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Cheap flights from San Antonio to Des Moines from $121

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Antonio to Des Moines departing on 12/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Antonio to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:56 pm - 7:03 pmSAT-DSM
23h 07m1 stop
Multiple Airlines Logo
8:30 am - 11:49 amDSM-SAT
27h 19m1 stop
$219Multiple Airlines
Find Deal
Sun, Dec 14 - Thu, Jan 8
Multiple Airlines Logo
7:56 pm - 7:03 pmSAT-DSM
23h 07m1 stop
Multiple Airlines Logo
8:30 am - 11:49 amDSM-SAT
27h 19m1 stop
$232Multiple Airlines
Find Deal
Sun, Dec 14 - Thu, Jan 8
Multiple Airlines Logo
7:56 pm - 7:03 pmSAT-DSM
23h 07m1 stop
Multiple Airlines Logo
10:53 am - 11:50 amDSM-SAT
24h 57m1 stop
$241Multiple Airlines
Find Deal
Sun, Dec 14 - Tue, Jan 6
Frontier Logo
7:56 pm - 7:03 pmSAT-DSM
23h 07m1 stop
Frontier Logo
8:17 pm - 3:00 pmDSM-SAT
18h 43m1 stop
$250Frontier
Find Deal
Sun, Dec 14 - Fri, Jan 9
Multiple Airlines Logo
7:56 pm - 7:03 pmSAT-DSM
23h 07m1 stop
Multiple Airlines Logo
8:30 am - 9:18 amDSM-SAT
24h 48m2 stops
$252Multiple Airlines
Find Deal
Sun, Dec 14 - Thu, Jan 8
Multiple Airlines Logo
7:56 pm - 7:03 pmSAT-DSM
23h 07m1 stop
Multiple Airlines Logo
10:00 am - 4:08 pmDSM-SAT
30h 08m1 stop
$257Multiple Airlines
Find Deal
Sun, Dec 14 - Sat, Jan 10
Multiple Airlines Logo
2:39 pm - 10:36 pmSAT-DSM
7h 57m1 stop
Multiple Airlines Logo
8:30 am - 11:49 amDSM-SAT
27h 19m1 stop
$262Multiple Airlines
Find Deal
Thu, Dec 18 - Thu, Jan 8
Multiple Airlines Logo
6:10 pm - 3:31 pmSAT-DSM
21h 21m1 stop
Multiple Airlines Logo
8:30 am - 11:49 amDSM-SAT
27h 19m1 stop
$264Multiple Airlines
Find Deal
Wed, Dec 17 - Thu, Jan 8
Multiple Airlines Logo
7:56 pm - 7:03 pmSAT-DSM
23h 07m1 stop
Multiple Airlines Logo
8:30 am - 9:18 amDSM-SAT
24h 48m2 stops
$265Multiple Airlines
Find Deal
Sun, Dec 14 - Thu, Jan 8
Multiple Airlines Logo
7:56 pm - 7:03 pmSAT-DSM
23h 07m1 stop
Multiple Airlines Logo
11:09 am - 11:52 pmDSM-SAT
12h 43m2 stops
$282Multiple Airlines
Find Deal
Sun, Dec 14 - Mon, Jan 12

Frontier flights from San Antonio to Des Moines

Our best Frontier deals on San Antonio to Des Moines flight tickets
Frontier
Dec 14
SAT7:56 pmSan Antonio
23h 07m
1 stop
DSM7:03 pmDes Moines
Jan 9
DSM8:17 pmDes Moines
18h 43m
1 stop
SAT3:00 pmSan Antonio
$250
Find similar
Frontier
Dec 11
SAT3:06 pmSan Antonio
27h 57m
1 stop
DSM7:03 pmDes Moines
Dec 19
DSM8:29 pmDes Moines
14h 52m
1 stop
SAT11:21 amSan Antonio
$311
Find similar

Delta flights from San Antonio to Des Moines

Our best Delta deals on San Antonio to Des Moines flight tickets
Delta
Dec 16
SAT5:10 amSan Antonio
5h 28m
1 stop
DSM10:38 amDes Moines
Jan 10
DSM1:03 pmDes Moines
7h 40m
1 stop
SAT8:43 pmSan Antonio
$303
Find similar
Delta
Dec 15
SAT6:25 amSan Antonio
7h 54m
1 stop
DSM2:19 pmDes Moines
Jan 6
DSM6:54 amDes Moines
5h 19m
1 stop
SAT12:13 pmSan Antonio
$315
Find similar
Delta
Dec 14
SAT5:10 amSan Antonio
5h 28m
1 stop
DSM10:38 amDes Moines
Jan 7
DSM4:21 pmDes Moines
5h 13m
1 stop
SAT9:34 pmSan Antonio
$348
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Antonio to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 24, 2025.
Use the filters below to find and compare flights from San Antonio to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Sun 12/14

7:56 pm-7:03 pm

1 stop23h 07m

Des Moines

Thu 1/8

8:30 am-11:49 am

1 stop27h 19m

$219

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Sun 12/14

7:56 pm-7:03 pm

1 stop23h 07m

Des Moines

Thu 1/8

8:30 am-11:49 am

1 stop27h 19m

$232

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Sun 12/14

7:56 pm-7:03 pm

1 stop23h 07m

Des Moines

Tue 1/6

10:53 am-11:50 am

1 stop24h 57m

$241

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Sun 12/14

7:56 pm-7:03 pm

1 stop23h 07m

Des Moines

Fri 1/9

8:17 pm-3:00 pm

1 stop18h 43m

$250

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Sun 12/14

7:56 pm-7:03 pm

1 stop23h 07m

Des Moines

Thu 1/8

8:30 am-9:18 am

2 stops24h 48m

$252

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Sun 12/14

7:56 pm-7:03 pm

1 stop23h 07m

Des Moines

Sat 1/10

10:00 am-4:08 pm

1 stop30h 08m

$257

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Thu 12/18

2:39 pm-10:36 pm

1 stop7h 57m

Des Moines

Thu 1/8

8:30 am-11:49 am

1 stop27h 19m

$262

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Wed 12/17

6:10 pm-3:31 pm

1 stop21h 21m

Des Moines

Thu 1/8

8:30 am-11:49 am

1 stop27h 19m

$264

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Sun 12/14

7:56 pm-7:03 pm

1 stop23h 07m

Des Moines

Thu 1/8

8:30 am-9:18 am

2 stops24h 48m

$265

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Sun 12/14

7:56 pm-7:03 pm

1 stop23h 07m

Des Moines

Mon 1/12

11:09 am-11:52 pm

2 stops12h 43m

$282

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Antonio to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in June, then September is your next best option. Flight prices from San Antonio to Des Moines during September average around $340.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from San Antonio to Des Moines is on a Tuesday. Travelers who choose to depart for Des Moines on a Tuesday will often find tickets for as low as $313. Flights from San Antonio to Des Moines on a Sunday will generally be more expensive and average around $569. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the evening. momondo users have found flights departing from San Antonio to Des Moines in the evening for as low as $350. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the afternoon because they tend to be around $580. Of course, these prices can vary depending on the time of year and what airport you fly to.

How have San Antonio to Des Moines flight prices changed over time?

As of November 2025, prices for San Antonio to Des Moines flights are approximately 32% more expensive when compared to flights at the same time last year.

When to book flights from San Antonio to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Antonio to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Antonio to Des Moines (SAT to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Antonio to Des Moines

Direct flights

None
There are no direct flights from San Antonio to Des Moines. There are no popular flight routes from San Antonio to Des Moines.
Search flight deals

  • How far is San Antonio to Des Moines by plane?

    The distance between San Antonio and Des Moines is about 882.7 mi. By plane, this route typically takes 4h 30m.

  • When did momondo last update prices for flights from San Antonio Airport to Des Moines Airport?

    Prices for flights from San Antonio Airport to Des Moines Airport are updated daily.

  • How many operators does momondo search for flights from San Antonio Airport to Des Moines Airport?

  • How old do you have to be to fly from San Antonio Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Antonio Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Antonio to Des Moines?

Best airlines flying from San Antonio to Des Moines

Compare and see reviews for airlines that fly from San Antonio to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $212Free CancellationRating
7.9
7,997 reviews
Search Delta flights
American AirlinesPriceFrom $278Free CancellationRating
7.2
11,046 reviews
Search American Airlines flights
United AirlinesPriceFrom $384Free CancellationRating
7.4
9,037 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Newton
Pella
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Antonio to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Antonio to Des Moines for you.

Can I find flights from San Antonio to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from San Antonio with this policy.

How can momondo help me find flights from San Antonio to Des Moines?

Once all potential San Antonio to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Antonio to Des Moines right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Antonio to Des Moines flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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