What is the cheapest airline that flies from Buffalo to Knoxville McGhee Tyson?

Delta, American Airlines, and United Airlines are the most popular carriers operating from Buffalo to Knoxville McGhee Tyson

What airlines fly to Knoxville?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Knoxville from Buffalo according to our data. American Airlines is the first choice among our users, with 68% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 3 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?

Prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport refresh daily.

How many operators does momondo search for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?

As of December 2025, there are 3 operators available to choose from for flights from Buffalo Airport to Knoxville McGhee Tyson Airport.

How old do you have to be to fly from Buffalo Airport to Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$201 Cheap Flights from Buffalo to Knoxville in 2025/26

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Find the cheapest flights from Buffalo to Knoxville

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Cheap round-trip flights

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6:15 am - 12:11 pm

BUF

TYS

5h 56m1 stop

1:30 pm - 4:59 pm

TYS

BUF

3h 29m1 stop

$277Delta

Wed, Feb 25 - Sat, Feb 28

7:00 am - 1:15 pm

BUF

TYS

6h 15m1 stop

1:50 pm - 11:44 pm

TYS

BUF

9h 54m2 stops

$282United Airlines

Wed, Feb 25 - Sat, Feb 28

5:24 pm - 9:52 pm

BUF

TYS

4h 28m1 stop

6:40 am - 10:59 am

TYS

BUF

4h 19m1 stop

$286American Airlines

Mon, Feb 16 - Wed, Feb 18

6:38 pm - 10:54 pm

BUF

TYS

4h 16m1 stop

6:40 am - 10:59 am

TYS

BUF

4h 19m1 stop

$287American Airlines

Tue, Feb 17 - Thu, Feb 19

6:46 am - 3:41 pm

BUF

TYS

8h 55m2 stops

6:40 am - 10:59 am

TYS

BUF

4h 19m1 stop

$292American Airlines

Tue, Feb 17 - Thu, Feb 19

1:00 pm - 4:43 pm

BUF

TYS

3h 43m1 stop

5:24 pm - 10:55 pm

TYS

BUF

5h 31m1 stop

$337Delta

Fri, Mar 20 - Thu, Mar 26

7:40 pm - 11:40 pm

BUF

TYS

4h 00m1 stop

5:00 am - 12:14 pm

TYS

BUF

7h 14m2 stops

$342American Airlines

Fri, Mar 20 - Thu, Mar 26

1:59 pm - 8:52 pm

BUF

TYS

6h 53m1 stop

1:59 pm - 8:29 pm

TYS

BUF

6h 30m1 stop

$347United Airlines

Wed, Jan 28 - Sat, Jan 31

11:24 am - 7:27 pm

BUF

TYS

8h 03m2 stops

1:59 pm - 8:29 pm

TYS

BUF

6h 30m1 stop

$352United Airlines

Wed, Jan 28 - Sat, Jan 31

11:24 am - 8:52 pm

BUF

TYS

9h 28m2 stops

1:59 pm - 10:31 pm

TYS

BUF

8h 32m2 stops

$357United Airlines

Wed, Jan 28 - Sat, Jan 31

Southwest flights from Buffalo to Knoxville

Our best Southwest deals on Buffalo to Knoxville flight tickets

Southwest

Apr 4

BUF5:50 pmBuffalo

4h 20m

1 stop

TYS10:10 pmKnoxville McGhee Tyson

Apr 11

TYS6:40 amKnoxville McGhee Tyson

7h 35m

1 stop

BUF2:15 pmBuffalo

$487

Find similar

Southwest

Apr 4

BUF5:15 amBuffalo

7h 55m

2 stops

TYS1:10 pmKnoxville McGhee Tyson

Apr 11

TYS6:40 amKnoxville McGhee Tyson

9h 35m

2 stops

BUF4:15 pmBuffalo

$552

Find similar

Southwest

Apr 3

BUF3:55 pmBuffalo

6h 15m

1 stop

TYS10:10 pmKnoxville McGhee Tyson

Apr 11

TYS6:40 amKnoxville McGhee Tyson

7h 35m

1 stop

BUF2:15 pmBuffalo

$577

Find similar

Delta flights from Buffalo to Knoxville

Our best Delta deals on Buffalo to Knoxville flight tickets

Delta

Feb 25

BUF6:15 amBuffalo

5h 56m

1 stop

TYS12:11 pmKnoxville McGhee Tyson

Feb 28

TYS1:30 pmKnoxville McGhee Tyson

3h 29m

1 stop

BUF4:59 pmBuffalo

$277

Find similar

Delta

Mar 20

BUF1:00 pmBuffalo

3h 43m

1 stop

TYS4:43 pmKnoxville McGhee Tyson

Mar 26

TYS5:24 pmKnoxville McGhee Tyson

5h 31m

1 stop

BUF10:55 pmBuffalo

$337

Find similar

Fly from

Fly to

Route

Depart

Return

Price

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 2/25

6:15 am-12:11 pm

1 stop5h 56m

Knoxville McGhee Tyson

Sat 2/28

1:30 pm-4:59 pm

1 stop3h 29m

$277

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 2/25

7:00 am-1:15 pm

1 stop6h 15m

Knoxville McGhee Tyson

Sat 2/28

1:50 pm-11:44 pm

2 stops9h 54m

$282

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Mon 2/16

5:24 pm-9:52 pm

1 stop4h 28m

Knoxville McGhee Tyson

Wed 2/18

6:40 am-10:59 am

1 stop4h 19m

$286

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Tue 2/17

6:38 pm-10:54 pm

1 stop4h 16m

Knoxville McGhee Tyson

Thu 2/19

6:40 am-10:59 am

1 stop4h 19m

$287

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Tue 2/17

6:46 am-3:41 pm

2 stops8h 55m

Knoxville McGhee Tyson

Thu 2/19

6:40 am-10:59 am

1 stop4h 19m

$292

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Fri 3/20

1:00 pm-4:43 pm

1 stop3h 43m

Knoxville McGhee Tyson

Thu 3/26

5:24 pm-10:55 pm

1 stop5h 31m

$337

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Fri 3/20

7:40 pm-11:40 pm

1 stop4h 00m

Knoxville McGhee Tyson

Thu 3/26

5:00 am-12:14 pm

2 stops7h 14m

$342

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 1/28

1:59 pm-8:52 pm

1 stop6h 53m

Knoxville McGhee Tyson

Sat 1/31

1:59 pm-8:29 pm

1 stop6h 30m

$347

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 1/28

11:24 am-7:27 pm

2 stops8h 03m

Knoxville McGhee Tyson

Sat 1/31

1:59 pm-8:29 pm

1 stop6h 30m

$352

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 1/28

11:24 am-8:52 pm

2 stops9h 28m

Knoxville McGhee Tyson

Sat 1/31

1:59 pm-10:31 pm

2 stops8h 32m

$357

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first

How to get the cheapest flight ticket from Buffalo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Knoxville?

The month of March is, on average, the cheapest month to fly to Knoxville from Buffalo, with most prices found around $283. If you aren’t able to travel during the month of March, then book flights to Knoxville from Buffalo during May instead. Flights to Knoxville in May, while not as cheap as those in March, still average around $303.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Buffalo to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $282. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Buffalo to Knoxville for around $494.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Buffalo to Knoxville when you can find flight prices for as low as $272. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $381.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Buffalo when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $349 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Buffalo for as low as $266 on momondo.

How have Buffalo to Knoxville flight prices changed over time?

When to book flights from Buffalo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Buffalo to Knoxville (BUF to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Knoxville

Fastest flight time	4h 20m
Direct flights	None

The fastest flight from Buffalo to Knoxville takes 4h 20m

There are no direct flights from Buffalo to Knoxville. There are no popular flight routes from Buffalo to Knoxville.

Search flight deals

How far is Buffalo to Knoxville McGhee Tyson by plane?
The distance between Buffalo and Knoxville McGhee Tyson is about 548.4 mi. By plane, this route typically takes 4h 20m.
When did momondo last update prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport refresh daily.
How many operators does momondo search for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?
As of December 2025, there are 3 operators available to choose from for flights from Buffalo Airport to Knoxville McGhee Tyson Airport.
How old do you have to be to fly from Buffalo Airport to Knoxville McGhee Tyson Airport?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Buffalo to Knoxville?
Based on momondo bookings for flights between Buffalo and Knoxville, the leading airline is American Airlines, making up 74% of the total bookings. Other popular airlines include Delta with 14% and United Airlines with 12%.

Best airlines flying from Buffalo to Knoxville

Compare and see reviews for airlines that fly from Buffalo to Knoxville with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $224	Free Cancellation	Rating 7.4 9,105 reviews	Search United Airlines flights
Delta	PriceFrom $232	Free Cancellation	Rating 7.9 8,014 reviews	Search Delta flights
American Airlines	PriceFrom $248	Free Cancellation	Rating 7.2 11,054 reviews	Search American Airlines flights

Pigeon Forge

Gatlinburg

Cherokee

Bryson City

Morristown

Corbin

Maryville

Crossville

Murphy

Alcoa

Oak Ridge

Newport

Lenoir City

Kodak

Dandridge

Jefferson City

Clinton

Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Buffalo to Knoxville for you.

Can I find flights from Buffalo to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Buffalo to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Buffalo to Knoxville?

momondo helps you find the best flight between Buffalo and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Buffalo to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Buffalo to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.