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Cheap flights from South Carolina to Knoxville from $93

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Knoxville departing on 4/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from South Carolina to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
9:54 pm - 12:06 pm
CLT
-
TYS
14h 12m
1 stop
Multiple Airlines Logo
1:15 pm - 8:09 am
TYS
-
CLT
18h 54m
1 stop
$209Multiple Airlines
Fri, Apr 24 - Fri, May 1
Multiple Airlines Logo
4:33 pm - 5:30 pm
CLT
-
TYS
24h 57m
1 stop
Multiple Airlines Logo
9:32 pm - 9:10 am
TYS
-
CLT
11h 38m
1 stop
$211Multiple Airlines
Sun, Apr 12 - Thu, Apr 16
Multiple Airlines Logo
9:04 am - 2:50 pm
CLT
-
TYS
5h 46m
1 stop
Multiple Airlines Logo
9:25 pm - 9:10 am
TYS
-
CLT
11h 45m
1 stop
$213Multiple Airlines
Thu, Apr 30 - Thu, Apr 30
Multiple Airlines Logo
7:19 pm - 5:30 pm
CLT
-
TYS
22h 11m
1 stop
Multiple Airlines Logo
1:15 pm - 8:09 am
TYS
-
CLT
18h 54m
1 stop
$215Multiple Airlines
Sun, Apr 26 - Fri, May 1
Multiple Airlines Logo
9:54 pm - 2:50 pm
CLT
-
TYS
16h 56m
1 stop
Multiple Airlines Logo
9:25 pm - 9:10 am
TYS
-
CLT
11h 45m
1 stop
$217Multiple Airlines
Wed, Apr 29 - Thu, Apr 30
Southwest Logo
6:40 am - 12:00 pm
CHS
-
TYS
5h 20m
1 stop
Southwest Logo
8:15 am - 1:35 pm
TYS
-
CHS
5h 20m
1 stop
$221Southwest
Tue, May 5 - Tue, May 12
American Airlines Logo
5:00 am - 8:32 am
MYR
-
TYS
3h 32m
1 stop
American Airlines Logo
5:00 am - 8:23 am
TYS
-
MYR
3h 23m
1 stop
$221American Airlines
Wed, Apr 22 - Wed, Apr 29
Southwest Logo
12:00 pm - 8:50 pm
CHS
-
TYS
8h 50m
2 stops
Southwest Logo
8:15 am - 1:35 pm
TYS
-
CHS
5h 20m
1 stop
$226Southwest
Tue, May 5 - Tue, May 12
American Airlines Logo
5:44 pm - 10:12 pm
CHS
-
TYS
4h 28m
1 stop
American Airlines Logo
5:00 am - 8:31 am
TYS
-
CHS
3h 31m
1 stop
$264American Airlines
Tue, May 19 - Wed, May 20
Delta Logo
7:59 pm - 11:56 pm
SAV
-
TYS
3h 57m
1 stop
Delta Logo
5:40 am - 9:31 am
TYS
-
SAV
3h 51m
1 stop
$318Delta
Mon, May 25 - Wed, May 27

United Airlines flights from South Carolina to Knoxville

Our best United Airlines deals on South Carolina to Knoxville flight tickets
United Airlines
May 6
CHS6:00 amCharleston
8h 34m
1 stop
TYS2:34 pmKnoxville McGhee Tyson
May 9
TYS9:50 amKnoxville McGhee Tyson
24h 13m
1 stop
CHS10:03 amCharleston
$566
United Airlines
May 6
CHS6:00 amCharleston
14h 12m
1 stop
TYS8:12 pmKnoxville McGhee Tyson
May 9
TYS9:50 amKnoxville McGhee Tyson
9h 09m
1 stop
CHS6:59 pmCharleston
$587
United Airlines
Apr 12
SAV5:40 amSavannah/Hilton Head
9h 29m
1 stop
TYS3:09 pmKnoxville McGhee Tyson
Apr 17
TYS5:53 pmKnoxville McGhee Tyson
20h 47m
2 stops
SAV2:40 pmSavannah/Hilton Head
$718

Delta flights from South Carolina to Knoxville

Our best Delta deals on South Carolina to Knoxville flight tickets
Delta
May 25
SAV7:59 pmSavannah/Hilton Head
3h 57m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
May 27
TYS5:40 amKnoxville McGhee Tyson
3h 51m
1 stop
SAV9:31 amSavannah/Hilton Head
$318
Delta
Aug 25
SAV7:00 amSavannah/Hilton Head
4h 05m
1 stop
TYS11:05 amKnoxville McGhee Tyson
Sep 3
TYS5:30 amKnoxville McGhee Tyson
3h 47m
1 stop
SAV9:17 amSavannah/Hilton Head
$337
Delta
Apr 18
MYR6:11 pmMyrtle Beach Intl
5h 43m
1 stop
TYS11:54 pmKnoxville McGhee Tyson
Apr 19
TYS5:40 amKnoxville McGhee Tyson
4h 00m
1 stop
MYR9:40 amMyrtle Beach Intl
$338

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 29, 2026.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 4/24

9:54 pm-12:06 pm

1 stop14h 12m

Knoxville McGhee Tyson

Fri 5/1

1:15 pm-8:09 am

1 stop18h 54m

$209

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sun 4/12

4:33 pm-5:30 pm

1 stop24h 57m

Knoxville McGhee Tyson

Thu 4/16

9:32 pm-9:10 am

1 stop11h 38m

$211

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 4/30

9:04 am-2:50 pm

1 stop5h 46m

Knoxville McGhee Tyson

Thu 4/30

9:25 pm-9:10 am

1 stop11h 45m

$213

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sun 4/26

7:19 pm-5:30 pm

1 stop22h 11m

Knoxville McGhee Tyson

Fri 5/1

1:15 pm-8:09 am

1 stop18h 54m

$215

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Wed 4/29

9:54 pm-2:50 pm

1 stop16h 56m

Knoxville McGhee Tyson

Thu 4/30

9:25 pm-9:10 am

1 stop11h 45m

$217

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 5/5

6:40 am-12:00 pm

1 stop5h 20m

Knoxville McGhee Tyson

Tue 5/12

8:15 am-1:35 pm

1 stop5h 20m

$221
Quickest round-trip

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 4/22

5:00 am-8:32 am

1 stop3h 32m

Knoxville McGhee Tyson

Wed 4/29

5:00 am-8:23 am

1 stop3h 23m

$221

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 5/5

12:00 pm-8:50 pm

2 stops8h 50m

Knoxville McGhee Tyson

Tue 5/12

8:15 am-1:35 pm

1 stop5h 20m

$226

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 5/19

5:44 pm-10:12 pm

1 stop4h 28m

Knoxville McGhee Tyson

Wed 5/20

5:00 am-8:31 am

1 stop3h 31m

$264

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Mon 5/25

7:59 pm-11:56 pm

1 stop3h 57m

Knoxville McGhee Tyson

Wed 5/27

5:40 am-9:31 am

1 stop3h 51m

$318

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from South Carolina to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from South Carolina to Knoxville McGhee Tyson?

American Airlines, Delta, and Southwest are the most popular carriers operating from South Carolina to Knoxville McGhee Tyson

Cheap South Carolina to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Knoxville

Fastest flight time

3h 19m

Direct flights

Mon, Tue, Wed, Fri, Sat and Sun

Airports in Knoxville

1 airport
The fastest flight from South Carolina to Knoxville takes 3h 19m
Direct flights go from South Carolina to Knoxville on Monday, Tuesday, Wednesday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport in Knoxville. From South Carolina there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Knoxville McGhee Tyson Airport?

    Prices for flights from South Carolina to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from South Carolina to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from South Carolina to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from South Carolina to Knoxville

Compare and see reviews for airlines that fly from South Carolina to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $254Free CancellationRating
7.9
8,359 reviews
Search Delta flights
American AirlinesPriceFrom $278Free CancellationRating
7.1
11,521 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Carolina to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Carolina to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Knoxville?

Once you have performed a search for South Carolina to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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