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Cheap flights from South Carolina to Knoxville from $98

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Knoxville departing on 8/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Carolina to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:41 pm - 8:32 am
CLT
-
TYS
13h 51m
1 stop
Multiple Airlines Logo
7:15 am - 9:07 pm
TYS
-
CLT
13h 52m
1 stop
$236Multiple Airlines
Fri, Jul 31 - Sun, Aug 2
Multiple Airlines Logo
1:52 pm - 4:42 pm
SAV
-
TYS
26h 50m
1 stop
Multiple Airlines Logo
9:11 pm - 8:19 pm
TYS
-
SAV
47h 08m
2 stops
$238Multiple Airlines
Thu, Jul 23 - Thu, Jul 30
Multiple Airlines Logo
1:52 pm - 4:42 pm
SAV
-
TYS
26h 50m
1 stop
Multiple Airlines Logo
7:15 am - 1:55 pm
TYS
-
SAV
6h 40m
1 stop
$250Multiple Airlines
Thu, Jul 23 - Thu, Jul 30
Southwest Logo
6:50 am - 12:05 pm
CLT
-
TYS
5h 15m
1 stop
Southwest Logo
8:10 am - 2:35 pm
TYS
-
CLT
6h 25m
1 stop
$265Southwest
Wed, Jul 22 - Wed, Jul 29
American Airlines Logo
6:51 am - 10:38 am
MYR
-
TYS
3h 47m
1 stop
American Airlines Logo
1:00 pm - 5:25 pm
TYS
-
MYR
4h 25m
1 stop
$265American Airlines
Wed, Jul 22 - Wed, Jul 29
American Airlines Logo
5:00 am - 10:38 am
SAV
-
TYS
5h 38m
1 stop
American Airlines Logo
10:00 am - 2:27 pm
TYS
-
SAV
4h 27m
1 stop
$265American Airlines
Tue, Jul 21 - Wed, Jul 29
Southwest Logo
6:50 am - 12:05 pm
CLT
-
TYS
5h 15m
1 stop
Southwest Logo
7:10 am - 3:40 pm
TYS
-
CLT
8h 30m
2 stops
$270Southwest
Wed, Jul 22 - Wed, Jul 29
Delta Logo
5:55 am - 9:38 am
CHS
-
TYS
3h 43m
1 stop
Delta Logo
7:43 pm - 12:26 am
TYS
-
CHS
4h 43m
1 stop
$281Delta
Sat, Jul 18 - Wed, Jul 22
United Airlines Logo
2:58 pm - 4:58 pm
HHH
-
TYS
26h 00m
1 stop
United Airlines Logo
6:02 pm - 2:03 pm
TYS
-
HHH
20h 01m
1 stop
$721United Airlines
Wed, Sep 2 - Sat, Sep 5
United Airlines Logo
2:48 pm - 4:58 pm
HHH
-
TYS
26h 10m
1 stop
United Airlines Logo
6:02 pm - 2:03 pm
TYS
-
HHH
20h 01m
1 stop
$757United Airlines
Wed, Sep 2 - Sat, Sep 5

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Delta flights from South Carolina to Knoxville

Our best Delta deals on South Carolina to Knoxville flight tickets
Delta
Jul 18
CHS5:55 amCharleston
3h 43m
1 stop
TYS9:38 amKnoxville McGhee Tyson
Jul 22
TYS7:43 pmKnoxville McGhee Tyson
4h 43m
1 stop
CHS12:26 amCharleston
$281
Delta
Jul 15
MYR11:42 amMyrtle Beach Intl
3h 06m
1 stop
TYS2:48 pmKnoxville McGhee Tyson
Jul 15
TYS7:43 pmKnoxville McGhee Tyson
4h 12m
1 stop
MYR11:55 pmMyrtle Beach Intl
$321
Delta
Jul 15
MYR11:42 amMyrtle Beach Intl
3h 06m
1 stop
TYS2:48 pmKnoxville McGhee Tyson
Jul 15
TYS7:43 pmKnoxville McGhee Tyson
4h 12m
1 stop
MYR11:55 pmMyrtle Beach Intl
$351

Southwest flights from South Carolina to Knoxville

Our best Southwest deals on South Carolina to Knoxville flight tickets
Southwest
Jul 22
CLT6:50 amCharlotte Douglas
5h 15m
1 stop
TYS12:05 pmKnoxville McGhee Tyson
Jul 29
TYS8:10 amKnoxville McGhee Tyson
6h 25m
1 stop
CLT2:35 pmCharlotte Douglas
$265
Southwest
Jul 22
CLT6:50 amCharlotte Douglas
5h 15m
1 stop
TYS12:05 pmKnoxville McGhee Tyson
Jul 29
TYS7:10 amKnoxville McGhee Tyson
8h 30m
2 stops
CLT3:40 pmCharlotte Douglas
$270
Southwest
Aug 15
CLT6:30 amCharlotte Douglas
5h 25m
1 stop
TYS11:55 amKnoxville McGhee Tyson
Aug 17
TYS5:45 pmKnoxville McGhee Tyson
4h 05m
1 stop
CLT9:50 pmCharlotte Douglas
$273

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 26, 2026.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 7/31

6:41 pm-8:32 am

1 stop13h 51m

Knoxville McGhee Tyson

Sun 8/2

7:15 am-9:07 pm

1 stop13h 52m

$236

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Thu 7/23

1:52 pm-4:42 pm

1 stop26h 50m

Knoxville McGhee Tyson

Thu 7/30

9:11 pm-8:19 pm

2 stops47h 08m

$238

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Thu 7/23

1:52 pm-4:42 pm

1 stop26h 50m

Knoxville McGhee Tyson

Thu 7/30

7:15 am-1:55 pm

1 stop6h 40m

$250

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Wed 7/22

6:50 am-12:05 pm

1 stop5h 15m

Knoxville McGhee Tyson

Wed 7/29

8:10 am-2:35 pm

1 stop6h 25m

$265
Quickest round-trip

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 7/22

6:51 am-10:38 am

1 stop3h 47m

Knoxville McGhee Tyson

Wed 7/29

1:00 pm-5:25 pm

1 stop4h 25m

$265

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Tue 7/21

5:00 am-10:38 am

1 stop5h 38m

Knoxville McGhee Tyson

Wed 7/29

10:00 am-2:27 pm

1 stop4h 27m

$265

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Wed 7/22

6:50 am-12:05 pm

1 stop5h 15m

Knoxville McGhee Tyson

Wed 7/29

7:10 am-3:40 pm

2 stops8h 30m

$270

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 7/18

5:55 am-9:38 am

1 stop3h 43m

Knoxville McGhee Tyson

Wed 7/22

7:43 pm-12:26 am

1 stop4h 43m

$281

Hilton Head IslandKnoxville

HHH - TYS

HHHTYS

Hilton Head Island

Wed 9/2

2:58 pm-4:58 pm

1 stop26h 00m

Knoxville McGhee Tyson

Sat 9/5

6:02 pm-2:03 pm

1 stop20h 01m

$721

Hilton Head IslandKnoxville

HHH - TYS

HHHTYS

Hilton Head Island

Wed 9/2

2:48 pm-4:58 pm

1 stop26h 10m

Knoxville McGhee Tyson

Sat 9/5

6:02 pm-2:03 pm

1 stop20h 01m

$757

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from South Carolina to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from South Carolina, with most prices found around $228. If you aren’t able to travel during the month of September, then book flights to Knoxville from South Carolina during January instead. Flights to Knoxville in January, while not as cheap as those in September, still average around $254.

Cheap South Carolina to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Knoxville

Fastest flight time

1h 13m

Direct flights

Every day

Airports in Knoxville

1 airport
The fastest flight from South Carolina to Knoxville takes 1h 13m
Direct flights go from South Carolina to Knoxville every day.
There is 1 airport in Knoxville. From South Carolina there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

Frequently asked questions about flying from South Carolina to Knoxville

  • When did momondo last update prices for flights from South Carolina to Knoxville McGhee Tyson Airport?

    Prices for flights from South Carolina to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from South Carolina to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from South Carolina to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from South Carolina to Knoxville

Compare and see reviews for airlines that fly from South Carolina to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $254Free CancellationRating
7.8
8,453 reviews
Search Delta flights
American AirlinesPriceFrom $283Free CancellationRating
7.1
11,769 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Carolina to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Carolina to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Knoxville?

Once you have performed a search for South Carolina to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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