Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from St. Louis to Knoxville from $116

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Knoxville departing on 10/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from St. Louis to Knoxville

Cheap round-trip flights

Frontier Logo
10:17 am - 7:32 pmSTL-TYS
32h 15m2 stops
Frontier Logo
7:17 pm - 9:07 amTYS-STL
14h 50m1 stop
$212Frontier
Find Deal
Sun, Oct 26 - Thu, Oct 30
Multiple Airlines Logo
10:57 am - 8:25 pmSTL-TYS
8h 28m1 stop
Multiple Airlines Logo
7:17 pm - 9:07 amTYS-STL
14h 50m1 stop
$230Multiple Airlines
Find Deal
Sun, Oct 26 - Thu, Oct 30
Delta Logo
10:00 am - 3:06 pmSTL-TYS
4h 06m1 stop
Delta Logo
10:05 am - 3:01 pmTYS-STL
5h 56m1 stop
$237Delta
Find Deal
Wed, Feb 18 - Sat, Feb 21
Multiple Airlines Logo
12:20 pm - 10:33 pmSTL-TYS
9h 13m1 stop
Multiple Airlines Logo
1:16 pm - 9:07 amTYS-STL
20h 51m2 stops
$246Multiple Airlines
Find Deal
Thu, Nov 6 - Sun, Nov 9
Delta Logo
9:30 am - 2:51 pmSTL-TYS
4h 21m1 stop
Delta Logo
6:10 pm - 11:40 pmTYS-STL
6h 30m1 stop
$249Delta
Find Deal
Tue, Dec 16 - Tue, Jan 6
American Airlines Logo
5:58 pm - 12:08 amSTL-TYS
5h 10m1 stop
American Airlines Logo
12:08 pm - 5:28 pmTYS-STL
6h 20m1 stop
$265American Airlines
Find Deal
Mon, Nov 10 - Wed, Nov 12
American Airlines Logo
7:16 am - 2:33 pmSTL-TYS
6h 17m1 stop
American Airlines Logo
8:37 pm - 11:58 pmTYS-STL
4h 21m1 stop
$289American Airlines
Find Deal
Mon, Oct 13 - Mon, Oct 20
American Airlines Logo
7:00 am - 1:24 pmSTL-TYS
5h 24m1 stop
American Airlines Logo
7:43 pm - 11:05 pmTYS-STL
4h 22m1 stop
$294American Airlines
Find Deal
Wed, Oct 8 - Wed, Oct 15
United Airlines Logo
8:30 am - 2:43 pmSTL-TYS
5h 13m1 stop
United Airlines Logo
6:45 am - 12:29 pmTYS-STL
6h 44m1 stop
$311United Airlines
Find Deal
Tue, Dec 16 - Tue, Jan 6
United Airlines Logo
4:35 pm - 11:44 pmSTL-TYS
6h 09m1 stop
United Airlines Logo
7:20 pm - 3:46 pmTYS-STL
21h 26m2 stops
$453United Airlines
Find Deal
Tue, Nov 11 - Fri, Nov 14

American Airlines flights from St. Louis to Knoxville

Our best American Airlines deals on St. Louis to Knoxville flight tickets
American Airlines
Nov 10
STL5:58 pmLambert-St Louis
5h 10m
1 stop
TYS12:08 amKnoxville McGhee Tyson
Nov 12
TYS12:08 pmKnoxville McGhee Tyson
6h 20m
1 stop
STL5:28 pmLambert-St Louis
$265
Find similar
American Airlines
Oct 13
STL7:16 amLambert-St Louis
6h 17m
1 stop
TYS2:33 pmKnoxville McGhee Tyson
Oct 20
TYS8:37 pmKnoxville McGhee Tyson
4h 21m
1 stop
STL11:58 pmLambert-St Louis
$289
Find similar
American Airlines
Oct 8
STL7:00 amLambert-St Louis
5h 24m
1 stop
TYS1:24 pmKnoxville McGhee Tyson
Oct 15
TYS7:43 pmKnoxville McGhee Tyson
4h 22m
1 stop
STL11:05 pmLambert-St Louis
$294
Find similar

Delta flights from St. Louis to Knoxville

Our best Delta deals on St. Louis to Knoxville flight tickets
Delta
Feb 18
STL10:00 amLambert-St Louis
4h 06m
1 stop
TYS3:06 pmKnoxville McGhee Tyson
Feb 21
TYS10:05 amKnoxville McGhee Tyson
5h 56m
1 stop
STL3:01 pmLambert-St Louis
$237
Find similar
Delta
Dec 16
STL9:30 amLambert-St Louis
4h 21m
1 stop
TYS2:51 pmKnoxville McGhee Tyson
Jan 6
TYS6:10 pmKnoxville McGhee Tyson
6h 30m
1 stop
STL11:40 pmLambert-St Louis
$249
Find similar
Delta
Sep 25
STL6:01 amLambert-St Louis
3h 41m
1 stop
TYS10:42 amKnoxville McGhee Tyson
Sep 29
TYS6:08 pmKnoxville McGhee Tyson
6h 16m
1 stop
STL11:24 pmLambert-St Louis
$274
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 10/26

10:17 am-7:32 pm

2 stops32h 15m

Knoxville McGhee Tyson

Thu 10/30

7:17 pm-9:07 am

1 stop14h 50m

$212

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 10/26

10:57 am-8:25 pm

1 stop8h 28m

Knoxville McGhee Tyson

Thu 10/30

7:17 pm-9:07 am

1 stop14h 50m

$230

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 2/18

10:00 am-3:06 pm

1 stop4h 06m

Knoxville McGhee Tyson

Sat 2/21

10:05 am-3:01 pm

1 stop5h 56m

$237

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 11/6

12:20 pm-10:33 pm

1 stop9h 13m

Knoxville McGhee Tyson

Sun 11/9

1:16 pm-9:07 am

2 stops20h 51m

$246

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 12/16

9:30 am-2:51 pm

1 stop4h 21m

Knoxville McGhee Tyson

Tue 1/6

6:10 pm-11:40 pm

1 stop6h 30m

$249

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 11/10

5:58 pm-12:08 am

1 stop5h 10m

Knoxville McGhee Tyson

Wed 11/12

12:08 pm-5:28 pm

1 stop6h 20m

$265

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 10/13

7:16 am-2:33 pm

1 stop6h 17m

Knoxville McGhee Tyson

Mon 10/20

8:37 pm-11:58 pm

1 stop4h 21m

$289

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 10/8

7:00 am-1:24 pm

1 stop5h 24m

Knoxville McGhee Tyson

Wed 10/15

7:43 pm-11:05 pm

1 stop4h 22m

$294

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 12/16

8:30 am-2:43 pm

1 stop5h 13m

Knoxville McGhee Tyson

Tue 1/6

6:45 am-12:29 pm

1 stop6h 44m

$311

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 11/11

4:35 pm-11:44 pm

1 stop6h 09m

Knoxville McGhee Tyson

Fri 11/14

7:20 pm-3:46 pm

2 stops21h 26m

$453

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Knoxville from

How to get the cheapest flight ticket from St. Louis to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from St. Louis, with most prices found around $258. If you aren’t able to travel during the month of July, then book flights to Knoxville from St. Louis during April instead. Flights to Knoxville in April, while not as cheap as those in July, still average around $273.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from St. Louis to Knoxville is on a Thursday. Travelers who choose to depart for Knoxville on a Thursday will often find tickets for as low as $274. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from St. Louis to Knoxville for around $518.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from St. Louis to Knoxville when you can find flight prices for as low as $280. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $388.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $335 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from St. Louis for as low as $171 on momondo.

How have St. Louis to Knoxville flight prices changed over time?

As of September 2025, prices for St. Louis to Knoxville flights are approximately 89% more expensive when compared to flights at the same time last year.

When to book flights from St. Louis to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Knoxville (STL to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Knoxville

Direct flights

None
There are no direct flights from St. Louis to Knoxville. There are no popular flight routes from St. Louis to Knoxville.
Search flight deals

  • How far is Lambert-St Louis to Knoxville McGhee Tyson by plane?

    Lambert-St Louis and Knoxville McGhee Tyson are 390.7 mi apart from one another. Flights usually cover this in 3h 45m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Knoxville?

Best airlines flying from St. Louis to Knoxville

Compare and see reviews for airlines that fly from St. Louis to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $213Free CancellationRating
7.4
8,924 reviews
Search United Airlines flights
American AirlinesPriceFrom $213Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $222Free CancellationRating
7.9
7,957 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Newport
Lenoir City
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from St. Louis to Knoxville?

momondo helps you find the best flight between St. Louis and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from St. Louis to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 10/16
Thu 10/23
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States