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Cheap flights from Colorado to Florence from $429

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Colorado to Florence departing on 9/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Colorado to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
11:59 pm - 10:21 am
DEN
-
FLO
8h 22m
1 stop
American Airlines Logo
11:20 am - 2:30 pm
FLO
-
DEN
5h 10m
1 stop
$429American Airlines
Thu, Sep 10 - Mon, Sep 14
American Airlines Logo
6:38 am - 2:10 pm
DEN
-
FLO
5h 32m
1 stop
American Airlines Logo
2:35 pm - 11:55 pm
FLO
-
DEN
11h 20m
2 stops
$434American Airlines
Wed, Jun 3 - Tue, Jun 9
American Airlines Logo
7:11 am - 3:40 pm
DEN
-
FLO
6h 29m
1 stop
American Airlines Logo
6:31 pm - 9:47 pm
FLO
-
DEN
5h 16m
1 stop
$534American Airlines
Fri, Sep 25 - Wed, Sep 30
American Airlines Logo
4:27 pm - 12:13 am
DEN
-
FLO
5h 46m
1 stop
American Airlines Logo
11:20 am - 7:39 pm
FLO
-
DEN
10h 19m
2 stops
$539American Airlines
Fri, Sep 18 - Wed, Sep 23
American Airlines Logo
6:30 am - 2:12 pm
DEN
-
FLO
5h 42m
1 stop
American Airlines Logo
5:31 am - 8:38 am
FLO
-
DEN
5h 07m
1 stop
$544American Airlines
Sat, Sep 5 - Wed, Sep 9
American Airlines Logo
6:38 am - 2:10 pm
DEN
-
FLO
5h 32m
1 stop
American Airlines Logo
2:35 pm - 11:55 pm
FLO
-
DEN
11h 20m
2 stops
$546American Airlines
Tue, Jun 2 - Mon, Jun 8
American Airlines Logo
6:30 am - 2:12 pm
DEN
-
FLO
5h 42m
1 stop
American Airlines Logo
5:31 am - 3:33 pm
FLO
-
DEN
12h 02m
2 stops
$549American Airlines
Sat, Sep 5 - Thu, Sep 10
American Airlines Logo
10:38 am - 10:00 pm
DEN
-
FLO
9h 22m
2 stops
American Airlines Logo
2:35 pm - 11:55 pm
FLO
-
DEN
11h 20m
2 stops
$552American Airlines
Tue, Jun 2 - Mon, Jun 8
American Airlines Logo
11:59 pm - 11:37 pm
DEN
-
FLO
21h 38m
1 stop
American Airlines Logo
2:37 pm - 8:09 pm
FLO
-
DEN
7h 32m
1 stop
$553American Airlines
Sun, Jul 26 - Sat, Aug 8
American Airlines Logo
10:38 am - 10:00 pm
DEN
-
FLO
9h 22m
2 stops
American Airlines Logo
2:35 pm - 11:55 pm
FLO
-
DEN
11h 20m
2 stops
$554American Airlines
Wed, Jun 3 - Tue, Jun 9

American Airlines flights from Colorado to Florence, South Carolina

Our best American Airlines deals on Colorado to Florence, South Carolina flight tickets
American Airlines
Sep 10
DEN11:59 pmDenver Intl
8h 22m
1 stop
FLO10:21 amFlorence
Sep 14
FLO11:20 amFlorence
5h 10m
1 stop
DEN2:30 pmDenver Intl
$429
American Airlines
Jun 3
DEN6:38 amDenver Intl
5h 32m
1 stop
FLO2:10 pmFlorence
Jun 9
FLO2:35 pmFlorence
11h 20m
2 stops
DEN11:55 pmDenver Intl
$434
American Airlines
Sep 25
DEN7:11 amDenver Intl
6h 29m
1 stop
FLO3:40 pmFlorence
Sep 30
FLO6:31 pmFlorence
5h 16m
1 stop
DEN9:47 pmDenver Intl
$534

momondo Fare Finder

 
Customize your flight search to find flights from Colorado to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 11, 2026.
Use the filters below to find and compare flights from Colorado to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Thu 9/10

11:59 pm-10:21 am

1 stop8h 22m

Florence

Mon 9/14

11:20 am-2:30 pm

1 stop5h 10m

$429

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Wed 6/3

6:38 am-2:10 pm

1 stop5h 32m

Florence

Tue 6/9

2:35 pm-11:55 pm

2 stops11h 20m

$434

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 9/25

7:11 am-3:40 pm

1 stop6h 29m

Florence

Wed 9/30

6:31 pm-9:47 pm

1 stop5h 16m

$534

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 9/18

4:27 pm-12:13 am

1 stop5h 46m

Florence

Wed 9/23

11:20 am-7:39 pm

2 stops10h 19m

$539
Quickest round-trip

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Sat 9/5

6:30 am-2:12 pm

1 stop5h 42m

Florence

Wed 9/9

5:31 am-8:38 am

1 stop5h 07m

$544

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 6/2

6:38 am-2:10 pm

1 stop5h 32m

Florence

Mon 6/8

2:35 pm-11:55 pm

2 stops11h 20m

$546

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Sat 9/5

6:30 am-2:12 pm

1 stop5h 42m

Florence

Thu 9/10

5:31 am-3:33 pm

2 stops12h 02m

$549

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 6/2

10:38 am-10:00 pm

2 stops9h 22m

Florence

Mon 6/8

2:35 pm-11:55 pm

2 stops11h 20m

$552

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Sun 7/26

11:59 pm-11:37 pm

1 stop21h 38m

Florence

Sat 8/8

2:37 pm-8:09 pm

1 stop7h 32m

$553

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Wed 6/3

10:38 am-10:00 pm

2 stops9h 22m

Florence

Tue 6/9

2:35 pm-11:55 pm

2 stops11h 20m

$554

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Colorado to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Colorado to Florence?

American Airlines is the most popular carrier operating from Colorado to Florence

What airlines fly to Florence, South Carolina?

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Florence, South Carolina from Colorado according to our data. American Airlines is the first choice among our users, with 44% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 6 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Colorado to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Colorado to Florence, South Carolina

Fastest flight time

6h 03m

Direct flights

None
The fastest flight from Colorado to Florence, South Carolina takes 6h 03m
There are no direct flights from Colorado to Florence, South Carolina. There are no popular flight routes from Colorado to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Colorado to Florence, South Carolina

  • When did momondo last update prices for flights from Colorado to Florence Airport?

    Prices for flights from Colorado to Florence Airport are updated daily.

  • How old do you have to be to fly from Colorado to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Colorado to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington
Bennettsville
Lake City

Why use momondo?

Why should I use momondo to find a flight deal from Colorado to Florence?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Florence from Colorado.

Can I find flights from Colorado to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Colorado with this policy.

How can momondo help me find flights from Colorado to Florence?

momondo provides multiple filters to help you find the best flight to Florence from Colorado. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Colorado to Florence right now. Can momondo alert me if prices change?

Price alerts on flights to Florence from Colorado are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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