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Cheap flights from St. Louis to Knoxville from $114

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Knoxville departing on 11/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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Frontier Logo
7:45 pm - 6:22 pmSTL-TYS
21h 37m1 stop
Frontier Logo
7:07 pm - 9:07 amTYS-STL
15h 00m1 stop
$198Frontier
Find Deal
Wed, Nov 12 - Sun, Nov 16
Frontier Logo
7:57 pm - 3:53 pmSTL-TYS
18h 56m1 stop
Frontier Logo
4:52 pm - 10:14 amTYS-STL
18h 22m1 stop
$239Frontier
Find Deal
Thu, Nov 27 - Thu, Dec 4
Multiple Airlines Logo
2:47 pm - 8:33 amSTL-TYS
16h 46m1 stop
Multiple Airlines Logo
2:53 pm - 10:56 amTYS-STL
21h 03m1 stop
$240Multiple Airlines
Find Deal
Sun, Dec 14 - Wed, Dec 17
American Airlines Logo
9:30 am - 3:32 pmSTL-TYS
5h 02m1 stop
American Airlines Logo
1:14 pm - 4:50 pmTYS-STL
4h 36m1 stop
$251American Airlines
Find Deal
Sat, Dec 13 - Tue, Dec 16
Delta Logo
2:38 pm - 8:00 pmSTL-TYS
4h 22m1 stop
Delta Logo
5:40 am - 8:24 amTYS-STL
3h 44m1 stop
$265Delta
Find Deal
Tue, Dec 16 - Fri, Dec 19
Multiple Airlines Logo
9:54 am - 9:49 pmSTL-TYS
10h 55m1 stop
Multiple Airlines Logo
4:52 pm - 10:14 amTYS-STL
18h 22m1 stop
$272Multiple Airlines
Find Deal
Fri, Dec 5 - Sun, Dec 7
Delta Logo
7:05 am - 1:44 pmSTL-TYS
5h 39m1 stop
Delta Logo
6:05 pm - 9:58 pmTYS-STL
4h 53m1 stop
$279Delta
Find Deal
Thu, Nov 27 - Thu, Nov 27
United Airlines Logo
5:24 pm - 10:55 pmSTL-TYS
4h 31m1 stop
United Airlines Logo
10:50 am - 3:40 pmTYS-STL
5h 50m1 stop
$291United Airlines
Find Deal
Mon, Dec 1 - Thu, Dec 4
American Airlines Logo
5:15 am - 2:27 pmSTL-TYS
8h 12m1 stop
American Airlines Logo
5:24 am - 10:37 amTYS-STL
6h 13m1 stop
$307American Airlines
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Thu, Dec 4 - Sun, Dec 7
United Airlines Logo
6:30 am - 1:17 pmSTL-TYS
5h 47m1 stop
United Airlines Logo
6:45 am - 10:51 amTYS-STL
5h 06m1 stop
$364United Airlines
Find Deal
Wed, Nov 19 - Thu, Nov 20

United Airlines flights from St. Louis to Knoxville

Our best United Airlines deals on St. Louis to Knoxville flight tickets
United Airlines
Dec 1
STL5:24 pmLambert-St Louis
4h 31m
1 stop
TYS10:55 pmKnoxville McGhee Tyson
Dec 4
TYS10:50 amKnoxville McGhee Tyson
5h 50m
1 stop
STL3:40 pmLambert-St Louis
$291
Find similar
United Airlines
Nov 19
STL6:30 amLambert-St Louis
5h 47m
1 stop
TYS1:17 pmKnoxville McGhee Tyson
Nov 20
TYS6:45 amKnoxville McGhee Tyson
5h 06m
1 stop
STL10:51 amLambert-St Louis
$364
Find similar
United Airlines
Dec 13
STL4:37 pmLambert-St Louis
17h 11m
2 stops
TYS10:48 amKnoxville McGhee Tyson
Dec 16
TYS7:00 amKnoxville McGhee Tyson
6h 15m
1 stop
STL12:15 pmLambert-St Louis
$423
Find similar

Frontier flights from St. Louis to Knoxville

Our best Frontier deals on St. Louis to Knoxville flight tickets
Frontier
Nov 12
STL7:45 pmLambert-St Louis
21h 37m
1 stop
TYS6:22 pmKnoxville McGhee Tyson
Nov 16
TYS7:07 pmKnoxville McGhee Tyson
15h 00m
1 stop
STL9:07 amLambert-St Louis
$198
Find similar
Frontier
Nov 27
STL7:57 pmLambert-St Louis
18h 56m
1 stop
TYS3:53 pmKnoxville McGhee Tyson
Dec 4
TYS4:52 pmKnoxville McGhee Tyson
18h 22m
1 stop
STL10:14 amLambert-St Louis
$239
Find similar
Frontier
Nov 27
STL7:57 pmLambert-St Louis
18h 56m
1 stop
TYS3:53 pmKnoxville McGhee Tyson
Dec 4
TYS4:52 pmKnoxville McGhee Tyson
18h 22m
1 stop
STL10:14 amLambert-St Louis
$242
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 11/12

7:45 pm-6:22 pm

1 stop21h 37m

Knoxville McGhee Tyson

Sun 11/16

7:07 pm-9:07 am

1 stop15h 00m

$198

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 11/27

7:57 pm-3:53 pm

1 stop18h 56m

Knoxville McGhee Tyson

Thu 12/4

4:52 pm-10:14 am

1 stop18h 22m

$239

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 12/14

2:47 pm-8:33 am

1 stop16h 46m

Knoxville McGhee Tyson

Wed 12/17

2:53 pm-10:56 am

1 stop21h 03m

$240

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 12/13

9:30 am-3:32 pm

1 stop5h 02m

Knoxville McGhee Tyson

Tue 12/16

1:14 pm-4:50 pm

1 stop4h 36m

$251

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 12/16

2:38 pm-8:00 pm

1 stop4h 22m

Knoxville McGhee Tyson

Fri 12/19

5:40 am-8:24 am

1 stop3h 44m

$265

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 12/5

9:54 am-9:49 pm

1 stop10h 55m

Knoxville McGhee Tyson

Sun 12/7

4:52 pm-10:14 am

1 stop18h 22m

$272

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 11/27

7:05 am-1:44 pm

1 stop5h 39m

Knoxville McGhee Tyson

Thu 11/27

6:05 pm-9:58 pm

1 stop4h 53m

$279

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 12/1

5:24 pm-10:55 pm

1 stop4h 31m

Knoxville McGhee Tyson

Thu 12/4

10:50 am-3:40 pm

1 stop5h 50m

$291

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 12/4

5:15 am-2:27 pm

1 stop8h 12m

Knoxville McGhee Tyson

Sun 12/7

5:24 am-10:37 am

1 stop6h 13m

$307

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 11/19

6:30 am-1:17 pm

1 stop5h 47m

Knoxville McGhee Tyson

Thu 11/20

6:45 am-10:51 am

1 stop5h 06m

$364

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from St. Louis to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from St. Louis, with most prices found around $266. If you aren’t able to travel during the month of July, then book flights to Knoxville from St. Louis during April instead. Flights to Knoxville in April, while not as cheap as those in July, still average around $273.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from St. Louis to Knoxville is on a Thursday. Travelers who choose to depart for Knoxville on a Thursday will often find tickets for as low as $274. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from St. Louis to Knoxville for around $518.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from St. Louis to Knoxville when you can find flight prices for as low as $280. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $388.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $329 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from St. Louis for as low as $246 on momondo.

How have St. Louis to Knoxville flight prices changed over time?

As of October 2025, prices for St. Louis to Knoxville flights are approximately 20% cheaper when compared to flights at the same time last year.

When to book flights from St. Louis to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Knoxville (STL to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Knoxville

Direct flights

None
There are no direct flights from St. Louis to Knoxville. There are no popular flight routes from St. Louis to Knoxville.
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  • How far is Lambert-St Louis to Knoxville McGhee Tyson by plane?

    Lambert-St Louis and Knoxville McGhee Tyson are 390.7 mi apart from one another. Flights usually cover this in 3h 57m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Knoxville?

Best airlines flying from St. Louis to Knoxville

Compare and see reviews for airlines that fly from St. Louis to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $213Free CancellationRating
7.4
8,998 reviews
Search United Airlines flights
American AirlinesPriceFrom $218Free CancellationRating
7.2
11,035 reviews
Search American Airlines flights
DeltaPriceFrom $228Free CancellationRating
7.9
7,998 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from St. Louis to Knoxville?

momondo helps you find the best flight between St. Louis and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from St. Louis to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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