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Cheap flights from Syracuse to Florence from $413

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Florence departing on 6/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Syracuse to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
10:36 am - 11:37 pm
SYR
-
FLO
13h 01m
2 stops
American Airlines Logo
2:35 pm - 6:36 pm
FLO
-
SYR
4h 01m
1 stop
$548American Airlines
Fri, Jul 31 - Sun, Aug 2
American Airlines Logo
7:34 pm - 11:37 pm
SYR
-
FLO
4h 03m
1 stop
American Airlines Logo
2:35 pm - 6:36 pm
FLO
-
SYR
4h 01m
1 stop
$561American Airlines
Sun, Jul 12 - Sun, Jul 19
American Airlines Logo
8:00 am - 2:10 pm
SYR
-
FLO
6h 10m
1 stop
American Airlines Logo
2:35 pm - 6:44 pm
FLO
-
SYR
4h 09m
1 stop
$581American Airlines
Tue, Jul 7 - Tue, Jul 14
American Airlines Logo
5:17 pm - 10:59 pm
SYR
-
FLO
5h 42m
1 stop
American Airlines Logo
3:22 pm - 9:54 pm
FLO
-
SYR
6h 32m
1 stop
$599American Airlines
Wed, Aug 5 - Sat, Aug 15
American Airlines Logo
7:34 pm - 11:37 pm
SYR
-
FLO
4h 03m
1 stop
American Airlines Logo
5:17 am - 11:16 am
FLO
-
SYR
5h 59m
1 stop
$606American Airlines
Thu, Jul 9 - Tue, Jul 14
American Airlines Logo
7:34 pm - 11:37 pm
SYR
-
FLO
4h 03m
1 stop
American Airlines Logo
5:17 am - 10:06 am
FLO
-
SYR
28h 49m
2 stops
$612American Airlines
Tue, Jul 7 - Wed, Jul 15
American Airlines Logo
10:36 am - 2:10 pm
SYR
-
FLO
27h 34m
2 stops
American Airlines Logo
2:35 pm - 6:44 pm
FLO
-
SYR
4h 09m
1 stop
$619American Airlines
Fri, Jul 10 - Tue, Jul 14
American Airlines Logo
5:17 pm - 10:59 pm
SYR
-
FLO
5h 42m
1 stop
American Airlines Logo
3:22 pm - 9:54 pm
FLO
-
SYR
6h 32m
1 stop
$624American Airlines
Wed, Aug 5 - Thu, Aug 13
American Airlines Logo
8:28 pm - 2:10 pm
SYR
-
FLO
17h 42m
2 stops
American Airlines Logo
5:17 am - 12:20 am
FLO
-
SYR
19h 03m
2 stops
$627American Airlines
Tue, Jul 7 - Wed, Jul 15
American Airlines Logo
7:34 pm - 11:37 pm
SYR
-
FLO
4h 03m
1 stop
American Airlines Logo
2:35 pm - 10:06 am
FLO
-
SYR
19h 31m
2 stops
$637American Airlines
Thu, Jul 9 - Tue, Jul 14

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American Airlines flights from Syracuse to Florence, South Carolina

Our best American Airlines deals on Syracuse to Florence, South Carolina flight tickets
American Airlines
Jul 31
SYR10:36 amSyracuse Hancock Intl
13h 01m
2 stops
FLO11:37 pmFlorence
Aug 2
FLO2:35 pmFlorence
4h 01m
1 stop
SYR6:36 pmSyracuse Hancock Intl
$548
American Airlines
Jul 12
SYR7:34 pmSyracuse Hancock Intl
4h 03m
1 stop
FLO11:37 pmFlorence
Jul 19
FLO2:35 pmFlorence
4h 01m
1 stop
SYR6:36 pmSyracuse Hancock Intl
$561
American Airlines
Jul 7
SYR8:00 amSyracuse Hancock Intl
6h 10m
1 stop
FLO2:10 pmFlorence
Jul 14
FLO2:35 pmFlorence
4h 09m
1 stop
SYR6:44 pmSyracuse Hancock Intl
$581

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from Syracuse to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Fri 7/31

10:36 am-11:37 pm

2 stops13h 01m

Florence

Sun 8/2

2:35 pm-6:36 pm

1 stop4h 01m

$548
Quickest round-trip

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Sun 7/12

7:34 pm-11:37 pm

1 stop4h 03m

Florence

Sun 7/19

2:35 pm-6:36 pm

1 stop4h 01m

$561

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Tue 7/7

8:00 am-2:10 pm

1 stop6h 10m

Florence

Tue 7/14

2:35 pm-6:44 pm

1 stop4h 09m

$581

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Wed 8/5

5:17 pm-10:59 pm

1 stop5h 42m

Florence

Sat 8/15

3:22 pm-9:54 pm

1 stop6h 32m

$599

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Thu 7/9

7:34 pm-11:37 pm

1 stop4h 03m

Florence

Tue 7/14

5:17 am-11:16 am

1 stop5h 59m

$606

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Tue 7/7

7:34 pm-11:37 pm

1 stop4h 03m

Florence

Wed 7/15

5:17 am-10:06 am

2 stops28h 49m

$612

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Fri 7/10

10:36 am-2:10 pm

2 stops27h 34m

Florence

Tue 7/14

2:35 pm-6:44 pm

1 stop4h 09m

$619

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Wed 8/5

5:17 pm-10:59 pm

1 stop5h 42m

Florence

Thu 8/13

3:22 pm-9:54 pm

1 stop6h 32m

$624

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Tue 7/7

8:28 pm-2:10 pm

2 stops17h 42m

Florence

Wed 7/15

5:17 am-12:20 am

2 stops19h 03m

$627

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Thu 7/9

7:34 pm-11:37 pm

1 stop4h 03m

Florence

Tue 7/14

2:35 pm-10:06 am

2 stops19h 31m

$637

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Syracuse to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Syracuse Hancock Intl to Florence?

American Airlines is the most popular carrier operating from Syracuse Hancock Intl to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Breeze Airways and Delta are the top three most popular airlines that fly to Florence, South Carolina from Syracuse according to our data. American Airlines is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 7 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Syracuse to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to Florence, South Carolina (SYR to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Florence, South Carolina

Fastest flight time

4h 03m

Direct flights

None
The fastest flight from Syracuse to Florence, South Carolina takes 4h 03m
There are no direct flights from Syracuse to Florence, South Carolina. There are no popular flight routes from Syracuse to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Syracuse to Florence, South Carolina

  • How far is Syracuse Hancock Intl to Florence by plane?

    The straight-line distance from Syracuse Hancock Intl to Florence is 641.4 mi. In terms of flight time, this usually takes a little over 4h 03m.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Florence Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Florence Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Florence Airport?

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Syracuse Hancock Intl Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Syracuse to Florence, South Carolina?

Best airlines flying from Syracuse to Florence, South Carolina

Compare and see reviews for airlines that fly from Syracuse to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $412Free CancellationRating
7.1
11,660 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Syracuse to Florence for you.

Can I find flights from Syracuse to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Syracuse which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Syracuse to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Syracuse to Florence.

I’m not ready to book a flight from Syracuse to Florence right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florence from Syracuse. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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