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Cheap flights from Buffalo to South America from $152

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to South America departing on 1/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Buffalo to South America

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
6:00 am - 2:50 pm
BUF
-
CTG
8h 50m1 stop
JetBlue Logo
2:20 pm - 11:47 pm
CTG
-
BUF
9h 27m1 stop
$282JetBlue
Sun, Jan 25 - Thu, Jan 29
American Airlines Logo
4:25 pm - 2:06 pm
BUF
-
MDE
21h 41m2 stops
American Airlines Logo
3:10 pm - 10:44 am
MDE
-
BUF
19h 34m2 stops
$298American Airlines
Fri, Feb 20 - Wed, Feb 25
United Airlines Logo
6:07 am - 10:05 pm
BUF
-
MDE
15h 58m2 stops
United Airlines Logo
9:45 am - 8:51 pm
MDE
-
BUF
34h 06m2 stops
$320United Airlines
Sun, Mar 1 - Thu, Mar 12
United Airlines Logo
6:07 am - 10:05 pm
BUF
-
MDE
15h 58m2 stops
United Airlines Logo
9:45 am - 8:51 pm
MDE
-
BUF
34h 06m2 stops
$364United Airlines
Mon, Mar 2 - Thu, Mar 12
LATAM Airlines Logo
6:00 am - 2:17 pm
BUF
-
CTG
8h 17m1 stop
LATAM Airlines Logo
3:32 pm - 11:28 pm
CTG
-
BUF
7h 56m1 stop
$382LATAM Airlines
Fri, Jan 23 - Wed, Jan 28
Delta Logo
3:43 pm - 2:17 pm
BUF
-
CTG
22h 34m2 stops
Delta Logo
3:32 pm - 9:53 am
CTG
-
BUF
18h 21m2 stops
$387Delta
Sat, Jan 17 - Wed, Jan 21
Delta Logo
2:10 pm - 2:17 pm
BUF
-
CTG
24h 07m1 stop
Delta Logo
3:32 pm - 11:28 pm
CTG
-
BUF
7h 56m1 stop
$390Delta
Sat, Jan 17 - Wed, Jan 21
Multiple Airlines Logo
9:57 am - 1:55 pm
BUF
-
MDE
27h 58m1 stop
Multiple Airlines Logo
2:50 pm - 5:11 pm
MDE
-
BUF
26h 21m1 stop
$407Multiple Airlines
Mon, Feb 23 - Mon, Mar 2
LATAM Airlines Logo
3:38 pm - 2:17 pm
BUF
-
CTG
22h 39m2 stops
LATAM Airlines Logo
3:32 pm - 2:58 pm
CTG
-
BUF
23h 26m2 stops
$412LATAM Airlines
Sun, Jan 25 - Thu, Jan 29
Multiple Airlines Logo
6:00 am - 2:17 pm
BUF
-
CTG
8h 17m1 stop
Multiple Airlines Logo
2:21 pm - 7:04 pm
CTG
-
BUF
28h 43m2 stops
$428Multiple Airlines
Fri, Jan 23 - Wed, Jan 28

Delta flights from Buffalo to South America

Our best Delta deals on Buffalo to South America flight tickets
Delta
Jan 17
BUF3:43 pmBuffalo
22h 34m
2 stops
CTG2:17 pmCartagena Rafael Nunez
Jan 21
CTG3:32 pmCartagena Rafael Nunez
18h 21m
2 stops
BUF9:53 amBuffalo
$387
Find similar
Delta
Jan 17
BUF2:10 pmBuffalo
24h 07m
1 stop
CTG2:17 pmCartagena Rafael Nunez
Jan 21
CTG3:32 pmCartagena Rafael Nunez
7h 56m
1 stop
BUF11:28 pmBuffalo
$390
Find similar
Delta
May 4
BUF6:00 amBuffalo
14h 25m
1 stop
BOG7:25 pmBogotá El Dorado
May 11
BOG2:55 pmBogotá El Dorado
21h 51m
2 stops
BUF1:46 pmBuffalo
$468
Find similar

United Airlines flights from Buffalo to South America

Our best United Airlines deals on Buffalo to South America flight tickets
United Airlines
Mar 1
BUF6:07 amBuffalo
15h 58m
2 stops
MDE10:05 pmMedellín Jose Maria Cordova Intl
Mar 12
MDE9:45 amMedellín Jose Maria Cordova Intl
34h 06m
2 stops
BUF8:51 pmBuffalo
$320
Find similar
United Airlines
Mar 2
BUF6:07 amBuffalo
15h 58m
2 stops
MDE10:05 pmMedellín Jose Maria Cordova Intl
Mar 12
MDE9:45 amMedellín Jose Maria Cordova Intl
34h 06m
2 stops
BUF8:51 pmBuffalo
$364
Find similar
United Airlines
Mar 5
BUF7:30 pmBuffalo
26h 35m
2 stops
MDE10:05 pmMedellín Jose Maria Cordova Intl
Mar 12
MDE9:45 amMedellín Jose Maria Cordova Intl
34h 06m
2 stops
BUF8:51 pmBuffalo
$372
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 6, 2025.
Use the filters below to find and compare flights from Buffalo to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloCartagena

BUF - CTG

BUFCTG

Buffalo

Sun 1/25

6:00 am-2:50 pm

1 stop8h 50m

Cartagena Rafael Nunez

Thu 1/29

2:20 pm-11:47 pm

1 stop9h 27m

$282

BuffaloMedellín

BUF - MDE

BUFMDE

Buffalo

Fri 2/20

4:25 pm-2:06 pm

2 stops21h 41m

Medellín Jose Maria Cordova Intl

Wed 2/25

3:10 pm-10:44 am

2 stops19h 34m

$298

BuffaloMedellín

BUF - MDE

BUFMDE

Buffalo

Sun 3/1

6:07 am-10:05 pm

2 stops15h 58m

Medellín Jose Maria Cordova Intl

Thu 3/12

9:45 am-8:51 pm

2 stops34h 06m

$320

BuffaloMedellín

BUF - MDE

BUFMDE

Buffalo

Mon 3/2

6:07 am-10:05 pm

2 stops15h 58m

Medellín Jose Maria Cordova Intl

Thu 3/12

9:45 am-8:51 pm

2 stops34h 06m

$364

BuffaloCartagena

BUF - CTG

BUFCTG

Buffalo

Fri 1/23

6:00 am-2:17 pm

1 stop8h 17m

Cartagena Rafael Nunez

Wed 1/28

3:32 pm-11:28 pm

1 stop7h 56m

$382

BuffaloCartagena

BUF - CTG

BUFCTG

Buffalo

Sat 1/17

3:43 pm-2:17 pm

2 stops22h 34m

Cartagena Rafael Nunez

Wed 1/21

3:32 pm-9:53 am

2 stops18h 21m

$387

BuffaloCartagena

BUF - CTG

BUFCTG

Buffalo

Sat 1/17

2:10 pm-2:17 pm

1 stop24h 07m

Cartagena Rafael Nunez

Wed 1/21

3:32 pm-11:28 pm

1 stop7h 56m

$390

BuffaloMedellín

BUF - MDE

BUFMDE

Buffalo

Mon 2/23

9:57 am-1:55 pm

1 stop27h 58m

Medellín Jose Maria Cordova Intl

Mon 3/2

2:50 pm-5:11 pm

1 stop26h 21m

$407

BuffaloCartagena

BUF - CTG

BUFCTG

Buffalo

Sun 1/25

3:38 pm-2:17 pm

2 stops22h 39m

Cartagena Rafael Nunez

Thu 1/29

3:32 pm-2:58 pm

2 stops23h 26m

$412

BuffaloCartagena

BUF - CTG

BUFCTG

Buffalo

Fri 1/23

6:00 am-2:17 pm

1 stop8h 17m

Cartagena Rafael Nunez

Wed 1/28

2:21 pm-7:04 pm

2 stops28h 43m

$428

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Buffalo to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Buffalo to South America is on a Tuesday when prices can be found for as low as $441. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Buffalo to South America for around $1,649.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest Buffalo to South America flights are usually those with departure times in the afternoon. Our users have found flights to South America in the afternoon for as low as $631. If you have a flexible travel schedule, then try to avoid flying in the morning when prices are $661 on average. Flights to South America from Buffalo in the morning are generally more expensive because this time of day is more convenient for travelers’ schedules.

Can stopping save me money on Buffalo to South America flights?

You could potentially save up to 12% on your flight if you consider stops on a Buffalo to South America flight.

Cheap Buffalo to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to South America

Fastest flight time

8h 40m

Direct flights

None
The fastest flight from Buffalo to South America takes 8h 40m
There are no direct flights from Buffalo to South America. There are no popular flight routes from Buffalo to South America.
Search flight deals

  • When did momondo last update prices for flights from Buffalo Airport to South America?

    Prices for flights from Buffalo Airport to South America refresh daily.

  • How many operators does momondo search for flights from Buffalo Airport to South America?

  • How old do you have to be to fly from Buffalo Airport to South America?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Buffalo Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Buffalo to South America

Compare and see reviews for airlines that fly from Buffalo to South America with momondo
Airline
Rating
Free Cancellation
Price
LATAM AirlinesPriceFrom $398Free CancellationRating
7.5
1,889 reviews
Search LATAM Airlines flights
DeltaPriceFrom $467Free CancellationRating
7.9
8,010 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to South America?

Finding the right flight to South America from Buffalo is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South America quick and easy, saving you time and money.

Can I find flights from Buffalo to South America with flexible booking policies on momondo?

Flights from Buffalo to South America with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Buffalo to South America?

momondo provides multiple filters to help you find the best flight to South America from Buffalo. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Buffalo to South America right now. Can momondo alert me if prices change?

Price alerts on flights to South America from Buffalo are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
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Find better results for your trip to South America

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Popular flights according to clicks in the last 7 days on momondo
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