What is the cheapest airline that flies from South Carolina to Iowa?

Delta, American Airlines, and Southwest are the most popular carriers operating from South Carolina to Iowa

How long is the flight from South Carolina to Iowa?

Flight times vary depending on what airport in South Carolina you fly out of and what airport in Iowa you fly into. For example, flying from Charleston to Des Moines takes 4h 25m on average. On the other hand, flying from Myrtle Beach to Des Moines takes 4h 40m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.

What airlines fly to Iowa?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Iowa from South Carolina according to our data. American Airlines is the first choice among our users, with 61% of people opting to fly with this airline when traveling to Iowa. Keep in mind that there are 3 different airlines that fly to Iowa on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from South Carolina to Iowa?

Prices for flights from South Carolina to Iowa are updated daily.

How many operators does momondo search for flights from South Carolina to Iowa?

As of October 2026, there are 3 operators available to choose from for flights from South Carolina to Iowa.

How old do you have to be to fly from South Carolina to Iowa?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Iowa.

What documentation or ID do you need to fly to Iowa?

The necessary travel and health documents for your Iowa trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$161 Cheap Flights from South Carolina to Iowa in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Carolina to Iowa

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

3:14 pm - 10:08 pmCHS Charleston-DSM Des Moines

7h 54m1 stop Fort Myers SW Florida Intl

8:30 am - 8:38 amDSM Des Moines-CHS Charleston

23h 08m2 stops Nashville Intl Orlando

$300Multiple Airlines

Fri, Oct 30 - Mon, Nov 2

3:14 pm - 10:15 pmCHS Charleston-DSM Des Moines

8h 01m1 stop Fort Myers SW Florida Intl

6:45 am - 8:38 amDSM Des Moines-CHS Charleston

24h 53m2 stops Nashville Intl Orlando

$316Multiple Airlines

Fri, Nov 6 - Mon, Nov 9

3:14 pm - 10:08 pmCHS Charleston-DSM Des Moines

7h 54m1 stop Fort Myers SW Florida Intl

11:52 am - 8:38 amDSM Des Moines-CHS Charleston

19h 46m1 stop Orlando Sanford Intl

$318Multiple Airlines

Fri, Oct 30 - Mon, Nov 2

6:15 am - 12:23 pmMYR Myrtle Beach Intl-DSM Des Moines

7h 08m1 stop Charlotte Douglas

3:31 pm - 10:34 pmDSM Des Moines-MYR Myrtle Beach Intl

6h 03m1 stop Dallas/Fort Worth

$325American Airlines

Tue, Oct 27 - Tue, Nov 3

4:55 pm - 10:45 pmGSP Greenville-DSM Des Moines

6h 50m1 stop Washington, D.C. Reagan-National

9:25 am - 4:07 pmDSM Des Moines-GSP Greenville

5h 42m1 stop Chicago O'Hare Intl

$325American Airlines

Wed, Oct 28 - Wed, Nov 4

5:40 am - 10:42 amGSP Greenville-DSM Des Moines

6h 02m1 stop Atlanta Hartsfield-Jackson

4:07 pm - 10:51 pmDSM Des Moines-GSP Greenville

5h 44m1 stop Atlanta Hartsfield-Jackson

$325Delta

Wed, Oct 28 - Wed, Nov 4

10:30 am - 3:16 pmCHS Charleston-DSM Des Moines

5h 46m1 stop Atlanta Hartsfield-Jackson

4:07 pm - 9:44 pmDSM Des Moines-CHS Charleston

4h 37m1 stop Atlanta Hartsfield-Jackson

$325Delta

Tue, Nov 3 - Sat, Nov 7

5:28 pm - 11:26 pmCHS Charleston-DSM Des Moines

6h 58m1 stop Charlotte Douglas

9:25 am - 3:24 pmDSM Des Moines-CHS Charleston

4h 59m1 stop Chicago O'Hare Intl

$325American Airlines

Sat, Nov 7 - Mon, Nov 9

6:20 am - 10:32 amGSP Greenville-DSM Des Moines

5h 12m1 stop Chicago O'Hare Intl

8:00 am - 7:01 pmDSM Des Moines-GSP Greenville

10h 01m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

$330United Airlines

Wed, Oct 28 - Wed, Nov 4

2:52 pm - 9:55 pmCHS Charleston-DSM Des Moines

8h 03m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

8:00 am - 1:56 pmDSM Des Moines-CHS Charleston

4h 56m1 stop Chicago O'Hare Intl

$330United Airlines

Mon, Nov 2 - Sat, Nov 7

Cheap last minute flights

Enter your travel dates to find the best prices.

3:53 pm - 9:56 pmCAE Columbia Metropolitan-CID Cedar Rapids

7h 03m1 stop Atlanta Hartsfield-Jackson

5:30 am - 1:14 pmCID Cedar Rapids-CAE Columbia Metropolitan

6h 44m1 stop Atlanta Hartsfield-Jackson

$399Delta

Tue, Oct 6 - Sun, Oct 11

3:53 pm - 9:56 pmCAE Columbia Metropolitan-CID Cedar Rapids

7h 03m1 stop Atlanta Hartsfield-Jackson

5:30 am - 1:14 pmCID Cedar Rapids-CAE Columbia Metropolitan

6h 44m1 stop Atlanta Hartsfield-Jackson

$411Delta

Wed, Oct 7 - Sun, Oct 11

5:29 pm - 10:59 pmCHS Charleston-CID Cedar Rapids

6h 30m1 stop Minneapolis St Paul

12:10 pm - 11:59 pmCID Cedar Rapids-CHS Charleston

10h 49m2 stops Minneapolis St Paul Atlanta Hartsfield-Jackson

$464Delta

Fri, Oct 2 - Mon, Oct 5

5:59 pm - 11:58 pmCAE Columbia Metropolitan-CID Cedar Rapids

6h 59m1 stop Charlotte Douglas

7:00 am - 2:03 pmCID Cedar Rapids-CAE Columbia Metropolitan

6h 03m1 stop Charlotte Douglas

$474American Airlines

Wed, Oct 7 - Sun, Oct 11

3:28 pm - 12:20 amCAE Columbia Metropolitan-CID Cedar Rapids

9h 52m2 stops Charlotte Douglas Chicago O'Hare Intl

7:00 am - 2:03 pmCID Cedar Rapids-CAE Columbia Metropolitan

6h 03m1 stop Charlotte Douglas

$542American Airlines

Tue, Oct 6 - Sun, Oct 11

4:08 pm - 12:20 amCAE Columbia Metropolitan-CID Cedar Rapids

9h 12m2 stops Charlotte Douglas Chicago O'Hare Intl

7:00 am - 12:19 pmCID Cedar Rapids-CAE Columbia Metropolitan

4h 19m1 stop Charlotte Douglas

$542American Airlines

Wed, Oct 7 - Sun, Oct 11

3:59 pm - 10:13 pmCHS Charleston-DSM Des Moines

7h 14m1 stop Fort Myers SW Florida Intl

6:40 am - 8:48 amDSM Des Moines-CHS Charleston

25h 08m2 stops Philadelphia Orlando

$571Multiple Airlines

Fri, Oct 2 - Sun, Oct 4

3:59 pm - 10:13 pmCHS Charleston-DSM Des Moines

7h 14m1 stop Fort Myers SW Florida Intl

1:02 pm - 12:33 pmDSM Des Moines-CHS Charleston

22h 31m2 stops Las Vegas Harry Reid Intl New Orleans Louis Armstrong

$584Multiple Airlines

Fri, Oct 2 - Mon, Oct 5

5:46 pm - 9:23 pmGSP Greenville-DSM Des Moines

4h 37m1 stop Chicago O'Hare Intl

5:45 am - 3:08 pmDSM Des Moines-GSP Greenville

8h 23m1 stop Denver Intl

$672United Airlines

Tue, Oct 6 - Wed, Oct 7

2:16 pm - 11:48 pmGSP Greenville-DSM Des Moines

10h 32m2 stops Chicago O'Hare Intl Denver Intl

3:11 pm - 9:17 pmDSM Des Moines-GSP Greenville

5h 06m1 stop Chicago O'Hare Intl

$682United Airlines

Tue, Oct 6 - Wed, Oct 7

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United Airlines flights from South Carolina to Iowa

Our best United Airlines deals on South Carolina to Iowa flight tickets

United Airlines

Nov 2

CHS2:52 pmCharleston

8h 03m

2 stops

DSM9:55 pmDes Moines

Nov 7

DSM8:00 amDes Moines

4h 56m

1 stop

CHS1:56 pmCharleston

$330

United Airlines

Oct 23

CHS4:58 pmCharleston

5h 25m

1 stop

DSM9:23 pmDes Moines

Oct 27

DSM8:00 amDes Moines

8h 39m

2 stops

CHS5:39 pmCharleston

$355

United Airlines

Oct 28

GSP10:26 amGreenville

8h 01m

2 stops

DSM5:27 pmDes Moines

Nov 4

DSM9:55 amDes Moines

8h 06m

2 stops

GSP7:01 pmGreenville

$360

Southwest flights from South Carolina to Iowa

Our best Southwest deals on South Carolina to Iowa flight tickets

Southwest

Oct 27

MYR7:50 amMyrtle Beach Intl

4h 40m

1 stop

DSM11:30 amDes Moines

Nov 3

DSM6:00 amDes Moines

11h 25m

2 stops

MYR6:25 pmMyrtle Beach Intl

$336

Southwest

Oct 27

MYR1:35 pmMyrtle Beach Intl

9h 25m

2 stops

DSM10:00 pmDes Moines

Nov 3

DSM6:00 amDes Moines

11h 25m

2 stops

MYR6:25 pmMyrtle Beach Intl

$350

Southwest

Nov 2

CHS5:30 amCharleston

8h 40m

2 stops

DSM1:10 pmDes Moines

Nov 7

DSM7:00 amDes Moines

11h 05m

2 stops

CHS7:05 pmCharleston

$385

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Fri 10/30

3:14 pm-10:08 pm

1 stop7h 54m

Des Moines

Mon 11/2

8:30 am-8:38 am

2 stops23h 08m

$300

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Fri 11/6

3:14 pm-10:15 pm

1 stop8h 01m

Des Moines

Mon 11/9

6:45 am-8:38 am

2 stops24h 53m

$316

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Fri 10/30

3:14 pm-10:08 pm

1 stop7h 54m

Des Moines

Mon 11/2

11:52 am-8:38 am

1 stop19h 46m

$318

Myrtle BeachDes Moines

MYR Myrtle Beach Intl - DSM Des Moines

MYRDSM

Myrtle Beach Intl

Tue 10/27

6:15 am-12:23 pm

1 stop7h 08m

Des Moines

Tue 11/3

3:31 pm-10:34 pm

1 stop6h 03m

$325

GreenvilleDes Moines

GSP Greenville - DSM Des Moines

GSPDSM

Greenville

Wed 10/28

4:55 pm-10:45 pm

1 stop6h 50m

Des Moines

Wed 11/4

9:25 am-4:07 pm

1 stop5h 42m

$325

GreenvilleDes Moines

GSP Greenville - DSM Des Moines

GSPDSM

Greenville

Wed 10/28

5:40 am-10:42 am

1 stop6h 02m

Des Moines

Wed 11/4

4:07 pm-10:51 pm

1 stop5h 44m

$325

Quickest round-trip

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Tue 11/3

10:30 am-3:16 pm

1 stop5h 46m

Des Moines

Sat 11/7

4:07 pm-9:44 pm

1 stop4h 37m

$325

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Sat 11/7

5:28 pm-11:26 pm

1 stop6h 58m

Des Moines

Mon 11/9

9:25 am-3:24 pm

1 stop4h 59m

$325

GreenvilleDes Moines

GSP Greenville - DSM Des Moines

GSPDSM

Greenville

Wed 10/28

6:20 am-10:32 am

1 stop5h 12m

Des Moines

Wed 11/4

8:00 am-7:01 pm

2 stops10h 01m

$330

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Mon 11/2

2:52 pm-9:55 pm

2 stops8h 03m

Des Moines

Sat 11/7

8:00 am-1:56 pm

1 stop4h 56m

$330

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Carolina to Iowa

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Iowa?

The month of June is another great option to travel to Iowa, with average flight prices from South Carolina averaging around $376.

Can stopping save me money on South Carolina to Iowa flights?

You could potentially save up to 68% on your flight if you consider stops on a South Carolina to Iowa flight.

Cheap South Carolina to Iowa flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Iowa

Best Price Found	$161
Fastest flight time	2h 14m
Direct flights	None

The best one-way flight to Iowa from South Carolina in the past 72 hours is $161. The best round-trip flight deal from South Carolina to Iowa found on momondo in the last 72 hours is $300.

The fastest flight from South Carolina to Iowa takes 2h 14m

There are no direct flights from South Carolina to Iowa. There are no popular flight routes from South Carolina to Iowa.

Search flight deals

Frequently asked questions about flying from South Carolina to Iowa

When did momondo last update prices for flights from South Carolina to Iowa?
Prices for flights from South Carolina to Iowa are updated daily.
How many operators does momondo search for flights from South Carolina to Iowa?
As of October 2026, there are 3 operators available to choose from for flights from South Carolina to Iowa.
How old do you have to be to fly from South Carolina to Iowa?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Iowa.
What documentation or ID do you need to fly to Iowa?
The necessary travel and health documents for your Iowa trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Carolina to Iowa

Compare and see reviews for airlines that fly from South Carolina to Iowa with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $233	Free Cancellation	Rating 7.0 12,101 reviews	Search American Airlines flights
United Airlines	PriceFrom $280	Free Cancellation	Rating 7.4 10,270 reviews	Search United Airlines flights
Delta	PriceFrom $286	Free Cancellation	Rating 7.8 8,615 reviews	Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Iowa?

Finding the right flight to Iowa from South Carolina is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Iowa quick and easy, saving you time and money.

Can I find flights from South Carolina to Iowa with flexible booking policies on momondo?

All flight searches from South Carolina to Iowa on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from South Carolina to Iowa?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Iowa.

I’m not ready to book a flight from South Carolina to Iowa right now. Can momondo alert me if prices change?

Price alerts on flights to Iowa from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.