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Cheap flights from Colorado to Florence from $389

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Colorado to Florence departing on 7/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Colorado to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:41 am - 2:10 pm
DEN
-
FLO
5h 29m
1 stop
American Airlines Logo
5:17 am - 9:10 am
FLO
-
DEN
5h 53m
1 stop
$389American Airlines
Fri, Jul 10 - Tue, Jul 14
American Airlines Logo
3:57 pm - 11:37 pm
DEN
-
FLO
5h 40m
1 stop
American Airlines Logo
5:17 am - 5:00 pm
FLO
-
DEN
13h 43m
2 stops
$607American Airlines
Fri, Jul 10 - Tue, Jul 14
American Airlines Logo
10:44 am - 11:37 pm
COS
-
FLO
10h 53m
2 stops
American Airlines Logo
2:35 pm - 10:23 pm
FLO
-
COS
9h 48m
2 stops
$629American Airlines
Tue, Jul 7 - Sat, Jul 11
American Airlines Logo
7:12 am - 2:09 pm
DEN
-
FLO
4h 57m
1 stop
American Airlines Logo
5:22 am - 8:41 am
FLO
-
DEN
5h 19m
1 stop
$708American Airlines
Fri, Oct 23 - Mon, Oct 26
American Airlines Logo
2:17 pm - 12:03 am
DEN
-
FLO
7h 46m
1 stop
American Airlines Logo
11:07 am - 8:32 pm
FLO
-
DEN
11h 25m
2 stops
$817American Airlines
Fri, Oct 23 - Mon, Oct 26
American Airlines Logo
7:22 am - 11:37 pm
DEN
-
FLO
14h 15m
2 stops
American Airlines Logo
5:17 am - 5:19 pm
FLO
-
DEN
14h 02m
2 stops
$857American Airlines
Fri, Jul 10 - Tue, Jul 14
American Airlines Logo
7:32 am - 12:03 am
DEN
-
FLO
14h 31m
2 stops
American Airlines Logo
11:07 am - 8:32 pm
FLO
-
DEN
11h 25m
2 stops
$932American Airlines
Fri, Oct 23 - Mon, Oct 26
American Airlines Logo
10:44 am - 11:37 pm
COS
-
FLO
10h 53m
3 stops
American Airlines Logo
2:35 pm - 10:23 pm
FLO
-
COS
9h 48m
2 stops
$992American Airlines
Tue, Jul 7 - Sat, Jul 11

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American Airlines flights from Colorado to Florence, South Carolina

Our best American Airlines deals on Colorado to Florence, South Carolina flight tickets
American Airlines
Jul 10
DEN6:41 amDenver Intl
5h 29m
1 stop
FLO2:10 pmFlorence
Jul 14
FLO5:17 amFlorence
5h 53m
1 stop
DEN9:10 amDenver Intl
$389
American Airlines
Jul 10
DEN3:57 pmDenver Intl
5h 40m
1 stop
FLO11:37 pmFlorence
Jul 14
FLO5:17 amFlorence
13h 43m
2 stops
DEN5:00 pmDenver Intl
$607
American Airlines
Jun 27
DEN6:38 amDenver Intl
5h 32m
1 stop
FLO2:10 pmFlorence
Jul 1
FLO5:05 amFlorence
6h 11m
1 stop
DEN9:16 amDenver Intl
$619

momondo Fare Finder

 
Customize your flight search to find flights from Colorado to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 26, 2026.
Use the filters below to find and compare flights from Colorado to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 7/10

6:41 am-2:10 pm

1 stop5h 29m

Florence

Tue 7/14

5:17 am-9:10 am

1 stop5h 53m

$389

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 7/10

3:57 pm-11:37 pm

1 stop5h 40m

Florence

Tue 7/14

5:17 am-5:00 pm

2 stops13h 43m

$607

Colorado SpringsFlorence

COS - FLO

COSFLO

Colorado Springs

Tue 7/7

10:44 am-11:37 pm

2 stops10h 53m

Florence

Sat 7/11

2:35 pm-10:23 pm

2 stops9h 48m

$629
Quickest round-trip

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 10/23

7:12 am-2:09 pm

1 stop4h 57m

Florence

Mon 10/26

5:22 am-8:41 am

1 stop5h 19m

$708

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 10/23

2:17 pm-12:03 am

1 stop7h 46m

Florence

Mon 10/26

11:07 am-8:32 pm

2 stops11h 25m

$817

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 7/10

7:22 am-11:37 pm

2 stops14h 15m

Florence

Tue 7/14

5:17 am-5:19 pm

2 stops14h 02m

$857

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 10/23

7:32 am-12:03 am

2 stops14h 31m

Florence

Mon 10/26

11:07 am-8:32 pm

2 stops11h 25m

$932

Colorado SpringsFlorence

COS - FLO

COSFLO

Colorado Springs

Tue 7/7

10:44 am-11:37 pm

3 stops10h 53m

Florence

Sat 7/11

2:35 pm-10:23 pm

2 stops9h 48m

$992
Cheapest one-way

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 7/24

9:08 am-11:37 pm

2 stops12h 29m

$425

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 7/24

11:59 pm-11:37 pm

1 stop21h 38m

$565

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Colorado to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Colorado to Florence?

American Airlines is the most popular carrier operating from Colorado to Florence

What airlines fly to Florence, South Carolina?

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Florence, South Carolina from Colorado according to our data. American Airlines is the first choice among our users, with 44% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 6 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Colorado to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Colorado to Florence, South Carolina

Fastest flight time

4h 57m

Direct flights

None
The fastest flight from Colorado to Florence, South Carolina takes 4h 57m
There are no direct flights from Colorado to Florence, South Carolina. There are no popular flight routes from Colorado to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Colorado to Florence, South Carolina

  • When did momondo last update prices for flights from Colorado to Florence Airport?

    Prices for flights from Colorado to Florence Airport are updated daily.

  • How old do you have to be to fly from Colorado to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Colorado to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Colorado to Florence?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Florence from Colorado.

Can I find flights from Colorado to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Colorado with this policy.

How can momondo help me find flights from Colorado to Florence?

momondo provides multiple filters to help you find the best flight to Florence from Colorado. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Colorado to Florence right now. Can momondo alert me if prices change?

Price alerts on flights to Florence from Colorado are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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