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Cheap flights from South Carolina to Knoxville from $74

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Knoxville departing on 7/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from South Carolina to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:30 am - 9:36 am
CLT
-
TYS
4h 06m
1 stop
Delta Logo
5:57 pm - 9:38 pm
TYS
-
CLT
3h 41m
1 stop
$147Delta
Fri, Jul 10 - Mon, Aug 31
Delta Logo
9:42 am - 2:49 pm
CLT
-
TYS
5h 07m
1 stop
Delta Logo
3:54 pm - 10:00 pm
TYS
-
CLT
6h 06m
1 stop
$162Delta
Tue, Jun 9 - Tue, Jun 16
Multiple Airlines Logo
2:53 pm - 11:06 pm
CHS
-
TYS
8h 13m
1 stop
Multiple Airlines Logo
6:00 am - 8:38 am
TYS
-
CHS
26h 38m
1 stop
$277Multiple Airlines
Thu, May 28 - Sat, May 30
Multiple Airlines Logo
6:41 pm - 8:32 am
CLT
-
TYS
13h 51m
1 stop
Multiple Airlines Logo
2:49 pm - 10:31 am
TYS
-
CLT
43h 42m
2 stops
$281Multiple Airlines
Fri, Jul 10 - Mon, Aug 31
American Airlines Logo
11:01 am - 9:31 pm
CHS
-
TYS
10h 30m
1 stop
American Airlines Logo
7:32 am - 3:43 pm
TYS
-
CHS
8h 11m
1 stop
$293American Airlines
Tue, Jun 9 - Tue, Jun 16
Southwest Logo
1:45 pm - 8:50 pm
CLT
-
TYS
7h 05m
1 stop
Southwest Logo
6:55 pm - 10:05 pm
TYS
-
CLT
3h 10m
1 stop
$295Southwest
Wed, Jun 3 - Wed, Jun 10
Southwest Logo
3:00 pm - 9:15 pm
CHS
-
TYS
6h 15m
1 stop
Southwest Logo
8:10 am - 8:25 pm
TYS
-
CHS
12h 15m
2 stops
$300Southwest
Tue, Jun 9 - Tue, Jun 16
American Airlines Logo
5:15 am - 10:36 am
SAV
-
TYS
5h 21m
1 stop
American Airlines Logo
7:59 pm - 11:59 pm
TYS
-
SAV
4h 00m
1 stop
$308American Airlines
Wed, Jun 3 - Thu, Jun 4
United Airlines Logo
2:48 pm - 9:48 am
HHH
-
TYS
19h 00m
1 stop
United Airlines Logo
6:02 pm - 2:03 pm
TYS
-
HHH
20h 01m
1 stop
$672United Airlines
Wed, Aug 19 - Sat, Aug 22
United Airlines Logo
2:48 pm - 3:54 pm
HHH
-
TYS
25h 06m
2 stops
United Airlines Logo
6:02 pm - 2:03 pm
TYS
-
HHH
20h 01m
1 stop
$708United Airlines
Wed, Aug 19 - Sat, Aug 22

Delta flights from South Carolina to Knoxville

Our best Delta deals on South Carolina to Knoxville flight tickets
Delta
Jul 10
CLT5:30 amCharlotte Douglas
4h 06m
1 stop
TYS9:36 amKnoxville McGhee Tyson
Aug 31
TYS5:57 pmKnoxville McGhee Tyson
3h 41m
1 stop
CLT9:38 pmCharlotte Douglas
$147
Delta
Jun 9
CLT9:42 amCharlotte Douglas
5h 07m
1 stop
TYS2:49 pmKnoxville McGhee Tyson
Jun 16
TYS3:54 pmKnoxville McGhee Tyson
6h 06m
1 stop
CLT10:00 pmCharlotte Douglas
$162
Delta
Jun 12
CLT9:42 amCharlotte Douglas
3h 37m
1 stop
TYS1:19 pmKnoxville McGhee Tyson
Jun 14
TYS5:40 amKnoxville McGhee Tyson
3h 13m
1 stop
CLT8:53 amCharlotte Douglas
$187

American Airlines flights from South Carolina to Knoxville

Our best American Airlines deals on South Carolina to Knoxville flight tickets
American Airlines
Jun 9
CHS11:01 amCharleston
10h 30m
1 stop
TYS9:31 pmKnoxville McGhee Tyson
Jun 16
TYS7:32 amKnoxville McGhee Tyson
8h 11m
1 stop
CHS3:43 pmCharleston
$293
American Airlines
Jun 3
SAV5:15 amSavannah/Hilton Head
5h 21m
1 stop
TYS10:36 amKnoxville McGhee Tyson
Jun 4
TYS7:59 pmKnoxville McGhee Tyson
4h 00m
1 stop
SAV11:59 pmSavannah/Hilton Head
$308
American Airlines
Jun 14
MYR8:41 pmMyrtle Beach Intl
3h 06m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
Jun 16
TYS5:00 amKnoxville McGhee Tyson
3h 44m
1 stop
MYR8:44 amMyrtle Beach Intl
$316

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 13, 2026.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 7/10

5:30 am-9:36 am

1 stop4h 06m

Knoxville McGhee Tyson

Mon 8/31

5:57 pm-9:38 pm

1 stop3h 41m

$147

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 6/9

9:42 am-2:49 pm

1 stop5h 07m

Knoxville McGhee Tyson

Tue 6/16

3:54 pm-10:00 pm

1 stop6h 06m

$162

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 5/28

2:53 pm-11:06 pm

1 stop8h 13m

Knoxville McGhee Tyson

Sat 5/30

6:00 am-8:38 am

1 stop26h 38m

$277

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 7/10

6:41 pm-8:32 am

1 stop13h 51m

Knoxville McGhee Tyson

Mon 8/31

2:49 pm-10:31 am

2 stops43h 42m

$281

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 6/9

11:01 am-9:31 pm

1 stop10h 30m

Knoxville McGhee Tyson

Tue 6/16

7:32 am-3:43 pm

1 stop8h 11m

$293

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Wed 6/3

1:45 pm-8:50 pm

1 stop7h 05m

Knoxville McGhee Tyson

Wed 6/10

6:55 pm-10:05 pm

1 stop3h 10m

$295

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 6/9

3:00 pm-9:15 pm

1 stop6h 15m

Knoxville McGhee Tyson

Tue 6/16

8:10 am-8:25 pm

2 stops12h 15m

$300

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Wed 6/3

5:15 am-10:36 am

1 stop5h 21m

Knoxville McGhee Tyson

Thu 6/4

7:59 pm-11:59 pm

1 stop4h 00m

$308

Hilton Head IslandKnoxville

HHH - TYS

HHHTYS

Hilton Head Island

Wed 8/19

2:48 pm-9:48 am

1 stop19h 00m

Knoxville McGhee Tyson

Sat 8/22

6:02 pm-2:03 pm

1 stop20h 01m

$672

Hilton Head IslandKnoxville

HHH - TYS

HHHTYS

Hilton Head Island

Wed 8/19

2:48 pm-3:54 pm

2 stops25h 06m

Knoxville McGhee Tyson

Sat 8/22

6:02 pm-2:03 pm

1 stop20h 01m

$708

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from South Carolina to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from South Carolina, with most prices found around $228. If you aren’t able to travel during the month of September, then book flights to Knoxville from South Carolina during January instead. Flights to Knoxville in January, while not as cheap as those in September, still average around $254.

Cheap South Carolina to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Knoxville

Fastest flight time

1h 14m

Direct flights

Every day

Airports in Knoxville

1 airport
The fastest flight from South Carolina to Knoxville takes 1h 14m
Direct flights go from South Carolina to Knoxville every day.
There is 1 airport in Knoxville. From South Carolina there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

Frequently asked questions about flying from South Carolina to Knoxville

  • When did momondo last update prices for flights from South Carolina to Knoxville McGhee Tyson Airport?

    Prices for flights from South Carolina to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from South Carolina to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from South Carolina to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from South Carolina to Knoxville

Compare and see reviews for airlines that fly from South Carolina to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $254Free CancellationRating
7.9
8,453 reviews
Search Delta flights
American AirlinesPriceFrom $283Free CancellationRating
7.1
11,664 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Carolina to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Carolina to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Knoxville?

Once you have performed a search for South Carolina to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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