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Cheap flights from St. Louis to Knoxville from $122

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:05 am - 11:27 amSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
5h 22m1 stop Chicago O'Hare Intl
American Airlines Logo
8:51 pm - 11:57 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
4h 06m1 stop Chicago O'Hare Intl
$243American Airlines
Thu, Jan 7 - Mon, Jan 11
American Airlines Logo
11:35 am - 4:29 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
3h 54m1 stop Chicago O'Hare Intl
American Airlines Logo
5:30 pm - 10:14 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
5h 44m1 stop Dallas/Fort Worth
$243American Airlines
Tue, Nov 17 - Sat, Nov 21
Delta Logo
12:36 pm - 6:30 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
4h 54m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:36 pm - 8:09 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
6h 33m1 stop Atlanta Hartsfield-Jackson
$243Delta
Thu, Dec 10 - Sat, Dec 12
Delta Logo
2:33 pm - 6:56 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
3h 23m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:40 am - 11:29 amTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
6h 49m1 stop Atlanta Hartsfield-Jackson
$243Delta
Tue, Dec 8 - Sat, Dec 12
American Airlines Logo
5:29 pm - 10:51 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
4h 22m1 stop Chicago O'Hare Intl
American Airlines Logo
6:05 pm - 11:58 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
6h 53m1 stop Charlotte Douglas
$243American Airlines
Tue, Nov 17 - Sat, Nov 21
Delta Logo
5:38 pm - 10:22 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
3h 44m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:23 pm - 11:54 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
6h 31m1 stop Atlanta Hartsfield-Jackson
$243Delta
Sat, Oct 17 - Tue, Oct 20
Southwest Logo
11:30 am - 7:45 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
7h 15m2 stops Chicago Midway Baltimore/Washington
Southwest Logo
4:45 pm - 9:45 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
6h 00m1 stop Nashville Intl
$248Southwest
Thu, Jan 7 - Mon, Jan 11
Southwest Logo
10:30 am - 8:45 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
9h 15m2 stops Nashville Intl Baltimore/Washington
Southwest Logo
2:50 pm - 8:05 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
6h 15m1 stop Nashville Intl
$248Southwest
Wed, Dec 9 - Sat, Dec 12
United Airlines Logo
1:29 pm - 8:49 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
6h 20m1 stop Chicago O'Hare Intl
United Airlines Logo
10:45 am - 4:59 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
7h 14m1 stop Chicago O'Hare Intl
$263United Airlines
Wed, Oct 21 - Wed, Oct 28
United Airlines Logo
3:03 pm - 10:14 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
6h 11m1 stop Houston George Bush Intcntl
United Airlines Logo
12:00 pm - 4:43 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
5h 43m1 stop Houston George Bush Intcntl
$333United Airlines
Sat, Jan 30 - Wed, Feb 3

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Southwest flights from St. Louis to Knoxville

Our best Southwest deals on St. Louis to Knoxville flight tickets
Southwest
Jan 7
STL11:30 amLambert-St Louis
7h 15m
2 stops
TYS7:45 pmKnoxville McGhee Tyson
Jan 11
TYS4:45 pmKnoxville McGhee Tyson
6h 00m
1 stop
STL9:45 pmLambert-St Louis
$248
Southwest
Nov 3
STL10:55 amLambert-St Louis
8h 50m
2 stops
TYS8:45 pmKnoxville McGhee Tyson
Nov 9
TYS7:25 pmKnoxville McGhee Tyson
5h 30m
1 stop
STL11:55 pmLambert-St Louis
$259
Southwest
Oct 24
STL11:55 amLambert-St Louis
5h 00m
1 stop
TYS5:55 pmKnoxville McGhee Tyson
Oct 28
TYS8:20 amKnoxville McGhee Tyson
7h 40m
2 stops
STL3:00 pmLambert-St Louis
$270

Delta flights from St. Louis to Knoxville

Our best Delta deals on St. Louis to Knoxville flight tickets
Delta
Oct 21
STL12:00 pmLambert-St Louis
4h 28m
1 stop
TYS5:28 pmKnoxville McGhee Tyson
Oct 24
TYS5:40 amKnoxville McGhee Tyson
5h 02m
1 stop
STL9:42 amLambert-St Louis
$243
Delta
Nov 17
STL2:31 pmLambert-St Louis
3h 18m
1 stop
TYS6:49 pmKnoxville McGhee Tyson
Nov 21
TYS6:10 pmKnoxville McGhee Tyson
4h 24m
1 stop
STL9:34 pmLambert-St Louis
$276

momondo Fare Finder

 
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

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St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Thu 1/7

5:05 am-11:27 am

1 stop5h 22m

Knoxville McGhee Tyson

Mon 1/11

8:51 pm-11:57 pm

1 stop4h 06m

$243

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Tue 11/17

11:35 am-4:29 pm

1 stop3h 54m

Knoxville McGhee Tyson

Sat 11/21

5:30 pm-10:14 pm

1 stop5h 44m

$243

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Thu 12/10

12:36 pm-6:30 pm

1 stop4h 54m

Knoxville McGhee Tyson

Sat 12/12

2:36 pm-8:09 pm

1 stop6h 33m

$243

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Tue 12/8

2:33 pm-6:56 pm

1 stop3h 23m

Knoxville McGhee Tyson

Sat 12/12

5:40 am-11:29 am

1 stop6h 49m

$243

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Tue 11/17

5:29 pm-10:51 pm

1 stop4h 22m

Knoxville McGhee Tyson

Sat 11/21

6:05 pm-11:58 pm

1 stop6h 53m

$243

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Sat 10/17

5:38 pm-10:22 pm

1 stop3h 44m

Knoxville McGhee Tyson

Tue 10/20

6:23 pm-11:54 pm

1 stop6h 31m

$243

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Thu 1/7

11:30 am-7:45 pm

2 stops7h 15m

Knoxville McGhee Tyson

Mon 1/11

4:45 pm-9:45 pm

1 stop6h 00m

$248

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Wed 12/9

10:30 am-8:45 pm

2 stops9h 15m

Knoxville McGhee Tyson

Sat 12/12

2:50 pm-8:05 pm

1 stop6h 15m

$248

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Wed 10/21

1:29 pm-8:49 pm

1 stop6h 20m

Knoxville McGhee Tyson

Wed 10/28

10:45 am-4:59 pm

1 stop7h 14m

$263

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Sat 1/30

3:03 pm-10:14 pm

1 stop6h 11m

Knoxville McGhee Tyson

Wed 2/3

12:00 pm-4:43 pm

1 stop5h 43m

$333

Flights are sorted by cheapest round-trip flights first.

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See travel insights to Knoxville from

How to get the cheapest flight ticket from St. Louis to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $273 to $446.
The lowest price recently found on this route was $243.

What is the cheapest month to fly to Knoxville?

The month of November is, on average, the cheapest month to fly to Knoxville from St. Louis, with most prices found around $278. If you aren’t able to travel during the month of November, then book flights to Knoxville from St. Louis during August instead. Flights to Knoxville in August, while not as cheap as those in November, still average around $278.

Can stopping save me money on St. Louis to Knoxville flights?

You could potentially save up to 44% on your flight if you consider stops on a St. Louis to Knoxville flight.

How have St. Louis to Knoxville flight prices changed over time?

As of September 2026, prices for St. Louis to Knoxville flights are approximately 71% more expensive when compared to flights at the same time last year.

When to book flights from St. Louis to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Knoxville (STL to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Knoxville

Best Price Found

$122

Fastest flight time

3h 05m

Direct flights

None
The best one-way flight to Knoxville from St. Louis in the past 72 hours is $122. The best round-trip flight deal from St. Louis to Knoxville found on momondo in the last 72 hours is $243.
The fastest flight from St. Louis to Knoxville takes 3h 05m
There are no direct flights from St. Louis to Knoxville. There are no popular flight routes from St. Louis to Knoxville.
Search flight deals

Frequently asked questions about flying from St. Louis to Knoxville

  • How far is Lambert-St Louis to Knoxville McGhee Tyson by plane?

    Lambert-St Louis and Knoxville McGhee Tyson are 390.7 mi apart from one another. Flights usually cover this in 3h 05m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Lambert-St Louis Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from St. Louis to Knoxville?

Best airlines flying from St. Louis to Knoxville

Compare and see reviews for airlines that fly from St. Louis to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $210Free CancellationRating
7.0
12,099 reviews
Search American Airlines flights
DeltaPriceFrom $210Free CancellationRating
7.8
8,610 reviews
Search Delta flights
SouthwestPriceFrom $248Free CancellationRating
8.0
4,201 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Rockford
Jefferson City

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from St. Louis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from St. Louis to Knoxville?

momondo helps you find the best flight between St. Louis and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from St. Louis to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from St. Louis to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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