What is the cheapest airline that flies from Tampa to Florence?

American Airlines is the most popular carrier operating from Tampa to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Spirit Airlines and Frontier are the top three most popular airlines that fly to Florence, South Carolina from Tampa according to our data. American Airlines is the first choice among our users, with 35% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 6 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Tampa Airport to Florence Airport?

Prices for flights from Tampa Airport to Florence Airport were last updated today.

How many operators does momondo search for flights from Tampa Airport to Florence Airport?

As of August 2025, there is 1 operator available to choose from for flights from Tampa Airport to Florence Airport.

How old do you have to be to fly from Tampa Airport to Florence Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Tampa Airport to Florence Airport.

What documentation or ID do you need to fly to Florence Airport?

The required travel and health documents for your Florence Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$278 Cheap Flights from Tampa to Florence in 2025

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Find the cheapest flights from Tampa to Florence

Round-trip

One-way

Cheap round-trip flights

11:43 am - 11:13 pmTPA-FLO

11h 30m2 stops

6:14 am - 6:04 pmFLO-TPA

11h 50m2 stops

$378American Airlines

Find Deal

mar., oct. 7 - mar., oct. 14

7:03 pm - 11:13 pmTPA-FLO

4h 10m1 stop

6:14 am - 12:14 pmFLO-TPA

6h 00m1 stop

$387American Airlines

Find Deal

mar., oct. 7 - mar., oct. 14

6:00 am - 2:54 pmTPA-FLO

8h 54m2 stops

6:14 am - 10:18 amFLO-TPA

4h 04m1 stop

$392American Airlines

Find Deal

mar., oct. 7 - mar., oct. 14

9:50 am - 3:04 pmTPA-FLO

5h 14m1 stop

9:05 am - 2:42 pmFLO-TPA

5h 37m1 stop

$472American Airlines

Find Deal

mié., ago. 27 - dom., ago. 31

9:50 am - 3:04 pmTPA-FLO

5h 14m1 stop

9:05 am - 6:50 pmFLO-TPA

9h 45m2 stops

$477American Airlines

Find Deal

mié., ago. 27 - dom., ago. 31

6:00 am - 3:04 pmTPA-FLO

9h 04m2 stops

11:15 am - 6:50 pmFLO-TPA

7h 35m2 stops

$482American Airlines

Find Deal

mié., ago. 27 - dom., ago. 31

American Airlines flights from Tampa to Florence, South Carolina

Our best American Airlines deals on Tampa to Florence, South Carolina flight tickets

American Airlines

Oct 7

TPA11:43 amTampa

11h 30m

2 stops

FLO11:13 pmFlorence

Oct 14

FLO6:14 amFlorence

11h 50m

2 stops

TPA6:04 pmTampa

$378

Find similar

American Airlines

Oct 7

TPA7:03 pmTampa

4h 10m

1 stop

FLO11:13 pmFlorence

Oct 14

FLO6:14 amFlorence

6h 00m

1 stop

TPA12:14 pmTampa

$387

Find similar

American Airlines

Oct 7

TPA6:00 amTampa

8h 54m

2 stops

FLO2:54 pmFlorence

Oct 14

FLO6:14 amFlorence

4h 04m

1 stop

TPA10:18 amTampa

$392

Find similar

momondo Fare Finder

Use the filters below to find and compare flights from Tampa to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

TampaFlorence

TPA - FLO

TPAFLO

Tampa

mar. 10/7

11:43 am-11:13 pm

2 stops11h 30m

Florence

mar. 10/14

6:14 am-6:04 pm

2 stops11h 50m

$378

TampaFlorence

TPA - FLO

TPAFLO

Tampa

mar. 10/7

7:03 pm-11:13 pm

1 stop4h 10m

Florence

mar. 10/14

6:14 am-12:14 pm

1 stop6h 00m

$387

TampaFlorence

TPA - FLO

TPAFLO

Tampa

mar. 10/7

6:00 am-2:54 pm

2 stops8h 54m

Florence

mar. 10/14

6:14 am-10:18 am

1 stop4h 04m

$392

TampaFlorence

TPA - FLO

TPAFLO

Tampa

mié. 8/27

9:50 am-3:04 pm

1 stop5h 14m

Florence

dom. 8/31

9:05 am-2:42 pm

1 stop5h 37m

$472

TampaFlorence

TPA - FLO

TPAFLO

Tampa

mié. 8/27

9:50 am-3:04 pm

1 stop5h 14m

Florence

dom. 8/31

9:05 am-6:50 pm

2 stops9h 45m

$477

TampaFlorence

TPA - FLO

TPAFLO

Tampa

mié. 8/27

6:00 am-3:04 pm

2 stops9h 04m

Florence

dom. 8/31

11:15 am-6:50 pm

2 stops7h 35m

$482

TampaFlorence

TPA - FLO

TPAFLO

Tampa

jue. 8/28

6:10 am-10:50 am

1 stop4h 40m

$367

TampaFlorence

TPA - FLO

TPAFLO

Tampa

jue. 8/28

3:37 pm-11:59 pm

2 stops8h 22m

$372

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Tampa to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest day to depart on your flight to Florence, South Carolina?

On average, the least expensive day to fly to Florence, South Carolina from Tampa is on a Tuesday. momondo users have found tickets for Tuesday departures for as low as $341. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Thursday is the most expensive day to depart from Tampa because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $646.

What is the cheapest time of day to depart on your flight to Florence, South Carolina?

According to our data, the cheapest time of day to fly to Florence, South Carolina is in the morning. momondo users have found flights departing from Tampa to Florence, South Carolina in the morning for as low as $366. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In the afternoon is when there is more demand to fly to Florence, South Carolina, so prices are often more expensive at around $593 per ticket.

When to book flights from Tampa to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Tampa to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Tampa to Florence, South Carolina (TPA to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Tampa to Florence, South Carolina

Best Price Found	$367
Fastest flight time	4h 10m
Direct flights	None
Airports in Florence, South Carolina	1 airport

The best one-way flight to Florence, South Carolina from Tampa in the past 72 hours is $367. The best round-trip flight deal from Tampa to Florence, South Carolina found on momondo in the last 72 hours is $378.

The fastest flight from Tampa to Florence, South Carolina takes 4h 10m

There are no direct flights from Tampa to Florence, South Carolina. Popular non-direct route for this connection is Tampa Airport - Florence Airport.

There is 1 airport near Florence, South Carolina: Florence (FLO)

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How far is Tampa to Florence by plane?
Tampa and Florence are 459.5 mi apart from one another. Typically, this will take 4h 10m by plane in normal conditions.
When did momondo last update prices for flights from Tampa Airport to Florence Airport?
Prices for flights from Tampa Airport to Florence Airport were last updated today.
How many operators does momondo search for flights from Tampa Airport to Florence Airport?
As of August 2025, there is 1 operator available to choose from for flights from Tampa Airport to Florence Airport.
How old do you have to be to fly from Tampa Airport to Florence Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Tampa Airport to Florence Airport.
What documentation or ID do you need to fly to Florence Airport?
The required travel and health documents for your Florence Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from Tampa to Florence, South Carolina?
momondo data reveals that the most frequently booked airline on the route from Tampa to Florence, South Carolina is American Airlines, representing 100% of all bookings.

Best airlines flying from Tampa to Florence, South Carolina

Compare and see reviews for airlines that fly from Tampa to Florence, South Carolina with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $315	Free Cancellation	Rating 7.2 10,000 reviews		Search American Airlines flights

Sumter

Lake City

Hartsville

Bennettsville

Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Tampa to Florence?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Tampa to Florence. momondo saves you time and could save you money on your trip.

Can I find flights from Tampa to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Tampa with this policy.

How can momondo help me find flights from Tampa to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Tampa to Florence.

I’m not ready to book a flight from Tampa to Florence right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Florence, momondo offers a useful price alert feature which will track prices for flights to Florence from Tampa and alert you when they change.