Latest deals
Insights
When to book
FAQs
Price Alerts

Cheap flights from Tampa to Florence from $382

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Tampa to Florence departing on 3/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Tampa to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
11:41 am - 3:50 pm
TPA
-
FLO
4h 09m
1 stop
American Airlines Logo
5:20 am - 10:49 am
FLO
-
TPA
5h 29m
1 stop
$427American Airlines
Wed, Apr 8 - Sat, Apr 11
American Airlines Logo
8:03 am - 3:50 pm
TPA
-
FLO
7h 47m
2 stops
American Airlines Logo
5:20 am - 10:49 am
FLO
-
TPA
5h 29m
1 stop
$432American Airlines
Wed, Apr 8 - Sat, Apr 11
American Airlines Logo
9:05 am - 3:50 pm
TPA
-
FLO
6h 45m
2 stops
American Airlines Logo
4:16 pm - 11:50 pm
FLO
-
TPA
7h 34m
2 stops
$437American Airlines
Wed, Apr 8 - Sat, Apr 11
American Airlines Logo
10:45 am - 3:50 pm
TPA
-
FLO
5h 05m
1 stop
American Airlines Logo
5:20 am - 10:49 am
FLO
-
TPA
5h 29m
1 stop
$451American Airlines
Thu, Apr 9 - Sat, Apr 11
American Airlines Logo
10:45 am - 3:50 pm
TPA
-
FLO
5h 05m
1 stop
American Airlines Logo
4:16 pm - 11:50 pm
FLO
-
TPA
7h 34m
2 stops
$456American Airlines
Thu, Apr 9 - Sat, Apr 11
American Airlines Logo
4:49 pm - 11:08 pm
TPA
-
FLO
6h 19m
1 stop
American Airlines Logo
5:16 am - 9:53 am
FLO
-
TPA
4h 37m
1 stop
$487American Airlines
Tue, Mar 24 - Sat, Mar 28
American Airlines Logo
8:00 am - 5:21 pm
TPA
-
FLO
9h 21m
2 stops
American Airlines Logo
5:16 am - 9:53 am
FLO
-
TPA
4h 37m
1 stop
$492American Airlines
Tue, Mar 24 - Sat, Mar 28
American Airlines Logo
8:20 am - 2:11 pm
TPA
-
FLO
5h 51m
1 stop
American Airlines Logo
11:15 am - 4:52 pm
FLO
-
TPA
5h 37m
1 stop
$507American Airlines
Sat, Aug 1 - Sat, Aug 8
American Airlines Logo
6:00 am - 2:11 pm
TPA
-
FLO
8h 11m
2 stops
American Airlines Logo
11:15 am - 2:42 pm
FLO
-
TPA
3h 27m
1 stop
$512American Airlines
Sat, Aug 1 - Sat, Aug 8
American Airlines Logo
6:00 am - 2:11 pm
TPA
-
FLO
8h 11m
2 stops
American Airlines Logo
2:34 pm - 11:59 pm
FLO
-
TPA
9h 25m
2 stops
$517American Airlines
Sat, Aug 1 - Sat, Aug 8

American Airlines flights from Tampa to Florence, South Carolina

Our best American Airlines deals on Tampa to Florence, South Carolina flight tickets
American Airlines
Apr 8
TPA11:41 amTampa
4h 09m
1 stop
FLO3:50 pmFlorence
Apr 11
FLO5:20 amFlorence
5h 29m
1 stop
TPA10:49 amTampa
$427
American Airlines
Apr 8
TPA8:03 amTampa
7h 47m
2 stops
FLO3:50 pmFlorence
Apr 11
FLO5:20 amFlorence
5h 29m
1 stop
TPA10:49 amTampa
$432
American Airlines
Apr 8
TPA9:05 amTampa
6h 45m
2 stops
FLO3:50 pmFlorence
Apr 11
FLO4:16 pmFlorence
7h 34m
2 stops
TPA11:50 pmTampa
$437

momondo Fare Finder

 
Customize your flight search to find flights from Tampa to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 9, 2026.
Use the filters below to find and compare flights from Tampa to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Wed 4/8

11:41 am-3:50 pm

1 stop4h 09m

Florence

Sat 4/11

5:20 am-10:49 am

1 stop5h 29m

$427

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Wed 4/8

8:03 am-3:50 pm

2 stops7h 47m

Florence

Sat 4/11

5:20 am-10:49 am

1 stop5h 29m

$432

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Wed 4/8

9:05 am-3:50 pm

2 stops6h 45m

Florence

Sat 4/11

4:16 pm-11:50 pm

2 stops7h 34m

$437

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Thu 4/9

10:45 am-3:50 pm

1 stop5h 05m

Florence

Sat 4/11

5:20 am-10:49 am

1 stop5h 29m

$451

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Thu 4/9

10:45 am-3:50 pm

1 stop5h 05m

Florence

Sat 4/11

4:16 pm-11:50 pm

2 stops7h 34m

$456

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Tue 3/24

4:49 pm-11:08 pm

1 stop6h 19m

Florence

Sat 3/28

5:16 am-9:53 am

1 stop4h 37m

$487

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Tue 3/24

8:00 am-5:21 pm

2 stops9h 21m

Florence

Sat 3/28

5:16 am-9:53 am

1 stop4h 37m

$492

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 8/1

8:20 am-2:11 pm

1 stop5h 51m

Florence

Sat 8/8

11:15 am-4:52 pm

1 stop5h 37m

$507

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 8/1

6:00 am-2:11 pm

2 stops8h 11m

Florence

Sat 8/8

11:15 am-2:42 pm

1 stop3h 27m

$512

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 8/1

6:00 am-2:11 pm

2 stops8h 11m

Florence

Sat 8/8

2:34 pm-11:59 pm

2 stops9h 25m

$517

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
1
2

See travel insights to Florence from

How to get the cheapest flight ticket from Tampa to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Tampa to Florence?

American Airlines is the most popular carrier operating from Tampa to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Frontier and Breeze Airways are the top three most popular airlines that fly to Florence, South Carolina from Tampa according to our data. American Airlines is the first choice among our users, with 31% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 7 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Tampa to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Tampa to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Tampa to Florence, South Carolina (TPA to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Tampa to Florence, South Carolina

Fastest flight time

5h 05m

Direct flights

None
The fastest flight from Tampa to Florence, South Carolina takes 5h 05m
There are no direct flights from Tampa to Florence, South Carolina. There are no popular flight routes from Tampa to Florence, South Carolina.
Search flight deals

  • How far is Tampa to Florence by plane?

    Tampa and Florence are 459.5 mi apart from one another. Typically, this will take 5h 05m by plane in normal conditions.

  • When did momondo last update prices for flights from Tampa Airport to Florence Airport?

    Prices for flights from Tampa Airport to Florence Airport were last updated today.

  • How old do you have to be to fly from Tampa Airport to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Tampa Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The required travel and health documents for your Florence Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Tampa to Florence?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Tampa to Florence. momondo saves you time and could save you money on your trip.

Can I find flights from Tampa to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Tampa with this policy.

How can momondo help me find flights from Tampa to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Tampa to Florence.

I’m not ready to book a flight from Tampa to Florence right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Florence, momondo offers a useful price alert feature which will track prices for flights to Florence from Tampa and alert you when they change.

An easier way to manage your Florence, South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 4/8
Wed 4/15
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States