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Cheap flights from Roanoke to St. Louis from $245

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to St. Louis departing on 2/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Roanoke to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:33 am - 11:48 pm
ROA
-
STL
17h 15m
1 stop
American Airlines Logo
2:21 pm - 11:57 pm
STL
-
ROA
8h 36m
1 stop
$245American Airlines
Tue, Feb 24 - Tue, Mar 3
American Airlines Logo
6:04 pm - 11:04 pm
ROA
-
STL
6h 00m
1 stop
American Airlines Logo
9:23 am - 11:57 pm
STL
-
ROA
13h 34m
1 stop
$262American Airlines
Tue, Feb 17 - Tue, Feb 24
Delta Logo
6:00 am - 11:09 am
ROA
-
STL
6h 09m
1 stop
Delta Logo
5:21 pm - 12:04 am
STL
-
ROA
5h 43m
1 stop
$269Delta
Mon, Mar 16 - Tue, Mar 31
Delta Logo
7:59 pm - 11:37 pm
ROA
-
STL
4h 38m
1 stop
Delta Logo
6:47 pm - 12:06 am
STL
-
ROA
4h 19m
1 stop
$274Delta
Wed, Feb 11 - Mon, Feb 16
American Airlines Logo
6:04 pm - 10:52 pm
ROA
-
STL
5h 48m
1 stop
American Airlines Logo
6:38 pm - 11:57 pm
STL
-
ROA
4h 19m
1 stop
$279American Airlines
Fri, Feb 13 - Sun, Feb 15
Delta Logo
7:50 pm - 11:37 pm
ROA
-
STL
4h 47m
1 stop
Delta Logo
5:30 pm - 11:50 pm
STL
-
ROA
5h 20m
1 stop
$304Delta
Thu, Jul 9 - Thu, Jul 23
United Airlines Logo
10:15 am - 9:05 pm
ROA
-
STL
11h 50m
2 stops
United Airlines Logo
7:41 am - 8:07 pm
STL
-
ROA
11h 26m
2 stops
$325United Airlines
Tue, Feb 24 - Tue, Mar 3
United Airlines Logo
7:50 pm - 9:07 pm
ROA
-
STL
26h 17m
2 stops
United Airlines Logo
10:00 am - 5:05 pm
STL
-
ROA
6h 05m
1 stop
$357United Airlines
Mon, Mar 16 - Tue, Mar 31
Delta Logo
7:51 pm - 11:58 pm
ROA
-
STL
5h 07m
1 stop
Delta Logo
6:59 pm - 12:19 am
STL
-
ROA
4h 20m
1 stop
$384Delta
Sun, Mar 15 - Mon, Mar 30
United Airlines Logo
7:50 pm - 9:07 pm
ROA
-
STL
26h 17m
2 stops
United Airlines Logo
10:00 am - 5:05 pm
STL
-
ROA
6h 05m
1 stop
$394United Airlines
Mon, Mar 16 - Tue, Mar 31

Delta flights from Roanoke to St. Louis

Our best Delta deals on Roanoke to St. Louis flight tickets
Delta
Mar 16
ROA6:00 amRoanoke
6h 09m
1 stop
STL11:09 amLambert-St Louis
Mar 31
STL5:21 pmLambert-St Louis
5h 43m
1 stop
ROA12:04 amRoanoke
$269
Delta
Feb 11
ROA7:59 pmRoanoke
4h 38m
1 stop
STL11:37 pmLambert-St Louis
Feb 16
STL6:47 pmLambert-St Louis
4h 19m
1 stop
ROA12:06 amRoanoke
$274
Delta
Jul 9
ROA7:50 pmRoanoke
4h 47m
1 stop
STL11:37 pmLambert-St Louis
Jul 23
STL5:30 pmLambert-St Louis
5h 20m
1 stop
ROA11:50 pmRoanoke
$304

American Airlines flights from Roanoke to St. Louis

Our best American Airlines deals on Roanoke to St. Louis flight tickets
American Airlines
Feb 24
ROA7:33 amRoanoke
17h 15m
1 stop
STL11:48 pmLambert-St Louis
Mar 3
STL2:21 pmLambert-St Louis
8h 36m
1 stop
ROA11:57 pmRoanoke
$245
American Airlines
Feb 17
ROA6:04 pmRoanoke
6h 00m
1 stop
STL11:04 pmLambert-St Louis
Feb 24
STL9:23 amLambert-St Louis
13h 34m
1 stop
ROA11:57 pmRoanoke
$262
American Airlines
Feb 13
ROA6:04 pmRoanoke
5h 48m
1 stop
STL10:52 pmLambert-St Louis
Feb 15
STL6:38 pmLambert-St Louis
4h 19m
1 stop
ROA11:57 pmRoanoke
$279

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Roanoke to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Tue 2/24

7:33 am-11:48 pm

1 stop17h 15m

Lambert-St Louis

Tue 3/3

2:21 pm-11:57 pm

1 stop8h 36m

$245

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Tue 2/17

6:04 pm-11:04 pm

1 stop6h 00m

Lambert-St Louis

Tue 2/24

9:23 am-11:57 pm

1 stop13h 34m

$262

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Mon 3/16

6:00 am-11:09 am

1 stop6h 09m

Lambert-St Louis

Tue 3/31

5:21 pm-12:04 am

1 stop5h 43m

$269

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Wed 2/11

7:59 pm-11:37 pm

1 stop4h 38m

Lambert-St Louis

Mon 2/16

6:47 pm-12:06 am

1 stop4h 19m

$274

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Fri 2/13

6:04 pm-10:52 pm

1 stop5h 48m

Lambert-St Louis

Sun 2/15

6:38 pm-11:57 pm

1 stop4h 19m

$279

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Thu 7/9

7:50 pm-11:37 pm

1 stop4h 47m

Lambert-St Louis

Thu 7/23

5:30 pm-11:50 pm

1 stop5h 20m

$304

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Tue 2/24

10:15 am-9:05 pm

2 stops11h 50m

Lambert-St Louis

Tue 3/3

7:41 am-8:07 pm

2 stops11h 26m

$325

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Mon 3/16

7:50 pm-9:07 pm

2 stops26h 17m

Lambert-St Louis

Tue 3/31

10:00 am-5:05 pm

1 stop6h 05m

$357

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Sun 3/15

7:51 pm-11:58 pm

1 stop5h 07m

Lambert-St Louis

Mon 3/30

6:59 pm-12:19 am

1 stop4h 20m

$384

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Mon 3/16

7:50 pm-9:07 pm

2 stops26h 17m

Lambert-St Louis

Tue 3/31

10:00 am-5:05 pm

1 stop6h 05m

$394

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to St. Louis from

How to get the cheapest flight ticket from Roanoke to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Roanoke and St. Louis?

What is the cheapest month to fly to St. Louis?

In general, February is the cheapest month to fly from Roanoke to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $269. The month of August is another great option to travel to St. Louis, with average flight prices from Roanoke averaging around $288.

When to book flights from Roanoke to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to St. Louis (ROA to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to St. Louis

Fastest flight time

4h 06m

Direct flights

None
The fastest flight from Roanoke to St. Louis takes 4h 06m
There are no direct flights from Roanoke to St. Louis. There are no popular flight routes from Roanoke to St. Louis.
Search flight deals

  • How far is Roanoke to Lambert-St Louis by plane?

    The straight-line distance from Roanoke to Lambert-St Louis is 565.9 mi. In terms of flight time, this usually takes a little over 4h 06m.

  • When did momondo last update prices for flights from Roanoke Airport to Lambert-St Louis Airport?

    Prices for flights from Roanoke Airport to Lambert-St Louis Airport were last updated today.

  • How many operators does momondo search for flights from Roanoke Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Roanoke Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Roanoke Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The necessary travel and health documents for your Lambert-St Louis Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Roanoke to St. Louis?

Best airlines flying from Roanoke to St. Louis

Compare and see reviews for airlines that fly from Roanoke to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,214 reviews
Search United Airlines flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,205 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,127 reviews
Search Delta flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
Florissant
O'Fallon
Collinsville
Fenton
St. Peters
Wentzville
Alton
Farmington
Clayton
Edwardsville
Eureka
Festus
Glencoe
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to St. Louis?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to St. Louis from Roanoke.

Can I find flights from Roanoke to St. Louis with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Roanoke to St. Louis flights to just show those with flexible booking policies.

How can momondo help me find flights from Roanoke to St. Louis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to St. Louis from Roanoke.

I’m not ready to book a flight from Roanoke to St. Louis right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to St. Louis from Roanoke. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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