Latest deals
Insights
When to book
FAQs
Price Alerts

Cheap flights from Syracuse to Florence from $368

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Florence departing on 10/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Syracuse to Florence

Cheap round-trip flights

American Airlines Logo
5:32 am - 5:12 pmSYR-FLO
11h 40m2 stops
American Airlines Logo
5:14 am - 4:50 pmFLO-SYR
11h 36m2 stops
$368American Airlines
Find Deal
Sat, Oct 4 - Sat, Oct 18
American Airlines Logo
11:48 am - 11:02 pmSYR-FLO
11h 14m2 stops
American Airlines Logo
5:09 am - 5:10 pmFLO-SYR
12h 01m2 stops
$388American Airlines
Find Deal
Tue, Aug 12 - Sat, Aug 16
American Airlines Logo
6:47 pm - 11:16 pmSYR-FLO
4h 29m1 stop
American Airlines Logo
11:11 am - 4:39 pmFLO-SYR
5h 28m1 stop
$413American Airlines
Find Deal
Sat, Oct 4 - Sat, Oct 18
American Airlines Logo
6:47 pm - 11:16 pmSYR-FLO
4h 29m1 stop
American Airlines Logo
5:14 am - 2:25 pmFLO-SYR
9h 11m2 stops
$418American Airlines
Find Deal
Sat, Oct 4 - Sat, Oct 18
American Airlines Logo
4:47 pm - 11:02 pmSYR-FLO
6h 15m1 stop
American Airlines Logo
5:09 am - 2:13 pmFLO-SYR
9h 04m2 stops
$434American Airlines
Find Deal
Tue, Aug 12 - Sat, Aug 16
American Airlines Logo
4:47 pm - 11:02 pmSYR-FLO
6h 15m1 stop
American Airlines Logo
11:15 am - 4:29 pmFLO-SYR
5h 14m1 stop
$464American Airlines
Find Deal
Tue, Aug 12 - Sat, Aug 16
American Airlines Logo
2:38 pm - 11:02 pmSYR-FLO
8h 24m2 stops
American Airlines Logo
5:09 am - 11:20 amFLO-SYR
6h 11m1 stop
$608American Airlines
Find Deal
Mon, Aug 11 - Sun, Aug 17
American Airlines Logo
2:38 pm - 11:02 pmSYR-FLO
8h 24m2 stops
American Airlines Logo
5:09 am - 2:13 pmFLO-SYR
9h 04m2 stops
$617American Airlines
Find Deal
Mon, Aug 11 - Sun, Aug 17
American Airlines Logo
4:47 pm - 11:02 pmSYR-FLO
6h 15m1 stop
American Airlines Logo
5:09 am - 11:20 amFLO-SYR
6h 11m1 stop
$634American Airlines
Find Deal
Mon, Aug 11 - Sun, Aug 17

American Airlines flights from Syracuse to Florence, South Carolina

Our best American Airlines deals on Syracuse to Florence, South Carolina flight tickets
American Airlines
Oct 4
SYR5:32 amSyracuse Hancock Intl
11h 40m
2 stops
FLO5:12 pmFlorence
Oct 18
FLO5:14 amFlorence
11h 36m
2 stops
SYR4:50 pmSyracuse Hancock Intl
$368
Find similar
American Airlines
Aug 12
SYR11:48 amSyracuse Hancock Intl
11h 14m
2 stops
FLO11:02 pmFlorence
Aug 16
FLO5:09 amFlorence
12h 01m
2 stops
SYR5:10 pmSyracuse Hancock Intl
$388
Find similar
American Airlines
Oct 4
SYR6:47 pmSyracuse Hancock Intl
4h 29m
1 stop
FLO11:16 pmFlorence
Oct 18
FLO11:11 amFlorence
5h 28m
1 stop
SYR4:39 pmSyracuse Hancock Intl
$413
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Syracuse to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Sat 10/4

5:32 am-5:12 pm

2 stops11h 40m

Florence

Sat 10/18

5:14 am-4:50 pm

2 stops11h 36m

$368

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Tue 8/12

11:48 am-11:02 pm

2 stops11h 14m

Florence

Sat 8/16

5:09 am-5:10 pm

2 stops12h 01m

$388

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Sat 10/4

6:47 pm-11:16 pm

1 stop4h 29m

Florence

Sat 10/18

11:11 am-4:39 pm

1 stop5h 28m

$413

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Sat 10/4

6:47 pm-11:16 pm

1 stop4h 29m

Florence

Sat 10/18

5:14 am-2:25 pm

2 stops9h 11m

$418

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Tue 8/12

4:47 pm-11:02 pm

1 stop6h 15m

Florence

Sat 8/16

5:09 am-2:13 pm

2 stops9h 04m

$434

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Tue 8/12

4:47 pm-11:02 pm

1 stop6h 15m

Florence

Sat 8/16

11:15 am-4:29 pm

1 stop5h 14m

$464

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Mon 8/11

2:38 pm-11:02 pm

2 stops8h 24m

Florence

Sun 8/17

5:09 am-11:20 am

1 stop6h 11m

$608

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Mon 8/11

2:38 pm-11:02 pm

2 stops8h 24m

Florence

Sun 8/17

5:09 am-2:13 pm

2 stops9h 04m

$617

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Mon 8/11

4:47 pm-11:02 pm

1 stop6h 15m

Florence

Sun 8/17

5:09 am-11:20 am

1 stop6h 11m

$634

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Syracuse to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, Delta and Breeze Airways are the top three most popular airlines that fly to Florence, South Carolina from Syracuse according to our data. American Airlines is the first choice among our users, with 66% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 9 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Syracuse to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to Florence, South Carolina (SYR to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Florence, South Carolina

Best Price Found

$368

Fastest flight time

4h 29m

Direct flights

None

Airports in Florence, South Carolina

1 airport
The best flight deal from Syracuse to Florence, South Carolina found on momondo in the last 72 hours is $368
The fastest flight from Syracuse to Florence, South Carolina takes 4h 29m
There are no direct flights from Syracuse to Florence, South Carolina. Popular non-direct route for this connection is Syracuse Hancock Intl Airport - Florence Airport.
There is 1 airport near Florence, South Carolina: Florence (FLO)
Search flight deals

  • How far is Syracuse Hancock Intl to Florence by plane?

    The straight-line distance from Syracuse Hancock Intl to Florence is 641.4 mi. In terms of flight time, this usually takes a little over 4h 29m.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Florence Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Syracuse Hancock Intl Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Syracuse to Florence for you.

Can I find flights from Syracuse to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Syracuse which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Syracuse to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Syracuse to Florence.

I’m not ready to book a flight from Syracuse to Florence right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florence from Syracuse. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Florence, South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sun 8/3
Sun 8/10
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States