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Cheap flights from Santiago to St. Louis from $499

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to St. Louis departing on 6/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Santiago to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:30 pm - 10:53 pm
SCL
-
STL
27h 23m
1 stop
American Airlines Logo
5:18 am - 6:50 am
STL
-
SCL
24h 32m
1 stop
$973American Airlines
Wed, Jul 15 - Wed, Aug 5
American Airlines Logo
8:30 pm - 10:53 pm
SCL
-
STL
27h 23m
1 stop
American Airlines Logo
5:18 am - 6:50 am
STL
-
SCL
24h 32m
1 stop
$974American Airlines
Wed, Jul 15 - Wed, Aug 5
American Airlines Logo
8:30 pm - 10:24 am
SCL
-
STL
14h 54m
1 stop
American Airlines Logo
5:18 am - 6:50 am
STL
-
SCL
24h 32m
1 stop
$975American Airlines
Wed, Jul 15 - Wed, Aug 5
American Airlines Logo
8:30 pm - 10:24 am
SCL
-
STL
14h 54m
1 stop
American Airlines Logo
10:14 am - 6:50 am
STL
-
SCL
19h 36m
2 stops
$978American Airlines
Wed, Jul 15 - Wed, Aug 5
American Airlines Logo
8:30 pm - 5:22 pm
SCL
-
STL
21h 52m
2 stops
American Airlines Logo
10:16 am - 6:50 am
STL
-
SCL
19h 34m
2 stops
$979American Airlines
Wed, Jul 15 - Wed, Aug 5
American Airlines Logo
8:30 pm - 10:53 pm
SCL
-
STL
27h 23m
1 stop
American Airlines Logo
10:16 am - 6:50 am
STL
-
SCL
19h 34m
2 stops
$980American Airlines
Wed, Jul 15 - Wed, Aug 5
American Airlines Logo
8:30 pm - 10:24 am
SCL
-
STL
14h 54m
1 stop
American Airlines Logo
11:48 am - 6:50 am
STL
-
SCL
18h 02m
1 stop
$981American Airlines
Wed, Jul 15 - Wed, Aug 5
American Airlines Logo
8:30 pm - 2:50 pm
SCL
-
STL
19h 20m
2 stops
American Airlines Logo
1:01 pm - 6:50 am
STL
-
SCL
16h 49m
2 stops
$985American Airlines
Wed, Jul 15 - Wed, Aug 5
LATAM Airlines Logo
10:30 am - 9:44 am
SCL
-
STL
24h 14m
2 stops
LATAM Airlines Logo
1:22 pm - 6:55 am
STL
-
SCL
16h 33m
2 stops
$1,004LATAM Airlines
Wed, Jun 3 - Wed, Jul 15
Delta Logo
10:55 pm - 5:00 pm
SCL
-
STL
19h 05m
1 stop
Delta Logo
5:19 pm - 2:05 pm
STL
-
SCL
19h 46m
2 stops
$1,016Delta
Wed, Jul 1 - Wed, Jul 8

American Airlines flights from Santiago to St. Louis

Our best American Airlines deals on Santiago to St. Louis flight tickets
American Airlines
Jul 15
SCL8:30 pmSantiago Arturo Merino Benitez
27h 23m
1 stop
STL10:53 pmLambert-St Louis
Aug 5
STL5:18 amLambert-St Louis
24h 32m
1 stop
SCL6:50 amSantiago Arturo Merino Benitez
$973
American Airlines
Jul 15
SCL8:30 pmSantiago Arturo Merino Benitez
27h 23m
1 stop
STL10:53 pmLambert-St Louis
Aug 5
STL5:18 amLambert-St Louis
24h 32m
1 stop
SCL6:50 amSantiago Arturo Merino Benitez
$974
American Airlines
Jul 15
SCL8:30 pmSantiago Arturo Merino Benitez
14h 54m
1 stop
STL10:24 amLambert-St Louis
Aug 5
STL5:18 amLambert-St Louis
24h 32m
1 stop
SCL6:50 amSantiago Arturo Merino Benitez
$975

LATAM Airlines flights from Santiago to St. Louis

Our best LATAM Airlines deals on Santiago to St. Louis flight tickets
LATAM Airlines
Jun 3
SCL10:30 amSantiago Arturo Merino Benitez
24h 14m
2 stops
STL9:44 amLambert-St Louis
Jul 15
STL1:22 pmLambert-St Louis
16h 33m
2 stops
SCL6:55 amSantiago Arturo Merino Benitez
$1,004
LATAM Airlines
Jun 3
SCL11:00 pmSantiago Arturo Merino Benitez
19h 56m
2 stops
STL5:56 pmLambert-St Louis
Jul 15
STL1:22 pmLambert-St Louis
16h 33m
2 stops
SCL6:55 amSantiago Arturo Merino Benitez
$1,027
LATAM Airlines
May 21
SCL8:30 amSantiago Arturo Merino Benitez
26h 14m
3 stops
STL9:44 amLambert-St Louis
May 28
STL1:27 pmLambert-St Louis
16h 28m
2 stops
SCL6:55 amSantiago Arturo Merino Benitez
$1,247

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 7, 2026.
Use the filters below to find and compare flights from Santiago to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 7/15

8:30 pm-10:53 pm

1 stop27h 23m

Lambert-St Louis

Wed 8/5

5:18 am-6:50 am

1 stop24h 32m

$973

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 7/15

8:30 pm-10:53 pm

1 stop27h 23m

Lambert-St Louis

Wed 8/5

5:18 am-6:50 am

1 stop24h 32m

$974

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 7/15

8:30 pm-10:24 am

1 stop14h 54m

Lambert-St Louis

Wed 8/5

5:18 am-6:50 am

1 stop24h 32m

$975

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 7/15

8:30 pm-10:24 am

1 stop14h 54m

Lambert-St Louis

Wed 8/5

10:14 am-6:50 am

2 stops19h 36m

$978

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 7/15

8:30 pm-5:22 pm

2 stops21h 52m

Lambert-St Louis

Wed 8/5

10:16 am-6:50 am

2 stops19h 34m

$979

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 7/15

8:30 pm-10:53 pm

1 stop27h 23m

Lambert-St Louis

Wed 8/5

10:16 am-6:50 am

2 stops19h 34m

$980
Quickest round-trip

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 7/15

8:30 pm-10:24 am

1 stop14h 54m

Lambert-St Louis

Wed 8/5

11:48 am-6:50 am

1 stop18h 02m

$981

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 7/15

8:30 pm-2:50 pm

2 stops19h 20m

Lambert-St Louis

Wed 8/5

1:01 pm-6:50 am

2 stops16h 49m

$985

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 6/3

10:30 am-9:44 am

2 stops24h 14m

Lambert-St Louis

Wed 7/15

1:22 pm-6:55 am

2 stops16h 33m

$1,004

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 7/1

10:55 pm-5:00 pm

1 stop19h 05m

Lambert-St Louis

Wed 7/8

5:19 pm-2:05 pm

2 stops19h 46m

$1,016

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Santiago to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santiago and St. Louis?

What is the cheapest month to fly to St. Louis?

In general, December is the cheapest month to fly from Santiago to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $795. The month of March is another great option to travel to St. Louis, with average flight prices from Santiago averaging around $835.

When to book flights from Santiago to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to St. Louis (SCL to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to St. Louis

Fastest flight time

14h 03m

Direct flights

None
The fastest flight from Santiago to St. Louis takes 14h 03m
There are no direct flights from Santiago to St. Louis. There are no popular flight routes from Santiago to St. Louis.
Search flight deals

Frequently asked questions about flying from Santiago to St. Louis

  • How far is Santiago Arturo Merino Benitez to Lambert-St Louis by plane?

    Santiago Arturo Merino Benitez and Lambert-St Louis are 5131.6 mi apart from one another. By plane, this route typically takes 14h 03m.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to Lambert-St Louis Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to Lambert-St Louis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Santiago to St. Louis?

Best airlines flying from Santiago to St. Louis

Compare and see reviews for airlines that fly from Santiago to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $542Free CancellationRating
7.9
8,387 reviews
Search Delta flights
American AirlinesPriceFrom $948Free CancellationRating
7.1
11,546 reviews
Search American Airlines flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
St. Peters
Collinsville
Wentzville
Alton
Fenton
Farmington
Clayton
Festus
Eureka
Edwardsville
Litchfield
Shrewsbury
Grafton

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to St. Louis?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to St. Louis. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to St. Louis with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Santiago to St. Louis flights to just show those with flexible booking policies.

How can momondo help me find flights from Santiago to St. Louis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to St. Louis from Santiago.

I’m not ready to book a flight from Santiago to St. Louis right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to St. Louis from Santiago. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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