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Cheap flights from Columbia, Missouri to South Carolina from $319

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Columbia, Missouri to South Carolina departing on 10/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Columbia, Missouri to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:01 am - 3:02 pmCOU-HHH
8h 01m2 stops
American Airlines Logo
1:55 pm - 7:19 pmHHH-COU
6h 24m1 stop
$319American Airlines
Find Deal
Tue, Oct 28 - Sat, Nov 1
American Airlines Logo
6:01 am - 3:02 pmCOU-HHH
8h 01m2 stops
American Airlines Logo
1:55 pm - 7:19 pmHHH-COU
6h 24m1 stop
$324American Airlines
Find Deal
Tue, Oct 28 - Sat, Nov 1
American Airlines Logo
6:01 am - 3:02 pmCOU-HHH
8h 01m2 stops
American Airlines Logo
11:16 am - 7:19 pmHHH-COU
9h 03m2 stops
$329American Airlines
Find Deal
Tue, Oct 28 - Sat, Nov 1
American Airlines Logo
6:01 am - 3:02 pmCOU-HHH
8h 01m2 stops
American Airlines Logo
11:16 am - 7:19 pmHHH-COU
9h 03m2 stops
$354American Airlines
Find Deal
Tue, Oct 28 - Sat, Nov 1
American Airlines Logo
6:01 am - 11:05 amCOU-CLT
4h 04m1 stop
American Airlines Logo
5:29 am - 11:44 amCLT-COU
7h 15m1 stop
$400American Airlines
Find Deal
Sat, Apr 4 - Tue, Apr 7
American Airlines Logo
6:01 am - 11:05 amCOU-CLT
4h 04m1 stop
American Airlines Logo
1:22 pm - 7:57 pmCLT-COU
7h 35m2 stops
$406American Airlines
Find Deal
Sat, Apr 4 - Tue, Apr 7
American Airlines Logo
6:01 am - 3:42 pmCOU-CLT
8h 41m2 stops
American Airlines Logo
10:21 am - 7:57 pmCLT-COU
10h 36m2 stops
$411American Airlines
Find Deal
Sat, Apr 4 - Tue, Apr 7
American Airlines Logo
12:10 pm - 9:22 pmCOU-CHS
8h 12m2 stops
American Airlines Logo
7:16 am - 11:29 amCHS-COU
5h 13m1 stop
$416American Airlines
Find Deal
Wed, Feb 25 - Sat, Feb 28
United Airlines Logo
3:10 pm - 5:24 pmCOU-CLT
25h 14m1 stop
United Airlines Logo
5:35 pm - 2:35 pmCLT-COU
22h 00m1 stop
$456United Airlines
Find Deal
Fri, Jan 9 - Mon, Jan 12
United Airlines Logo
8:00 am - 3:09 pmCOU-CHS
30h 09m2 stops
United Airlines Logo
4:38 pm - 2:26 pmCHS-COU
22h 48m1 stop
$564United Airlines
Find Deal
Thu, Nov 27 - Thu, Dec 4

United Airlines flights from Columbia, Missouri to South Carolina

Our best United Airlines deals on Columbia, Missouri to South Carolina flight tickets
United Airlines
Jan 9
COU3:10 pmColumbia Regional
25h 14m
1 stop
CLT5:24 pmCharlotte Douglas
Jan 12
CLT5:35 pmCharlotte Douglas
22h 00m
1 stop
COU2:35 pmColumbia Regional
$456
Find similar
United Airlines
Nov 27
COU8:00 amColumbia Regional
30h 09m
2 stops
CHS3:09 pmCharleston
Dec 4
CHS4:38 pmCharleston
22h 48m
1 stop
COU2:26 pmColumbia Regional
$564
Find similar
United Airlines
Jan 9
COU8:09 amColumbia Regional
12h 07m
2 stops
CLT9:16 pmCharlotte Douglas
Jan 12
CLT11:15 amCharlotte Douglas
11h 22m
2 stops
COU9:37 pmColumbia Regional
$738
Find similar

American Airlines flights from Columbia, Missouri to South Carolina

Our best American Airlines deals on Columbia, Missouri to South Carolina flight tickets
American Airlines
Oct 28
COU6:01 amColumbia Regional
8h 01m
2 stops
HHH3:02 pmHilton Head Island
Nov 1
HHH1:55 pmHilton Head Island
6h 24m
1 stop
COU7:19 pmColumbia Regional
$319
Find similar
American Airlines
Oct 28
COU6:01 amColumbia Regional
8h 01m
2 stops
HHH3:02 pmHilton Head Island
Nov 1
HHH1:55 pmHilton Head Island
6h 24m
1 stop
COU7:19 pmColumbia Regional
$324
Find similar
American Airlines
Oct 28
COU6:01 amColumbia Regional
8h 01m
2 stops
HHH3:02 pmHilton Head Island
Nov 1
HHH11:16 amHilton Head Island
9h 03m
2 stops
COU7:19 pmColumbia Regional
$329
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Columbia, Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 13, 2025.
Use the filters below to find and compare flights from Columbia, Missouri to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbiaHilton Head Island

COU - HHH

COUHHH

Columbia Regional

Tue 10/28

6:01 am-3:02 pm

2 stops8h 01m

Hilton Head Island

Sat 11/1

1:55 pm-7:19 pm

1 stop6h 24m

$319

ColumbiaHilton Head Island

COU - HHH

COUHHH

Columbia Regional

Tue 10/28

6:01 am-3:02 pm

2 stops8h 01m

Hilton Head Island

Sat 11/1

1:55 pm-7:19 pm

1 stop6h 24m

$324

ColumbiaHilton Head Island

COU - HHH

COUHHH

Columbia Regional

Tue 10/28

6:01 am-3:02 pm

2 stops8h 01m

Hilton Head Island

Sat 11/1

11:16 am-7:19 pm

2 stops9h 03m

$329

ColumbiaHilton Head Island

COU - HHH

COUHHH

Columbia Regional

Tue 10/28

6:01 am-3:02 pm

2 stops8h 01m

Hilton Head Island

Sat 11/1

11:16 am-7:19 pm

2 stops9h 03m

$354

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Sat 4/4

6:01 am-11:05 am

1 stop4h 04m

Charlotte Douglas

Tue 4/7

5:29 am-11:44 am

1 stop7h 15m

$400

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Sat 4/4

6:01 am-11:05 am

1 stop4h 04m

Charlotte Douglas

Tue 4/7

1:22 pm-7:57 pm

2 stops7h 35m

$406

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Sat 4/4

6:01 am-3:42 pm

2 stops8h 41m

Charlotte Douglas

Tue 4/7

10:21 am-7:57 pm

2 stops10h 36m

$411

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Wed 2/25

12:10 pm-9:22 pm

2 stops8h 12m

Charleston

Sat 2/28

7:16 am-11:29 am

1 stop5h 13m

$416

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Fri 1/9

3:10 pm-5:24 pm

1 stop25h 14m

Charlotte Douglas

Mon 1/12

5:35 pm-2:35 pm

1 stop22h 00m

$456

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Thu 11/27

8:00 am-3:09 pm

2 stops30h 09m

Charleston

Thu 12/4

4:38 pm-2:26 pm

1 stop22h 48m

$564

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Columbia, Missouri to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Friday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $562. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $599.

Cheap Columbia, Missouri to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbia, Missouri to South Carolina

Direct flights

None
There are no direct flights from Columbia, Missouri to South Carolina. There are no popular flight routes from Columbia, Missouri to South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Columbia Regional Airport to South Carolina?

    Prices for flights from Columbia Regional Airport to South Carolina are refreshed on a daily basis.

  • How many operators does momondo search for flights from Columbia Regional Airport to South Carolina?

  • How old do you have to be to fly from Columbia Regional Airport to South Carolina?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Columbia, Missouri to South Carolina

Compare and see reviews for airlines that fly from Columbia, Missouri to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $424Free CancellationRating
7.2
11,045 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Columbia to South Carolina?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Columbia to South Carolina. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Columbia to South Carolina with flexible booking policies on momondo?

Yes. All flights to South Carolina from Columbia on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Columbia to South Carolina?

Once all potential Columbia to South Carolina flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Columbia to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Columbia to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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