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Cheap flights from St. Louis to Knoxville from $136

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Knoxville departing on 4/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from St. Louis to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:06 pm - 5:30 pm
STL
-
TYS
20h 24m
2 stops
Multiple Airlines Logo
1:15 pm - 11:19 pm
TYS
-
STL
11h 04m
1 stop
$263Multiple Airlines
Thu, Apr 16 - Mon, Apr 20
American Airlines Logo
5:18 pm - 11:56 pm
STL
-
TYS
5h 38m
1 stop
American Airlines Logo
6:12 am - 10:37 am
TYS
-
STL
5h 25m
1 stop
$277American Airlines
Thu, May 28 - Tue, Jun 2
Multiple Airlines Logo
4:59 pm - 5:30 pm
STL
-
TYS
23h 31m
1 stop
Multiple Airlines Logo
1:15 pm - 11:19 pm
TYS
-
STL
11h 04m
1 stop
$283Multiple Airlines
Thu, Apr 16 - Mon, Apr 20
Delta Logo
5:00 pm - 11:54 pm
STL
-
TYS
5h 54m
1 stop
Delta Logo
5:40 am - 8:30 am
TYS
-
STL
3h 50m
1 stop
$285Delta
Sat, Apr 25 - Fri, May 1
Southwest Logo
8:25 am - 2:05 pm
STL
-
TYS
4h 40m
1 stop
Southwest Logo
12:50 pm - 5:15 pm
TYS
-
STL
5h 25m
1 stop
$288Southwest
Sun, Apr 19 - Wed, Apr 22
Southwest Logo
7:05 am - 11:40 am
STL
-
TYS
3h 35m
1 stop
Southwest Logo
6:35 am - 2:15 pm
TYS
-
STL
8h 40m
2 stops
$290Southwest
Sat, Apr 25 - Fri, May 1
Southwest Logo
5:25 am - 2:05 pm
STL
-
TYS
7h 40m
2 stops
Southwest Logo
5:50 pm - 10:00 pm
TYS
-
STL
5h 10m
1 stop
$293Southwest
Sun, Apr 19 - Wed, Apr 22
American Airlines Logo
6:11 pm - 11:56 pm
STL
-
TYS
4h 45m
1 stop
American Airlines Logo
7:00 am - 12:48 pm
TYS
-
STL
6h 48m
1 stop
$298American Airlines
Fri, Apr 17 - Thu, Apr 23
American Airlines Logo
6:29 am - 1:15 pm
STL
-
TYS
5h 46m
1 stop
American Airlines Logo
6:12 am - 10:37 am
TYS
-
STL
5h 25m
1 stop
$299American Airlines
Sun, May 17 - Thu, May 21
Southwest Logo
6:10 am - 6:30 pm
STL
-
TYS
11h 20m
2 stops
Southwest Logo
6:35 am - 12:30 pm
TYS
-
STL
6h 55m
2 stops
$301Southwest
Sat, Apr 25 - Fri, May 1

American Airlines flights from St. Louis to Knoxville

Our best American Airlines deals on St. Louis to Knoxville flight tickets
American Airlines
May 28
STL5:18 pmLambert-St Louis
5h 38m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
Jun 2
TYS6:12 amKnoxville McGhee Tyson
5h 25m
1 stop
STL10:37 amLambert-St Louis
$277
American Airlines
Apr 17
STL6:11 pmLambert-St Louis
4h 45m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
Apr 23
TYS7:00 amKnoxville McGhee Tyson
6h 48m
1 stop
STL12:48 pmLambert-St Louis
$298
American Airlines
May 17
STL6:29 amLambert-St Louis
5h 46m
1 stop
TYS1:15 pmKnoxville McGhee Tyson
May 21
TYS6:12 amKnoxville McGhee Tyson
5h 25m
1 stop
STL10:37 amLambert-St Louis
$299

Southwest flights from St. Louis to Knoxville

Our best Southwest deals on St. Louis to Knoxville flight tickets
Southwest
Apr 19
STL8:25 amLambert-St Louis
4h 40m
1 stop
TYS2:05 pmKnoxville McGhee Tyson
Apr 22
TYS12:50 pmKnoxville McGhee Tyson
5h 25m
1 stop
STL5:15 pmLambert-St Louis
$288
Southwest
Apr 25
STL7:05 amLambert-St Louis
3h 35m
1 stop
TYS11:40 amKnoxville McGhee Tyson
May 1
TYS6:35 amKnoxville McGhee Tyson
8h 40m
2 stops
STL2:15 pmLambert-St Louis
$290
Southwest
Apr 19
STL5:25 amLambert-St Louis
7h 40m
2 stops
TYS2:05 pmKnoxville McGhee Tyson
Apr 22
TYS5:50 pmKnoxville McGhee Tyson
5h 10m
1 stop
STL10:00 pmLambert-St Louis
$293

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 30, 2026.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 4/16

8:06 pm-5:30 pm

2 stops20h 24m

Knoxville McGhee Tyson

Mon 4/20

1:15 pm-11:19 pm

1 stop11h 04m

$263

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 5/28

5:18 pm-11:56 pm

1 stop5h 38m

Knoxville McGhee Tyson

Tue 6/2

6:12 am-10:37 am

1 stop5h 25m

$277

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 4/16

4:59 pm-5:30 pm

1 stop23h 31m

Knoxville McGhee Tyson

Mon 4/20

1:15 pm-11:19 pm

1 stop11h 04m

$283
Quickest round-trip

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 4/25

5:00 pm-11:54 pm

1 stop5h 54m

Knoxville McGhee Tyson

Fri 5/1

5:40 am-8:30 am

1 stop3h 50m

$285

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 4/19

8:25 am-2:05 pm

1 stop4h 40m

Knoxville McGhee Tyson

Wed 4/22

12:50 pm-5:15 pm

1 stop5h 25m

$288

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 4/25

7:05 am-11:40 am

1 stop3h 35m

Knoxville McGhee Tyson

Fri 5/1

6:35 am-2:15 pm

2 stops8h 40m

$290

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 4/19

5:25 am-2:05 pm

2 stops7h 40m

Knoxville McGhee Tyson

Wed 4/22

5:50 pm-10:00 pm

1 stop5h 10m

$293

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 4/17

6:11 pm-11:56 pm

1 stop4h 45m

Knoxville McGhee Tyson

Thu 4/23

7:00 am-12:48 pm

1 stop6h 48m

$298

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 5/17

6:29 am-1:15 pm

1 stop5h 46m

Knoxville McGhee Tyson

Thu 5/21

6:12 am-10:37 am

1 stop5h 25m

$299

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 4/25

6:10 am-6:30 pm

2 stops11h 20m

Knoxville McGhee Tyson

Fri 5/1

6:35 am-12:30 pm

2 stops6h 55m

$301

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from St. Louis to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from St. Louis, with most prices found around $273. If you aren’t able to travel during the month of July, then book flights to Knoxville from St. Louis during August instead. Flights to Knoxville in August, while not as cheap as those in July, still average around $277.

How have St. Louis to Knoxville flight prices changed over time?

As of March 2026, prices for St. Louis to Knoxville flights are approximately 40% more expensive when compared to flights at the same time last year.

When to book flights from St. Louis to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Knoxville (STL to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Knoxville

Fastest flight time

2h 35m

Direct flights

None
The fastest flight from St. Louis to Knoxville takes 2h 35m
There are no direct flights from St. Louis to Knoxville. There are no popular flight routes from St. Louis to Knoxville.
Search flight deals

  • How far is Lambert-St Louis to Knoxville McGhee Tyson by plane?

    Lambert-St Louis and Knoxville McGhee Tyson are 390.7 mi apart from one another. Flights usually cover this in 2h 35m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Knoxville?

Best airlines flying from St. Louis to Knoxville

Compare and see reviews for airlines that fly from St. Louis to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $213Free CancellationRating
7.1
11,530 reviews
Search American Airlines flights
DeltaPriceFrom $228Free CancellationRating
7.9
8,358 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from St. Louis to Knoxville?

momondo helps you find the best flight between St. Louis and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from St. Louis to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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