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Cheap flights from Charlotte to Des Moines from $100

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charlotte to Des Moines departing on 2/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Charlotte to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
9:22 pm - 10:51 pm
CLT
-
DSM
26h 29m
1 stop
Multiple Airlines Logo
10:23 am - 10:17 am
DSM
-
CLT
22h 54m
1 stop
$269Multiple Airlines
Wed, Apr 1 - Fri, May 1
Multiple Airlines Logo
1:24 pm - 1:46 pm
CLT
-
DSM
25h 22m
2 stops
Multiple Airlines Logo
10:23 am - 10:17 am
DSM
-
CLT
22h 54m
1 stop
$300Multiple Airlines
Wed, Apr 1 - Fri, May 1
Southwest Logo
7:35 am - 11:25 am
CLT
-
DSM
4h 50m
1 stop
Southwest Logo
3:15 pm - 8:55 pm
DSM
-
CLT
4h 40m
1 stop
$349Southwest
Tue, Apr 28 - Tue, May 12
American Airlines Logo
11:22 am - 12:52 pm
CLT
-
DSM
2h 30mnonstop
American Airlines Logo
1:38 pm - 5:02 pm
DSM
-
CLT
2h 24mnonstop
$351American Airlines
Tue, Apr 28 - Tue, May 12
Multiple Airlines Logo
6:43 pm - 6:32 pm
CLT
-
DSM
24h 49m
2 stops
Multiple Airlines Logo
3:32 pm - 8:26 am
DSM
-
CLT
15h 54m
1 stop
$353Multiple Airlines
Sat, Feb 14 - Sun, Feb 22
Southwest Logo
5:05 pm - 10:30 pm
CLT
-
DSM
6h 25m
1 stop
Southwest Logo
5:20 am - 4:30 pm
DSM
-
CLT
10h 10m
2 stops
$354Southwest
Mon, Feb 23 - Mon, Mar 2
Southwest Logo
12:55 pm - 10:30 pm
CLT
-
DSM
10h 35m
2 stops
Southwest Logo
5:20 am - 4:30 pm
DSM
-
CLT
10h 10m
2 stops
$359Southwest
Mon, Feb 23 - Mon, Mar 2
American Airlines Logo
7:41 pm - 9:15 pm
CLT
-
DSM
2h 34mnonstop
American Airlines Logo
5:54 am - 11:43 am
DSM
-
CLT
4h 49m
1 stop
$361American Airlines
Tue, Apr 28 - Tue, May 12
Delta Logo
5:30 am - 10:14 am
CLT
-
DSM
5h 44m
1 stop
Delta Logo
11:04 am - 7:21 pm
DSM
-
CLT
7h 17m
1 stop
$371Delta
Wed, Jul 8 - Sat, Jul 11
Southwest Logo
10:45 am - 7:15 pm
CLT
-
DSM
9h 30m
2 stops
Southwest Logo
6:10 am - 7:45 pm
DSM
-
CLT
12h 35m
2 stops
$379Southwest
Sat, Feb 28 - Sun, Mar 1

Southwest flights from Charlotte to Des Moines

Our best Southwest deals on Charlotte to Des Moines flight tickets
Southwest
Apr 28
CLT7:35 amCharlotte Douglas
4h 50m
1 stop
DSM11:25 amDes Moines
May 12
DSM3:15 pmDes Moines
4h 40m
1 stop
CLT8:55 pmCharlotte Douglas
$349
Southwest
Feb 23
CLT5:05 pmCharlotte Douglas
6h 25m
1 stop
DSM10:30 pmDes Moines
Mar 2
DSM5:20 amDes Moines
10h 10m
2 stops
CLT4:30 pmCharlotte Douglas
$354
Southwest
Feb 23
CLT12:55 pmCharlotte Douglas
10h 35m
2 stops
DSM10:30 pmDes Moines
Mar 2
DSM5:20 amDes Moines
10h 10m
2 stops
CLT4:30 pmCharlotte Douglas
$359

American Airlines flights from Charlotte to Des Moines

Our best American Airlines deals on Charlotte to Des Moines flight tickets
American Airlines
Apr 28
CLT11:22 amCharlotte Douglas
2h 30m
DSM12:52 pmDes Moines
May 12
DSM1:38 pmDes Moines
2h 24m
CLT5:02 pmCharlotte Douglas
$351
American Airlines
Apr 28
CLT7:41 pmCharlotte Douglas
2h 34m
DSM9:15 pmDes Moines
May 12
DSM5:54 amDes Moines
4h 49m
1 stop
CLT11:43 amCharlotte Douglas
$361
American Airlines
Feb 28
CLT11:40 amCharlotte Douglas
2h 37m
DSM1:17 pmDes Moines
Mar 1
DSM2:02 pmDes Moines
2h 23m
CLT5:25 pmCharlotte Douglas
$381

momondo Fare Finder

 
Customize your flight search to find flights from Charlotte to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from Charlotte to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 4/1

9:22 pm-10:51 pm

1 stop26h 29m

Des Moines

Fri 5/1

10:23 am-10:17 am

1 stop22h 54m

$269

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 4/1

1:24 pm-1:46 pm

2 stops25h 22m

Des Moines

Fri 5/1

10:23 am-10:17 am

1 stop22h 54m

$300

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Tue 4/28

7:35 am-11:25 am

1 stop4h 50m

Des Moines

Tue 5/12

3:15 pm-8:55 pm

1 stop4h 40m

$349

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Tue 4/28

11:22 am-12:52 pm

Nonstop2h 30m

Des Moines

Tue 5/12

1:38 pm-5:02 pm

Nonstop2h 24m

$351

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Sat 2/14

6:43 pm-6:32 pm

2 stops24h 49m

Des Moines

Sun 2/22

3:32 pm-8:26 am

1 stop15h 54m

$353

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Mon 2/23

5:05 pm-10:30 pm

1 stop6h 25m

Des Moines

Mon 3/2

5:20 am-4:30 pm

2 stops10h 10m

$354

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Mon 2/23

12:55 pm-10:30 pm

2 stops10h 35m

Des Moines

Mon 3/2

5:20 am-4:30 pm

2 stops10h 10m

$359

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Tue 4/28

7:41 pm-9:15 pm

Nonstop2h 34m

Des Moines

Tue 5/12

5:54 am-11:43 am

1 stop4h 49m

$361

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 7/8

5:30 am-10:14 am

1 stop5h 44m

Des Moines

Sat 7/11

11:04 am-7:21 pm

1 stop7h 17m

$371

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Sat 2/28

10:45 am-7:15 pm

2 stops9h 30m

Des Moines

Sun 3/1

6:10 am-7:45 pm

2 stops12h 35m

$379

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Charlotte to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in September, then March is your next best option. Flight prices from Charlotte to Des Moines during March average around $363.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Charlotte to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $406. Flights from Charlotte to Des Moines on a Saturday will generally be more expensive and average around $462. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from Charlotte to Des Moines in the afternoon for as low as $406. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the evening because they tend to be around $452. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Charlotte Douglas to Des Moines flight route?

Fly from Charlotte Douglas to Des Moines for the best Charlotte Douglas - Des Moines flight prices

How far in advance should I book a flight to Des Moines?

You are more likely to see cheaper flights to Des Moines from Charlotte when booking weeks ahead of your departure date. In general, you can expect to find flights to Des Moines for around $422 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Des Moines from Charlotte for as low as $254 on momondo.

What cabin class options are available on Charlotte Douglas to Des Moines flights?

There are 2 cabin classes available to choose from on Charlotte Douglas to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Charlotte to Des Moines flights?

You could potentially save up to 56% on your flight if you consider stops on a Charlotte to Des Moines flight.

How have Charlotte to Des Moines flight prices changed over time?

When to book flights from Charlotte to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Charlotte to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charlotte to Des Moines (CLT to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charlotte to Des Moines

Best Price Found

$376

Fastest flight time

2h 34m

Direct flights

Every day

Airports in Des Moines

1 airport
The best flight deal from Charlotte to Des Moines found on momondo in the last 72 hours is $376
The fastest flight from Charlotte to Des Moines takes 2h 34m
Direct flights go from Charlotte to Des Moines every day.
There is 1 airport in Des Moines. From Charlotte there are direct flights to Des Moines (DSM).
Search flight deals

  • How far is Charlotte Douglas to Des Moines by plane?

    Charlotte Douglas and Des Moines are 818.0 mi apart from one another. Flights usually cover this in 2h 34m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Charlotte Douglas Airport to Des Moines Airport?

    Prices for flights from Charlotte Douglas Airport to Des Moines Airport are updated daily.

  • How many operators does momondo search for flights from Charlotte Douglas Airport to Des Moines Airport?

  • How old do you have to be to fly from Charlotte Douglas Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charlotte Douglas Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Charlotte to Des Moines?

  • What is the most popular airline from Charlotte to Des Moines?

Best airlines flying from Charlotte to Des Moines

Compare and see reviews for airlines that fly from Charlotte to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $254Free CancellationRating
7.9
8,111 reviews
Search Delta flights
American AirlinesPriceFrom $257Free CancellationRating
7.2
11,189 reviews
Search American Airlines flights

  • American Airlines Flights From Charlotte to Des Moines

    American Airlines flight deals from Charlotte to Des Moines start from $257 round-trip. Over the 12 American Airlines flights for this route in a normal week, average airfare is usually $434 round-trip - but some users have found much cheaper deals with momondo.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Boone
Osceola
Norwalk
Oskaloosa
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Charlotte to Des Moines?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Des Moines from Charlotte.

Can I find flights from Charlotte to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Charlotte which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Charlotte to Des Moines?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Des Moines from Charlotte.

I’m not ready to book a flight from Charlotte to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Charlotte to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

An easier way to manage your Des Moines trip

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