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Cheap flights from South Carolina to Knoxville from $93

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Knoxville departing on 11/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Knoxville

Cheap round-trip flights

Logo
10:11 am - 10:33 amCHS-TYS
24h 22m1 stop
Logo
9:15 pm - 9:06 amTYS-CHS
11h 51m1 stop
$226
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Mon, Oct 20 - Thu, Oct 23
Logo
2:32 pm - 11:55 amCLT-TYS
21h 23m1 stop
Logo
11:23 am - 9:59 pmTYS-CLT
10h 36m1 stop
$231
Find Deal
Tue, Sep 30 - Tue, Oct 7
Delta Logo
6:58 pm - 11:46 pmMYR-TYS
4h 48m1 stop
Delta Logo
5:44 am - 9:51 amTYS-MYR
4h 07m1 stop
$317Delta
Find Deal
Mon, Oct 20 - Wed, Oct 22
Delta Logo
9:00 am - 2:46 pmCHS-TYS
5h 46m1 stop
Delta Logo
5:25 am - 9:31 amTYS-CHS
4h 06m1 stop
$327Delta
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Fri, Nov 21 - Sun, Nov 23
American Airlines Logo
1:01 pm - 4:49 pmSAV-TYS
3h 48m1 stop
American Airlines Logo
8:37 pm - 11:59 pmTYS-SAV
3h 22m1 stop
$327American Airlines
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Fri, Oct 3 - Mon, Oct 6
American Airlines Logo
6:00 am - 11:29 amMYR-TYS
5h 29m1 stop
American Airlines Logo
8:37 pm - 11:59 pmTYS-MYR
3h 22m1 stop
$337American Airlines
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Wed, Oct 8 - Fri, Oct 10
Allegiant Air Logo
6:00 am - 2:50 pmSAV-TYS
8h 50m1 stop
Allegiant Air Logo
9:35 pm - 11:38 pmTYS-SAV
26h 03m2 stops
$342Allegiant Air
Find Deal
Fri, Oct 3 - Sun, Oct 5
Allegiant Air Logo
9:00 am - 10:03 pmSAV-TYS
13h 03m1 stop
Allegiant Air Logo
9:31 pm - 11:36 pmTYS-SAV
26h 05m1 stop
$418Allegiant Air
Find Deal
Thu, Nov 20 - Sun, Nov 30
United Airlines Logo
4:45 pm - 10:45 pmMYR-TYS
6h 00m1 stop
United Airlines Logo
7:00 am - 2:42 pmTYS-MYR
7h 42m1 stop
$447United Airlines
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Tue, Sep 16 - Sat, Sep 20
United Airlines Logo
4:45 pm - 10:45 pmMYR-TYS
6h 00m1 stop
United Airlines Logo
7:00 am - 4:27 pmTYS-MYR
9h 27m2 stops
$466United Airlines
Find Deal
Tue, Sep 16 - Sat, Sep 20

American Airlines flights from South Carolina to Knoxville

Our best American Airlines deals on South Carolina to Knoxville flight tickets
American Airlines
Oct 3
SAV1:01 pmSavannah/Hilton Head
3h 48m
1 stop
TYS4:49 pmKnoxville McGhee Tyson
Oct 6
TYS8:37 pmKnoxville McGhee Tyson
3h 22m
1 stop
SAV11:59 pmSavannah/Hilton Head
$327
Find similar
American Airlines
Oct 8
MYR6:00 amMyrtle Beach Intl
5h 29m
1 stop
TYS11:29 amKnoxville McGhee Tyson
Oct 10
TYS8:37 pmKnoxville McGhee Tyson
3h 22m
1 stop
MYR11:59 pmMyrtle Beach Intl
$337
Find similar
American Airlines
Oct 4
CLT9:41 pmCharlotte Douglas
15h 28m
1 stop
TYS1:09 pmKnoxville McGhee Tyson
Oct 5
TYS4:28 pmKnoxville McGhee Tyson
1h 25m
CLT5:53 pmCharlotte Douglas
$342
Find similar

Allegiant Air flights from South Carolina to Knoxville

Our best Allegiant Air deals on South Carolina to Knoxville flight tickets
Allegiant Air
Oct 3
SAV6:00 amSavannah/Hilton Head
8h 50m
1 stop
TYS2:50 pmKnoxville McGhee Tyson
Oct 5
TYS9:35 pmKnoxville McGhee Tyson
26h 03m
2 stops
SAV11:38 pmSavannah/Hilton Head
$342
Find similar
Allegiant Air
Nov 20
SAV9:00 amSavannah/Hilton Head
13h 03m
1 stop
TYS10:03 pmKnoxville McGhee Tyson
Nov 30
TYS9:31 pmKnoxville McGhee Tyson
26h 05m
1 stop
SAV11:36 pmSavannah/Hilton Head
$418
Find similar
Allegiant Air
Nov 20
SAV9:00 amSavannah/Hilton Head
13h 03m
1 stop
TYS10:03 pmKnoxville McGhee Tyson
Nov 30
TYS9:31 pmKnoxville McGhee Tyson
26h 05m
1 stop
SAV11:36 pmSavannah/Hilton Head
$433
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 3, 2025.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Mon 10/20

10:11 am-10:33 am

1 stop24h 22m

Knoxville McGhee Tyson

Thu 10/23

9:15 pm-9:06 am

1 stop11h 51m

$226

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 9/30

2:32 pm-11:55 am

1 stop21h 23m

Knoxville McGhee Tyson

Tue 10/7

11:23 am-9:59 pm

1 stop10h 36m

$231

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 10/20

6:58 pm-11:46 pm

1 stop4h 48m

Knoxville McGhee Tyson

Wed 10/22

5:44 am-9:51 am

1 stop4h 07m

$317

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 11/21

9:00 am-2:46 pm

1 stop5h 46m

Knoxville McGhee Tyson

Sun 11/23

5:25 am-9:31 am

1 stop4h 06m

$327

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Fri 10/3

1:01 pm-4:49 pm

1 stop3h 48m

Knoxville McGhee Tyson

Mon 10/6

8:37 pm-11:59 pm

1 stop3h 22m

$327

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 10/8

6:00 am-11:29 am

1 stop5h 29m

Knoxville McGhee Tyson

Fri 10/10

8:37 pm-11:59 pm

1 stop3h 22m

$337

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Fri 10/3

6:00 am-2:50 pm

1 stop8h 50m

Knoxville McGhee Tyson

Sun 10/5

9:35 pm-11:38 pm

2 stops26h 03m

$342

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Thu 11/20

9:00 am-10:03 pm

1 stop13h 03m

Knoxville McGhee Tyson

Sun 11/30

9:31 pm-11:36 pm

1 stop26h 05m

$418

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 9/16

4:45 pm-10:45 pm

1 stop6h 00m

Knoxville McGhee Tyson

Sat 9/20

7:00 am-2:42 pm

1 stop7h 42m

$447

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 9/16

4:45 pm-10:45 pm

1 stop6h 00m

Knoxville McGhee Tyson

Sat 9/20

7:00 am-4:27 pm

2 stops9h 27m

$466

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from South Carolina to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of June is, on average, the cheapest month to fly to Knoxville from South Carolina, with most prices found around $356. If you aren’t able to travel during the month of June, then book flights to Knoxville from South Carolina during July instead. Flights to Knoxville in July, while not as cheap as those in June, still average around $366.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from South Carolina to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $464. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from South Carolina to Knoxville for around $780.

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from South Carolina to Knoxville when you can find flight prices for as low as $525. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $696.

Cheap South Carolina to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Knoxville

Fastest flight time

1h 05m

Direct flights

Mon, Tue, Wed, Fri and Sat

Airports in Knoxville

1 airport
The fastest flight from South Carolina to Knoxville takes 1h 05m
Direct flights go from South Carolina to Knoxville on Monday, Tuesday, Wednesday, Friday and Saturday. There are no airlines offering direct flights.
There is 1 airport near Knoxville: Knoxville McGhee Tyson (TYS)
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Knoxville McGhee Tyson Airport?

    Prices for flights from South Carolina to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from South Carolina to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from South Carolina to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from South Carolina to Knoxville

Compare and see reviews for airlines that fly from South Carolina to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $198Free CancellationRating
7.9
7,972 reviews
Search Delta flights
American AirlinesPriceFrom $228Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Alcoa
Lenoir City
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Carolina to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Carolina to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Knoxville?

Once you have performed a search for South Carolina to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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