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Cheap flights from St. Louis to Knoxville from $117

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Knoxville departing on 4/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from St. Louis to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
3:49 pm - 6:26 pm
STL
-
TYS
25h 37m
1 stop
Multiple Airlines Logo
10:00 am - 11:19 pm
TYS
-
STL
14h 19m
1 stop
$197Multiple Airlines
Tue, Mar 3 - Tue, Mar 10
Multiple Airlines Logo
3:49 pm - 6:26 pm
STL
-
TYS
25h 37m
1 stop
Multiple Airlines Logo
11:00 am - 10:37 am
TYS
-
STL
24h 37m
2 stops
$214Multiple Airlines
Tue, Mar 3 - Tue, Mar 10
Delta Logo
7:10 am - 1:51 pm
STL
-
TYS
5h 41m
1 stop
Delta Logo
5:40 am - 11:09 am
TYS
-
STL
6h 29m
1 stop
$251Delta
Wed, Mar 4 - Wed, Mar 11
Southwest Logo
7:30 am - 11:50 am
STL
-
TYS
3h 20m
1 stop
Southwest Logo
7:25 pm - 12:15 am
TYS
-
STL
5h 50m
1 stop
$256Southwest
Wed, Mar 11 - Sun, Mar 15
Southwest Logo
1:15 pm - 8:50 pm
STL
-
TYS
6h 35m
1 stop
Southwest Logo
6:35 am - 1:15 pm
TYS
-
STL
7h 40m
1 stop
$261Southwest
Tue, Apr 7 - Fri, Apr 10
Southwest Logo
10:15 am - 7:40 pm
STL
-
TYS
8h 25m
2 stops
Southwest Logo
6:35 am - 12:50 pm
TYS
-
STL
7h 15m
2 stops
$266Southwest
Tue, Apr 7 - Fri, Apr 10
Multiple Airlines Logo
8:17 pm - 8:57 pm
STL
-
TYS
23h 40m
2 stops
Multiple Airlines Logo
8:30 am - 11:19 pm
TYS
-
STL
15h 49m
1 stop
$267Multiple Airlines
Wed, Mar 4 - Wed, Mar 11
Southwest Logo
2:25 pm - 8:05 pm
STL
-
TYS
4h 40m
1 stop
Southwest Logo
6:35 am - 1:55 pm
TYS
-
STL
8h 20m
2 stops
$273Southwest
Wed, Mar 25 - Sat, Mar 28
American Airlines Logo
6:11 pm - 11:56 pm
STL
-
TYS
4h 45m
1 stop
American Airlines Logo
7:00 am - 12:48 pm
TYS
-
STL
6h 48m
1 stop
$278American Airlines
Mon, Apr 13 - Sun, Apr 19
Southwest Logo
4:55 pm - 9:15 pm
STL
-
TYS
3h 20m
1 stop
Southwest Logo
3:45 pm - 10:10 pm
TYS
-
STL
7h 25m
1 stop
$279Southwest
Mon, Mar 16 - Mon, Mar 23

Delta flights from St. Louis to Knoxville

Our best Delta deals on St. Louis to Knoxville flight tickets
Delta
Mar 4
STL6:00 amLambert-St Louis
4h 08m
1 stop
TYS11:08 amKnoxville McGhee Tyson
Mar 25
TYS5:40 amKnoxville McGhee Tyson
4h 25m
1 stop
STL9:05 amLambert-St Louis
$251
Delta
Mar 4
STL6:00 amLambert-St Louis
4h 08m
1 stop
TYS11:08 amKnoxville McGhee Tyson
Mar 11
TYS5:40 amKnoxville McGhee Tyson
6h 29m
1 stop
STL11:09 amLambert-St Louis
$313
Delta
Feb 24
STL7:10 amLambert-St Louis
5h 41m
1 stop
TYS1:51 pmKnoxville McGhee Tyson
Feb 28
TYS5:35 amKnoxville McGhee Tyson
6h 27m
1 stop
STL11:02 amLambert-St Louis
$329

Southwest flights from St. Louis to Knoxville

Our best Southwest deals on St. Louis to Knoxville flight tickets
Southwest
Apr 7
STL2:30 pmLambert-St Louis
4h 10m
1 stop
TYS7:40 pmKnoxville McGhee Tyson
Apr 10
TYS6:35 amKnoxville McGhee Tyson
6h 55m
2 stops
STL12:30 pmLambert-St Louis
$261
Southwest
Apr 7
STL10:15 amLambert-St Louis
8h 25m
2 stops
TYS7:40 pmKnoxville McGhee Tyson
Apr 10
TYS6:35 amKnoxville McGhee Tyson
7h 15m
2 stops
STL12:50 pmLambert-St Louis
$266
Southwest
Mar 25
STL2:25 pmLambert-St Louis
4h 40m
1 stop
TYS8:05 pmKnoxville McGhee Tyson
Mar 28
TYS6:35 amKnoxville McGhee Tyson
8h 20m
2 stops
STL1:55 pmLambert-St Louis
$273

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 8, 2026.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 3/3

3:49 pm-6:26 pm

1 stop25h 37m

Knoxville McGhee Tyson

Tue 3/10

10:00 am-11:19 pm

1 stop14h 19m

$197

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 3/3

3:49 pm-6:26 pm

1 stop25h 37m

Knoxville McGhee Tyson

Tue 3/10

11:00 am-10:37 am

2 stops24h 37m

$214

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 3/4

7:10 am-1:51 pm

1 stop5h 41m

Knoxville McGhee Tyson

Wed 3/11

5:40 am-11:09 am

1 stop6h 29m

$251

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 3/11

7:30 am-11:50 am

1 stop3h 20m

Knoxville McGhee Tyson

Sun 3/15

7:25 pm-12:15 am

1 stop5h 50m

$256

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 4/7

1:15 pm-8:50 pm

1 stop6h 35m

Knoxville McGhee Tyson

Fri 4/10

6:35 am-1:15 pm

1 stop7h 40m

$261

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 4/7

10:15 am-7:40 pm

2 stops8h 25m

Knoxville McGhee Tyson

Fri 4/10

6:35 am-12:50 pm

2 stops7h 15m

$266

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 3/4

8:17 pm-8:57 pm

2 stops23h 40m

Knoxville McGhee Tyson

Wed 3/11

8:30 am-11:19 pm

1 stop15h 49m

$267

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 3/25

2:25 pm-8:05 pm

1 stop4h 40m

Knoxville McGhee Tyson

Sat 3/28

6:35 am-1:55 pm

2 stops8h 20m

$273

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 4/13

6:11 pm-11:56 pm

1 stop4h 45m

Knoxville McGhee Tyson

Sun 4/19

7:00 am-12:48 pm

1 stop6h 48m

$278

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 3/16

4:55 pm-9:15 pm

1 stop3h 20m

Knoxville McGhee Tyson

Mon 3/23

3:45 pm-10:10 pm

1 stop7h 25m

$279

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from St. Louis to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from St. Louis, with most prices found around $266. If you aren’t able to travel during the month of July, then book flights to Knoxville from St. Louis during August instead. Flights to Knoxville in August, while not as cheap as those in July, still average around $277.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $329 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from St. Louis for as low as $257 on momondo.

How have St. Louis to Knoxville flight prices changed over time?

As of February 2026, prices for St. Louis to Knoxville flights are approximately 41% cheaper when compared to flights at the same time last year.

When to book flights from St. Louis to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Knoxville (STL to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Knoxville

Fastest flight time

3h 20m

Direct flights

None
The fastest flight from St. Louis to Knoxville takes 3h 20m
There are no direct flights from St. Louis to Knoxville. There are no popular flight routes from St. Louis to Knoxville.
Search flight deals

  • How far is Lambert-St Louis to Knoxville McGhee Tyson by plane?

    Lambert-St Louis and Knoxville McGhee Tyson are 390.7 mi apart from one another. Flights usually cover this in 3h 20m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Knoxville?

Best airlines flying from St. Louis to Knoxville

Compare and see reviews for airlines that fly from St. Louis to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $213Free CancellationRating
7.4
9,257 reviews
Search United Airlines flights
American AirlinesPriceFrom $213Free CancellationRating
7.2
11,255 reviews
Search American Airlines flights
DeltaPriceFrom $222Free CancellationRating
7.9
8,173 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from St. Louis to Knoxville?

momondo helps you find the best flight between St. Louis and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from St. Louis to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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