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Cheap flights from Buffalo to Knoxville from $110

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Knoxville departing on 7/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Buffalo to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:57 pm - 7:05 pm
BUF
-
TYS
22h 08m
1 stop
Multiple Airlines Logo
2:49 pm - 10:40 am
TYS
-
BUF
19h 51m
2 stops
$234Multiple Airlines
Sun, Aug 23 - Mon, Aug 31
Multiple Airlines Logo
9:02 pm - 9:13 pm
BUF
-
TYS
24h 11m
1 stop
Multiple Airlines Logo
10:03 pm - 10:55 am
TYS
-
BUF
12h 52m
2 stops
$235Multiple Airlines
Thu, Jun 25 - Mon, Jun 29
Multiple Airlines Logo
9:02 pm - 9:13 pm
BUF
-
TYS
24h 11m
1 stop
Multiple Airlines Logo
10:03 pm - 7:12 pm
TYS
-
BUF
21h 09m
1 stop
$255Multiple Airlines
Thu, Jun 25 - Mon, Jun 29
Multiple Airlines Logo
8:49 pm - 2:17 pm
BUF
-
TYS
17h 28m
1 stop
Multiple Airlines Logo
12:55 pm - 10:41 am
TYS
-
BUF
21h 46m
2 stops
$267Multiple Airlines
Thu, May 28 - Mon, Jun 1
Multiple Airlines Logo
7:57 pm - 9:13 pm
BUF
-
TYS
25h 16m
2 stops
Multiple Airlines Logo
10:05 pm - 9:20 pm
TYS
-
BUF
23h 15m
1 stop
$288Multiple Airlines
Sun, Jun 28 - Fri, Jul 3
Multiple Airlines Logo
8:57 pm - 7:05 pm
BUF
-
TYS
22h 08m
1 stop
Multiple Airlines Logo
2:49 pm - 7:07 pm
TYS
-
BUF
28h 18m
1 stop
$298Multiple Airlines
Sun, Aug 23 - Mon, Aug 31
Multiple Airlines Logo
2:50 pm - 9:57 am
BUF
-
TYS
19h 07m
2 stops
Multiple Airlines Logo
10:05 pm - 9:20 pm
TYS
-
BUF
23h 15m
1 stop
$299Multiple Airlines
Fri, Jun 26 - Fri, Jul 3
American Airlines Logo
5:00 am - 10:48 am
BUF
-
TYS
5h 48m
1 stop
American Airlines Logo
5:00 am - 9:03 am
TYS
-
BUF
4h 03m
1 stop
$307American Airlines
Tue, Jun 30 - Tue, Jul 7
American Airlines Logo
12:51 pm - 6:04 pm
BUF
-
TYS
5h 13m
1 stop
American Airlines Logo
11:19 am - 4:17 pm
TYS
-
BUF
4h 58m
1 stop
$309American Airlines
Wed, May 27 - Sat, May 30
American Airlines Logo
12:51 pm - 8:10 pm
BUF
-
TYS
7h 19m
1 stop
American Airlines Logo
3:40 pm - 10:01 pm
TYS
-
BUF
6h 21m
1 stop
$310American Airlines
Thu, May 28 - Sat, May 30

American Airlines flights from Buffalo to Knoxville

Our best American Airlines deals on Buffalo to Knoxville flight tickets
American Airlines
Jun 30
BUF5:00 amBuffalo
5h 48m
1 stop
TYS10:48 amKnoxville McGhee Tyson
Jul 7
TYS5:00 amKnoxville McGhee Tyson
4h 03m
1 stop
BUF9:03 amBuffalo
$307
American Airlines
May 27
BUF12:51 pmBuffalo
5h 13m
1 stop
TYS6:04 pmKnoxville McGhee Tyson
May 30
TYS11:19 amKnoxville McGhee Tyson
4h 58m
1 stop
BUF4:17 pmBuffalo
$309
American Airlines
May 28
BUF12:51 pmBuffalo
7h 19m
1 stop
TYS8:10 pmKnoxville McGhee Tyson
May 30
TYS3:40 pmKnoxville McGhee Tyson
6h 21m
1 stop
BUF10:01 pmBuffalo
$310

United Airlines flights from Buffalo to Knoxville

Our best United Airlines deals on Buffalo to Knoxville flight tickets
United Airlines
Sep 22
BUF7:52 pmBuffalo
4h 05m
1 stop
TYS11:57 pmKnoxville McGhee Tyson
Sep 29
TYS2:00 pmKnoxville McGhee Tyson
9h 26m
2 stops
BUF11:26 pmBuffalo
$324
United Airlines
May 30
BUF6:09 amBuffalo
4h 33m
1 stop
TYS10:42 amKnoxville McGhee Tyson
Jun 3
TYS6:00 amKnoxville McGhee Tyson
8h 25m
2 stops
BUF2:25 pmBuffalo
$434
United Airlines
May 30
BUF10:34 amBuffalo
10h 22m
2 stops
TYS8:56 pmKnoxville McGhee Tyson
Jun 3
TYS6:00 amKnoxville McGhee Tyson
8h 25m
2 stops
BUF2:25 pmBuffalo
$439

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 9, 2026.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sun 8/23

8:57 pm-7:05 pm

1 stop22h 08m

Knoxville McGhee Tyson

Mon 8/31

2:49 pm-10:40 am

2 stops19h 51m

$234

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 6/25

9:02 pm-9:13 pm

1 stop24h 11m

Knoxville McGhee Tyson

Mon 6/29

10:03 pm-10:55 am

2 stops12h 52m

$235

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 6/25

9:02 pm-9:13 pm

1 stop24h 11m

Knoxville McGhee Tyson

Mon 6/29

10:03 pm-7:12 pm

1 stop21h 09m

$255

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 5/28

8:49 pm-2:17 pm

1 stop17h 28m

Knoxville McGhee Tyson

Mon 6/1

12:55 pm-10:41 am

2 stops21h 46m

$267

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sun 6/28

7:57 pm-9:13 pm

2 stops25h 16m

Knoxville McGhee Tyson

Fri 7/3

10:05 pm-9:20 pm

1 stop23h 15m

$288

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sun 8/23

8:57 pm-7:05 pm

1 stop22h 08m

Knoxville McGhee Tyson

Mon 8/31

2:49 pm-7:07 pm

1 stop28h 18m

$298

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Fri 6/26

2:50 pm-9:57 am

2 stops19h 07m

Knoxville McGhee Tyson

Fri 7/3

10:05 pm-9:20 pm

1 stop23h 15m

$299
Quickest round-trip

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Tue 6/30

5:00 am-10:48 am

1 stop5h 48m

Knoxville McGhee Tyson

Tue 7/7

5:00 am-9:03 am

1 stop4h 03m

$307

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 5/27

12:51 pm-6:04 pm

1 stop5h 13m

Knoxville McGhee Tyson

Sat 5/30

11:19 am-4:17 pm

1 stop4h 58m

$309

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 5/28

12:51 pm-8:10 pm

1 stop7h 19m

Knoxville McGhee Tyson

Sat 5/30

3:40 pm-10:01 pm

1 stop6h 21m

$310

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Buffalo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Buffalo and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Buffalo, with most prices found around $281. If you aren’t able to travel during the month of August, then book flights to Knoxville from Buffalo during May instead. Flights to Knoxville in May, while not as cheap as those in August, still average around $303.

When to book flights from Buffalo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Knoxville (BUF to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Knoxville

Fastest flight time

3h 55m

Direct flights

None
The fastest flight from Buffalo to Knoxville takes 3h 55m
There are no direct flights from Buffalo to Knoxville. There are no popular flight routes from Buffalo to Knoxville.
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Frequently asked questions about flying from Buffalo to Knoxville

  • How far is Buffalo to Knoxville McGhee Tyson by plane?

    The distance between Buffalo and Knoxville McGhee Tyson is about 548.4 mi. By plane, this route typically takes 3h 55m.

  • When did momondo last update prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Buffalo Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Buffalo to Knoxville?

Best airlines flying from Buffalo to Knoxville

Compare and see reviews for airlines that fly from Buffalo to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,669 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,457 reviews
Search Delta flights
United AirlinesPriceFrom $283Free CancellationRating
7.4
9,692 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Alcoa
Corbin
Crossville
Maryville
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Buffalo to Knoxville for you.

Can I find flights from Buffalo to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Buffalo to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Buffalo to Knoxville?

momondo helps you find the best flight between Buffalo and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Buffalo to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Buffalo to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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