Cheap flights from Chicago to South Carolina from $122

The cheapest month to fly to South Carolina from Chicago is in January. Flight prices, which tend to average around $348, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of January, then book flights to South Carolina from Chicago during September instead. Flights to South Carolina in September, while not as cheap as those in January, still average around $351.

Our data shows that Tuesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $353. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $409.

Our data shows that the cheapest Chicago to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $376. Try not to purchase tickets in the afternoon because they tend to be around $390. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Chicago O'Hare Intl to Charleston for the best Chicago - South Carolina flight prices

You are more likely to see cheaper flights to South Carolina from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $387 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Chicago for as low as $340 on momondo.

There are 4 cabin classes available to choose from on Chicago to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

United Airlines, Southwest, and Frontier are the most popular carriers operating from Chicago to South Carolina

United Airlines, American Airlines and Southwest are the top three most popular airlines that fly to South Carolina from Chicago according to our data. United Airlines is the first choice among our users, with 49% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

As of September 2026, there are 19 flights per day flying from Chicago to South Carolina. The most common time of day flights depart is 10:00AM, with 50% of flights taking off at noon.

136 flights are operational weekly from Chicago to South Carolina as of September 2026. The most popular departure day for this route is Mon, with 38% of flights per week taking off on this day.