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Cheap flights from St. Louis to Knoxville from $94

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Knoxville departing on 11/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from St. Louis to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
11:01 am - 4:11 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
4h 10m1 stop Chicago O'Hare Intl
American Airlines Logo
8:18 am - 1:03 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
5h 45m1 stop Charlotte Douglas
$205American Airlines
Sat, Sep 12 - Wed, Sep 16
American Airlines Logo
5:00 am - 12:30 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
6h 30m1 stop Chicago O'Hare Intl
American Airlines Logo
8:15 pm - 12:27 amTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
5h 12m1 stop Chicago O'Hare Intl
$205American Airlines
Sat, Sep 12 - Wed, Sep 16
Southwest Logo
7:05 am - 2:20 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
6h 15m1 stop Dallas Love Field
Southwest Logo
4:20 pm - 11:10 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
7h 50m1 stop Denver Intl
$206Southwest
Tue, Sep 29 - Tue, Oct 6
Southwest Logo
6:50 am - 1:15 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
5h 25m1 stop Dallas Love Field
Southwest Logo
7:00 am - 2:50 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
8h 50m2 stops Nashville Intl Baltimore/Washington
$210Southwest
Sat, Sep 12 - Wed, Sep 16
Southwest Logo
1:40 pm - 7:55 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
5h 15m1 stop Baltimore/Washington
Southwest Logo
8:20 am - 2:55 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
7h 35m2 stops Baltimore/Washington Nashville Intl
$211Southwest
Tue, Sep 29 - Tue, Oct 6
American Airlines Logo
5:13 pm - 11:22 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
5h 09m1 stop Chicago O'Hare Intl
American Airlines Logo
6:52 pm - 12:14 amTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
6h 22m1 stop Chicago O'Hare Intl
$229American Airlines
Sat, Sep 5 - Tue, Sep 8
United Airlines Logo
10:53 am - 4:58 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
5h 05m1 stop Chicago O'Hare Intl
United Airlines Logo
6:00 am - 10:12 amTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
5h 12m1 stop Chicago O'Hare Intl
$260United Airlines
Sun, Sep 6 - Sun, Sep 13
Delta Logo
7:20 pm - 11:59 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
3h 39m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:24 pm - 11:54 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
5h 30m1 stop Atlanta Hartsfield-Jackson
$263Delta
Thu, Oct 15 - Mon, Oct 19
Delta Logo
7:00 am - 1:40 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
5h 40m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:23 pm - 11:54 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
6h 31m1 stop Atlanta Hartsfield-Jackson
$263Delta
Wed, Oct 7 - Wed, Oct 7
Multiple Airlines Logo
6:17 pm - 4:21 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
45h 04m2 stops Atlanta Hartsfield-Jackson Jacksonville
Multiple Airlines Logo
8:20 am - 4:34 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
9h 14m1 stop Orlando
$276Multiple Airlines
Fri, Sep 4 - Fri, Sep 11

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American Airlines flights from St. Louis to Knoxville

Our best American Airlines deals on St. Louis to Knoxville flight tickets
American Airlines
Sep 12
STL5:00 amLambert-St Louis
6h 30m
1 stop
TYS12:30 pmKnoxville McGhee Tyson
Sep 16
TYS8:15 pmKnoxville McGhee Tyson
5h 12m
1 stop
STL12:27 amLambert-St Louis
$205
American Airlines
Sep 5
STL5:13 pmLambert-St Louis
5h 09m
1 stop
TYS11:22 pmKnoxville McGhee Tyson
Sep 8
TYS6:52 pmKnoxville McGhee Tyson
6h 22m
1 stop
STL12:14 amLambert-St Louis
$229
American Airlines
Sep 12
STL7:27 amLambert-St Louis
4h 03m
1 stop
TYS12:30 pmKnoxville McGhee Tyson
Sep 17
TYS8:15 pmKnoxville McGhee Tyson
5h 12m
1 stop
STL12:27 amLambert-St Louis
$247

United Airlines flights from St. Louis to Knoxville

Our best United Airlines deals on St. Louis to Knoxville flight tickets
United Airlines
Sep 12
STL5:30 pmLambert-St Louis
4h 19m
1 stop
TYS10:49 pmKnoxville McGhee Tyson
Sep 17
TYS6:02 pmKnoxville McGhee Tyson
5h 57m
1 stop
STL10:59 pmLambert-St Louis
$303
United Airlines
Sep 28
STL3:11 pmLambert-St Louis
4h 38m
1 stop
TYS8:49 pmKnoxville McGhee Tyson
Oct 1
TYS6:00 amKnoxville McGhee Tyson
7h 13m
1 stop
STL12:13 pmLambert-St Louis
$317
United Airlines
Sep 12
STL12:28 pmLambert-St Louis
9h 21m
2 stops
TYS10:49 pmKnoxville McGhee Tyson
Sep 17
TYS6:00 amKnoxville McGhee Tyson
6h 57m
1 stop
STL11:57 amLambert-St Louis
$322

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Sat 9/12

11:01 am-4:11 pm

1 stop4h 10m

Knoxville McGhee Tyson

Wed 9/16

8:18 am-1:03 pm

1 stop5h 45m

$205

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Sat 9/12

5:00 am-12:30 pm

1 stop6h 30m

Knoxville McGhee Tyson

Wed 9/16

8:15 pm-12:27 am

1 stop5h 12m

$205

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Tue 9/29

7:05 am-2:20 pm

1 stop6h 15m

Knoxville McGhee Tyson

Tue 10/6

4:20 pm-11:10 pm

1 stop7h 50m

$206

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Sat 9/12

6:50 am-1:15 pm

1 stop5h 25m

Knoxville McGhee Tyson

Wed 9/16

7:00 am-2:50 pm

2 stops8h 50m

$210

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Tue 9/29

1:40 pm-7:55 pm

1 stop5h 15m

Knoxville McGhee Tyson

Tue 10/6

8:20 am-2:55 pm

2 stops7h 35m

$211

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Sat 9/5

5:13 pm-11:22 pm

1 stop5h 09m

Knoxville McGhee Tyson

Tue 9/8

6:52 pm-12:14 am

1 stop6h 22m

$229

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Sun 9/6

10:53 am-4:58 pm

1 stop5h 05m

Knoxville McGhee Tyson

Sun 9/13

6:00 am-10:12 am

1 stop5h 12m

$260
Quickest round-trip

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Thu 10/15

7:20 pm-11:59 pm

1 stop3h 39m

Knoxville McGhee Tyson

Mon 10/19

7:24 pm-11:54 pm

1 stop5h 30m

$263

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Wed 10/7

7:00 am-1:40 pm

1 stop5h 40m

Knoxville McGhee Tyson

Wed 10/7

6:23 pm-11:54 pm

1 stop6h 31m

$263

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Fri 9/4

6:17 pm-4:21 pm

2 stops45h 04m

Knoxville McGhee Tyson

Fri 9/11

8:20 am-4:34 pm

1 stop9h 14m

$276

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from St. Louis to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $252 to $328.
The lowest price recently found on this route was $205.

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from St. Louis, with most prices found around $278. If you aren’t able to travel during the month of August, then book flights to Knoxville from St. Louis during September instead. Flights to Knoxville in September, while not as cheap as those in August, still average around $317.

Can stopping save me money on St. Louis to Knoxville flights?

You could potentially save up to 2% on your flight if you consider stops on a St. Louis to Knoxville flight.

How have St. Louis to Knoxville flight prices changed over time?

As of August 2026, prices for St. Louis to Knoxville flights are approximately 85% more expensive when compared to flights at the same time last year.

When to book flights from St. Louis to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Knoxville (STL to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Knoxville

Fastest flight time

3h 18m

Direct flights

None
The fastest flight from St. Louis to Knoxville takes 3h 18m
There are no direct flights from St. Louis to Knoxville. There are no popular flight routes from St. Louis to Knoxville.
Search flight deals

Frequently asked questions about flying from St. Louis to Knoxville

  • How far is Lambert-St Louis to Knoxville McGhee Tyson by plane?

    Lambert-St Louis and Knoxville McGhee Tyson are 390.7 mi apart from one another. Flights usually cover this in 3h 18m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Knoxville?

Best airlines flying from St. Louis to Knoxville

Compare and see reviews for airlines that fly from St. Louis to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $217Free CancellationRating
7.8
8,500 reviews
Search Delta flights
American AirlinesPriceFrom $228Free CancellationRating
7.1
11,899 reviews
Search American Airlines flights
SouthwestPriceFrom $248Free CancellationRating
8.0
4,218 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from St. Louis to Knoxville?

momondo helps you find the best flight between St. Louis and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from St. Louis to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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