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Cheap flights from Charlotte to Des Moines from $105

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Charlotte to Des Moines departing on 11/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Charlotte to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:45 am - 2:55 pmCLT-DSM
10h 10m1 stop
Multiple Airlines Logo
8:40 am - 10:08 pmDSM-CLT
12h 28m1 stop
$225Multiple Airlines
Find Deal
Fri, Nov 14 - Mon, Nov 17
Multiple Airlines Logo
5:45 am - 2:55 pmCLT-DSM
10h 10m1 stop
Multiple Airlines Logo
8:40 am - 10:08 pmDSM-CLT
12h 28m1 stop
$228Multiple Airlines
Find Deal
Fri, Nov 7 - Mon, Nov 10
Multiple Airlines Logo
5:45 am - 2:55 pmCLT-DSM
10h 10m1 stop
Multiple Airlines Logo
8:40 am - 11:08 pmDSM-CLT
13h 28m1 stop
$235Multiple Airlines
Find Deal
Fri, Nov 14 - Mon, Nov 17
Southwest Logo
6:25 pm - 11:35 pmCLT-DSM
6h 10m1 stop
Southwest Logo
6:15 am - 5:40 pmDSM-CLT
10h 25m1 stop
$358Southwest
Find Deal
Thu, Nov 6 - Tue, Nov 11
Southwest Logo
7:00 am - 7:55 pmCLT-DSM
13h 55m2 stops
Southwest Logo
6:15 am - 4:20 pmDSM-CLT
9h 05m2 stops
$363Southwest
Find Deal
Tue, Nov 4 - Wed, Nov 5
American Airlines Logo
2:40 pm - 4:21 pmCLT-DSM
2h 41mnonstop
American Airlines Logo
4:16 pm - 7:47 pmDSM-CLT
2h 31mnonstop
$373American Airlines
Find Deal
Wed, Nov 19 - Sat, Nov 22
American Airlines Logo
2:40 pm - 4:21 pmCLT-DSM
2h 41mnonstop
American Airlines Logo
8:51 am - 5:15 pmDSM-CLT
7h 24m1 stop
$383American Airlines
Find Deal
Wed, Nov 19 - Sat, Nov 22
Delta Logo
9:47 am - 1:32 pmCLT-DSM
4h 45m1 stop
Delta Logo
6:17 am - 11:59 amDSM-CLT
4h 42m1 stop
$393Delta
Find Deal
Tue, Nov 25 - Tue, Dec 2
United Airlines Logo
6:00 am - 12:14 pmCLT-DSM
7h 14m2 stops
United Airlines Logo
3:17 pm - 11:59 pmDSM-CLT
7h 42m2 stops
$403United Airlines
Find Deal
Tue, Nov 25 - Tue, Dec 2
Delta Logo
9:47 am - 1:32 pmCLT-DSM
4h 45m1 stop
Delta Logo
5:35 am - 10:55 amDSM-CLT
4h 20m1 stop
$417Delta
Find Deal
Thu, Nov 13 - Tue, Nov 18

Southwest flights from Charlotte to Des Moines

Our best Southwest deals on Charlotte to Des Moines flight tickets
Southwest
Nov 6
CLT6:25 pmCharlotte Douglas
6h 10m
1 stop
DSM11:35 pmDes Moines
Nov 11
DSM6:15 amDes Moines
10h 25m
1 stop
CLT5:40 pmCharlotte Douglas
$358
Find similar
Southwest
Nov 4
CLT7:00 amCharlotte Douglas
13h 55m
2 stops
DSM7:55 pmDes Moines
Nov 5
DSM6:15 amDes Moines
9h 05m
2 stops
CLT4:20 pmCharlotte Douglas
$363
Find similar
Southwest
Nov 4
CLT7:00 amCharlotte Douglas
13h 55m
2 stops
DSM7:55 pmDes Moines
Nov 5
DSM6:15 amDes Moines
10h 25m
1 stop
CLT5:40 pmCharlotte Douglas
$364
Find similar

American Airlines flights from Charlotte to Des Moines

Our best American Airlines deals on Charlotte to Des Moines flight tickets
American Airlines
Nov 19
CLT2:40 pmCharlotte Douglas
2h 41m
DSM4:21 pmDes Moines
Nov 22
DSM4:16 pmDes Moines
2h 31m
CLT7:47 pmCharlotte Douglas
$373
Find similar
American Airlines
Nov 19
CLT2:40 pmCharlotte Douglas
2h 41m
DSM4:21 pmDes Moines
Nov 22
DSM8:51 amDes Moines
7h 24m
1 stop
CLT5:15 pmCharlotte Douglas
$383
Find similar
American Airlines
Nov 27
CLT7:53 amCharlotte Douglas
5h 40m
1 stop
DSM12:33 pmDes Moines
Dec 2
DSM3:18 pmDes Moines
2h 19m
CLT6:37 pmCharlotte Douglas
$385
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Charlotte to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from Charlotte to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Fri 11/14

5:45 am-2:55 pm

1 stop10h 10m

Des Moines

Mon 11/17

8:40 am-10:08 pm

1 stop12h 28m

$225

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Fri 11/7

5:45 am-2:55 pm

1 stop10h 10m

Des Moines

Mon 11/10

8:40 am-10:08 pm

1 stop12h 28m

$228

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Fri 11/14

5:45 am-2:55 pm

1 stop10h 10m

Des Moines

Mon 11/17

8:40 am-11:08 pm

1 stop13h 28m

$235

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 11/6

6:25 pm-11:35 pm

1 stop6h 10m

Des Moines

Tue 11/11

6:15 am-5:40 pm

1 stop10h 25m

$358

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Tue 11/4

7:00 am-7:55 pm

2 stops13h 55m

Des Moines

Wed 11/5

6:15 am-4:20 pm

2 stops9h 05m

$363

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 11/19

2:40 pm-4:21 pm

Nonstop2h 41m

Des Moines

Sat 11/22

4:16 pm-7:47 pm

Nonstop2h 31m

$373

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 11/19

2:40 pm-4:21 pm

Nonstop2h 41m

Des Moines

Sat 11/22

8:51 am-5:15 pm

1 stop7h 24m

$383

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Tue 11/25

9:47 am-1:32 pm

1 stop4h 45m

Des Moines

Tue 12/2

6:17 am-11:59 am

1 stop4h 42m

$393

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Tue 11/25

6:00 am-12:14 pm

2 stops7h 14m

Des Moines

Tue 12/2

3:17 pm-11:59 pm

2 stops7h 42m

$403

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 11/13

9:47 am-1:32 pm

1 stop4h 45m

Des Moines

Tue 11/18

5:35 am-10:55 am

1 stop4h 20m

$417

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Charlotte to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in March, then September is your next best option. Flight prices from Charlotte to Des Moines during September average around $342.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Charlotte to Des Moines is on a Tuesday. Travelers who choose to depart for Des Moines on a Tuesday will often find tickets for as low as $397. Flights from Charlotte to Des Moines on a Monday will generally be more expensive and average around $505. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from Charlotte to Des Moines in the afternoon for as low as $406. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $445. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Charlotte Douglas to Des Moines flight route?

Fly from Charlotte Douglas to Des Moines for the best Charlotte Douglas - Des Moines flight prices

How far in advance should I book a flight to Des Moines?

You are more likely to see cheaper flights to Des Moines from Charlotte when booking weeks ahead of your departure date. In general, you can expect to find flights to Des Moines for around $421 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Des Moines from Charlotte for as low as $254 on momondo.

What cabin class options are available on Charlotte Douglas to Des Moines flights?

There is only 1 cabin class available to choose from on Charlotte Douglas to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Charlotte to Des Moines flights?

No. A direct flight is the cheapest option for a flight between Charlotte to Des Moines.

How have Charlotte to Des Moines flight prices changed over time?

As of October 2025, prices for Charlotte to Des Moines flights are approximately 119% more expensive when compared to flights at the same time last year.

When to book flights from Charlotte to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Charlotte to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Charlotte to Des Moines (CLT to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Charlotte to Des Moines

Best Price Found

$421

Fastest flight time

2h 28m

Direct flights

Every day

Airports in Des Moines

1 airport
The best flight deal from Charlotte to Des Moines found on momondo in the last 72 hours is $421
The fastest flight from Charlotte to Des Moines takes 2h 28m
Direct flights go from Charlotte to Des Moines every day.
There is 1 airport near Des Moines: Des Moines (DSM)
Search flight deals

  • How far is Charlotte Douglas to Des Moines by plane?

    Charlotte Douglas and Des Moines are 818.0 mi apart from one another. Flights usually cover this in 2h 32m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Charlotte Douglas Airport to Des Moines Airport?

    Prices for flights from Charlotte Douglas Airport to Des Moines Airport are updated daily.

  • How many operators does momondo search for flights from Charlotte Douglas Airport to Des Moines Airport?

  • How old do you have to be to fly from Charlotte Douglas Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Charlotte Douglas Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Charlotte to Des Moines?

  • What is the most popular airline from Charlotte to Des Moines?

Best airlines flying from Charlotte to Des Moines

Compare and see reviews for airlines that fly from Charlotte to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $232Free CancellationRating
7.9
7,975 reviews
Search Delta flights
American AirlinesPriceFrom $247Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights

  • American Airlines Flights From Charlotte to Des Moines

    American Airlines flight deals from Charlotte to Des Moines start from $247 round-trip. Over the 19 American Airlines flights for this route in a normal week, average airfare is usually $436 round-trip - but some users have found much cheaper deals with momondo.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Newton
Pella
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Charlotte to Des Moines?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Des Moines from Charlotte.

Can I find flights from Charlotte to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Charlotte which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Charlotte to Des Moines?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Des Moines from Charlotte.

I’m not ready to book a flight from Charlotte to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Charlotte to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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