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Cheap flights from Rochester to Knoxville from $271

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Rochester to Knoxville departing on 4/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Rochester to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:15 am - 10:21 am
ROC
-
TYS
4h 06m
1 stop
Delta Logo
11:02 am - 3:22 pm
TYS
-
ROC
4h 20m
1 stop
$271Delta
Sat, Apr 25 - Sat, May 2
Multiple Airlines Logo
9:25 am - 12:00 pm
ROC
-
TYS
26h 35m
2 stops
Multiple Airlines Logo
4:25 pm - 9:33 am
TYS
-
ROC
17h 08m
1 stop
$286Multiple Airlines
Thu, Mar 5 - Wed, Mar 11
American Airlines Logo
5:25 pm - 9:54 pm
ROC
-
TYS
4h 29m
1 stop
American Airlines Logo
6:05 am - 11:59 am
TYS
-
ROC
5h 54m
1 stop
$289American Airlines
Sat, Mar 21 - Sat, Mar 28
Allegiant Air Logo
10:13 am - 8:57 pm
ROC
-
TYS
10h 44m
1 stop
Allegiant Air Logo
4:25 pm - 9:33 am
TYS
-
ROC
17h 08m
1 stop
$301Allegiant Air
Thu, Mar 5 - Wed, Mar 11
United Airlines Logo
10:32 am - 10:29 pm
ROC
-
TYS
11h 57m
2 stops
United Airlines Logo
7:00 am - 1:29 pm
TYS
-
ROC
6h 29m
1 stop
$309United Airlines
Mon, Apr 13 - Thu, Apr 16
Multiple Airlines Logo
9:25 am - 12:00 pm
ROC
-
TYS
26h 35m
2 stops
Multiple Airlines Logo
4:25 pm - 9:33 am
TYS
-
ROC
17h 08m
1 stop
$312Multiple Airlines
Thu, Mar 5 - Wed, Mar 11
Southwest Logo
8:05 am - 6:30 pm
ROC
-
TYS
10h 25m
2 stops
Southwest Logo
7:45 am - 11:40 am
TYS
-
ROC
3h 55m
1 stop
$313Southwest
Sat, Apr 25 - Sat, May 2
Delta Logo
12:50 pm - 8:20 pm
ROC
-
TYS
7h 30m
1 stop
Delta Logo
5:24 pm - 10:59 pm
TYS
-
ROC
5h 35m
1 stop
$314Delta
Thu, Mar 5 - Tue, Mar 10
Southwest Logo
8:05 am - 6:30 pm
ROC
-
TYS
10h 25m
2 stops
Southwest Logo
7:45 am - 6:05 pm
TYS
-
ROC
10h 20m
2 stops
$318Southwest
Sat, Apr 25 - Sat, May 2
American Airlines Logo
3:47 pm - 8:57 pm
ROC
-
TYS
5h 10m
1 stop
American Airlines Logo
6:05 am - 11:48 am
TYS
-
ROC
5h 43m
1 stop
$337American Airlines
Tue, Mar 10 - Fri, Mar 13

American Airlines flights from Rochester to Knoxville

Our best American Airlines deals on Rochester to Knoxville flight tickets
American Airlines
Apr 1
ROC5:08 amGreater Rochester Intl
6h 03m
1 stop
TYS11:11 amKnoxville McGhee Tyson
Apr 8
TYS12:01 pmKnoxville McGhee Tyson
5h 10m
1 stop
ROC5:11 pmGreater Rochester Intl
$271
American Airlines
Mar 21
ROC5:25 pmGreater Rochester Intl
4h 29m
1 stop
TYS9:54 pmKnoxville McGhee Tyson
Mar 28
TYS6:05 amKnoxville McGhee Tyson
5h 54m
1 stop
ROC11:59 amGreater Rochester Intl
$289
American Airlines
Mar 10
ROC3:47 pmGreater Rochester Intl
5h 10m
1 stop
TYS8:57 pmKnoxville McGhee Tyson
Mar 13
TYS6:05 amKnoxville McGhee Tyson
5h 43m
1 stop
ROC11:48 amGreater Rochester Intl
$337

United Airlines flights from Rochester to Knoxville

Our best United Airlines deals on Rochester to Knoxville flight tickets
United Airlines
Apr 1
ROC10:32 amGreater Rochester Intl
12h 31m
2 stops
TYS11:03 pmKnoxville McGhee Tyson
Apr 8
TYS7:20 pmKnoxville McGhee Tyson
4h 22m
1 stop
ROC11:42 pmGreater Rochester Intl
$298
United Airlines
Apr 13
ROC10:32 amGreater Rochester Intl
11h 57m
2 stops
TYS10:29 pmKnoxville McGhee Tyson
Apr 16
TYS7:00 amKnoxville McGhee Tyson
6h 29m
1 stop
ROC1:29 pmGreater Rochester Intl
$309
United Airlines
Mar 30
ROC6:00 amGreater Rochester Intl
4h 50m
1 stop
TYS10:50 amKnoxville McGhee Tyson
Apr 2
TYS7:00 amKnoxville McGhee Tyson
6h 29m
1 stop
ROC1:29 pmGreater Rochester Intl
$354

momondo Fare Finder

 
Customize your flight search to find flights from Rochester to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from Rochester to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Sat 4/25

6:15 am-10:21 am

1 stop4h 06m

Knoxville McGhee Tyson

Sat 5/2

11:02 am-3:22 pm

1 stop4h 20m

$271

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Thu 3/5

9:25 am-12:00 pm

2 stops26h 35m

Knoxville McGhee Tyson

Wed 3/11

4:25 pm-9:33 am

1 stop17h 08m

$286

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Sat 3/21

5:25 pm-9:54 pm

1 stop4h 29m

Knoxville McGhee Tyson

Sat 3/28

6:05 am-11:59 am

1 stop5h 54m

$289

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Thu 3/5

10:13 am-8:57 pm

1 stop10h 44m

Knoxville McGhee Tyson

Wed 3/11

4:25 pm-9:33 am

1 stop17h 08m

$301

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Mon 4/13

10:32 am-10:29 pm

2 stops11h 57m

Knoxville McGhee Tyson

Thu 4/16

7:00 am-1:29 pm

1 stop6h 29m

$309

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Thu 3/5

9:25 am-12:00 pm

2 stops26h 35m

Knoxville McGhee Tyson

Wed 3/11

4:25 pm-9:33 am

1 stop17h 08m

$312

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Sat 4/25

8:05 am-6:30 pm

2 stops10h 25m

Knoxville McGhee Tyson

Sat 5/2

7:45 am-11:40 am

1 stop3h 55m

$313

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Thu 3/5

12:50 pm-8:20 pm

1 stop7h 30m

Knoxville McGhee Tyson

Tue 3/10

5:24 pm-10:59 pm

1 stop5h 35m

$314

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Sat 4/25

8:05 am-6:30 pm

2 stops10h 25m

Knoxville McGhee Tyson

Sat 5/2

7:45 am-6:05 pm

2 stops10h 20m

$318

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Tue 3/10

3:47 pm-8:57 pm

1 stop5h 10m

Knoxville McGhee Tyson

Fri 3/13

6:05 am-11:48 am

1 stop5h 43m

$337

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Knoxville from

How to get the cheapest flight ticket from Rochester to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from Rochester, with most prices found around $293. If you aren’t able to travel during the month of September, then book flights to Knoxville from Rochester during February instead. Flights to Knoxville in February, while not as cheap as those in September, still average around $313.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Rochester when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $363 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Rochester for as low as $249 on momondo.

When to book flights from Rochester to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Rochester to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Rochester to Knoxville (ROC to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Rochester to Knoxville

Fastest flight time

4h 06m

Direct flights

None
The fastest flight from Rochester to Knoxville takes 4h 06m
There are no direct flights from Rochester to Knoxville. There are no popular flight routes from Rochester to Knoxville.
Search flight deals

  • How far is Greater Rochester Intl to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 599.1 mi away from Greater Rochester Intl. 4h 06m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Greater Rochester Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Greater Rochester Intl Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Greater Rochester Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Greater Rochester Intl Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greater Rochester Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Rochester to Knoxville?

Best airlines flying from Rochester to Knoxville

Compare and see reviews for airlines that fly from Rochester to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $168Free CancellationRating
7.9
8,144 reviews
Search Delta flights
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,236 reviews
Search United Airlines flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,222 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Rochester to Knoxville?

It is quick and easy to find Rochester to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Rochester to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Rochester to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Rochester to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Rochester. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Rochester to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Rochester to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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