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Cheap flights from Buffalo to Knoxville from $127

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Knoxville departing on 5/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Buffalo to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:16 pm - 9:40 am
BUF
-
TYS
13h 24m
1 stop
Multiple Airlines Logo
6:20 pm - 12:42 pm
TYS
-
BUF
42h 22m
2 stops
$282Multiple Airlines
Mon, Apr 13 - Mon, Apr 20
Multiple Airlines Logo
11:19 am - 5:30 pm
BUF
-
TYS
6h 11m
1 stop
Multiple Airlines Logo
9:25 pm - 11:23 am
TYS
-
BUF
13h 58m
2 stops
$297Multiple Airlines
Mon, Apr 27 - Thu, Apr 30
Multiple Airlines Logo
11:19 am - 5:30 pm
BUF
-
TYS
6h 11m
1 stop
Multiple Airlines Logo
9:25 pm - 11:23 am
TYS
-
BUF
13h 58m
2 stops
$305Multiple Airlines
Mon, Apr 27 - Thu, Apr 30
Multiple Airlines Logo
7:52 pm - 3:55 pm
BUF
-
TYS
20h 03m
1 stop
Multiple Airlines Logo
7:26 pm - 7:07 pm
TYS
-
BUF
23h 41m
1 stop
$310Multiple Airlines
Mon, Jun 15 - Mon, Jun 22
Multiple Airlines Logo
7:52 pm - 3:55 pm
BUF
-
TYS
20h 03m
1 stop
Multiple Airlines Logo
7:26 pm - 7:07 pm
TYS
-
BUF
23h 41m
1 stop
$321Multiple Airlines
Mon, Jun 15 - Mon, Jun 22
Multiple Airlines Logo
7:52 pm - 4:12 pm
BUF
-
TYS
20h 20m
2 stops
Multiple Airlines Logo
7:26 pm - 7:07 pm
TYS
-
BUF
23h 41m
1 stop
$325Multiple Airlines
Mon, Jun 15 - Mon, Jun 22
American Airlines Logo
7:31 pm - 11:47 pm
BUF
-
TYS
4h 16m
1 stop
American Airlines Logo
6:53 pm - 11:56 pm
TYS
-
BUF
5h 03m
1 stop
$326American Airlines
Tue, Jun 9 - Tue, Jun 16
Multiple Airlines Logo
7:52 pm - 4:12 pm
BUF
-
TYS
20h 20m
2 stops
Multiple Airlines Logo
7:26 pm - 7:07 pm
TYS
-
BUF
23h 41m
1 stop
$340Multiple Airlines
Mon, Jun 15 - Mon, Jun 22
Multiple Airlines Logo
7:52 pm - 4:12 pm
BUF
-
TYS
20h 20m
2 stops
Multiple Airlines Logo
7:26 pm - 7:07 pm
TYS
-
BUF
23h 41m
1 stop
$341Multiple Airlines
Mon, Jun 15 - Mon, Jun 22
Multiple Airlines Logo
8:16 pm - 9:40 am
BUF
-
TYS
13h 24m
1 stop
Multiple Airlines Logo
1:15 pm - 7:26 pm
TYS
-
BUF
6h 11m
1 stop
$344Multiple Airlines
Mon, Apr 13 - Mon, Apr 20

American Airlines flights from Buffalo to Knoxville

Our best American Airlines deals on Buffalo to Knoxville flight tickets
American Airlines
Jun 9
BUF7:31 pmBuffalo
4h 16m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
Jun 16
TYS6:53 pmKnoxville McGhee Tyson
5h 03m
1 stop
BUF11:56 pmBuffalo
$326
American Airlines
Apr 27
BUF5:30 amBuffalo
5h 31m
1 stop
TYS11:01 amKnoxville McGhee Tyson
Apr 30
TYS5:00 amKnoxville McGhee Tyson
6h 58m
2 stops
BUF11:58 amBuffalo
$372
American Airlines
Apr 10
BUF7:28 pmBuffalo
4h 31m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Apr 18
TYS2:06 pmKnoxville McGhee Tyson
4h 32m
1 stop
BUF6:38 pmBuffalo
$377

Southwest flights from Buffalo to Knoxville

Our best Southwest deals on Buffalo to Knoxville flight tickets
Southwest
Apr 27
BUF5:20 pmBuffalo
3h 55m
1 stop
TYS9:15 pmKnoxville McGhee Tyson
Apr 30
TYS8:05 amKnoxville McGhee Tyson
3h 55m
1 stop
BUF12:00 pmBuffalo
$357
Southwest
Apr 8
BUF11:55 amBuffalo
5h 15m
1 stop
TYS5:10 pmKnoxville McGhee Tyson
Apr 15
TYS8:15 amKnoxville McGhee Tyson
6h 20m
1 stop
BUF2:35 pmBuffalo
$366
Southwest
Apr 8
BUF4:00 pmBuffalo
4h 50m
1 stop
TYS8:50 pmKnoxville McGhee Tyson
Apr 15
TYS7:05 amKnoxville McGhee Tyson
7h 30m
2 stops
BUF2:35 pmBuffalo
$371

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 4/13

8:16 pm-9:40 am

1 stop13h 24m

Knoxville McGhee Tyson

Mon 4/20

6:20 pm-12:42 pm

2 stops42h 22m

$282

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 4/27

11:19 am-5:30 pm

1 stop6h 11m

Knoxville McGhee Tyson

Thu 4/30

9:25 pm-11:23 am

2 stops13h 58m

$297

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 4/27

11:19 am-5:30 pm

1 stop6h 11m

Knoxville McGhee Tyson

Thu 4/30

9:25 pm-11:23 am

2 stops13h 58m

$305

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 6/15

7:52 pm-3:55 pm

1 stop20h 03m

Knoxville McGhee Tyson

Mon 6/22

7:26 pm-7:07 pm

1 stop23h 41m

$310

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 6/15

7:52 pm-3:55 pm

1 stop20h 03m

Knoxville McGhee Tyson

Mon 6/22

7:26 pm-7:07 pm

1 stop23h 41m

$321

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 6/15

7:52 pm-4:12 pm

2 stops20h 20m

Knoxville McGhee Tyson

Mon 6/22

7:26 pm-7:07 pm

1 stop23h 41m

$325
Quickest round-trip

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Tue 6/9

7:31 pm-11:47 pm

1 stop4h 16m

Knoxville McGhee Tyson

Tue 6/16

6:53 pm-11:56 pm

1 stop5h 03m

$326

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 6/15

7:52 pm-4:12 pm

2 stops20h 20m

Knoxville McGhee Tyson

Mon 6/22

7:26 pm-7:07 pm

1 stop23h 41m

$340

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 6/15

7:52 pm-4:12 pm

2 stops20h 20m

Knoxville McGhee Tyson

Mon 6/22

7:26 pm-7:07 pm

1 stop23h 41m

$341

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 4/13

8:16 pm-9:40 am

1 stop13h 24m

Knoxville McGhee Tyson

Mon 4/20

1:15 pm-7:26 pm

1 stop6h 11m

$344

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Buffalo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Buffalo, with most prices found around $281. If you aren’t able to travel during the month of August, then book flights to Knoxville from Buffalo during March instead. Flights to Knoxville in March, while not as cheap as those in August, still average around $283.

How have Buffalo to Knoxville flight prices changed over time?

When to book flights from Buffalo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Knoxville (BUF to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Knoxville

Fastest flight time

3h 56m

Direct flights

None
The fastest flight from Buffalo to Knoxville takes 3h 56m
There are no direct flights from Buffalo to Knoxville. There are no popular flight routes from Buffalo to Knoxville.
Search flight deals

  • How far is Buffalo to Knoxville McGhee Tyson by plane?

    The distance between Buffalo and Knoxville McGhee Tyson is about 548.4 mi. By plane, this route typically takes 3h 56m.

  • When did momondo last update prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Buffalo Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Buffalo to Knoxville?

Best airlines flying from Buffalo to Knoxville

Compare and see reviews for airlines that fly from Buffalo to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $239Free CancellationRating
7.9
8,320 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,492 reviews
Search American Airlines flights
United AirlinesPriceFrom $346Free CancellationRating
7.4
9,467 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Buffalo to Knoxville for you.

Can I find flights from Buffalo to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Buffalo to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Buffalo to Knoxville?

momondo helps you find the best flight between Buffalo and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Buffalo to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Buffalo to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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