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Cheap flights from Buffalo to Knoxville from $209

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Knoxville departing on 6/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Buffalo to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:17 pm - 6:26 pm
BUF
-
TYS
23h 09m
1 stop
Multiple Airlines Logo
6:24 pm - 12:05 pm
TYS
-
BUF
41h 41m
2 stops
$277Multiple Airlines
Tue, Mar 3 - Tue, Mar 10
Multiple Airlines Logo
8:59 pm - 10:24 pm
BUF
-
TYS
25h 25m
1 stop
Multiple Airlines Logo
12:45 pm - 12:13 pm
TYS
-
BUF
23h 28m
2 stops
$280Multiple Airlines
Sun, Apr 12 - Mon, Apr 20
Multiple Airlines Logo
8:59 pm - 10:24 pm
BUF
-
TYS
25h 25m
1 stop
Multiple Airlines Logo
1:15 pm - 7:13 pm
TYS
-
BUF
5h 58m
1 stop
$285Multiple Airlines
Sun, Apr 12 - Mon, Apr 20
Delta Logo
6:15 am - 12:11 pm
BUF
-
TYS
5h 56m
1 stop
Delta Logo
11:18 am - 5:09 pm
TYS
-
BUF
5h 51m
1 stop
$307Delta
Tue, Mar 3 - Tue, Mar 10
American Airlines Logo
7:51 pm - 11:50 pm
BUF
-
TYS
3h 59m
1 stop
American Airlines Logo
7:02 am - 12:51 pm
TYS
-
BUF
5h 49m
1 stop
$308American Airlines
Sat, Mar 28 - Wed, Apr 1
United Airlines Logo
6:07 am - 1:15 pm
BUF
-
TYS
7h 08m
2 stops
United Airlines Logo
9:40 am - 2:14 pm
TYS
-
BUF
4h 34m
1 stop
$312United Airlines
Tue, Mar 3 - Tue, Mar 10
American Airlines Logo
7:02 pm - 11:50 pm
BUF
-
TYS
4h 48m
1 stop
American Airlines Logo
5:00 am - 12:14 pm
TYS
-
BUF
7h 14m
2 stops
$313American Airlines
Sat, Mar 28 - Wed, Apr 1
United Airlines Logo
6:07 am - 1:15 pm
BUF
-
TYS
7h 08m
2 stops
United Airlines Logo
1:53 pm - 11:42 pm
TYS
-
BUF
9h 49m
2 stops
$317United Airlines
Tue, Mar 3 - Tue, Mar 10
American Airlines Logo
11:31 am - 4:40 pm
BUF
-
TYS
5h 09m
1 stop
American Airlines Logo
7:50 am - 2:21 pm
TYS
-
BUF
6h 31m
1 stop
$318American Airlines
Fri, Apr 17 - Mon, Apr 20
Multiple Airlines Logo
11:25 am - 9:14 pm
BUF
-
TYS
9h 49m
1 stop
Multiple Airlines Logo
5:10 pm - 8:47 am
TYS
-
BUF
15h 37m
1 stop
$320Multiple Airlines
Thu, May 7 - Thu, May 14

Southwest flights from Buffalo to Knoxville

Our best Southwest deals on Buffalo to Knoxville flight tickets
Southwest
May 7
BUF5:20 pmBuffalo
3h 55m
1 stop
TYS9:15 pmKnoxville McGhee Tyson
May 27
TYS12:50 pmKnoxville McGhee Tyson
9h 25m
2 stops
BUF10:15 pmBuffalo
$342
Southwest
May 7
BUF9:25 amBuffalo
8h 45m
2 stops
TYS6:10 pmKnoxville McGhee Tyson
May 27
TYS7:05 amKnoxville McGhee Tyson
7h 30m
2 stops
BUF2:35 pmBuffalo
$347
Southwest
Apr 17
BUF11:25 amBuffalo
8h 55m
2 stops
TYS8:20 pmKnoxville McGhee Tyson
Apr 20
TYS12:15 pmKnoxville McGhee Tyson
11h 00m
1 stop
BUF11:15 pmBuffalo
$348

American Airlines flights from Buffalo to Knoxville

Our best American Airlines deals on Buffalo to Knoxville flight tickets
American Airlines
Mar 28
BUF7:51 pmBuffalo
3h 59m
1 stop
TYS11:50 pmKnoxville McGhee Tyson
Apr 1
TYS7:02 amKnoxville McGhee Tyson
5h 49m
1 stop
BUF12:51 pmBuffalo
$308
American Airlines
Mar 28
BUF7:02 pmBuffalo
4h 48m
1 stop
TYS11:50 pmKnoxville McGhee Tyson
Apr 1
TYS5:00 amKnoxville McGhee Tyson
7h 14m
2 stops
BUF12:14 pmBuffalo
$313
American Airlines
Apr 17
BUF11:31 amBuffalo
5h 09m
1 stop
TYS4:40 pmKnoxville McGhee Tyson
Apr 20
TYS7:50 amKnoxville McGhee Tyson
6h 31m
1 stop
BUF2:21 pmBuffalo
$318

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Tue 3/3

7:17 pm-6:26 pm

1 stop23h 09m

Knoxville McGhee Tyson

Tue 3/10

6:24 pm-12:05 pm

2 stops41h 41m

$277

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sun 4/12

8:59 pm-10:24 pm

1 stop25h 25m

Knoxville McGhee Tyson

Mon 4/20

12:45 pm-12:13 pm

2 stops23h 28m

$280

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sun 4/12

8:59 pm-10:24 pm

1 stop25h 25m

Knoxville McGhee Tyson

Mon 4/20

1:15 pm-7:13 pm

1 stop5h 58m

$285

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Tue 3/3

6:15 am-12:11 pm

1 stop5h 56m

Knoxville McGhee Tyson

Tue 3/10

11:18 am-5:09 pm

1 stop5h 51m

$307

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sat 3/28

7:51 pm-11:50 pm

1 stop3h 59m

Knoxville McGhee Tyson

Wed 4/1

7:02 am-12:51 pm

1 stop5h 49m

$308

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Tue 3/3

6:07 am-1:15 pm

2 stops7h 08m

Knoxville McGhee Tyson

Tue 3/10

9:40 am-2:14 pm

1 stop4h 34m

$312

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sat 3/28

7:02 pm-11:50 pm

1 stop4h 48m

Knoxville McGhee Tyson

Wed 4/1

5:00 am-12:14 pm

2 stops7h 14m

$313

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Tue 3/3

6:07 am-1:15 pm

2 stops7h 08m

Knoxville McGhee Tyson

Tue 3/10

1:53 pm-11:42 pm

2 stops9h 49m

$317

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Fri 4/17

11:31 am-4:40 pm

1 stop5h 09m

Knoxville McGhee Tyson

Mon 4/20

7:50 am-2:21 pm

1 stop6h 31m

$318

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 5/7

11:25 am-9:14 pm

1 stop9h 49m

Knoxville McGhee Tyson

Thu 5/14

5:10 pm-8:47 am

1 stop15h 37m

$320

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Buffalo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of March is, on average, the cheapest month to fly to Knoxville from Buffalo, with most prices found around $253. If you aren’t able to travel during the month of March, then book flights to Knoxville from Buffalo during May instead. Flights to Knoxville in May, while not as cheap as those in March, still average around $303.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Buffalo when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $373 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Buffalo for as low as $293 on momondo.

When to book flights from Buffalo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Knoxville (BUF to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Knoxville

Fastest flight time

3h 44m

Direct flights

None
The fastest flight from Buffalo to Knoxville takes 3h 44m
There are no direct flights from Buffalo to Knoxville. There are no popular flight routes from Buffalo to Knoxville.
Search flight deals

  • How far is Buffalo to Knoxville McGhee Tyson by plane?

    The distance between Buffalo and Knoxville McGhee Tyson is about 548.4 mi. By plane, this route typically takes 3h 44m.

  • When did momondo last update prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Buffalo Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Buffalo to Knoxville?

Best airlines flying from Buffalo to Knoxville

Compare and see reviews for airlines that fly from Buffalo to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $224Free CancellationRating
7.4
9,236 reviews
Search United Airlines flights
DeltaPriceFrom $232Free CancellationRating
7.9
8,138 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,217 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Buffalo to Knoxville for you.

Can I find flights from Buffalo to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Buffalo to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Buffalo to Knoxville?

momondo helps you find the best flight between Buffalo and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Buffalo to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Buffalo to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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