Cheap flights from Chicago to South Carolina from $122

The cheapest month to fly to South Carolina from Chicago is in September. Flight prices, which tend to average around $362, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Chicago during August instead. Flights to South Carolina in August, while not as cheap as those in September, still average around $364.

Our data shows that Wednesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $345. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $408.

Our data shows that the cheapest Chicago to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $373. Try not to purchase tickets at noon because they tend to be around $402. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Chicago O'Hare Intl to Charleston for the best Chicago - South Carolina flight prices

You are more likely to see cheaper flights to South Carolina from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $394 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Chicago for as low as $334 on momondo.

There are 4 cabin classes available to choose from on Chicago to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

United Airlines, Delta, and American Airlines are the most popular carriers operating from Chicago to South Carolina

American Airlines, United Airlines and Southwest are the top three most popular airlines that fly to South Carolina from Chicago according to our data. American Airlines is the first choice among our users, with 48% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

As of November 2026, there are 51 flights per day flying from Chicago to South Carolina. The most common time of day flights depart is 5:00PM, with 43% of flights taking off in the afternoon.

359 flights are operational weekly from Chicago to South Carolina as of November 2026. The most popular departure day for this route is Mon, with 16% of flights per week taking off on this day.