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Cheap flights from Des Moines to Boston from $164

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Boston departing on 11/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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American Airlines Logo
3:18 pm - 11:48 pmDSM-MHT
7h 30m1 stop
American Airlines Logo
4:05 pm - 11:30 pmMHT-DSM
8h 25m1 stop
$327American Airlines
Find Deal
Wed, Nov 12 - Tue, Nov 18
American Airlines Logo
3:18 pm - 11:51 pmDSM-MHT
7h 33m1 stop
American Airlines Logo
5:16 pm - 10:04 pmMHT-DSM
5h 48m1 stop
$371American Airlines
Find Deal
Fri, Dec 5 - Fri, Dec 12
American Airlines Logo
2:08 pm - 10:48 pmDSM-MHT
7h 40m1 stop
American Airlines Logo
5:41 am - 12:23 pmMHT-DSM
7h 42m1 stop
$408American Airlines
Find Deal
Thu, Dec 4 - Thu, Dec 11
United Airlines Logo
1:05 pm - 11:44 pmDSM-MHT
9h 39m2 stops
United Airlines Logo
2:27 pm - 11:44 pmMHT-DSM
10h 17m2 stops
$427United Airlines
Find Deal
Wed, Nov 12 - Tue, Nov 18
American Airlines Logo
3:18 pm - 11:48 pmDSM-MHT
7h 30m1 stop
American Airlines Logo
11:29 am - 10:02 pmMHT-DSM
11h 33m2 stops
$429American Airlines
Find Deal
Wed, Nov 12 - Tue, Nov 18
American Airlines Logo
6:00 am - 11:47 amDSM-MHT
4h 47m1 stop
American Airlines Logo
5:41 am - 12:23 pmMHT-DSM
7h 42m1 stop
$488American Airlines
Find Deal
Thu, Dec 4 - Thu, Dec 11
United Airlines Logo
8:00 am - 6:53 pmDSM-MHT
9h 53m2 stops
United Airlines Logo
2:33 pm - 9:50 pmMHT-DSM
8h 17m2 stops
$497United Airlines
Find Deal
Tue, Mar 10 - Wed, Mar 11
American Airlines Logo
4:16 pm - 10:52 pmDSM-MHT
5h 36m1 stop
American Airlines Logo
5:20 pm - 11:55 pmMHT-DSM
7h 35m1 stop
$503American Airlines
Find Deal
Sat, Nov 22 - Mon, Nov 24
United Airlines Logo
5:45 am - 6:49 pmDSM-MHT
12h 04m2 stops
United Airlines Logo
7:27 pm - 9:37 pmMHT-DSM
27h 10m2 stops
$505United Airlines
Find Deal
Fri, Dec 5 - Fri, Dec 12
United Airlines Logo
1:35 pm - 11:44 pmDSM-MHT
9h 09m2 stops
United Airlines Logo
2:27 pm - 9:32 pmMHT-DSM
8h 05m2 stops
$507United Airlines
Find Deal
Sun, Nov 16 - Thu, Nov 20

American Airlines flights from Des Moines to Manchester, New Hampshire

Our best American Airlines deals on Des Moines to Manchester, New Hampshire flight tickets
American Airlines
Nov 12
DSM3:18 pmDes Moines
7h 30m
1 stop
MHT11:48 pmManchester
Nov 18
MHT4:05 pmManchester
8h 25m
1 stop
DSM11:30 pmDes Moines
$327
Find similar
American Airlines
Dec 5
DSM3:18 pmDes Moines
7h 33m
1 stop
MHT11:51 pmManchester
Dec 12
MHT5:16 pmManchester
5h 48m
1 stop
DSM10:04 pmDes Moines
$371
Find similar
American Airlines
Dec 4
DSM2:08 pmDes Moines
7h 40m
1 stop
MHT10:48 pmManchester
Dec 11
MHT5:41 amManchester
7h 42m
1 stop
DSM12:23 pmDes Moines
$408
Find similar

United Airlines flights from Des Moines to Manchester, New Hampshire

Our best United Airlines deals on Des Moines to Manchester, New Hampshire flight tickets
United Airlines
Nov 12
DSM1:05 pmDes Moines
9h 39m
2 stops
MHT11:44 pmManchester
Nov 18
MHT2:27 pmManchester
10h 17m
2 stops
DSM11:44 pmDes Moines
$427
Find similar
United Airlines
Mar 10
DSM8:00 amDes Moines
9h 53m
2 stops
MHT6:53 pmManchester
Mar 11
MHT2:33 pmManchester
8h 17m
2 stops
DSM9:50 pmDes Moines
$497
Find similar
United Airlines
Dec 5
DSM5:45 amDes Moines
12h 04m
2 stops
MHT6:49 pmManchester
Dec 12
MHT7:27 pmManchester
27h 10m
2 stops
DSM9:37 pmDes Moines
$505
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Manchester, New Hampshire that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 22, 2025.
Use the filters below to find and compare flights from Des Moines to Manchester, New Hampshire that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Wed 11/12

3:18 pm-11:48 pm

1 stop7h 30m

Manchester

Tue 11/18

4:05 pm-11:30 pm

1 stop8h 25m

$327

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Fri 12/5

3:18 pm-11:51 pm

1 stop7h 33m

Manchester

Fri 12/12

5:16 pm-10:04 pm

1 stop5h 48m

$371

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Thu 12/4

2:08 pm-10:48 pm

1 stop7h 40m

Manchester

Thu 12/11

5:41 am-12:23 pm

1 stop7h 42m

$408

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Wed 11/12

1:05 pm-11:44 pm

2 stops9h 39m

Manchester

Tue 11/18

2:27 pm-11:44 pm

2 stops10h 17m

$427

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Wed 11/12

3:18 pm-11:48 pm

1 stop7h 30m

Manchester

Tue 11/18

11:29 am-10:02 pm

2 stops11h 33m

$429

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Thu 12/4

6:00 am-11:47 am

1 stop4h 47m

Manchester

Thu 12/11

5:41 am-12:23 pm

1 stop7h 42m

$488

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Tue 3/10

8:00 am-6:53 pm

2 stops9h 53m

Manchester

Wed 3/11

2:33 pm-9:50 pm

2 stops8h 17m

$497

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Sat 11/22

4:16 pm-10:52 pm

1 stop5h 36m

Manchester

Mon 11/24

5:20 pm-11:55 pm

1 stop7h 35m

$503

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Fri 12/5

5:45 am-6:49 pm

2 stops12h 04m

Manchester

Fri 12/12

7:27 pm-9:37 pm

2 stops27h 10m

$505

Des MoinesManchester

DSM - MHT

DSMMHT

Des Moines

Sun 11/16

1:35 pm-11:44 pm

2 stops9h 09m

Manchester

Thu 11/20

2:27 pm-9:32 pm

2 stops8h 05m

$507

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Boston from

How to get the cheapest flight ticket from Des Moines to Manchester, New Hampshire

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Manchester, New Hampshire?

Our data shows that Saturday is the least expensive day to fly to Manchester, New Hampshire. Tickets to fly out on this day can be as low as $406. Be sure to avoid booking your departure on a Friday as prices are generally higher than usual. According to our data, the average ticket price to Manchester, New Hampshire on Friday is $486.

What is the cheapest time of day to depart on your flight to Manchester, New Hampshire?

Our most recent data shows that the best time of day to fly to Manchester, New Hampshire is in the morning. Flights from Des Moines to Manchester, New Hampshire during this time can be as low as $441. Flights in the afternoon are often more expensive with an average ticket price of $458.

When to book flights from Des Moines to Manchester, New Hampshire

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Manchester, New Hampshire according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Manchester, New Hampshire (DSM to MHT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Manchester, New Hampshire

Direct flights

None
There are no direct flights from Des Moines to Manchester, New Hampshire. There are no popular flight routes from Des Moines to Manchester, New Hampshire.
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  • How far is Des Moines to Manchester by plane?

    The straight-line distance from Des Moines to Manchester is 1133.4 mi. 4h 39m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Des Moines Airport to Manchester Airport?

    Prices for flights from Des Moines Airport to Manchester Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Manchester Airport?

  • How old do you have to be to fly from Des Moines Airport to Manchester Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Manchester Airport.

  • What documentation or ID do you need to fly to Manchester Airport?

    The travel and health documents you'll need for your trip to Manchester Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Manchester Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Manchester, New Hampshire?

Best airlines flying from Des Moines to Manchester, New Hampshire

Compare and see reviews for airlines that fly from Des Moines to Manchester, New Hampshire with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $310Free CancellationRating
7.2
11,028 reviews
Search American Airlines flights

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Why should I use momondo to find a flight deal from Des Moines to Manchester?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Manchester for you.

Can I find flights from Des Moines to Manchester with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Manchester flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Manchester?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Des Moines to Manchester.

I’m not ready to book a flight from Des Moines to Manchester right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Manchester flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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