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Cheap flights from San Antonio to Des Moines from $214

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Antonio to Des Moines departing on 9/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Antonio to Des Moines

Cheap round-trip flights

Frontier Logo
3:59 pm - 1:52 pmSAT-DSM
21h 53m1 stop
Frontier Logo
2:37 pm - 7:41 pmDSM-SAT
5h 04m1 stop
$272Frontier
Find Deal
Wed, Oct 8 - Sun, Oct 12
Logo
6:00 am - 2:27 pmSAT-DSM
8h 27m1 stop
Logo
3:43 pm - 4:47 amDSM-SAT
13h 04m1 stop
$278
Find Deal
Wed, Oct 8 - Sun, Oct 12
American Airlines Logo
6:29 pm - 11:28 pmSAT-DSM
4h 59m1 stop
American Airlines Logo
5:10 am - 9:30 amDSM-SAT
4h 20m1 stop
$291American Airlines
Find Deal
Thu, Sep 18 - Mon, Sep 22
Delta Logo
6:41 am - 1:28 pmSAT-DSM
6h 47m1 stop
Delta Logo
6:39 pm - 12:20 amDSM-SAT
5h 41m1 stop
$322Delta
Find Deal
Wed, Oct 8 - Sun, Oct 12
Southwest Logo
3:50 pm - 9:50 pmSAT-DSM
6h 00m1 stop
Southwest Logo
6:10 pm - 1:00 amDSM-SAT
6h 50m2 stops
$327Southwest
Find Deal
Wed, Oct 8 - Sun, Oct 12
American Airlines Logo
4:48 pm - 11:06 pmSAT-DSM
6h 18m1 stop
American Airlines Logo
4:09 pm - 9:47 pmDSM-SAT
5h 38m1 stop
$329American Airlines
Find Deal
Fri, Sep 19 - Mon, Sep 22
Delta Logo
5:25 am - 10:38 amSAT-DSM
5h 13m1 stop
Delta Logo
5:54 pm - 11:25 pmDSM-SAT
5h 31m1 stop
$332Delta
Find Deal
Wed, Sep 10 - Fri, Sep 12
United Airlines Logo
5:30 am - 2:20 pmSAT-DSM
8h 50m2 stops
United Airlines Logo
11:34 am - 4:51 pmDSM-SAT
5h 17m1 stop
$344United Airlines
Find Deal
Wed, Sep 10 - Fri, Sep 12
Southwest Logo
2:20 pm - 9:50 pmSAT-DSM
7h 30m2 stops
Southwest Logo
6:10 pm - 1:00 amDSM-SAT
6h 50m2 stops
$367Southwest
Find Deal
Wed, Oct 8 - Sun, Oct 12
United Airlines Logo
6:30 am - 2:10 pmSAT-DSM
7h 40m1 stop
United Airlines Logo
1:10 pm - 10:48 pmDSM-SAT
9h 38m2 stops
$400United Airlines
Find Deal
Thu, Sep 18 - Mon, Sep 22

Frontier flights from San Antonio to Des Moines

Our best Frontier deals on San Antonio to Des Moines flight tickets
Frontier
Oct 8
SAT3:59 pmSan Antonio
21h 53m
1 stop
DSM1:52 pmDes Moines
Oct 12
DSM2:37 pmDes Moines
5h 04m
1 stop
SAT7:41 pmSan Antonio
$272
Find similar
Frontier
Oct 8
SAT3:59 pmSan Antonio
21h 53m
1 stop
DSM1:52 pmDes Moines
Oct 12
DSM2:37 pmDes Moines
5h 04m
1 stop
SAT7:41 pmSan Antonio
$280
Find similar

Southwest flights from San Antonio to Des Moines

Our best Southwest deals on San Antonio to Des Moines flight tickets
Southwest
Oct 8
SAT3:50 pmSan Antonio
6h 00m
1 stop
DSM9:50 pmDes Moines
Oct 12
DSM6:10 pmDes Moines
6h 50m
2 stops
SAT1:00 amSan Antonio
$327
Find similar
Southwest
Oct 8
SAT2:20 pmSan Antonio
7h 30m
2 stops
DSM9:50 pmDes Moines
Oct 12
DSM6:10 pmDes Moines
6h 50m
2 stops
SAT1:00 amSan Antonio
$367
Find similar
Southwest
Sep 19
SAT2:50 pmSan Antonio
8h 00m
2 stops
DSM10:50 pmDes Moines
Sep 22
DSM6:00 amDes Moines
5h 55m
1 stop
SAT11:55 amSan Antonio
$375
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Antonio to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from San Antonio to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Wed 10/8

3:59 pm-1:52 pm

1 stop21h 53m

Des Moines

Sun 10/12

2:37 pm-7:41 pm

1 stop5h 04m

$272

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Wed 10/8

6:00 am-2:27 pm

1 stop8h 27m

Des Moines

Sun 10/12

3:43 pm-4:47 am

1 stop13h 04m

$278

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Thu 9/18

6:29 pm-11:28 pm

1 stop4h 59m

Des Moines

Mon 9/22

5:10 am-9:30 am

1 stop4h 20m

$291

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Wed 10/8

6:41 am-1:28 pm

1 stop6h 47m

Des Moines

Sun 10/12

6:39 pm-12:20 am

1 stop5h 41m

$322

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Wed 10/8

3:50 pm-9:50 pm

1 stop6h 00m

Des Moines

Sun 10/12

6:10 pm-1:00 am

2 stops6h 50m

$327

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Fri 9/19

4:48 pm-11:06 pm

1 stop6h 18m

Des Moines

Mon 9/22

4:09 pm-9:47 pm

1 stop5h 38m

$329

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Wed 9/10

5:25 am-10:38 am

1 stop5h 13m

Des Moines

Fri 9/12

5:54 pm-11:25 pm

1 stop5h 31m

$332

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Wed 9/10

5:30 am-2:20 pm

2 stops8h 50m

Des Moines

Fri 9/12

11:34 am-4:51 pm

1 stop5h 17m

$344

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Wed 10/8

2:20 pm-9:50 pm

2 stops7h 30m

Des Moines

Sun 10/12

6:10 pm-1:00 am

2 stops6h 50m

$367

San AntonioDes Moines

SAT - DSM

SATDSM

San Antonio

Thu 9/18

6:30 am-2:10 pm

1 stop7h 40m

Des Moines

Mon 9/22

1:10 pm-10:48 pm

2 stops9h 38m

$400

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Antonio to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in June, then April is your next best option. Flight prices from San Antonio to Des Moines during April average around $345.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from San Antonio to Des Moines is on a Tuesday. Travelers who choose to depart for Des Moines on a Tuesday will often find tickets for as low as $313. Flights from San Antonio to Des Moines on a Sunday will generally be more expensive and average around $569. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the evening. momondo users have found flights departing from San Antonio to Des Moines in the evening for as low as $350. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the afternoon because they tend to be around $580. Of course, these prices can vary depending on the time of year and what airport you fly to.

How have San Antonio to Des Moines flight prices changed over time?

As of August 2025, prices for San Antonio to Des Moines flights are approximately 31% cheaper when compared to flights at the same time last year.

When to book flights from San Antonio to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Antonio to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Antonio to Des Moines (SAT to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Antonio to Des Moines

Best Price Found

$214

Fastest flight time

4h 59m

Direct flights

None

Airports in Des Moines

1 airport
The best one-way flight to Des Moines from San Antonio in the past 72 hours is $214. The best round-trip flight deal from San Antonio to Des Moines found on momondo in the last 72 hours is $272.
The fastest flight from San Antonio to Des Moines takes 4h 59m
There are no direct flights from San Antonio to Des Moines. Popular non-direct route for this connection is San Antonio Airport - Des Moines Airport.
There is 1 airport near Des Moines: Des Moines (DSM)
Search flight deals

  • How far is San Antonio to Des Moines by plane?

    The distance between San Antonio and Des Moines is about 882.7 mi. By plane, this route typically takes 4h 59m.

  • When did momondo last update prices for flights from San Antonio Airport to Des Moines Airport?

    Prices for flights from San Antonio Airport to Des Moines Airport are updated daily.

  • How many operators does momondo search for flights from San Antonio Airport to Des Moines Airport?

  • How old do you have to be to fly from San Antonio Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Antonio Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Antonio to Des Moines?

Best airlines flying from San Antonio to Des Moines

Compare and see reviews for airlines that fly from San Antonio to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $212Free CancellationRating
8.0
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $291Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $384Free CancellationRating
7.4
8,925 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Newton
Pella
Osceola
Johnston
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Antonio to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Antonio to Des Moines for you.

Can I find flights from San Antonio to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from San Antonio with this policy.

How can momondo help me find flights from San Antonio to Des Moines?

Once all potential San Antonio to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Antonio to Des Moines right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Antonio to Des Moines flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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