What airlines fly to Knoxville?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Knoxville from Buffalo according to our data. American Airlines is the first choice among our users, with 69% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 3 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Buffalo to Knoxville McGhee Tyson?

Delta, American Airlines, and United Airlines are the most popular carriers operating from Buffalo to Knoxville McGhee Tyson

When did momondo last update prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?

Prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport refresh daily.

How many operators does momondo search for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?

As of November 2025, there are 3 operators available to choose from for flights from Buffalo Airport to Knoxville McGhee Tyson Airport.

How old do you have to be to fly from Buffalo Airport to Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$100 Cheap Flights from Buffalo to Knoxville in 2025/26

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6:59 pm - 1:57 pmBUF-TYS

18h 58m1 stop

6:30 am - 2:43 pmTYS-BUF

32h 13m2 stops

$239Multiple Airlines

Find Deal

Sun, Nov 16 - Thu, Nov 20

12:10 pm - 4:53 pmBUF-TYS

4h 43m1 stop

7:39 am - 12:34 pmTYS-BUF

4h 55m1 stop

$277Delta

Find Deal

Wed, Dec 3 - Tue, Dec 9

6:00 am - 5:11 pmBUF-TYS

11h 11m2 stops

9:40 am - 2:22 pmTYS-BUF

4h 42m1 stop

$282United Airlines

Find Deal

Wed, Dec 3 - Tue, Dec 9

6:33 pm - 10:51 pmBUF-TYS

4h 18m1 stop

6:12 am - 12:01 pmTYS-BUF

5h 49m1 stop

$376American Airlines

Find Deal

Wed, Nov 19 - Mon, Nov 24

7:30 pm - 11:59 pmBUF-TYS

4h 29m1 stop

7:00 am - 1:12 pmTYS-BUF

6h 12m1 stop

$382United Airlines

Find Deal

Mon, Dec 1 - Mon, Dec 8

12:05 pm - 4:51 pmBUF-TYS

4h 46m1 stop

5:35 am - 11:00 amTYS-BUF

5h 25m1 stop

$417Delta

Find Deal

Sun, Nov 16 - Thu, Nov 20

11:39 am - 6:55 pmBUF-TYS

7h 16m2 stops

10:20 am - 4:49 pmTYS-BUF

6h 29m2 stops

$427American Airlines

Find Deal

Wed, Dec 3 - Tue, Dec 9

6:00 am - 5:08 pmBUF-TYS

11h 08m2 stops

6:45 am - 1:17 pmTYS-BUF

6h 32m1 stop

$452United Airlines

Find Deal

Wed, Nov 19 - Mon, Nov 24

2:58 pm - 9:21 pmBUF-TYS

6h 23m1 stop

6:06 am - 12:13 pmTYS-BUF

6h 07m1 stop

$467American Airlines

Find Deal

Wed, Nov 26 - Sat, Nov 29

7:30 pm - 11:59 pmBUF-TYS

4h 29m1 stop

5:45 am - 9:48 amTYS-BUF

4h 03m1 stop

$487United Airlines

Find Deal

Mon, Nov 17 - Fri, Nov 21

American Airlines flights from Buffalo to Knoxville

Our best American Airlines deals on Buffalo to Knoxville flight tickets

American Airlines

Nov 19

BUF6:33 pmBuffalo

4h 18m

1 stop

TYS10:51 pmKnoxville McGhee Tyson

Nov 24

TYS6:12 amKnoxville McGhee Tyson

5h 49m

1 stop

BUF12:01 pmBuffalo

$376

Find similar

American Airlines

Dec 3

BUF11:39 amBuffalo

7h 16m

2 stops

TYS6:55 pmKnoxville McGhee Tyson

Dec 9

TYS10:20 amKnoxville McGhee Tyson

6h 29m

2 stops

BUF4:49 pmBuffalo

$427

Find similar

American Airlines

Nov 26

BUF2:58 pmBuffalo

6h 23m

1 stop

TYS9:21 pmKnoxville McGhee Tyson

Nov 29

TYS6:06 amKnoxville McGhee Tyson

6h 07m

1 stop

BUF12:13 pmBuffalo

$467

Find similar

United Airlines flights from Buffalo to Knoxville

Our best United Airlines deals on Buffalo to Knoxville flight tickets

United Airlines

Dec 3

BUF6:00 amBuffalo

11h 11m

2 stops

TYS5:11 pmKnoxville McGhee Tyson

Dec 9

TYS9:40 amKnoxville McGhee Tyson

4h 42m

1 stop

BUF2:22 pmBuffalo

$282

Find similar

United Airlines

Dec 1

BUF7:30 pmBuffalo

4h 29m

1 stop

TYS11:59 pmKnoxville McGhee Tyson

Dec 8

TYS7:00 amKnoxville McGhee Tyson

6h 12m

1 stop

BUF1:12 pmBuffalo

$382

Find similar

United Airlines

Nov 19

BUF6:00 amBuffalo

11h 08m

2 stops

TYS5:08 pmKnoxville McGhee Tyson

Nov 24

TYS6:45 amKnoxville McGhee Tyson

6h 32m

1 stop

BUF1:17 pmBuffalo

$452

Find similar

Fly from

Fly to

Route

Depart

Return

Price

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sun 11/16

6:59 pm-1:57 pm

1 stop18h 58m

Knoxville McGhee Tyson

Thu 11/20

6:30 am-2:43 pm

2 stops32h 13m

$239

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 12/3

12:10 pm-4:53 pm

1 stop4h 43m

Knoxville McGhee Tyson

Tue 12/9

7:39 am-12:34 pm

1 stop4h 55m

$277

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 12/3

6:00 am-5:11 pm

2 stops11h 11m

Knoxville McGhee Tyson

Tue 12/9

9:40 am-2:22 pm

1 stop4h 42m

$282

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 11/19

6:33 pm-10:51 pm

1 stop4h 18m

Knoxville McGhee Tyson

Mon 11/24

6:12 am-12:01 pm

1 stop5h 49m

$376

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 12/1

7:30 pm-11:59 pm

1 stop4h 29m

Knoxville McGhee Tyson

Mon 12/8

7:00 am-1:12 pm

1 stop6h 12m

$382

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sun 11/16

12:05 pm-4:51 pm

1 stop4h 46m

Knoxville McGhee Tyson

Thu 11/20

5:35 am-11:00 am

1 stop5h 25m

$417

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 12/3

11:39 am-6:55 pm

2 stops7h 16m

Knoxville McGhee Tyson

Tue 12/9

10:20 am-4:49 pm

2 stops6h 29m

$427

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 11/19

6:00 am-5:08 pm

2 stops11h 08m

Knoxville McGhee Tyson

Mon 11/24

6:45 am-1:17 pm

1 stop6h 32m

$452

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 11/26

2:58 pm-9:21 pm

1 stop6h 23m

Knoxville McGhee Tyson

Sat 11/29

6:06 am-12:13 pm

1 stop6h 07m

$467

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 11/17

7:30 pm-11:59 pm

1 stop4h 29m

Knoxville McGhee Tyson

Fri 11/21

5:45 am-9:48 am

1 stop4h 03m

$487

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Buffalo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Knoxville?

The month of February is, on average, the cheapest month to fly to Knoxville from Buffalo, with most prices found around $278. If you aren’t able to travel during the month of February, then book flights to Knoxville from Buffalo during May instead. Flights to Knoxville in May, while not as cheap as those in February, still average around $303.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Buffalo to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $282. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Buffalo to Knoxville for around $494.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Buffalo to Knoxville when you can find flight prices for as low as $272. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $381.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Buffalo when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $343 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Buffalo for as low as $266 on momondo.

How have Buffalo to Knoxville flight prices changed over time?

When to book flights from Buffalo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Buffalo to Knoxville (BUF to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Knoxville

Direct flights	None

There are no direct flights from Buffalo to Knoxville. There are no popular flight routes from Buffalo to Knoxville.

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How far is Buffalo to Knoxville McGhee Tyson by plane?
The distance between Buffalo and Knoxville McGhee Tyson is about 548.4 mi. By plane, this route typically takes 4h 06m.
When did momondo last update prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport refresh daily.
How many operators does momondo search for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?
As of November 2025, there are 3 operators available to choose from for flights from Buffalo Airport to Knoxville McGhee Tyson Airport.
How old do you have to be to fly from Buffalo Airport to Knoxville McGhee Tyson Airport?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Buffalo to Knoxville?
Based on momondo bookings for flights between Buffalo and Knoxville, the leading airline is American Airlines, making up 75% of the total bookings. Other popular airlines include Delta with 14% and United Airlines with 11%.

Best airlines flying from Buffalo to Knoxville

Compare and see reviews for airlines that fly from Buffalo to Knoxville with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $224	Free Cancellation	Rating 7.4 8,997 reviews	Search United Airlines flights
Delta	PriceFrom $232	Free Cancellation	Rating 7.9 8,002 reviews	Search Delta flights
American Airlines	PriceFrom $248	Free Cancellation	Rating 7.2 11,038 reviews	Search American Airlines flights

Pigeon Forge

Gatlinburg

Cherokee

Bryson City

Morristown

Corbin

Crossville

Maryville

Murphy

Alcoa

Oak Ridge

Lenoir City

Newport

Kodak

Dandridge

Clinton

Jefferson City

Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Buffalo to Knoxville for you.

Can I find flights from Buffalo to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Buffalo to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Buffalo to Knoxville?

momondo helps you find the best flight between Buffalo and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Buffalo to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Buffalo to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.