What is the cheapest airline that flies from San Diego to South America?

Copa Airlines, United Airlines, and LATAM Airlines are the most popular carriers operating from San Diego to South America

What airlines fly to South America?

Copa Airlines, United Airlines and American Airlines are the top three most popular airlines that fly to South America from San Diego according to our data. Copa Airlines is the first choice among our users, with 33% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 9 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from San Diego Airport to South America?

Prices for flights from San Diego Airport to South America were last updated today.

How many operators does momondo search for flights from San Diego Airport to South America?

There are 7 operators available for flights from San Diego Airport to South America as of September 2026.

How old do you have to be to fly from San Diego Airport to South America?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to South America.

What documentation or ID do you need to fly to South America?

The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$232 Cheap Flights from San Diego to South America in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Diego to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

10:30 pm - 2:15 pmSAN San Diego-MDE Medellín Jose Maria Cordova Intl

13h 45m1 stop Panama City Tocumen Intl

10:35 am - 6:30 pmMDE Medellín Jose Maria Cordova Intl-SAN San Diego

9h 55m1 stop Panama City Tocumen Intl

$518Copa Airlines

Sun, Oct 4 - Mon, Oct 19

10:30 pm - 9:40 amSAN San Diego-MDE Medellín Jose Maria Cordova Intl

9h 10m1 stop Panama City Tocumen Intl

10:35 am - 6:30 pmMDE Medellín Jose Maria Cordova Intl-SAN San Diego

9h 55m1 stop Panama City Tocumen Intl

$518Copa Airlines

Wed, Oct 14 - Mon, Oct 19

5:00 pm - 9:10 pmSAN San Diego-MDE Medellín Jose Maria Cordova Intl

26h 10m2 stops Los Angeles Houston George Bush Intcntl

9:45 am - 11:31 amMDE Medellín Jose Maria Cordova Intl-SAN San Diego

27h 46m2 stops Houston George Bush Intcntl Los Angeles

$552United Airlines

Sun, Oct 18 - Sun, Oct 25

4:45 pm - 9:15 pmSAN San Diego-MDE Medellín Jose Maria Cordova Intl

26h 30m2 stops Los Angeles Houston George Bush Intcntl

9:45 am - 11:57 amMDE Medellín Jose Maria Cordova Intl-SAN San Diego

28h 12m2 stops Houston George Bush Intcntl San Francisco

$552United Airlines

Sun, Oct 25 - Thu, Oct 29

10:39 pm - 9:26 pmSAN San Diego-MDE Medellín Jose Maria Cordova Intl

19h 47m1 stop Miami

3:09 pm - 11:45 pmMDE Medellín Jose Maria Cordova Intl-SAN San Diego

11h 36m1 stop Miami

$587American Airlines

Thu, Feb 4 - Wed, Feb 10

6:15 am - 9:10 pmSAN San Diego-MDE Medellín Jose Maria Cordova Intl

11h 55m2 stops Charlotte Douglas Miami

7:00 am - 7:28 pmMDE Medellín Jose Maria Cordova Intl-SAN San Diego

15h 28m2 stops Miami Chicago O'Hare Intl

$592American Airlines

Wed, Feb 17 - Tue, Feb 23

6:15 am - 9:50 pmSAN San Diego-LIM Lima J Chavez Intl

12h 35m1 stop Los Angeles

12:50 am - 10:30 amLIM Lima J Chavez Intl-SAN San Diego

12h 40m1 stop Los Angeles

$593LATAM Airlines

Sat, Feb 20 - Tue, Mar 2

6:15 am - 9:50 pmSAN San Diego-LIM Lima J Chavez Intl

12h 35m1 stop Los Angeles

12:00 pm - 10:56 pmLIM Lima J Chavez Intl-SAN San Diego

13h 56m1 stop Los Angeles

$593LATAM Airlines

Thu, Nov 26 - Mon, Dec 7

7:00 am - 9:10 amSAN San Diego-MDE Medellín Jose Maria Cordova Intl

24h 10m1 stop New York John F Kennedy Intl

8:00 pm - 2:35 pmMDE Medellín Jose Maria Cordova Intl-SAN San Diego

20h 35m1 stop New York John F Kennedy Intl

$617Multiple Airlines

Tue, Oct 13 - Tue, Oct 20

10:30 pm - 12:56 pmSAN San Diego-MDE Medellín Jose Maria Cordova Intl

12h 26m2 stops Panama City Tocumen Intl Cartagena Rafael Nunez

10:35 am - 6:30 pmMDE Medellín Jose Maria Cordova Intl-SAN San Diego

9h 55m1 stop Panama City Tocumen Intl

$618Multiple Airlines

Sun, Oct 4 - Mon, Oct 19

Cheap last minute flights

Enter your travel dates to find the best prices.

10:30 pm - 9:40 amSAN San Diego-MDE Medellín Jose Maria Cordova Intl

9h 10m1 stop Panama City Tocumen Intl

10:35 am - 6:29 pmMDE Medellín Jose Maria Cordova Intl-SAN San Diego

9h 54m1 stop Panama City Tocumen Intl

$601Copa Airlines

Mon, Sep 21 - Mon, Sep 28

10:30 pm - 10:55 amSAN San Diego-MDE Medellín Jose Maria Cordova Intl

10h 25m1 stop Panama City Tocumen Intl

6:20 pm - 6:29 pmMDE Medellín Jose Maria Cordova Intl-SAN San Diego

26h 09m1 stop Panama City Tocumen Intl

$619Copa Airlines

Mon, Sep 21 - Sat, Sep 26

10:46 pm - 8:15 pmSAN San Diego-MDE Medellín Jose Maria Cordova Intl

19h 29m2 stops Chicago O'Hare Intl Miami

6:00 am - 10:25 pmMDE Medellín Jose Maria Cordova Intl-SAN San Diego

18h 25m1 stop Miami

$631American Airlines

Mon, Sep 21 - Mon, Sep 28

8:00 am - 9:10 pmSAN San Diego-MDE Medellín Jose Maria Cordova Intl

11h 10m1 stop Houston George Bush Intcntl

9:45 am - 11:35 amMDE Medellín Jose Maria Cordova Intl-SAN San Diego

27h 50m2 stops Houston George Bush Intcntl Los Angeles

$667United Airlines

Thu, Sep 17 - Sun, Sep 20

5:00 pm - 9:10 pmSAN San Diego-MDE Medellín Jose Maria Cordova Intl

26h 10m2 stops Los Angeles Houston George Bush Intcntl

9:45 am - 11:35 amMDE Medellín Jose Maria Cordova Intl-SAN San Diego

27h 50m2 stops Houston George Bush Intcntl Los Angeles

$667United Airlines

Thu, Sep 17 - Sun, Sep 20

10:46 pm - 8:15 pmSAN San Diego-MDE Medellín Jose Maria Cordova Intl

19h 29m2 stops Chicago O'Hare Intl Miami

6:00 am - 11:25 pmMDE Medellín Jose Maria Cordova Intl-SAN San Diego

19h 25m2 stops Miami Chicago O'Hare Intl

$672American Airlines

Fri, Sep 18 - Wed, Sep 30

12:58 pm - 12:48 pmSAN San Diego-MDE Medellín Jose Maria Cordova Intl

21h 50m2 stops Charlotte Douglas Miami

6:00 am - 8:18 amMDE Medellín Jose Maria Cordova Intl-SAN San Diego

28h 18m2 stops Miami Dallas/Fort Worth

$674GOL

Fri, Sep 18 - Mon, Sep 21

7:00 am - 1:10 pmSAN San Diego-MDE Medellín Jose Maria Cordova Intl

28h 10m2 stops New York John F Kennedy Intl San Salvador El Salvador Intl

10:40 pm - 2:50 pmMDE Medellín Jose Maria Cordova Intl-SAN San Diego

18h 10m1 stop New York John F Kennedy Intl

$692Multiple Airlines

Mon, Sep 21 - Sat, Sep 26

8:00 am - 4:10 amSAN San Diego-LIM Lima J Chavez Intl

18h 10m2 stops Dallas/Fort Worth Miami

6:30 am - 11:19 pmLIM Lima J Chavez Intl-SAN San Diego

18h 49m2 stops Miami Chicago O'Hare Intl

$718GOL

Mon, Sep 21 - Tue, Oct 13

10:04 pm - 8:40 pmSAN San Diego-GRU Sao Paulo Guarulhos Intl

18h 36m1 stop Boston Logan Intl

8:30 pm - 8:28 pmGRU Sao Paulo Guarulhos Intl-SAN San Diego

27h 58m1 stop New York John F Kennedy Intl

$1,033Multiple Airlines

Sat, Sep 19 - Sun, Sep 27

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Air Canada flights from San Diego to South America

Our best Air Canada deals on San Diego to South America flight tickets

Air Canada

Nov 25

SAN5:15 pmSan Diego

34h 45m

2 stops

GRU9:00 amSao Paulo Guarulhos Intl

Dec 9

GRU9:45 pmSao Paulo Guarulhos Intl

23h 10m

2 stops

SAN3:55 pmSan Diego

$768

Air Canada

Mar 6

SAN12:55 pmSan Diego

39h 05m

2 stops

GRU9:00 amSao Paulo Guarulhos Intl

Mar 17

GRU9:45 pmSao Paulo Guarulhos Intl

42h 12m

2 stops

SAN11:57 amSan Diego

$838

Air Canada

Mar 2

SAN7:05 amSan Diego

20h 55m

2 stops

GRU9:00 amSao Paulo Guarulhos Intl

Mar 10

GRU9:45 pmSao Paulo Guarulhos Intl

43h 12m

2 stops

SAN11:57 amSan Diego

$842

United Airlines flights from San Diego to South America

Our best United Airlines deals on San Diego to South America flight tickets

United Airlines

Oct 18

SAN5:00 pmSan Diego

26h 10m

2 stops

MDE9:10 pmMedellín Jose Maria Cordova Intl

Oct 25

MDE9:45 amMedellín Jose Maria Cordova Intl

27h 46m

2 stops

SAN11:31 amSan Diego

$552

United Airlines

Oct 25

SAN4:45 pmSan Diego

26h 30m

2 stops

MDE9:15 pmMedellín Jose Maria Cordova Intl

Oct 29

MDE9:45 amMedellín Jose Maria Cordova Intl

29h 39m

1 stop

SAN1:24 pmSan Diego

$563

United Airlines

Oct 27

SAN8:05 amSan Diego

11h 10m

1 stop

MDE9:15 pmMedellín Jose Maria Cordova Intl

Nov 3

MDE10:40 amMedellín Jose Maria Cordova Intl

10h 13m

1 stop

SAN5:53 pmSan Diego

$567

momondo Fare Finder

Use the filters below to find and compare flights from San Diego to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San DiegoMedellín

SAN San Diego - MDE Medellín Jose Maria Cordova Intl

SANMDE

San Diego

Sun 10/4

10:30 pm-2:15 pm

1 stop13h 45m

Medellín Jose Maria Cordova Intl

Mon 10/19

10:35 am-6:30 pm

1 stop9h 55m

$518

Quickest round-trip

San DiegoMedellín

SAN San Diego - MDE Medellín Jose Maria Cordova Intl

SANMDE

San Diego

Wed 10/14

10:30 pm-9:40 am

1 stop9h 10m

Medellín Jose Maria Cordova Intl

Mon 10/19

10:35 am-6:30 pm

1 stop9h 55m

$518

San DiegoMedellín

SAN San Diego - MDE Medellín Jose Maria Cordova Intl

SANMDE

San Diego

Sun 10/18

5:00 pm-9:10 pm

2 stops26h 10m

Medellín Jose Maria Cordova Intl

Sun 10/25

9:45 am-11:31 am

2 stops27h 46m

$552

San DiegoMedellín

SAN San Diego - MDE Medellín Jose Maria Cordova Intl

SANMDE

San Diego

Sun 10/25

4:45 pm-9:15 pm

2 stops26h 30m

Medellín Jose Maria Cordova Intl

Thu 10/29

9:45 am-11:57 am

2 stops28h 12m

$552

San DiegoMedellín

SAN San Diego - MDE Medellín Jose Maria Cordova Intl

SANMDE

San Diego

Thu 2/4

10:39 pm-9:26 pm

1 stop19h 47m

Medellín Jose Maria Cordova Intl

Wed 2/10

3:09 pm-11:45 pm

1 stop11h 36m

$587

San DiegoMedellín

SAN San Diego - MDE Medellín Jose Maria Cordova Intl

SANMDE

San Diego

Wed 2/17

6:15 am-9:10 pm

2 stops11h 55m

Medellín Jose Maria Cordova Intl

Tue 2/23

7:00 am-7:28 pm

2 stops15h 28m

$592

San DiegoLima

SAN San Diego - LIM Lima J Chavez Intl

SANLIM

San Diego

Sat 2/20

6:15 am-9:50 pm

1 stop12h 35m

Lima J Chavez Intl

Tue 3/2

12:50 am-10:30 am

1 stop12h 40m

$593

San DiegoLima

SAN San Diego - LIM Lima J Chavez Intl

SANLIM

San Diego

Thu 11/26

6:15 am-9:50 pm

1 stop12h 35m

Lima J Chavez Intl

Mon 12/7

12:00 pm-10:56 pm

1 stop13h 56m

$593

San DiegoMedellín

SAN San Diego - MDE Medellín Jose Maria Cordova Intl

SANMDE

San Diego

Tue 10/13

7:00 am-9:10 am

1 stop24h 10m

Medellín Jose Maria Cordova Intl

Tue 10/20

8:00 pm-2:35 pm

1 stop20h 35m

$617

San DiegoMedellín

SAN San Diego - MDE Medellín Jose Maria Cordova Intl

SANMDE

San Diego

Sun 10/4

10:30 pm-12:56 pm

2 stops12h 26m

Medellín Jose Maria Cordova Intl

Mon 10/19

10:35 am-6:30 pm

1 stop9h 55m

$618

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from San Diego to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from San Diego to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $651. If you aren’t able to travel during the month of February, then book flights to South America from San Diego during April instead. Flights to South America in April, while not as cheap as those in February, still average around $672.

How far in advance should I book a flight from San Diego to South America?

You are more likely to see cheaper flights to South America from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $742 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from San Diego for as low as $579 on momondo.

Can stopping save me money on San Diego to South America flights?

You could potentially save up to 22% on your flight if you consider stops on a San Diego to South America flight.

Cheap San Diego to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to South America

Best Price Found	$232
Fastest flight time	8h 05m
Direct flights	None

The best one-way flight to South America from San Diego in the past 72 hours is $232. The best round-trip flight deal from San Diego to South America found on momondo in the last 72 hours is $518.

The fastest flight from San Diego to South America takes 8h 05m

There are no direct flights from San Diego to South America. There are no popular flight routes from San Diego to South America.

Search flight deals

Frequently asked questions about flying from San Diego to South America

When did momondo last update prices for flights from San Diego Airport to South America?
Prices for flights from San Diego Airport to South America were last updated today.
How many operators does momondo search for flights from San Diego Airport to South America?
There are 7 operators available for flights from San Diego Airport to South America as of September 2026.
How old do you have to be to fly from San Diego Airport to South America?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to South America.
What documentation or ID do you need to fly to South America?
The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from San Diego to South America

Compare and see reviews for airlines that fly from San Diego to South America with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $253	Free Cancellation	Rating 7.4 10,215 reviews	Search United Airlines flights
Copa Airlines	PriceFrom $311	Free Cancellation	Rating 7.6 1,543 reviews	Search Copa Airlines flights
American Airlines	PriceFrom $437	Free Cancellation	Rating 7.1 12,063 reviews	Search American Airlines flights
LATAM Airlines	PriceFrom $464	Free Cancellation	Rating 7.4 1,985 reviews	Search LATAM Airlines flights
Air Canada	PriceFrom $516	Free Cancellation	Rating 7.1 11,636 reviews	Search Air Canada flights
Delta	PriceFrom $525	Free Cancellation	Rating 7.8 8,572 reviews	Search Delta flights
GOL	PriceFrom $695	Free Cancellation	Rating 7.3 1,304 reviews	Search GOL flights

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to South America?

Finding the right flight to South America from San Diego is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South America quick and easy, saving you time and money.

Can I find flights from San Diego to South America with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to South America from San Diego with this policy.

How can momondo help me find flights from San Diego to South America?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Diego to South America.

I’m not ready to book a flight from San Diego to South America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South America from San Diego. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.