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Cheap flights from South Carolina to Knoxville from $89

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Knoxville departing on 1/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:53 am - 4:59 pm
CLT
-
TYS
8h 06m1 stop
Multiple Airlines Logo
6:12 pm - 6:49 am
TYS
-
CLT
12h 37m1 stop
$211Multiple Airlines
Fri, Feb 20 - Sun, Feb 22
Allegiant Air Logo
7:00 am - 11:09 am
SAV
-
TYS
28h 09m1 stop
Allegiant Air Logo
9:29 am - 5:05 pm
TYS
-
SAV
7h 36m1 stop
$216Allegiant Air
Fri, Jan 9 - Sun, Jan 11
American Airlines Logo
6:23 pm - 11:59 pm
CHS
-
TYS
5h 36m1 stop
American Airlines Logo
7:11 pm - 11:07 pm
TYS
-
CHS
3h 56m1 stop
$271American Airlines
Sat, Jan 17 - Sun, Jan 18
American Airlines Logo
7:56 pm - 11:54 pm
MYR
-
TYS
3h 58m1 stop
American Airlines Logo
5:57 pm - 10:56 pm
TYS
-
MYR
4h 59m1 stop
$317American Airlines
Mon, Mar 2 - Wed, Mar 4
Delta Logo
10:31 am - 3:19 pm
CHS
-
TYS
4h 48m1 stop
Delta Logo
5:40 am - 9:26 am
TYS
-
CHS
3h 46m1 stop
$327Delta
Sat, Jan 24 - Sun, Jan 25
Southwest Logo
4:30 pm - 10:10 pm
CHS
-
TYS
5h 40m1 stop
Southwest Logo
7:40 am - 1:25 pm
TYS
-
CHS
5h 45m1 stop
$332Southwest
Thu, Mar 26 - Sun, Mar 29
Delta Logo
5:27 am - 11:08 am
CHS
-
TYS
5h 41m1 stop
Delta Logo
5:30 am - 9:23 am
TYS
-
CHS
3h 53m1 stop
$337Delta
Sat, Feb 14 - Fri, Feb 20
Southwest Logo
3:35 pm - 9:15 pm
MYR
-
TYS
5h 40m1 stop
Southwest Logo
6:35 am - 1:30 pm
TYS
-
MYR
6h 55m1 stop
$337Southwest
Thu, Mar 26 - Sun, Mar 29
United Airlines Logo
3:00 pm - 10:08 am
HHH
-
TYS
19h 08m1 stop
United Airlines Logo
4:18 pm - 2:01 pm
TYS
-
HHH
21h 43m2 stops
$746United Airlines
Mon, Apr 13 - Fri, Apr 17
United Airlines Logo
3:00 pm - 7:34 pm
HHH
-
TYS
28h 34m2 stops
United Airlines Logo
4:18 pm - 2:01 pm
TYS
-
HHH
21h 43m2 stops
$758United Airlines
Mon, Apr 13 - Fri, Apr 17

Allegiant Air flights from South Carolina to Knoxville

Our best Allegiant Air deals on South Carolina to Knoxville flight tickets
Allegiant Air
Jan 9
SAV7:00 amSavannah/Hilton Head
28h 09m
1 stop
TYS11:09 amKnoxville McGhee Tyson
Jan 11
TYS9:29 amKnoxville McGhee Tyson
7h 36m
1 stop
SAV5:05 pmSavannah/Hilton Head
$219
Find similar
Allegiant Air
Dec 24
SAV9:15 amSavannah/Hilton Head
7h 26m
1 stop
TYS4:41 pmKnoxville McGhee Tyson
Dec 29
TYS9:20 pmKnoxville McGhee Tyson
16h 22m
1 stop
SAV1:42 pmSavannah/Hilton Head
$310
Find similar
Allegiant Air
Dec 27
SAV7:00 amSavannah/Hilton Head
11h 37m
1 stop
TYS6:37 pmKnoxville McGhee Tyson
Dec 31
TYS11:08 amKnoxville McGhee Tyson
4h 49m
1 stop
SAV3:57 pmSavannah/Hilton Head
$317
Find similar

American Airlines flights from South Carolina to Knoxville

Our best American Airlines deals on South Carolina to Knoxville flight tickets
American Airlines
Mar 2
MYR7:56 pmMyrtle Beach Intl
3h 58m
1 stop
TYS11:54 pmKnoxville McGhee Tyson
Mar 4
TYS5:57 pmKnoxville McGhee Tyson
4h 59m
1 stop
MYR10:56 pmMyrtle Beach Intl
$317
Find similar
American Airlines
Feb 14
CHS2:55 pmCharleston
5h 34m
1 stop
TYS8:29 pmKnoxville McGhee Tyson
Feb 20
TYS5:57 pmKnoxville McGhee Tyson
6h 02m
1 stop
CHS11:59 pmCharleston
$347
Find similar
American Airlines
Jan 9
CLT9:34 amCharlotte Douglas
12h 10m
1 stop
TYS9:44 pmKnoxville McGhee Tyson
Jan 16
TYS1:36 pmKnoxville McGhee Tyson
17h 55m
1 stop
CLT7:31 amCharlotte Douglas
$367
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 13, 2025.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 2/20

8:53 am-4:59 pm

1 stop8h 06m

Knoxville McGhee Tyson

Sun 2/22

6:12 pm-6:49 am

1 stop12h 37m

$211

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Fri 1/9

7:00 am-11:09 am

1 stop28h 09m

Knoxville McGhee Tyson

Sun 1/11

9:29 am-5:05 pm

1 stop7h 36m

$216

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 1/17

6:23 pm-11:59 pm

1 stop5h 36m

Knoxville McGhee Tyson

Sun 1/18

7:11 pm-11:07 pm

1 stop3h 56m

$271

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 3/2

7:56 pm-11:54 pm

1 stop3h 58m

Knoxville McGhee Tyson

Wed 3/4

5:57 pm-10:56 pm

1 stop4h 59m

$317

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 1/24

10:31 am-3:19 pm

1 stop4h 48m

Knoxville McGhee Tyson

Sun 1/25

5:40 am-9:26 am

1 stop3h 46m

$327

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 3/26

4:30 pm-10:10 pm

1 stop5h 40m

Knoxville McGhee Tyson

Sun 3/29

7:40 am-1:25 pm

1 stop5h 45m

$332

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Sat 2/14

5:27 am-11:08 am

1 stop5h 41m

Knoxville McGhee Tyson

Fri 2/20

5:30 am-9:23 am

1 stop3h 53m

$337

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 3/26

3:35 pm-9:15 pm

1 stop5h 40m

Knoxville McGhee Tyson

Sun 3/29

6:35 am-1:30 pm

1 stop6h 55m

$337

Hilton Head IslandKnoxville

HHH - TYS

HHHTYS

Hilton Head Island

Mon 4/13

3:00 pm-10:08 am

1 stop19h 08m

Knoxville McGhee Tyson

Fri 4/17

4:18 pm-2:01 pm

2 stops21h 43m

$746

Hilton Head IslandKnoxville

HHH - TYS

HHHTYS

Hilton Head Island

Mon 4/13

3:00 pm-7:34 pm

2 stops28h 34m

Knoxville McGhee Tyson

Fri 4/17

4:18 pm-2:01 pm

2 stops21h 43m

$758

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from South Carolina to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from South Carolina to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $464. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from South Carolina to Knoxville for around $780.

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from South Carolina to Knoxville when you can find flight prices for as low as $525. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $696.

Cheap South Carolina to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Knoxville

Fastest flight time

1h 05m

Direct flights

Mon, Wed, Sat and Sun

Airports in Knoxville

1 airport
The fastest flight from South Carolina to Knoxville takes 1h 05m
Direct flights go from South Carolina to Knoxville on Monday, Wednesday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport in Knoxville. From South Carolina there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Knoxville McGhee Tyson Airport?

    Prices for flights from South Carolina to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from South Carolina to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from South Carolina to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from South Carolina to Knoxville

Compare and see reviews for airlines that fly from South Carolina to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $228Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights
DeltaPriceFrom $326Free CancellationRating
7.9
8,007 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Carolina to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Carolina to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Knoxville?

Once you have performed a search for South Carolina to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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