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Cheap flights from San Diego to South America from $107

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to South America departing on 8/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Diego to South America

Cheap round-trip flights

Copa Airlines Logo
8:10 pm - 2:15 pmSAN-MDE
15h 05m1 stop
Copa Airlines Logo
10:46 am - 5:03 pmMDE-SAN
9h 17m1 stop
$407Copa Airlines
Find Deal
Wed, Nov 12 - Wed, Nov 19
Spirit Airlines Logo
7:47 pm - 12:23 pmSAN-CTG
14h 36m2 stops
Spirit Airlines Logo
1:29 pm - 11:34 pmCTG-SAN
12h 05m2 stops
$410Spirit Airlines
Find Deal
Mon, Sep 29 - Sat, Oct 4
LATAM Airlines Logo
11:00 am - 6:25 amSAN-LIM
16h 25m2 stops
LATAM Airlines Logo
12:15 am - 3:20 pmLIM-SAN
18h 05m2 stops
$438LATAM Airlines
Find Deal
Mon, Nov 10 - Mon, Nov 17
Delta Logo
9:50 pm - 8:15 pmSAN-LIM
20h 25m2 stops
Delta Logo
12:05 am - 6:10 pmLIM-SAN
20h 05m2 stops
$441Delta
Find Deal
Sun, Sep 21 - Mon, Sep 29
Delta Logo
10:37 am - 10:55 amSAN-BOG
22h 18m2 stops
Delta Logo
1:35 am - 7:27 pmBOG-SAN
19h 52m2 stops
$444Delta
Find Deal
Fri, Sep 5 - Wed, Sep 17
LATAM Airlines Logo
6:25 am - 6:25 amSAN-LIM
22h 00m2 stops
LATAM Airlines Logo
12:00 pm - 10:59 pmLIM-SAN
12h 59m1 stop
$446LATAM Airlines
Find Deal
Wed, Sep 10 - Wed, Sep 17
American Airlines Logo
10:45 pm - 9:17 pmSAN-BOG
20h 32m1 stop
American Airlines Logo
12:25 am - 9:50 pmBOG-SAN
23h 25m1 stop
$451American Airlines
Find Deal
Mon, Sep 22 - Wed, Oct 1
American Airlines Logo
10:45 pm - 12:50 pmSAN-MDE
12h 05m1 stop
American Airlines Logo
6:00 am - 9:58 pmMDE-SAN
17h 58m1 stop
$453American Airlines
Find Deal
Tue, Sep 9 - Wed, Sep 24
United Airlines Logo
8:00 am - 10:05 pmSAN-MDE
11h 05m1 stop
United Airlines Logo
10:45 am - 6:24 pmMDE-SAN
10h 39m1 stop
$457United Airlines
Find Deal
Mon, Nov 3 - Fri, Nov 14
United Airlines Logo
6:45 am - 10:05 pmSAN-MDE
12h 20m2 stops
United Airlines Logo
10:45 am - 12:13 amMDE-SAN
16h 28m2 stops
$461United Airlines
Find Deal
Wed, Nov 5 - Fri, Nov 14

Copa Airlines flights from San Diego to South America

Our best Copa Airlines deals on San Diego to South America flight tickets
Copa Airlines
Nov 12
SAN8:10 pmSan Diego
15h 05m
1 stop
MDE2:15 pmMedellín Jose Maria Cordova Intl
Nov 19
MDE10:46 amMedellín Jose Maria Cordova Intl
9h 17m
1 stop
SAN5:03 pmSan Diego
$407
Find similar
Copa Airlines
Sep 29
SAN9:08 pmSan Diego
14h 21m
1 stop
BOG1:29 pmBogotá El Dorado
Oct 10
BOG8:35 amBogotá El Dorado
11h 22m
1 stop
SAN5:57 pmSan Diego
$411
Find similar
Copa Airlines
Sep 24
SAN9:08 pmSan Diego
10h 02m
1 stop
MDE9:10 amMedellín Jose Maria Cordova Intl
Sep 28
MDE9:15 amMedellín Jose Maria Cordova Intl
10h 35m
1 stop
SAN5:50 pmSan Diego
$414
Find similar

LATAM Airlines flights from San Diego to South America

Our best LATAM Airlines deals on San Diego to South America flight tickets
LATAM Airlines
Nov 10
SAN11:00 amSan Diego
16h 25m
2 stops
LIM6:25 amLima J Chavez Intl
Nov 17
LIM12:15 amLima J Chavez Intl
18h 05m
2 stops
SAN3:20 pmSan Diego
$438
Find similar
LATAM Airlines
Oct 2
SAN6:15 amSan Diego
11h 00m
1 stop
BOG7:15 pmBogotá El Dorado
Oct 9
BOG9:00 amBogotá El Dorado
16h 14m
1 stop
SAN11:14 pmSan Diego
$446
Find similar
LATAM Airlines
Oct 2
SAN2:00 pmSan Diego
18h 55m
2 stops
BOG10:55 amBogotá El Dorado
Oct 9
BOG9:00 amBogotá El Dorado
11h 32m
1 stop
SAN6:32 pmSan Diego
$450
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from San Diego to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Wed 11/12

8:10 pm-2:15 pm

1 stop15h 05m

Medellín Jose Maria Cordova Intl

Wed 11/19

10:46 am-5:03 pm

1 stop9h 17m

$407

San DiegoCartagena

SAN - CTG

SANCTG

San Diego

Mon 9/29

7:47 pm-12:23 pm

2 stops14h 36m

Cartagena Rafael Nunez

Sat 10/4

1:29 pm-11:34 pm

2 stops12h 05m

$410

San DiegoLima

SAN - LIM

SANLIM

San Diego

Mon 11/10

11:00 am-6:25 am

2 stops16h 25m

Lima J Chavez Intl

Mon 11/17

12:15 am-3:20 pm

2 stops18h 05m

$438

San DiegoLima

SAN - LIM

SANLIM

San Diego

Sun 9/21

9:50 pm-8:15 pm

2 stops20h 25m

Lima J Chavez Intl

Mon 9/29

12:05 am-6:10 pm

2 stops20h 05m

$441

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

Fri 9/5

10:37 am-10:55 am

2 stops22h 18m

Bogotá El Dorado

Wed 9/17

1:35 am-7:27 pm

2 stops19h 52m

$444

San DiegoLima

SAN - LIM

SANLIM

San Diego

Wed 9/10

6:25 am-6:25 am

2 stops22h 00m

Lima J Chavez Intl

Wed 9/17

12:00 pm-10:59 pm

1 stop12h 59m

$446

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

Mon 9/22

10:45 pm-9:17 pm

1 stop20h 32m

Bogotá El Dorado

Wed 10/1

12:25 am-9:50 pm

1 stop23h 25m

$451

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Tue 9/9

10:45 pm-12:50 pm

1 stop12h 05m

Medellín Jose Maria Cordova Intl

Wed 9/24

6:00 am-9:58 pm

1 stop17h 58m

$453

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Mon 11/3

8:00 am-10:05 pm

1 stop11h 05m

Medellín Jose Maria Cordova Intl

Fri 11/14

10:45 am-6:24 pm

1 stop10h 39m

$457

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Wed 11/5

6:45 am-10:05 pm

2 stops12h 20m

Medellín Jose Maria Cordova Intl

Fri 11/14

10:45 am-12:13 am

2 stops16h 28m

$461

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from San Diego to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from San Diego to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $693. If you aren’t able to travel during the month of February, then book flights to South America from San Diego during August instead. Flights to South America in August, while not as cheap as those in February, still average around $699.

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from San Diego to South America is on a Monday when prices can be found for as low as $708. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from San Diego to South America for around $873.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest San Diego to South America flights are usually those with departure times in the evening. Our users have found flights to South America in the evening for as low as $736. If you have a flexible travel schedule, then try to avoid flying in the morning when prices are $808 on average. Flights to South America from San Diego in the morning are generally more expensive because this time of day is more convenient for travelers’ schedules.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $797 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from San Diego for as low as $569 on momondo.

Can stopping save me money on San Diego to South America flights?

You could potentially save up to 7% on your flight if you consider stops on a San Diego to South America flight.

Cheap San Diego to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to South America

Best Price Found

$107

Fastest flight time

8h 42m

Direct flights

None

Airports in South America

8 airports
The best one-way flight to South America from San Diego in the past 72 hours is $107. The best round-trip flight deal from San Diego to South America found on momondo in the last 72 hours is $407.
The fastest flight from San Diego to South America takes 8h 42m
There are no direct flights from San Diego to South America. Popular non-direct routes for this connection are San Diego Airport - Bogotá El Dorado Airport, San Diego Airport - Cartagena Rafael Nunez Airport and San Diego Airport - Medellín Jose Maria Cordova Intl Airport.
There are 8 airports near South America: Lima J Chavez Intl (LIM), Buenos Aires Ministro Pistarini (EZE), Rio de Janeiro–Galeão Intl (GIG), Cartagena Rafael Nunez (CTG), Bogotá El Dorado (BOG), Sao Paulo Guarulhos Intl (GRU), Santiago Arturo Merino Benitez (SCL), Medellín Jose Maria Cordova Intl (MDE)
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  • When did momondo last update prices for flights from San Diego Airport to South America?

    Prices for flights from San Diego Airport to South America were last updated today.

  • How many operators does momondo search for flights from San Diego Airport to South America?

  • How old do you have to be to fly from San Diego Airport to South America?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from San Diego to South America

Compare and see reviews for airlines that fly from San Diego to South America with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $337Free CancellationRating
7.5
1,507 reviews
Search Copa Airlines flights
Spirit AirlinesPriceFrom $406Free CancellationRating
6.3
8,045 reviews
Search Spirit Airlines flights
DeltaPriceFrom $449Free CancellationRating
8.0
7,980 reviews
Search Delta flights
United AirlinesPriceFrom $453Free CancellationRating
7.4
8,916 reviews
Search United Airlines flights
LATAM AirlinesPriceFrom $459Free CancellationRating
7.5
1,840 reviews
Search LATAM Airlines flights
American AirlinesPriceFrom $479Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to South America?

Finding the right flight to South America from San Diego is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South America quick and easy, saving you time and money.

Can I find flights from San Diego to South America with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to South America from San Diego with this policy.

How can momondo help me find flights from San Diego to South America?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Diego to South America.

I’m not ready to book a flight from San Diego to South America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South America from San Diego. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
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Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo
Flights to Limafrom $256
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Flights to Bogotáfrom $180
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Flights to Medellínfrom $171
Flights to Rio de Janeirofrom $451
Flights to Santiagofrom $352
Flights to Cartagenafrom $180
Flights to Quitofrom $309
Flights to Cuscofrom $349
Flights to Califrom $182
Flights to Guayaquilfrom $231