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Cheap flights from St. Louis to Knoxville from $113

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Knoxville departing on 2/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from St. Louis to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:20 pm - 10:09 pm
STL
-
TYS
5h 49m1 stop
American Airlines Logo
4:00 pm - 9:51 pm
TYS
-
STL
6h 51m2 stops
$230American Airlines
Tue, Jan 13 - Tue, Jan 20
Multiple Airlines Logo
3:43 pm - 10:10 am
STL
-
TYS
17h 27m2 stops
Multiple Airlines Logo
12:30 pm - 10:33 pm
TYS
-
STL
11h 03m1 stop
$247Multiple Airlines
Thu, Jan 8 - Sat, Jan 10
American Airlines Logo
5:14 am - 11:27 am
STL
-
TYS
5h 13m1 stop
American Airlines Logo
5:00 am - 8:32 am
TYS
-
STL
4h 32m1 stop
$249American Airlines
Wed, Feb 18 - Sun, Feb 22
American Airlines Logo
10:17 am - 3:20 pm
STL
-
TYS
4h 03m1 stop
American Airlines Logo
6:51 pm - 10:59 pm
TYS
-
STL
5h 08m1 stop
$251American Airlines
Tue, Jan 13 - Tue, Jan 20
Multiple Airlines Logo
5:11 pm - 10:10 am
STL
-
TYS
15h 59m1 stop
Multiple Airlines Logo
12:30 pm - 10:33 pm
TYS
-
STL
11h 03m1 stop
$252Multiple Airlines
Thu, Jan 8 - Sat, Jan 10
Multiple Airlines Logo
3:43 pm - 1:40 pm
STL
-
TYS
20h 57m2 stops
Multiple Airlines Logo
12:30 pm - 10:33 pm
TYS
-
STL
11h 03m1 stop
$253Multiple Airlines
Thu, Jan 8 - Sat, Jan 10
Multiple Airlines Logo
5:11 pm - 10:10 am
STL
-
TYS
15h 59m1 stop
Multiple Airlines Logo
12:30 pm - 10:33 pm
TYS
-
STL
11h 03m1 stop
$257Multiple Airlines
Thu, Jan 8 - Sat, Jan 10
Delta Logo
6:00 am - 11:08 am
STL
-
TYS
4h 08m1 stop
Delta Logo
5:40 am - 8:53 am
TYS
-
STL
4h 13m1 stop
$265Delta
Wed, Jan 28 - Fri, Jan 30
American Airlines Logo
6:00 am - 2:32 pm
STL
-
TYS
7h 32m1 stop
American Airlines Logo
5:14 pm - 11:12 pm
TYS
-
STL
6h 58m1 stop
$279American Airlines
Fri, Feb 6 - Mon, Feb 9
Multiple Airlines Logo
9:32 pm - 3:35 pm
STL
-
TYS
17h 03m2 stops
Multiple Airlines Logo
12:55 pm - 11:33 pm
TYS
-
STL
11h 38m1 stop
$293Multiple Airlines
Sun, Feb 1 - Fri, Feb 6

American Airlines flights from St. Louis to Knoxville

Our best American Airlines deals on St. Louis to Knoxville flight tickets
American Airlines
Feb 18
STL5:14 amLambert-St Louis
5h 13m
1 stop
TYS11:27 amKnoxville McGhee Tyson
Feb 22
TYS5:00 amKnoxville McGhee Tyson
4h 32m
1 stop
STL8:32 amLambert-St Louis
$249
Find similar
American Airlines
Jan 13
STL3:20 pmLambert-St Louis
6h 34m
2 stops
TYS10:54 pmKnoxville McGhee Tyson
Jan 17
TYS7:11 pmKnoxville McGhee Tyson
5h 15m
1 stop
STL11:26 pmLambert-St Louis
$274
Find similar
American Airlines
Feb 6
STL9:54 amLambert-St Louis
5h 02m
1 stop
TYS3:56 pmKnoxville McGhee Tyson
Feb 9
TYS5:14 pmKnoxville McGhee Tyson
6h 58m
1 stop
STL11:12 pmLambert-St Louis
$279
Find similar

Delta flights from St. Louis to Knoxville

Our best Delta deals on St. Louis to Knoxville flight tickets
Delta
Jan 28
STL6:00 amLambert-St Louis
4h 08m
1 stop
TYS11:08 amKnoxville McGhee Tyson
Jan 30
TYS5:40 amKnoxville McGhee Tyson
4h 13m
1 stop
STL8:53 amLambert-St Louis
$265
Find similar
Delta
Feb 18
STL6:00 amLambert-St Louis
4h 08m
1 stop
TYS11:08 amKnoxville McGhee Tyson
Feb 22
TYS6:55 amKnoxville McGhee Tyson
5h 07m
1 stop
STL11:02 amLambert-St Louis
$403
Find similar
Delta
Dec 19
STL9:30 amLambert-St Louis
4h 21m
1 stop
TYS2:51 pmKnoxville McGhee Tyson
Dec 21
TYS8:35 amKnoxville McGhee Tyson
4h 46m
1 stop
STL12:21 pmLambert-St Louis
$547
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 1/13

3:20 pm-10:09 pm

1 stop5h 49m

Knoxville McGhee Tyson

Tue 1/20

4:00 pm-9:51 pm

2 stops6h 51m

$230

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 1/8

3:43 pm-10:10 am

2 stops17h 27m

Knoxville McGhee Tyson

Sat 1/10

12:30 pm-10:33 pm

1 stop11h 03m

$247

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 2/18

5:14 am-11:27 am

1 stop5h 13m

Knoxville McGhee Tyson

Sun 2/22

5:00 am-8:32 am

1 stop4h 32m

$249

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 1/13

10:17 am-3:20 pm

1 stop4h 03m

Knoxville McGhee Tyson

Tue 1/20

6:51 pm-10:59 pm

1 stop5h 08m

$251

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 1/8

5:11 pm-10:10 am

1 stop15h 59m

Knoxville McGhee Tyson

Sat 1/10

12:30 pm-10:33 pm

1 stop11h 03m

$252

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 1/8

3:43 pm-1:40 pm

2 stops20h 57m

Knoxville McGhee Tyson

Sat 1/10

12:30 pm-10:33 pm

1 stop11h 03m

$253

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 1/8

5:11 pm-10:10 am

1 stop15h 59m

Knoxville McGhee Tyson

Sat 1/10

12:30 pm-10:33 pm

1 stop11h 03m

$257

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 1/28

6:00 am-11:08 am

1 stop4h 08m

Knoxville McGhee Tyson

Fri 1/30

5:40 am-8:53 am

1 stop4h 13m

$265

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 2/6

6:00 am-2:32 pm

1 stop7h 32m

Knoxville McGhee Tyson

Mon 2/9

5:14 pm-11:12 pm

1 stop6h 58m

$279

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 2/1

9:32 pm-3:35 pm

2 stops17h 03m

Knoxville McGhee Tyson

Fri 2/6

12:55 pm-11:33 pm

1 stop11h 38m

$293

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from St. Louis to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from St. Louis, with most prices found around $266. If you aren’t able to travel during the month of July, then book flights to Knoxville from St. Louis during April instead. Flights to Knoxville in April, while not as cheap as those in July, still average around $273.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from St. Louis to Knoxville is on a Thursday. Travelers who choose to depart for Knoxville on a Thursday will often find tickets for as low as $274. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from St. Louis to Knoxville for around $518.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from St. Louis to Knoxville when you can find flight prices for as low as $280. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $388.

How have St. Louis to Knoxville flight prices changed over time?

As of December 2025, prices for St. Louis to Knoxville flights are approximately 22% cheaper when compared to flights at the same time last year.

When to book flights from St. Louis to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Knoxville (STL to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Knoxville

Fastest flight time

3h 14m

Direct flights

None
The fastest flight from St. Louis to Knoxville takes 3h 14m
There are no direct flights from St. Louis to Knoxville. There are no popular flight routes from St. Louis to Knoxville.
Search flight deals

  • How far is Lambert-St Louis to Knoxville McGhee Tyson by plane?

    Lambert-St Louis and Knoxville McGhee Tyson are 390.7 mi apart from one another. Flights usually cover this in 3h 14m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Knoxville?

Best airlines flying from St. Louis to Knoxville

Compare and see reviews for airlines that fly from St. Louis to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $213Free CancellationRating
7.4
9,091 reviews
Search United Airlines flights
American AirlinesPriceFrom $213Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights
DeltaPriceFrom $222Free CancellationRating
7.9
8,005 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from St. Louis to Knoxville?

momondo helps you find the best flight between St. Louis and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from St. Louis to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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