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Cheap flights from Tampa to Florence from $427

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Tampa to Florence departing on 8/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Tampa to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
9:30 am - 2:56 pm
TPA
-
FLO
5h 26m
1 stop
American Airlines Logo
6:22 am - 10:32 am
FLO
-
TPA
4h 10m
1 stop
$511American Airlines
Sat, Aug 15 - Fri, Aug 21
American Airlines Logo
10:36 am - 2:09 pm
TPA
-
FLO
3h 33m
1 stop
American Airlines Logo
2:34 pm - 8:27 pm
FLO
-
TPA
5h 53m
1 stop
$515American Airlines
Thu, Oct 15 - Thu, Oct 22
American Airlines Logo
7:15 am - 2:10 pm
TPA
-
FLO
6h 55m
1 stop
American Airlines Logo
3:22 pm - 9:21 pm
FLO
-
TPA
5h 59m
1 stop
$552American Airlines
Sun, Aug 2 - Wed, Aug 12
American Airlines Logo
8:38 am - 2:10 pm
TPA
-
FLO
5h 32m
1 stop
American Airlines Logo
6:22 am - 10:32 am
FLO
-
TPA
4h 10m
1 stop
$597American Airlines
Sat, Aug 1 - Wed, Aug 12
American Airlines Logo
6:00 am - 2:10 pm
TPA
-
FLO
8h 10m
2 stops
American Airlines Logo
6:22 am - 10:32 am
FLO
-
TPA
4h 10m
1 stop
$642American Airlines
Sat, Aug 1 - Wed, Aug 12
American Airlines Logo
7:00 am - 2:56 pm
TPA
-
FLO
7h 56m
2 stops
American Airlines Logo
6:22 am - 10:32 am
FLO
-
TPA
4h 10m
1 stop
$646American Airlines
Sat, Aug 15 - Fri, Aug 21
American Airlines Logo
10:12 am - 2:10 pm
TPA
-
FLO
3h 58m
1 stop
American Airlines Logo
6:22 am - 6:20 pm
FLO
-
TPA
11h 58m
2 stops
$687American Airlines
Sun, Aug 2 - Wed, Aug 12
American Airlines Logo
10:36 am - 2:09 pm
TPA
-
FLO
3h 33m
1 stop
American Airlines Logo
2:34 pm - 10:59 pm
FLO
-
TPA
8h 25m
2 stops
$719American Airlines
Thu, Oct 15 - Thu, Oct 22
American Airlines Logo
6:00 am - 2:10 pm
TPA
-
FLO
8h 10m
2 stops
American Airlines Logo
6:22 am - 1:12 pm
FLO
-
TPA
6h 50m
2 stops
$760American Airlines
Fri, Jul 31 - Wed, Aug 12
American Airlines Logo
6:00 am - 2:10 pm
TPA
-
FLO
8h 10m
2 stops
American Airlines Logo
3:22 pm - 11:59 pm
FLO
-
TPA
8h 37m
2 stops
$761American Airlines
Sun, Aug 2 - Tue, Aug 11

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American Airlines flights from Tampa to Florence, South Carolina

Our best American Airlines deals on Tampa to Florence, South Carolina flight tickets
American Airlines
Aug 15
TPA9:30 amTampa
5h 26m
1 stop
FLO2:56 pmFlorence
Aug 21
FLO6:22 amFlorence
4h 10m
1 stop
TPA10:32 amTampa
$511
American Airlines
Oct 15
TPA10:36 amTampa
3h 33m
1 stop
FLO2:09 pmFlorence
Oct 22
FLO2:34 pmFlorence
5h 53m
1 stop
TPA8:27 pmTampa
$515
American Airlines
Aug 2
TPA7:15 amTampa
6h 55m
1 stop
FLO2:10 pmFlorence
Aug 12
FLO3:22 pmFlorence
5h 59m
1 stop
TPA9:21 pmTampa
$552

momondo Fare Finder

 
Customize your flight search to find flights from Tampa to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 21, 2026.
Use the filters below to find and compare flights from Tampa to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 8/15

9:30 am-2:56 pm

1 stop5h 26m

Florence

Fri 8/21

6:22 am-10:32 am

1 stop4h 10m

$511
Quickest round-trip

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Thu 10/15

10:36 am-2:09 pm

1 stop3h 33m

Florence

Thu 10/22

2:34 pm-8:27 pm

1 stop5h 53m

$515

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sun 8/2

7:15 am-2:10 pm

1 stop6h 55m

Florence

Wed 8/12

3:22 pm-9:21 pm

1 stop5h 59m

$552

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 8/1

8:38 am-2:10 pm

1 stop5h 32m

Florence

Wed 8/12

6:22 am-10:32 am

1 stop4h 10m

$597

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 8/1

6:00 am-2:10 pm

2 stops8h 10m

Florence

Wed 8/12

6:22 am-10:32 am

1 stop4h 10m

$642

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 8/15

7:00 am-2:56 pm

2 stops7h 56m

Florence

Fri 8/21

6:22 am-10:32 am

1 stop4h 10m

$646

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sun 8/2

10:12 am-2:10 pm

1 stop3h 58m

Florence

Wed 8/12

6:22 am-6:20 pm

2 stops11h 58m

$687

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Thu 10/15

10:36 am-2:09 pm

1 stop3h 33m

Florence

Thu 10/22

2:34 pm-10:59 pm

2 stops8h 25m

$719

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Fri 7/31

6:00 am-2:10 pm

2 stops8h 10m

Florence

Wed 8/12

6:22 am-1:12 pm

2 stops6h 50m

$760

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sun 8/2

6:00 am-2:10 pm

2 stops8h 10m

Florence

Tue 8/11

3:22 pm-11:59 pm

2 stops8h 37m

$761

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Tampa to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Tampa to Florence?

American Airlines is the most popular carrier operating from Tampa to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Breeze Airways and Frontier are the top three most popular airlines that fly to Florence, South Carolina from Tampa according to our data. American Airlines is the first choice among our users, with 33% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 5 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Tampa to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Tampa to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Tampa to Florence, South Carolina (TPA to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Tampa to Florence, South Carolina

Fastest flight time

3h 33m

Direct flights

None
The fastest flight from Tampa to Florence, South Carolina takes 3h 33m
There are no direct flights from Tampa to Florence, South Carolina. There are no popular flight routes from Tampa to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Tampa to Florence, South Carolina

  • How far is Tampa to Florence by plane?

    Tampa and Florence are 459.5 mi apart from one another. Typically, this will take 3h 33m by plane in normal conditions.

  • When did momondo last update prices for flights from Tampa Airport to Florence Airport?

    Prices for flights from Tampa Airport to Florence Airport were last updated today.

  • How old do you have to be to fly from Tampa Airport to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Tampa Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The required travel and health documents for your Florence Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Tampa to Florence?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Tampa to Florence. momondo saves you time and could save you money on your trip.

Can I find flights from Tampa to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Tampa with this policy.

How can momondo help me find flights from Tampa to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Tampa to Florence.

I’m not ready to book a flight from Tampa to Florence right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Florence, momondo offers a useful price alert feature which will track prices for flights to Florence from Tampa and alert you when they change.

An easier way to manage your Florence, South Carolina trip

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