Cheap flights from St. Louis to Knoxville from $100
This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Knoxville departing on 7/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
Discover deals from 900+ travel sites with momondo.
Save money when you book flights with momondo
Big names and deals
Big names and deals
Search 100s of travel sites to compare prices.Filter for what you want
Filter for what you want
Free Wi-Fi? Stopover? Instantly customize your results.Trusted and free
Trusted and free
We’re completely free to use - no hidden charges or fees.Price Alerts
Price Alerts
Not ready to book? to track prices.Find the cheapest flights from St. Louis to Knoxville
Cheap round-trip flights
Cheap one-way flights
Cheap last minute flights
Delta flights from St. Louis to Knoxville
Our best Delta deals on St. Louis to Knoxville flight tickets
American Airlines flights from St. Louis to Knoxville
Our best American Airlines deals on St. Louis to Knoxville flight tickets
See travel insights to Knoxville from
How to get the cheapest flight ticket from St. Louis to Knoxville
Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip
What is the cheapest month to fly to Knoxville?
The month of July is, on average, the cheapest month to fly to Knoxville from St. Louis, with most prices found around $245. If you aren’t able to travel during the month of July, then book flights to Knoxville from St. Louis during November instead. Flights to Knoxville in November, while not as cheap as those in July, still average around $260.
What is the cheapest day to depart on your flight to Knoxville?
The cheapest day to depart from St. Louis to Knoxville is on a Thursday. Travelers who choose to depart for Knoxville on a Thursday will often find tickets for as low as $274. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from St. Louis to Knoxville for around $518.
What is the cheapest time of day to depart on your flight to Knoxville?
In the evening is the cheapest time of day to fly from St. Louis to Knoxville when you can find flight prices for as low as $280. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $388.
How far in advance should I book a flight to Knoxville?
You are more likely to see cheaper flights to Knoxville from St. Louis when booking 16 weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $340 when searching 16 weeks out.However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from St. Louis for as low as $226 on momondo.
What is the cheapest airline that flies from Lambert-St Louis to Knoxville McGhee Tyson?
Delta, American Airlines, and Frontier are the most popular carriers operating from Lambert-St Louis to Knoxville McGhee Tyson
What airlines fly to Knoxville?
American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Knoxville from St. Louis according to our data. American Airlines is the first choice among our users, with 58% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 4 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.
When to book flights from St. Louis to Knoxville
Cheap St. Louis to Knoxville (STL to TYS) flight deals and tips
Find info about flight duration, direct flights, and airports for your flight from St. Louis to Knoxville
How far is Lambert-St Louis to Knoxville McGhee Tyson by plane?
Lambert-St Louis and Knoxville McGhee Tyson are 390.7 mi apart from one another. Flights usually cover this in 4h 03m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport were last updated today.
How many operators does momondo search for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?
The number of operators available for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport is 3 as of June 2025.
How old do you have to be to fly from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular airline from St. Louis to Knoxville?
Based on momondo bookings for this flight route, the most popular airline on flight routes from St. Louis to Knoxville is American Airlines (58% of total bookings). The next most popular airlines are Delta (34%) and United Airlines (7%).
Best airlines flying from St. Louis to Knoxville
Compare and see reviews for airlines that fly from St. Louis to Knoxville with momondo
| Airline | Rating | Free Cancellation | Price | ||
|---|---|---|---|---|---|
| PriceFrom $213 | Free Cancellation | Rating 7.4 8,790 reviews | |||
| PriceFrom $213 | Free Cancellation | Rating 7.2 10,000 reviews | |||
| PriceFrom $222 | Free Cancellation | Rating 8.0 7,950 reviews |
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsWhy use momondo?
Why should I use momondo to find a flight deal from St. Louis to Knoxville?
momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Knoxville. Millions of users trust and use momondo every year so you are in good hands.
Can I find flights from St. Louis to Knoxville with flexible booking policies on momondo?
Yes. All flights to Knoxville from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.
How can momondo help me find flights from St. Louis to Knoxville?
momondo helps you find the best flight between St. Louis and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.
I’m not ready to book a flight from St. Louis to Knoxville right now. Can momondo alert me if prices change?
If you are not ready to book a flight from St. Louis to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.