What is the cheapest airline that flies from Columbia Regional to South Carolina?

American Airlines and United Airlines are the most popular carriers operating from Columbia Regional to South Carolina

When did momondo last update prices for flights from Columbia Regional Airport to South Carolina?

Prices for flights from Columbia Regional Airport to South Carolina are refreshed on a daily basis.

How many operators does momondo search for flights from Columbia Regional Airport to South Carolina?

The number of operators available for flights from Columbia Regional Airport to South Carolina is 2 as of October 2026.

How old do you have to be to fly from Columbia Regional Airport to South Carolina?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$125 Cheap Flights from Columbia, Missouri to South Carolina in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Columbia, Missouri to South Carolina

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

8:04 pm - 8:38 amCOU Columbia Regional-CHS Charleston

11h 34m1 stop Orlando Sanford Intl

4:50 pm - 2:25 pmCHS Charleston-COU Columbia Regional

22h 35m1 stop Orlando

$320Multiple Airlines

Fri, Nov 20 - Tue, Nov 24

6:28 pm - 11:55 pmCOU Columbia Regional-CAE Columbia Metropolitan

4h 27m1 stop Chicago O'Hare Intl

5:12 pm - 9:29 pmCAE Columbia Metropolitan-COU Columbia Regional

5h 17m1 stop Chicago O'Hare Intl

$328American Airlines

Sat, Nov 21 - Tue, Dec 1

6:50 am - 3:25 pmCOU Columbia Regional-GSP Greenville

7h 35m1 stop Chicago O'Hare Intl

3:55 pm - 9:40 pmGSP Greenville-COU Columbia Regional

6h 45m1 stop Chicago O'Hare Intl

$328American Airlines

Sat, Jan 9 - Sat, Jan 16

8:00 am - 1:39 pmCOU Columbia Regional-CHS Charleston

4h 39m1 stop Charlotte Douglas

4:11 pm - 9:38 pmCHS Charleston-COU Columbia Regional

6h 27m1 stop Chicago O'Hare Intl

$328American Airlines

Fri, Dec 25 - Fri, Jan 1

4:47 pm - 3:17 pmCOU Columbia Regional-GSP Greenville

21h 30m1 stop Tampa St. Petersburg

3:51 pm - 2:25 pmGSP Greenville-COU Columbia Regional

23h 34m1 stop Orlando Sanford Intl

$377Allegiant Air

Thu, Nov 19 - Tue, Nov 24

3:16 pm - 9:13 pmCOU Columbia Regional-CHS Charleston

4h 57m1 stop Chicago O'Hare Intl

6:05 am - 10:29 amCHS Charleston-COU Columbia Regional

5h 24m1 stop Chicago O'Hare Intl

$389United Airlines

Sat, Mar 27 - Wed, Mar 31

11:30 am - 11:23 pmCOU Columbia Regional-CHS Charleston

10h 53m2 stops Chicago O'Hare Intl Newark

6:43 pm - 10:58 pmCHS Charleston-COU Columbia Regional

5h 15m1 stop Chicago O'Hare Intl

$396United Airlines

Sat, Mar 27 - Wed, Mar 31

8:04 pm - 11:17 pmCOU Columbia Regional-CHS Charleston

26h 13m2 stops Orlando Sanford Intl Columbus

4:50 pm - 2:25 pmCHS Charleston-COU Columbia Regional

22h 35m1 stop Orlando

$421Multiple Airlines

Fri, Nov 20 - Tue, Nov 24

7:45 am - 1:46 pmCOU Columbia Regional-CHS Charleston

5h 01m1 stop Chicago O'Hare Intl

9:46 am - 2:37 pmCHS Charleston-COU Columbia Regional

5h 51m1 stop Chicago O'Hare Intl

$428United Airlines

Wed, Jan 6 - Sat, Jan 9

8:04 pm - 8:50 amCOU Columbia Regional-MYR Myrtle Beach Intl

11h 46m1 stop Orlando Sanford Intl

6:12 pm - 4:55 pmMYR Myrtle Beach Intl-COU Columbia Regional

23h 43m1 stop Tampa

$468Multiple Airlines

Fri, Nov 20 - Mon, Nov 23

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American Airlines flights from Columbia, Missouri to South Carolina

Our best American Airlines deals on Columbia, Missouri to South Carolina flight tickets

American Airlines

Dec 25

COU8:00 amColumbia Regional

4h 39m

1 stop

CHS1:39 pmCharleston

Jan 1

CHS4:11 pmCharleston

6h 27m

1 stop

COU9:38 pmColumbia Regional

$328

American Airlines

Dec 24

COU7:00 amColumbia Regional

6h 49m

1 stop

CHS2:49 pmCharleston

Dec 28

CHS4:11 pmCharleston

6h 27m

1 stop

COU9:38 pmColumbia Regional

$343

American Airlines

Nov 12

COU6:26 pmColumbia Regional

4h 51m

1 stop

CHS12:17 amCharleston

Nov 16

CHS7:26 pmCharleston

4h 16m

1 stop

COU10:42 pmColumbia Regional

$358

United Airlines flights from Columbia, Missouri to South Carolina

Our best United Airlines deals on Columbia, Missouri to South Carolina flight tickets

United Airlines

Mar 27

COU3:16 pmColumbia Regional

4h 57m

1 stop

CHS9:13 pmCharleston

Mar 31

CHS6:05 amCharleston

5h 24m

1 stop

COU10:29 amColumbia Regional

$389

United Airlines

Mar 27

COU11:30 amColumbia Regional

10h 53m

2 stops

CHS11:23 pmCharleston

Mar 31

CHS6:43 pmCharleston

5h 15m

1 stop

COU10:58 pmColumbia Regional

$396

United Airlines

Feb 6

COU7:45 amColumbia Regional

5h 01m

1 stop

CHS1:46 pmCharleston

Feb 9

CHS9:45 amCharleston

5h 52m

1 stop

COU2:37 pmColumbia Regional

$428

momondo Fare Finder

Use the filters below to find and compare flights from Columbia, Missouri to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbiaCharleston

COU Columbia Regional - CHS Charleston

COUCHS

Columbia Regional

Fri 11/20

8:04 pm-8:38 am

1 stop11h 34m

Charleston

Tue 11/24

4:50 pm-2:25 pm

1 stop22h 35m

$320

Quickest round-trip

ColumbiaColumbia

COU Columbia Regional - CAE Columbia Metropolitan

COUCAE

Columbia Regional

Sat 11/21

6:28 pm-11:55 pm

1 stop4h 27m

Columbia Metropolitan

Tue 12/1

5:12 pm-9:29 pm

1 stop5h 17m

$328

ColumbiaGreenville

COU Columbia Regional - GSP Greenville

COUGSP

Columbia Regional

Sat 1/9

6:50 am-3:25 pm

1 stop7h 35m

Greenville

Sat 1/16

3:55 pm-9:40 pm

1 stop6h 45m

$328

ColumbiaCharleston

COU Columbia Regional - CHS Charleston

COUCHS

Columbia Regional

Fri 12/25

8:00 am-1:39 pm

1 stop4h 39m

Charleston

Fri 1/1

4:11 pm-9:38 pm

1 stop6h 27m

$328

ColumbiaGreenville

COU Columbia Regional - GSP Greenville

COUGSP

Columbia Regional

Thu 11/19

4:47 pm-3:17 pm

1 stop21h 30m

Greenville

Tue 11/24

3:51 pm-2:25 pm

1 stop23h 34m

$377

ColumbiaCharleston

COU Columbia Regional - CHS Charleston

COUCHS

Columbia Regional

Sat 3/27

3:16 pm-9:13 pm

1 stop4h 57m

Charleston

Wed 3/31

6:05 am-10:29 am

1 stop5h 24m

$389

ColumbiaCharleston

COU Columbia Regional - CHS Charleston

COUCHS

Columbia Regional

Sat 3/27

11:30 am-11:23 pm

2 stops10h 53m

Charleston

Wed 3/31

6:43 pm-10:58 pm

1 stop5h 15m

$396

ColumbiaCharleston

COU Columbia Regional - CHS Charleston

COUCHS

Columbia Regional

Fri 11/20

8:04 pm-11:17 pm

2 stops26h 13m

Charleston

Tue 11/24

4:50 pm-2:25 pm

1 stop22h 35m

$421

ColumbiaCharleston

COU Columbia Regional - CHS Charleston

COUCHS

Columbia Regional

Wed 1/6

7:45 am-1:46 pm

1 stop5h 01m

Charleston

Sat 1/9

9:46 am-2:37 pm

1 stop5h 51m

$428

ColumbiaMyrtle Beach

COU Columbia Regional - MYR Myrtle Beach Intl

COUMYR

Columbia Regional

Fri 11/20

8:04 pm-8:50 am

1 stop11h 46m

Myrtle Beach Intl

Mon 11/23

6:12 pm-4:55 pm

1 stop23h 43m

$468

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Columbia, Missouri to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Columbia, Missouri is in January. Flight prices, which tend to average around $258, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of January, then book flights to South Carolina from Columbia, Missouri during February instead. Flights to South Carolina in February, while not as cheap as those in January, still average around $293.

Can stopping save me money on Columbia, Missouri to South Carolina flights?

You could potentially save up to 33% on your flight if you consider stops on a Columbia, Missouri to South Carolina flight.

Cheap Columbia, Missouri to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbia, Missouri to South Carolina

Best Price Found	$125
Fastest flight time	2h 10m
Direct flights	None

The best one-way flight to South Carolina from Columbia, Missouri in the past 72 hours is $125. The best round-trip flight deal from Columbia, Missouri to South Carolina found on momondo in the last 72 hours is $320.

The fastest flight from Columbia, Missouri to South Carolina takes 2h 10m

There are no direct flights from Columbia, Missouri to South Carolina. There are no popular flight routes from Columbia, Missouri to South Carolina.

Search flight deals

Frequently asked questions about flying from Columbia, Missouri to South Carolina

When did momondo last update prices for flights from Columbia Regional Airport to South Carolina?
Prices for flights from Columbia Regional Airport to South Carolina are refreshed on a daily basis.
How many operators does momondo search for flights from Columbia Regional Airport to South Carolina?
The number of operators available for flights from Columbia Regional Airport to South Carolina is 2 as of October 2026.
How old do you have to be to fly from Columbia Regional Airport to South Carolina?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Columbia, Missouri to South Carolina

Compare and see reviews for airlines that fly from Columbia, Missouri to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $263	Free Cancellation	Rating 7.3 10,451 reviews		Search United Airlines flights
American Airlines	PriceFrom $298	Free Cancellation	Rating 7.0 12,210 reviews		Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Columbia to South Carolina?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Columbia to South Carolina. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Columbia to South Carolina with flexible booking policies on momondo?

Yes. All flights to South Carolina from Columbia on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Columbia to South Carolina?

Once all potential Columbia to South Carolina flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Columbia to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Columbia to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.