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Cheap flights from St. Louis to Key West from $223

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Key West departing on 4/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from St. Louis to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
10:12 am - 5:30 pm
STL
-
EYW
6h 18m
1 stop
Delta Logo
6:23 pm - 11:36 pm
EYW
-
STL
6h 13m
1 stop
$223Delta
Wed, Apr 8 - Wed, Apr 15
American Airlines Logo
12:25 pm - 10:58 pm
STL
-
EYW
9h 33m
2 stops
American Airlines Logo
6:49 pm - 11:56 pm
EYW
-
STL
6h 07m
1 stop
$228American Airlines
Wed, May 6 - Tue, May 12
American Airlines Logo
11:22 am - 7:12 pm
STL
-
EYW
6h 50m
1 stop
American Airlines Logo
6:49 pm - 11:44 pm
EYW
-
STL
5h 55m
1 stop
$251American Airlines
Wed, Mar 18 - Wed, Mar 25
American Airlines Logo
6:00 am - 4:49 pm
STL
-
EYW
9h 49m
2 stops
American Airlines Logo
2:26 pm - 8:16 pm
EYW
-
STL
6h 50m
1 stop
$256American Airlines
Wed, Mar 18 - Wed, Mar 25
Multiple Airlines Logo
4:51 pm - 9:06 am
STL
-
EYW
15h 15m
1 stop
Multiple Airlines Logo
9:49 am - 10:32 am
EYW
-
STL
25h 43m
2 stops
$258Multiple Airlines
Wed, Mar 11 - Mon, Mar 23
American Airlines Logo
9:37 am - 7:12 pm
STL
-
EYW
8h 35m
2 stops
American Airlines Logo
7:45 am - 3:35 pm
EYW
-
STL
8h 50m
2 stops
$261American Airlines
Wed, Mar 18 - Wed, Mar 25
Delta Logo
12:04 pm - 7:41 pm
STL
-
EYW
6h 37m
1 stop
Delta Logo
6:25 pm - 11:58 pm
EYW
-
STL
6h 33m
1 stop
$266Delta
Tue, Mar 31 - Sat, Apr 4
Multiple Airlines Logo
4:51 pm - 9:06 am
STL
-
EYW
15h 15m
1 stop
Multiple Airlines Logo
1:01 pm - 10:37 am
EYW
-
STL
22h 36m
2 stops
$270Multiple Airlines
Wed, Mar 11 - Tue, Mar 17
Delta Logo
9:00 am - 5:14 pm
STL
-
EYW
7h 14m
1 stop
Delta Logo
11:45 am - 6:02 pm
EYW
-
STL
7h 17m
1 stop
$271Delta
Tue, Aug 4 - Tue, Aug 11
Multiple Airlines Logo
3:49 pm - 9:06 am
STL
-
EYW
16h 17m
1 stop
Multiple Airlines Logo
9:46 am - 1:19 pm
EYW
-
STL
28h 33m
2 stops
$286Multiple Airlines
Wed, Mar 4 - Sun, Mar 8

Delta flights from St. Louis to Key West

Our best Delta deals on St. Louis to Key West flight tickets
Delta
Apr 8
STL10:12 amLambert-St Louis
6h 18m
1 stop
EYW5:30 pmKey West
Apr 15
EYW6:23 pmKey West
6h 13m
1 stop
STL11:36 pmLambert-St Louis
$223
Delta
Mar 31
STL12:04 pmLambert-St Louis
6h 37m
1 stop
EYW7:41 pmKey West
Apr 4
EYW6:25 pmKey West
6h 33m
1 stop
STL11:58 pmLambert-St Louis
$266
Delta
Aug 4
STL9:00 amLambert-St Louis
7h 14m
1 stop
EYW5:14 pmKey West
Aug 11
EYW11:45 amKey West
7h 17m
1 stop
STL6:02 pmLambert-St Louis
$271

American Airlines flights from St. Louis to Key West

Our best American Airlines deals on St. Louis to Key West flight tickets
American Airlines
May 6
STL12:25 pmLambert-St Louis
9h 33m
2 stops
EYW10:58 pmKey West
May 12
EYW6:49 pmKey West
6h 07m
1 stop
STL11:56 pmLambert-St Louis
$228
American Airlines
Mar 18
STL11:22 amLambert-St Louis
6h 50m
1 stop
EYW7:12 pmKey West
Mar 25
EYW6:49 pmKey West
5h 55m
1 stop
STL11:44 pmLambert-St Louis
$251
American Airlines
Mar 18
STL6:00 amLambert-St Louis
9h 49m
2 stops
EYW4:49 pmKey West
Mar 25
EYW2:26 pmKey West
6h 50m
1 stop
STL8:16 pmLambert-St Louis
$256

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 22, 2026.
Use the filters below to find and compare flights from St. Louis to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 4/8

10:12 am-5:30 pm

1 stop6h 18m

Key West

Wed 4/15

6:23 pm-11:36 pm

1 stop6h 13m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 5/6

12:25 pm-10:58 pm

2 stops9h 33m

Key West

Tue 5/12

6:49 pm-11:56 pm

1 stop6h 07m

$228

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 3/18

11:22 am-7:12 pm

1 stop6h 50m

Key West

Wed 3/25

6:49 pm-11:44 pm

1 stop5h 55m

$251

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 3/18

6:00 am-4:49 pm

2 stops9h 49m

Key West

Wed 3/25

2:26 pm-8:16 pm

1 stop6h 50m

$256

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 3/11

4:51 pm-9:06 am

1 stop15h 15m

Key West

Mon 3/23

9:49 am-10:32 am

2 stops25h 43m

$258

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 3/18

9:37 am-7:12 pm

2 stops8h 35m

Key West

Wed 3/25

7:45 am-3:35 pm

2 stops8h 50m

$261

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 3/31

12:04 pm-7:41 pm

1 stop6h 37m

Key West

Sat 4/4

6:25 pm-11:58 pm

1 stop6h 33m

$266

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 3/11

4:51 pm-9:06 am

1 stop15h 15m

Key West

Tue 3/17

1:01 pm-10:37 am

2 stops22h 36m

$270

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 8/4

9:00 am-5:14 pm

1 stop7h 14m

Key West

Tue 8/11

11:45 am-6:02 pm

1 stop7h 17m

$271

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 3/4

3:49 pm-9:06 am

1 stop16h 17m

Key West

Sun 3/8

9:46 am-1:19 pm

2 stops28h 33m

$286

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from St. Louis to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, December is the cheapest month to fly from St. Louis to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $283. If you are unable to visit Key West during the month of December, then departing from St. Louis during the month January is also very affordable. Most momondo users find prices during this month for around $328.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $420 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from St. Louis for as low as $290 on momondo.

When to book flights from St. Louis to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Key West (STL to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Key West

Fastest flight time

5h 14m

Direct flights

None
The fastest flight from St. Louis to Key West takes 5h 14m
There are no direct flights from St. Louis to Key West. There are no popular flight routes from St. Louis to Key West.
Search flight deals

  • How far is Lambert-St Louis to Key West by plane?

    A flight from Lambert-St Louis to Key West will travel around 1088.7 mi. 5h 14m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Key West Airport?

    Prices for flights from Lambert-St Louis Airport to Key West Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Key West Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Key West Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The necessary travel and health documents for your Key West Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Key West?

Best airlines flying from St. Louis to Key West

Compare and see reviews for airlines that fly from St. Louis to Key West with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $222Free CancellationRating
7.9
8,241 reviews
Search Delta flights
American AirlinesPriceFrom $222Free CancellationRating
7.2
11,338 reviews
Search American Airlines flights
United AirlinesPriceFrom $376Free CancellationRating
7.4
9,341 reviews
Search United Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Key West?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from St. Louis to Key West for you.

Can I find flights from St. Louis to Key West with flexible booking policies on momondo?

Flights from St. Louis to Key West with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Key West?

Once you have performed a search for St. Louis to Key West flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from St. Louis to Key West right now. Can momondo alert me if prices change?

Yes. momondo can track prices for St. Louis to Key West flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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