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Cheap flights from South Carolina to Knoxville from $136

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Carolina to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:15 am - 9:38 amMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
3h 23m1 stop Charlotte Douglas
American Airlines Logo
5:19 pm - 10:29 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
5h 10m1 stop Charlotte Douglas
$273American Airlines
Tue, Oct 27 - Tue, Nov 3
American Airlines Logo
5:00 am - 10:23 amMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
5h 23m1 stop Charlotte Douglas
American Airlines Logo
4:49 pm - 10:02 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
5h 13m1 stop Charlotte Douglas
$273American Airlines
Wed, Oct 21 - Wed, Oct 28
American Airlines Logo
5:03 pm - 8:43 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
3h 40m1 stop Charlotte Douglas
American Airlines Logo
7:20 pm - 10:44 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
3h 24m1 stop Charlotte Douglas
$273American Airlines
Wed, Nov 4 - Sat, Nov 14
Delta Logo
6:30 am - 9:34 amCHS  Charleston-TYS Knoxville McGhee Tyson
3h 04m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:40 am - 9:25 amTYS  Knoxville McGhee Tyson-CHS Charleston
3h 45m1 stop Atlanta Hartsfield-Jackson
$287Delta
Thu, Oct 29 - Thu, Nov 5
Delta Logo
4:11 pm - 8:09 pmCHS  Charleston-TYS Knoxville McGhee Tyson
3h 58m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:10 pm - 11:59 pmTYS  Knoxville McGhee Tyson-CHS Charleston
5h 49m1 stop Atlanta Hartsfield-Jackson
$287Delta
Thu, Nov 12 - Sat, Nov 14
American Airlines Logo
5:05 am - 8:32 amCHS  Charleston-TYS Knoxville McGhee Tyson
3h 27m1 stop Charlotte Douglas
American Airlines Logo
6:01 am - 11:23 amTYS  Knoxville McGhee Tyson-CHS Charleston
5h 22m1 stop Charlotte Douglas
$287American Airlines
Wed, Oct 28 - Wed, Nov 4
Delta Logo
2:00 pm - 8:09 pmCHS  Charleston-TYS Knoxville McGhee Tyson
6h 09m1 stop Atlanta Hartsfield-Jackson
Delta Logo
11:02 am - 3:09 pmTYS  Knoxville McGhee Tyson-CHS Charleston
4h 07m1 stop Atlanta Hartsfield-Jackson
$287Delta
Thu, Nov 12 - Sat, Nov 14
Multiple Airlines Logo
4:57 pm - 5:14 pmCHS  Charleston-TYS Knoxville McGhee Tyson
24h 17m1 stop Fort Lauderdale
Multiple Airlines Logo
7:00 am - 8:38 amTYS  Knoxville McGhee Tyson-CHS Charleston
25h 38m1 stop Orlando
$290Multiple Airlines
Mon, Oct 26 - Mon, Nov 2
Multiple Airlines Logo
3:00 pm - 11:29 amCHS  Charleston-TYS Knoxville McGhee Tyson
44h 29m2 stops Orlando Washington, D.C. Dulles Intl
Multiple Airlines Logo
6:04 pm - 7:14 pmTYS  Knoxville McGhee Tyson-CHS Charleston
25h 10m1 stop Fort Lauderdale
$293Multiple Airlines
Tue, Oct 27 - Tue, Nov 3
Multiple Airlines Logo
9:41 am - 10:05 amGSP  Greenville-TYS Knoxville McGhee Tyson
24h 24m1 stop Fort Lauderdale
Multiple Airlines Logo
6:04 pm - 7:44 pmTYS  Knoxville McGhee Tyson-GSP Greenville
25h 40m2 stops Fort Lauderdale Tampa
$298Multiple Airlines
Fri, Oct 30 - Tue, Nov 3

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Southwest flights from South Carolina to Knoxville

Our best Southwest deals on South Carolina to Knoxville flight tickets
Southwest
Oct 30
GSP2:10 pmGreenville
7h 25m
1 stop
TYS9:35 pmKnoxville McGhee Tyson
Nov 2
TYS7:25 pmKnoxville McGhee Tyson
3h 30m
1 stop
GSP10:55 pmGreenville
$302
Southwest
Nov 11
CHS6:35 amCharleston
5h 45m
1 stop
TYS12:20 pmKnoxville McGhee Tyson
Nov 13
TYS7:25 pmKnoxville McGhee Tyson
14h 40m
2 stops
CHS10:05 amCharleston
$309
Southwest
Jan 30
MYR8:10 amMyrtle Beach Intl
9h 30m
2 stops
TYS5:40 pmKnoxville McGhee Tyson
Jan 31
TYS6:50 amKnoxville McGhee Tyson
6h 05m
1 stop
MYR12:55 pmMyrtle Beach Intl
$315

Delta flights from South Carolina to Knoxville

Our best Delta deals on South Carolina to Knoxville flight tickets
Delta
Oct 28
CHS5:30 amCharleston
4h 04m
1 stop
TYS9:34 amKnoxville McGhee Tyson
Nov 4
TYS5:40 amKnoxville McGhee Tyson
3h 45m
1 stop
CHS9:25 amCharleston
$287
Delta
Nov 11
CHS6:34 amCharleston
3h 21m
1 stop
TYS9:55 amKnoxville McGhee Tyson
Nov 13
TYS4:00 pmKnoxville McGhee Tyson
4h 13m
1 stop
CHS8:13 pmCharleston
$298
Delta
Nov 12
CHS4:11 pmCharleston
3h 58m
1 stop
TYS8:09 pmKnoxville McGhee Tyson
Nov 15
TYS7:22 pmKnoxville McGhee Tyson
4h 37m
1 stop
CHS11:59 pmCharleston
$327

momondo Fare Finder

 
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

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Route

Depart

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Price

Cheapest round-trip

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Tue 10/27

6:15 am-9:38 am

1 stop3h 23m

Knoxville McGhee Tyson

Tue 11/3

5:19 pm-10:29 pm

1 stop5h 10m

$273

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Wed 10/21

5:00 am-10:23 am

1 stop5h 23m

Knoxville McGhee Tyson

Wed 10/28

4:49 pm-10:02 pm

1 stop5h 13m

$273

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Wed 11/4

5:03 pm-8:43 pm

1 stop3h 40m

Knoxville McGhee Tyson

Sat 11/14

7:20 pm-10:44 pm

1 stop3h 24m

$273
Quickest round-trip

CharlestonKnoxville

CHS Charleston - TYS Knoxville McGhee Tyson

CHSTYS

Charleston

Thu 10/29

6:30 am-9:34 am

1 stop3h 04m

Knoxville McGhee Tyson

Thu 11/5

5:40 am-9:25 am

1 stop3h 45m

$287

CharlestonKnoxville

CHS Charleston - TYS Knoxville McGhee Tyson

CHSTYS

Charleston

Thu 11/12

4:11 pm-8:09 pm

1 stop3h 58m

Knoxville McGhee Tyson

Sat 11/14

6:10 pm-11:59 pm

1 stop5h 49m

$287

CharlestonKnoxville

CHS Charleston - TYS Knoxville McGhee Tyson

CHSTYS

Charleston

Wed 10/28

5:05 am-8:32 am

1 stop3h 27m

Knoxville McGhee Tyson

Wed 11/4

6:01 am-11:23 am

1 stop5h 22m

$287

CharlestonKnoxville

CHS Charleston - TYS Knoxville McGhee Tyson

CHSTYS

Charleston

Thu 11/12

2:00 pm-8:09 pm

1 stop6h 09m

Knoxville McGhee Tyson

Sat 11/14

11:02 am-3:09 pm

1 stop4h 07m

$287

CharlestonKnoxville

CHS Charleston - TYS Knoxville McGhee Tyson

CHSTYS

Charleston

Mon 10/26

4:57 pm-5:14 pm

1 stop24h 17m

Knoxville McGhee Tyson

Mon 11/2

7:00 am-8:38 am

1 stop25h 38m

$290

CharlestonKnoxville

CHS Charleston - TYS Knoxville McGhee Tyson

CHSTYS

Charleston

Tue 10/27

3:00 pm-11:29 am

2 stops44h 29m

Knoxville McGhee Tyson

Tue 11/3

6:04 pm-7:14 pm

1 stop25h 10m

$293

GreenvilleKnoxville

GSP Greenville - TYS Knoxville McGhee Tyson

GSPTYS

Greenville

Fri 10/30

9:41 am-10:05 am

1 stop24h 24m

Knoxville McGhee Tyson

Tue 11/3

6:04 pm-7:44 pm

2 stops25h 40m

$298

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from South Carolina to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of March is, on average, the cheapest month to fly to Knoxville from South Carolina, with most prices found around $0. If you aren’t able to travel during the month of March, then book flights to Knoxville from South Carolina during January instead. Flights to Knoxville in January, while not as cheap as those in March, still average around $254.

Cheap South Carolina to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Knoxville

Best Price Found

$136

Fastest flight time

1h 13m

Direct flights

None
The best one-way flight to Knoxville from South Carolina in the past 72 hours is $136. The best round-trip flight deal from South Carolina to Knoxville found on momondo in the last 72 hours is $273.
The fastest flight from South Carolina to Knoxville takes 1h 13m
There are no direct flights from South Carolina to Knoxville. There are no popular flight routes from South Carolina to Knoxville.
Search flight deals

Frequently asked questions about flying from South Carolina to Knoxville

  • When did momondo last update prices for flights from South Carolina to Knoxville McGhee Tyson Airport?

    Prices for flights from South Carolina to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from South Carolina to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from South Carolina to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from South Carolina to Knoxville

Compare and see reviews for airlines that fly from South Carolina to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $254Free CancellationRating
7.8
8,608 reviews
Search Delta flights
American AirlinesPriceFrom $316Free CancellationRating
7.0
12,097 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Rockford
Jefferson City

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Carolina to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Carolina to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Knoxville?

Once you have performed a search for South Carolina to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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