Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Roanoke to St. Louis from $249

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to St. Louis departing on 2/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Roanoke to St. Louis

Cheap round-trip flights

Delta Logo
7:50 pm - 11:40 pmROA-STL
4h 50m1 stop
Delta Logo
10:00 am - 2:39 pmSTL-ROA
3h 39m1 stop
$249Delta
Find Deal
Sat, Feb 21 - Tue, Feb 24
Delta Logo
6:00 am - 8:44 amROA-STL
3h 44m1 stop
Delta Logo
5:25 pm - 12:09 amSTL-ROA
5h 44m1 stop
$254Delta
Find Deal
Sat, Oct 4 - Sat, Oct 11
Delta Logo
7:05 am - 12:19 pmROA-STL
6h 14m1 stop
Delta Logo
5:15 pm - 12:09 amSTL-ROA
5h 54m1 stop
$259Delta
Find Deal
Thu, Oct 2 - Mon, Oct 6
American Airlines Logo
5:28 pm - 11:49 pmROA-STL
7h 21m2 stops
American Airlines Logo
4:25 pm - 10:25 pmSTL-ROA
5h 00m1 stop
$264American Airlines
Find Deal
Thu, Oct 2 - Mon, Oct 6
American Airlines Logo
8:18 pm - 11:58 pmROA-STL
4h 40m1 stop
American Airlines Logo
5:30 am - 10:42 amSTL-ROA
4h 12m1 stop
$309American Airlines
Find Deal
Thu, Oct 9 - Sun, Oct 12
United Airlines Logo
6:45 am - 10:49 amROA-STL
5h 04m1 stop
United Airlines Logo
3:23 pm - 9:41 pmSTL-ROA
5h 18m1 stop
$329United Airlines
Find Deal
Fri, Oct 3 - Tue, Oct 7
United Airlines Logo
5:38 pm - 10:45 pmROA-STL
6h 07m1 stop
United Airlines Logo
8:25 am - 2:12 pmSTL-ROA
4h 47m1 stop
$364United Airlines
Find Deal
Tue, Nov 18 - Sun, Nov 23
United Airlines Logo
6:45 am - 10:49 amROA-STL
5h 04m1 stop
United Airlines Logo
6:43 pm - 2:12 pmSTL-ROA
18h 29m2 stops
$377United Airlines
Find Deal
Tue, Oct 21 - Mon, Oct 27
American Airlines Logo
8:00 pm - 11:55 pmROA-STL
4h 55m1 stop
American Airlines Logo
7:05 am - 2:22 pmSTL-ROA
6h 17m1 stop
$491American Airlines
Find Deal
Fri, Dec 26 - Sun, Dec 28
American Airlines Logo
7:00 am - 1:05 pmROA-STL
7h 05m1 stop
American Airlines Logo
6:45 pm - 12:05 amSTL-ROA
4h 20m1 stop
$535American Airlines
Find Deal
Wed, Nov 19 - Sun, Nov 30

American Airlines flights from Roanoke to St. Louis

Our best American Airlines deals on Roanoke to St. Louis flight tickets
American Airlines
Oct 2
ROA5:28 pmRoanoke
7h 21m
2 stops
STL11:49 pmLambert-St Louis
Oct 6
STL4:25 pmLambert-St Louis
5h 00m
1 stop
ROA10:25 pmRoanoke
$264
Find similar
American Airlines
Oct 9
ROA8:18 pmRoanoke
4h 40m
1 stop
STL11:58 pmLambert-St Louis
Oct 12
STL5:30 amLambert-St Louis
4h 12m
1 stop
ROA10:42 amRoanoke
$309
Find similar
American Airlines
Dec 26
ROA8:00 pmRoanoke
4h 55m
1 stop
STL11:55 pmLambert-St Louis
Dec 28
STL7:05 amLambert-St Louis
6h 17m
1 stop
ROA2:22 pmRoanoke
$491
Find similar

Delta flights from Roanoke to St. Louis

Our best Delta deals on Roanoke to St. Louis flight tickets
Delta
Feb 21
ROA7:50 pmRoanoke
4h 50m
1 stop
STL11:40 pmLambert-St Louis
Feb 24
STL10:00 amLambert-St Louis
3h 39m
1 stop
ROA2:39 pmRoanoke
$249
Find similar
Delta
Oct 4
ROA6:00 amRoanoke
3h 44m
1 stop
STL8:44 amLambert-St Louis
Oct 11
STL5:25 pmLambert-St Louis
5h 44m
1 stop
ROA12:09 amRoanoke
$254
Find similar
Delta
Oct 2
ROA7:05 amRoanoke
6h 14m
1 stop
STL12:19 pmLambert-St Louis
Oct 6
STL5:15 pmLambert-St Louis
5h 54m
1 stop
ROA12:09 amRoanoke
$259
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 18, 2025.
Use the filters below to find and compare flights from Roanoke to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Sat 2/21

7:50 pm-11:40 pm

1 stop4h 50m

Lambert-St Louis

Tue 2/24

10:00 am-2:39 pm

1 stop3h 39m

$249

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Sat 10/4

6:00 am-8:44 am

1 stop3h 44m

Lambert-St Louis

Sat 10/11

5:25 pm-12:09 am

1 stop5h 44m

$254

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Thu 10/2

7:05 am-12:19 pm

1 stop6h 14m

Lambert-St Louis

Mon 10/6

5:15 pm-12:09 am

1 stop5h 54m

$259

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Thu 10/2

5:28 pm-11:49 pm

2 stops7h 21m

Lambert-St Louis

Mon 10/6

4:25 pm-10:25 pm

1 stop5h 00m

$264

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Thu 10/9

8:18 pm-11:58 pm

1 stop4h 40m

Lambert-St Louis

Sun 10/12

5:30 am-10:42 am

1 stop4h 12m

$309

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Fri 10/3

6:45 am-10:49 am

1 stop5h 04m

Lambert-St Louis

Tue 10/7

3:23 pm-9:41 pm

1 stop5h 18m

$329

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Tue 11/18

5:38 pm-10:45 pm

1 stop6h 07m

Lambert-St Louis

Sun 11/23

8:25 am-2:12 pm

1 stop4h 47m

$364

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Tue 10/21

6:45 am-10:49 am

1 stop5h 04m

Lambert-St Louis

Mon 10/27

6:43 pm-2:12 pm

2 stops18h 29m

$377

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Fri 12/26

8:00 pm-11:55 pm

1 stop4h 55m

Lambert-St Louis

Sun 12/28

7:05 am-2:22 pm

1 stop6h 17m

$491

RoanokeSt. Louis

ROA - STL

ROASTL

Roanoke

Wed 11/19

7:00 am-1:05 pm

1 stop7h 05m

Lambert-St Louis

Sun 11/30

6:45 pm-12:05 am

1 stop4h 20m

$535

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

See travel insights to St. Louis from

How to get the cheapest flight ticket from Roanoke to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, August is the cheapest month to fly from Roanoke to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $288. The month of September is another great option to travel to St. Louis, with average flight prices from Roanoke averaging around $308.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Tuesday when prices can be found for as low as $316. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $582. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Roanoke in the evening is the least expensive time of day to depart. momondo users have found prices as low as $269 when looking at flights departing in the evening. In the afternoon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $462 per ticket.

When to book flights from Roanoke to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to St. Louis (ROA to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to St. Louis

Direct flights

None
There are no direct flights from Roanoke to St. Louis. There are no popular flight routes from Roanoke to St. Louis.
Search flight deals

  • How far is Roanoke to Lambert-St Louis by plane?

    The straight-line distance from Roanoke to Lambert-St Louis is 565.9 mi. In terms of flight time, this usually takes a little over 3h 44m.

  • When did momondo last update prices for flights from Roanoke Airport to Lambert-St Louis Airport?

    Prices for flights from Roanoke Airport to Lambert-St Louis Airport were last updated today.

  • How many operators does momondo search for flights from Roanoke Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Roanoke Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Roanoke Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The necessary travel and health documents for your Lambert-St Louis Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Roanoke to St. Louis?

Best airlines flying from Roanoke to St. Louis

Compare and see reviews for airlines that fly from Roanoke to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
7,964 reviews
Search Delta flights
United AirlinesPriceFrom $248Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Florissant
Maryland Heights
O'Fallon
Fenton
Collinsville
Wentzville
Alton
St. Peters
Farmington
Festus
Glencoe
Clayton
Edwardsville
Eureka
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to St. Louis?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to St. Louis from Roanoke.

Can I find flights from Roanoke to St. Louis with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Roanoke to St. Louis flights to just show those with flexible booking policies.

How can momondo help me find flights from Roanoke to St. Louis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to St. Louis from Roanoke.

I’m not ready to book a flight from Roanoke to St. Louis right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to St. Louis from Roanoke. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your St. Louis trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 10/18
Sat 10/25
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States