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Cheap flights from Syracuse to Florence from $468

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Florence departing on 3/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Syracuse to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:24 pm - 11:57 pm
SYR
-
FLO
6h 33m
2 stops
American Airlines Logo
5:16 am - 3:35 pm
FLO
-
SYR
10h 19m
2 stops
$468American Airlines
Sa, Mrz 7 - Mi, Mrz 11
American Airlines Logo
5:24 pm - 11:57 pm
SYR
-
FLO
6h 33m
2 stops
American Airlines Logo
6:20 pm - 12:37 am
FLO
-
SYR
6h 17m
1 stop
$494American Airlines
Sa, Mrz 7 - Mi, Mrz 11
American Airlines Logo
6:15 pm - 11:52 pm
SYR
-
FLO
5h 37m
1 stop
American Airlines Logo
5:20 am - 3:45 pm
FLO
-
SYR
10h 25m
2 stops
$521American Airlines
Mi, Apr 29 - So, Mai 3
American Airlines Logo
6:10 am - 3:50 pm
SYR
-
FLO
9h 40m
2 stops
American Airlines Logo
5:20 am - 3:45 pm
FLO
-
SYR
10h 25m
2 stops
$526American Airlines
Mi, Apr 29 - So, Mai 3
American Airlines Logo
6:15 pm - 11:52 pm
SYR
-
FLO
5h 37m
1 stop
American Airlines Logo
5:20 am - 3:45 pm
FLO
-
SYR
10h 25m
2 stops
$554American Airlines
Do, Apr 30 - So, Mai 3
American Airlines Logo
6:15 pm - 11:52 pm
SYR
-
FLO
5h 37m
1 stop
American Airlines Logo
4:16 pm - 11:08 pm
FLO
-
SYR
6h 52m
1 stop
$556American Airlines
Mi, Apr 22 - So, Apr 26
American Airlines Logo
5:22 pm - 11:52 pm
SYR
-
FLO
6h 30m
2 stops
American Airlines Logo
5:20 am - 3:45 pm
FLO
-
SYR
10h 25m
2 stops
$559American Airlines
Do, Apr 30 - So, Mai 3
American Airlines Logo
5:30 am - 3:50 pm
SYR
-
FLO
10h 20m
2 stops
American Airlines Logo
4:16 pm - 11:08 pm
FLO
-
SYR
6h 52m
1 stop
$561American Airlines
Mi, Apr 22 - So, Apr 26
American Airlines Logo
5:30 am - 3:50 pm
SYR
-
FLO
10h 20m
2 stops
American Airlines Logo
4:16 pm - 11:10 pm
FLO
-
SYR
6h 54m
2 stops
$566American Airlines
Mi, Apr 22 - So, Apr 26
American Airlines Logo
6:11 pm - 11:57 pm
SYR
-
FLO
5h 46m
1 stop
American Airlines Logo
6:20 pm - 12:37 am
FLO
-
SYR
6h 17m
1 stop
$589American Airlines
Do, Mrz 5 - Mo, Mrz 9

American Airlines flights from Syracuse to Florence, South Carolina

Our best American Airlines deals on Syracuse to Florence, South Carolina flight tickets
American Airlines
Mar 7
SYR5:24 pmSyracuse Hancock Intl
6h 33m
2 stops
FLO11:57 pmFlorence
Mar 11
FLO5:16 amFlorence
10h 19m
2 stops
SYR3:35 pmSyracuse Hancock Intl
$468
American Airlines
Feb 28
SYR1:52 pmSyracuse Hancock Intl
3h 58m
1 stop
FLO5:50 pmFlorence
Mar 3
FLO5:58 pmFlorence
4h 45m
1 stop
SYR10:43 pmSyracuse Hancock Intl
$489
American Airlines
Mar 7
SYR5:24 pmSyracuse Hancock Intl
6h 33m
2 stops
FLO11:57 pmFlorence
Mar 11
FLO6:20 pmFlorence
6h 17m
1 stop
SYR12:37 amSyracuse Hancock Intl
$494

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated Februar 21, 2026.
Use the filters below to find and compare flights from Syracuse to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Sa 3/7

5:24 pm-11:57 pm

2 stops6h 33m

Florence

Mi 3/11

5:16 am-3:35 pm

2 stops10h 19m

$468

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Sa 3/7

5:24 pm-11:57 pm

2 stops6h 33m

Florence

Mi 3/11

6:20 pm-12:37 am

1 stop6h 17m

$494

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Mi 4/29

6:15 pm-11:52 pm

1 stop5h 37m

Florence

So 5/3

5:20 am-3:45 pm

2 stops10h 25m

$521

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Mi 4/29

6:10 am-3:50 pm

2 stops9h 40m

Florence

So 5/3

5:20 am-3:45 pm

2 stops10h 25m

$526

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Do 4/30

6:15 pm-11:52 pm

1 stop5h 37m

Florence

So 5/3

5:20 am-3:45 pm

2 stops10h 25m

$554

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Mi 4/22

6:15 pm-11:52 pm

1 stop5h 37m

Florence

So 4/26

4:16 pm-11:08 pm

1 stop6h 52m

$556

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Do 4/30

5:22 pm-11:52 pm

2 stops6h 30m

Florence

So 5/3

5:20 am-3:45 pm

2 stops10h 25m

$559

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Mi 4/22

5:30 am-3:50 pm

2 stops10h 20m

Florence

So 4/26

4:16 pm-11:08 pm

1 stop6h 52m

$561

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Mi 4/22

5:30 am-3:50 pm

2 stops10h 20m

Florence

So 4/26

4:16 pm-11:10 pm

2 stops6h 54m

$566

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Do 3/5

6:11 pm-11:57 pm

1 stop5h 46m

Florence

Mo 3/9

6:20 pm-12:37 am

1 stop6h 17m

$589

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Syracuse to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, Breeze Airways and Delta are the top three most popular airlines that fly to Florence, South Carolina from Syracuse according to our data. American Airlines is the first choice among our users, with 52% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 8 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Syracuse to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to Florence, South Carolina (SYR to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Florence, South Carolina

Fastest flight time

3h 58m

Direct flights

None
The fastest flight from Syracuse to Florence, South Carolina takes 3h 58m
There are no direct flights from Syracuse to Florence, South Carolina. There are no popular flight routes from Syracuse to Florence, South Carolina.
Search flight deals

  • How far is Syracuse Hancock Intl to Florence by plane?

    The straight-line distance from Syracuse Hancock Intl to Florence is 641.4 mi. In terms of flight time, this usually takes a little over 3h 58m.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Florence Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Syracuse Hancock Intl Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Darlington
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Syracuse to Florence for you.

Can I find flights from Syracuse to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Syracuse which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Syracuse to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Syracuse to Florence.

I’m not ready to book a flight from Syracuse to Florence right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florence from Syracuse. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Florence, South Carolina trip

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