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Cheap flights from Santiago to St. Louis from $385

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to St. Louis departing on 8/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Santiago to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:30 pm - 11:49 pm
SCL
-
STL
32h 19m
2 stops
Multiple Airlines Logo
3:34 pm - 1:35 pm
STL
-
SCL
45h 01m
3 stops
$986Multiple Airlines
Wed, Jul 1 - Wed, Jul 8
Multiple Airlines Logo
11:00 pm - 11:59 pm
SCL
-
STL
25h 59m
3 stops
Multiple Airlines Logo
7:03 pm - 6:00 am
STL
-
SCL
57h 57m
3 stops
$1,023Multiple Airlines
Wed, Jul 15 - Wed, Aug 5
Air Canada Logo
8:55 pm - 4:30 pm
SCL
-
STL
21h 35m
1 stop
Air Canada Logo
4:15 pm - 11:15 am
STL
-
SCL
16h 00m
1 stop
$1,031Air Canada
Sat, Oct 31 - Wed, Nov 4
American Airlines Logo
9:00 pm - 10:24 am
SCL
-
STL
14h 24m
1 stop
American Airlines Logo
6:08 pm - 7:50 am
STL
-
SCL
11h 42m
1 stop
$1,035American Airlines
Mon, Aug 3 - Mon, Oct 5
Multiple Airlines Logo
12:30 am - 11:57 pm
SCL
-
STL
24h 27m
2 stops
Multiple Airlines Logo
4:19 pm - 11:20 pm
STL
-
SCL
30h 01m
2 stops
$1,039Multiple Airlines
Sun, May 31 - Mon, Jun 8
American Airlines Logo
9:00 pm - 5:08 pm
SCL
-
STL
21h 08m
2 stops
American Airlines Logo
6:08 pm - 7:50 am
STL
-
SCL
11h 42m
1 stop
$1,040American Airlines
Mon, Aug 3 - Mon, Oct 5
Multiple Airlines Logo
12:30 am - 7:23 pm
SCL
-
STL
43h 53m
3 stops
Multiple Airlines Logo
4:19 pm - 2:15 pm
STL
-
SCL
20h 56m
2 stops
$1,056Multiple Airlines
Sun, May 31 - Mon, Jun 8
LATAM Airlines Logo
11:05 pm - 8:19 am
SCL
-
STL
34h 14m
2 stops
LATAM Airlines Logo
12:52 pm - 6:55 am
STL
-
SCL
17h 03m
2 stops
$1,063LATAM Airlines
Wed, Jul 15 - Wed, Aug 5
Delta Logo
8:40 pm - 2:33 pm
SCL
-
STL
18h 53m
1 stop
Delta Logo
7:00 am - 7:15 am
STL
-
SCL
23h 15m
1 stop
$1,066Delta
Wed, Aug 12 - Wed, Aug 26
Delta Logo
10:55 pm - 4:52 pm
SCL
-
STL
18h 57m
2 stops
Delta Logo
12:52 pm - 7:15 am
STL
-
SCL
17h 23m
1 stop
$1,084Delta
Tue, Aug 18 - Fri, Aug 28

LATAM Airlines flights from Santiago to St. Louis

Our best LATAM Airlines deals on Santiago to St. Louis flight tickets
LATAM Airlines
Jul 15
SCL11:05 pmSantiago Arturo Merino Benitez
34h 14m
2 stops
STL8:19 amLambert-St Louis
Aug 5
STL12:52 pmLambert-St Louis
17h 03m
2 stops
SCL6:55 amSantiago Arturo Merino Benitez
$1,063
LATAM Airlines
Aug 2
SCL12:40 amSantiago Arturo Merino Benitez
18h 13m
2 stops
STL5:53 pmLambert-St Louis
Oct 5
STL1:30 pmLambert-St Louis
21h 55m
3 stops
SCL1:25 pmSantiago Arturo Merino Benitez
$1,171
LATAM Airlines
Aug 4
SCL7:50 amSantiago Arturo Merino Benitez
17h 08m
2 stops
STL11:58 pmLambert-St Louis
Aug 30
STL12:52 pmLambert-St Louis
23h 33m
3 stops
SCL1:25 pmSantiago Arturo Merino Benitez
$1,221

Copa Airlines flights from Santiago to St. Louis

Our best Copa Airlines deals on Santiago to St. Louis flight tickets
Copa Airlines
May 19
SCL2:22 amSantiago Arturo Merino Benitez
31h 17m
2 stops
STL8:39 amLambert-St Louis
Jun 10
STL6:00 amLambert-St Louis
22h 03m
2 stops
SCL5:03 amSantiago Arturo Merino Benitez
$1,080
Copa Airlines
May 20
SCL11:17 amSantiago Arturo Merino Benitez
22h 22m
2 stops
STL8:39 amLambert-St Louis
Jun 10
STL6:00 amLambert-St Louis
22h 03m
2 stops
SCL5:03 amSantiago Arturo Merino Benitez
$1,088
Copa Airlines
May 19
SCL11:17 amSantiago Arturo Merino Benitez
35h 01m
2 stops
STL9:18 pmLambert-St Louis
Jun 2
STL6:00 amLambert-St Louis
22h 03m
2 stops
SCL5:03 amSantiago Arturo Merino Benitez
$1,093

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 14, 2026.
Use the filters below to find and compare flights from Santiago to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 7/1

4:30 pm-11:49 pm

2 stops32h 19m

Lambert-St Louis

Wed 7/8

3:34 pm-1:35 pm

3 stops45h 01m

$986

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 7/15

11:00 pm-11:59 pm

3 stops25h 59m

Lambert-St Louis

Wed 8/5

7:03 pm-6:00 am

3 stops57h 57m

$1,023

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Sat 10/31

8:55 pm-4:30 pm

1 stop21h 35m

Lambert-St Louis

Wed 11/4

4:15 pm-11:15 am

1 stop16h 00m

$1,031
Quickest round-trip

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Mon 8/3

9:00 pm-10:24 am

1 stop14h 24m

Lambert-St Louis

Mon 10/5

6:08 pm-7:50 am

1 stop11h 42m

$1,035

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Sun 5/31

12:30 am-11:57 pm

2 stops24h 27m

Lambert-St Louis

Mon 6/8

4:19 pm-11:20 pm

2 stops30h 01m

$1,039

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Mon 8/3

9:00 pm-5:08 pm

2 stops21h 08m

Lambert-St Louis

Mon 10/5

6:08 pm-7:50 am

1 stop11h 42m

$1,040

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Sun 5/31

12:30 am-7:23 pm

3 stops43h 53m

Lambert-St Louis

Mon 6/8

4:19 pm-2:15 pm

2 stops20h 56m

$1,056

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 7/15

11:05 pm-8:19 am

2 stops34h 14m

Lambert-St Louis

Wed 8/5

12:52 pm-6:55 am

2 stops17h 03m

$1,063

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 8/12

8:40 pm-2:33 pm

1 stop18h 53m

Lambert-St Louis

Wed 8/26

7:00 am-7:15 am

1 stop23h 15m

$1,066

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Tue 8/18

10:55 pm-4:52 pm

2 stops18h 57m

Lambert-St Louis

Fri 8/28

12:52 pm-7:15 am

1 stop17h 23m

$1,084

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Santiago to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santiago and St. Louis?

What is the cheapest month to fly to St. Louis?

In general, December is the cheapest month to fly from Santiago to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $795. The month of March is another great option to travel to St. Louis, with average flight prices from Santiago averaging around $835.

Can stopping save me money on Santiago to St. Louis flights?

You could potentially save up to 34% on your flight if you consider stops on a Santiago to St. Louis flight.

When to book flights from Santiago to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to St. Louis (SCL to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to St. Louis

Fastest flight time

16h 33m

Direct flights

None
The fastest flight from Santiago to St. Louis takes 16h 33m
There are no direct flights from Santiago to St. Louis. There are no popular flight routes from Santiago to St. Louis.
Search flight deals

Frequently asked questions about flying from Santiago to St. Louis

  • How far is Santiago Arturo Merino Benitez to Lambert-St Louis by plane?

    Santiago Arturo Merino Benitez and Lambert-St Louis are 5131.6 mi apart from one another. By plane, this route typically takes 16h 33m.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to Lambert-St Louis Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to Lambert-St Louis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Santiago to St. Louis?

Best airlines flying from Santiago to St. Louis

Compare and see reviews for airlines that fly from Santiago to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $542Free CancellationRating
7.9
8,454 reviews
Search Delta flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
St. Peters
Collinsville
Alton
Wentzville
Fenton
Farmington
Festus
Clayton
Eureka
Litchfield
Edwardsville
Shrewsbury
Grafton

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to St. Louis?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to St. Louis. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to St. Louis with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Santiago to St. Louis flights to just show those with flexible booking policies.

How can momondo help me find flights from Santiago to St. Louis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to St. Louis from Santiago.

I’m not ready to book a flight from Santiago to St. Louis right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to St. Louis from Santiago. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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