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Cheap flights from Syracuse to Florence from $393

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Florence departing on 12/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

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American Airlines Logo
6:03 am - 10:45 amSYR-FLO
4h 42m1 stop
American Airlines Logo
5:35 pm - 11:50 pmFLO-SYR
6h 15m1 stop
$431American Airlines
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Tue, Nov 25 - Tue, Dec 2
American Airlines Logo
6:03 am - 10:45 amSYR-FLO
4h 42m1 stop
American Airlines Logo
10:29 am - 5:01 pmFLO-SYR
6h 32m2 stops
$436American Airlines
Find Deal
Tue, Nov 25 - Tue, Dec 2
American Airlines Logo
6:12 am - 10:24 amSYR-FLO
4h 12m1 stop
American Airlines Logo
5:13 am - 10:45 amFLO-SYR
5h 32m1 stop
$503American Airlines
Find Deal
Wed, Mar 25 - Sat, Mar 28
American Airlines Logo
7:48 pm - 11:38 pmSYR-FLO
3h 50m1 stop
American Airlines Logo
5:13 am - 11:48 amFLO-SYR
6h 35m2 stops
$508American Airlines
Find Deal
Wed, Mar 25 - Sat, Mar 28
American Airlines Logo
5:28 am - 2:05 pmSYR-FLO
8h 37m2 stops
American Airlines Logo
11:09 am - 10:17 pmFLO-SYR
11h 08m2 stops
$513American Airlines
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Wed, Mar 25 - Sat, Mar 28
American Airlines Logo
12:20 pm - 11:41 pmSYR-FLO
11h 21m2 stops
American Airlines Logo
10:29 am - 5:01 pmFLO-SYR
6h 32m2 stops
$637American Airlines
Find Deal
Tue, Nov 25 - Tue, Dec 2

American Airlines flights from Syracuse to Florence, South Carolina

Our best American Airlines deals on Syracuse to Florence, South Carolina flight tickets
American Airlines
Nov 25
SYR6:03 amSyracuse Hancock Intl
4h 42m
1 stop
FLO10:45 amFlorence
Dec 2
FLO5:35 pmFlorence
6h 15m
1 stop
SYR11:50 pmSyracuse Hancock Intl
$431
Find similar
American Airlines
Nov 25
SYR6:03 amSyracuse Hancock Intl
4h 42m
1 stop
FLO10:45 amFlorence
Dec 2
FLO10:29 amFlorence
6h 32m
2 stops
SYR5:01 pmSyracuse Hancock Intl
$436
Find similar
American Airlines
Mar 25
SYR6:12 amSyracuse Hancock Intl
4h 12m
1 stop
FLO10:24 amFlorence
Mar 28
FLO5:13 amFlorence
5h 32m
1 stop
SYR10:45 amSyracuse Hancock Intl
$503
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Syracuse to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Tue 11/25

6:03 am-10:45 am

1 stop4h 42m

Florence

Tue 12/2

5:35 pm-11:50 pm

1 stop6h 15m

$431

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Tue 11/25

6:03 am-10:45 am

1 stop4h 42m

Florence

Tue 12/2

10:29 am-5:01 pm

2 stops6h 32m

$436

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Wed 3/25

6:12 am-10:24 am

1 stop4h 12m

Florence

Sat 3/28

5:13 am-10:45 am

1 stop5h 32m

$503

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Wed 3/25

7:48 pm-11:38 pm

1 stop3h 50m

Florence

Sat 3/28

5:13 am-11:48 am

2 stops6h 35m

$508

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Wed 3/25

5:28 am-2:05 pm

2 stops8h 37m

Florence

Sat 3/28

11:09 am-10:17 pm

2 stops11h 08m

$513

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Tue 11/25

12:20 pm-11:41 pm

2 stops11h 21m

Florence

Tue 12/2

10:29 am-5:01 pm

2 stops6h 32m

$637

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Fri 12/19

7:05 am-12:26 pm

1 stop5h 21m

$393

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Fri 12/19

3:22 pm-12:15 am

2 stops8h 53m

$398

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Sun 11/30

5:30 pm-11:41 pm

1 stop6h 11m

$493

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Sun 11/30

3:14 pm-11:41 pm

2 stops8h 27m

$716

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Syracuse to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Syracuse Hancock Intl to Florence?

American Airlines is the most popular carrier operating from Syracuse Hancock Intl to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Breeze Airways and Delta are the top three most popular airlines that fly to Florence, South Carolina from Syracuse according to our data. American Airlines is the first choice among our users, with 60% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 9 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Syracuse to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to Florence, South Carolina (SYR to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Florence, South Carolina

Direct flights

None
There are no direct flights from Syracuse to Florence, South Carolina. There are no popular flight routes from Syracuse to Florence, South Carolina.
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  • How far is Syracuse Hancock Intl to Florence by plane?

    The straight-line distance from Syracuse Hancock Intl to Florence is 641.4 mi. In terms of flight time, this usually takes a little over 3h 50m.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Florence Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Florence Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Florence Airport?

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Syracuse Hancock Intl Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Syracuse to Florence, South Carolina?

Best airlines flying from Syracuse to Florence, South Carolina

Compare and see reviews for airlines that fly from Syracuse to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $379Free CancellationRating
7.2
11,034 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Syracuse to Florence for you.

Can I find flights from Syracuse to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Syracuse which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Syracuse to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Syracuse to Florence.

I’m not ready to book a flight from Syracuse to Florence right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florence from Syracuse. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Florence, South Carolina trip

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