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Cheap flights from Chicago to Des Moines from $78

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Des Moines departing on 9/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Chicago to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:30 am - 10:44 amORD  Chicago O'Hare Intl-DSM Des Moines
28h 14m1 stop Denver Intl
Frontier Logo
11:29 am - 12:23 amDSM  Des Moines-ORD Chicago O'Hare Intl
12h 54m1 stop Denver Intl
$181Frontier
Wed, Sep 9 - Thu, Sep 24
Multiple Airlines Logo
7:25 am - 7:57 pmORD  Chicago O'Hare Intl-DSM Des Moines
12h 32m1 stop Philadelphia
Multiple Airlines Logo
11:29 am - 12:23 amDSM  Des Moines-ORD Chicago O'Hare Intl
12h 54m1 stop Denver Intl
$190Multiple Airlines
Thu, Sep 10 - Thu, Sep 17
Multiple Airlines Logo
5:55 am - 7:57 pmORD  Chicago O'Hare Intl-DSM Des Moines
14h 02m1 stop Philadelphia
Multiple Airlines Logo
1:58 pm - 7:29 amDSM  Des Moines-ORD Chicago O'Hare Intl
17h 31m1 stop Philadelphia
$201Multiple Airlines
Thu, Sep 3 - Sun, Sep 6
Southwest Logo
6:00 pm - 7:30 pmMDW  Chicago Midway-DSM Des Moines
1h 30mnonstop
Southwest Logo
5:40 am - 7:00 amDSM  Des Moines-MDW Chicago Midway
1h 20mnonstop
$206Southwest
Sat, Sep 5 - Mon, Sep 7
Southwest Logo
10:05 am - 11:25 amMDW  Chicago Midway-DSM Des Moines
1h 20mnonstop
Southwest Logo
5:40 am - 7:00 amDSM  Des Moines-MDW Chicago Midway
1h 20mnonstop
$206Southwest
Fri, Sep 11 - Mon, Sep 14
Southwest Logo
8:50 pm - 10:15 pmMDW  Chicago Midway-DSM Des Moines
1h 25mnonstop
Southwest Logo
3:50 pm - 5:10 pmDSM  Des Moines-MDW Chicago Midway
1h 20mnonstop
$206Southwest
Fri, Sep 11 - Mon, Sep 14
United Airlines Logo
11:00 am - 12:34 pmORD  Chicago O'Hare Intl-DSM Des Moines
1h 34mnonstop
United Airlines Logo
1:24 pm - 3:00 pmDSM  Des Moines-ORD Chicago O'Hare Intl
1h 36mnonstop
$215United Airlines
Tue, Sep 29 - Wed, Sep 30
United Airlines Logo
9:00 am - 10:30 amORD  Chicago O'Hare Intl-DSM Des Moines
1h 30mnonstop
United Airlines Logo
1:26 pm - 3:00 pmDSM  Des Moines-ORD Chicago O'Hare Intl
1h 34mnonstop
$215United Airlines
Thu, Sep 24 - Sat, Sep 26
American Airlines Logo
5:45 pm - 7:21 pmORD  Chicago O'Hare Intl-DSM Des Moines
1h 36mnonstop
American Airlines Logo
7:05 am - 9:00 amDSM  Des Moines-ORD Chicago O'Hare Intl
1h 55mnonstop
$215American Airlines
Mon, Sep 28 - Tue, Sep 29
American Airlines Logo
11:54 am - 1:28 pmORD  Chicago O'Hare Intl-DSM Des Moines
1h 34mnonstop
American Airlines Logo
1:58 pm - 3:42 pmDSM  Des Moines-ORD Chicago O'Hare Intl
1h 44mnonstop
$215American Airlines
Thu, Nov 12 - Sat, Nov 14

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American Airlines flights from Chicago to Des Moines

Our best American Airlines deals on Chicago to Des Moines flight tickets
American Airlines
Sep 3
ORD10:45 pmChicago O'Hare Intl
1h 35m
DSM12:20 amDes Moines
Sep 7
DSM7:49 pmDes Moines
1h 48m
ORD9:37 pmChicago O'Hare Intl
$216
American Airlines
Sep 26
ORD6:59 amChicago O'Hare Intl
1h 40m
DSM8:39 amDes Moines
Oct 3
DSM2:44 pmDes Moines
1h 46m
ORD4:30 pmChicago O'Hare Intl
$217
American Airlines
Sep 5
ORD11:54 amChicago O'Hare Intl
1h 31m
DSM1:25 pmDes Moines
Sep 6
DSM6:10 amDes Moines
1h 50m
ORD8:00 amChicago O'Hare Intl
$226

Frontier flights from Chicago to Des Moines

Our best Frontier deals on Chicago to Des Moines flight tickets
Frontier
Sep 9
ORD6:30 amChicago O'Hare Intl
28h 14m
1 stop
DSM10:44 amDes Moines
Sep 24
DSM11:29 amDes Moines
12h 54m
1 stop
ORD12:23 amChicago O'Hare Intl
$181
Frontier
Sep 10
ORD7:28 pmChicago O'Hare Intl
24h 05m
2 stops
DSM7:33 pmDes Moines
Sep 17
DSM11:29 amDes Moines
12h 54m
1 stop
ORD12:23 amChicago O'Hare Intl
$245
Frontier
Sep 11
ORD6:30 amChicago O'Hare Intl
13h 03m
1 stop
DSM7:33 pmDes Moines
Sep 14
DSM8:30 pmDes Moines
27h 53m
1 stop
ORD12:23 amChicago O'Hare Intl
$252

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 15, 2026.
Use the filters below to find and compare flights from Chicago to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoDes Moines

ORD Chicago O'Hare Intl - DSM Des Moines

ORDDSM

Chicago O'Hare Intl

Wed 9/9

6:30 am-10:44 am

1 stop28h 14m

Des Moines

Thu 9/24

11:29 am-12:23 am

1 stop12h 54m

$181

ChicagoDes Moines

ORD Chicago O'Hare Intl - DSM Des Moines

ORDDSM

Chicago O'Hare Intl

Thu 9/10

7:25 am-7:57 pm

1 stop12h 32m

Des Moines

Thu 9/17

11:29 am-12:23 am

1 stop12h 54m

$190

ChicagoDes Moines

ORD Chicago O'Hare Intl - DSM Des Moines

ORDDSM

Chicago O'Hare Intl

Thu 9/3

5:55 am-7:57 pm

1 stop14h 02m

Des Moines

Sun 9/6

1:58 pm-7:29 am

1 stop17h 31m

$201

ChicagoDes Moines

MDW Chicago Midway - DSM Des Moines

MDWDSM

Chicago Midway

Sat 9/5

6:00 pm-7:30 pm

Nonstop1h 30m

Des Moines

Mon 9/7

5:40 am-7:00 am

Nonstop1h 20m

$206
Quickest round-trip

ChicagoDes Moines

MDW Chicago Midway - DSM Des Moines

MDWDSM

Chicago Midway

Fri 9/11

10:05 am-11:25 am

Nonstop1h 20m

Des Moines

Mon 9/14

5:40 am-7:00 am

Nonstop1h 20m

$206

ChicagoDes Moines

MDW Chicago Midway - DSM Des Moines

MDWDSM

Chicago Midway

Fri 9/11

8:50 pm-10:15 pm

Nonstop1h 25m

Des Moines

Mon 9/14

3:50 pm-5:10 pm

Nonstop1h 20m

$206

ChicagoDes Moines

ORD Chicago O'Hare Intl - DSM Des Moines

ORDDSM

Chicago O'Hare Intl

Tue 9/29

11:00 am-12:34 pm

Nonstop1h 34m

Des Moines

Wed 9/30

1:24 pm-3:00 pm

Nonstop1h 36m

$215

ChicagoDes Moines

ORD Chicago O'Hare Intl - DSM Des Moines

ORDDSM

Chicago O'Hare Intl

Thu 9/24

9:00 am-10:30 am

Nonstop1h 30m

Des Moines

Sat 9/26

1:26 pm-3:00 pm

Nonstop1h 34m

$215

ChicagoDes Moines

ORD Chicago O'Hare Intl - DSM Des Moines

ORDDSM

Chicago O'Hare Intl

Mon 9/28

5:45 pm-7:21 pm

Nonstop1h 36m

Des Moines

Tue 9/29

7:05 am-9:00 am

Nonstop1h 55m

$215

ChicagoDes Moines

ORD Chicago O'Hare Intl - DSM Des Moines

ORDDSM

Chicago O'Hare Intl

Thu 11/12

11:54 am-1:28 pm

Nonstop1h 34m

Des Moines

Sat 11/14

1:58 pm-3:42 pm

Nonstop1h 44m

$215

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Chicago to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Chicago and Des Moines?

Prices are currently low for flights on this route.

Typical prices usually range from $372 to $627.
The lowest price recently found on this route was $181.

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in October, then September is your next best option. Flight prices from Chicago to Des Moines during September average around $273.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Chicago to Des Moines is on a Saturday. Travelers who choose to depart for Des Moines on a Saturday will often find tickets for as low as $279. Flights from Chicago to Des Moines on a Tuesday will generally be more expensive and average around $470. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is at noon. momondo users have found flights departing from Chicago to Des Moines at noon for as low as $224. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the afternoon because they tend to be around $461. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Chicago to Des Moines flight route?

Fly from Chicago Midway to Des Moines for the best Chicago - Des Moines flight prices

What cabin class options are available on Chicago to Des Moines flights?

There are 4 cabin classes available to choose from on Chicago to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago to Des Moines flights?

You could potentially save up to 14% on your flight if you consider stops on a Chicago to Des Moines flight.

How have Chicago to Des Moines flight prices changed over time?

As of August 2026, prices for Chicago to Des Moines flights are approximately 47% cheaper when compared to flights at the same time last year.

When to book flights from Chicago to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Des Moines (CHI to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Des Moines

Best Price Found

$135

Fastest flight time

1h 20m

Direct flights

Every day

Airports in Des Moines

1 airport
The best one-way flight to Des Moines from Chicago in the past 72 hours is $135. The best round-trip flight deal from Chicago to Des Moines found on momondo in the last 72 hours is $273.
The fastest flight from Chicago to Des Moines takes 1h 20m
Direct flights go from Chicago to Des Moines every day.
There is 1 airport in Des Moines. From Chicago there are direct flights to Des Moines (DSM).
Search flight deals

Frequently asked questions about flying from Chicago to Des Moines

  • How far is Chicago to Des Moines by plane?

    Chicago and Des Moines are 309.8 mi apart from one another. A reasonable flight in good conditions will take 1h 20m.

  • When did momondo last update prices for flights from Chicago to Des Moines Airport?

    Prices for flights from Chicago to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from Chicago to Des Moines Airport?

  • How old do you have to be to fly from Chicago to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Chicago to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Chicago to Des Moines?

  • What is the most popular airline from Chicago to Des Moines?

Best airlines flying from Chicago to Des Moines

Compare and see reviews for airlines that fly from Chicago to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $189Free CancellationRating
7.1
11,941 reviews
Search American Airlines flights
United AirlinesPriceFrom $189Free CancellationRating
7.4
10,111 reviews
Search United Airlines flights
SouthwestPriceFrom $209Free CancellationRating
8.0
4,219 reviews
Search Southwest flights

  • Southwest Flights From Chicago to Des Moines

    Southwest flies from Chicago to Des Moines around 6 times per week, with 4,219 momondo users rating the airline 8.0/10. The cheapest Southwest deal from Chicago to Des Moines in the last 72 hours was $209 (round-trip), much lower than the average airfare cost of $419 for Southwest flights on this route.

  • United Airlines Flights From Chicago to Des Moines

    Across 10,111 United Airlines reviews on momondo, the average score is 7.4/10. United Airlines flies from Chicago to Des Moines about 21 times each week, with ticket deals ranging from $189 to $423. Price data is based on momondo searches in the last 72 hours.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Urbandale
Newton
Osceola
Johnston
Boone
Oskaloosa
Norwalk
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Des Moines?

It is quick and easy to find Chicago to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Chicago to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Chicago on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Chicago to Des Moines?

momondo provides multiple filters to help you find the best flight to Des Moines from Chicago. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Chicago to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Des Moines trip

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