How long is the flight from South Carolina to Florida Keys?

On average, it takes 5h 06m to fly from South Carolina to Florida Keys if you fly out of Greenville (the most popular airport in South Carolina) and into Los Angeles (the most popular airport in Florida Keys). If you’re flying out of Charleston and into Los Angeles, then the flight time is around 5h 25m.

What airlines fly to Florida Keys?

American Airlines, Delta and Breeze Airways are the top three most popular airlines that fly to Florida Keys from South Carolina according to our data. American Airlines is the first choice among our users, with 62% of people opting to fly with this airline when traveling to Florida Keys. Keep in mind that there are 3 different airlines that fly to Florida Keys on a routine basis, so you have a few additional options to choose from.

How many flights depart from South Carolina to Florida Keys on average per week?

As of May 2026, there are 282 flights per week flying from South Carolina to Florida Keys. The most common day of the week flights depart is Fri, with 15% of flights taking off on this day.

What is the cheapest airline that flies from South Carolina to Florida Keys?

Breeze Airways, Southwest, and Delta are the most popular carriers operating from South Carolina to Florida Keys

When did momondo last update prices for flights from South Carolina to Florida Keys?

Prices for flights from South Carolina to Florida Keys are refreshed on a daily basis.

How many operators does momondo search for flights from South Carolina to Florida Keys?

There are 8 operators available for flights from South Carolina to Florida Keys as of May 2026.

How old do you have to be to fly from South Carolina to Florida Keys?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Florida Keys.

What documentation or ID do you need to fly to Florida Keys?

The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$83 Cheap Flights from South Carolina to Florida Keys in 2026

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Find the cheapest flights from South Carolina to Florida Keys

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

4:34 pm - 11:25 am

CHS

EYW

18h 51m

1 stop

1:14 pm - 12:50 pm

EYW

CHS

23h 36m

1 stop

$156Breeze Airways

Wed, May 27 - Tue, Jun 2

6:00 am - 9:24 am

CHS

EYW

3h 24m

1 stop

10:04 am - 1:24 pm

EYW

CHS

3h 20m

1 stop

$164Breeze Airways

Sat, Sep 26 - Sat, Oct 3

1:00 pm - 8:33 pm

CLT

MIA

7h 33m

1 stop

2:53 pm - 5:12 pm

MIA

CLT

2h 19mnonstop

$172Frontier

Tue, Jul 14 - Tue, Jul 21

10:20 pm - 12:29 am

CLT

MIA

2h 09mnonstop

7:00 am - 9:16 am

MIA

CLT

2h 16mnonstop

$173Frontier

Tue, Jun 9 - Wed, Jun 10

6:00 am - 7:43 am

CHS

MIA

1h 43mnonstop

5:00 pm - 6:51 pm

MIA

CHS

1h 51mnonstop

$207American Airlines

Wed, Jul 22 - Wed, Jul 29

7:34 pm - 9:20 pm

CHS

MIA

1h 46mnonstop

10:15 pm - 11:59 pm

MIA

CHS

1h 44mnonstop

$217American Airlines

Tue, Jun 9 - Tue, Jun 16

8:03 pm - 8:26 pm

MYR

EYW

24h 23m

1 stop

1:14 pm - 11:39 am

EYW

MYR

22h 25m

1 stop

$222Multiple Airlines

Sat, Jun 6 - Tue, Jun 16

3:00 pm - 9:20 pm

CHS

MIA

6h 20m

1 stop

1:45 pm - 8:40 pm

MIA

CHS

6h 55m

1 stop

$227Southwest

Wed, Jul 22 - Wed, Jul 29

8:20 am - 2:25 pm

CHS

MIA

6h 05m

1 stop

7:40 am - 4:10 pm

MIA

CHS

8h 30m

2 stops

$232Southwest

Wed, Jul 22 - Wed, Jul 29

8:03 pm - 8:26 pm

MYR

EYW

24h 23m

1 stop

11:04 am - 2:30 pm

EYW

MYR

27h 26m

1 stop

$233Multiple Airlines

Sat, Jun 6 - Thu, Jun 11

Frontier flights from South Carolina to Florida Keys

Our best Frontier deals on South Carolina to Florida Keys flight tickets

Frontier

Jul 14

CLT1:00 pmCharlotte Douglas

7h 33m

1 stop

MIA8:33 pmMiami

Jul 21

MIA2:53 pmMiami

2h 19m

CLT5:12 pmCharlotte Douglas

$172

Frontier

Jun 9

CLT10:20 pmCharlotte Douglas

2h 09m

MIA12:29 amMiami

Jun 10

MIA7:00 amMiami

2h 16m

CLT9:16 amCharlotte Douglas

$173

Frontier

Jun 23

CLT10:20 pmCharlotte Douglas

2h 09m

MIA12:29 amMiami

Jun 30

MIA7:00 amMiami

2h 16m

CLT9:16 amCharlotte Douglas

$174

American Airlines flights from South Carolina to Florida Keys

Our best American Airlines deals on South Carolina to Florida Keys flight tickets

American Airlines

Jul 22

CHS6:00 amCharleston

1h 43m

MIA7:43 amMiami

Jul 29

MIA5:00 pmMiami

1h 51m

CHS6:51 pmCharleston

$207

American Airlines

Jun 9

CHS7:34 pmCharleston

1h 46m

MIA9:20 pmMiami

Jun 16

MIA10:15 pmMiami

1h 44m

CHS11:59 pmCharleston

$217

American Airlines

Jun 6

CAE6:00 amColumbia Metropolitan

2h 05m

MIA8:05 amMiami

Jun 20

MIA9:45 pmMiami

2h 09m

CAE11:54 pmColumbia Metropolitan

$221

momondo Fare Finder

Use the filters below to find and compare flights from South Carolina to Florida Keys that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Wed 5/27

4:34 pm-11:25 am

1 stop18h 51m

Key West

Tue 6/2

1:14 pm-12:50 pm

1 stop23h 36m

$156

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Sat 9/26

6:00 am-9:24 am

1 stop3h 24m

Key West

Sat 10/3

10:04 am-1:24 pm

1 stop3h 20m

$164

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Tue 7/14

1:00 pm-8:33 pm

1 stop7h 33m

Miami

Tue 7/21

2:53 pm-5:12 pm

Nonstop2h 19m

$172

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Tue 6/9

10:20 pm-12:29 am

Nonstop2h 09m

Miami

Wed 6/10

7:00 am-9:16 am

Nonstop2h 16m

$173

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Wed 7/22

6:00 am-7:43 am

Nonstop1h 43m

Miami

Wed 7/29

5:00 pm-6:51 pm

Nonstop1h 51m

$207

Quickest round-trip

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Tue 6/9

7:34 pm-9:20 pm

Nonstop1h 46m

Miami

Tue 6/16

10:15 pm-11:59 pm

Nonstop1h 44m

$217

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sat 6/6

8:03 pm-8:26 pm

1 stop24h 23m

Key West

Tue 6/16

1:14 pm-11:39 am

1 stop22h 25m

$222

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Wed 7/22

3:00 pm-9:20 pm

1 stop6h 20m

Miami

Wed 7/29

1:45 pm-8:40 pm

1 stop6h 55m

$227

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Wed 7/22

8:20 am-2:25 pm

1 stop6h 05m

Miami

Wed 7/29

7:40 am-4:10 pm

2 stops8h 30m

$232

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sat 6/6

8:03 pm-8:26 pm

1 stop24h 23m

Key West

Thu 6/11

11:04 am-2:30 pm

1 stop27h 26m

$233

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Carolina to Florida Keys

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Florida Keys?

The month of September is another great option to travel to Florida Keys, with average flight prices from South Carolina averaging around $65.

What is the cheapest day to depart on your flight to Florida Keys?

The cheapest day to depart from South Carolina to Florida Keys is on a Friday when prices can be found for as low as $489. The most expensive day to fly to Florida Keys is Monday, with ticket prices averaging around $565.

What is the cheapest time of day to depart on your flight to Florida Keys?

According to our data, the cheapest time of day to fly to Florida Keys is in the afternoon. momondo users have found flights departing from South Carolina to Florida Keys in the afternoon for as low as $287. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights in the morning are often more expensive with an average ticket price of $529.

How far in advance should I book a flight from South Carolina to Florida Keys?

You are more likely to see cheaper flights to Florida Keys from South Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Florida Keys for around $308 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Florida Keys from South Carolina for as low as $247 on momondo.

Can stopping save me money on South Carolina to Florida Keys flights?

No. A direct flight is the cheapest option for a flight between South Carolina to Florida Keys.

Cheap South Carolina to Florida Keys flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Florida Keys

Fastest flight time	1h 32m
Direct flights	Every day
Airports in Florida Keys	3 airports

The fastest flight from South Carolina to Florida Keys takes 1h 32m

Direct flights go from South Carolina to Florida Keys every day.

There are 3 airports in Florida Keys. From South Carolina there are direct flights to Miami (MIA).

Search flight deals

Frequently asked questions about flying from South Carolina to Florida Keys

When did momondo last update prices for flights from South Carolina to Florida Keys?
Prices for flights from South Carolina to Florida Keys are refreshed on a daily basis.
How many operators does momondo search for flights from South Carolina to Florida Keys?
There are 8 operators available for flights from South Carolina to Florida Keys as of May 2026.
How old do you have to be to fly from South Carolina to Florida Keys?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Florida Keys.
What documentation or ID do you need to fly to Florida Keys?
The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular plane model from South Carolina to Florida Keys?
Based on momondo bookings for flights between South Carolina and Florida Keys, the leading plane model is Airbus A220-300, making up 19.02% of the total bookings. Other popular models include Canadair (Bombardier) Regional Jet 900 with 11.09%, Airbus A320-100/200 with 11.05%, and Embraer 175 with 10.58%.

Best airlines flying from South Carolina to Florida Keys

Compare and see reviews for airlines that fly from South Carolina to Florida Keys with momondo

Airline	Rating	Free Cancellation	Price
Breeze Airways	PriceFrom $106	Free Cancellation	Rating 8.1 283 reviews	Search Breeze Airways flights
Delta	PriceFrom $125	Free Cancellation	Rating 7.9 8,456 reviews	Search Delta flights
American Airlines	PriceFrom $268	Free Cancellation	Rating 7.1 11,667 reviews	Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Florida Keys?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Florida Keys from South Carolina.

Can I find flights from South Carolina to Florida Keys with flexible booking policies on momondo?

All flight searches from South Carolina to Florida Keys on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from South Carolina to Florida Keys?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Florida Keys.

I’m not ready to book a flight from South Carolina to Florida Keys right now. Can momondo alert me if prices change?

Yes. momondo can track prices for South Carolina to Florida Keys flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.