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Cheap flights from Colorado to Florence from $485

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Colorado to Florence departing on 4/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Colorado to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:00 am - 3:50 pm
DEN
-
FLO
6h 50m
1 stop
American Airlines Logo
4:16 pm - 10:26 pm
FLO
-
DEN
8h 10m
1 stop
$516American Airlines
Sun, Apr 19 - Sun, Apr 26
American Airlines Logo
7:00 am - 3:50 pm
DEN
-
FLO
6h 50m
1 stop
American Airlines Logo
5:20 am - 1:47 pm
FLO
-
DEN
10h 27m
2 stops
$521American Airlines
Sun, Apr 19 - Sun, Apr 26
American Airlines Logo
5:30 am - 3:50 pm
DEN
-
FLO
8h 20m
2 stops
American Airlines Logo
5:20 am - 1:47 pm
FLO
-
DEN
10h 27m
2 stops
$713American Airlines
Sun, Apr 19 - Sun, Apr 26
American Airlines Logo
5:41 am - 3:50 pm
COS
-
FLO
8h 09m
2 stops
American Airlines Logo
4:16 pm - 9:27 am
FLO
-
COS
19h 11m
2 stops
$778American Airlines
Wed, Apr 8 - Sun, Apr 12
American Airlines Logo
5:41 am - 3:50 pm
COS
-
FLO
8h 09m
2 stops
American Airlines Logo
4:16 pm - 11:32 pm
FLO
-
COS
9h 16m
3 stops
$1,046American Airlines
Wed, Apr 8 - Sun, Apr 12
American Airlines Logo
9:57 am - 9:47 pm
COS
-
FLO
9h 50m
3 stops
American Airlines Logo
4:16 pm - 11:32 pm
FLO
-
COS
9h 16m
3 stops
$1,273American Airlines
Wed, Apr 8 - Sun, Apr 12

American Airlines flights from Colorado to Florence, South Carolina

Our best American Airlines deals on Colorado to Florence, South Carolina flight tickets
American Airlines
Apr 19
DEN7:00 amDenver Intl
6h 50m
1 stop
FLO3:50 pmFlorence
Apr 26
FLO4:16 pmFlorence
8h 10m
1 stop
DEN10:26 pmDenver Intl
$516
American Airlines
Apr 19
DEN7:00 amDenver Intl
6h 50m
1 stop
FLO3:50 pmFlorence
Apr 26
FLO5:20 amFlorence
10h 27m
2 stops
DEN1:47 pmDenver Intl
$521
American Airlines
Apr 19
DEN5:30 amDenver Intl
8h 20m
2 stops
FLO3:50 pmFlorence
Apr 26
FLO5:20 amFlorence
10h 27m
2 stops
DEN1:47 pmDenver Intl
$713

momondo Fare Finder

 
Customize your flight search to find flights from Colorado to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from Colorado to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Sun 4/19

7:00 am-3:50 pm

1 stop6h 50m

Florence

Sun 4/26

4:16 pm-10:26 pm

1 stop8h 10m

$516

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Sun 4/19

7:00 am-3:50 pm

1 stop6h 50m

Florence

Sun 4/26

5:20 am-1:47 pm

2 stops10h 27m

$521

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Sun 4/19

5:30 am-3:50 pm

2 stops8h 20m

Florence

Sun 4/26

5:20 am-1:47 pm

2 stops10h 27m

$713

Colorado SpringsFlorence

COS - FLO

COSFLO

Colorado Springs

Wed 4/8

5:41 am-3:50 pm

2 stops8h 09m

Florence

Sun 4/12

4:16 pm-9:27 am

2 stops19h 11m

$778

Colorado SpringsFlorence

COS - FLO

COSFLO

Colorado Springs

Wed 4/8

5:41 am-3:50 pm

2 stops8h 09m

Florence

Sun 4/12

4:16 pm-11:32 pm

3 stops9h 16m

$1,046

Colorado SpringsFlorence

COS - FLO

COSFLO

Colorado Springs

Wed 4/8

9:57 am-9:47 pm

3 stops9h 50m

Florence

Sun 4/12

4:16 pm-11:32 pm

3 stops9h 16m

$1,273
Cheapest one-way

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 4/21

7:26 am-10:42 pm

2 stops13h 16m

$485

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Mon 4/20

6:19 am-9:47 pm

2 stops13h 28m

$506
Quickest one-way

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 4/21

7:50 am-3:32 pm

1 stop5h 42m

$520

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Sun 4/19

6:19 am-9:47 pm

2 stops13h 28m

$559

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Colorado to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Colorado to Florence?

American Airlines is the most popular carrier operating from Colorado to Florence

What airlines fly to Florence, South Carolina?

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Florence, South Carolina from Colorado according to our data. American Airlines is the first choice among our users, with 44% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 6 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Colorado to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Colorado to Florence, South Carolina

Fastest flight time

6h 50m

Direct flights

None
The fastest flight from Colorado to Florence, South Carolina takes 6h 50m
There are no direct flights from Colorado to Florence, South Carolina. There are no popular flight routes from Colorado to Florence, South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Colorado to Florence Airport?

    Prices for flights from Colorado to Florence Airport are updated daily.

  • How old do you have to be to fly from Colorado to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Colorado to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Colorado to Florence?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Florence from Colorado.

Can I find flights from Colorado to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Colorado with this policy.

How can momondo help me find flights from Colorado to Florence?

momondo provides multiple filters to help you find the best flight to Florence from Colorado. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Colorado to Florence right now. Can momondo alert me if prices change?

Price alerts on flights to Florence from Colorado are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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