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Cheap flights from Cleveland to Des Moines from $139

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Cleveland to Des Moines departing on 10/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Cleveland to Des Moines

Cheap round-trip flights

Frontier Logo
4:15 pm - 1:52 pmCLE-DSM
22h 37m2 stops
Frontier Logo
2:37 pm - 1:52 amDSM-CLE
10h 15m1 stop
$188Frontier
Find Deal
Tue, Oct 14 - Thu, Oct 16
Frontier Logo
4:15 pm - 1:52 pmCLE-DSM
22h 37m2 stops
Frontier Logo
2:37 pm - 11:42 amDSM-CLE
20h 05m2 stops
$241Frontier
Find Deal
Tue, Oct 14 - Thu, Oct 16
Delta Logo
5:20 am - 9:20 amCLE-DSM
5h 00m1 stop
Delta Logo
10:00 am - 3:20 pmDSM-CLE
4h 20m1 stop
$287Delta
Find Deal
Tue, Oct 14 - Thu, Oct 16
Delta Logo
10:57 am - 5:12 pmCLE-DSM
7h 15m1 stop
Delta Logo
5:52 pm - 11:57 pmDSM-CLE
5h 05m1 stop
$322Delta
Find Deal
Wed, Nov 12 - Fri, Nov 21
American Airlines Logo
3:42 pm - 8:11 pmCLE-DSM
5h 29m1 stop
American Airlines Logo
6:22 pm - 12:25 amDSM-CLE
5h 03m1 stop
$332American Airlines
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Thu, Oct 23 - Sun, Oct 26
American Airlines Logo
4:14 pm - 9:13 pmCLE-DSM
5h 59m1 stop
American Airlines Logo
6:22 pm - 12:25 amDSM-CLE
5h 03m1 stop
$357American Airlines
Find Deal
Fri, Oct 24 - Sun, Oct 26
Southwest Logo
1:10 pm - 9:35 pmCLE-DSM
9h 25m2 stops
Southwest Logo
5:45 am - 3:40 pmDSM-CLE
8h 55m2 stops
$362Southwest
Find Deal
Wed, Nov 12 - Fri, Nov 21
Southwest Logo
6:35 am - 11:00 amCLE-DSM
5h 25m2 stops
Southwest Logo
6:00 am - 5:15 pmDSM-CLE
10h 15m2 stops
$393Southwest
Find Deal
Thu, Oct 23 - Sun, Oct 26
United Airlines Logo
6:00 am - 2:23 pmCLE-DSM
9h 23m2 stops
United Airlines Logo
6:36 pm - 11:58 pmDSM-CLE
4h 22m1 stop
$462United Airlines
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Fri, Oct 17 - Sun, Oct 19
United Airlines Logo
6:00 am - 2:23 pmCLE-DSM
9h 23m2 stops
United Airlines Logo
6:36 pm - 11:58 pmDSM-CLE
4h 22m1 stop
$477United Airlines
Find Deal
Fri, Oct 17 - Sun, Oct 19

United Airlines flights from Cleveland to Des Moines

Our best United Airlines deals on Cleveland to Des Moines flight tickets
United Airlines
Oct 17
CLE6:00 amCleveland Hopkins Intl
9h 23m
2 stops
DSM2:23 pmDes Moines
Oct 19
DSM6:36 pmDes Moines
4h 22m
1 stop
CLE11:58 pmCleveland Hopkins Intl
$462
Find similar
United Airlines
Oct 17
CLE6:00 amCleveland Hopkins Intl
9h 23m
2 stops
DSM2:23 pmDes Moines
Oct 19
DSM6:36 pmDes Moines
4h 22m
1 stop
CLE11:58 pmCleveland Hopkins Intl
$477
Find similar
United Airlines
Oct 1
CLE2:21 pmCleveland Hopkins Intl
4h 03m
1 stop
DSM5:24 pmDes Moines
Oct 7
DSM3:25 pmDes Moines
4h 00m
1 stop
CLE8:25 pmCleveland Hopkins Intl
$487
Find similar

Delta flights from Cleveland to Des Moines

Our best Delta deals on Cleveland to Des Moines flight tickets
Delta
Oct 14
CLE5:20 amCleveland Hopkins Intl
5h 00m
1 stop
DSM9:20 amDes Moines
Oct 16
DSM10:00 amDes Moines
4h 20m
1 stop
CLE3:20 pmCleveland Hopkins Intl
$287
Find similar
Delta
Nov 12
CLE10:57 amCleveland Hopkins Intl
7h 15m
1 stop
DSM5:12 pmDes Moines
Nov 21
DSM5:52 pmDes Moines
5h 05m
1 stop
CLE11:57 pmCleveland Hopkins Intl
$322
Find similar
Delta
Oct 8
CLE4:00 pmCleveland Hopkins Intl
5h 35m
1 stop
DSM8:35 pmDes Moines
Oct 12
DSM5:56 pmDes Moines
4h 53m
1 stop
CLE11:49 pmCleveland Hopkins Intl
$427
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Cleveland to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 23, 2025.
Use the filters below to find and compare flights from Cleveland to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Tue 10/14

4:15 pm-1:52 pm

2 stops22h 37m

Des Moines

Thu 10/16

2:37 pm-1:52 am

1 stop10h 15m

$188

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Tue 10/14

4:15 pm-1:52 pm

2 stops22h 37m

Des Moines

Thu 10/16

2:37 pm-11:42 am

2 stops20h 05m

$241

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Tue 10/14

5:20 am-9:20 am

1 stop5h 00m

Des Moines

Thu 10/16

10:00 am-3:20 pm

1 stop4h 20m

$287

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Wed 11/12

10:57 am-5:12 pm

1 stop7h 15m

Des Moines

Fri 11/21

5:52 pm-11:57 pm

1 stop5h 05m

$322

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Thu 10/23

3:42 pm-8:11 pm

1 stop5h 29m

Des Moines

Sun 10/26

6:22 pm-12:25 am

1 stop5h 03m

$332

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Fri 10/24

4:14 pm-9:13 pm

1 stop5h 59m

Des Moines

Sun 10/26

6:22 pm-12:25 am

1 stop5h 03m

$357

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Wed 11/12

1:10 pm-9:35 pm

2 stops9h 25m

Des Moines

Fri 11/21

5:45 am-3:40 pm

2 stops8h 55m

$362

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Thu 10/23

6:35 am-11:00 am

2 stops5h 25m

Des Moines

Sun 10/26

6:00 am-5:15 pm

2 stops10h 15m

$393

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Fri 10/17

6:00 am-2:23 pm

2 stops9h 23m

Des Moines

Sun 10/19

6:36 pm-11:58 pm

1 stop4h 22m

$462

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Fri 10/17

6:00 am-2:23 pm

2 stops9h 23m

Des Moines

Sun 10/19

6:36 pm-11:58 pm

1 stop4h 22m

$477

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Cleveland to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Cleveland to Des Moines is on a Tuesday. Travelers who choose to depart for Des Moines on a Tuesday will often find tickets for as low as $364. Flights from Cleveland to Des Moines on a Sunday will generally be more expensive and average around $622. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the evening. momondo users have found flights departing from Cleveland to Des Moines in the evening for as low as $350. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets at noon because they tend to be around $477. Of course, these prices can vary depending on the time of year and what airport you fly to.

How have Cleveland to Des Moines flight prices changed over time?

As of September 2025, prices for Cleveland to Des Moines flights are approximately 28% cheaper when compared to flights at the same time last year.

When to book flights from Cleveland to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Cleveland to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Cleveland to Des Moines (CLE to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Cleveland to Des Moines

Direct flights

None
There are no direct flights from Cleveland to Des Moines. There are no popular flight routes from Cleveland to Des Moines.
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  • How far is Cleveland Hopkins Intl to Des Moines by plane?

    The distance between Cleveland Hopkins Intl and Des Moines is about 616.3 mi. In terms of flight time, this usually takes a little over 4h 23m.

  • When did momondo last update prices for flights from Cleveland Hopkins Intl Airport to Des Moines Airport?

    Prices for flights from Cleveland Hopkins Intl Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Cleveland Hopkins Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Cleveland Hopkins Intl Airport to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Cleveland Hopkins Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Cleveland to Des Moines?

Best airlines flying from Cleveland to Des Moines

Compare and see reviews for airlines that fly from Cleveland to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $271Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $280Free CancellationRating
7.9
7,974 reviews
Search Delta flights
United AirlinesPriceFrom $286Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights
SouthwestPriceFrom $291Free CancellationRating
8.0
4,244 reviews
Search Southwest flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Newton
Osceola
Johnston
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Cleveland to Des Moines?

Finding the right flight to Des Moines from Cleveland is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from Cleveland to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Cleveland on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Cleveland to Des Moines?

Once all potential Cleveland to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Cleveland to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Cleveland to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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