Latest deals
Insights
FAQs
Reviews
Price Alerts

Cheap flights from Columbia, Missouri to South Carolina from $265

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Columbia, Missouri to South Carolina departing on 1/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Columbia, Missouri to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
8:09 am - 2:02 pm
COU
-
CHS
4h 53m1 stop
United Airlines Logo
4:41 pm - 9:37 pm
CHS
-
COU
5h 56m1 stop
$328United Airlines
Sat, Jan 31 - Wed, Feb 4
United Airlines Logo
8:09 am - 6:04 pm
COU
-
CHS
8h 55m2 stops
United Airlines Logo
4:41 pm - 9:37 pm
CHS
-
COU
5h 56m1 stop
$334United Airlines
Sat, Jan 31 - Wed, Feb 4
United Airlines Logo
8:45 am - 11:44 pm
COU
-
CHS
13h 59m2 stops
United Airlines Logo
11:10 am - 9:37 pm
CHS
-
COU
11h 27m2 stops
$339United Airlines
Sat, Jan 31 - Wed, Feb 4
United Airlines Logo
8:09 am - 2:02 pm
COU
-
CHS
4h 53m1 stop
United Airlines Logo
6:05 am - 10:42 am
CHS
-
COU
5h 37m1 stop
$363United Airlines
Mon, Jan 26 - Sun, Feb 1
United Airlines Logo
8:09 am - 7:04 pm
COU
-
CHS
9h 55m2 stops
United Airlines Logo
6:05 am - 10:42 am
CHS
-
COU
5h 37m1 stop
$369United Airlines
Mon, Jan 26 - Sun, Feb 1
United Airlines Logo
11:17 am - 11:44 pm
COU
-
CHS
11h 27m2 stops
United Airlines Logo
6:00 am - 2:35 pm
CHS
-
COU
9h 35m2 stops
$374United Airlines
Mon, Jan 26 - Sun, Feb 1
United Airlines Logo
3:16 pm - 9:23 pm
COU
-
CLT
5h 07m1 stop
United Airlines Logo
5:28 pm - 9:10 pm
CLT
-
COU
4h 42m1 stop
$400United Airlines
Sat, Apr 4 - Tue, Apr 7
United Airlines Logo
11:25 am - 5:07 pm
COU
-
CLT
4h 42m1 stop
United Airlines Logo
11:08 am - 9:10 pm
CLT
-
COU
11h 02m2 stops
$406United Airlines
Sat, Apr 4 - Tue, Apr 7
American Airlines Logo
6:33 pm - 2:27 pm
COU
-
HHH
18h 54m2 stops
American Airlines Logo
4:15 pm - 9:36 am
HHH
-
COU
18h 21m2 stops
$494American Airlines
Thu, Feb 12 - Wed, Feb 18
American Airlines Logo
5:57 am - 11:37 am
COU
-
MYR
4h 40m1 stop
American Airlines Logo
5:28 am - 11:08 am
MYR
-
COU
6h 40m2 stops
$573American Airlines
Sat, Apr 25 - Fri, May 1

United Airlines flights from Columbia, Missouri to South Carolina

Our best United Airlines deals on Columbia, Missouri to South Carolina flight tickets
United Airlines
Jan 31
COU8:09 amColumbia Regional
4h 53m
1 stop
CHS2:02 pmCharleston
Feb 4
CHS4:41 pmCharleston
5h 56m
1 stop
COU9:37 pmColumbia Regional
$328
Find similar
United Airlines
Jan 31
COU8:09 amColumbia Regional
8h 55m
2 stops
CHS6:04 pmCharleston
Feb 4
CHS4:41 pmCharleston
5h 56m
1 stop
COU9:37 pmColumbia Regional
$334
Find similar
United Airlines
Jan 31
COU8:45 amColumbia Regional
13h 59m
2 stops
CHS11:44 pmCharleston
Feb 4
CHS11:10 amCharleston
11h 27m
2 stops
COU9:37 pmColumbia Regional
$339
Find similar

American Airlines flights from Columbia, Missouri to South Carolina

Our best American Airlines deals on Columbia, Missouri to South Carolina flight tickets
American Airlines
Dec 23
COU3:20 pmColumbia Regional
4h 15m
1 stop
CLT8:35 pmCharlotte Douglas
Dec 27
CLT4:38 pmCharlotte Douglas
6h 21m
1 stop
COU9:59 pmColumbia Regional
$418
Find similar
American Airlines
Feb 12
COU6:33 pmColumbia Regional
18h 54m
2 stops
HHH2:27 pmHilton Head Island
Feb 18
HHH4:15 pmHilton Head Island
18h 21m
2 stops
COU9:36 amColumbia Regional
$494
Find similar
American Airlines
Apr 25
COU5:57 amColumbia Regional
4h 40m
1 stop
MYR11:37 amMyrtle Beach Intl
May 1
MYR5:28 amMyrtle Beach Intl
6h 40m
2 stops
COU11:08 amColumbia Regional
$573
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Columbia, Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Columbia, Missouri to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Sat 1/31

8:09 am-2:02 pm

1 stop4h 53m

Charleston

Wed 2/4

4:41 pm-9:37 pm

1 stop5h 56m

$328

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Sat 1/31

8:09 am-6:04 pm

2 stops8h 55m

Charleston

Wed 2/4

4:41 pm-9:37 pm

1 stop5h 56m

$334

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Sat 1/31

8:45 am-11:44 pm

2 stops13h 59m

Charleston

Wed 2/4

11:10 am-9:37 pm

2 stops11h 27m

$339

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Mon 1/26

8:09 am-2:02 pm

1 stop4h 53m

Charleston

Sun 2/1

6:05 am-10:42 am

1 stop5h 37m

$363

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Mon 1/26

8:09 am-7:04 pm

2 stops9h 55m

Charleston

Sun 2/1

6:05 am-10:42 am

1 stop5h 37m

$369

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Mon 1/26

11:17 am-11:44 pm

2 stops11h 27m

Charleston

Sun 2/1

6:00 am-2:35 pm

2 stops9h 35m

$374

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Sat 4/4

3:16 pm-9:23 pm

1 stop5h 07m

Charlotte Douglas

Tue 4/7

5:28 pm-9:10 pm

1 stop4h 42m

$400

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Sat 4/4

11:25 am-5:07 pm

1 stop4h 42m

Charlotte Douglas

Tue 4/7

11:08 am-9:10 pm

2 stops11h 02m

$406

ColumbiaHilton Head Island

COU - HHH

COUHHH

Columbia Regional

Thu 2/12

6:33 pm-2:27 pm

2 stops18h 54m

Hilton Head Island

Wed 2/18

4:15 pm-9:36 am

2 stops18h 21m

$494

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Sat 4/25

5:57 am-11:37 am

1 stop4h 40m

Myrtle Beach Intl

Fri 5/1

5:28 am-11:08 am

2 stops6h 40m

$573

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
1
2

See travel insights to South Carolina from

How to get the cheapest flight ticket from Columbia, Missouri to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Friday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $562. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $599.

Cheap Columbia, Missouri to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbia, Missouri to South Carolina

Fastest flight time

4h 53m

Direct flights

None
The fastest flight from Columbia, Missouri to South Carolina takes 4h 53m
There are no direct flights from Columbia, Missouri to South Carolina. There are no popular flight routes from Columbia, Missouri to South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Columbia Regional Airport to South Carolina?

    Prices for flights from Columbia Regional Airport to South Carolina are refreshed on a daily basis.

  • How many operators does momondo search for flights from Columbia Regional Airport to South Carolina?

  • How old do you have to be to fly from Columbia Regional Airport to South Carolina?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbia Regional Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Columbia, Missouri to South Carolina

Compare and see reviews for airlines that fly from Columbia, Missouri to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $410Free CancellationRating
7.2
11,051 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Columbia to South Carolina?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Columbia to South Carolina. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Columbia to South Carolina with flexible booking policies on momondo?

Yes. All flights to South Carolina from Columbia on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Columbia to South Carolina?

Once all potential Columbia to South Carolina flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Columbia to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Columbia to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 1/14
Wed 1/21
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to South Carolina

Popular cities in South Carolina

Popular flights according to clicks in the last 7 days on momondo
Flights to New Yorkfrom $34
Flights to Los Angelesfrom $44
Flights to Miamifrom $49
Flights to Chicagofrom $50
Flights to Orlandofrom $48
Flights to San Franciscofrom $55
Flights to Las Vegasfrom $48
Flights to Washington, D.C.from $57
Flights to Bostonfrom $52
Flights to Atlantafrom $48
Flights to Dallasfrom $56
Flights to Seattlefrom $58