Cheap flights from Columbus to St. Louis from $41

In general, January is the cheapest month to fly from Columbus to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $280. The month of September is another great option to travel to St. Louis, with average flight prices from Columbus averaging around $282.

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $394. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $554. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Columbus in the evening is the least expensive time of day to depart. momondo users have found prices as low as $421 when looking at flights departing in the evening. In the afternoon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $450 per ticket.

Fly from Columbus to Lambert-St Louis for the best Columbus - Lambert-St Louis flight prices

Frontier and Delta are the most popular carriers operating from Columbus to Lambert-St Louis

Southwest, American Airlines and United Airlines are the top three most popular airlines that fly to St. Louis from Columbus according to our data. Southwest is the first choice among our users, with 77% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 3 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

The number of flights available between Columbus and St. Louis is 1 per day as of September 2026. The most frequent departure time is 7:00AM, with 57% of daily flights leaving at noon.

As of September 2026, there are 9 flights per week flying from Columbus to St. Louis. The most common day of the week flights depart is Mon, with 22% of flights taking off on this day.