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Cheap flights from Buffalo to Knoxville from $155

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Knoxville departing on 9/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Buffalo to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:51 pm - 10:41 pm-
27h 50m
Multiple Airlines Logo
9:25 pm - 12:18 pm-
38h 53m
$287Multiple Airlines
Tue, Oct 6 - Mon, Oct 12
Southwest Logo
3:30 pm - 7:25 pm-
3h 55m
Southwest Logo
6:50 am - 3:40 pm-
8h 50m
$318Southwest
Sat, Sep 19 - Sat, Sep 26
Delta Logo
3:53 pm - 9:44 pm-
5h 51m
Delta Logo
7:33 am - 11:22 am-
3h 49m
$329Delta
Mon, Sep 14 - Tue, Sep 22
Delta Logo
6:00 am - 10:20 am-
4h 20m
Delta Logo
7:10 am - 11:23 am-
4h 13m
$329Delta
Sat, Dec 5 - Sat, Dec 12
United Airlines Logo
7:00 am - 1:18 pm-
6h 18m
United Airlines Logo
1:55 pm - 8:47 pm-
6h 52m
$329United Airlines
Sat, Sep 19 - Sat, Sep 26
Southwest Logo
7:50 am - 7:25 pm-
11h 35m
Southwest Logo
6:50 am - 3:40 pm-
8h 50m
$329Southwest
Sat, Sep 19 - Sat, Sep 26
United Airlines Logo
10:30 am - 4:58 pm-
6h 28m
United Airlines Logo
6:00 am - 2:18 pm-
8h 18m
$334United Airlines
Mon, Sep 14 - Tue, Sep 22
American Airlines Logo
6:59 pm - 10:58 pm-
3h 59m
American Airlines Logo
6:57 am - 12:38 pm-
5h 41m
$339American Airlines
Mon, Aug 31 - Mon, Sep 7
American Airlines Logo
2:51 pm - 8:07 pm-
5h 16m
American Airlines Logo
6:57 am - 12:38 pm-
5h 41m
$339American Airlines
Fri, Sep 4 - Mon, Sep 7
United Airlines Logo
10:30 am - 4:58 pm-
6h 28m
United Airlines Logo
7:20 pm - 11:44 pm-
4h 24m
$347United Airlines
Sun, Aug 30 - Sun, Sep 6

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Delta flights from Buffalo to Knoxville

Our best Delta deals on Buffalo to Knoxville flight tickets
Delta
Sep 17
BUF6:59 pmBuffalo
4h 56m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
Sep 20
TYS5:40 amKnoxville McGhee Tyson
5h 30m
1 stop
BUF11:10 amBuffalo
$348
Delta
Sep 18
BUF6:59 pmBuffalo
4h 56m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
Sep 20
TYS5:40 amKnoxville McGhee Tyson
5h 30m
1 stop
BUF11:10 amBuffalo
$358

United Airlines flights from Buffalo to Knoxville

Our best United Airlines deals on Buffalo to Knoxville flight tickets
United Airlines
Sep 14
BUF10:30 amBuffalo
6h 28m
1 stop
TYS4:58 pmKnoxville McGhee Tyson
Sep 22
TYS6:00 amKnoxville McGhee Tyson
8h 18m
2 stops
BUF2:18 pmBuffalo
$334
United Airlines
Aug 30
BUF10:30 amBuffalo
6h 28m
1 stop
TYS4:58 pmKnoxville McGhee Tyson
Sep 6
TYS7:20 pmKnoxville McGhee Tyson
4h 24m
1 stop
BUF11:44 pmBuffalo
$347
United Airlines
Aug 26
BUF1:56 pmBuffalo
6h 57m
1 stop
TYS8:53 pmKnoxville McGhee Tyson
Aug 29
TYS7:00 amKnoxville McGhee Tyson
6h 16m
1 stop
BUF1:16 pmBuffalo
$367

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 5, 2026.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Tue 10/6

6:51 pm-10:41 pm

1 stop27h 50m

Knoxville McGhee Tyson

Mon 10/12

9:25 pm-12:18 pm

2 stops38h 53m

$287

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sat 9/19

3:30 pm-7:25 pm

1 stop3h 55m

Knoxville McGhee Tyson

Sat 9/26

6:50 am-3:40 pm

1 stop8h 50m

$318

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 9/14

3:53 pm-9:44 pm

1 stop5h 51m

Knoxville McGhee Tyson

Tue 9/22

7:33 am-11:22 am

1 stop3h 49m

$329
Quickest round-trip

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sat 12/5

6:00 am-10:20 am

1 stop4h 20m

Knoxville McGhee Tyson

Sat 12/12

7:10 am-11:23 am

1 stop4h 13m

$329

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sat 9/19

7:00 am-1:18 pm

1 stop6h 18m

Knoxville McGhee Tyson

Sat 9/26

1:55 pm-8:47 pm

1 stop6h 52m

$329

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sat 9/19

7:50 am-7:25 pm

2 stops11h 35m

Knoxville McGhee Tyson

Sat 9/26

6:50 am-3:40 pm

1 stop8h 50m

$329

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 9/14

10:30 am-4:58 pm

1 stop6h 28m

Knoxville McGhee Tyson

Tue 9/22

6:00 am-2:18 pm

2 stops8h 18m

$334

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 8/31

6:59 pm-10:58 pm

1 stop3h 59m

Knoxville McGhee Tyson

Mon 9/7

6:57 am-12:38 pm

1 stop5h 41m

$339

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Fri 9/4

2:51 pm-8:07 pm

1 stop5h 16m

Knoxville McGhee Tyson

Mon 9/7

6:57 am-12:38 pm

1 stop5h 41m

$339

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sun 8/30

10:30 am-4:58 pm

1 stop6h 28m

Knoxville McGhee Tyson

Sun 9/6

7:20 pm-11:44 pm

1 stop4h 24m

$347

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Buffalo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Buffalo and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $338 to $401.
The lowest price recently found on this route was $287.

What is the cheapest month to fly to Knoxville?

The month of June is, on average, the cheapest month to fly to Knoxville from Buffalo, with most prices found around $344. If you aren’t able to travel during the month of June, then book flights to Knoxville from Buffalo during November instead. Flights to Knoxville in November, while not as cheap as those in June, still average around $350.

When to book flights from Buffalo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Knoxville (BUF to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Knoxville

Fastest flight time

4h 00m

Direct flights

None
The fastest flight from Buffalo to Knoxville takes 4h 00m
There are no direct flights from Buffalo to Knoxville. There are no popular flight routes from Buffalo to Knoxville.
Search flight deals

Frequently asked questions about flying from Buffalo to Knoxville

  • How far is Buffalo to Knoxville McGhee Tyson by plane?

    The distance between Buffalo and Knoxville McGhee Tyson is about 548.4 mi. By plane, this route typically takes 4h 00m.

  • When did momondo last update prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Buffalo Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Buffalo to Knoxville?

Best airlines flying from Buffalo to Knoxville

Compare and see reviews for airlines that fly from Buffalo to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $248Free CancellationRating
7.8
8,483 reviews
Search Delta flights
American AirlinesPriceFrom $268Free CancellationRating
7.1
11,845 reviews
Search American Airlines flights
United AirlinesPriceFrom $346Free CancellationRating
7.4
10,059 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Buffalo to Knoxville for you.

Can I find flights from Buffalo to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Buffalo to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Buffalo to Knoxville?

momondo helps you find the best flight between Buffalo and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Buffalo to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Buffalo to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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