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Cheap flights from Columbia, Missouri to South Carolina from $319

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Columbia, Missouri to South Carolina departing on 10/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Columbia, Missouri to South Carolina

Cheap round-trip flights

American Airlines Logo
6:01 am - 4:51 pmCOU-HHH
9h 50m2 stops
American Airlines Logo
11:16 am - 7:19 pmHHH-COU
9h 03m2 stops
$319American Airlines
Find Deal
Tue, Oct 28 - Sat, Nov 1
American Airlines Logo
6:01 am - 3:02 pmCOU-HHH
8h 01m2 stops
American Airlines Logo
1:55 pm - 7:19 pmHHH-COU
6h 24m1 stop
$359American Airlines
Find Deal
Tue, Oct 28 - Sat, Nov 1
American Airlines Logo
4:23 pm - 12:28 amCOU-CLT
7h 05m1 stop
American Airlines Logo
5:30 am - 12:00 pmCLT-COU
7h 30m1 stop
$400American Airlines
Find Deal
Wed, Sep 17 - Sun, Sep 21
United Airlines Logo
2:52 pm - 5:05 pmCOU-CLT
25h 13m1 stop
United Airlines Logo
10:25 am - 9:27 pmCLT-COU
12h 02m1 stop
$439United Airlines
Find Deal
Mon, Sep 29 - Mon, Oct 6
American Airlines Logo
6:24 am - 3:35 pmCOU-MYR
8h 11m2 stops
American Airlines Logo
5:15 am - 1:06 pmMYR-COU
8h 51m2 stops
$475American Airlines
Find Deal
Thu, Oct 2 - Sun, Oct 5
United Airlines Logo
2:52 pm - 5:05 pmCOU-CLT
25h 13m1 stop
United Airlines Logo
7:46 pm - 9:27 pmCLT-COU
26h 41m2 stops
$487United Airlines
Find Deal
Mon, Sep 29 - Mon, Oct 6
American Airlines Logo
11:43 am - 7:09 pmCOU-MYR
6h 26m2 stops
American Airlines Logo
5:25 am - 1:03 pmMYR-COU
8h 38m2 stops
$491American Airlines
Find Deal
Tue, Dec 9 - Sat, Dec 13
American Airlines Logo
4:23 pm - 10:54 pmCOU-MYR
5h 31m1 stop
American Airlines Logo
5:15 am - 1:06 pmMYR-COU
8h 51m2 stops
$492American Airlines
Find Deal
Thu, Oct 2 - Sun, Oct 5
American Airlines Logo
5:09 pm - 12:19 amCOU-CLT
6h 10m1 stop
American Airlines Logo
5:30 pm - 10:49 pmCLT-COU
6h 19m1 stop
$499American Airlines
Find Deal
Thu, Aug 28 - Tue, Sep 2
American Airlines Logo
4:23 pm - 10:54 pmCOU-MYR
5h 31m1 stop
American Airlines Logo
5:31 pm - 10:29 pmMYR-COU
5h 58m1 stop
$581American Airlines
Find Deal
Thu, Oct 2 - Sun, Oct 5

American Airlines flights from Columbia, Missouri to South Carolina

Our best American Airlines deals on Columbia, Missouri to South Carolina flight tickets
American Airlines
Oct 28
COU6:01 amColumbia Regional
9h 50m
2 stops
HHH4:51 pmHilton Head Island
Nov 1
HHH11:16 amHilton Head Island
9h 03m
2 stops
COU7:19 pmColumbia Regional
$319
Find similar
American Airlines
Oct 28
COU6:01 amColumbia Regional
8h 01m
2 stops
HHH3:02 pmHilton Head Island
Nov 1
HHH1:55 pmHilton Head Island
6h 24m
1 stop
COU7:19 pmColumbia Regional
$359
Find similar
American Airlines
Sep 17
COU4:23 pmColumbia Regional
7h 05m
1 stop
CLT12:28 amCharlotte Douglas
Sep 21
CLT5:30 amCharlotte Douglas
7h 30m
1 stop
COU12:00 pmColumbia Regional
$400
Find similar

United Airlines flights from Columbia, Missouri to South Carolina

Our best United Airlines deals on Columbia, Missouri to South Carolina flight tickets
United Airlines
Sep 29
COU2:52 pmColumbia Regional
25h 13m
1 stop
CLT5:05 pmCharlotte Douglas
Oct 6
CLT10:25 amCharlotte Douglas
12h 02m
1 stop
COU9:27 pmColumbia Regional
$439
Find similar
United Airlines
Sep 29
COU2:52 pmColumbia Regional
25h 13m
1 stop
CLT5:05 pmCharlotte Douglas
Oct 6
CLT7:46 pmCharlotte Douglas
26h 41m
2 stops
COU9:27 pmColumbia Regional
$487
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Columbia, Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 17, 2025.
Use the filters below to find and compare flights from Columbia, Missouri to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbiaHilton Head Island

COU - HHH

COUHHH

Columbia Regional

Tue 10/28

6:01 am-4:51 pm

2 stops9h 50m

Hilton Head Island

Sat 11/1

11:16 am-7:19 pm

2 stops9h 03m

$319

ColumbiaHilton Head Island

COU - HHH

COUHHH

Columbia Regional

Tue 10/28

6:01 am-3:02 pm

2 stops8h 01m

Hilton Head Island

Sat 11/1

1:55 pm-7:19 pm

1 stop6h 24m

$359

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Wed 9/17

4:23 pm-12:28 am

1 stop7h 05m

Charlotte Douglas

Sun 9/21

5:30 am-12:00 pm

1 stop7h 30m

$400

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Mon 9/29

2:52 pm-5:05 pm

1 stop25h 13m

Charlotte Douglas

Mon 10/6

10:25 am-9:27 pm

1 stop12h 02m

$439

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Thu 10/2

6:24 am-3:35 pm

2 stops8h 11m

Myrtle Beach Intl

Sun 10/5

5:15 am-1:06 pm

2 stops8h 51m

$475

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Mon 9/29

2:52 pm-5:05 pm

1 stop25h 13m

Charlotte Douglas

Mon 10/6

7:46 pm-9:27 pm

2 stops26h 41m

$487

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Tue 12/9

11:43 am-7:09 pm

2 stops6h 26m

Myrtle Beach Intl

Sat 12/13

5:25 am-1:03 pm

2 stops8h 38m

$491

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Thu 10/2

4:23 pm-10:54 pm

1 stop5h 31m

Myrtle Beach Intl

Sun 10/5

5:15 am-1:06 pm

2 stops8h 51m

$492

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Thu 8/28

5:09 pm-12:19 am

1 stop6h 10m

Charlotte Douglas

Tue 9/2

5:30 pm-10:49 pm

1 stop6h 19m

$499

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Thu 10/2

4:23 pm-10:54 pm

1 stop5h 31m

Myrtle Beach Intl

Sun 10/5

5:31 pm-10:29 pm

1 stop5h 58m

$581

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Columbia, Missouri to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Friday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $562. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $599.

Cheap Columbia, Missouri to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbia, Missouri to South Carolina

Best Price Found

$412

Fastest flight time

5h 07m

Direct flights

None

Airports in South Carolina

4 airports
The best one-way flight to South Carolina from Columbia, Missouri in the past 72 hours is $412. The best round-trip flight deal from Columbia, Missouri to South Carolina found on momondo in the last 72 hours is $319.
The fastest flight from Columbia, Missouri to South Carolina takes 5h 07m
There are no direct flights from Columbia, Missouri to South Carolina. Popular non-direct routes for this connection are Columbia Regional Airport - Charleston Airport, Columbia Regional Airport - Hilton Head Island Airport and Columbia Regional Airport - Charlotte Douglas Airport.
There are 4 airports near South Carolina: Myrtle Beach Intl (MYR), Hilton Head Island (HHH), Charlotte Douglas (CLT), Charleston (CHS)
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  • When did momondo last update prices for flights from Columbia Regional Airport to South Carolina?

    Prices for flights from Columbia Regional Airport to South Carolina are refreshed on a daily basis.

  • How many operators does momondo search for flights from Columbia Regional Airport to South Carolina?

  • How old do you have to be to fly from Columbia Regional Airport to South Carolina?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Columbia, Missouri to South Carolina

Compare and see reviews for airlines that fly from Columbia, Missouri to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $437Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Columbia to South Carolina?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Columbia to South Carolina. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Columbia to South Carolina with flexible booking policies on momondo?

Yes. All flights to South Carolina from Columbia on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Columbia to South Carolina?

Once all potential Columbia to South Carolina flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Columbia to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Columbia to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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