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Cheap flights from Syracuse to Florence from $447

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to Florence departing on 10/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Syracuse to Florence

Cheap round-trip flights

American Airlines Logo
5:29 pm - 12:03 amSYR-FLO
6h 34m1 stop
American Airlines Logo
10:29 am - 2:15 pmFLO-SYR
3h 46m1 stop
$447American Airlines
Find Deal
Sun, Oct 26 - Wed, Nov 5
American Airlines Logo
5:29 pm - 12:03 amSYR-FLO
6h 34m1 stop
American Airlines Logo
6:15 am - 2:58 pmFLO-SYR
8h 43m2 stops
$452American Airlines
Find Deal
Sun, Oct 26 - Wed, Nov 5
American Airlines Logo
6:00 am - 2:04 pmSYR-FLO
8h 04m2 stops
American Airlines Logo
6:15 am - 2:58 pmFLO-SYR
8h 43m2 stops
$481American Airlines
Find Deal
Sun, Oct 26 - Wed, Nov 5
American Airlines Logo
1:44 pm - 12:03 amSYR-FLO
10h 19m2 stops
American Airlines Logo
6:15 am - 2:58 pmFLO-SYR
8h 43m2 stops
$555American Airlines
Find Deal
Sun, Oct 26 - Wed, Nov 5

American Airlines flights from Syracuse to Florence, South Carolina

Our best American Airlines deals on Syracuse to Florence, South Carolina flight tickets
American Airlines
Oct 26
SYR5:29 pmSyracuse Hancock Intl
6h 34m
1 stop
FLO12:03 amFlorence
Nov 5
FLO10:29 amFlorence
3h 46m
1 stop
SYR2:15 pmSyracuse Hancock Intl
$447
Find similar
American Airlines
Oct 26
SYR5:29 pmSyracuse Hancock Intl
6h 34m
1 stop
FLO12:03 amFlorence
Nov 5
FLO6:15 amFlorence
8h 43m
2 stops
SYR2:58 pmSyracuse Hancock Intl
$452
Find similar
American Airlines
Oct 26
SYR6:00 amSyracuse Hancock Intl
8h 04m
2 stops
FLO2:04 pmFlorence
Nov 5
FLO6:15 amFlorence
8h 43m
2 stops
SYR2:58 pmSyracuse Hancock Intl
$481
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Syracuse to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Sun 10/26

5:29 pm-12:03 am

1 stop6h 34m

Florence

Wed 11/5

10:29 am-2:15 pm

1 stop3h 46m

$447

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Sun 10/26

5:29 pm-12:03 am

1 stop6h 34m

Florence

Wed 11/5

6:15 am-2:58 pm

2 stops8h 43m

$452

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Sun 10/26

6:00 am-2:04 pm

2 stops8h 04m

Florence

Wed 11/5

6:15 am-2:58 pm

2 stops8h 43m

$481

SyracuseFlorence

SYR - FLO

SYRFLO

Syracuse Hancock Intl

Sun 10/26

1:44 pm-12:03 am

2 stops10h 19m

Florence

Wed 11/5

6:15 am-2:58 pm

2 stops8h 43m

$555

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

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How to get the cheapest flight ticket from Syracuse to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, Delta and Breeze Airways are the top three most popular airlines that fly to Florence, South Carolina from Syracuse according to our data. American Airlines is the first choice among our users, with 62% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 9 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Syracuse to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to Florence, South Carolina (SYR to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to Florence, South Carolina

Direct flights

None
There are no direct flights from Syracuse to Florence, South Carolina. There are no popular flight routes from Syracuse to Florence, South Carolina.
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  • How far is Syracuse Hancock Intl to Florence by plane?

    The straight-line distance from Syracuse Hancock Intl to Florence is 641.4 mi. In terms of flight time, this usually takes a little over 6h 34m.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Florence Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Florence Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Florence Airport?

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Syracuse Hancock Intl Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Syracuse to Florence, South Carolina?

Best airlines flying from Syracuse to Florence, South Carolina

Compare and see reviews for airlines that fly from Syracuse to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $379Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Syracuse to Florence for you.

Can I find flights from Syracuse to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Syracuse which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Syracuse to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Syracuse to Florence.

I’m not ready to book a flight from Syracuse to Florence right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florence from Syracuse. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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