Cheap flights from Colorado to South Carolina from $80

The cheapest month to fly to South Carolina from Colorado is in January. Flight prices, which tend to average around $331, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of January, then book flights to South Carolina from Colorado during October instead. Flights to South Carolina in October, while not as cheap as those in January, still average around $366.

Our data shows that Tuesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $393. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $490.

Our data shows that the cheapest Colorado to South Carolina flights are usually those with departure times at noon. Our users have found flights to South Carolina at noon for as low as $397. Try not to purchase tickets in the evening because they tend to be around $622. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Denver Intl to Greenville for the best Colorado - South Carolina flight prices

You are more likely to see cheaper flights to South Carolina from Colorado when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $410 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Colorado for as low as $321 on momondo.

There are 4 cabin classes available to choose from on Colorado to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Delta, Southwest, and American Airlines are the most popular carriers operating from Colorado to South Carolina

United Airlines, American Airlines and Southwest are the top three most popular airlines that fly to South Carolina from Colorado according to our data. United Airlines is the first choice among our users, with 36% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 6 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

As of April 2026, 11 flights take off from Colorado and land in South Carolina each day. The most common flight departure time for this route is 9:00AM, with 73% of daily flights taking off at noon.

79 flights are operational weekly from Colorado to South Carolina as of April 2026. The most popular departure day for this route is Sat, with 18% of flights per week taking off on this day.