Cheap flights from San Francisco to Central America from $208

In general, February is the cheapest month to fly from San Francisco to Central America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $558. If you don’t want to visit Central America in February, then you should wait until March to fly from San Francisco, when ticket prices are also cheap, with an average price of $588.

The cheapest day to depart from San Francisco to Central America is on a Monday. Travelers who choose to depart for Central America on a Monday will often find tickets for as low as $647. On the other hand, Tuesday is the most expensive day to depart from San Francisco because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $699.

Our data shows that the cheapest San Francisco to Central America flights are usually those with departure times at noon. Our users have found flights to Central America at noon for as low as $669. Try not to purchase tickets in the evening because they tend to be around $676. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from San Francisco to Panama City Tocumen Intl for the best San Francisco - Central America flight prices

You are more likely to see cheaper flights to Central America from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Central America for around $633 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Central America from San Francisco for as low as $520 on momondo.

There are 4 cabin classes available to choose from on San Francisco to Central America flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Southwest, Alaska Airlines, and JetBlue are the most popular carriers operating from San Francisco to Central America

Avianca, United Airlines and Copa Airlines are the top three most popular airlines that fly to Central America from San Francisco according to our data. Avianca is the first choice among our users, with 64% of people opting to fly with this airline when traveling to Central America. Keep in mind that there are 11 different airlines that fly to Central America on a routine basis, so you have a few additional options to choose from.

As of October 2026, 3 flights take off from San Francisco and land in Central America each day. The most common flight departure time for this route is 11:00PM, with 44% of daily flights taking off in the morning.

As of October 2026, 27 flights take off from San Francisco and land in Central America each week. The most common flight departure day for this route is Wed, with 37% of weekly flights taking off on this day.