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Cheap flights from St. Louis to Knoxville from $117

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Knoxville departing on 10/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from St. Louis to Knoxville

Cheap round-trip flights

United Airlines Logo
5:30 pm - 10:37 pmSTL-TYS
4h 07m1 stop
United Airlines Logo
5:45 am - 10:02 amTYS-STL
5h 17m1 stop
$194United Airlines
Find Deal
Sat, Aug 30 - Sun, Aug 31
Delta Logo
1:26 pm - 7:03 pmSTL-TYS
4h 37m1 stop
Delta Logo
6:14 pm - 10:02 pmTYS-STL
4h 48m1 stop
$214Delta
Find Deal
Wed, Aug 27 - Sun, Aug 31
Frontier Logo
7:54 pm - 7:41 pmSTL-TYS
22h 47m1 stop
Frontier Logo
7:10 pm - 9:11 amTYS-STL
15h 01m1 stop
$215Frontier
Find Deal
Sat, Aug 23 - Mon, Sep 1
Frontier Logo
7:55 pm - 7:45 pmSTL-TYS
22h 50m1 stop
Frontier Logo
8:40 pm - 9:06 amTYS-STL
13h 26m1 stop
$225Frontier
Find Deal
Sun, Sep 7 - Thu, Sep 11
American Airlines Logo
5:15 am - 11:30 amSTL-TYS
5h 15m1 stop
American Airlines Logo
2:23 pm - 8:22 pmTYS-STL
6h 59m1 stop
$229American Airlines
Find Deal
Thu, Aug 28 - Sat, Aug 30
American Airlines Logo
5:15 am - 1:36 pmSTL-TYS
7h 21m1 stop
American Airlines Logo
7:35 pm - 11:05 pmTYS-STL
4h 30m1 stop
$234American Airlines
Find Deal
Mon, Aug 11 - Mon, Aug 18
American Airlines Logo
2:45 pm - 9:09 pmSTL-TYS
5h 24m1 stop
American Airlines Logo
5:26 pm - 11:05 pmTYS-STL
6h 39m1 stop
$239American Airlines
Find Deal
Thu, Aug 14 - Mon, Aug 18
American Airlines Logo
2:45 pm - 9:09 pmSTL-TYS
5h 24m1 stop
American Airlines Logo
12:51 pm - 3:52 pmTYS-STL
4h 01m1 stop
$249American Airlines
Find Deal
Thu, Aug 28 - Thu, Sep 4
Delta Logo
6:01 am - 1:07 pmSTL-TYS
6h 06m1 stop
Delta Logo
7:11 pm - 11:24 pmTYS-STL
5h 13m1 stop
$254Delta
Find Deal
Thu, Sep 18 - Mon, Sep 22
United Airlines Logo
5:11 pm - 11:43 pmSTL-TYS
5h 32m1 stop
United Airlines Logo
7:00 am - 10:49 amTYS-STL
4h 49m1 stop
$328United Airlines
Find Deal
Thu, Oct 9 - Tue, Oct 14

United Airlines flights from St. Louis to Knoxville

Our best United Airlines deals on St. Louis to Knoxville flight tickets
United Airlines
Aug 30
STL5:30 pmLambert-St Louis
4h 07m
1 stop
TYS10:37 pmKnoxville McGhee Tyson
Aug 31
TYS5:45 amKnoxville McGhee Tyson
5h 17m
1 stop
STL10:02 amLambert-St Louis
$194
Find similar
United Airlines
Oct 9
STL5:11 pmLambert-St Louis
5h 32m
1 stop
TYS11:43 pmKnoxville McGhee Tyson
Oct 14
TYS7:00 amKnoxville McGhee Tyson
4h 49m
1 stop
STL10:49 amLambert-St Louis
$328
Find similar
United Airlines
Aug 22
STL5:30 pmLambert-St Louis
4h 06m
1 stop
TYS10:36 pmKnoxville McGhee Tyson
Aug 25
TYS7:25 pmKnoxville McGhee Tyson
21h 19m
2 stops
STL3:44 pmLambert-St Louis
$344
Find similar

American Airlines flights from St. Louis to Knoxville

Our best American Airlines deals on St. Louis to Knoxville flight tickets
American Airlines
Aug 28
STL5:15 amLambert-St Louis
5h 15m
1 stop
TYS11:30 amKnoxville McGhee Tyson
Aug 30
TYS2:23 pmKnoxville McGhee Tyson
6h 59m
1 stop
STL8:22 pmLambert-St Louis
$229
Find similar
American Airlines
Aug 11
STL5:15 amLambert-St Louis
7h 21m
1 stop
TYS1:36 pmKnoxville McGhee Tyson
Aug 18
TYS7:35 pmKnoxville McGhee Tyson
4h 30m
1 stop
STL11:05 pmLambert-St Louis
$234
Find similar
American Airlines
Aug 14
STL2:45 pmLambert-St Louis
5h 24m
1 stop
TYS9:09 pmKnoxville McGhee Tyson
Aug 18
TYS5:26 pmKnoxville McGhee Tyson
6h 39m
1 stop
STL11:05 pmLambert-St Louis
$239
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 8/30

5:30 pm-10:37 pm

1 stop4h 07m

Knoxville McGhee Tyson

Sun 8/31

5:45 am-10:02 am

1 stop5h 17m

$194

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 8/27

1:26 pm-7:03 pm

1 stop4h 37m

Knoxville McGhee Tyson

Sun 8/31

6:14 pm-10:02 pm

1 stop4h 48m

$214

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 8/23

7:54 pm-7:41 pm

1 stop22h 47m

Knoxville McGhee Tyson

Mon 9/1

7:10 pm-9:11 am

1 stop15h 01m

$215

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 9/7

7:55 pm-7:45 pm

1 stop22h 50m

Knoxville McGhee Tyson

Thu 9/11

8:40 pm-9:06 am

1 stop13h 26m

$225

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 8/28

5:15 am-11:30 am

1 stop5h 15m

Knoxville McGhee Tyson

Sat 8/30

2:23 pm-8:22 pm

1 stop6h 59m

$229

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 8/11

5:15 am-1:36 pm

1 stop7h 21m

Knoxville McGhee Tyson

Mon 8/18

7:35 pm-11:05 pm

1 stop4h 30m

$234

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 8/14

2:45 pm-9:09 pm

1 stop5h 24m

Knoxville McGhee Tyson

Mon 8/18

5:26 pm-11:05 pm

1 stop6h 39m

$239

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 8/28

2:45 pm-9:09 pm

1 stop5h 24m

Knoxville McGhee Tyson

Thu 9/4

12:51 pm-3:52 pm

1 stop4h 01m

$249

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 9/18

6:01 am-1:07 pm

1 stop6h 06m

Knoxville McGhee Tyson

Mon 9/22

7:11 pm-11:24 pm

1 stop5h 13m

$254

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 10/9

5:11 pm-11:43 pm

1 stop5h 32m

Knoxville McGhee Tyson

Tue 10/14

7:00 am-10:49 am

1 stop4h 49m

$328

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from St. Louis to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from St. Louis, with most prices found around $255. If you aren’t able to travel during the month of July, then book flights to Knoxville from St. Louis during November instead. Flights to Knoxville in November, while not as cheap as those in July, still average around $260.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from St. Louis to Knoxville is on a Thursday. Travelers who choose to depart for Knoxville on a Thursday will often find tickets for as low as $274. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from St. Louis to Knoxville for around $518.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from St. Louis to Knoxville when you can find flight prices for as low as $280. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $388.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $340 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from St. Louis for as low as $171 on momondo.

How have St. Louis to Knoxville flight prices changed over time?

As of July 2025, prices for St. Louis to Knoxville flights are approximately 50% cheaper when compared to flights at the same time last year.

When to book flights from St. Louis to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Knoxville (STL to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Knoxville

Best Price Found

$117

Fastest flight time

3h 49m

Direct flights

None

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from St. Louis in the past 72 hours is $117. The best round-trip flight deal from St. Louis to Knoxville found on momondo in the last 72 hours is $194.
The fastest flight from St. Louis to Knoxville takes 3h 49m
There are no direct flights from St. Louis to Knoxville. Popular non-direct route for this connection is Lambert-St Louis Airport - Knoxville McGhee Tyson Airport.
There is 1 airport near Knoxville: Knoxville McGhee Tyson (TYS)
Search flight deals

  • How far is Lambert-St Louis to Knoxville McGhee Tyson by plane?

    Lambert-St Louis and Knoxville McGhee Tyson are 390.7 mi apart from one another. Flights usually cover this in 3h 49m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Knoxville?

Best airlines flying from St. Louis to Knoxville

Compare and see reviews for airlines that fly from St. Louis to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $213Free CancellationRating
7.4
8,900 reviews
Search United Airlines flights
American AirlinesPriceFrom $213Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $222Free CancellationRating
8.0
7,981 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Alcoa
Lenoir City
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from St. Louis to Knoxville?

momondo helps you find the best flight between St. Louis and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from St. Louis to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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