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Cheap flights from Roanoke to St. Louis from $201

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to St. Louis departing on 5/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Roanoke to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
7:50 pm - 11:37 pm
ROA
-
STL
4h 47m
1 stop
Delta Logo
3:42 pm - 11:50 pm
STL
-
ROA
7h 08m
1 stop
$289Delta
Sat, Aug 29 - Mon, Aug 31
Delta Logo
7:51 pm - 11:58 pm
ROA
-
STL
5h 07m
1 stop
Delta Logo
6:59 pm - 12:04 am
STL
-
ROA
4h 05m
1 stop
$309Delta
Fri, Apr 3 - Tue, Apr 7
Delta Logo
7:51 pm - 11:58 pm
ROA
-
STL
5h 07m
1 stop
Delta Logo
6:59 pm - 12:04 am
STL
-
ROA
4h 05m
1 stop
$314Delta
Tue, Mar 31 - Wed, Apr 8
Delta Logo
11:20 am - 3:58 pm
ROA
-
STL
5h 38m
1 stop
Delta Logo
5:30 pm - 11:49 pm
STL
-
ROA
5h 19m
1 stop
$329Delta
Thu, Jul 9 - Thu, Jul 23
United Airlines Logo
5:35 pm - 9:58 pm
ROA
-
STL
5h 23m
1 stop
United Airlines Logo
9:10 am - 5:05 pm
STL
-
ROA
6h 55m
1 stop
$330United Airlines
Fri, Mar 27 - Tue, Mar 31
Delta Logo
6:00 am - 9:05 am
ROA
-
STL
4h 05m
1 stop
Delta Logo
7:03 am - 2:33 pm
STL
-
ROA
6h 30m
1 stop
$344Delta
Thu, Apr 2 - Wed, Apr 8
Delta Logo
7:05 am - 12:22 pm
ROA
-
STL
6h 17m
1 stop
Delta Logo
6:59 pm - 12:04 am
STL
-
ROA
4h 05m
1 stop
$349Delta
Tue, Mar 31 - Thu, Apr 9
Multiple Airlines Logo
3:09 pm - 11:19 pm
ROA
-
STL
9h 10m
1 stop
Multiple Airlines Logo
5:27 pm - 7:48 pm
STL
-
ROA
25h 21m
2 stops
$351Multiple Airlines
Mon, May 4 - Wed, May 6
Delta Logo
7:51 pm - 11:58 pm
ROA
-
STL
5h 07m
1 stop
Delta Logo
5:00 pm - 12:04 am
STL
-
ROA
6h 04m
1 stop
$354Delta
Wed, Apr 1 - Sat, Apr 4
United Airlines Logo
6:40 am - 12:27 pm
ROA
-
STL
6h 47m
1 stop
United Airlines Logo
8:30 am - 2:13 pm
STL
-
ROA
4h 43m
1 stop
$357United Airlines
Sat, Mar 28 - Wed, Apr 1

Delta flights from Roanoke to St. Louis

Our best Delta deals on Roanoke to St. Louis flight tickets
Delta
Aug 29
ROA7:50 pmRoanoke
4h 47m
1 stop
STL11:37 pmLambert-St Louis
Aug 31
STL3:42 pmLambert-St Louis
7h 08m
1 stop
ROA11:50 pmRoanoke
$289
Delta
Apr 3
ROA7:51 pmRoanoke
5h 07m
1 stop
STL11:58 pmLambert-St Louis
Apr 7
STL6:59 pmLambert-St Louis
4h 05m
1 stop
ROA12:04 amRoanoke
$309
Delta
Mar 31
ROA7:51 pmRoanoke
5h 07m
1 stop
STL11:58 pmLambert-St Louis
Apr 8
STL6:59 pmLambert-St Louis
4h 05m
1 stop
ROA12:04 amRoanoke
$314

United Airlines flights from Roanoke to St. Louis

Our best United Airlines deals on Roanoke to St. Louis flight tickets
United Airlines
Mar 27
ROA5:35 pmRoanoke
5h 23m
1 stop
STL9:58 pmLambert-St Louis
Mar 31
STL9:10 amLambert-St Louis
6h 55m
1 stop
ROA5:05 pmRoanoke
$330
United Airlines
Mar 28
ROA6:40 amRoanoke
6h 47m
1 stop
STL12:27 pmLambert-St Louis
Apr 1
STL8:30 amLambert-St Louis
4h 43m
1 stop
ROA2:13 pmRoanoke
$357
United Airlines
Aug 21
ROA6:47 amRoanoke
7h 02m
1 stop
STL12:49 pmLambert-St Louis
Aug 25
STL5:00 amLambert-St Louis
7h 35m
1 stop
ROA1:35 pmRoanoke
$374

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 14, 2026.
Use the filters below to find and compare flights from Roanoke to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Sat 8/29

7:50 pm-11:37 pm

1 stop4h 47m

Lambert-St Louis

Mon 8/31

3:42 pm-11:50 pm

1 stop7h 08m

$289
Quickest round-trip

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Fri 4/3

7:51 pm-11:58 pm

1 stop5h 07m

Lambert-St Louis

Tue 4/7

6:59 pm-12:04 am

1 stop4h 05m

$309

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Tue 3/31

7:51 pm-11:58 pm

1 stop5h 07m

Lambert-St Louis

Wed 4/8

6:59 pm-12:04 am

1 stop4h 05m

$314

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Thu 7/9

11:20 am-3:58 pm

1 stop5h 38m

Lambert-St Louis

Thu 7/23

5:30 pm-11:49 pm

1 stop5h 19m

$329

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Fri 3/27

5:35 pm-9:58 pm

1 stop5h 23m

Lambert-St Louis

Tue 3/31

9:10 am-5:05 pm

1 stop6h 55m

$330

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Thu 4/2

6:00 am-9:05 am

1 stop4h 05m

Lambert-St Louis

Wed 4/8

7:03 am-2:33 pm

1 stop6h 30m

$344

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Tue 3/31

7:05 am-12:22 pm

1 stop6h 17m

Lambert-St Louis

Thu 4/9

6:59 pm-12:04 am

1 stop4h 05m

$349

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Mon 5/4

3:09 pm-11:19 pm

1 stop9h 10m

Lambert-St Louis

Wed 5/6

5:27 pm-7:48 pm

2 stops25h 21m

$351

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Wed 4/1

7:51 pm-11:58 pm

1 stop5h 07m

Lambert-St Louis

Sat 4/4

5:00 pm-12:04 am

1 stop6h 04m

$354

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Sat 3/28

6:40 am-12:27 pm

1 stop6h 47m

Lambert-St Louis

Wed 4/1

8:30 am-2:13 pm

1 stop4h 43m

$357

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Roanoke to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, February is the cheapest month to fly from Roanoke to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $269. The month of August is another great option to travel to St. Louis, with average flight prices from Roanoke averaging around $288.

Can stopping save me money on Roanoke to St. Louis flights?

You could potentially save up to 47% on your flight if you consider stops on a Roanoke to St. Louis flight.

When to book flights from Roanoke to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to St. Louis (ROA to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to St. Louis

Fastest flight time

4h 44m

Direct flights

None
The fastest flight from Roanoke to St. Louis takes 4h 44m
There are no direct flights from Roanoke to St. Louis. There are no popular flight routes from Roanoke to St. Louis.
Search flight deals

  • How far is Roanoke to Lambert-St Louis by plane?

    The straight-line distance from Roanoke to Lambert-St Louis is 565.9 mi. In terms of flight time, this usually takes a little over 4h 44m.

  • When did momondo last update prices for flights from Roanoke Airport to Lambert-St Louis Airport?

    Prices for flights from Roanoke Airport to Lambert-St Louis Airport were last updated today.

  • How many operators does momondo search for flights from Roanoke Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Roanoke Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Roanoke Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The necessary travel and health documents for your Lambert-St Louis Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Roanoke to St. Louis?

Best airlines flying from Roanoke to St. Louis

Compare and see reviews for airlines that fly from Roanoke to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,423 reviews
Search United Airlines flights
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,464 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,291 reviews
Search Delta flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Florissant
Maryland Heights
O'Fallon
Collinsville
St. Peters
Fenton
Alton
Wentzville
Farmington
Edwardsville
Festus
Clayton
Eureka
Litchfield
Glencoe
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to St. Louis?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to St. Louis from Roanoke.

Can I find flights from Roanoke to St. Louis with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Roanoke to St. Louis flights to just show those with flexible booking policies.

How can momondo help me find flights from Roanoke to St. Louis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to St. Louis from Roanoke.

I’m not ready to book a flight from Roanoke to St. Louis right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to St. Louis from Roanoke. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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