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Cheap flights from South Carolina to Knoxville from $85

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Knoxville departing on 3/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:46 pm - 6:26 pm
CLT
-
TYS
27h 40m
1 stop
Multiple Airlines Logo
6:24 pm - 8:03 am
TYS
-
CLT
13h 39m
1 stop
$179Multiple Airlines
Tue, Mar 3 - Tue, Mar 10
Multiple Airlines Logo
2:46 pm - 6:26 pm
CLT
-
TYS
27h 40m
1 stop
Multiple Airlines Logo
4:05 pm - 11:56 pm
TYS
-
CLT
7h 51m
1 stop
$204Multiple Airlines
Tue, Mar 3 - Tue, Mar 10
Multiple Airlines Logo
5:54 pm - 6:26 pm
CLT
-
TYS
24h 32m
2 stops
Multiple Airlines Logo
6:24 pm - 8:03 am
TYS
-
CLT
13h 39m
1 stop
$211Multiple Airlines
Tue, Mar 3 - Tue, Mar 10
Multiple Airlines Logo
11:12 am - 6:26 pm
CLT
-
TYS
7h 14m
1 stop
Multiple Airlines Logo
4:25 pm - 11:56 pm
TYS
-
CLT
7h 31m
1 stop
$218Multiple Airlines
Wed, Mar 4 - Wed, Mar 11
Delta Logo
6:26 pm - 11:57 pm
SAV
-
TYS
5h 31m
1 stop
Delta Logo
5:40 am - 9:16 am
TYS
-
SAV
3h 36m
1 stop
$281Delta
Wed, Apr 8 - Thu, Apr 9
Southwest Logo
6:40 am - 12:00 pm
SAV
-
TYS
5h 20m
1 stop
Southwest Logo
6:35 am - 9:20 pm
TYS
-
SAV
14h 45m
2 stops
$283Southwest
Wed, Apr 8 - Thu, Apr 9
Southwest Logo
8:05 am - 7:40 pm
SAV
-
TYS
11h 35m
2 stops
Southwest Logo
6:35 am - 9:20 pm
TYS
-
SAV
14h 45m
2 stops
$288Southwest
Wed, Apr 8 - Thu, Apr 9
Delta Logo
10:55 am - 3:06 pm
MYR
-
TYS
4h 11m
1 stop
Delta Logo
5:30 am - 10:09 am
TYS
-
MYR
4h 39m
1 stop
$317Delta
Fri, Jul 3 - Tue, Jul 7
American Airlines Logo
5:04 pm - 10:24 pm
HHH
-
TYS
5h 20m
1 stop
American Airlines Logo
6:54 am - 10:32 am
TYS
-
HHH
3h 38m
1 stop
$448American Airlines
Mon, Apr 13 - Fri, Apr 17
American Airlines Logo
5:19 pm - 9:05 pm
HHH
-
TYS
3h 46m
1 stop
American Airlines Logo
7:02 am - 11:53 am
TYS
-
HHH
4h 51m
1 stop
$457American Airlines
Tue, Mar 3 - Tue, Mar 10

Delta flights from South Carolina to Knoxville

Our best Delta deals on South Carolina to Knoxville flight tickets
Delta
Apr 8
SAV6:26 pmSavannah/Hilton Head
5h 31m
1 stop
TYS11:57 pmKnoxville McGhee Tyson
Apr 9
TYS5:40 amKnoxville McGhee Tyson
3h 36m
1 stop
SAV9:16 amSavannah/Hilton Head
$281
Delta
Jul 3
MYR10:55 amMyrtle Beach Intl
4h 11m
1 stop
TYS3:06 pmKnoxville McGhee Tyson
Jul 7
TYS5:30 amKnoxville McGhee Tyson
4h 39m
1 stop
MYR10:09 amMyrtle Beach Intl
$317
Delta
Mar 4
SAV5:30 amSavannah/Hilton Head
3h 34m
1 stop
TYS9:04 amKnoxville McGhee Tyson
Mar 11
TYS5:40 amKnoxville McGhee Tyson
3h 36m
1 stop
SAV9:16 amSavannah/Hilton Head
$327

Southwest flights from South Carolina to Knoxville

Our best Southwest deals on South Carolina to Knoxville flight tickets
Southwest
Apr 8
SAV6:40 amSavannah/Hilton Head
5h 20m
1 stop
TYS12:00 pmKnoxville McGhee Tyson
Apr 9
TYS6:35 amKnoxville McGhee Tyson
14h 45m
2 stops
SAV9:20 pmSavannah/Hilton Head
$283
Southwest
Apr 8
SAV8:05 amSavannah/Hilton Head
11h 35m
2 stops
TYS7:40 pmKnoxville McGhee Tyson
Apr 9
TYS6:35 amKnoxville McGhee Tyson
14h 45m
2 stops
SAV9:20 pmSavannah/Hilton Head
$288
Southwest
Apr 10
CLT4:20 pmCharlotte Douglas
4h 55m
1 stop
TYS9:15 pmKnoxville McGhee Tyson
Apr 11
TYS5:40 pmKnoxville McGhee Tyson
3h 35m
1 stop
CLT9:15 pmCharlotte Douglas
$290

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 3/3

2:46 pm-6:26 pm

1 stop27h 40m

Knoxville McGhee Tyson

Tue 3/10

6:24 pm-8:03 am

1 stop13h 39m

$179

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 3/3

2:46 pm-6:26 pm

1 stop27h 40m

Knoxville McGhee Tyson

Tue 3/10

4:05 pm-11:56 pm

1 stop7h 51m

$204

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 3/3

5:54 pm-6:26 pm

2 stops24h 32m

Knoxville McGhee Tyson

Tue 3/10

6:24 pm-8:03 am

1 stop13h 39m

$211

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Wed 3/4

11:12 am-6:26 pm

1 stop7h 14m

Knoxville McGhee Tyson

Wed 3/11

4:25 pm-11:56 pm

1 stop7h 31m

$218

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Wed 4/8

6:26 pm-11:57 pm

1 stop5h 31m

Knoxville McGhee Tyson

Thu 4/9

5:40 am-9:16 am

1 stop3h 36m

$281

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Wed 4/8

6:40 am-12:00 pm

1 stop5h 20m

Knoxville McGhee Tyson

Thu 4/9

6:35 am-9:20 pm

2 stops14h 45m

$283

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Wed 4/8

8:05 am-7:40 pm

2 stops11h 35m

Knoxville McGhee Tyson

Thu 4/9

6:35 am-9:20 pm

2 stops14h 45m

$288

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 7/3

10:55 am-3:06 pm

1 stop4h 11m

Knoxville McGhee Tyson

Tue 7/7

5:30 am-10:09 am

1 stop4h 39m

$317

Hilton Head IslandKnoxville

HHH - TYS

HHHTYS

Hilton Head Island

Mon 4/13

5:04 pm-10:24 pm

1 stop5h 20m

Knoxville McGhee Tyson

Fri 4/17

6:54 am-10:32 am

1 stop3h 38m

$448

Hilton Head IslandKnoxville

HHH - TYS

HHHTYS

Hilton Head Island

Tue 3/3

5:19 pm-9:05 pm

1 stop3h 46m

Knoxville McGhee Tyson

Tue 3/10

7:02 am-11:53 am

1 stop4h 51m

$457

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from South Carolina to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from South Carolina to Knoxville McGhee Tyson?

Southwest, Delta, and American Airlines are the most popular carriers operating from South Carolina to Knoxville McGhee Tyson

Cheap South Carolina to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Knoxville

Fastest flight time

1h 14m

Direct flights

Mon, Tue, Wed, Thu and Sat

Airports in Knoxville

1 airport
The fastest flight from South Carolina to Knoxville takes 1h 14m
Direct flights go from South Carolina to Knoxville on Monday, Tuesday, Wednesday, Thursday and Saturday. There are no airlines offering direct flights.
There is 1 airport in Knoxville. From South Carolina there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Knoxville McGhee Tyson Airport?

    Prices for flights from South Carolina to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from South Carolina to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from South Carolina to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from South Carolina to Knoxville

Compare and see reviews for airlines that fly from South Carolina to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $254Free CancellationRating
7.9
8,144 reviews
Search Delta flights
American AirlinesPriceFrom $278Free CancellationRating
7.2
11,222 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Carolina to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Carolina to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Knoxville?

Once you have performed a search for South Carolina to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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