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Cheap flights from Colorado to Florence from $339

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Colorado to Florence departing on 10/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Colorado to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:20 pm - 11:12 pmDEN  Denver Intl-FLO Florence
7h 52m1 stop Charlotte Douglas
American Airlines Logo
6:30 am - 12:30 pmFLO  Florence-DEN Denver Intl
8h 00m1 stop Charlotte Douglas
$339American Airlines
Tue, Oct 13 - Tue, Oct 20
American Airlines Logo
1:20 pm - 10:59 pmDEN  Denver Intl-FLO Florence
7h 39m1 stop Charlotte Douglas
American Airlines Logo
3:22 pm - 7:19 pmFLO  Florence-DEN Denver Intl
5h 57m1 stop Charlotte Douglas
$399American Airlines
Tue, Aug 25 - Sat, Aug 29
American Airlines Logo
1:20 pm - 11:12 pmDEN  Denver Intl-FLO Florence
7h 52m1 stop Charlotte Douglas
American Airlines Logo
6:30 am - 6:58 pmFLO  Florence-DEN Denver Intl
14h 28m2 stops Charlotte Douglas Dallas/Fort Worth
$485American Airlines
Tue, Oct 13 - Tue, Oct 20
American Airlines Logo
8:00 am - 11:12 pmDEN  Denver Intl-FLO Florence
13h 12m2 stops Chicago O'Hare Intl Charlotte Douglas
American Airlines Logo
6:30 am - 5:19 pmFLO  Florence-DEN Denver Intl
12h 49m2 stops Charlotte Douglas Chicago O'Hare Intl
$571American Airlines
Tue, Oct 13 - Tue, Oct 20
American Airlines Logo
6:15 am - 2:56 pmDEN  Denver Intl-FLO Florence
6h 41m1 stop Charlotte Douglas
American Airlines Logo
6:22 am - 7:38 pmFLO  Florence-DEN Denver Intl
15h 16m2 stops Charlotte Douglas Dallas/Fort Worth
$621American Airlines
Tue, Aug 25 - Sat, Aug 29
American Airlines Logo
10:39 am - 11:57 pmDEN  Denver Intl-FLO Florence
11h 18m2 stops Dallas/Fort Worth Charlotte Douglas
American Airlines Logo
5:09 am - 9:16 amFLO  Florence-DEN Denver Intl
6h 07m1 stop Charlotte Douglas
$631American Airlines
Fri, Oct 9 - Sun, Oct 18
American Airlines Logo
4:07 pm - 11:57 pmDEN  Denver Intl-FLO Florence
5h 50m1 stop Charlotte Douglas
American Airlines Logo
5:09 am - 9:16 amFLO  Florence-DEN Denver Intl
6h 07m1 stop Charlotte Douglas
$713American Airlines
Fri, Oct 9 - Sun, Oct 18
American Airlines Logo
9:16 am - 10:59 pmDEN  Denver Intl-FLO Florence
11h 43m2 stops Dallas/Fort Worth Charlotte Douglas
American Airlines Logo
3:22 pm - 10:15 pmFLO  Florence-DEN Denver Intl
8h 53m2 stops Charlotte Douglas Dallas/Fort Worth
$811American Airlines
Tue, Aug 25 - Sat, Aug 29
American Airlines Logo
8:00 am - 11:57 pmDEN  Denver Intl-FLO Florence
13h 57m2 stops Chicago O'Hare Intl Charlotte Douglas
American Airlines Logo
2:34 pm - 12:36 amFLO  Florence-DEN Denver Intl
12h 02m2 stops Charlotte Douglas Chicago O'Hare Intl
$902American Airlines
Fri, Oct 9 - Sun, Oct 18

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American Airlines flights from Colorado to Florence, South Carolina

Our best American Airlines deals on Colorado to Florence, South Carolina flight tickets
American Airlines
Oct 13
DEN1:20 pmDenver Intl
7h 52m
1 stop
FLO11:12 pmFlorence
Oct 20
FLO6:30 amFlorence
8h 00m
1 stop
DEN12:30 pmDenver Intl
$339
American Airlines
Aug 25
DEN1:20 pmDenver Intl
7h 39m
1 stop
FLO10:59 pmFlorence
Aug 29
FLO3:22 pmFlorence
5h 57m
1 stop
DEN7:19 pmDenver Intl
$399
American Airlines
Oct 13
DEN1:20 pmDenver Intl
7h 52m
1 stop
FLO11:12 pmFlorence
Oct 20
FLO6:30 amFlorence
14h 28m
2 stops
DEN6:58 pmDenver Intl
$485

momondo Fare Finder

 
Customize your flight search to find flights from Colorado to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 10, 2026.
Use the filters below to find and compare flights from Colorado to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DenverFlorence

DEN Denver Intl - FLO Florence

DENFLO

Denver Intl

Tue 10/13

1:20 pm-11:12 pm

1 stop7h 52m

Florence

Tue 10/20

6:30 am-12:30 pm

1 stop8h 00m

$339

DenverFlorence

DEN Denver Intl - FLO Florence

DENFLO

Denver Intl

Tue 8/25

1:20 pm-10:59 pm

1 stop7h 39m

Florence

Sat 8/29

3:22 pm-7:19 pm

1 stop5h 57m

$399

DenverFlorence

DEN Denver Intl - FLO Florence

DENFLO

Denver Intl

Tue 10/13

1:20 pm-11:12 pm

1 stop7h 52m

Florence

Tue 10/20

6:30 am-6:58 pm

2 stops14h 28m

$485

DenverFlorence

DEN Denver Intl - FLO Florence

DENFLO

Denver Intl

Tue 10/13

8:00 am-11:12 pm

2 stops13h 12m

Florence

Tue 10/20

6:30 am-5:19 pm

2 stops12h 49m

$571

DenverFlorence

DEN Denver Intl - FLO Florence

DENFLO

Denver Intl

Tue 8/25

6:15 am-2:56 pm

1 stop6h 41m

Florence

Sat 8/29

6:22 am-7:38 pm

2 stops15h 16m

$621

DenverFlorence

DEN Denver Intl - FLO Florence

DENFLO

Denver Intl

Fri 10/9

10:39 am-11:57 pm

2 stops11h 18m

Florence

Sun 10/18

5:09 am-9:16 am

1 stop6h 07m

$631
Quickest round-trip

DenverFlorence

DEN Denver Intl - FLO Florence

DENFLO

Denver Intl

Fri 10/9

4:07 pm-11:57 pm

1 stop5h 50m

Florence

Sun 10/18

5:09 am-9:16 am

1 stop6h 07m

$713

DenverFlorence

DEN Denver Intl - FLO Florence

DENFLO

Denver Intl

Tue 8/25

9:16 am-10:59 pm

2 stops11h 43m

Florence

Sat 8/29

3:22 pm-10:15 pm

2 stops8h 53m

$811

DenverFlorence

DEN Denver Intl - FLO Florence

DENFLO

Denver Intl

Fri 10/9

8:00 am-11:57 pm

2 stops13h 57m

Florence

Sun 10/18

2:34 pm-12:36 am

2 stops12h 02m

$902
Cheapest one-way

DenverFlorence

DEN Denver Intl - FLO Florence

DENFLO

Denver Intl

Wed 10/7

8:00 am-11:57 pm

2 stops13h 57m

$348

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 11 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Colorado to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Colorado to Florence?

American Airlines is the most popular carrier operating from Colorado to Florence

What airlines fly to Florence, South Carolina?

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Florence, South Carolina from Colorado according to our data. American Airlines is the first choice among our users, with 43% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 6 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Colorado to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Colorado to Florence, South Carolina

Fastest flight time

10h 53m

Direct flights

None
The fastest flight from Colorado to Florence, South Carolina takes 10h 53m
There are no direct flights from Colorado to Florence, South Carolina. There are no popular flight routes from Colorado to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Colorado to Florence, South Carolina

  • When did momondo last update prices for flights from Colorado to Florence Airport?

    Prices for flights from Colorado to Florence Airport are updated daily.

  • How old do you have to be to fly from Colorado to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Colorado to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Colorado to Florence?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Florence from Colorado.

Can I find flights from Colorado to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Colorado with this policy.

How can momondo help me find flights from Colorado to Florence?

momondo provides multiple filters to help you find the best flight to Florence from Colorado. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Colorado to Florence right now. Can momondo alert me if prices change?

Price alerts on flights to Florence from Colorado are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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