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Cheap flights from Rochester to Knoxville from $127

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Rochester to Knoxville departing on 9/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Rochester to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:09 am - 10:45 am
ROC
-
TYS
5h 36m
1 stop
American Airlines Logo
5:15 am - 10:07 am
TYS
-
ROC
4h 52m
1 stop
$279American Airlines
Wed, Aug 12 - Tue, Aug 18
United Airlines Logo
10:19 am - 8:53 pm
ROC
-
TYS
10h 34m
2 stops
United Airlines Logo
9:45 am - 2:14 pm
TYS
-
ROC
4h 29m
1 stop
$284United Airlines
Wed, Aug 12 - Tue, Aug 18
United Airlines Logo
5:52 pm - 12:23 am
ROC
-
TYS
6h 31m
1 stop
United Airlines Logo
7:20 pm - 11:44 pm
TYS
-
ROC
4h 24m
1 stop
$285United Airlines
Tue, Sep 8 - Fri, Sep 11
United Airlines Logo
4:10 pm - 11:59 pm
ROC
-
TYS
7h 49m
2 stops
United Airlines Logo
7:00 am - 2:13 pm
TYS
-
ROC
7h 13m
2 stops
$290United Airlines
Wed, Aug 26 - Mon, Aug 31
Delta Logo
6:15 pm - 10:39 pm
ROC
-
TYS
4h 24m
1 stop
Delta Logo
6:12 pm - 11:50 pm
TYS
-
ROC
5h 38m
1 stop
$291Delta
Sat, Aug 22 - Wed, Aug 26
Delta Logo
6:00 am - 10:58 am
ROC
-
TYS
4h 58m
1 stop
Delta Logo
6:00 am - 11:47 am
TYS
-
ROC
5h 47m
1 stop
$318Delta
Sat, Aug 15 - Sun, Aug 23
American Airlines Logo
3:19 pm - 8:07 pm
ROC
-
TYS
4h 48m
1 stop
American Airlines Logo
5:15 am - 10:07 am
TYS
-
ROC
4h 52m
1 stop
$319American Airlines
Thu, Aug 6 - Mon, Aug 10
American Airlines Logo
10:48 am - 6:04 pm
ROC
-
TYS
7h 16m
1 stop
American Airlines Logo
7:31 pm - 11:19 pm
TYS
-
ROC
3h 48m
1 stop
$325American Airlines
Thu, Aug 20 - Mon, Aug 24
United Airlines Logo
10:19 am - 8:53 pm
ROC
-
TYS
10h 34m
2 stops
United Airlines Logo
5:45 am - 9:38 am
TYS
-
ROC
3h 53m
1 stop
$330United Airlines
Thu, Aug 20 - Mon, Aug 24
Delta Logo
6:03 am - 12:28 pm
ROC
-
TYS
6h 25m
1 stop
Delta Logo
5:22 pm - 10:52 pm
TYS
-
ROC
5h 30m
1 stop
$341Delta
Sat, Aug 15 - Sun, Aug 23

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Delta flights from Rochester to Knoxville

Our best Delta deals on Rochester to Knoxville flight tickets
Delta
Sep 8
ROC6:18 pmGreater Rochester Intl
4h 09m
1 stop
TYS10:27 pmKnoxville McGhee Tyson
Sep 11
TYS6:00 amKnoxville McGhee Tyson
5h 34m
1 stop
ROC11:34 amGreater Rochester Intl
$285
Delta
Aug 22
ROC6:15 pmGreater Rochester Intl
4h 24m
1 stop
TYS10:39 pmKnoxville McGhee Tyson
Aug 26
TYS6:12 pmKnoxville McGhee Tyson
5h 38m
1 stop
ROC11:50 pmGreater Rochester Intl
$291
Delta
Aug 15
ROC6:00 amGreater Rochester Intl
4h 58m
1 stop
TYS10:58 amKnoxville McGhee Tyson
Aug 23
TYS6:00 amKnoxville McGhee Tyson
5h 47m
1 stop
ROC11:47 amGreater Rochester Intl
$318

Southwest flights from Rochester to Knoxville

Our best Southwest deals on Rochester to Knoxville flight tickets
Southwest
Aug 22
ROC6:05 amGreater Rochester Intl
8h 35m
2 stops
TYS2:40 pmKnoxville McGhee Tyson
Aug 29
TYS6:50 amKnoxville McGhee Tyson
9h 00m
2 stops
ROC3:50 pmGreater Rochester Intl
$395
Southwest
Aug 20
ROC6:20 amGreater Rochester Intl
10h 50m
2 stops
TYS5:10 pmKnoxville McGhee Tyson
Aug 24
TYS12:40 pmKnoxville McGhee Tyson
9h 25m
2 stops
ROC10:05 pmGreater Rochester Intl
$403
Southwest
Aug 4
ROC6:05 amGreater Rochester Intl
12h 50m
2 stops
TYS6:55 pmKnoxville McGhee Tyson
Aug 12
TYS12:45 pmKnoxville McGhee Tyson
8h 30m
2 stops
ROC9:15 pmGreater Rochester Intl
$404

momondo Fare Finder

 
Customize your flight search to find flights from Rochester to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 19, 2026.
Use the filters below to find and compare flights from Rochester to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Wed 8/12

5:09 am-10:45 am

1 stop5h 36m

Knoxville McGhee Tyson

Tue 8/18

5:15 am-10:07 am

1 stop4h 52m

$279

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Wed 8/12

10:19 am-8:53 pm

2 stops10h 34m

Knoxville McGhee Tyson

Tue 8/18

9:45 am-2:14 pm

1 stop4h 29m

$284

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Tue 9/8

5:52 pm-12:23 am

1 stop6h 31m

Knoxville McGhee Tyson

Fri 9/11

7:20 pm-11:44 pm

1 stop4h 24m

$285

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Wed 8/26

4:10 pm-11:59 pm

2 stops7h 49m

Knoxville McGhee Tyson

Mon 8/31

7:00 am-2:13 pm

2 stops7h 13m

$290

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Sat 8/22

6:15 pm-10:39 pm

1 stop4h 24m

Knoxville McGhee Tyson

Wed 8/26

6:12 pm-11:50 pm

1 stop5h 38m

$291

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Sat 8/15

6:00 am-10:58 am

1 stop4h 58m

Knoxville McGhee Tyson

Sun 8/23

6:00 am-11:47 am

1 stop5h 47m

$318
Quickest round-trip

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Thu 8/6

3:19 pm-8:07 pm

1 stop4h 48m

Knoxville McGhee Tyson

Mon 8/10

5:15 am-10:07 am

1 stop4h 52m

$319

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Thu 8/20

10:48 am-6:04 pm

1 stop7h 16m

Knoxville McGhee Tyson

Mon 8/24

7:31 pm-11:19 pm

1 stop3h 48m

$325

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Thu 8/20

10:19 am-8:53 pm

2 stops10h 34m

Knoxville McGhee Tyson

Mon 8/24

5:45 am-9:38 am

1 stop3h 53m

$330

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Sat 8/15

6:03 am-12:28 pm

1 stop6h 25m

Knoxville McGhee Tyson

Sun 8/23

5:22 pm-10:52 pm

1 stop5h 30m

$341

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Rochester to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Rochester and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Rochester, with most prices found around $319. If you aren’t able to travel during the month of August, then book flights to Knoxville from Rochester during May instead. Flights to Knoxville in May, while not as cheap as those in August, still average around $336.

When to book flights from Rochester to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Rochester to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Rochester to Knoxville (ROC to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Rochester to Knoxville

Fastest flight time

4h 06m

Direct flights

None
The fastest flight from Rochester to Knoxville takes 4h 06m
There are no direct flights from Rochester to Knoxville. There are no popular flight routes from Rochester to Knoxville.
Search flight deals

Frequently asked questions about flying from Rochester to Knoxville

  • How far is Greater Rochester Intl to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 599.1 mi away from Greater Rochester Intl. 4h 06m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Greater Rochester Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Greater Rochester Intl Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Greater Rochester Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Greater Rochester Intl Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greater Rochester Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Rochester to Knoxville?

Best airlines flying from Rochester to Knoxville

Compare and see reviews for airlines that fly from Rochester to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $155Free CancellationRating
7.8
8,477 reviews
Search Delta flights
United AirlinesPriceFrom $179Free CancellationRating
7.4
10,006 reviews
Search United Airlines flights
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,820 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Maryville
Corbin
Alcoa
Murphy
Crossville
Oak Ridge
Kodak
Newport
Lenoir City
Clinton
Dandridge
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Rochester to Knoxville?

It is quick and easy to find Rochester to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Rochester to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Rochester to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Rochester to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Rochester. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Rochester to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Rochester to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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