:45 pm

2 stops9h 05m

$488

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Thu 8/6

6:00 am-12:10 pm

1 stop5h 10m

Manchester

Wed 9/2

5:17 pm-11:45 pm

1 stop7h 28m

$517

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Sat 8/8

11:23 am-11:59 pm

2 stops11h 36m

Manchester

Wed 9/2

9:25 am-7:24 pm

2 stops10h 59m

$527

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Manchester, New Hampshire

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Manchester, New Hampshire?

When to book flights from Des Moines to Manchester, New Hampshire

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Manchester, New Hampshire according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Manchester, New Hampshire (DSM to MHT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Manchester, New Hampshire

Fastest flight time

4h 45m

Direct flights

None
The fastest flight from Des Moines to Manchester, New Hampshire takes 4h 45m
There are no direct flights from Des Moines to Manchester, New Hampshire. There are no popular flight routes from Des Moines to Manchester, New Hampshire.
Search flight deals

  • How far is Des Moines to Manchester by plane?

    The straight-line distance from Des Moines to Manchester is 1133.4 mi. 4h 45m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Manchester Airport?

    Prices for flights from Des Moines Airport to Manchester Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Manchester Airport?

  • How old do you have to be to fly from Des Moines Airport to Manchester Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Manchester Airport.

  • What documentation or ID do you need to fly to Manchester Airport?

    The travel and health documents you'll need for your trip to Manchester Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Manchester Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Manchester, New Hampshire?

Best airlines flying from Des Moines to Manchester, New Hampshire

Compare and see reviews for airlines that fly from Des Moines to Manchester, New Hampshire with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $307Free CancellationRating
7.1
11,488 reviews
Search American Airlines flights

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Why should I use momondo to find a flight deal from Des Moines to Manchester?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Manchester for you.

Can I find flights from Des Moines to Manchester with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Manchester flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Manchester?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Des Moines to Manchester.

I’m not ready to book a flight from Des Moines to Manchester right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Manchester flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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