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Cheap flights from St. Louis to Boston from $266

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Boston departing on 1/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from St. Louis to Boston

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:59 pm - 11:50 pm
STL
-
MHT
4h 51m1 stop
American Airlines Logo
5:01 pm - 9:51 pm
MHT
-
STL
5h 50m1 stop
$319American Airlines
Wed, Jan 14 - Mon, Jan 19
Southwest Logo
11:35 am - 10:05 pm
STL
-
MHT
9h 30m2 stops
Southwest Logo
5:00 am - 9:35 am
MHT
-
STL
5h 35m1 stop
$347Southwest
Wed, Jan 14 - Mon, Jan 19
Southwest Logo
5:00 am - 12:35 pm
STL
-
MHT
6h 35m1 stop
Southwest Logo
7:30 am - 11:30 am
MHT
-
STL
5h 00m1 stop
$377Southwest
Thu, Apr 16 - Wed, Apr 22
Southwest Logo
6:05 am - 2:50 pm
STL
-
MHT
7h 45m2 stops
Southwest Logo
7:40 am - 2:10 pm
MHT
-
STL
7h 30m2 stops
$380Southwest
Wed, Jan 14 - Mon, Jan 19
Southwest Logo
9:55 am - 6:30 pm
STL
-
MHT
7h 35m2 stops
Southwest Logo
7:30 am - 11:30 am
MHT
-
STL
5h 00m1 stop
$382Southwest
Thu, Apr 16 - Wed, Apr 22
United Airlines Logo
7:45 am - 6:59 pm
STL
-
MHT
10h 14m2 stops
United Airlines Logo
2:33 pm - 11:50 pm
MHT
-
STL
10h 17m2 stops
$387United Airlines
Thu, Apr 16 - Wed, Apr 22
American Airlines Logo
5:00 am - 12:05 pm
STL
-
MHT
6h 05m1 stop
American Airlines Logo
6:00 am - 1:14 pm
MHT
-
STL
8h 14m1 stop
$402American Airlines
Wed, Dec 31 - Sun, Jan 4
Southwest Logo
7:45 pm - 8:00 am
STL
-
MHT
11h 15m1 stop
Southwest Logo
7:10 pm - 10:45 pm
MHT
-
STL
4h 35m1 stop
$412Southwest
Fri, May 1 - Mon, May 4
Southwest Logo
7:45 pm - 8:00 am
STL
-
MHT
11h 15m1 stop
Southwest Logo
6:20 am - 3:25 pm
MHT
-
STL
10h 05m2 stops
$418Southwest
Fri, May 1 - Mon, May 4
United Airlines Logo
8:30 am - 1:58 pm
STL
-
MHT
4h 28m1 stop
United Airlines Logo
2:33 pm - 11:50 pm
MHT
-
STL
10h 17m2 stops
$432United Airlines
Tue, Apr 7 - Tue, Apr 14

American Airlines flights from St. Louis to Manchester, New Hampshire

Our best American Airlines deals on St. Louis to Manchester, New Hampshire flight tickets
American Airlines
Jan 14
STL5:59 pmLambert-St Louis
4h 51m
1 stop
MHT11:50 pmManchester
Jan 19
MHT5:01 pmManchester
5h 50m
1 stop
STL9:51 pmLambert-St Louis
$319
Find similar
American Airlines
Dec 31
STL5:00 amLambert-St Louis
6h 05m
1 stop
MHT12:05 pmManchester
Jan 4
MHT6:00 amManchester
8h 14m
1 stop
STL1:14 pmLambert-St Louis
$402
Find similar
American Airlines
May 15
STL6:28 amLambert-St Louis
4h 10m
1 stop
MHT11:38 amManchester
May 18
MHT5:47 amManchester
4h 53m
1 stop
STL9:40 amLambert-St Louis
$452
Find similar

Southwest flights from St. Louis to Manchester, New Hampshire

Our best Southwest deals on St. Louis to Manchester, New Hampshire flight tickets
Southwest
Jan 14
STL11:35 amLambert-St Louis
9h 30m
2 stops
MHT10:05 pmManchester
Jan 19
MHT5:00 amManchester
5h 35m
1 stop
STL9:35 amLambert-St Louis
$347
Find similar
Southwest
Apr 16
STL5:00 amLambert-St Louis
6h 35m
1 stop
MHT12:35 pmManchester
Apr 22
MHT7:30 amManchester
5h 00m
1 stop
STL11:30 amLambert-St Louis
$377
Find similar
Southwest
Jan 14
STL6:05 amLambert-St Louis
7h 45m
2 stops
MHT2:50 pmManchester
Jan 19
MHT7:40 amManchester
7h 30m
2 stops
STL2:10 pmLambert-St Louis
$380
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Manchester, New Hampshire that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from St. Louis to Manchester, New Hampshire that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisManchester

STL - MHT

STLMHT

Lambert-St Louis

Wed 1/14

5:59 pm-11:50 pm

1 stop4h 51m

Manchester

Mon 1/19

5:01 pm-9:51 pm

1 stop5h 50m

$319

St. LouisManchester

STL - MHT

STLMHT

Lambert-St Louis

Wed 1/14

11:35 am-10:05 pm

2 stops9h 30m

Manchester

Mon 1/19

5:00 am-9:35 am

1 stop5h 35m

$347

St. LouisManchester

STL - MHT

STLMHT

Lambert-St Louis

Thu 4/16

5:00 am-12:35 pm

1 stop6h 35m

Manchester

Wed 4/22

7:30 am-11:30 am

1 stop5h 00m

$377

St. LouisManchester

STL - MHT

STLMHT

Lambert-St Louis

Wed 1/14

6:05 am-2:50 pm

2 stops7h 45m

Manchester

Mon 1/19

7:40 am-2:10 pm

2 stops7h 30m

$380

St. LouisManchester

STL - MHT

STLMHT

Lambert-St Louis

Thu 4/16

9:55 am-6:30 pm

2 stops7h 35m

Manchester

Wed 4/22

7:30 am-11:30 am

1 stop5h 00m

$382

St. LouisManchester

STL - MHT

STLMHT

Lambert-St Louis

Thu 4/16

7:45 am-6:59 pm

2 stops10h 14m

Manchester

Wed 4/22

2:33 pm-11:50 pm

2 stops10h 17m

$387

St. LouisManchester

STL - MHT

STLMHT

Lambert-St Louis

Wed 12/31

5:00 am-12:05 pm

1 stop6h 05m

Manchester

Sun 1/4

6:00 am-1:14 pm

1 stop8h 14m

$402

St. LouisManchester

STL - MHT

STLMHT

Lambert-St Louis

Fri 5/1

7:45 pm-8:00 am

1 stop11h 15m

Manchester

Mon 5/4

7:10 pm-10:45 pm

1 stop4h 35m

$412

St. LouisManchester

STL - MHT

STLMHT

Lambert-St Louis

Fri 5/1

7:45 pm-8:00 am

1 stop11h 15m

Manchester

Mon 5/4

6:20 am-3:25 pm

2 stops10h 05m

$418

St. LouisManchester

STL - MHT

STLMHT

Lambert-St Louis

Tue 4/7

8:30 am-1:58 pm

1 stop4h 28m

Manchester

Tue 4/14

2:33 pm-11:50 pm

2 stops10h 17m

$432

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Boston from

How to get the cheapest flight ticket from St. Louis to Manchester, New Hampshire

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Manchester, New Hampshire?

If you aren’t able to travel during the month of May, then book flights to Manchester, New Hampshire from St. Louis during August instead. Flights to Manchester, New Hampshire in August, while not as cheap as those in May, still average around $276.

What is the cheapest day to depart on your flight to Manchester, New Hampshire?

Our data shows that Tuesday is the least expensive day to fly to Manchester, New Hampshire. Tickets to fly out on this day can be as low as $337. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Manchester, New Hampshire on Saturday is $481.

What is the cheapest time of day to depart on your flight to Manchester, New Hampshire?

Our most recent data shows that the best time of day to fly to Manchester, New Hampshire is at noon. Flights from St. Louis to Manchester, New Hampshire during this time can be as low as $345. Flights in the afternoon are often more expensive with an average ticket price of $436.

Can stopping save me money on St. Louis to Manchester, New Hampshire flights?

You could potentially save up to 49% on your flight if you consider stops on a St. Louis to Manchester, New Hampshire flight.

How have St. Louis to Manchester, New Hampshire flight prices changed over time?

As of December 2025, prices for St. Louis to Manchester, New Hampshire flights are approximately 64% cheaper when compared to flights at the same time last year.

When to book flights from St. Louis to Manchester, New Hampshire

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Manchester, New Hampshire according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Manchester, New Hampshire (STL to MHT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Manchester, New Hampshire

Fastest flight time

4h 15m

Direct flights

None
The fastest flight from St. Louis to Manchester, New Hampshire takes 4h 15m
There are no direct flights from St. Louis to Manchester, New Hampshire. There are no popular flight routes from St. Louis to Manchester, New Hampshire.
Search flight deals

  • How far is Lambert-St Louis to Manchester by plane?

    The straight-line distance from Lambert-St Louis to Manchester is 1022.3 mi. Flights usually cover this in 4h 15m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Manchester Airport?

    Prices for flights from Lambert-St Louis Airport to Manchester Airport are updated daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Manchester Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Manchester Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Manchester Airport.

  • What documentation or ID do you need to fly to Manchester Airport?

    The travel and health documents you'll need for your trip to Manchester Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Manchester Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Manchester, New Hampshire?

Best airlines flying from St. Louis to Manchester, New Hampshire

Compare and see reviews for airlines that fly from St. Louis to Manchester, New Hampshire with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $200Free CancellationRating
7.9
4,250 reviews
Search Southwest flights
American AirlinesPriceFrom $256Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights

Traveling to a place near Boston?

Book flights to Boston if you plan to visit one of these locations
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Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Manchester?

It is quick and easy to find St. Louis to Manchester flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Manchester that suits you.

Can I find flights from St. Louis to Manchester with flexible booking policies on momondo?

Yes. All flights to Manchester from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from St. Louis to Manchester?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Manchester from St. Louis.

I’m not ready to book a flight from St. Louis to Manchester right now. Can momondo alert me if prices change?

Price alerts on flights to Manchester from St. Louis are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Manchester, New Hampshire trip

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