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Cheap flights from Rochester to Knoxville from $156

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Rochester to Knoxville departing on 7/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Rochester to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:43 pm - 9:33 pm
ROC
-
TYS
3h 50m
1 stop
American Airlines Logo
7:31 pm - 11:19 pm
TYS
-
ROC
3h 48m
1 stop
$262American Airlines
Tue, Aug 4 - Tue, Aug 11
United Airlines Logo
10:19 am - 2:37 pm
ROC
-
TYS
4h 18m
1 stop
United Airlines Logo
9:45 am - 2:14 pm
TYS
-
ROC
4h 29m
1 stop
$263United Airlines
Sat, Sep 5 - Wed, Sep 9
United Airlines Logo
10:19 am - 8:53 pm
ROC
-
TYS
10h 34m
2 stops
United Airlines Logo
9:45 am - 2:14 pm
TYS
-
ROC
4h 29m
1 stop
$268United Airlines
Sat, Sep 5 - Wed, Sep 9
Southwest Logo
12:40 pm - 7:20 pm
ROC
-
TYS
6h 40m
1 stop
Southwest Logo
7:50 am - 12:20 pm
TYS
-
ROC
4h 30m
1 stop
$280Southwest
Sat, Sep 19 - Sat, Sep 26
Delta Logo
6:15 pm - 11:52 pm
ROC
-
TYS
5h 37m
1 stop
Delta Logo
5:15 pm - 11:23 pm
TYS
-
ROC
6h 08m
1 stop
$299Delta
Mon, Aug 10 - Thu, Aug 20
Delta Logo
6:00 am - 10:58 am
ROC
-
TYS
4h 58m
1 stop
Delta Logo
6:00 am - 11:47 am
TYS
-
ROC
5h 47m
1 stop
$310Delta
Sat, Aug 22 - Sun, Aug 30
Delta Logo
6:00 am - 10:58 am
ROC
-
TYS
4h 58m
1 stop
Delta Logo
7:11 am - 11:54 am
TYS
-
ROC
4h 43m
1 stop
$311Delta
Wed, Aug 5 - Tue, Aug 11
Southwest Logo
12:40 pm - 7:20 pm
ROC
-
TYS
6h 40m
1 stop
Southwest Logo
6:50 am - 3:50 pm
TYS
-
ROC
9h 00m
2 stops
$316Southwest
Sat, Sep 19 - Sat, Sep 26
Delta Logo
6:15 am - 10:20 am
ROC
-
TYS
4h 05m
1 stop
Delta Logo
5:22 pm - 10:52 pm
TYS
-
ROC
5h 30m
1 stop
$323Delta
Wed, Aug 5 - Mon, Aug 10
Delta Logo
6:16 am - 10:22 am
ROC
-
TYS
4h 06m
1 stop
Delta Logo
7:49 pm - 11:48 pm
TYS
-
ROC
3h 59m
1 stop
$326Delta
Tue, Jul 7 - Fri, Jul 10

Southwest flights from Rochester to Knoxville

Our best Southwest deals on Rochester to Knoxville flight tickets
Southwest
Sep 19
ROC12:40 pmGreater Rochester Intl
6h 40m
1 stop
TYS7:20 pmKnoxville McGhee Tyson
Sep 26
TYS7:50 amKnoxville McGhee Tyson
4h 30m
1 stop
ROC12:20 pmGreater Rochester Intl
$280
Southwest
Sep 19
ROC12:40 pmGreater Rochester Intl
6h 40m
1 stop
TYS7:20 pmKnoxville McGhee Tyson
Sep 26
TYS6:50 amKnoxville McGhee Tyson
9h 00m
2 stops
ROC3:50 pmGreater Rochester Intl
$316
Southwest
Jul 1
ROC6:00 amGreater Rochester Intl
11h 00m
2 stops
TYS5:00 pmKnoxville McGhee Tyson
Jul 8
TYS12:45 pmKnoxville McGhee Tyson
10h 05m
2 stops
ROC10:50 pmGreater Rochester Intl
$360

United Airlines flights from Rochester to Knoxville

Our best United Airlines deals on Rochester to Knoxville flight tickets
United Airlines
Sep 5
ROC10:19 amGreater Rochester Intl
4h 18m
1 stop
TYS2:37 pmKnoxville McGhee Tyson
Sep 9
TYS9:45 amKnoxville McGhee Tyson
4h 29m
1 stop
ROC2:14 pmGreater Rochester Intl
$263
United Airlines
Sep 5
ROC10:19 amGreater Rochester Intl
10h 34m
2 stops
TYS8:53 pmKnoxville McGhee Tyson
Sep 9
TYS9:45 amKnoxville McGhee Tyson
4h 29m
1 stop
ROC2:14 pmGreater Rochester Intl
$268
United Airlines
Oct 20
ROC6:05 amGreater Rochester Intl
4h 31m
1 stop
TYS10:36 amKnoxville McGhee Tyson
Oct 24
TYS9:45 amKnoxville McGhee Tyson
8h 27m
2 stops
ROC6:12 pmGreater Rochester Intl
$330

momondo Fare Finder

 
Customize your flight search to find flights from Rochester to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 2, 2026.
Use the filters below to find and compare flights from Rochester to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Tue 8/4

5:43 pm-9:33 pm

1 stop3h 50m

Knoxville McGhee Tyson

Tue 8/11

7:31 pm-11:19 pm

1 stop3h 48m

$262

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Sat 9/5

10:19 am-2:37 pm

1 stop4h 18m

Knoxville McGhee Tyson

Wed 9/9

9:45 am-2:14 pm

1 stop4h 29m

$263

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Sat 9/5

10:19 am-8:53 pm

2 stops10h 34m

Knoxville McGhee Tyson

Wed 9/9

9:45 am-2:14 pm

1 stop4h 29m

$268

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Sat 9/19

12:40 pm-7:20 pm

1 stop6h 40m

Knoxville McGhee Tyson

Sat 9/26

7:50 am-12:20 pm

1 stop4h 30m

$280

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Mon 8/10

6:15 pm-11:52 pm

1 stop5h 37m

Knoxville McGhee Tyson

Thu 8/20

5:15 pm-11:23 pm

1 stop6h 08m

$299

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Sat 8/22

6:00 am-10:58 am

1 stop4h 58m

Knoxville McGhee Tyson

Sun 8/30

6:00 am-11:47 am

1 stop5h 47m

$310

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Wed 8/5

6:00 am-10:58 am

1 stop4h 58m

Knoxville McGhee Tyson

Tue 8/11

7:11 am-11:54 am

1 stop4h 43m

$311

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Sat 9/19

12:40 pm-7:20 pm

1 stop6h 40m

Knoxville McGhee Tyson

Sat 9/26

6:50 am-3:50 pm

2 stops9h 00m

$316

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Wed 8/5

6:15 am-10:20 am

1 stop4h 05m

Knoxville McGhee Tyson

Mon 8/10

5:22 pm-10:52 pm

1 stop5h 30m

$323

RochesterKnoxville

ROC - TYS

ROCTYS

Greater Rochester Intl

Tue 7/7

6:16 am-10:22 am

1 stop4h 06m

Knoxville McGhee Tyson

Fri 7/10

7:49 pm-11:48 pm

1 stop3h 59m

$326

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Rochester to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Rochester and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from Rochester, with most prices found around $298. If you aren’t able to travel during the month of September, then book flights to Knoxville from Rochester during November instead. Flights to Knoxville in November, while not as cheap as those in September, still average around $335.

How far in advance should I book a flight from Rochester to Knoxville?

You are more likely to see cheaper flights to Knoxville from Rochester when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $366 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Rochester for as low as $155 on momondo.

When to book flights from Rochester to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Rochester to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Rochester to Knoxville (ROC to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Rochester to Knoxville

Fastest flight time

3h 50m

Direct flights

None
The fastest flight from Rochester to Knoxville takes 3h 50m
There are no direct flights from Rochester to Knoxville. There are no popular flight routes from Rochester to Knoxville.
Search flight deals

Frequently asked questions about flying from Rochester to Knoxville

  • How far is Greater Rochester Intl to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 599.1 mi away from Greater Rochester Intl. 3h 50m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Greater Rochester Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Greater Rochester Intl Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Greater Rochester Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Greater Rochester Intl Airport to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greater Rochester Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Rochester to Knoxville?

Best airlines flying from Rochester to Knoxville

Compare and see reviews for airlines that fly from Rochester to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $155Free CancellationRating
7.9
8,402 reviews
Search Delta flights
United AirlinesPriceFrom $179Free CancellationRating
7.4
9,768 reviews
Search United Airlines flights
American AirlinesPriceFrom $258Free CancellationRating
7.1
11,641 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Rochester to Knoxville?

It is quick and easy to find Rochester to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Rochester to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Rochester to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Rochester to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Rochester. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Rochester to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Rochester to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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