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Cheap flights from Buffalo to St. Louis from $161

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to St. Louis departing on 12/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Buffalo to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
9:25 pm - 7:07 am
BUF
-
STL
10h 42m1 stop
Frontier Logo
4:51 pm - 10:49 am
STL
-
BUF
16h 58m1 stop
$295Frontier
vie., mar. 6 - dom., mar. 8
Frontier Logo
9:25 pm - 7:07 am
BUF
-
STL
10h 42m1 stop
Frontier Logo
7:42 am - 8:30 pm
STL
-
BUF
11h 48m1 stop
$297Frontier
vie., mar. 6 - dom., mar. 8
Frontier Logo
11:44 am - 11:19 pm
BUF
-
STL
12h 35m1 stop
Frontier Logo
4:51 pm - 12:05 pm
STL
-
BUF
18h 14m2 stops
$316Frontier
vie., mar. 6 - dom., mar. 8
United Airlines Logo
8:30 am - 12:29 pm
BUF
-
STL
4h 59m1 stop
United Airlines Logo
12:44 pm - 7:25 pm
STL
-
BUF
5h 41m1 stop
$335United Airlines
dom., ene. 18 - jue., ene. 22
United Airlines Logo
6:00 am - 2:30 pm
BUF
-
STL
9h 30m2 stops
United Airlines Logo
12:44 pm - 7:25 pm
STL
-
BUF
5h 41m1 stop
$340United Airlines
dom., ene. 18 - jue., ene. 22
United Airlines Logo
6:00 am - 2:30 pm
BUF
-
STL
9h 30m2 stops
United Airlines Logo
8:05 am - 7:25 pm
STL
-
BUF
10h 20m2 stops
$345United Airlines
dom., ene. 18 - jue., ene. 22
American Airlines Logo
5:24 pm - 9:52 pm
BUF
-
STL
5h 28m1 stop
American Airlines Logo
7:01 am - 3:23 pm
STL
-
BUF
7h 22m1 stop
$347American Airlines
dom., feb. 15 - jue., feb. 19
Southwest Logo
5:50 pm - 12:05 am
BUF
-
STL
7h 15m2 stops
Southwest Logo
8:25 am - 5:55 pm
STL
-
BUF
8h 30m2 stops
$397Southwest
vie., mar. 6 - dom., mar. 8
Southwest Logo
1:05 pm - 8:10 pm
BUF
-
STL
8h 05m1 stop
Southwest Logo
9:40 am - 9:35 pm
STL
-
BUF
10h 55m2 stops
$409Southwest
dom., feb. 15 - jue., feb. 19
United Airlines Logo
10:29 am - 4:27 pm
BUF
-
STL
6h 58m2 stops
United Airlines Logo
3:10 pm - 8:54 pm
STL
-
BUF
4h 44m1 stop
$413United Airlines
jue., dic. 25 - lun., dic. 29

Frontier flights from Buffalo to St. Louis

Our best Frontier deals on Buffalo to St. Louis flight tickets
Frontier
Mar 6
BUF9:25 pmBuffalo
10h 42m
1 stop
STL7:07 amLambert-St Louis
Mar 8
STL4:51 pmLambert-St Louis
16h 58m
1 stop
BUF10:49 amBuffalo
$295
Find similar
Frontier
Mar 6
BUF9:25 pmBuffalo
10h 42m
1 stop
STL7:07 amLambert-St Louis
Mar 8
STL7:42 amLambert-St Louis
11h 48m
1 stop
BUF8:30 pmBuffalo
$297
Find similar
Frontier
Mar 6
BUF11:44 amBuffalo
12h 35m
1 stop
STL11:19 pmLambert-St Louis
Mar 8
STL4:51 pmLambert-St Louis
18h 14m
2 stops
BUF12:05 pmBuffalo
$316
Find similar

Southwest flights from Buffalo to St. Louis

Our best Southwest deals on Buffalo to St. Louis flight tickets
Southwest
Mar 6
BUF5:50 pmBuffalo
7h 15m
2 stops
STL12:05 amLambert-St Louis
Mar 8
STL8:25 amLambert-St Louis
8h 30m
2 stops
BUF5:55 pmBuffalo
$397
Find similar
Southwest
Feb 15
BUF1:05 pmBuffalo
8h 05m
1 stop
STL8:10 pmLambert-St Louis
Feb 19
STL9:40 amLambert-St Louis
10h 55m
2 stops
BUF9:35 pmBuffalo
$409
Find similar
Southwest
Dec 20
BUF11:20 amBuffalo
8h 25m
2 stops
STL6:45 pmLambert-St Louis
Dec 30
STL4:50 pmLambert-St Louis
5h 45m
1 stop
BUF11:35 pmBuffalo
$517
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated diciembre 11, 2025.
Use the filters below to find and compare flights from Buffalo to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

vie. 3/6

9:25 pm-7:07 am

1 stop10h 42m

Lambert-St Louis

dom. 3/8

4:51 pm-10:49 am

1 stop16h 58m

$295

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

vie. 3/6

9:25 pm-7:07 am

1 stop10h 42m

Lambert-St Louis

dom. 3/8

7:42 am-8:30 pm

1 stop11h 48m

$297

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

vie. 3/6

11:44 am-11:19 pm

1 stop12h 35m

Lambert-St Louis

dom. 3/8

4:51 pm-12:05 pm

2 stops18h 14m

$316

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

dom. 1/18

8:30 am-12:29 pm

1 stop4h 59m

Lambert-St Louis

jue. 1/22

12:44 pm-7:25 pm

1 stop5h 41m

$335

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

dom. 1/18

6:00 am-2:30 pm

2 stops9h 30m

Lambert-St Louis

jue. 1/22

12:44 pm-7:25 pm

1 stop5h 41m

$340

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

dom. 1/18

6:00 am-2:30 pm

2 stops9h 30m

Lambert-St Louis

jue. 1/22

8:05 am-7:25 pm

2 stops10h 20m

$345

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

dom. 2/15

5:24 pm-9:52 pm

1 stop5h 28m

Lambert-St Louis

jue. 2/19

7:01 am-3:23 pm

1 stop7h 22m

$347

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

vie. 3/6

5:50 pm-12:05 am

2 stops7h 15m

Lambert-St Louis

dom. 3/8

8:25 am-5:55 pm

2 stops8h 30m

$397

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

dom. 2/15

1:05 pm-8:10 pm

1 stop8h 05m

Lambert-St Louis

jue. 2/19

9:40 am-9:35 pm

2 stops10h 55m

$409

BuffaloSt. Louis

BUF - STL

BUFSTL

Buffalo

jue. 12/25

10:29 am-4:27 pm

2 stops6h 58m

Lambert-St Louis

lun. 12/29

3:10 pm-8:54 pm

1 stop4h 44m

$413

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Buffalo to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, September is the cheapest month to fly from Buffalo to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $304. The month of July is another great option to travel to St. Louis, with average flight prices from Buffalo averaging around $312.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $326. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $486. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Buffalo at noon is the least expensive time of day to depart. momondo users have found prices as low as $328 when looking at flights departing at noon. In the evening is when there is more demand to fly to St. Louis, so prices are often more expensive at around $416 per ticket.

How have Buffalo to St. Louis flight prices changed over time?

As of December 2025, prices for Buffalo to St. Louis flights are approximately 55% cheaper when compared to flights at the same time last year.

When to book flights from Buffalo to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to St. Louis (BUF to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to St. Louis

Fastest flight time

4h 10m

Direct flights

None
The fastest flight from Buffalo to St. Louis takes 4h 10m
There are no direct flights from Buffalo to St. Louis. There are no popular flight routes from Buffalo to St. Louis.
Search flight deals

  • How far is Buffalo to Lambert-St Louis by plane?

    A flight from Buffalo to Lambert-St Louis will travel around 660.3 mi. Flights usually cover this in 4h 10m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Buffalo Airport to Lambert-St Louis Airport?

    Prices for flights from Buffalo Airport to Lambert-St Louis Airport were last updated today.

  • How many operators does momondo search for flights from Buffalo Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Buffalo Airport to Lambert-St Louis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Buffalo to St. Louis?

Best airlines flying from Buffalo to St. Louis

Compare and see reviews for airlines that fly from Buffalo to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $164Free CancellationRating
7.9
8,008 reviews
Search Delta flights
American AirlinesPriceFrom $243Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights
United AirlinesPriceFrom $296Free CancellationRating
7.4
9,095 reviews
Search United Airlines flights
SouthwestPriceFrom $338Free CancellationRating
7.9
4,253 reviews
Search Southwest flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
Fenton
Wentzville
St. Peters
Collinsville
Alton
Farmington
Festus
Clayton
Glencoe
Edwardsville
Eureka
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to St. Louis?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Buffalo to St. Louis. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Buffalo to St. Louis with flexible booking policies on momondo?

All flight searches from Buffalo to St. Louis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Buffalo to St. Louis?

Once all potential Buffalo to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Buffalo to St. Louis right now. Can momondo alert me if prices change?

If you are simply researching potential flights to St. Louis, momondo offers a useful price alert feature which will track prices for flights to St. Louis from Buffalo and alert you when they change.

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