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Cheap flights from San Diego to South America from $151

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to South America departing on 9/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Diego to South America

Cheap round-trip flights

Copa Airlines Logo
8:10 pm - 2:45 pmSAN-MDE
15h 35m1 stop
Copa Airlines Logo
10:46 am - 5:03 pmMDE-SAN
9h 17m1 stop
$381Copa Airlines
Find Deal
Wed, Nov 12 - Wed, Nov 19
Copa Airlines Logo
9:07 pm - 8:18 amSAN-MDE
9h 11m1 stop
Copa Airlines Logo
6:20 pm - 6:03 pmMDE-SAN
25h 43m1 stop
$396Copa Airlines
Find Deal
Sun, Oct 26 - Sat, Nov 1
LATAM Airlines Logo
6:15 am - 7:30 pmSAN-BOG
10h 15m1 stop
LATAM Airlines Logo
8:35 am - 8:07 pmBOG-SAN
14h 32m1 stop
$435LATAM Airlines
Find Deal
Fri, Nov 7 - Wed, Nov 12
United Airlines Logo
10:20 am - 10:35 pmSAN-BOG
9h 15m1 stop
United Airlines Logo
1:30 am - 9:56 pmBOG-SAN
23h 26m1 stop
$444United Airlines
Find Deal
Sat, Nov 8 - Tue, Dec 23
LATAM Airlines Logo
10:30 pm - 1:40 pmSAN-BOG
13h 10m1 stop
LATAM Airlines Logo
10:45 am - 9:48 amBOG-SAN
25h 03m2 stops
$446LATAM Airlines
Find Deal
Sun, Sep 28 - Fri, Oct 10
United Airlines Logo
6:15 am - 7:20 pmSAN-BOG
11h 05m1 stop
United Airlines Logo
12:14 am - 8:02 pmBOG-SAN
21h 48m1 stop
$450United Airlines
Find Deal
Sun, Sep 28 - Thu, Oct 9
American Airlines Logo
6:30 am - 9:10 pmSAN-MDE
11h 40m2 stops
American Airlines Logo
7:00 am - 8:48 pmMDE-SAN
16h 48m2 stops
$457American Airlines
Find Deal
Wed, Nov 12 - Wed, Nov 19
American Airlines Logo
3:01 pm - 12:50 pmSAN-MDE
19h 49m2 stops
American Airlines Logo
6:00 am - 9:58 pmMDE-SAN
17h 58m1 stop
$458American Airlines
Find Deal
Wed, Oct 1 - Sat, Oct 4
Delta Logo
1:38 pm - 10:55 amSAN-BOG
19h 17m2 stops
Delta Logo
2:55 pm - 4:08 pmBOG-SAN
27h 13m1 stop
$470Delta
Find Deal
Sun, Sep 28 - Fri, Oct 10
Delta Logo
9:50 pm - 7:54 pmSAN-BOG
20h 04m2 stops
Delta Logo
1:35 am - 6:00 pmBOG-SAN
18h 25m2 stops
$471Delta
Find Deal
Mon, Sep 22 - Sun, Sep 28

LATAM Airlines flights from San Diego to South America

Our best LATAM Airlines deals on San Diego to South America flight tickets
LATAM Airlines
Nov 7
SAN6:15 amSan Diego
10h 15m
1 stop
BOG7:30 pmBogotá El Dorado
Nov 12
BOG8:35 amBogotá El Dorado
14h 32m
1 stop
SAN8:07 pmSan Diego
$435
Find similar
LATAM Airlines
Sep 28
SAN10:30 pmSan Diego
13h 10m
1 stop
BOG1:40 pmBogotá El Dorado
Oct 10
BOG10:45 amBogotá El Dorado
25h 03m
2 stops
SAN9:48 amSan Diego
$446
Find similar
LATAM Airlines
Sep 22
SAN10:30 pmSan Diego
18h 45m
1 stop
BOG7:15 pmBogotá El Dorado
Sep 29
BOG10:15 amBogotá El Dorado
12h 14m
1 stop
SAN8:29 pmSan Diego
$448
Find similar

Copa Airlines flights from San Diego to South America

Our best Copa Airlines deals on San Diego to South America flight tickets
Copa Airlines
Nov 12
SAN8:10 pmSan Diego
15h 35m
1 stop
MDE2:45 pmMedellín Jose Maria Cordova Intl
Nov 19
MDE10:46 amMedellín Jose Maria Cordova Intl
9h 17m
1 stop
SAN5:03 pmSan Diego
$381
Find similar
Copa Airlines
Oct 26
SAN9:07 pmSan Diego
9h 11m
1 stop
MDE8:18 amMedellín Jose Maria Cordova Intl
Nov 1
MDE6:20 pmMedellín Jose Maria Cordova Intl
25h 43m
1 stop
SAN6:03 pmSan Diego
$396
Find similar
Copa Airlines
Sep 24
SAN9:08 pmSan Diego
9h 09m
1 stop
MDE8:17 amMedellín Jose Maria Cordova Intl
Sep 28
MDE10:46 amMedellín Jose Maria Cordova Intl
9h 04m
1 stop
SAN5:50 pmSan Diego
$401
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from San Diego to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Wed 11/12

8:10 pm-2:45 pm

1 stop15h 35m

Medellín Jose Maria Cordova Intl

Wed 11/19

10:46 am-5:03 pm

1 stop9h 17m

$381

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Sun 10/26

9:07 pm-8:18 am

1 stop9h 11m

Medellín Jose Maria Cordova Intl

Sat 11/1

6:20 pm-6:03 pm

1 stop25h 43m

$396

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

Fri 11/7

6:15 am-7:30 pm

1 stop10h 15m

Bogotá El Dorado

Wed 11/12

8:35 am-8:07 pm

1 stop14h 32m

$435

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

Sat 11/8

10:20 am-10:35 pm

1 stop9h 15m

Bogotá El Dorado

Tue 12/23

1:30 am-9:56 pm

1 stop23h 26m

$444

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

Sun 9/28

10:30 pm-1:40 pm

1 stop13h 10m

Bogotá El Dorado

Fri 10/10

10:45 am-9:48 am

2 stops25h 03m

$446

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

Sun 9/28

6:15 am-7:20 pm

1 stop11h 05m

Bogotá El Dorado

Thu 10/9

12:14 am-8:02 pm

1 stop21h 48m

$450

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Wed 11/12

6:30 am-9:10 pm

2 stops11h 40m

Medellín Jose Maria Cordova Intl

Wed 11/19

7:00 am-8:48 pm

2 stops16h 48m

$457

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Wed 10/1

3:01 pm-12:50 pm

2 stops19h 49m

Medellín Jose Maria Cordova Intl

Sat 10/4

6:00 am-9:58 pm

1 stop17h 58m

$458

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

Sun 9/28

1:38 pm-10:55 am

2 stops19h 17m

Bogotá El Dorado

Fri 10/10

2:55 pm-4:08 pm

1 stop27h 13m

$470

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

Mon 9/22

9:50 pm-7:54 pm

2 stops20h 04m

Bogotá El Dorado

Sun 9/28

1:35 am-6:00 pm

2 stops18h 25m

$471

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from San Diego to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, August is the cheapest month to fly from San Diego to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $684. If you aren’t able to travel during the month of August, then book flights to South America from San Diego during February instead. Flights to South America in February, while not as cheap as those in August, still average around $693.

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from San Diego to South America is on a Monday when prices can be found for as low as $708. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from San Diego to South America for around $873.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest San Diego to South America flights are usually those with departure times in the evening. Our users have found flights to South America in the evening for as low as $736. If you have a flexible travel schedule, then try to avoid flying in the morning when prices are $808 on average. Flights to South America from San Diego in the morning are generally more expensive because this time of day is more convenient for travelers’ schedules.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $795 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from San Diego for as low as $569 on momondo.

Can stopping save me money on San Diego to South America flights?

You could potentially save up to 24% on your flight if you consider stops on a San Diego to South America flight.

Cheap San Diego to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to South America

Direct flights

None
There are no direct flights from San Diego to South America. There are no popular flight routes from San Diego to South America.
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  • When did momondo last update prices for flights from San Diego Airport to South America?

    Prices for flights from San Diego Airport to South America were last updated today.

  • How many operators does momondo search for flights from San Diego Airport to South America?

  • How old do you have to be to fly from San Diego Airport to South America?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from San Diego to South America

Compare and see reviews for airlines that fly from San Diego to South America with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $314Free CancellationRating
6.3
8,023 reviews
Search Spirit Airlines flights
Copa AirlinesPriceFrom $337Free CancellationRating
7.6
1,531 reviews
Search Copa Airlines flights
DeltaPriceFrom $430Free CancellationRating
7.9
7,960 reviews
Search Delta flights
LATAM AirlinesPriceFrom $452Free CancellationRating
7.5
1,847 reviews
Search LATAM Airlines flights
United AirlinesPriceFrom $479Free CancellationRating
7.4
8,937 reviews
Search United Airlines flights
American AirlinesPriceFrom $479Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to South America?

Finding the right flight to South America from San Diego is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South America quick and easy, saving you time and money.

Can I find flights from San Diego to South America with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to South America from San Diego with this policy.

How can momondo help me find flights from San Diego to South America?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Diego to South America.

I’m not ready to book a flight from San Diego to South America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South America from San Diego. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo
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