What is the cheapest airline that flies from Columbia Regional to South Carolina?

United Airlines and American Airlines are the most popular carriers operating from Columbia Regional to South Carolina

How many flights depart from Columbia, Missouri to South Carolina on average per week?

6 flights are operational weekly from Columbia, Missouri to South Carolina as of September 2026. The most popular departure day for this route is Mon, with 17% of flights per week taking off on this day.

When did momondo last update prices for flights from Columbia Regional Airport to South Carolina?

Prices for flights from Columbia Regional Airport to South Carolina are refreshed on a daily basis.

How many operators does momondo search for flights from Columbia Regional Airport to South Carolina?

The number of operators available for flights from Columbia Regional Airport to South Carolina is 2 as of September 2026.

How old do you have to be to fly from Columbia Regional Airport to South Carolina?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$156 Cheap Flights from Columbia, Missouri to South Carolina in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Columbia, Missouri to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:26 pm - 12:20 amCOU Columbia Regional-CHS Charleston

4h 54m1 stop Chicago O'Hare Intl

4:59 pm - 10:42 pmCHS Charleston-COU Columbia Regional

6h 43m1 stop Charlotte Douglas

$328American Airlines

Sat, Nov 7 - Thu, Nov 12

6:26 pm - 12:20 amCOU Columbia Regional-CHS Charleston

4h 54m1 stop Chicago O'Hare Intl

4:14 pm - 10:15 pmCHS Charleston-COU Columbia Regional

7h 01m1 stop Chicago O'Hare Intl

$328American Airlines

Fri, Nov 13 - Mon, Nov 16

6:15 am - 2:04 pmCOU Columbia Regional-CHS Charleston

6h 49m1 stop Chicago O'Hare Intl

6:50 pm - 10:55 pmCHS Charleston-COU Columbia Regional

5h 05m1 stop Chicago O'Hare Intl

$328United Airlines

Wed, Oct 7 - Tue, Oct 13

6:15 am - 2:04 pmCOU Columbia Regional-CHS Charleston

6h 49m1 stop Chicago O'Hare Intl

4:58 pm - 10:55 pmCHS Charleston-COU Columbia Regional

6h 57m1 stop Chicago O'Hare Intl

$328United Airlines

Wed, Oct 7 - Wed, Oct 14

11:33 am - 8:37 amCOU Columbia Regional-CLT Charlotte Douglas

20h 04m1 stop Orlando Sanford Intl

9:32 am - 12:08 pmCLT Charlotte Douglas-COU Columbia Regional

27h 36m1 stop Orlando

$333Multiple Airlines

Mon, Nov 2 - Thu, Nov 5

11:15 am - 12:15 amCOU Columbia Regional-CHS Charleston

12h 00m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National

6:50 pm - 10:55 pmCHS Charleston-COU Columbia Regional

5h 05m1 stop Chicago O'Hare Intl

$334United Airlines

Wed, Oct 7 - Tue, Oct 13

11:33 am - 8:37 amCOU Columbia Regional-CLT Charlotte Douglas

20h 04m1 stop Orlando Sanford Intl

9:32 am - 12:08 pmCLT Charlotte Douglas-COU Columbia Regional

27h 36m1 stop Orlando

$339Multiple Airlines

Mon, Nov 2 - Thu, Nov 5

12:59 pm - 5:05 pmCOU Columbia Regional-CLT Charlotte Douglas

27h 06m1 stop Orlando Sanford Intl

9:32 am - 12:08 pmCLT Charlotte Douglas-COU Columbia Regional

27h 36m1 stop Orlando

$347Multiple Airlines

Fri, Oct 30 - Thu, Nov 5

7:12 am - 1:36 pmCOU Columbia Regional-CHS Charleston

5h 24m1 stop Charlotte Douglas

4:10 pm - 9:29 pmCHS Charleston-COU Columbia Regional

6h 19m1 stop Chicago O'Hare Intl

$388American Airlines

Fri, Dec 25 - Fri, Jan 1

7:12 am - 1:36 pmCOU Columbia Regional-CHS Charleston

5h 24m1 stop Charlotte Douglas

4:10 pm - 9:29 pmCHS Charleston-COU Columbia Regional

6h 19m1 stop Chicago O'Hare Intl

$394American Airlines

Thu, Dec 24 - Mon, Dec 28

Cheap last minute flights

Enter your travel dates to find the best prices.

5:44 am - 1:16 pmCOU Columbia Regional-CHS Charleston

6h 32m1 stop Chicago O'Hare Intl

5:31 pm - 10:08 pmCHS Charleston-COU Columbia Regional

5h 37m1 stop Charlotte Douglas

$388American Airlines

Wed, Sep 23 - Mon, Sep 28

11:20 am - 7:40 pmCOU Columbia Regional-CHS Charleston

7h 20m1 stop Chicago O'Hare Intl

6:30 am - 10:39 amCHS Charleston-COU Columbia Regional

5h 09m1 stop Chicago O'Hare Intl

$388United Airlines

Wed, Sep 23 - Wed, Sep 30

6:15 am - 2:50 pmCOU Columbia Regional-CHS Charleston

7h 35m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

6:30 am - 10:39 amCHS Charleston-COU Columbia Regional

5h 09m1 stop Chicago O'Hare Intl

$394United Airlines

Wed, Sep 23 - Mon, Sep 28

6:15 am - 2:50 pmCOU Columbia Regional-CHS Charleston

7h 35m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

4:58 pm - 10:55 pmCHS Charleston-COU Columbia Regional

6h 57m1 stop Chicago O'Hare Intl

$394United Airlines

Wed, Sep 23 - Wed, Sep 30

6:15 am - 2:50 pmCOU Columbia Regional-CHS Charleston

7h 35m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

3:00 pm - 10:55 pmCHS Charleston-COU Columbia Regional

8h 55m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$399United Airlines

Wed, Sep 23 - Wed, Sep 30

3:31 pm - 10:59 pmCOU Columbia Regional-CHS Charleston

6h 28m1 stop Chicago O'Hare Intl

2:06 pm - 8:46 pmCHS Charleston-COU Columbia Regional

7h 40m1 stop Chicago O'Hare Intl

$418American Airlines

Mon, Sep 21 - Sat, Sep 26

5:44 am - 1:16 pmCOU Columbia Regional-CHS Charleston

6h 32m1 stop Chicago O'Hare Intl

5:31 pm - 10:08 pmCHS Charleston-COU Columbia Regional

5h 37m1 stop Charlotte Douglas

$418American Airlines

Wed, Sep 23 - Mon, Sep 28

6:15 am - 1:58 pmCOU Columbia Regional-CHS Charleston

6h 43m1 stop Chicago O'Hare Intl

4:58 pm - 10:55 pmCHS Charleston-COU Columbia Regional

6h 57m1 stop Chicago O'Hare Intl

$418United Airlines

Mon, Sep 21 - Sat, Sep 26

6:15 am - 2:50 pmCOU Columbia Regional-CHS Charleston

7h 35m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

6:30 am - 10:39 amCHS Charleston-COU Columbia Regional

5h 09m1 stop Chicago O'Hare Intl

$424United Airlines

Wed, Sep 23 - Mon, Sep 28

6:15 am - 2:50 pmCOU Columbia Regional-CHS Charleston

7h 35m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

6:00 am - 2:38 pmCHS Charleston-COU Columbia Regional

9h 38m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$429United Airlines

Wed, Sep 23 - Mon, Sep 28

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

United Airlines flights from Columbia, Missouri to South Carolina

Our best United Airlines deals on Columbia, Missouri to South Carolina flight tickets

United Airlines

Oct 7

COU11:15 amColumbia Regional

12h 00m

2 stops

CHS12:15 amCharleston

Oct 14

CHS6:50 pmCharleston

5h 05m

1 stop

COU10:55 pmColumbia Regional

$334

United Airlines

Oct 7

COU6:15 amColumbia Regional

7h 55m

2 stops

CHS3:10 pmCharleston

Oct 14

CHS3:00 pmCharleston

8h 55m

2 stops

COU10:55 pmColumbia Regional

$339

United Airlines

Sep 23

COU6:15 amColumbia Regional

7h 35m

2 stops

CHS2:50 pmCharleston

Sep 28

CHS6:30 amCharleston

5h 09m

1 stop

COU10:39 amColumbia Regional

$394

American Airlines flights from Columbia, Missouri to South Carolina

Our best American Airlines deals on Columbia, Missouri to South Carolina flight tickets

American Airlines

Nov 7

COU6:26 pmColumbia Regional

4h 54m

1 stop

CHS12:20 amCharleston

Nov 12

CHS4:59 pmCharleston

6h 43m

1 stop

COU10:42 pmColumbia Regional

$328

American Airlines

Sep 26

COU5:44 amColumbia Regional

6h 32m

1 stop

CHS1:16 pmCharleston

Oct 3

CHS6:44 amCharleston

5h 45m

1 stop

COU11:29 amColumbia Regional

$343

American Airlines

Dec 25

COU7:12 amColumbia Regional

5h 24m

1 stop

CHS1:36 pmCharleston

Jan 1

CHS4:10 pmCharleston

6h 19m

1 stop

COU9:29 pmColumbia Regional

$388

momondo Fare Finder

Use the filters below to find and compare flights from Columbia, Missouri to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

ColumbiaCharleston

COU Columbia Regional - CHS Charleston

COUCHS

Columbia Regional

Sat 11/7

6:26 pm-12:20 am

1 stop4h 54m

Charleston

Thu 11/12

4:59 pm-10:42 pm

1 stop6h 43m

$328

ColumbiaCharleston

COU Columbia Regional - CHS Charleston

COUCHS

Columbia Regional

Fri 11/13

6:26 pm-12:20 am

1 stop4h 54m

Charleston

Mon 11/16

4:14 pm-10:15 pm

1 stop7h 01m

$328

ColumbiaCharleston

COU Columbia Regional - CHS Charleston

COUCHS

Columbia Regional

Wed 10/7

6:15 am-2:04 pm

1 stop6h 49m

Charleston

Tue 10/13

6:50 pm-10:55 pm

1 stop5h 05m

$328

ColumbiaCharleston

COU Columbia Regional - CHS Charleston

COUCHS

Columbia Regional

Wed 10/7

6:15 am-2:04 pm

1 stop6h 49m

Charleston

Wed 10/14

4:58 pm-10:55 pm

1 stop6h 57m

$328

ColumbiaCharlotte

COU Columbia Regional - CLT Charlotte Douglas

COUCLT

Columbia Regional

Mon 11/2

11:33 am-8:37 am

1 stop20h 04m

Charlotte Douglas

Thu 11/5

9:32 am-12:08 pm

1 stop27h 36m

$333

ColumbiaCharleston

COU Columbia Regional - CHS Charleston

COUCHS

Columbia Regional

Wed 10/7

11:15 am-12:15 am

2 stops12h 00m

Charleston

Tue 10/13

6:50 pm-10:55 pm

1 stop5h 05m

$334

ColumbiaCharlotte

COU Columbia Regional - CLT Charlotte Douglas

COUCLT

Columbia Regional

Mon 11/2

11:33 am-8:37 am

1 stop20h 04m

Charlotte Douglas

Thu 11/5

9:32 am-12:08 pm

1 stop27h 36m

$339

ColumbiaCharlotte

COU Columbia Regional - CLT Charlotte Douglas

COUCLT

Columbia Regional

Fri 10/30

12:59 pm-5:05 pm

1 stop27h 06m

Charlotte Douglas

Thu 11/5

9:32 am-12:08 pm

1 stop27h 36m

$347

ColumbiaCharleston

COU Columbia Regional - CHS Charleston

COUCHS

Columbia Regional

Fri 12/25

7:12 am-1:36 pm

1 stop5h 24m

Charleston

Fri 1/1

4:10 pm-9:29 pm

1 stop6h 19m

$388

ColumbiaCharleston

COU Columbia Regional - CHS Charleston

COUCHS

Columbia Regional

Thu 12/24

7:12 am-1:36 pm

1 stop5h 24m

Charleston

Mon 12/28

4:10 pm-9:29 pm

1 stop6h 19m

$394

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Columbia, Missouri to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Columbia, Missouri is in January. Flight prices, which tend to average around $258, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of January, then book flights to South Carolina from Columbia, Missouri during February instead. Flights to South Carolina in February, while not as cheap as those in January, still average around $293.

Can stopping save me money on Columbia, Missouri to South Carolina flights?

You could potentially save up to 24% on your flight if you consider stops on a Columbia, Missouri to South Carolina flight.

Cheap Columbia, Missouri to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbia, Missouri to South Carolina

Best Price Found	$156
Fastest flight time	2h 11m
Direct flights	Every day
Airports in South Carolina	57 airports

The best one-way flight to South Carolina from Columbia, Missouri in the past 72 hours is $156. The best round-trip flight deal from Columbia, Missouri to South Carolina found on momondo in the last 72 hours is $328.

The fastest flight from Columbia, Missouri to South Carolina takes 2h 11m

Direct flights go from Columbia, Missouri to South Carolina every day.

There are 57 airports in South Carolina. From Columbia, Missouri there are direct flights to Charlotte Douglas (CLT).

Search flight deals

Frequently asked questions about flying from Columbia, Missouri to South Carolina

When did momondo last update prices for flights from Columbia Regional Airport to South Carolina?
Prices for flights from Columbia Regional Airport to South Carolina are refreshed on a daily basis.
How many operators does momondo search for flights from Columbia Regional Airport to South Carolina?
The number of operators available for flights from Columbia Regional Airport to South Carolina is 2 as of September 2026.
How old do you have to be to fly from Columbia Regional Airport to South Carolina?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Columbia, Missouri to South Carolina

Compare and see reviews for airlines that fly from Columbia, Missouri to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $263	Free Cancellation	Rating 7.4 10,214 reviews		Search United Airlines flights
American Airlines	PriceFrom $298	Free Cancellation	Rating 7.1 12,075 reviews		Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Columbia to South Carolina?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Columbia to South Carolina. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Columbia to South Carolina with flexible booking policies on momondo?

Yes. All flights to South Carolina from Columbia on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Columbia to South Carolina?

Once all potential Columbia to South Carolina flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Columbia to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Columbia to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.