Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Buffalo to Knoxville from $140

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Knoxville departing on 7/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Buffalo to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:48 pm - 7:39 pm
BUF
-
TYS
28h 51m
2 stops
Multiple Airlines Logo
6:29 pm - 9:23 am
TYS
-
BUF
14h 54m
1 stop
$247Multiple Airlines
Wed, Aug 12 - Mon, Aug 17
Multiple Airlines Logo
2:48 pm - 7:39 pm
BUF
-
TYS
28h 51m
2 stops
Multiple Airlines Logo
6:29 pm - 9:23 am
TYS
-
BUF
14h 54m
1 stop
$251Multiple Airlines
Wed, Aug 12 - Mon, Aug 17
Multiple Airlines Logo
2:48 pm - 7:39 pm
BUF
-
TYS
28h 51m
2 stops
Multiple Airlines Logo
6:29 pm - 9:23 am
TYS
-
BUF
14h 54m
1 stop
$252Multiple Airlines
Wed, Aug 12 - Mon, Aug 17
Multiple Airlines Logo
2:48 pm - 7:39 pm
BUF
-
TYS
28h 51m
2 stops
Multiple Airlines Logo
6:29 pm - 9:23 am
TYS
-
BUF
14h 54m
1 stop
$254Multiple Airlines
Wed, Aug 12 - Mon, Aug 17
Multiple Airlines Logo
2:48 pm - 7:39 pm
BUF
-
TYS
28h 51m
2 stops
Multiple Airlines Logo
6:29 pm - 9:23 am
TYS
-
BUF
14h 54m
1 stop
$261Multiple Airlines
Wed, Aug 12 - Mon, Aug 17
Multiple Airlines Logo
7:57 pm - 3:06 pm
BUF
-
TYS
19h 09m
1 stop
Multiple Airlines Logo
6:29 pm - 9:23 am
TYS
-
BUF
14h 54m
1 stop
$262Multiple Airlines
Wed, Aug 12 - Mon, Aug 17
Multiple Airlines Logo
7:57 pm - 3:06 pm
BUF
-
TYS
19h 09m
1 stop
Multiple Airlines Logo
12:50 pm - 10:29 am
TYS
-
BUF
21h 39m
2 stops
$267Multiple Airlines
Wed, Aug 12 - Mon, Aug 17
Multiple Airlines Logo
7:57 pm - 3:06 pm
BUF
-
TYS
19h 09m
1 stop
Multiple Airlines Logo
12:50 pm - 10:40 am
TYS
-
BUF
21h 50m
2 stops
$270Multiple Airlines
Wed, Aug 12 - Mon, Aug 17
Multiple Airlines Logo
7:57 pm - 3:06 pm
BUF
-
TYS
19h 09m
1 stop
Multiple Airlines Logo
9:08 pm - 9:23 am
TYS
-
BUF
12h 15m
1 stop
$275Multiple Airlines
Wed, Aug 12 - Mon, Aug 17
American Airlines Logo
5:15 am - 10:46 am
BUF
-
TYS
5h 31m
1 stop
American Airlines Logo
4:40 pm - 9:24 pm
TYS
-
BUF
4h 44m
1 stop
$279American Airlines
Sat, Jul 18 - Sat, Jul 25

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

American Airlines flights from Buffalo to Knoxville

Our best American Airlines deals on Buffalo to Knoxville flight tickets
American Airlines
Jul 18
BUF5:15 amBuffalo
5h 31m
1 stop
TYS10:46 amKnoxville McGhee Tyson
Jul 25
TYS4:40 pmKnoxville McGhee Tyson
4h 44m
1 stop
BUF9:24 pmBuffalo
$279
American Airlines
Jul 23
BUF6:00 amBuffalo
5h 45m
1 stop
TYS11:45 amKnoxville McGhee Tyson
Jul 28
TYS6:50 pmKnoxville McGhee Tyson
5h 09m
1 stop
BUF11:59 pmBuffalo
$318
American Airlines
Aug 12
BUF5:38 pmBuffalo
3h 56m
1 stop
TYS9:34 pmKnoxville McGhee Tyson
Aug 17
TYS6:57 amKnoxville McGhee Tyson
5h 41m
1 stop
BUF12:38 pmBuffalo
$319

Southwest flights from Buffalo to Knoxville

Our best Southwest deals on Buffalo to Knoxville flight tickets
Southwest
Aug 29
BUF3:30 pmBuffalo
3h 50m
1 stop
TYS7:20 pmKnoxville McGhee Tyson
Sep 5
TYS6:50 amKnoxville McGhee Tyson
9h 10m
1 stop
BUF4:00 pmBuffalo
$284
Southwest
Aug 29
BUF5:45 amBuffalo
8h 55m
2 stops
TYS2:40 pmKnoxville McGhee Tyson
Sep 5
TYS6:50 amKnoxville McGhee Tyson
9h 10m
1 stop
BUF4:00 pmBuffalo
$290
Southwest
Aug 16
BUF6:45 amBuffalo
8h 15m
1 stop
TYS3:00 pmKnoxville McGhee Tyson
Aug 19
TYS8:05 amKnoxville McGhee Tyson
4h 25m
1 stop
BUF12:30 pmBuffalo
$328

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 21, 2026.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 8/12

2:48 pm-7:39 pm

2 stops28h 51m

Knoxville McGhee Tyson

Mon 8/17

6:29 pm-9:23 am

1 stop14h 54m

$247

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 8/12

2:48 pm-7:39 pm

2 stops28h 51m

Knoxville McGhee Tyson

Mon 8/17

6:29 pm-9:23 am

1 stop14h 54m

$251

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 8/12

2:48 pm-7:39 pm

2 stops28h 51m

Knoxville McGhee Tyson

Mon 8/17

6:29 pm-9:23 am

1 stop14h 54m

$252

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 8/12

2:48 pm-7:39 pm

2 stops28h 51m

Knoxville McGhee Tyson

Mon 8/17

6:29 pm-9:23 am

1 stop14h 54m

$254

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 8/12

2:48 pm-7:39 pm

2 stops28h 51m

Knoxville McGhee Tyson

Mon 8/17

6:29 pm-9:23 am

1 stop14h 54m

$261

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 8/12

7:57 pm-3:06 pm

1 stop19h 09m

Knoxville McGhee Tyson

Mon 8/17

6:29 pm-9:23 am

1 stop14h 54m

$262

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 8/12

7:57 pm-3:06 pm

1 stop19h 09m

Knoxville McGhee Tyson

Mon 8/17

12:50 pm-10:29 am

2 stops21h 39m

$267

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 8/12

7:57 pm-3:06 pm

1 stop19h 09m

Knoxville McGhee Tyson

Mon 8/17

12:50 pm-10:40 am

2 stops21h 50m

$270

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 8/12

7:57 pm-3:06 pm

1 stop19h 09m

Knoxville McGhee Tyson

Mon 8/17

9:08 pm-9:23 am

1 stop12h 15m

$275
Quickest round-trip

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sat 7/18

5:15 am-10:46 am

1 stop5h 31m

Knoxville McGhee Tyson

Sat 7/25

4:40 pm-9:24 pm

1 stop4h 44m

$279

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Knoxville from

How to get the cheapest flight ticket from Buffalo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Buffalo and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Buffalo, with most prices found around $338. If you aren’t able to travel during the month of August, then book flights to Knoxville from Buffalo during June instead. Flights to Knoxville in June, while not as cheap as those in August, still average around $344.

When to book flights from Buffalo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Knoxville (BUF to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Knoxville

Fastest flight time

4h 06m

Direct flights

None
The fastest flight from Buffalo to Knoxville takes 4h 06m
There are no direct flights from Buffalo to Knoxville. There are no popular flight routes from Buffalo to Knoxville.
Search flight deals

Frequently asked questions about flying from Buffalo to Knoxville

  • How far is Buffalo to Knoxville McGhee Tyson by plane?

    The distance between Buffalo and Knoxville McGhee Tyson is about 548.4 mi. By plane, this route typically takes 4h 06m.

  • When did momondo last update prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Buffalo Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Buffalo to Knoxville?

Best airlines flying from Buffalo to Knoxville

Compare and see reviews for airlines that fly from Buffalo to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,722 reviews
Search American Airlines flights
DeltaPriceFrom $250Free CancellationRating
7.8
8,423 reviews
Search Delta flights
United AirlinesPriceFrom $346Free CancellationRating
7.4
9,868 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Lenoir City
Kodak
Newport
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Buffalo to Knoxville for you.

Can I find flights from Buffalo to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Buffalo to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Buffalo to Knoxville?

momondo helps you find the best flight between Buffalo and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Buffalo to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Buffalo to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Tue 7/21
Tue 7/28
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States