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Cheap flights from Cleveland to Des Moines from $149

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Cleveland to Des Moines departing on 12/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Cleveland to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
11:00 am - 2:27 pm
CLE
-
DSM
4h 27m1 stop
United Airlines Logo
3:24 pm - 10:15 pm
DSM
-
CLE
5h 51m1 stop
$247United Airlines
Fri, Feb 20 - Mon, Feb 23
United Airlines Logo
6:25 am - 2:27 pm
CLE
-
DSM
9h 02m2 stops
United Airlines Logo
3:24 pm - 10:15 pm
DSM
-
CLE
5h 51m1 stop
$252United Airlines
Fri, Feb 20 - Mon, Feb 23
American Airlines Logo
8:00 am - 1:21 pm
CLE
-
DSM
6h 21m1 stop
American Airlines Logo
4:00 pm - 10:43 pm
DSM
-
CLE
5h 43m1 stop
$255American Airlines
Wed, Dec 31 - Wed, Jan 7
American Airlines Logo
5:00 am - 12:24 pm
CLE
-
DSM
8h 24m1 stop
American Airlines Logo
7:00 am - 3:36 pm
DSM
-
CLE
7h 36m2 stops
$260American Airlines
Wed, Dec 31 - Wed, Jan 7
American Airlines Logo
7:00 am - 2:52 pm
CLE
-
DSM
8h 52m2 stops
American Airlines Logo
7:00 am - 3:36 pm
DSM
-
CLE
7h 36m2 stops
$265American Airlines
Wed, Dec 31 - Wed, Jan 7
United Airlines Logo
7:20 am - 10:55 am
CLE
-
DSM
4h 35m1 stop
United Airlines Logo
7:50 am - 1:20 pm
DSM
-
CLE
4h 30m1 stop
$268United Airlines
Wed, Jan 7 - Sat, Jan 10
United Airlines Logo
4:20 pm - 11:44 pm
CLE
-
DSM
8h 24m1 stop
United Airlines Logo
3:35 pm - 11:44 pm
DSM
-
CLE
7h 09m2 stops
$273United Airlines
Wed, Jan 7 - Sat, Jan 10
United Airlines Logo
12:23 pm - 9:50 pm
CLE
-
DSM
10h 27m2 stops
United Airlines Logo
5:30 am - 4:51 pm
DSM
-
CLE
10h 21m2 stops
$278United Airlines
Wed, Jan 7 - Sat, Jan 10
United Airlines Logo
6:25 am - 2:27 pm
CLE
-
DSM
9h 02m2 stops
United Airlines Logo
3:24 pm - 11:44 pm
DSM
-
CLE
7h 20m2 stops
$281United Airlines
Fri, Feb 20 - Mon, Feb 23
Delta Logo
3:52 pm - 8:54 pm
CLE
-
DSM
6h 02m1 stop
Delta Logo
10:59 am - 4:59 pm
DSM
-
CLE
5h 00m1 stop
$311Delta
Mon, Jan 5 - Tue, Jan 6

American Airlines flights from Cleveland to Des Moines

Our best American Airlines deals on Cleveland to Des Moines flight tickets
American Airlines
Dec 31
CLE8:00 amCleveland Hopkins Intl
6h 21m
1 stop
DSM1:21 pmDes Moines
Jan 7
DSM4:00 pmDes Moines
5h 43m
1 stop
CLE10:43 pmCleveland Hopkins Intl
$255
Find similar
American Airlines
Dec 31
CLE5:00 amCleveland Hopkins Intl
8h 24m
1 stop
DSM12:24 pmDes Moines
Jan 7
DSM7:00 amDes Moines
7h 36m
2 stops
CLE3:36 pmCleveland Hopkins Intl
$260
Find similar
American Airlines
Dec 31
CLE7:00 amCleveland Hopkins Intl
8h 52m
2 stops
DSM2:52 pmDes Moines
Jan 7
DSM7:00 amDes Moines
7h 36m
2 stops
CLE3:36 pmCleveland Hopkins Intl
$265
Find similar

Delta flights from Cleveland to Des Moines

Our best Delta deals on Cleveland to Des Moines flight tickets
Delta
Jan 5
CLE3:52 pmCleveland Hopkins Intl
6h 02m
1 stop
DSM8:54 pmDes Moines
Jan 6
DSM10:59 amDes Moines
5h 00m
1 stop
CLE4:59 pmCleveland Hopkins Intl
$311
Find similar
Delta
Jan 5
CLE3:52 pmCleveland Hopkins Intl
6h 02m
1 stop
DSM8:54 pmDes Moines
Jan 6
DSM4:21 pmDes Moines
5h 33m
1 stop
CLE10:54 pmCleveland Hopkins Intl
$332
Find similar
Delta
Dec 21
CLE6:29 amCleveland Hopkins Intl
4h 20m
1 stop
DSM9:49 amDes Moines
Dec 25
DSM6:15 amDes Moines
4h 08m
1 stop
CLE11:23 amCleveland Hopkins Intl
$351
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Cleveland to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 7, 2025.
Use the filters below to find and compare flights from Cleveland to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Fri 2/20

11:00 am-2:27 pm

1 stop4h 27m

Des Moines

Mon 2/23

3:24 pm-10:15 pm

1 stop5h 51m

$247

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Fri 2/20

6:25 am-2:27 pm

2 stops9h 02m

Des Moines

Mon 2/23

3:24 pm-10:15 pm

1 stop5h 51m

$252

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Wed 12/31

8:00 am-1:21 pm

1 stop6h 21m

Des Moines

Wed 1/7

4:00 pm-10:43 pm

1 stop5h 43m

$255

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Wed 12/31

5:00 am-12:24 pm

1 stop8h 24m

Des Moines

Wed 1/7

7:00 am-3:36 pm

2 stops7h 36m

$260

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Wed 12/31

7:00 am-2:52 pm

2 stops8h 52m

Des Moines

Wed 1/7

7:00 am-3:36 pm

2 stops7h 36m

$265

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Wed 1/7

7:20 am-10:55 am

1 stop4h 35m

Des Moines

Sat 1/10

7:50 am-1:20 pm

1 stop4h 30m

$268

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Wed 1/7

4:20 pm-11:44 pm

1 stop8h 24m

Des Moines

Sat 1/10

3:35 pm-11:44 pm

2 stops7h 09m

$273

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Wed 1/7

12:23 pm-9:50 pm

2 stops10h 27m

Des Moines

Sat 1/10

5:30 am-4:51 pm

2 stops10h 21m

$278

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Fri 2/20

6:25 am-2:27 pm

2 stops9h 02m

Des Moines

Mon 2/23

3:24 pm-11:44 pm

2 stops7h 20m

$281

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Mon 1/5

3:52 pm-8:54 pm

1 stop6h 02m

Des Moines

Tue 1/6

10:59 am-4:59 pm

1 stop5h 00m

$311

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Cleveland to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Cleveland to Des Moines is on a Tuesday. Travelers who choose to depart for Des Moines on a Tuesday will often find tickets for as low as $364. Flights from Cleveland to Des Moines on a Sunday will generally be more expensive and average around $622. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the evening. momondo users have found flights departing from Cleveland to Des Moines in the evening for as low as $350. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets at noon because they tend to be around $477. Of course, these prices can vary depending on the time of year and what airport you fly to.

How have Cleveland to Des Moines flight prices changed over time?

As of December 2025, prices for Cleveland to Des Moines flights are approximately 21% more expensive when compared to flights at the same time last year.

When to book flights from Cleveland to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Cleveland to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Cleveland to Des Moines (CLE to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Cleveland to Des Moines

Fastest flight time

3h 50m

Direct flights

None
The fastest flight from Cleveland to Des Moines takes 3h 50m
There are no direct flights from Cleveland to Des Moines. There are no popular flight routes from Cleveland to Des Moines.
Search flight deals

  • How far is Cleveland Hopkins Intl to Des Moines by plane?

    The distance between Cleveland Hopkins Intl and Des Moines is about 616.3 mi. In terms of flight time, this usually takes a little over 4h 11m.

  • When did momondo last update prices for flights from Cleveland Hopkins Intl Airport to Des Moines Airport?

    Prices for flights from Cleveland Hopkins Intl Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Cleveland Hopkins Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Cleveland Hopkins Intl Airport to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Cleveland Hopkins Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Cleveland to Des Moines?

Best airlines flying from Cleveland to Des Moines

Compare and see reviews for airlines that fly from Cleveland to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $271Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights
SouthwestPriceFrom $286Free CancellationRating
8.0
4,252 reviews
Search Southwest flights
United AirlinesPriceFrom $286Free CancellationRating
7.4
9,076 reviews
Search United Airlines flights
DeltaPriceFrom $296Free CancellationRating
7.9
8,013 reviews
Search Delta flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Cleveland to Des Moines?

Finding the right flight to Des Moines from Cleveland is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from Cleveland to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Cleveland on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Cleveland to Des Moines?

Once all potential Cleveland to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Cleveland to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Cleveland to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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