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Cheap flights from Buffalo to South America from $127

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to South America departing on 2/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Buffalo to South America

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:41 pm - 2:06 pm
BUF
-
MDE
18h 25m
2 stops
American Airlines Logo
3:10 pm - 12:51 pm
MDE
-
BUF
21h 41m
2 stops
$265American Airlines
Mon, Feb 23 - Mon, Mar 2
JetBlue Logo
6:00 am - 2:40 pm
BUF
-
CTG
8h 40m
1 stop
JetBlue Logo
2:35 pm - 11:36 pm
CTG
-
BUF
9h 01m
1 stop
$299JetBlue
Sun, Feb 22 - Wed, Mar 4
United Airlines Logo
7:21 pm - 10:05 pm
BUF
-
MDE
26h 44m
2 stops
United Airlines Logo
10:45 am - 8:51 pm
MDE
-
BUF
34h 06m
2 stops
$324United Airlines
Fri, Feb 20 - Wed, Feb 25
United Airlines Logo
7:00 am - 10:05 pm
BUF
-
MDE
39h 05m
2 stops
United Airlines Logo
10:45 am - 8:51 pm
MDE
-
BUF
34h 06m
2 stops
$330United Airlines
Thu, Feb 26 - Mon, Mar 2
Multiple Airlines Logo
1:39 pm - 2:15 pm
BUF
-
MDE
24h 36m
2 stops
Multiple Airlines Logo
1:52 pm - 10:49 am
MDE
-
BUF
19h 57m
1 stop
$363Multiple Airlines
Mon, Feb 9 - Sat, Mar 28
Delta Logo
6:00 am - 1:15 pm
BUF
-
CTG
8h 15m
1 stop
Delta Logo
2:30 pm - 11:46 pm
CTG
-
BUF
8h 16m
1 stop
$379Delta
Tue, Mar 10 - Thu, Mar 26
Multiple Airlines Logo
6:00 am - 2:40 pm
BUF
-
CTG
8h 40m
1 stop
Multiple Airlines Logo
3:32 pm - 2:56 pm
CTG
-
BUF
23h 24m
2 stops
$400Multiple Airlines
Sun, Feb 22 - Wed, Mar 4
LATAM Airlines Logo
12:07 pm - 7:30 pm
BUF
-
BOG
8h 23m
1 stop
LATAM Airlines Logo
9:00 am - 11:46 pm
BOG
-
BUF
13h 46m
1 stop
$517LATAM Airlines
Thu, Mar 12 - Thu, Mar 19
Delta Logo
4:47 pm - 8:35 pm
BUF
-
UIO
28h 48m
1 stop
Delta Logo
11:45 pm - 11:01 am
UIO
-
BUF
10h 16m
1 stop
$632Delta
Mon, Mar 16 - Tue, Mar 24
LATAM Airlines Logo
12:06 pm - 4:43 am
BUF
-
UIO
17h 37m
2 stops
LATAM Airlines Logo
7:06 am - 11:02 am
UIO
-
BUF
26h 56m
2 stops
$643LATAM Airlines
Tue, May 5 - Wed, May 6

LATAM Airlines flights from Buffalo to South America

Our best LATAM Airlines deals on Buffalo to South America flight tickets
LATAM Airlines
Mar 10
BUF6:00 amBuffalo
8h 15m
1 stop
CTG1:15 pmCartagena Rafael Nunez
Mar 26
CTG2:30 pmCartagena Rafael Nunez
19h 27m
2 stops
BUF10:57 amBuffalo
$454
LATAM Airlines
Feb 6
BUF6:00 amBuffalo
25h 15m
2 stops
MDE7:15 amMedellín Jose Maria Cordova Intl
Feb 17
MDE6:30 amMedellín Jose Maria Cordova Intl
28h 30m
2 stops
BUF11:00 amBuffalo
$458
LATAM Airlines
Jan 31
BUF6:00 amBuffalo
8h 17m
1 stop
CTG2:17 pmCartagena Rafael Nunez
Feb 4
CTG3:32 pmCartagena Rafael Nunez
7h 56m
1 stop
BUF11:28 pmBuffalo
$459

Delta flights from Buffalo to South America

Our best Delta deals on Buffalo to South America flight tickets
Delta
Mar 10
BUF6:00 amBuffalo
8h 15m
1 stop
CTG1:15 pmCartagena Rafael Nunez
Mar 26
CTG2:30 pmCartagena Rafael Nunez
8h 16m
1 stop
BUF11:46 pmBuffalo
$379
Delta
Mar 18
BUF6:00 amBuffalo
15h 01m
2 stops
CTG8:01 pmCartagena Rafael Nunez
Mar 31
CTG2:30 pmCartagena Rafael Nunez
8h 16m
1 stop
BUF11:46 pmBuffalo
$502
Delta
Feb 21
BUF6:00 amBuffalo
8h 17m
1 stop
CTG2:17 pmCartagena Rafael Nunez
Feb 24
CTG3:32 pmCartagena Rafael Nunez
7h 54m
1 stop
BUF11:26 pmBuffalo
$508

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from Buffalo to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloMedellín

BUF - MDE

BUFMDE

Buffalo

Mon 2/23

7:41 pm-2:06 pm

2 stops18h 25m

Medellín Jose Maria Cordova Intl

Mon 3/2

3:10 pm-12:51 pm

2 stops21h 41m

$265

BuffaloCartagena

BUF - CTG

BUFCTG

Buffalo

Sun 2/22

6:00 am-2:40 pm

1 stop8h 40m

Cartagena Rafael Nunez

Wed 3/4

2:35 pm-11:36 pm

1 stop9h 01m

$299

BuffaloMedellín

BUF - MDE

BUFMDE

Buffalo

Fri 2/20

7:21 pm-10:05 pm

2 stops26h 44m

Medellín Jose Maria Cordova Intl

Wed 2/25

10:45 am-8:51 pm

2 stops34h 06m

$324

BuffaloMedellín

BUF - MDE

BUFMDE

Buffalo

Thu 2/26

7:00 am-10:05 pm

2 stops39h 05m

Medellín Jose Maria Cordova Intl

Mon 3/2

10:45 am-8:51 pm

2 stops34h 06m

$330

BuffaloMedellín

BUF - MDE

BUFMDE

Buffalo

Mon 2/9

1:39 pm-2:15 pm

2 stops24h 36m

Medellín Jose Maria Cordova Intl

Sat 3/28

1:52 pm-10:49 am

1 stop19h 57m

$363

BuffaloCartagena

BUF - CTG

BUFCTG

Buffalo

Tue 3/10

6:00 am-1:15 pm

1 stop8h 15m

Cartagena Rafael Nunez

Thu 3/26

2:30 pm-11:46 pm

1 stop8h 16m

$379

BuffaloCartagena

BUF - CTG

BUFCTG

Buffalo

Sun 2/22

6:00 am-2:40 pm

1 stop8h 40m

Cartagena Rafael Nunez

Wed 3/4

3:32 pm-2:56 pm

2 stops23h 24m

$400

BuffaloBogotá

BUF - BOG

BUFBOG

Buffalo

Thu 3/12

12:07 pm-7:30 pm

1 stop8h 23m

Bogotá El Dorado

Thu 3/19

9:00 am-11:46 pm

1 stop13h 46m

$517

BuffaloQuito

BUF - UIO

BUFUIO

Buffalo

Mon 3/16

4:47 pm-8:35 pm

1 stop28h 48m

Quito Mariscal Sucr

Tue 3/24

11:45 pm-11:01 am

1 stop10h 16m

$632

BuffaloQuito

BUF - UIO

BUFUIO

Buffalo

Tue 5/5

12:06 pm-4:43 am

2 stops17h 37m

Quito Mariscal Sucr

Wed 5/6

7:06 am-11:02 am

2 stops26h 56m

$643

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Buffalo to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Buffalo to South America flights?

You could potentially save up to 21% on your flight if you consider stops on a Buffalo to South America flight.

Cheap Buffalo to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to South America

Fastest flight time

7h 35m

Direct flights

None
The fastest flight from Buffalo to South America takes 7h 35m
There are no direct flights from Buffalo to South America. There are no popular flight routes from Buffalo to South America.
Search flight deals

  • When did momondo last update prices for flights from Buffalo Airport to South America?

    Prices for flights from Buffalo Airport to South America refresh daily.

  • How many operators does momondo search for flights from Buffalo Airport to South America?

  • How old do you have to be to fly from Buffalo Airport to South America?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Buffalo Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Buffalo to South America

Compare and see reviews for airlines that fly from Buffalo to South America with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $320Free CancellationRating
7.9
8,111 reviews
Search Delta flights
LATAM AirlinesPriceFrom $494Free CancellationRating
7.5
1,912 reviews
Search LATAM Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to South America?

Finding the right flight to South America from Buffalo is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South America quick and easy, saving you time and money.

Can I find flights from Buffalo to South America with flexible booking policies on momondo?

Flights from Buffalo to South America with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Buffalo to South America?

momondo provides multiple filters to help you find the best flight to South America from Buffalo. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Buffalo to South America right now. Can momondo alert me if prices change?

Price alerts on flights to South America from Buffalo are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo
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Flights to Bogotáfrom $162
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Flights to Medellínfrom $168
Flights to Santiagofrom $357
Flights to Cartagenafrom $139
Flights to Quitofrom $278
Flights to Cuscofrom $457
Flights to Guayaquilfrom $54
Flights to Califrom $203