Cheap flights from Colorado to Florence from $559

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Colorado to Florence departing on 1/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:55 am - 5:09 pm
DEN
-
FLO
7h 14m1 stop
American Airlines Logo
5:36 pm - 9:16 pm
FLO
-
DEN
5h 40m1 stop
$559American Airlines
Tue, Jan 6 - Sat, Jan 10
American Airlines Logo
12:52 pm - 10:43 pm
DEN
-
FLO
7h 51m2 stops
American Airlines Logo
6:15 am - 12:49 pm
FLO
-
DEN
8h 34m1 stop
$564American Airlines
Tue, Jan 6 - Sat, Jan 10
American Airlines Logo
8:34 am - 10:43 pm
DEN
-
FLO
12h 09m2 stops
American Airlines Logo
6:15 am - 6:13 pm
FLO
-
DEN
13h 58m2 stops
$569American Airlines
Tue, Jan 6 - Sat, Jan 10

American Airlines flights from Colorado to Florence, South Carolina

Our best American Airlines deals on Colorado to Florence, South Carolina flight tickets
American Airlines
Jan 6
DEN7:55 amDenver Intl
7h 14m
1 stop
FLO5:09 pmFlorence
Jan 10
FLO5:36 pmFlorence
5h 40m
1 stop
DEN9:16 pmDenver Intl
American Airlines
Jan 6
DEN12:52 pmDenver Intl
7h 51m
2 stops
FLO10:43 pmFlorence
Jan 10
FLO6:15 amFlorence
8h 34m
1 stop
DEN12:49 pmDenver Intl
American Airlines
Jan 6
DEN8:34 amDenver Intl
12h 09m
2 stops
FLO10:43 pmFlorence
Jan 10
FLO6:15 amFlorence
13h 58m
2 stops
DEN6:13 pmDenver Intl

momondo Fare Finder

 
Customize your flight search to find flights from Colorado to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 22, 2025.
Use the filters below to find and compare flights from Colorado to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 1/6

7:55 am-5:09 pm

1 stop7h 14m

Florence

Sat 1/10

5:36 pm-9:16 pm

1 stop5h 40m

$559

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 1/6

12:52 pm-10:43 pm

2 stops7h 51m

Florence

Sat 1/10

6:15 am-12:49 pm

1 stop8h 34m

$564

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 1/6

8:34 am-10:43 pm

2 stops12h 09m

Florence

Sat 1/10

6:15 am-6:13 pm

2 stops13h 58m

$569

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Colorado to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Florence, South Carolina?

On average, the least expensive day to fly to Florence, South Carolina from Colorado is on a Tuesday. momondo users have found tickets for Tuesday departures for as low as $353. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Friday is the most expensive day to depart from Colorado because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $499.

What is the cheapest time of day to depart on your flight to Florence, South Carolina?

According to our data, the cheapest time of day to fly to Florence, South Carolina is in the morning. momondo users have found flights departing from Colorado to Florence, South Carolina in the morning for as low as $429. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In the afternoon is when there is more demand to fly to Florence, South Carolina, so prices are often more expensive at around $561 per ticket.

Cheap Colorado to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Colorado to Florence, South Carolina

Fastest flight time

7h 58m

Direct flights

None
The fastest flight from Colorado to Florence, South Carolina takes 7h 58m
There are no direct flights from Colorado to Florence, South Carolina. There are no popular flight routes from Colorado to Florence, South Carolina.
  • When did momondo last update prices for flights from Colorado to Florence Airport?

    Prices for flights from Colorado to Florence Airport are updated daily.

  • How old do you have to be to fly from Colorado to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Colorado to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Colorado to Florence?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Florence from Colorado.

Can I find flights from Colorado to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Colorado with this policy.

How can momondo help me find flights from Colorado to Florence?

momondo provides multiple filters to help you find the best flight to Florence from Colorado. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Colorado to Florence right now. Can momondo alert me if prices change?

Price alerts on flights to Florence from Colorado are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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1 adult
Wed 1/21
Wed 1/28

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