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Cheap flights from Santiago to St. Louis from $442

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santiago to St. Louis departing on 1/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
3:32 am - 10:33 pmSCL-STL
21h 01m2 stops
Multiple Airlines Logo
6:00 am - 3:58 amSTL-SCL
19h 58m2 stops
$694Multiple Airlines
Find Deal
Tue, Mar 10 - Mon, Mar 23
Multiple Airlines Logo
5:44 am - 10:33 pmSCL-STL
18h 49m2 stops
Multiple Airlines Logo
6:00 am - 3:58 amSTL-SCL
19h 58m2 stops
$717Multiple Airlines
Find Deal
Wed, Mar 11 - Mon, Mar 23
LATAM Airlines Logo
11:25 pm - 5:53 pmSCL-STL
20h 28m2 stops
LATAM Airlines Logo
12:22 pm - 7:00 amSTL-SCL
16h 38m2 stops
$740LATAM Airlines
Find Deal
Wed, Mar 11 - Mon, Mar 23
LATAM Airlines Logo
11:25 pm - 5:53 pmSCL-STL
20h 28m2 stops
LATAM Airlines Logo
12:22 pm - 7:40 amSTL-SCL
17h 18m1 stop
$753LATAM Airlines
Find Deal
Wed, Mar 11 - Mon, Mar 23
Delta Logo
11:55 pm - 5:07 pmSCL-STL
19h 12m2 stops
Delta Logo
10:02 am - 7:00 amSTL-SCL
18h 58m2 stops
$755Delta
Find Deal
Thu, Mar 12 - Tue, Mar 24
Delta Logo
8:50 am - 11:42 pmSCL-STL
16h 52m2 stops
Delta Logo
5:00 pm - 7:40 amSTL-SCL
12h 40m1 stop
$756Delta
Find Deal
Tue, Mar 10 - Wed, Mar 25
Delta Logo
8:50 am - 11:42 pmSCL-STL
16h 52m2 stops
Delta Logo
10:02 am - 5:35 amSTL-SCL
17h 33m2 stops
$757Delta
Find Deal
Tue, Mar 10 - Thu, Mar 26
Delta Logo
6:40 am - 11:42 pmSCL-STL
19h 02m2 stops
Delta Logo
12:22 pm - 6:35 amSTL-SCL
16h 13m2 stops
$759Delta
Find Deal
Mon, Mar 9 - Mon, Mar 23
LATAM Airlines Logo
6:30 pm - 8:58 amSCL-STL
17h 28m2 stops
LATAM Airlines Logo
9:47 am - 6:10 amSTL-SCL
17h 23m1 stop
$764LATAM Airlines
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Thu, Dec 25 - Mon, Dec 29
LATAM Airlines Logo
10:25 pm - 11:42 pmSCL-STL
27h 17m2 stops
LATAM Airlines Logo
10:02 am - 6:25 amSTL-SCL
18h 23m2 stops
$765LATAM Airlines
Find Deal
Mon, Mar 9 - Thu, Mar 26

LATAM Airlines flights from Santiago to St. Louis

Our best LATAM Airlines deals on Santiago to St. Louis flight tickets
LATAM Airlines
Mar 11
SCL11:25 pmSantiago Arturo Merino Benitez
20h 28m
2 stops
STL5:53 pmLambert-St Louis
Mar 23
STL12:22 pmLambert-St Louis
16h 38m
2 stops
SCL7:00 amSantiago Arturo Merino Benitez
$740
Find similar
LATAM Airlines
Mar 11
SCL11:25 pmSantiago Arturo Merino Benitez
20h 28m
2 stops
STL5:53 pmLambert-St Louis
Mar 23
STL12:22 pmLambert-St Louis
17h 18m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
$753
Find similar
LATAM Airlines
Dec 25
SCL6:30 pmSantiago Arturo Merino Benitez
17h 28m
2 stops
STL8:58 amLambert-St Louis
Dec 29
STL9:47 amLambert-St Louis
17h 23m
1 stop
SCL6:10 amSantiago Arturo Merino Benitez
$764
Find similar

Delta flights from Santiago to St. Louis

Our best Delta deals on Santiago to St. Louis flight tickets
Delta
Mar 12
SCL10:10 pmSantiago Arturo Merino Benitez
15h 26m
1 stop
STL11:36 amLambert-St Louis
Mar 26
STL10:02 amLambert-St Louis
16h 28m
2 stops
SCL4:30 amSantiago Arturo Merino Benitez
$755
Find similar
Delta
Mar 10
SCL10:10 pmSantiago Arturo Merino Benitez
12h 42m
1 stop
STL8:52 amLambert-St Louis
Mar 25
STL5:00 pmLambert-St Louis
12h 40m
1 stop
SCL7:40 amSantiago Arturo Merino Benitez
$756
Find similar
Delta
Mar 10
SCL10:10 pmSantiago Arturo Merino Benitez
12h 42m
1 stop
STL8:52 amLambert-St Louis
Mar 26
STL7:10 amLambert-St Louis
20h 25m
2 stops
SCL5:35 amSantiago Arturo Merino Benitez
$757
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santiago to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 1, 2025.
Use the filters below to find and compare flights from Santiago to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Tue 3/10

3:32 am-10:33 pm

2 stops21h 01m

Lambert-St Louis

Mon 3/23

6:00 am-3:58 am

2 stops19h 58m

$694

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 3/11

5:44 am-10:33 pm

2 stops18h 49m

Lambert-St Louis

Mon 3/23

6:00 am-3:58 am

2 stops19h 58m

$717

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 3/11

11:25 pm-5:53 pm

2 stops20h 28m

Lambert-St Louis

Mon 3/23

12:22 pm-7:00 am

2 stops16h 38m

$740

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 3/11

11:25 pm-5:53 pm

2 stops20h 28m

Lambert-St Louis

Mon 3/23

12:22 pm-7:40 am

1 stop17h 18m

$753

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 3/12

11:55 pm-5:07 pm

2 stops19h 12m

Lambert-St Louis

Tue 3/24

10:02 am-7:00 am

2 stops18h 58m

$755

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Tue 3/10

8:50 am-11:42 pm

2 stops16h 52m

Lambert-St Louis

Wed 3/25

5:00 pm-7:40 am

1 stop12h 40m

$756

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Tue 3/10

8:50 am-11:42 pm

2 stops16h 52m

Lambert-St Louis

Thu 3/26

10:02 am-5:35 am

2 stops17h 33m

$757

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Mon 3/9

6:40 am-11:42 pm

2 stops19h 02m

Lambert-St Louis

Mon 3/23

12:22 pm-6:35 am

2 stops16h 13m

$759

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 12/25

6:30 pm-8:58 am

2 stops17h 28m

Lambert-St Louis

Mon 12/29

9:47 am-6:10 am

1 stop17h 23m

$764

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Mon 3/9

10:25 pm-11:42 pm

2 stops27h 17m

Lambert-St Louis

Thu 3/26

10:02 am-6:25 am

2 stops18h 23m

$765

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Santiago to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Tuesday when prices can be found for as low as $780. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $1,051. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

When to book flights from Santiago to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Santiago to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santiago to St. Louis (SCL to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santiago to St. Louis

Fastest flight time

14h 28m

Direct flights

None
The fastest flight from Santiago to St. Louis takes 14h 28m
There are no direct flights from Santiago to St. Louis. There are no popular flight routes from Santiago to St. Louis.
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  • How far is Santiago Arturo Merino Benitez to Lambert-St Louis by plane?

    Santiago Arturo Merino Benitez and Lambert-St Louis are 5131.6 mi apart from one another. By plane, this route typically takes 12h 42m.

  • When did momondo last update prices for flights from Santiago Arturo Merino Benitez Airport to Lambert-St Louis Airport?

    Prices for flights from Santiago Arturo Merino Benitez Airport to Lambert-St Louis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santiago Arturo Merino Benitez Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Santiago Arturo Merino Benitez Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santiago Arturo Merino Benitez Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Santiago to St. Louis?

Best airlines flying from Santiago to St. Louis

Compare and see reviews for airlines that fly from Santiago to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $877Free CancellationRating
7.9
8,011 reviews
Search Delta flights
American AirlinesPriceFrom $948Free CancellationRating
7.2
11,039 reviews
Search American Airlines flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
Fenton
Wentzville
Collinsville
St. Peters
Alton
Farmington
Clayton
Festus
Glencoe
Edwardsville
Eureka
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Santiago to St. Louis?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Santiago to St. Louis. momondo saves you time and could save you money on your trip.

Can I find flights from Santiago to St. Louis with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Santiago to St. Louis flights to just show those with flexible booking policies.

How can momondo help me find flights from Santiago to St. Louis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to St. Louis from Santiago.

I’m not ready to book a flight from Santiago to St. Louis right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to St. Louis from Santiago. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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