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Cheap flights from St. Louis to Knoxville from $111

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Knoxville departing on 6/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from St. Louis to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:52 pm - 3:30 pm
STL
-
TYS
21h 38m
2 stops
Multiple Airlines Logo
3:53 pm - 11:59 pm
TYS
-
STL
9h 06m
1 stop
$244Multiple Airlines
Mon, Jul 13 - Thu, Jul 16
Multiple Airlines Logo
4:09 pm - 3:30 pm
STL
-
TYS
22h 21m
1 stop
Multiple Airlines Logo
3:53 pm - 11:59 pm
TYS
-
STL
9h 06m
1 stop
$253Multiple Airlines
Mon, Jul 13 - Thu, Jul 16
Multiple Airlines Logo
4:17 pm - 11:34 pm
STL
-
TYS
6h 17m
1 stop
Multiple Airlines Logo
12:40 pm - 5:30 pm
TYS
-
STL
29h 50m
2 stops
$256Multiple Airlines
Mon, Jun 15 - Mon, Jun 22
Multiple Airlines Logo
4:19 pm - 11:37 pm
STL
-
TYS
6h 18m
1 stop
Multiple Airlines Logo
5:05 pm - 8:55 am
TYS
-
STL
16h 50m
2 stops
$257Multiple Airlines
Fri, May 29 - Tue, Jun 2
Multiple Airlines Logo
4:19 pm - 11:37 pm
STL
-
TYS
6h 18m
1 stop
Multiple Airlines Logo
1:02 pm - 5:33 pm
TYS
-
STL
29h 31m
2 stops
$268Multiple Airlines
Mon, Jun 1 - Wed, Jun 3
Southwest Logo
5:50 am - 2:05 pm
STL
-
TYS
7h 15m
1 stop
Southwest Logo
6:55 pm - 11:00 pm
TYS
-
STL
5h 05m
1 stop
$269Southwest
Tue, Jun 16 - Tue, Jun 23
Multiple Airlines Logo
4:17 pm - 10:29 pm
STL
-
TYS
29h 12m
1 stop
Multiple Airlines Logo
8:00 am - 5:30 pm
TYS
-
STL
34h 30m
2 stops
$271Multiple Airlines
Wed, Jun 10 - Wed, Jun 17
Southwest Logo
1:20 pm - 9:15 pm
STL
-
TYS
6h 55m
1 stop
Southwest Logo
7:10 am - 1:05 pm
TYS
-
STL
6h 55m
2 stops
$274Southwest
Tue, Jun 9 - Tue, Jun 16
Multiple Airlines Logo
4:19 pm - 9:13 pm
STL
-
TYS
27h 54m
1 stop
Multiple Airlines Logo
12:40 pm - 5:30 pm
TYS
-
STL
29h 50m
2 stops
$276Multiple Airlines
Sun, May 31 - Mon, Jun 8
American Airlines Logo
7:01 am - 1:02 pm
STL
-
TYS
5h 01m
1 stop
American Airlines Logo
7:59 pm - 11:44 pm
TYS
-
STL
4h 45m
1 stop
$279American Airlines
Sat, Jun 6 - Wed, Jun 10

American Airlines flights from St. Louis to Knoxville

Our best American Airlines deals on St. Louis to Knoxville flight tickets
American Airlines
Jun 24
STL11:18 amLambert-St Louis
6h 20m
1 stop
TYS6:38 pmKnoxville McGhee Tyson
Jun 28
TYS6:12 amKnoxville McGhee Tyson
5h 25m
1 stop
STL10:37 amLambert-St Louis
$284
American Airlines
Jun 26
STL5:18 pmLambert-St Louis
5h 37m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
Jun 28
TYS5:00 amKnoxville McGhee Tyson
4h 32m
1 stop
STL8:32 amLambert-St Louis
$299
American Airlines
Jun 6
STL7:01 amLambert-St Louis
5h 01m
1 stop
TYS1:02 pmKnoxville McGhee Tyson
Jun 10
TYS7:03 pmKnoxville McGhee Tyson
5h 56m
1 stop
STL11:59 pmLambert-St Louis
$323

Southwest flights from St. Louis to Knoxville

Our best Southwest deals on St. Louis to Knoxville flight tickets
Southwest
Jun 16
STL5:50 amLambert-St Louis
7h 15m
1 stop
TYS2:05 pmKnoxville McGhee Tyson
Jun 23
TYS6:55 pmKnoxville McGhee Tyson
5h 05m
1 stop
STL11:00 pmLambert-St Louis
$269
Southwest
Jun 9
STL1:20 pmLambert-St Louis
6h 55m
1 stop
TYS9:15 pmKnoxville McGhee Tyson
Jun 16
TYS7:10 amKnoxville McGhee Tyson
6h 55m
2 stops
STL1:05 pmLambert-St Louis
$274
Southwest
Jun 9
STL11:20 amLambert-St Louis
8h 00m
2 stops
TYS8:20 pmKnoxville McGhee Tyson
Jun 16
TYS7:10 amKnoxville McGhee Tyson
6h 55m
2 stops
STL1:05 pmLambert-St Louis
$280

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 17, 2026.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 7/13

4:52 pm-3:30 pm

2 stops21h 38m

Knoxville McGhee Tyson

Thu 7/16

3:53 pm-11:59 pm

1 stop9h 06m

$244

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 7/13

4:09 pm-3:30 pm

1 stop22h 21m

Knoxville McGhee Tyson

Thu 7/16

3:53 pm-11:59 pm

1 stop9h 06m

$253

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 6/15

4:17 pm-11:34 pm

1 stop6h 17m

Knoxville McGhee Tyson

Mon 6/22

12:40 pm-5:30 pm

2 stops29h 50m

$256

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 5/29

4:19 pm-11:37 pm

1 stop6h 18m

Knoxville McGhee Tyson

Tue 6/2

5:05 pm-8:55 am

2 stops16h 50m

$257

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 6/1

4:19 pm-11:37 pm

1 stop6h 18m

Knoxville McGhee Tyson

Wed 6/3

1:02 pm-5:33 pm

2 stops29h 31m

$268

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 6/16

5:50 am-2:05 pm

1 stop7h 15m

Knoxville McGhee Tyson

Tue 6/23

6:55 pm-11:00 pm

1 stop5h 05m

$269

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 6/10

4:17 pm-10:29 pm

1 stop29h 12m

Knoxville McGhee Tyson

Wed 6/17

8:00 am-5:30 pm

2 stops34h 30m

$271

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 6/9

1:20 pm-9:15 pm

1 stop6h 55m

Knoxville McGhee Tyson

Tue 6/16

7:10 am-1:05 pm

2 stops6h 55m

$274

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 5/31

4:19 pm-9:13 pm

1 stop27h 54m

Knoxville McGhee Tyson

Mon 6/8

12:40 pm-5:30 pm

2 stops29h 50m

$276
Quickest round-trip

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 6/6

7:01 am-1:02 pm

1 stop5h 01m

Knoxville McGhee Tyson

Wed 6/10

7:59 pm-11:44 pm

1 stop4h 45m

$279

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from St. Louis to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from St. Louis, with most prices found around $277. If you aren’t able to travel during the month of August, then book flights to Knoxville from St. Louis during July instead. Flights to Knoxville in July, while not as cheap as those in August, still average around $283.

How have St. Louis to Knoxville flight prices changed over time?

As of May 2026, prices for St. Louis to Knoxville flights are approximately 73% cheaper when compared to flights at the same time last year.

When to book flights from St. Louis to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Knoxville (STL to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Knoxville

Fastest flight time

2h 35m

Direct flights

None
The fastest flight from St. Louis to Knoxville takes 2h 35m
There are no direct flights from St. Louis to Knoxville. There are no popular flight routes from St. Louis to Knoxville.
Search flight deals

Frequently asked questions about flying from St. Louis to Knoxville

  • How far is Lambert-St Louis to Knoxville McGhee Tyson by plane?

    Lambert-St Louis and Knoxville McGhee Tyson are 390.7 mi apart from one another. Flights usually cover this in 2h 35m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Knoxville?

Best airlines flying from St. Louis to Knoxville

Compare and see reviews for airlines that fly from St. Louis to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $213Free CancellationRating
7.1
11,654 reviews
Search American Airlines flights
DeltaPriceFrom $228Free CancellationRating
7.9
8,451 reviews
Search Delta flights
SouthwestPriceFrom $248Free CancellationRating
8.0
4,291 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from St. Louis to Knoxville?

momondo helps you find the best flight between St. Louis and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from St. Louis to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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