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Cheap flights from Roanoke to Panama City from $249

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to Panama City departing on 1/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Roanoke to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
7:05 am - 12:10 pm
ROA
-
ECP
6h 05m1 stop
Delta Logo
6:00 am - 10:39 am
ECP
-
ROA
3h 39m1 stop
$249Delta
Mon, Jan 5 - Mon, Jan 12
American Airlines Logo
12:43 pm - 5:30 pm
ROA
-
ECP
5h 47m1 stop
American Airlines Logo
12:03 pm - 8:31 pm
ECP
-
ROA
7h 28m2 stops
$254American Airlines
Sat, Jan 24 - Tue, Jan 27
Delta Logo
6:00 am - 9:14 am
ROA
-
ECP
4h 14m1 stop
Delta Logo
7:02 pm - 12:07 am
ECP
-
ROA
4h 05m1 stop
$309Delta
Fri, Dec 19 - Sun, Dec 21
Delta Logo
6:00 am - 9:14 am
ROA
-
ECP
4h 14m1 stop
Delta Logo
7:02 pm - 12:07 am
ECP
-
ROA
4h 05m1 stop
$339Delta
Fri, Dec 19 - Sat, Dec 20
Delta Logo
6:00 am - 8:41 am
ROA
-
ECP
3h 41m1 stop
Delta Logo
6:00 am - 10:27 am
ECP
-
ROA
3h 27m1 stop
$369Delta
Fri, Feb 27 - Sun, Mar 8
Delta Logo
7:03 pm - 10:44 pm
ROA
-
ECP
4h 41m1 stop
Delta Logo
2:04 pm - 8:38 pm
ECP
-
ROA
5h 34m1 stop
$384Delta
Sun, Dec 21 - Wed, Dec 31
American Airlines Logo
7:07 pm - 11:58 pm
ROA
-
ECP
5h 51m1 stop
American Airlines Logo
12:03 pm - 8:31 pm
ECP
-
ROA
7h 28m2 stops
$388American Airlines
Sat, Jan 3 - Sat, Jan 10
American Airlines Logo
6:00 am - 10:37 am
ROA
-
ECP
5h 37m1 stop
American Airlines Logo
12:03 pm - 8:31 pm
ECP
-
ROA
7h 28m2 stops
$391American Airlines
Mon, Jan 5 - Mon, Jan 12
Delta Logo
7:03 pm - 10:44 pm
ROA
-
ECP
4h 41m1 stop
Delta Logo
7:02 pm - 12:07 am
ECP
-
ROA
4h 05m1 stop
$399Delta
Sun, Dec 21 - Sun, Dec 28
American Airlines Logo
6:00 am - 10:37 am
ROA
-
ECP
5h 37m1 stop
American Airlines Logo
4:09 pm - 9:20 pm
ECP
-
ROA
4h 11m1 stop
$431American Airlines
Wed, Dec 24 - Mon, Dec 29

Delta flights from Roanoke to Panama City, Florida

Our best Delta deals on Roanoke to Panama City, Florida flight tickets
Delta
Jan 5
ROA7:05 amRoanoke
6h 05m
1 stop
ECP12:10 pmPanama City NW Florida Beaches
Jan 12
ECP6:00 amPanama City NW Florida Beaches
3h 39m
1 stop
ROA10:39 amRoanoke
$249
Find similar
Delta
Dec 19
ROA6:00 amRoanoke
4h 14m
1 stop
ECP9:14 amPanama City NW Florida Beaches
Dec 21
ECP7:02 pmPanama City NW Florida Beaches
4h 05m
1 stop
ROA12:07 amRoanoke
$309
Find similar
Delta
Dec 13
ROA8:00 pmRoanoke
3h 37m
1 stop
ECP10:37 pmPanama City NW Florida Beaches
Dec 21
ECP7:02 pmPanama City NW Florida Beaches
4h 05m
1 stop
ROA12:07 amRoanoke
$324
Find similar

American Airlines flights from Roanoke to Panama City, Florida

Our best American Airlines deals on Roanoke to Panama City, Florida flight tickets
American Airlines
Jan 24
ROA12:43 pmRoanoke
5h 47m
1 stop
ECP5:30 pmPanama City NW Florida Beaches
Jan 27
ECP12:03 pmPanama City NW Florida Beaches
7h 28m
2 stops
ROA8:31 pmRoanoke
$254
Find similar
American Airlines
Jan 3
ROA7:07 pmRoanoke
5h 51m
1 stop
ECP11:58 pmPanama City NW Florida Beaches
Jan 10
ECP12:03 pmPanama City NW Florida Beaches
7h 28m
2 stops
ROA8:31 pmRoanoke
$388
Find similar
American Airlines
Jan 5
ROA6:00 amRoanoke
5h 37m
1 stop
ECP10:37 amPanama City NW Florida Beaches
Jan 12
ECP12:03 pmPanama City NW Florida Beaches
7h 28m
2 stops
ROA8:31 pmRoanoke
$391
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 9, 2025.
Use the filters below to find and compare flights from Roanoke to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RoanokePanama City

ROA - ECP

ROAECP

Roanoke

Mon 1/5

7:05 am-12:10 pm

1 stop6h 05m

Panama City NW Florida Beaches

Mon 1/12

6:00 am-10:39 am

1 stop3h 39m

$249

RoanokePanama City

ROA - ECP

ROAECP

Roanoke

Sat 1/24

12:43 pm-5:30 pm

1 stop5h 47m

Panama City NW Florida Beaches

Tue 1/27

12:03 pm-8:31 pm

2 stops7h 28m

$254

RoanokePanama City

ROA - ECP

ROAECP

Roanoke

Fri 12/19

6:00 am-9:14 am

1 stop4h 14m

Panama City NW Florida Beaches

Sun 12/21

7:02 pm-12:07 am

1 stop4h 05m

$309

RoanokePanama City

ROA - ECP

ROAECP

Roanoke

Fri 12/19

6:00 am-9:14 am

1 stop4h 14m

Panama City NW Florida Beaches

Sat 12/20

7:02 pm-12:07 am

1 stop4h 05m

$339

RoanokePanama City

ROA - ECP

ROAECP

Roanoke

Fri 2/27

6:00 am-8:41 am

1 stop3h 41m

Panama City NW Florida Beaches

Sun 3/8

6:00 am-10:27 am

1 stop3h 27m

$369

RoanokePanama City

ROA - ECP

ROAECP

Roanoke

Sun 12/21

7:03 pm-10:44 pm

1 stop4h 41m

Panama City NW Florida Beaches

Wed 12/31

2:04 pm-8:38 pm

1 stop5h 34m

$384

RoanokePanama City

ROA - ECP

ROAECP

Roanoke

Sat 1/3

7:07 pm-11:58 pm

1 stop5h 51m

Panama City NW Florida Beaches

Sat 1/10

12:03 pm-8:31 pm

2 stops7h 28m

$388

RoanokePanama City

ROA - ECP

ROAECP

Roanoke

Mon 1/5

6:00 am-10:37 am

1 stop5h 37m

Panama City NW Florida Beaches

Mon 1/12

12:03 pm-8:31 pm

2 stops7h 28m

$391

RoanokePanama City

ROA - ECP

ROAECP

Roanoke

Sun 12/21

7:03 pm-10:44 pm

1 stop4h 41m

Panama City NW Florida Beaches

Sun 12/28

7:02 pm-12:07 am

1 stop4h 05m

$399

RoanokePanama City

ROA - ECP

ROAECP

Roanoke

Wed 12/24

6:00 am-10:37 am

1 stop5h 37m

Panama City NW Florida Beaches

Mon 12/29

4:09 pm-9:20 pm

1 stop4h 11m

$431

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Panama City from

How to get the cheapest flight ticket from Roanoke to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Roanoke is in February. Flight prices, which tend to average around $253, are often lower during this time because this is during the off-season. The month of August is another great option to travel to Panama City, Florida, with average flight prices from Roanoke averaging around $253.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Saturday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $338. On the other hand, Monday is the most expensive day to depart from Roanoke because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $519.

When to book flights from Roanoke to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to Panama City, Florida (ROA to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to Panama City, Florida

Fastest flight time

3h 17m

Direct flights

None
The fastest flight from Roanoke to Panama City, Florida takes 3h 17m
There are no direct flights from Roanoke to Panama City, Florida. There are no popular flight routes from Roanoke to Panama City, Florida.
Search flight deals

  • How far is Roanoke to Panama City NW Florida Beaches by plane?

    A flight from Roanoke to Panama City NW Florida Beaches will travel around 590.4 mi. Typically, this will take 3h 17m by plane in normal conditions.

  • When did momondo last update prices for flights from Roanoke Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Roanoke Airport to Panama City NW Florida Beaches Airport were last updated today.

  • How many operators does momondo search for flights from Roanoke Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Roanoke Airport to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Roanoke Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The travel and health documents required for your trip to Panama City NW Florida Beaches Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City NW Florida Beaches Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Roanoke to Panama City, Florida?

Best airlines flying from Roanoke to Panama City, Florida

Compare and see reviews for airlines that fly from Roanoke to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,045 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,011 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Roanoke to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Roanoke to Panama City with flexible booking policies on momondo?

Flights from Roanoke to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Roanoke to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Roanoke to Panama City.

I’m not ready to book a flight from Roanoke to Panama City right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama City from Roanoke. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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