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Cheap flights from Buffalo to Knoxville from $126

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Knoxville departing on 12/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Buffalo to Knoxville

Cheap round-trip flights

Delta Logo
5:55 pm - 9:32 pmBUF-TYS
3h 37m1 stop
Delta Logo
5:30 am - 11:16 amTYS-BUF
5h 46m1 stop
$251Delta
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
5:20 am - 10:52 amBUF-TYS
5h 32m1 stop
American Airlines Logo
5:35 pm - 11:36 pmTYS-BUF
6h 01m1 stop
$260American Airlines
Find Deal
Thu, Nov 13 - Sat, Nov 15
American Airlines Logo
5:20 am - 10:52 amBUF-TYS
5h 32m1 stop
American Airlines Logo
6:30 am - 11:02 amTYS-BUF
4h 32m1 stop
$269American Airlines
Find Deal
Thu, Nov 13 - Sun, Nov 23
American Airlines Logo
11:50 am - 4:03 pmBUF-TYS
4h 13m1 stop
American Airlines Logo
8:37 pm - 12:15 amTYS-BUF
3h 38m1 stop
$279American Airlines
Find Deal
Thu, Oct 2 - Mon, Oct 6
American Airlines Logo
3:04 pm - 9:24 pmBUF-TYS
6h 20m1 stop
American Airlines Logo
6:16 pm - 11:36 pmTYS-BUF
5h 20m1 stop
$285American Airlines
Find Deal
Sat, Nov 8 - Mon, Nov 10
American Airlines Logo
5:33 pm - 11:51 pmBUF-TYS
6h 18m2 stops
American Airlines Logo
6:16 pm - 11:36 pmTYS-BUF
5h 20m1 stop
$299American Airlines
Find Deal
Sat, Nov 8 - Mon, Nov 10
United Airlines Logo
6:00 am - 10:49 amBUF-TYS
4h 49m1 stop
United Airlines Logo
6:45 am - 2:19 pmTYS-BUF
7h 34m2 stops
$305United Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
5:20 am - 10:52 amBUF-TYS
5h 32m1 stop
American Airlines Logo
8:04 pm - 12:08 amTYS-BUF
4h 04m1 stop
$314American Airlines
Find Deal
Thu, Nov 13 - Sun, Nov 16
United Airlines Logo
10:28 am - 2:45 pmBUF-TYS
4h 17m1 stop
United Airlines Logo
7:00 am - 1:22 pmTYS-BUF
6h 22m1 stop
$324United Airlines
Find Deal
Wed, Oct 8 - Wed, Oct 15
Delta Logo
7:30 pm - 11:46 pmBUF-TYS
4h 16m1 stop
Delta Logo
5:44 am - 11:01 amTYS-BUF
5h 17m1 stop
$337Delta
Find Deal
Thu, Oct 16 - Mon, Oct 20

Delta flights from Buffalo to Knoxville

Our best Delta deals on Buffalo to Knoxville flight tickets
Delta
Feb 21
BUF5:55 pmBuffalo
3h 37m
1 stop
TYS9:32 pmKnoxville McGhee Tyson
Feb 25
TYS5:30 amKnoxville McGhee Tyson
5h 46m
1 stop
BUF11:16 amBuffalo
$251
Find similar
Delta
Oct 16
BUF7:30 pmBuffalo
4h 16m
1 stop
TYS11:46 pmKnoxville McGhee Tyson
Oct 20
TYS5:44 amKnoxville McGhee Tyson
5h 17m
1 stop
BUF11:01 amBuffalo
$337
Find similar
Delta
Oct 16
BUF7:30 pmBuffalo
4h 16m
1 stop
TYS11:46 pmKnoxville McGhee Tyson
Oct 20
TYS5:44 amKnoxville McGhee Tyson
5h 17m
1 stop
BUF11:01 amBuffalo
$339
Find similar

American Airlines flights from Buffalo to Knoxville

Our best American Airlines deals on Buffalo to Knoxville flight tickets
American Airlines
Nov 13
BUF5:20 amBuffalo
5h 32m
1 stop
TYS10:52 amKnoxville McGhee Tyson
Nov 15
TYS5:35 pmKnoxville McGhee Tyson
6h 01m
1 stop
BUF11:36 pmBuffalo
$260
Find similar
American Airlines
Nov 13
BUF5:20 amBuffalo
5h 32m
1 stop
TYS10:52 amKnoxville McGhee Tyson
Nov 23
TYS6:30 amKnoxville McGhee Tyson
4h 32m
1 stop
BUF11:02 amBuffalo
$269
Find similar
American Airlines
Oct 2
BUF11:50 amBuffalo
4h 13m
1 stop
TYS4:03 pmKnoxville McGhee Tyson
Oct 6
TYS8:37 pmKnoxville McGhee Tyson
3h 38m
1 stop
BUF12:15 amBuffalo
$279
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 19, 2025.
Use the filters below to find and compare flights from Buffalo to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sat 2/21

5:55 pm-9:32 pm

1 stop3h 37m

Knoxville McGhee Tyson

Wed 2/25

5:30 am-11:16 am

1 stop5h 46m

$251

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 11/13

5:20 am-10:52 am

1 stop5h 32m

Knoxville McGhee Tyson

Sat 11/15

5:35 pm-11:36 pm

1 stop6h 01m

$260

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 11/13

5:20 am-10:52 am

1 stop5h 32m

Knoxville McGhee Tyson

Sun 11/23

6:30 am-11:02 am

1 stop4h 32m

$269

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 10/2

11:50 am-4:03 pm

1 stop4h 13m

Knoxville McGhee Tyson

Mon 10/6

8:37 pm-12:15 am

1 stop3h 38m

$279

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sat 11/8

3:04 pm-9:24 pm

1 stop6h 20m

Knoxville McGhee Tyson

Mon 11/10

6:16 pm-11:36 pm

1 stop5h 20m

$285

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sat 11/8

5:33 pm-11:51 pm

2 stops6h 18m

Knoxville McGhee Tyson

Mon 11/10

6:16 pm-11:36 pm

1 stop5h 20m

$299

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Sat 2/21

6:00 am-10:49 am

1 stop4h 49m

Knoxville McGhee Tyson

Wed 2/25

6:45 am-2:19 pm

2 stops7h 34m

$305

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 11/13

5:20 am-10:52 am

1 stop5h 32m

Knoxville McGhee Tyson

Sun 11/16

8:04 pm-12:08 am

1 stop4h 04m

$314

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Wed 10/8

10:28 am-2:45 pm

1 stop4h 17m

Knoxville McGhee Tyson

Wed 10/15

7:00 am-1:22 pm

1 stop6h 22m

$324

BuffaloKnoxville

BUF - TYS

BUFTYS

Buffalo

Thu 10/16

7:30 pm-11:46 pm

1 stop4h 16m

Knoxville McGhee Tyson

Mon 10/20

5:44 am-11:01 am

1 stop5h 17m

$337

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Buffalo to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of February is, on average, the cheapest month to fly to Knoxville from Buffalo, with most prices found around $278. If you aren’t able to travel during the month of February, then book flights to Knoxville from Buffalo during May instead. Flights to Knoxville in May, while not as cheap as those in February, still average around $303.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Buffalo to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $282. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Buffalo to Knoxville for around $494.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Buffalo to Knoxville when you can find flight prices for as low as $272. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $381.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Buffalo when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $339 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Buffalo for as low as $275 on momondo.

How have Buffalo to Knoxville flight prices changed over time?

When to book flights from Buffalo to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Knoxville (BUF to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Knoxville

Direct flights

None
There are no direct flights from Buffalo to Knoxville. There are no popular flight routes from Buffalo to Knoxville.
Search flight deals

  • How far is Buffalo to Knoxville McGhee Tyson by plane?

    The distance between Buffalo and Knoxville McGhee Tyson is about 548.4 mi. By plane, this route typically takes 3h 37m.

  • When did momondo last update prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Buffalo Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Buffalo Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Buffalo Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Buffalo to Knoxville?

Best airlines flying from Buffalo to Knoxville

Compare and see reviews for airlines that fly from Buffalo to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $224Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights
DeltaPriceFrom $232Free CancellationRating
7.9
7,964 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Buffalo to Knoxville for you.

Can I find flights from Buffalo to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Buffalo to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Buffalo to Knoxville?

momondo helps you find the best flight between Buffalo and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Buffalo to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Buffalo to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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