What airlines fly to Florida Keys?

American Airlines, Delta and Breeze Airways are the top three most popular airlines that fly to Florida Keys from South Carolina according to our data. American Airlines is the first choice among our users, with 58% of people opting to fly with this airline when traveling to Florida Keys. Keep in mind that there are 4 different airlines that fly to Florida Keys on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from South Carolina to Florida Keys?

Southwest, Breeze Airways, and Frontier are the most popular carriers operating from South Carolina to Florida Keys

How many flights depart from South Carolina to Florida Keys on average per week?

As of August 2026, there are 216 flights per week flying from South Carolina to Florida Keys. The most common day of the week flights depart is Mon, with 18% of flights taking off on this day.

How long is the flight from South Carolina to Florida Keys?

On average, it takes 13h 55m to fly from South Carolina to Florida Keys if you fly out of Myrtle Beach (the most popular airport in South Carolina) and into Copenhagen (the most popular airport in Florida Keys). If you’re flying out of Charleston and into Copenhagen, then the flight time is around 17h 06m.

When did momondo last update prices for flights from South Carolina to Florida Keys?

Prices for flights from South Carolina to Florida Keys are refreshed on a daily basis.

How many operators does momondo search for flights from South Carolina to Florida Keys?

There are 7 operators available for flights from South Carolina to Florida Keys as of August 2026.

How old do you have to be to fly from South Carolina to Florida Keys?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Florida Keys.

What documentation or ID do you need to fly to Florida Keys?

The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$50 Cheap Flights from South Carolina to Florida Keys in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Carolina to Florida Keys

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:00 am - 9:24 amCHS Charleston-EYW Key West

3h 24m1 stop Tampa

10:04 am - 1:24 pmEYW Key West-CHS Charleston

3h 20m1 stop Tampa

$83Breeze Airways

Wed, Sep 9 - Wed, Sep 16

6:00 am - 9:24 amCHS Charleston-EYW Key West

3h 24m1 stop Tampa

10:04 am - 1:24 pmEYW Key West-CHS Charleston

3h 20m1 stop Tampa

$84Breeze Airways

Wed, Sep 9 - Wed, Sep 16

7:27 pm - 9:38 pmCLT Charlotte Douglas-MIA Miami

2h 11mnonstop

3:59 pm - 6:22 pmMIA Miami-CLT Charlotte Douglas

2h 23mnonstop

$129Frontier

Sat, Sep 12 - Sat, Sep 19

9:59 pm - 12:09 amCLT Charlotte Douglas-MIA Miami

2h 10mnonstop

6:54 pm - 9:14 pmMIA Miami-CLT Charlotte Douglas

2h 20mnonstop

$132Frontier

Fri, Sep 18 - Tue, Sep 22

6:00 am - 9:24 amCHS Charleston-EYW Key West

3h 24m1 stop Tampa

12:53 pm - 4:03 pmEYW Key West-CHS Charleston

27h 10m2 stops Tampa St. Petersburg Fort Lauderdale

$171Multiple Airlines

Wed, Sep 9 - Wed, Sep 16

6:00 am - 9:24 amCHS Charleston-EYW Key West

3h 24m1 stop Tampa

12:53 pm - 4:03 pmEYW Key West-CHS Charleston

27h 10m2 stops Tampa St. Petersburg Fort Lauderdale

$173Multiple Airlines

Wed, Sep 9 - Wed, Sep 16

5:20 am - 7:20 amCLT Charlotte Douglas-MIA Miami

2h 00mnonstop

6:48 pm - 8:59 pmMIA Miami-CLT Charlotte Douglas

2h 11mnonstop

$199American Airlines

Sat, Sep 26 - Wed, Sep 30

1:30 pm - 3:34 pmCLT Charlotte Douglas-MIA Miami

2h 04mnonstop

9:59 am - 12:10 pmMIA Miami-CLT Charlotte Douglas

2h 11mnonstop

$199American Airlines

Sat, Sep 19 - Sat, Sep 26

2:25 pm - 7:05 pmCLT Charlotte Douglas-MIA Miami

4h 40m1 stop Atlanta Hartsfield-Jackson

8:25 am - 1:30 pmMIA Miami-CLT Charlotte Douglas

5h 05m1 stop Atlanta Hartsfield-Jackson

$219Delta

Tue, Sep 22 - Tue, Sep 29

6:40 am - 1:05 pmCLT Charlotte Douglas-MIA Miami

6h 25m1 stop Atlanta Hartsfield-Jackson

4:35 pm - 11:59 pmMIA Miami-CLT Charlotte Douglas

7h 24m1 stop Atlanta Hartsfield-Jackson

$219Delta

Tue, Sep 22 - Tue, Sep 29

Cheap last minute flights

Enter your travel dates to find the best prices.

6:48 pm - 9:05 pmCLT Charlotte Douglas-MIA Miami

2h 17mnonstop

2:53 pm - 5:12 pmMIA Miami-CLT Charlotte Douglas

2h 19mnonstop

$129Frontier

Wed, Aug 12 - Sat, Aug 15

6:48 pm - 9:05 pmCLT Charlotte Douglas-MIA Miami

2h 17mnonstop

2:53 pm - 5:12 pmMIA Miami-CLT Charlotte Douglas

2h 19mnonstop

$138Frontier

Thu, Aug 13 - Sat, Aug 15

12:24 pm - 11:25 amCLT Charlotte Douglas-EYW Key West

23h 01m1 stop Orlando

12:07 pm - 8:01 amEYW Key West-CLT Charlotte Douglas

19h 54m1 stop Orlando

$279Multiple Airlines

Sat, Aug 15 - Mon, Aug 17

7:45 pm - 9:52 pmCLT Charlotte Douglas-MIA Miami

2h 07mnonstop

9:07 am - 11:20 amMIA Miami-CLT Charlotte Douglas

2h 13mnonstop

$289American Airlines

Fri, Aug 14 - Tue, Sep 8

4:35 pm - 6:50 pmCLT Charlotte Douglas-MIA Miami

2h 15mnonstop

8:39 am - 10:49 amMIA Miami-CLT Charlotte Douglas

2h 10mnonstop

$299American Airlines

Sat, Aug 15 - Sat, Aug 22

8:10 am - 2:54 pmCLT Charlotte Douglas-MIA Miami

6h 44m1 stop Atlanta Hartsfield-Jackson

7:18 am - 1:30 pmMIA Miami-CLT Charlotte Douglas

6h 12m1 stop Atlanta Hartsfield-Jackson

$309Delta

Fri, Aug 14 - Tue, Sep 8

8:05 am - 2:54 pmCLT Charlotte Douglas-MIA Miami

6h 49m1 stop Chicago O'Hare Intl

8:45 am - 4:55 pmMIA Miami-CLT Charlotte Douglas

8h 10m1 stop Newark

$317United Airlines

Wed, Aug 12 - Wed, Aug 19

1:13 pm - 6:42 pmCHS Charleston-MIA Miami

5h 29m1 stop Atlanta Hartsfield-Jackson

8:25 am - 1:11 pmMIA Miami-CHS Charleston

4h 46m1 stop Atlanta Hartsfield-Jackson

$318Delta

Sat, Aug 15 - Fri, Aug 21

4:04 pm - 11:25 amCHS Charleston-EYW Key West

19h 21m1 stop Orlando

12:05 pm - 8:45 amEYW Key West-CHS Charleston

20h 40m1 stop Orlando

$324Breeze Airways

Wed, Aug 12 - Thu, Aug 20

2:58 pm - 11:27 amMYR Myrtle Beach Intl-EYW Key West

20h 29m1 stop Orlando

1:14 pm - 11:39 amEYW Key West-MYR Myrtle Beach Intl

22h 25m1 stop Tampa

$364Breeze Airways

Thu, Aug 13 - Tue, Aug 18

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Southwest flights from South Carolina to Florida Keys

Our best Southwest deals on South Carolina to Florida Keys flight tickets

Southwest

Nov 4

CHS1:30 pmCharleston

8h 40m

2 stops

MIA10:10 pmMiami

Nov 10

MIA6:30 amMiami

6h 15m

1 stop

CHS12:45 pmCharleston

$246

Southwest

Nov 4

CHS1:30 pmCharleston

8h 40m

2 stops

MIA10:10 pmMiami

Nov 10

MIA6:50 amMiami

9h 40m

2 stops

CHS4:30 pmCharleston

$251

Southwest

Dec 8

MYR3:25 pmMyrtle Beach Intl

6h 45m

2 stops

MIA10:10 pmMiami

Dec 15

MIA11:35 amMiami

6h 50m

1 stop

MYR6:25 pmMyrtle Beach Intl

$264

American Airlines flights from South Carolina to Florida Keys

Our best American Airlines deals on South Carolina to Florida Keys flight tickets

American Airlines

Oct 1

MYR7:25 pmMyrtle Beach Intl

4h 34m

1 stop

MIA11:59 pmMiami

Oct 7

MIA5:32 pmMiami

4h 43m

1 stop

MYR10:15 pmMyrtle Beach Intl

$257

American Airlines

Sep 14

MYR5:45 pmMyrtle Beach Intl

6h 14m

1 stop

MIA11:59 pmMiami

Sep 18

MIA5:20 pmMiami

5h 33m

1 stop

MYR10:53 pmMyrtle Beach Intl

$292

American Airlines

Nov 6

CHS7:27 amCharleston

1h 46m

MIA9:13 amMiami

Nov 9

MIA10:06 pmMiami

1h 53m

CHS11:59 pmCharleston

$297

momondo Fare Finder

Use the filters below to find and compare flights from South Carolina to Florida Keys that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonKey West

CHS Charleston - EYW Key West

CHSEYW

Charleston

Wed 9/9

6:00 am-9:24 am

1 stop3h 24m

Key West

Wed 9/16

10:04 am-1:24 pm

1 stop3h 20m

$83

CharlestonKey West

CHS Charleston - EYW Key West

CHSEYW

Charleston

Wed 9/9

6:00 am-9:24 am

1 stop3h 24m

Key West

Wed 9/16

10:04 am-1:24 pm

1 stop3h 20m

$84

CharlotteMiami

CLT Charlotte Douglas - MIA Miami

CLTMIA

Charlotte Douglas

Sat 9/12

7:27 pm-9:38 pm

Nonstop2h 11m

Miami

Sat 9/19

3:59 pm-6:22 pm

Nonstop2h 23m

$129

CharlotteMiami

CLT Charlotte Douglas - MIA Miami

CLTMIA

Charlotte Douglas

Fri 9/18

9:59 pm-12:09 am

Nonstop2h 10m

Miami

Tue 9/22

6:54 pm-9:14 pm

Nonstop2h 20m

$132

CharlestonKey West

CHS Charleston - EYW Key West

CHSEYW

Charleston

Wed 9/9

6:00 am-9:24 am

1 stop3h 24m

Key West

Wed 9/16

12:53 pm-4:03 pm

2 stops27h 10m

$171

CharlestonKey West

CHS Charleston - EYW Key West

CHSEYW

Charleston

Wed 9/9

6:00 am-9:24 am

1 stop3h 24m

Key West

Wed 9/16

12:53 pm-4:03 pm

2 stops27h 10m

$173

Quickest round-trip

CharlotteMiami

CLT Charlotte Douglas - MIA Miami

CLTMIA

Charlotte Douglas

Sat 9/26

5:20 am-7:20 am

Nonstop2h 00m

Miami

Wed 9/30

6:48 pm-8:59 pm

Nonstop2h 11m

$199

CharlotteMiami

CLT Charlotte Douglas - MIA Miami

CLTMIA

Charlotte Douglas

Sat 9/19

1:30 pm-3:34 pm

Nonstop2h 04m

Miami

Sat 9/26

9:59 am-12:10 pm

Nonstop2h 11m

$199

CharlotteMiami

CLT Charlotte Douglas - MIA Miami

CLTMIA

Charlotte Douglas

Tue 9/22

2:25 pm-7:05 pm

1 stop4h 40m

Miami

Tue 9/29

8:25 am-1:30 pm

1 stop5h 05m

$219

CharlotteMiami

CLT Charlotte Douglas - MIA Miami

CLTMIA

Charlotte Douglas

Tue 9/22

6:40 am-1:05 pm

1 stop6h 25m

Miami

Tue 9/29

4:35 pm-11:59 pm

1 stop7h 24m

$219

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Carolina to Florida Keys

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Florida Keys?

The month of September is another great option to travel to Florida Keys, with average flight prices from South Carolina averaging around $352.

What is the cheapest day to depart on your flight to Florida Keys?

The cheapest day to depart from South Carolina to Florida Keys is on a Friday when prices can be found for as low as $512. The most expensive day to fly to Florida Keys is Sunday, with ticket prices averaging around $605.

What is the cheapest time of day to depart on your flight to Florida Keys?

According to our data, the cheapest time of day to fly to Florida Keys is in the afternoon. momondo users have found flights departing from South Carolina to Florida Keys in the afternoon for as low as $287. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights in the morning are often more expensive with an average ticket price of $556.

How far in advance should I book a flight from South Carolina to Florida Keys?

You are more likely to see cheaper flights to Florida Keys from South Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Florida Keys for around $324 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Florida Keys from South Carolina for as low as $265 on momondo.

Can stopping save me money on South Carolina to Florida Keys flights?

No. A direct flight is the cheapest option for a flight between South Carolina to Florida Keys.

Cheap South Carolina to Florida Keys flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Florida Keys

Fastest flight time	1h 32m
Direct flights	Every day
Airports in Florida Keys	3 airports

The fastest flight from South Carolina to Florida Keys takes 1h 32m

Direct flights go from South Carolina to Florida Keys every day.

There are 3 airports in Florida Keys. From South Carolina there are direct flights to Miami (MIA).

Search flight deals

Frequently asked questions about flying from South Carolina to Florida Keys

When did momondo last update prices for flights from South Carolina to Florida Keys?
Prices for flights from South Carolina to Florida Keys are refreshed on a daily basis.
How many operators does momondo search for flights from South Carolina to Florida Keys?
There are 7 operators available for flights from South Carolina to Florida Keys as of August 2026.
How old do you have to be to fly from South Carolina to Florida Keys?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Florida Keys.
What documentation or ID do you need to fly to Florida Keys?
The required travel and health documents for your Florida Keys trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florida Keys. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular plane model from South Carolina to Florida Keys?
Based on momondo bookings for flights between South Carolina and Florida Keys, the leading plane model is Airbus A220-300, making up 23.62% of the total bookings. Other popular models include Canadair (Bombardier) Regional Jet 900 with 11.23%, Airbus A320-100/200 with 10.01%, and Embraer 175 with 9.85%.

Best airlines flying from South Carolina to Florida Keys

Compare and see reviews for airlines that fly from South Carolina to Florida Keys with momondo

Airline	Rating	Free Cancellation	Price
Allegiant Air	PriceFrom $76	Free Cancellation	Rating 7.3 679 reviews	Search Allegiant Air flights
Breeze Airways	PriceFrom $106	Free Cancellation	Rating 8.2 305 reviews	Search Breeze Airways flights
Delta	PriceFrom $125	Free Cancellation	Rating 7.8 8,505 reviews	Search Delta flights
American Airlines	PriceFrom $268	Free Cancellation	Rating 7.1 11,904 reviews	Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Florida Keys?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Florida Keys from South Carolina.

Can I find flights from South Carolina to Florida Keys with flexible booking policies on momondo?

All flight searches from South Carolina to Florida Keys on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from South Carolina to Florida Keys?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from South Carolina to Florida Keys.

I’m not ready to book a flight from South Carolina to Florida Keys right now. Can momondo alert me if prices change?

Yes. momondo can track prices for South Carolina to Florida Keys flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.