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Cheap flights from South Carolina to Knoxville from $102

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Knoxville departing on 9/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from South Carolina to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:20 am - 9:44 amCHS  Charleston-TYS Knoxville McGhee Tyson
3h 24m1 stop Charlotte Douglas
American Airlines Logo
6:15 am - 9:47 amTYS  Knoxville McGhee Tyson-CHS Charleston
3h 32m1 stop Charlotte Douglas
$227American Airlines
Wed, Sep 9 - Wed, Sep 16
Southwest Logo
6:45 am - 12:05 pmSAV  Savannah/Hilton Head-TYS Knoxville McGhee Tyson
5h 20m1 stop Nashville Intl
Southwest Logo
6:10 pm - 9:35 pmTYS  Knoxville McGhee Tyson-SAV Savannah/Hilton Head
3h 25m1 stop Nashville Intl
$231Southwest
Tue, Sep 1 - Sun, Sep 6
Southwest Logo
6:50 am - 12:20 pmSAV  Savannah/Hilton Head-TYS Knoxville McGhee Tyson
5h 30m1 stop Nashville Intl
Southwest Logo
6:10 pm - 9:35 pmTYS  Knoxville McGhee Tyson-SAV Savannah/Hilton Head
3h 25m1 stop Nashville Intl
$231Southwest
Mon, Aug 31 - Sun, Sep 6
Multiple Airlines Logo
9:44 pm - 9:40 amCHS  Charleston-TYS Knoxville McGhee Tyson
11h 56m1 stop Tampa
Multiple Airlines Logo
10:54 am - 8:38 amTYS  Knoxville McGhee Tyson-CHS Charleston
21h 44m1 stop Orlando Sanford Intl
$232Multiple Airlines
Mon, Aug 24 - Wed, Aug 26
American Airlines Logo
7:48 pm - 10:58 pmCHS  Charleston-TYS Knoxville McGhee Tyson
3h 10m1 stop Charlotte Douglas
American Airlines Logo
6:15 am - 9:47 amTYS  Knoxville McGhee Tyson-CHS Charleston
3h 32m1 stop Charlotte Douglas
$239American Airlines
Tue, Sep 8 - Tue, Sep 15
Delta Logo
5:30 am - 10:54 amSAV  Savannah/Hilton Head-TYS Knoxville McGhee Tyson
5h 24m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:23 pm - 11:57 pmTYS  Knoxville McGhee Tyson-SAV Savannah/Hilton Head
5h 34m1 stop Atlanta Hartsfield-Jackson
$269Delta
Wed, Oct 14 - Wed, Oct 14
American Airlines Logo
7:04 pm - 11:55 pmCHS  Charleston-TYS Knoxville McGhee Tyson
4h 51m1 stop Charlotte Douglas
American Airlines Logo
7:58 pm - 12:05 amTYS  Knoxville McGhee Tyson-CHS Charleston
4h 07m1 stop Charlotte Douglas
$269American Airlines
Mon, Oct 19 - Sat, Oct 24
American Airlines Logo
5:00 am - 10:30 amSAV  Savannah/Hilton Head-TYS Knoxville McGhee Tyson
5h 30m1 stop Charlotte Douglas
American Airlines Logo
8:13 pm - 12:03 amTYS  Knoxville McGhee Tyson-SAV Savannah/Hilton Head
3h 50m1 stop Charlotte Douglas
$272American Airlines
Fri, Dec 11 - Mon, Dec 14
Delta Logo
12:45 pm - 6:26 pmSAV  Savannah/Hilton Head-TYS Knoxville McGhee Tyson
5h 41m1 stop Atlanta Hartsfield-Jackson
Delta Logo
4:03 pm - 7:05 pmTYS  Knoxville McGhee Tyson-SAV Savannah/Hilton Head
3h 02m1 stop Atlanta Hartsfield-Jackson
$279Delta
Fri, Dec 11 - Mon, Dec 14
Delta Logo
5:30 am - 9:50 amSAV  Savannah/Hilton Head-TYS Knoxville McGhee Tyson
4h 20m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:21 pm - 11:58 pmTYS  Knoxville McGhee Tyson-SAV Savannah/Hilton Head
4h 37m1 stop Atlanta Hartsfield-Jackson
$307Delta
Thu, Dec 10 - Sun, Dec 13

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Southwest flights from South Carolina to Knoxville

Our best Southwest deals on South Carolina to Knoxville flight tickets
Southwest
Aug 31
SAV6:50 amSavannah/Hilton Head
5h 30m
1 stop
TYS12:20 pmKnoxville McGhee Tyson
Sep 6
TYS6:10 pmKnoxville McGhee Tyson
3h 25m
1 stop
SAV9:35 pmSavannah/Hilton Head
$231
Southwest
Sep 1
SAV8:00 amSavannah/Hilton Head
10h 55m
2 stops
TYS6:55 pmKnoxville McGhee Tyson
Sep 6
TYS6:10 pmKnoxville McGhee Tyson
3h 25m
1 stop
SAV9:35 pmSavannah/Hilton Head
$236
Southwest
Aug 31
SAV6:50 amSavannah/Hilton Head
13h 05m
2 stops
TYS7:55 pmKnoxville McGhee Tyson
Sep 6
TYS6:10 pmKnoxville McGhee Tyson
3h 25m
1 stop
SAV9:35 pmSavannah/Hilton Head
$242

American Airlines flights from South Carolina to Knoxville

Our best American Airlines deals on South Carolina to Knoxville flight tickets
American Airlines
Sep 9
CHS6:20 amCharleston
3h 24m
1 stop
TYS9:44 amKnoxville McGhee Tyson
Sep 16
TYS6:15 amKnoxville McGhee Tyson
3h 32m
1 stop
CHS9:47 amCharleston
$227
American Airlines
Sep 8
CHS7:48 pmCharleston
3h 10m
1 stop
TYS10:58 pmKnoxville McGhee Tyson
Sep 15
TYS6:15 amKnoxville McGhee Tyson
3h 32m
1 stop
CHS9:47 amCharleston
$239
American Airlines
Oct 19
CHS7:04 pmCharleston
4h 51m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
Oct 24
TYS7:58 pmKnoxville McGhee Tyson
4h 07m
1 stop
CHS12:05 amCharleston
$269

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonKnoxville

CHS Charleston - TYS Knoxville McGhee Tyson

CHSTYS

Charleston

Wed 9/9

6:20 am-9:44 am

1 stop3h 24m

Knoxville McGhee Tyson

Wed 9/16

6:15 am-9:47 am

1 stop3h 32m

$227

SavannahKnoxville

SAV Savannah/Hilton Head - TYS Knoxville McGhee Tyson

SAVTYS

Savannah/Hilton Head

Tue 9/1

6:45 am-12:05 pm

1 stop5h 20m

Knoxville McGhee Tyson

Sun 9/6

6:10 pm-9:35 pm

1 stop3h 25m

$231

SavannahKnoxville

SAV Savannah/Hilton Head - TYS Knoxville McGhee Tyson

SAVTYS

Savannah/Hilton Head

Mon 8/31

6:50 am-12:20 pm

1 stop5h 30m

Knoxville McGhee Tyson

Sun 9/6

6:10 pm-9:35 pm

1 stop3h 25m

$231

CharlestonKnoxville

CHS Charleston - TYS Knoxville McGhee Tyson

CHSTYS

Charleston

Mon 8/24

9:44 pm-9:40 am

1 stop11h 56m

Knoxville McGhee Tyson

Wed 8/26

10:54 am-8:38 am

1 stop21h 44m

$232
Quickest round-trip

CharlestonKnoxville

CHS Charleston - TYS Knoxville McGhee Tyson

CHSTYS

Charleston

Tue 9/8

7:48 pm-10:58 pm

1 stop3h 10m

Knoxville McGhee Tyson

Tue 9/15

6:15 am-9:47 am

1 stop3h 32m

$239

SavannahKnoxville

SAV Savannah/Hilton Head - TYS Knoxville McGhee Tyson

SAVTYS

Savannah/Hilton Head

Wed 10/14

5:30 am-10:54 am

1 stop5h 24m

Knoxville McGhee Tyson

Wed 10/14

6:23 pm-11:57 pm

1 stop5h 34m

$269

CharlestonKnoxville

CHS Charleston - TYS Knoxville McGhee Tyson

CHSTYS

Charleston

Mon 10/19

7:04 pm-11:55 pm

1 stop4h 51m

Knoxville McGhee Tyson

Sat 10/24

7:58 pm-12:05 am

1 stop4h 07m

$269

SavannahKnoxville

SAV Savannah/Hilton Head - TYS Knoxville McGhee Tyson

SAVTYS

Savannah/Hilton Head

Fri 12/11

5:00 am-10:30 am

1 stop5h 30m

Knoxville McGhee Tyson

Mon 12/14

8:13 pm-12:03 am

1 stop3h 50m

$272

SavannahKnoxville

SAV Savannah/Hilton Head - TYS Knoxville McGhee Tyson

SAVTYS

Savannah/Hilton Head

Fri 12/11

12:45 pm-6:26 pm

1 stop5h 41m

Knoxville McGhee Tyson

Mon 12/14

4:03 pm-7:05 pm

1 stop3h 02m

$279

SavannahKnoxville

SAV Savannah/Hilton Head - TYS Knoxville McGhee Tyson

SAVTYS

Savannah/Hilton Head

Thu 12/10

5:30 am-9:50 am

1 stop4h 20m

Knoxville McGhee Tyson

Sun 12/13

7:21 pm-11:58 pm

1 stop4h 37m

$307

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from South Carolina to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of December is, on average, the cheapest month to fly to Knoxville from South Carolina, with most prices found around $316. If you aren’t able to travel during the month of December, then book flights to Knoxville from South Carolina during October instead. Flights to Knoxville in October, while not as cheap as those in December, still average around $316.

Cheap South Carolina to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Knoxville

Fastest flight time

1h 13m

Direct flights

Every day

Airports in Knoxville

1 airport
The fastest flight from South Carolina to Knoxville takes 1h 13m
Direct flights go from South Carolina to Knoxville every day.
There is 1 airport in Knoxville. From South Carolina there are direct flights to Knoxville McGhee Tyson (TYS).
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Frequently asked questions about flying from South Carolina to Knoxville

  • When did momondo last update prices for flights from South Carolina to Knoxville McGhee Tyson Airport?

    Prices for flights from South Carolina to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from South Carolina to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from South Carolina to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from South Carolina to Knoxville

Compare and see reviews for airlines that fly from South Carolina to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $254Free CancellationRating
7.8
8,505 reviews
Search Delta flights
American AirlinesPriceFrom $283Free CancellationRating
7.1
11,902 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Carolina to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Carolina to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Knoxville?

Once you have performed a search for South Carolina to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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