Cheap flights from Columbia, Missouri to South Carolina from $214

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Columbia, Missouri to South Carolina departing on 4/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Columbia, Missouri to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
8:00 am - 1:55 pm
COU
-
CHS
4h 55m
1 stop
United Airlines Logo
4:55 pm - 9:56 pm
CHS
-
COU
6h 01m
1 stop
$258United Airlines
Sat, Apr 18 - Wed, Apr 22
United Airlines Logo
11:30 am - 5:13 pm
COU
-
CHS
4h 43m
1 stop
United Airlines Logo
6:00 am - 2:48 pm
CHS
-
COU
9h 48m
2 stops
$264United Airlines
Sat, Apr 18 - Wed, Apr 22
United Airlines Logo
2:41 pm - 9:31 pm
COU
-
CLT
5h 50m
1 stop
United Airlines Logo
8:00 am - 2:06 pm
CLT
-
COU
7h 06m
1 stop
$268United Airlines
Tue, Mar 10 - Sat, Mar 14
United Airlines Logo
11:30 am - 11:59 pm
COU
-
CHS
11h 29m
2 stops
United Airlines Logo
6:30 am - 2:48 pm
CHS
-
COU
9h 18m
2 stops
$269United Airlines
Sat, Apr 18 - Wed, Apr 22
United Airlines Logo
8:00 am - 9:15 pm
COU
-
CLT
12h 15m
2 stops
United Airlines Logo
8:00 am - 2:06 pm
CLT
-
COU
7h 06m
1 stop
$274United Airlines
Tue, Mar 10 - Sat, Mar 14
United Airlines Logo
3:05 pm - 9:48 pm
COU
-
CHS
5h 43m
1 stop
United Airlines Logo
3:19 pm - 9:15 pm
CHS
-
COU
6h 56m
1 stop
$293United Airlines
Tue, Aug 4 - Tue, Aug 11
United Airlines Logo
3:23 pm - 8:57 pm
COU
-
CLT
4h 34m
1 stop
United Airlines Logo
6:15 am - 10:55 am
CLT
-
COU
5h 40m
1 stop
$298United Airlines
Fri, Apr 24 - Wed, Apr 29
United Airlines Logo
3:05 pm - 9:48 pm
COU
-
CHS
5h 43m
1 stop
United Airlines Logo
10:23 am - 9:15 pm
CHS
-
COU
11h 52m
2 stops
$299United Airlines
Tue, Aug 4 - Tue, Aug 11
American Airlines Logo
6:00 am - 11:46 am
COU
-
MYR
4h 46m
1 stop
American Airlines Logo
12:16 pm - 6:00 pm
MYR
-
COU
6h 44m
1 stop
$457American Airlines
Wed, Apr 1 - Mon, Apr 6
American Airlines Logo
10:01 am - 10:28 pm
COU
-
MYR
11h 27m
2 stops
American Airlines Logo
5:19 pm - 10:36 pm
MYR
-
COU
6h 17m
1 stop
$463American Airlines
Wed, Apr 1 - Mon, Apr 6

American Airlines flights from Columbia, Missouri to South Carolina

Our best American Airlines deals on Columbia, Missouri to South Carolina flight tickets
American Airlines
Jun 27
COU7:16 amColumbia Regional
2h 14m
CLT10:30 amCharlotte Douglas
Jul 7
CLT9:22 pmCharlotte Douglas
2h 15m
COU10:37 pmColumbia Regional
$373
American Airlines
Apr 26
COU4:28 pmColumbia Regional
14h 38m
1 stop
CLT8:06 amCharlotte Douglas
May 1
CLT10:41 pmCharlotte Douglas
12h 05m
1 stop
COU9:46 amColumbia Regional
$379
American Airlines
Jun 27
COU6:27 pmColumbia Regional
4h 32m
1 stop
CLT11:59 pmCharlotte Douglas
Jul 7
CLT9:22 pmCharlotte Douglas
2h 15m
COU10:37 pmColumbia Regional
$382

United Airlines flights from Columbia, Missouri to South Carolina

Our best United Airlines deals on Columbia, Missouri to South Carolina flight tickets
United Airlines
Jun 24
COU3:05 pmColumbia Regional
5h 24m
1 stop
CLT9:29 pmCharlotte Douglas
Jun 27
CLT6:15 amCharlotte Douglas
5h 33m
1 stop
COU10:48 amColumbia Regional
$258
United Airlines
Jun 24
COU8:00 amColumbia Regional
11h 22m
2 stops
CLT8:22 pmCharlotte Douglas
Jun 27
CLT6:15 amCharlotte Douglas
5h 33m
1 stop
COU10:48 amColumbia Regional
$264
United Airlines
Aug 12
COU3:16 pmColumbia Regional
7h 18m
2 stops
CLT11:34 pmCharlotte Douglas
Aug 15
CLT10:23 amCharlotte Douglas
11h 52m
2 stops
COU9:15 pmColumbia Regional
$269

momondo Fare Finder

 
Customize your flight search to find flights from Columbia, Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 27, 2026.
Use the filters below to find and compare flights from Columbia, Missouri to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Sat 4/18

8:00 am-1:55 pm

1 stop4h 55m

Charleston

Wed 4/22

4:55 pm-9:56 pm

1 stop6h 01m

$258

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Sat 4/18

11:30 am-5:13 pm

1 stop4h 43m

Charleston

Wed 4/22

6:00 am-2:48 pm

2 stops9h 48m

$264

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Tue 3/10

2:41 pm-9:31 pm

1 stop5h 50m

Charlotte Douglas

Sat 3/14

8:00 am-2:06 pm

1 stop7h 06m

$268

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Sat 4/18

11:30 am-11:59 pm

2 stops11h 29m

Charleston

Wed 4/22

6:30 am-2:48 pm

2 stops9h 18m

$269

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Tue 3/10

8:00 am-9:15 pm

2 stops12h 15m

Charlotte Douglas

Sat 3/14

8:00 am-2:06 pm

1 stop7h 06m

$274

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Tue 8/4

3:05 pm-9:48 pm

1 stop5h 43m

Charleston

Tue 8/11

3:19 pm-9:15 pm

1 stop6h 56m

$293

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Fri 4/24

3:23 pm-8:57 pm

1 stop4h 34m

Charlotte Douglas

Wed 4/29

6:15 am-10:55 am

1 stop5h 40m

$298

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Tue 8/4

3:05 pm-9:48 pm

1 stop5h 43m

Charleston

Tue 8/11

10:23 am-9:15 pm

2 stops11h 52m

$299

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Wed 4/1

6:00 am-11:46 am

1 stop4h 46m

Myrtle Beach Intl

Mon 4/6

12:16 pm-6:00 pm

1 stop6h 44m

$457

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Wed 4/1

10:01 am-10:28 pm

2 stops11h 27m

Myrtle Beach Intl

Mon 4/6

5:19 pm-10:36 pm

1 stop6h 17m

$463

Flights are sorted by cheapest round-trip flights first.

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See travel insights to South Carolina from

How to get the cheapest flight ticket from Columbia, Missouri to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Columbia Regional to South Carolina?

United Airlines is the most popular carrier operating from Columbia Regional to South Carolina

Cheap Columbia, Missouri to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbia, Missouri to South Carolina

Fastest flight time

4h 40m

Direct flights

Mon, Tue, Thu, Fri, Sat and Sun

Airports in South Carolina

57 airports
The fastest flight from Columbia, Missouri to South Carolina takes 4h 40m
Direct flights go from Columbia, Missouri to South Carolina on Monday, Tuesday, Thursday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There are 57 airports in South Carolina. From Columbia, Missouri there are direct flights to Charlotte Douglas (CLT).
  • When did momondo last update prices for flights from Columbia Regional Airport to South Carolina?

    Prices for flights from Columbia Regional Airport to South Carolina are refreshed on a daily basis.

  • How many operators does momondo search for flights from Columbia Regional Airport to South Carolina?

  • How old do you have to be to fly from Columbia Regional Airport to South Carolina?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Columbia, Missouri to South Carolina

Compare and see reviews for airlines that fly from Columbia, Missouri to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $410Free CancellationRating
7.2
11,357 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Columbia to South Carolina?

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Can I find flights from Columbia to South Carolina with flexible booking policies on momondo?

Yes. All flights to South Carolina from Columbia on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Columbia to South Carolina?

Once all potential Columbia to South Carolina flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

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Of course. momondo tracks the price of Columbia to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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1 adult
Sun 3/29
Sun 4/5

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