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Cheap flights from South Carolina to Florida Keys from $42

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Florida Keys departing on 8/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from South Carolina to Florida Keys

Cheap round-trip flights

Frontier Logo
10:20 pm - 12:42 amCLT-MIA
2h 22mnonstop
Frontier Logo
6:00 am - 8:11 amMIA-CLT
2h 11mnonstop
$84Frontier
Find Deal
Fri, Sep 19 - Sun, Sep 28
Spirit Airlines Logo
1:43 pm - 3:48 pmCLT-MIA
2h 05mnonstop
Spirit Airlines Logo
10:23 am - 12:38 pmMIA-CLT
2h 15mnonstop
$87Spirit Airlines
Find Deal
Thu, Aug 21 - Mon, Aug 25
Logo
1:43 pm - 3:48 pmCLT-MIA
2h 05mnonstop
Logo
9:00 am - 11:17 amMIA-CLT
2h 17mnonstop
$113
Find Deal
Thu, Aug 28 - Sun, Aug 31
Logo
9:12 am - 11:35 amCLT-MIA
2h 23mnonstop
Logo
10:23 am - 12:38 pmMIA-CLT
2h 15mnonstop
$118
Find Deal
Sun, Aug 17 - Sat, Aug 23
Breeze Airways Logo
2:48 pm - 9:22 amCHS-EYW
18h 34m1 stop
Breeze Airways Logo
10:02 am - 9:14 amEYW-CHS
23h 12m1 stop
$149Breeze Airways
Find Deal
Sat, Aug 23 - Tue, Aug 26
Breeze Airways Logo
8:59 pm - 8:07 amCHS-EYW
11h 08m1 stop
Breeze Airways Logo
8:47 am - 8:37 amEYW-CHS
23h 50m1 stop
$157Breeze Airways
Find Deal
Thu, Sep 4 - Mon, Sep 8
American Airlines Logo
7:08 am - 8:50 amCHS-MIA
1h 42mnonstop
American Airlines Logo
7:50 am - 9:39 amMIA-CHS
1h 49mnonstop
$159American Airlines
Find Deal
Wed, Sep 10 - Sat, Sep 13
American Airlines Logo
9:45 am - 11:17 amSAV-MIA
1h 32mnonstop
American Airlines Logo
10:29 pm - 11:59 pmMIA-SAV
1h 30mnonstop
$159American Airlines
Find Deal
Sat, Oct 11 - Sat, Oct 18
Delta Logo
10:25 am - 3:20 pmCHS-MIA
4h 55m1 stop
Delta Logo
6:00 am - 11:48 amMIA-CHS
5h 48m1 stop
$179Delta
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Wed, Sep 10 - Sat, Sep 13
Delta Logo
6:59 pm - 12:29 amSAV-MIA
5h 30m1 stop
Delta Logo
6:00 am - 11:04 amMIA-SAV
5h 04m1 stop
$179Delta
Find Deal
Sat, Oct 11 - Sat, Oct 18

Spirit Airlines flights from South Carolina to Florida Keys

Our best Spirit Airlines deals on South Carolina to Florida Keys flight tickets
Spirit Airlines
Aug 21
CLT1:43 pmCharlotte Douglas
2h 05m
MIA3:48 pmMiami
Aug 25
MIA10:23 amMiami
2h 15m
CLT12:38 pmCharlotte Douglas
$87
Find similar
Spirit Airlines
Aug 22
CLT1:43 pmCharlotte Douglas
2h 05m
MIA3:48 pmMiami
Aug 25
MIA10:23 amMiami
2h 15m
CLT12:38 pmCharlotte Douglas
$96
Find similar
Spirit Airlines
Aug 22
CLT1:43 pmCharlotte Douglas
2h 05m
MIA3:48 pmMiami
Aug 24
MIA10:23 amMiami
2h 15m
CLT12:38 pmCharlotte Douglas
$101
Find similar

American Airlines flights from South Carolina to Florida Keys

Our best American Airlines deals on South Carolina to Florida Keys flight tickets
American Airlines
Oct 11
SAV9:45 amSavannah/Hilton Head
1h 32m
MIA11:17 amMiami
Oct 18
MIA10:29 pmMiami
1h 30m
SAV11:59 pmSavannah/Hilton Head
$159
Find similar
American Airlines
Sep 3
CHS7:08 amCharleston
1h 43m
MIA8:51 amMiami
Sep 10
MIA9:46 pmMiami
1h 51m
CHS11:37 pmCharleston
$160
Find similar
American Airlines
Oct 23
MYR5:59 pmMyrtle Beach Intl
6h 30m
1 stop
MIA12:29 amMiami
Oct 27
MIA6:20 amMiami
4h 06m
1 stop
MYR10:26 amMyrtle Beach Intl
$173
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 6, 2025.
Use the filters below to find and compare flights from South Carolina to Florida Keys that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Fri 9/19

10:20 pm-12:42 am

Nonstop2h 22m

Miami

Sun 9/28

6:00 am-8:11 am

Nonstop2h 11m

$84

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Thu 8/21

1:43 pm-3:48 pm

Nonstop2h 05m

Miami

Mon 8/25

10:23 am-12:38 pm

Nonstop2h 15m

$87

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Thu 8/28

1:43 pm-3:48 pm

Nonstop2h 05m

Miami

Sun 8/31

9:00 am-11:17 am

Nonstop2h 17m

$113

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Sun 8/17

9:12 am-11:35 am

Nonstop2h 23m

Miami

Sat 8/23

10:23 am-12:38 pm

Nonstop2h 15m

$118

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Sat 8/23

2:48 pm-9:22 am

1 stop18h 34m

Key West

Tue 8/26

10:02 am-9:14 am

1 stop23h 12m

$149

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Thu 9/4

8:59 pm-8:07 am

1 stop11h 08m

Key West

Mon 9/8

8:47 am-8:37 am

1 stop23h 50m

$157

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Wed 9/10

7:08 am-8:50 am

Nonstop1h 42m

Miami

Sat 9/13

7:50 am-9:39 am

Nonstop1h 49m

$159

SavannahMiami

SAV - MIA

SAVMIA

Savannah/Hilton Head

Sat 10/11

9:45 am-11:17 am

Nonstop1h 32m

Miami

Sat 10/18

10:29 pm-11:59 pm

Nonstop1h 30m

$159

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Wed 9/10

10:25 am-3:20 pm

1 stop4h 55m

Miami

Sat 9/13

6:00 am-11:48 am

1 stop5h 48m

$179

SavannahMiami

SAV - MIA

SAVMIA

Savannah/Hilton Head

Sat 10/11

6:59 pm-12:29 am

1 stop5h 30m

Miami

Sat 10/18

6:00 am-11:04 am

1 stop5h 04m

$179

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Florida Keys from

How to get the cheapest flight ticket from South Carolina to Florida Keys

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Florida Keys?

The month of August is another great option to travel to Florida Keys, with average flight prices from South Carolina averaging around $231.

What is the cheapest day to depart on your flight to Florida Keys?

The cheapest day to depart from South Carolina to Florida Keys is on a Wednesday when prices can be found for as low as $484. The most expensive day to fly to Florida Keys is Sunday, with ticket prices averaging around $556.

What is the cheapest time of day to depart on your flight to Florida Keys?

According to our data, the cheapest time of day to fly to Florida Keys is in the evening. momondo users have found flights departing from South Carolina to Florida Keys in the evening for as low as $348. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights in the afternoon are often more expensive with an average ticket price of $665.

How far in advance should I book a flight to Florida Keys?

You are more likely to see cheaper flights to Florida Keys from South Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Florida Keys for around $286 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Florida Keys from South Carolina for as low as $224 on momondo.

Can stopping save me money on South Carolina to Florida Keys flights?

No. A direct flight is the cheapest option for a flight between South Carolina to Florida Keys.

Cheap South Carolina to Florida Keys flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Florida Keys

Best Price Found

$42

Fastest flight time

1h 27m

Direct flights

Every day

Airports in Florida Keys

2 airports
The best one-way flight to Florida Keys from South Carolina in the past 72 hours is $42. The best round-trip flight deal from South Carolina to Florida Keys found on momondo in the last 72 hours is $84.
The fastest flight from South Carolina to Florida Keys takes 1h 27m
Direct flights go from South Carolina to Florida Keys every day.
There are 2 airports near Florida Keys: Key West (EYW), Miami (MIA)
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Florida Keys?

    Prices for flights from South Carolina to Florida Keys are refreshed on a daily basis.

  • How many operators does momondo search for flights from South Carolina to Florida Keys?

  • How old do you have to be to fly from South Carolina to Florida Keys?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Florida Keys.

  • What documentation or ID do you need to fly to Florida Keys?

    The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from South Carolina to Florida Keys?

Best airlines flying from South Carolina to Florida Keys

Compare and see reviews for airlines that fly from South Carolina to Florida Keys with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $198Free CancellationRating
8.0
7,985 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Florida Keys?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Florida Keys from South Carolina.

Can I find flights from South Carolina to Florida Keys with flexible booking policies on momondo?

All flight searches from South Carolina to Florida Keys on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from South Carolina to Florida Keys?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Florida Keys.

I’m not ready to book a flight from South Carolina to Florida Keys right now. Can momondo alert me if prices change?

Yes. momondo can track prices for South Carolina to Florida Keys flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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