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Cheap flights from Roanoke to St. Louis from $186

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to St. Louis departing on 6/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Roanoke to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
7:59 pm - 11:56 pm
ROA
-
STL
4h 57m
1 stop
Delta Logo
7:12 pm - 12:32 am
STL
-
ROA
4h 20m
1 stop
$309Delta
Wed, Jul 1 - Mon, Jul 6
American Airlines Logo
7:53 pm - 11:57 pm
ROA
-
STL
5h 04m
1 stop
American Airlines Logo
6:14 am - 2:24 pm
STL
-
ROA
7h 10m
1 stop
$319American Airlines
Thu, Jul 9 - Thu, Jul 23
Delta Logo
7:35 pm - 11:59 pm
ROA
-
STL
5h 24m
1 stop
Delta Logo
7:12 pm - 12:32 am
STL
-
ROA
4h 20m
1 stop
$324Delta
Tue, Jun 2 - Tue, Jun 9
American Airlines Logo
6:04 pm - 11:44 pm
ROA
-
STL
6h 40m
1 stop
American Airlines Logo
5:14 am - 10:45 am
STL
-
ROA
4h 31m
1 stop
$339American Airlines
Tue, May 26 - Sat, May 30
American Airlines Logo
5:51 pm - 12:16 am
ROA
-
STL
7h 25m
2 stops
American Airlines Logo
9:22 am - 5:16 pm
STL
-
ROA
6h 54m
1 stop
$348American Airlines
Wed, Jul 1 - Mon, Jul 6
American Airlines Logo
5:29 pm - 11:59 pm
ROA
-
STL
7h 30m
1 stop
American Airlines Logo
9:14 am - 5:17 pm
STL
-
ROA
7h 03m
1 stop
$373American Airlines
Fri, Aug 28 - Mon, Aug 31
American Airlines Logo
5:51 pm - 12:14 am
ROA
-
STL
7h 23m
2 stops
American Airlines Logo
9:23 am - 5:43 pm
STL
-
ROA
7h 20m
1 stop
$397American Airlines
Wed, Jun 3 - Wed, Jun 10
American Airlines Logo
6:00 am - 2:02 pm
ROA
-
STL
9h 02m
1 stop
American Airlines Logo
9:23 am - 5:17 pm
STL
-
ROA
6h 54m
1 stop
$399American Airlines
Thu, Jun 4 - Thu, Jun 11
American Airlines Logo
5:51 pm - 12:14 am
ROA
-
STL
7h 23m
2 stops
American Airlines Logo
6:15 am - 2:24 pm
STL
-
ROA
7h 09m
1 stop
$402American Airlines
Wed, Jun 3 - Wed, Jun 10
United Airlines Logo
2:45 pm - 6:13 pm
ROA
-
STL
4h 28m
1 stop
United Airlines Logo
7:22 am - 2:08 pm
STL
-
ROA
5h 46m
1 stop
$419United Airlines
Tue, May 26 - Sat, May 30

United Airlines flights from Roanoke to St. Louis

Our best United Airlines deals on Roanoke to St. Louis flight tickets
United Airlines
May 19
ROA10:51 amRoanoke
4h 41m
1 stop
STL2:32 pmLambert-St Louis
May 23
STL10:25 amLambert-St Louis
5h 46m
1 stop
ROA5:11 pmRoanoke
$414
United Airlines
May 26
ROA2:45 pmRoanoke
4h 28m
1 stop
STL6:13 pmLambert-St Louis
May 30
STL7:22 amLambert-St Louis
5h 46m
1 stop
ROA2:08 pmRoanoke
$419
United Airlines
Aug 28
ROA8:05 pmRoanoke
16h 58m
3 stops
STL12:03 pmLambert-St Louis
Aug 31
STL12:59 pmLambert-St Louis
6h 55m
1 stop
ROA8:54 pmRoanoke
$518

American Airlines flights from Roanoke to St. Louis

Our best American Airlines deals on Roanoke to St. Louis flight tickets
American Airlines
Jul 9
ROA7:53 pmRoanoke
5h 04m
1 stop
STL11:57 pmLambert-St Louis
Jul 23
STL6:14 amLambert-St Louis
7h 10m
1 stop
ROA2:24 pmRoanoke
$319
American Airlines
May 26
ROA6:04 pmRoanoke
6h 40m
1 stop
STL11:44 pmLambert-St Louis
May 30
STL5:14 amLambert-St Louis
4h 31m
1 stop
ROA10:45 amRoanoke
$339
American Airlines
Jul 1
ROA5:51 pmRoanoke
7h 25m
2 stops
STL12:16 amLambert-St Louis
Jul 6
STL9:22 amLambert-St Louis
6h 54m
1 stop
ROA5:16 pmRoanoke
$348

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 16, 2026.
Use the filters below to find and compare flights from Roanoke to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Wed 7/1

7:59 pm-11:56 pm

1 stop4h 57m

Lambert-St Louis

Mon 7/6

7:12 pm-12:32 am

1 stop4h 20m

$309

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Thu 7/9

7:53 pm-11:57 pm

1 stop5h 04m

Lambert-St Louis

Thu 7/23

6:14 am-2:24 pm

1 stop7h 10m

$319

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Tue 6/2

7:35 pm-11:59 pm

1 stop5h 24m

Lambert-St Louis

Tue 6/9

7:12 pm-12:32 am

1 stop4h 20m

$324

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Tue 5/26

6:04 pm-11:44 pm

1 stop6h 40m

Lambert-St Louis

Sat 5/30

5:14 am-10:45 am

1 stop4h 31m

$339

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Wed 7/1

5:51 pm-12:16 am

2 stops7h 25m

Lambert-St Louis

Mon 7/6

9:22 am-5:16 pm

1 stop6h 54m

$348

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Fri 8/28

5:29 pm-11:59 pm

1 stop7h 30m

Lambert-St Louis

Mon 8/31

9:14 am-5:17 pm

1 stop7h 03m

$373

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Wed 6/3

5:51 pm-12:14 am

2 stops7h 23m

Lambert-St Louis

Wed 6/10

9:23 am-5:43 pm

1 stop7h 20m

$397

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Thu 6/4

6:00 am-2:02 pm

1 stop9h 02m

Lambert-St Louis

Thu 6/11

9:23 am-5:17 pm

1 stop6h 54m

$399

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Wed 6/3

5:51 pm-12:14 am

2 stops7h 23m

Lambert-St Louis

Wed 6/10

6:15 am-2:24 pm

1 stop7h 09m

$402

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Tue 5/26

2:45 pm-6:13 pm

1 stop4h 28m

Lambert-St Louis

Sat 5/30

7:22 am-2:08 pm

1 stop5h 46m

$419

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Roanoke to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Roanoke and St. Louis?

What is the cheapest month to fly to St. Louis?

In general, February is the cheapest month to fly from Roanoke to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $269. The month of March is another great option to travel to St. Louis, with average flight prices from Roanoke averaging around $289.

Can stopping save me money on Roanoke to St. Louis flights?

You could potentially save up to 28% on your flight if you consider stops on a Roanoke to St. Louis flight.

When to book flights from Roanoke to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to St. Louis (ROA to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to St. Louis

Fastest flight time

4h 56m

Direct flights

None
The fastest flight from Roanoke to St. Louis takes 4h 56m
There are no direct flights from Roanoke to St. Louis. There are no popular flight routes from Roanoke to St. Louis.
Search flight deals

Frequently asked questions about flying from Roanoke to St. Louis

  • How far is Roanoke to Lambert-St Louis by plane?

    The straight-line distance from Roanoke to Lambert-St Louis is 565.9 mi. In terms of flight time, this usually takes a little over 4h 56m.

  • When did momondo last update prices for flights from Roanoke Airport to Lambert-St Louis Airport?

    Prices for flights from Roanoke Airport to Lambert-St Louis Airport were last updated today.

  • How many operators does momondo search for flights from Roanoke Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Roanoke Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Roanoke Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The necessary travel and health documents for your Lambert-St Louis Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Roanoke to St. Louis?

Best airlines flying from Roanoke to St. Louis

Compare and see reviews for airlines that fly from Roanoke to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,726 reviews
Search United Airlines flights
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,662 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,455 reviews
Search Delta flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
St. Peters
Collinsville
Alton
Wentzville
Fenton
Farmington
Festus
Clayton
Eureka
Litchfield
Edwardsville
Shrewsbury
Grafton

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to St. Louis?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to St. Louis from Roanoke.

Can I find flights from Roanoke to St. Louis with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Roanoke to St. Louis flights to just show those with flexible booking policies.

How can momondo help me find flights from Roanoke to St. Louis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to St. Louis from Roanoke.

I’m not ready to book a flight from Roanoke to St. Louis right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to St. Louis from Roanoke. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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