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Cheap flights from St. Louis to Key West from $218

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Key West departing on 1/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Multiple Airlines Logo
5:11 pm - 9:26 amSTL-EYW
15h 15m1 stop
Multiple Airlines Logo
1:06 pm - 10:33 pmEYW-STL
10h 27m1 stop
$218Multiple Airlines
Find Deal
Wed, Jan 28 - Fri, Feb 6
American Airlines Logo
4:36 pm - 11:07 pmSTL-EYW
5h 31m1 stop
American Airlines Logo
8:05 pm - 11:59 pmEYW-STL
4h 54m1 stop
$223American Airlines
Find Deal
Wed, Dec 3 - Sat, Dec 6
American Airlines Logo
2:11 pm - 11:07 pmSTL-EYW
7h 56m2 stops
American Airlines Logo
4:59 pm - 10:47 pmEYW-STL
6h 48m1 stop
$228American Airlines
Find Deal
Wed, Dec 3 - Sat, Dec 6
Multiple Airlines Logo
5:11 pm - 12:26 pmSTL-EYW
18h 15m1 stop
Multiple Airlines Logo
10:06 am - 7:54 amEYW-STL
22h 48m1 stop
$230Multiple Airlines
Find Deal
Thu, Jan 8 - Thu, Jan 15
Multiple Airlines Logo
12:20 pm - 1:30 pmSTL-EYW
24h 10m1 stop
Multiple Airlines Logo
10:06 am - 7:54 amEYW-STL
22h 48m1 stop
$232Multiple Airlines
Find Deal
Thu, Jan 8 - Thu, Jan 15
Delta Logo
1:57 pm - 8:06 pmSTL-EYW
5h 09m1 stop
Delta Logo
6:20 pm - 11:42 pmEYW-STL
6h 22m1 stop
$241Delta
Find Deal
Sun, Dec 14 - Sat, Dec 20
Delta Logo
10:00 am - 5:13 pmSTL-EYW
6h 13m1 stop
Delta Logo
2:35 pm - 6:04 pmEYW-STL
4h 29m1 stop
$266Delta
Find Deal
Tue, Feb 24 - Thu, Mar 5
Spirit Airlines Logo
9:52 am - 11:20 amSTL-EYW
24h 28m1 stop
Spirit Airlines Logo
2:30 pm - 1:52 pmEYW-STL
24h 22m1 stop
$292Spirit Airlines
Find Deal
Sat, Nov 29 - Sat, Dec 6
United Airlines Logo
6:00 am - 3:53 pmSTL-EYW
8h 53m1 stop
United Airlines Logo
4:53 pm - 10:13 pmEYW-STL
6h 20m1 stop
$301United Airlines
Find Deal
Sat, Feb 28 - Sat, Mar 7
United Airlines Logo
8:05 am - 3:14 pmSTL-EYW
6h 09m1 stop
United Airlines Logo
4:29 pm - 9:55 pmEYW-STL
6h 26m1 stop
$313United Airlines
Find Deal
Sun, Dec 21 - Sat, Dec 27

American Airlines flights from St. Louis to Key West

Our best American Airlines deals on St. Louis to Key West flight tickets
American Airlines
Dec 3
STL4:36 pmLambert-St Louis
5h 31m
1 stop
EYW11:07 pmKey West
Dec 6
EYW8:05 pmKey West
4h 54m
1 stop
STL11:59 pmLambert-St Louis
$223
Find similar
American Airlines
Dec 3
STL2:11 pmLambert-St Louis
7h 56m
2 stops
EYW11:07 pmKey West
Dec 6
EYW4:59 pmKey West
6h 48m
1 stop
STL10:47 pmLambert-St Louis
$228
Find similar
American Airlines
Dec 3
STL9:53 amLambert-St Louis
8h 42m
2 stops
EYW7:35 pmKey West
Dec 6
EYW7:00 amKey West
7h 18m
2 stops
STL1:18 pmLambert-St Louis
$233
Find similar

Delta flights from St. Louis to Key West

Our best Delta deals on St. Louis to Key West flight tickets
Delta
Dec 14
STL1:57 pmLambert-St Louis
5h 09m
1 stop
EYW8:06 pmKey West
Dec 20
EYW6:20 pmKey West
6h 22m
1 stop
STL11:42 pmLambert-St Louis
$241
Find similar
Delta
Feb 24
STL1:00 pmLambert-St Louis
5h 44m
1 stop
EYW7:44 pmKey West
Mar 3
EYW6:00 pmKey West
6h 40m
1 stop
STL11:40 pmLambert-St Louis
$266
Find similar
Delta
Nov 16
STL6:00 amLambert-St Louis
4h 31m
1 stop
EYW11:31 amKey West
Nov 22
EYW7:40 amKey West
5h 46m
1 stop
STL12:26 pmLambert-St Louis
$284
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from St. Louis to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 1/28

5:11 pm-9:26 am

1 stop15h 15m

Key West

Fri 2/6

1:06 pm-10:33 pm

1 stop10h 27m

$218

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 12/3

4:36 pm-11:07 pm

1 stop5h 31m

Key West

Sat 12/6

8:05 pm-11:59 pm

1 stop4h 54m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 12/3

2:11 pm-11:07 pm

2 stops7h 56m

Key West

Sat 12/6

4:59 pm-10:47 pm

1 stop6h 48m

$228

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Thu 1/8

5:11 pm-12:26 pm

1 stop18h 15m

Key West

Thu 1/15

10:06 am-7:54 am

1 stop22h 48m

$230

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Thu 1/8

12:20 pm-1:30 pm

1 stop24h 10m

Key West

Thu 1/15

10:06 am-7:54 am

1 stop22h 48m

$232

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sun 12/14

1:57 pm-8:06 pm

1 stop5h 09m

Key West

Sat 12/20

6:20 pm-11:42 pm

1 stop6h 22m

$241

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 2/24

10:00 am-5:13 pm

1 stop6h 13m

Key West

Thu 3/5

2:35 pm-6:04 pm

1 stop4h 29m

$266

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 11/29

9:52 am-11:20 am

1 stop24h 28m

Key West

Sat 12/6

2:30 pm-1:52 pm

1 stop24h 22m

$292

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 2/28

6:00 am-3:53 pm

1 stop8h 53m

Key West

Sat 3/7

4:53 pm-10:13 pm

1 stop6h 20m

$301

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sun 12/21

8:05 am-3:14 pm

1 stop6h 09m

Key West

Sat 12/27

4:29 pm-9:55 pm

1 stop6h 26m

$313

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from St. Louis to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, August is the cheapest month to fly from St. Louis to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $353. If you are unable to visit Key West during the month of August, then departing from St. Louis during the month December is also very affordable. Most momondo users find prices during this month for around $361.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from St. Louis is on a Friday. momondo users have found tickets for Friday departures for as low as $376. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from St. Louis to Key West for around $557.

What is the cheapest time of day to depart on your flight to Key West?

According to our data, the cheapest time of day to fly to Key West is at noon. momondo users have found flights departing from St. Louis to Key West at noon for as low as $394. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Key West are more costly in the afternoon, with an average ticket price of $470. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $429 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from St. Louis for as low as $291 on momondo.

When to book flights from St. Louis to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Key West (STL to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Key West

Direct flights

None
There are no direct flights from St. Louis to Key West. There are no popular flight routes from St. Louis to Key West.
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  • How far is Lambert-St Louis to Key West by plane?

    A flight from Lambert-St Louis to Key West will travel around 1088.7 mi. 4h 31m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Key West Airport?

    Prices for flights from Lambert-St Louis Airport to Key West Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Key West Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Key West Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Key West?

Best airlines flying from St. Louis to Key West

Compare and see reviews for airlines that fly from St. Louis to Key West with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $216Free CancellationRating
7.9
7,998 reviews
Search Delta flights
American AirlinesPriceFrom $239Free CancellationRating
7.2
11,035 reviews
Search American Airlines flights
United AirlinesPriceFrom $245Free CancellationRating
7.4
8,998 reviews
Search United Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Key West?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from St. Louis to Key West for you.

Can I find flights from St. Louis to Key West with flexible booking policies on momondo?

Flights from St. Louis to Key West with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Key West?

Once you have performed a search for St. Louis to Key West flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from St. Louis to Key West right now. Can momondo alert me if prices change?

Yes. momondo can track prices for St. Louis to Key West flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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