What airlines fly to South America?

Copa Airlines, American Airlines and United Airlines are the top three most popular airlines that fly to South America from Denver according to our data. Copa Airlines is the first choice among our users, with 30% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 8 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Denver Intl to South America?

Volaris, Copa Airlines, and Air Canada are the most popular carriers operating from Denver Intl to South America

When did momondo last update prices for flights from Denver Intl Airport to South America?

Prices for flights from Denver Intl Airport to South America are updated daily.

How many operators does momondo search for flights from Denver Intl Airport to South America?

As of February 2026, there are 8 operators available to choose from for flights from Denver Intl Airport to South America.

How old do you have to be to fly from Denver Intl Airport to South America?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Denver Intl Airport to South America.

What documentation or ID do you need to fly to South America?

The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$120 Cheap Flights from Denver to South America in 2026

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Find the cheapest flights from Denver to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

9:00 pm - 12:42 am

DEN

MDE

26h 42m

2 stops

10:52 am - 10:59 pm

MDE

DEN

13h 07m

1 stop

$335Multiple Airlines

Tue, May 5 - Wed, May 20

1:09 pm - 9:51 am

DEN

MDE

19h 42m

2 stops

1:52 pm - 11:09 pm

MDE

DEN

10h 17m

1 stop

$340Multiple Airlines

Wed, Mar 11 - Mon, Mar 16

5:00 am - 4:54 am

DEN

BOG

22h 54m

1 stop

8:30 am - 11:58 pm

BOG

DEN

16h 28m

1 stop

$357United Airlines

Sun, Apr 26 - Fri, May 1

5:00 am - 7:20 pm

DEN

BOG

13h 20m

1 stop

8:30 am - 10:15 pm

BOG

DEN

14h 45m

1 stop

$364United Airlines

Sun, Apr 26 - Fri, May 1

10:51 pm - 2:09 pm

DEN

UIO

14h 18m

1 stop

3:07 am - 6:25 pm

UIO

DEN

16h 18m

1 stop

$415Copa Airlines

Sat, Apr 25 - Fri, May 1

11:30 pm - 7:57 pm

DEN

UIO

19h 27m

1 stop

11:40 pm - 11:47 am

UIO

DEN

13h 07m

1 stop

$422American Airlines

Tue, Apr 14 - Wed, Apr 22

5:30 am - 10:24 pm

DEN

UIO

15h 54m

2 stops

11:40 pm - 11:47 am

UIO

DEN

13h 07m

1 stop

$426American Airlines

Tue, Apr 14 - Wed, Apr 22

9:38 pm - 8:41 am

DEN

CTG

9h 03m

1 stop

9:42 am - 5:16 pm

CTG

DEN

9h 34m

1 stop

$437Copa Airlines

Tue, Feb 24 - Fri, Mar 6

12:55 am - 1:15 pm

DEN

CTG

11h 20m

1 stop

2:30 pm - 12:33 am

CTG

DEN

11h 03m

1 stop

$449Delta

Wed, Apr 1 - Thu, Apr 16

12:59 am - 2:17 pm

DEN

CTG

11h 18m

1 stop

4:35 am - 7:21 pm

CTG

DEN

16h 46m

2 stops

$452Delta

Mon, Feb 23 - Thu, Mar 5

LATAM Airlines flights from Denver to South America

Our best LATAM Airlines deals on Denver to South America flight tickets

LATAM Airlines

Feb 24

DEN12:59 amDenver Intl

11h 26m

1 stop

BOG2:25 pmBogotá El Dorado

Mar 2

BOG3:55 pmBogotá El Dorado

10h 28m

1 stop

DEN12:23 amDenver Intl

$385

LATAM Airlines

Apr 19

DEN4:30 pmDenver Intl

28h 25m

1 stop

LIM9:55 pmLima J Chavez Intl

Apr 21

LIM8:55 amLima J Chavez Intl

16h 38m

2 stops

DEN12:33 amDenver Intl

$393

LATAM Airlines

Apr 15

DEN7:00 amDenver Intl

12h 10m

2 stops

BOG8:10 pmBogotá El Dorado

Apr 20

BOG2:55 pmBogotá El Dorado

10h 38m

1 stop

DEN12:33 amDenver Intl

$404

Delta flights from Denver to South America

Our best Delta deals on Denver to South America flight tickets

Delta

Feb 24

DEN12:59 amDenver Intl

13h 46m

2 stops

BOG4:45 pmBogotá El Dorado

Mar 2

BOG7:00 amBogotá El Dorado

19h 23m

2 stops

DEN12:23 amDenver Intl

$390

Delta

Apr 8

DEN12:55 amDenver Intl

15h 55m

2 stops

BOG5:50 pmBogotá El Dorado

Apr 15

BOG8:40 amBogotá El Dorado

14h 24m

2 stops

DEN10:04 pmDenver Intl

$410

Delta

Mar 16

DEN7:05 amDenver Intl

11h 25m

1 stop

BOG7:30 pmBogotá El Dorado

Apr 19

BOG2:55 pmBogotá El Dorado

19h 30m

1 stop

DEN9:25 amDenver Intl

$415

Fly from

Fly to

Route

Depart

Return

Price

DenverMedellín

DEN - MDE

DENMDE

Denver Intl

Tue 5/5

9:00 pm-12:42 am

2 stops26h 42m

Medellín Jose Maria Cordova Intl

Wed 5/20

10:52 am-10:59 pm

1 stop13h 07m

$335

DenverMedellín

DEN - MDE

DENMDE

Denver Intl

Wed 3/11

1:09 pm-9:51 am

2 stops19h 42m

Medellín Jose Maria Cordova Intl

Mon 3/16

1:52 pm-11:09 pm

1 stop10h 17m

$340

DenverBogotá

DEN - BOG

DENBOG

Denver Intl

Sun 4/26

5:00 am-4:54 am

1 stop22h 54m

Bogotá El Dorado

Fri 5/1

8:30 am-11:58 pm

1 stop16h 28m

$357

DenverBogotá

DEN - BOG

DENBOG

Denver Intl

Sun 4/26

5:00 am-7:20 pm

1 stop13h 20m

Bogotá El Dorado

Fri 5/1

8:30 am-10:15 pm

1 stop14h 45m

$364

DenverQuito

DEN - UIO

DENUIO

Denver Intl

Sat 4/25

10:51 pm-2:09 pm

1 stop14h 18m

Quito Mariscal Sucr

Fri 5/1

3:07 am-6:25 pm

1 stop16h 18m

$415

DenverQuito

DEN - UIO

DENUIO

Denver Intl

Tue 4/14

11:30 pm-7:57 pm

1 stop19h 27m

Quito Mariscal Sucr

Wed 4/22

11:40 pm-11:47 am

1 stop13h 07m

$422

DenverQuito

DEN - UIO

DENUIO

Denver Intl

Tue 4/14

5:30 am-10:24 pm

2 stops15h 54m

Quito Mariscal Sucr

Wed 4/22

11:40 pm-11:47 am

1 stop13h 07m

$426

DenverCartagena

DEN - CTG

DENCTG

Denver Intl

Tue 2/24

9:38 pm-8:41 am

1 stop9h 03m

Cartagena Rafael Nunez

Fri 3/6

9:42 am-5:16 pm

1 stop9h 34m

$437

DenverCartagena

DEN - CTG

DENCTG

Denver Intl

Wed 4/1

12:55 am-1:15 pm

1 stop11h 20m

Cartagena Rafael Nunez

Thu 4/16

2:30 pm-12:33 am

1 stop11h 03m

$449

DenverCartagena

DEN - CTG

DENCTG

Denver Intl

Mon 2/23

12:59 am-2:17 pm

1 stop11h 18m

Cartagena Rafael Nunez

Thu 3/5

4:35 am-7:21 pm

2 stops16h 46m

$452

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Denver to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, November is the cheapest month to fly from Denver to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $501. If you aren’t able to travel during the month of November, then book flights to South America from Denver during October instead. Flights to South America in October, while not as cheap as those in November, still average around $549.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from Denver when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $622 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Denver for as low as $506 on momondo.

Can stopping save me money on Denver to South America flights?

You could potentially save up to 13% on your flight if you consider stops on a Denver to South America flight.

Cheap Denver to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Denver to South America

Fastest flight time	8h 16m
Direct flights	None

The fastest flight from Denver to South America takes 8h 16m

There are no direct flights from Denver to South America. There are no popular flight routes from Denver to South America.

Search flight deals

When did momondo last update prices for flights from Denver Intl Airport to South America?
Prices for flights from Denver Intl Airport to South America are updated daily.
How many operators does momondo search for flights from Denver Intl Airport to South America?
As of February 2026, there are 8 operators available to choose from for flights from Denver Intl Airport to South America.
How old do you have to be to fly from Denver Intl Airport to South America?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Denver Intl Airport to South America.
What documentation or ID do you need to fly to South America?
The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Denver to South America

Compare and see reviews for airlines that fly from Denver to South America with momondo

Airline	Rating	Free Cancellation	Price
Volaris	PriceFrom $168	Free Cancellation	Rating 6.6 1,174 reviews	Search Volaris flights
Delta	PriceFrom $230	Free Cancellation	Rating 7.9 8,178 reviews	Search Delta flights
United Airlines	PriceFrom $280	Free Cancellation	Rating 7.4 9,279 reviews	Search United Airlines flights
Copa Airlines	PriceFrom $331	Free Cancellation	Rating 7.5 1,557 reviews	Search Copa Airlines flights
LATAM Airlines	PriceFrom $335	Free Cancellation	Rating 7.5 1,921 reviews	Search LATAM Airlines flights
American Airlines	PriceFrom $342	Free Cancellation	Rating 7.2 11,270 reviews	Search American Airlines flights
Aeromexico	PriceFrom $557	Free Cancellation	Rating 7.4 1,575 reviews	Search Aeromexico flights
Air Canada	PriceFrom $930	Free Cancellation	Rating 7.1 10,709 reviews	Search Air Canada flights

Why use momondo?

Why should I use momondo to find a flight deal from Denver to South America?

It is quick and easy to find Denver to South America flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South America that suits you.

Can I find flights from Denver to South America with flexible booking policies on momondo?

Flights from Denver to South America with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Denver to South America?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to South America from Denver.

I’m not ready to book a flight from Denver to South America right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Denver to South America flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.