Cheap flights from Denver to South Carolina from $112

The cheapest month to fly to South Carolina from Denver is in September. Flight prices, which tend to average around $389, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Denver during April instead. Flights to South Carolina in April, while not as cheap as those in September, still average around $393.

Our data shows that Sunday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $397. The most expensive day to fly to South Carolina is Monday, with ticket prices averaging around $519.

Our data shows that the cheapest Denver to South Carolina flights are usually those with departure times at noon. Our users have found flights to South Carolina at noon for as low as $408. Try not to purchase tickets in the evening because they tend to be around $622. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Denver Intl to Charleston for the best Denver Intl - South Carolina flight prices

You are more likely to see cheaper flights to South Carolina from Denver when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $420 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Denver for as low as $345 on momondo.

There are 4 cabin classes available to choose from on Denver to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Southwest, Delta, and American Airlines are the most popular carriers operating from Denver Intl to South Carolina

United Airlines, American Airlines and Southwest are the top three most popular airlines that fly to South Carolina from Denver according to our data. United Airlines is the first choice among our users, with 42% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 6 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

The number of flights available between Denver and South Carolina is 9 per day as of August 2026. The most frequent departure time is 9:00AM, with 65% of daily flights leaving at noon.

As of August 2026, there are 66 flights per week flying from Denver to South Carolina. The most common day of the week flights depart is Fri, with 20% of flights taking off on this day.