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Cheap flights from Roanoke to St. Louis from $274

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to St. Louis departing on 9/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Roanoke to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
4:49 pm - 9:13 pmROA  Roanoke-STL Lambert-St Louis
5h 24m1 stop Chicago O'Hare Intl
American Airlines Logo
5:28 am - 10:29 amSTL  Lambert-St Louis-ROA Roanoke
4h 01m1 stop Charlotte Douglas
$319American Airlines
Sat, Oct 24 - Thu, Oct 29
American Airlines Logo
3:29 pm - 9:43 pmROA  Roanoke-STL Lambert-St Louis
7h 14m1 stop Philadelphia
American Airlines Logo
5:15 am - 12:23 pmSTL  Lambert-St Louis-ROA Roanoke
6h 08m1 stop Charlotte Douglas
$319American Airlines
Fri, Sep 18 - Sun, Sep 27
Delta Logo
3:32 pm - 9:14 pmROA  Roanoke-STL Lambert-St Louis
6h 42m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 12:33 pmSTL  Lambert-St Louis-ROA Roanoke
5h 33m1 stop Atlanta Hartsfield-Jackson
$319Delta
Tue, Oct 27 - Sat, Oct 31
Delta Logo
6:00 am - 9:09 amROA  Roanoke-STL Lambert-St Louis
4h 09m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:20 pm - 12:27 amSTL  Lambert-St Louis-ROA Roanoke
4h 07m1 stop Atlanta Hartsfield-Jackson
$319Delta
Thu, Oct 22 - Tue, Oct 27
Delta Logo
6:00 am - 10:51 amROA  Roanoke-STL Lambert-St Louis
5h 51m1 stop Atlanta Hartsfield-Jackson
Delta Logo
10:14 am - 5:58 pmSTL  Lambert-St Louis-ROA Roanoke
6h 44m1 stop Atlanta Hartsfield-Jackson
$319Delta
Thu, Oct 22 - Wed, Oct 28
American Airlines Logo
4:49 pm - 8:57 pmROA  Roanoke-STL Lambert-St Louis
5h 08m1 stop Chicago O'Hare Intl
American Airlines Logo
6:00 am - 1:48 pmSTL  Lambert-St Louis-ROA Roanoke
6h 48m1 stop Philadelphia
$319American Airlines
Fri, Oct 9 - Mon, Oct 12
American Airlines Logo
5:07 pm - 10:42 pmROA  Roanoke-STL Lambert-St Louis
6h 35m1 stop Charlotte Douglas
American Airlines Logo
6:30 am - 1:51 pmSTL  Lambert-St Louis-ROA Roanoke
6h 21m1 stop Philadelphia
$319American Airlines
Fri, Sep 11 - Sun, Sep 13
United Airlines Logo
5:51 pm - 9:21 pmROA  Roanoke-STL Lambert-St Louis
4h 30m1 stop Chicago O'Hare Intl
United Airlines Logo
5:36 pm - 10:59 pmSTL  Lambert-St Louis-ROA Roanoke
4h 23m1 stop Chicago O'Hare Intl
$334United Airlines
Fri, Oct 9 - Mon, Oct 12
United Airlines Logo
2:13 pm - 6:06 pmROA  Roanoke-STL Lambert-St Louis
4h 53m1 stop Chicago O'Hare Intl
United Airlines Logo
6:00 am - 1:33 pmSTL  Lambert-St Louis-ROA Roanoke
6h 33m1 stop Chicago O'Hare Intl
$394United Airlines
Sat, Jan 23 - Wed, Jan 27
United Airlines Logo
5:38 pm - 11:09 pmROA  Roanoke-STL Lambert-St Louis
6h 31m1 stop Chicago O'Hare Intl
United Airlines Logo
5:00 am - 1:33 pmSTL  Lambert-St Louis-ROA Roanoke
7h 33m1 stop Chicago O'Hare Intl
$399United Airlines
Sat, Jan 23 - Wed, Jan 27

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Delta flights from Roanoke to St. Louis

Our best Delta deals on Roanoke to St. Louis flight tickets
Delta
Oct 3
ROA4:46 pmRoanoke
4h 12m
1 stop
STL7:58 pmLambert-St Louis
Oct 10
STL10:47 amLambert-St Louis
5h 41m
1 stop
ROA5:28 pmRoanoke
$319
Delta
Oct 9
ROA6:59 pmRoanoke
5h 55m
1 stop
STL11:54 pmLambert-St Louis
Oct 11
STL7:20 pmLambert-St Louis
4h 07m
1 stop
ROA12:27 amRoanoke
$334
Delta
Oct 8
ROA11:12 amRoanoke
13h 42m
1 stop
STL11:54 pmLambert-St Louis
Oct 12
STL5:35 pmLambert-St Louis
5h 52m
1 stop
ROA12:27 amRoanoke
$352

United Airlines flights from Roanoke to St. Louis

Our best United Airlines deals on Roanoke to St. Louis flight tickets
United Airlines
Jan 23
ROA2:13 pmRoanoke
4h 53m
1 stop
STL6:06 pmLambert-St Louis
Jan 27
STL6:00 amLambert-St Louis
6h 33m
1 stop
ROA1:33 pmRoanoke
$394
United Airlines
Jan 23
ROA5:38 pmRoanoke
6h 31m
1 stop
STL11:09 pmLambert-St Louis
Jan 27
STL5:00 amLambert-St Louis
7h 33m
1 stop
ROA1:33 pmRoanoke
$399
United Airlines
Aug 21
ROA5:50 pmRoanoke
6h 09m
1 stop
STL10:59 pmLambert-St Louis
Aug 24
STL12:59 pmLambert-St Louis
7h 00m
1 stop
ROA8:59 pmRoanoke
$409

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2026.
Use the filters below to find and compare flights from Roanoke to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RoanokeSt. Louis

ROA Roanoke - STL Lambert-St Louis

ROASTL

Roanoke

Sat 10/24

4:49 pm-9:13 pm

1 stop5h 24m

Lambert-St Louis

Thu 10/29

5:28 am-10:29 am

1 stop4h 01m

$319

RoanokeSt. Louis

ROA Roanoke - STL Lambert-St Louis

ROASTL

Roanoke

Fri 9/18

3:29 pm-9:43 pm

1 stop7h 14m

Lambert-St Louis

Sun 9/27

5:15 am-12:23 pm

1 stop6h 08m

$319

RoanokeSt. Louis

ROA Roanoke - STL Lambert-St Louis

ROASTL

Roanoke

Tue 10/27

3:32 pm-9:14 pm

1 stop6h 42m

Lambert-St Louis

Sat 10/31

6:00 am-12:33 pm

1 stop5h 33m

$319
Quickest round-trip

RoanokeSt. Louis

ROA Roanoke - STL Lambert-St Louis

ROASTL

Roanoke

Thu 10/22

6:00 am-9:09 am

1 stop4h 09m

Lambert-St Louis

Tue 10/27

7:20 pm-12:27 am

1 stop4h 07m

$319

RoanokeSt. Louis

ROA Roanoke - STL Lambert-St Louis

ROASTL

Roanoke

Thu 10/22

6:00 am-10:51 am

1 stop5h 51m

Lambert-St Louis

Wed 10/28

10:14 am-5:58 pm

1 stop6h 44m

$319

RoanokeSt. Louis

ROA Roanoke - STL Lambert-St Louis

ROASTL

Roanoke

Fri 10/9

4:49 pm-8:57 pm

1 stop5h 08m

Lambert-St Louis

Mon 10/12

6:00 am-1:48 pm

1 stop6h 48m

$319

RoanokeSt. Louis

ROA Roanoke - STL Lambert-St Louis

ROASTL

Roanoke

Fri 9/11

5:07 pm-10:42 pm

1 stop6h 35m

Lambert-St Louis

Sun 9/13

6:30 am-1:51 pm

1 stop6h 21m

$319

RoanokeSt. Louis

ROA Roanoke - STL Lambert-St Louis

ROASTL

Roanoke

Fri 10/9

5:51 pm-9:21 pm

1 stop4h 30m

Lambert-St Louis

Mon 10/12

5:36 pm-10:59 pm

1 stop4h 23m

$334

RoanokeSt. Louis

ROA Roanoke - STL Lambert-St Louis

ROASTL

Roanoke

Sat 1/23

2:13 pm-6:06 pm

1 stop4h 53m

Lambert-St Louis

Wed 1/27

6:00 am-1:33 pm

1 stop6h 33m

$394

RoanokeSt. Louis

ROA Roanoke - STL Lambert-St Louis

ROASTL

Roanoke

Sat 1/23

5:38 pm-11:09 pm

1 stop6h 31m

Lambert-St Louis

Wed 1/27

5:00 am-1:33 pm

1 stop7h 33m

$399

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Roanoke to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, February is the cheapest month to fly from Roanoke to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $269. The month of March is another great option to travel to St. Louis, with average flight prices from Roanoke averaging around $289.

Can stopping save me money on Roanoke to St. Louis flights?

You could potentially save up to 58% on your flight if you consider stops on a Roanoke to St. Louis flight.

When to book flights from Roanoke to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to St. Louis (ROA to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to St. Louis

Fastest flight time

5h 55m

Direct flights

None
The fastest flight from Roanoke to St. Louis takes 5h 55m
There are no direct flights from Roanoke to St. Louis. There are no popular flight routes from Roanoke to St. Louis.
Search flight deals

Frequently asked questions about flying from Roanoke to St. Louis

  • How far is Roanoke to Lambert-St Louis by plane?

    The straight-line distance from Roanoke to Lambert-St Louis is 565.9 mi. In terms of flight time, this usually takes a little over 5h 55m.

  • When did momondo last update prices for flights from Roanoke Airport to Lambert-St Louis Airport?

    Prices for flights from Roanoke Airport to Lambert-St Louis Airport were last updated today.

  • How many operators does momondo search for flights from Roanoke Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Roanoke Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Roanoke Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The necessary travel and health documents for your Lambert-St Louis Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Roanoke to St. Louis?

Best airlines flying from Roanoke to St. Louis

Compare and see reviews for airlines that fly from Roanoke to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $248Free CancellationRating
7.4
10,108 reviews
Search United Airlines flights
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,929 reviews
Search American Airlines flights
DeltaPriceFrom $254Free CancellationRating
7.8
8,502 reviews
Search Delta flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Fairview Heights
Hermann
St. Peters
Maryland Heights
Collinsville
Florissant
Alton
O'Fallon
Farmington
Clayton
Fenton
Festus
Wentzville
Eureka
Edwardsville
Litchfield
Grafton
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to St. Louis?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to St. Louis from Roanoke.

Can I find flights from Roanoke to St. Louis with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Roanoke to St. Louis flights to just show those with flexible booking policies.

How can momondo help me find flights from Roanoke to St. Louis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to St. Louis from Roanoke.

I’m not ready to book a flight from Roanoke to St. Louis right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to St. Louis from Roanoke. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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