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Cheap flights from Roanoke to St. Louis from $239

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to St. Louis departing on 1/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Roanoke to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:00 am - 11:02 am
ROA
-
STL
6h 02m1 stop
Delta Logo
9:59 am - 3:07 pm
STL
-
ROA
4h 08m1 stop
$239Delta
Sat, Jan 17 - Sat, Jan 24
Delta Logo
7:05 am - 12:19 pm
ROA
-
STL
6h 14m1 stop
Delta Logo
5:00 pm - 12:04 am
STL
-
ROA
6h 04m1 stop
$269Delta
Wed, Mar 18 - Tue, Mar 31
American Airlines Logo
7:08 am - 1:38 pm
ROA
-
STL
7h 30m1 stop
American Airlines Logo
5:00 am - 10:31 am
STL
-
ROA
4h 31m1 stop
$309American Airlines
Sat, Dec 27 - Sat, Jan 3
Delta Logo
11:07 am - 3:53 pm
ROA
-
STL
5h 46m1 stop
Delta Logo
5:15 pm - 10:58 pm
STL
-
ROA
4h 43m1 stop
$334Delta
Wed, Mar 18 - Fri, Mar 27
American Airlines Logo
7:08 am - 1:38 pm
ROA
-
STL
7h 30m1 stop
American Airlines Logo
5:00 am - 10:31 am
STL
-
ROA
4h 31m1 stop
$339American Airlines
Sat, Dec 27 - Sat, Jan 3
United Airlines Logo
6:40 am - 12:27 pm
ROA
-
STL
6h 47m1 stop
United Airlines Logo
8:15 am - 2:16 pm
STL
-
ROA
5h 01m1 stop
$349United Airlines
Tue, Dec 30 - Sat, Jan 3
Delta Logo
11:07 am - 3:53 pm
ROA
-
STL
5h 46m1 stop
Delta Logo
5:00 pm - 12:04 am
STL
-
ROA
6h 04m1 stop
$364Delta
Wed, Mar 18 - Sat, Mar 28
Delta Logo
6:00 am - 8:43 pm
ROA
-
STL
15h 43m2 stops
Delta Logo
5:00 pm - 12:04 am
STL
-
ROA
6h 04m1 stop
$374Delta
Wed, Mar 18 - Wed, Mar 25
United Airlines Logo
5:39 pm - 9:13 pm
ROA
-
STL
4h 34m1 stop
United Airlines Logo
3:11 pm - 2:09 pm
STL
-
ROA
21h 58m2 stops
$394United Airlines
Sat, Jan 17 - Sat, Jan 24
Delta Logo
11:07 am - 3:53 pm
ROA
-
STL
5h 46m1 stop
Delta Logo
6:00 am - 10:58 pm
STL
-
ROA
15h 58m2 stops
$400Delta
Wed, Mar 18 - Thu, Mar 26

American Airlines flights from Roanoke to St. Louis

Our best American Airlines deals on Roanoke to St. Louis flight tickets
American Airlines
Dec 27
ROA7:08 amRoanoke
7h 30m
1 stop
STL1:38 pmLambert-St Louis
Jan 3
STL5:00 amLambert-St Louis
4h 31m
1 stop
ROA10:31 amRoanoke
$309
Find similar
American Airlines
Dec 27
ROA7:08 amRoanoke
7h 30m
1 stop
STL1:38 pmLambert-St Louis
Jan 3
STL5:00 amLambert-St Louis
4h 31m
1 stop
ROA10:31 amRoanoke
$339
Find similar
American Airlines
Jan 14
ROA6:00 amRoanoke
4h 40m
1 stop
STL9:40 amLambert-St Louis
Jan 17
STL3:54 pmLambert-St Louis
6h 48m
1 stop
ROA11:42 pmRoanoke
$403
Find similar

United Airlines flights from Roanoke to St. Louis

Our best United Airlines deals on Roanoke to St. Louis flight tickets
United Airlines
Dec 30
ROA6:40 amRoanoke
6h 47m
1 stop
STL12:27 pmLambert-St Louis
Jan 3
STL8:15 amLambert-St Louis
5h 01m
1 stop
ROA2:16 pmRoanoke
$349
Find similar
United Airlines
Jan 17
ROA5:39 pmRoanoke
4h 34m
1 stop
STL9:13 pmLambert-St Louis
Jan 24
STL3:11 pmLambert-St Louis
21h 58m
2 stops
ROA2:09 pmRoanoke
$394
Find similar
United Airlines
Mar 19
ROA6:40 amRoanoke
6h 47m
1 stop
STL12:27 pmLambert-St Louis
Mar 26
STL5:00 amLambert-St Louis
4h 08m
1 stop
ROA10:08 amRoanoke
$523
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Roanoke to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Sat 1/17

6:00 am-11:02 am

1 stop6h 02m

Lambert-St Louis

Sat 1/24

9:59 am-3:07 pm

1 stop4h 08m

$239

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Wed 3/18

7:05 am-12:19 pm

1 stop6h 14m

Lambert-St Louis

Tue 3/31

5:00 pm-12:04 am

1 stop6h 04m

$269

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Sat 12/27

7:08 am-1:38 pm

1 stop7h 30m

Lambert-St Louis

Sat 1/3

5:00 am-10:31 am

1 stop4h 31m

$309

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Wed 3/18

11:07 am-3:53 pm

1 stop5h 46m

Lambert-St Louis

Fri 3/27

5:15 pm-10:58 pm

1 stop4h 43m

$334

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Sat 12/27

7:08 am-1:38 pm

1 stop7h 30m

Lambert-St Louis

Sat 1/3

5:00 am-10:31 am

1 stop4h 31m

$339

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Tue 12/30

6:40 am-12:27 pm

1 stop6h 47m

Lambert-St Louis

Sat 1/3

8:15 am-2:16 pm

1 stop5h 01m

$349

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Wed 3/18

11:07 am-3:53 pm

1 stop5h 46m

Lambert-St Louis

Sat 3/28

5:00 pm-12:04 am

1 stop6h 04m

$364

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Wed 3/18

6:00 am-8:43 pm

2 stops15h 43m

Lambert-St Louis

Wed 3/25

5:00 pm-12:04 am

1 stop6h 04m

$374

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Sat 1/17

5:39 pm-9:13 pm

1 stop4h 34m

Lambert-St Louis

Sat 1/24

3:11 pm-2:09 pm

2 stops21h 58m

$394

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Wed 3/18

11:07 am-3:53 pm

1 stop5h 46m

Lambert-St Louis

Thu 3/26

6:00 am-10:58 pm

2 stops15h 58m

$400

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Roanoke to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, August is the cheapest month to fly from Roanoke to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $288. The month of September is another great option to travel to St. Louis, with average flight prices from Roanoke averaging around $308.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Tuesday when prices can be found for as low as $316. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $582. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Roanoke in the evening is the least expensive time of day to depart. momondo users have found prices as low as $269 when looking at flights departing in the evening. In the afternoon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $462 per ticket.

When to book flights from Roanoke to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to St. Louis (ROA to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to St. Louis

Fastest flight time

4h 23m

Direct flights

None
The fastest flight from Roanoke to St. Louis takes 4h 23m
There are no direct flights from Roanoke to St. Louis. There are no popular flight routes from Roanoke to St. Louis.
Search flight deals

  • How far is Roanoke to Lambert-St Louis by plane?

    The straight-line distance from Roanoke to Lambert-St Louis is 565.9 mi. In terms of flight time, this usually takes a little over 4h 23m.

  • When did momondo last update prices for flights from Roanoke Airport to Lambert-St Louis Airport?

    Prices for flights from Roanoke Airport to Lambert-St Louis Airport were last updated today.

  • How many operators does momondo search for flights from Roanoke Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Roanoke Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Roanoke Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The necessary travel and health documents for your Lambert-St Louis Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Roanoke to St. Louis?

Best airlines flying from Roanoke to St. Louis

Compare and see reviews for airlines that fly from Roanoke to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,092 reviews
Search United Airlines flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,052 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,008 reviews
Search Delta flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
Fenton
Wentzville
St. Peters
Collinsville
Alton
Clayton
Festus
Glencoe
Farmington
Eureka
Edwardsville
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to St. Louis?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to St. Louis from Roanoke.

Can I find flights from Roanoke to St. Louis with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Roanoke to St. Louis flights to just show those with flexible booking policies.

How can momondo help me find flights from Roanoke to St. Louis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to St. Louis from Roanoke.

I’m not ready to book a flight from Roanoke to St. Louis right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to St. Louis from Roanoke. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your St. Louis trip

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