Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from St. Louis to Knoxville from $122

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
11:37 am - 4:37 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
4h 00m1 stop Chicago O'Hare Intl
American Airlines Logo
5:32 pm - 10:20 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
5h 48m1 stop Dallas/Fort Worth
$243American Airlines
Fri, Dec 4 - Mon, Dec 7
American Airlines Logo
11:37 am - 7:05 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
6h 28m1 stop Chicago O'Hare Intl
American Airlines Logo
7:25 pm - 10:42 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
4h 17m1 stop Charlotte Douglas
$282American Airlines
Thu, Dec 3 - Sat, Dec 5
United Airlines Logo
9:05 am - 4:54 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
6h 49m1 stop Chicago O'Hare Intl
United Airlines Logo
5:55 pm - 9:37 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
4h 42m1 stop Chicago O'Hare Intl
$307United Airlines
Mon, Jan 11 - Fri, Jan 15
American Airlines Logo
11:09 am - 4:16 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
4h 07m1 stop Charlotte Douglas
American Airlines Logo
6:38 am - 10:19 amTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
4h 41m1 stop Charlotte Douglas
$307American Airlines
Fri, Dec 25 - Thu, Dec 31
Multiple Airlines Logo
5:58 pm - 12:04 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
17h 06m1 stop Orlando
Multiple Airlines Logo
7:30 am - 10:53 amTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
28h 23m2 stops Orlando Sanford Intl Atlanta Hartsfield-Jackson
$310Multiple Airlines
Thu, Dec 24 - Thu, Dec 31
Multiple Airlines Logo
12:02 pm - 10:37 amSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
21h 35m2 stops Atlanta Hartsfield-Jackson Fort Lauderdale
Multiple Airlines Logo
9:00 am - 12:12 amTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
16h 12m1 stop Orlando
$317Multiple Airlines
Fri, Dec 4 - Mon, Dec 7
Southwest Logo
12:40 pm - 8:50 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
7h 10m1 stop Baltimore/Washington
Southwest Logo
7:55 am - 7:25 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
12h 30m2 stops Baltimore/Washington Pittsburgh
$318Southwest
Fri, Dec 25 - Thu, Dec 31
Southwest Logo
12:40 pm - 8:50 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
7h 10m1 stop Baltimore/Washington
Southwest Logo
7:10 am - 4:15 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
10h 05m2 stops Nashville Intl Tampa
$322Southwest
Thu, Dec 3 - Sat, Dec 5
Delta Logo
6:49 pm - 11:57 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
4h 08m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:51 pm - 9:40 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
3h 49m1 stop Atlanta Hartsfield-Jackson
$328Delta
Fri, Feb 19 - Sun, Feb 21
Delta Logo
5:41 pm - 11:58 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
5h 17m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:15 am - 9:17 amTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
5h 02m1 stop Atlanta Hartsfield-Jackson
$328Delta
Fri, Jan 8 - Sun, Jan 10

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

United Airlines flights from St. Louis to Knoxville

Our best United Airlines deals on St. Louis to Knoxville flight tickets
United Airlines
Feb 1
STL3:03 pmLambert-St Louis
5h 02m
1 stop
TYS9:05 pmKnoxville McGhee Tyson
Feb 5
TYS11:53 amKnoxville McGhee Tyson
5h 50m
1 stop
STL4:43 pmLambert-St Louis
$333
United Airlines
Dec 18
STL8:22 amLambert-St Louis
5h 20m
1 stop
TYS2:42 pmKnoxville McGhee Tyson
Dec 21
TYS6:00 amKnoxville McGhee Tyson
7h 26m
1 stop
STL12:26 pmLambert-St Louis
$352
United Airlines
Dec 25
STL1:20 pmLambert-St Louis
5h 29m
1 stop
TYS7:49 pmKnoxville McGhee Tyson
Dec 30
TYS6:00 amKnoxville McGhee Tyson
7h 26m
1 stop
STL12:26 pmLambert-St Louis
$382

American Airlines flights from St. Louis to Knoxville

Our best American Airlines deals on St. Louis to Knoxville flight tickets
American Airlines
Dec 3
STL11:37 amLambert-St Louis
6h 28m
1 stop
TYS7:05 pmKnoxville McGhee Tyson
Dec 5
TYS7:25 pmKnoxville McGhee Tyson
4h 17m
1 stop
STL10:42 pmLambert-St Louis
$282
American Airlines
Dec 25
STL11:09 amLambert-St Louis
4h 07m
1 stop
TYS4:16 pmKnoxville McGhee Tyson
Dec 31
TYS6:38 amKnoxville McGhee Tyson
4h 41m
1 stop
STL10:19 amLambert-St Louis
$307
American Airlines
Nov 25
STL2:48 pmLambert-St Louis
7h 44m
1 stop
TYS11:32 pmKnoxville McGhee Tyson
Nov 30
TYS8:04 pmKnoxville McGhee Tyson
4h 54m
1 stop
STL11:58 pmLambert-St Louis
$457

momondo Fare Finder

 
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Fri 12/4

11:37 am-4:37 pm

1 stop4h 00m

Knoxville McGhee Tyson

Mon 12/7

5:32 pm-10:20 pm

1 stop5h 48m

$243

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Thu 12/3

11:37 am-7:05 pm

1 stop6h 28m

Knoxville McGhee Tyson

Sat 12/5

7:25 pm-10:42 pm

1 stop4h 17m

$282

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Mon 1/11

9:05 am-4:54 pm

1 stop6h 49m

Knoxville McGhee Tyson

Fri 1/15

5:55 pm-9:37 pm

1 stop4h 42m

$307

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Fri 12/25

11:09 am-4:16 pm

1 stop4h 07m

Knoxville McGhee Tyson

Thu 12/31

6:38 am-10:19 am

1 stop4h 41m

$307

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Thu 12/24

5:58 pm-12:04 pm

1 stop17h 06m

Knoxville McGhee Tyson

Thu 12/31

7:30 am-10:53 am

2 stops28h 23m

$310

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Fri 12/4

12:02 pm-10:37 am

2 stops21h 35m

Knoxville McGhee Tyson

Mon 12/7

9:00 am-12:12 am

1 stop16h 12m

$317

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Fri 12/25

12:40 pm-8:50 pm

1 stop7h 10m

Knoxville McGhee Tyson

Thu 12/31

7:55 am-7:25 pm

2 stops12h 30m

$318

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Thu 12/3

12:40 pm-8:50 pm

1 stop7h 10m

Knoxville McGhee Tyson

Sat 12/5

7:10 am-4:15 pm

2 stops10h 05m

$322
Quickest round-trip

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Fri 2/19

6:49 pm-11:57 pm

1 stop4h 08m

Knoxville McGhee Tyson

Sun 2/21

6:51 pm-9:40 pm

1 stop3h 49m

$328

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Fri 1/8

5:41 pm-11:58 pm

1 stop5h 17m

Knoxville McGhee Tyson

Sun 1/10

5:15 am-9:17 am

1 stop5h 02m

$328

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Knoxville from

How to get the cheapest flight ticket from St. Louis to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $343 to $491.
The lowest price recently found on this route was $243.

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from St. Louis, with most prices found around $278. If you aren’t able to travel during the month of August, then book flights to Knoxville from St. Louis during April instead. Flights to Knoxville in April, while not as cheap as those in August, still average around $304.

Can stopping save me money on St. Louis to Knoxville flights?

You could potentially save up to 32% on your flight if you consider stops on a St. Louis to Knoxville flight.

How have St. Louis to Knoxville flight prices changed over time?

As of November 2026, prices for St. Louis to Knoxville flights are approximately 31% more expensive when compared to flights at the same time last year.

When to book flights from St. Louis to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Knoxville (STL to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Knoxville

Best Price Found

$122

Fastest flight time

3h 44m

Direct flights

None
The best one-way flight to Knoxville from St. Louis in the past 72 hours is $122. The best round-trip flight deal from St. Louis to Knoxville found on momondo in the last 72 hours is $243.
The fastest flight from St. Louis to Knoxville takes 3h 44m
There are no direct flights from St. Louis to Knoxville. There are no popular flight routes from St. Louis to Knoxville.
Search flight deals

Frequently asked questions about flying from St. Louis to Knoxville

  • How far is Lambert-St Louis to Knoxville McGhee Tyson by plane?

    Lambert-St Louis and Knoxville McGhee Tyson are 390.7 mi apart from one another. Flights usually cover this in 3h 44m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Knoxville?

Best airlines flying from St. Louis to Knoxville

Compare and see reviews for airlines that fly from St. Louis to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $210Free CancellationRating
7.0
12,227 reviews
Search American Airlines flights
DeltaPriceFrom $210Free CancellationRating
7.8
8,700 reviews
Search Delta flights
SouthwestPriceFrom $248Free CancellationRating
8.0
4,219 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Kodak
Oak Ridge
Newport
Lenoir City
Dandridge
Clinton
Rockford
Jefferson City

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from St. Louis to Knoxville?

momondo helps you find the best flight between St. Louis and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from St. Louis to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 12/9
Wed 12/16
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States