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Cheap flights from Roanoke to Panama City from $274

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to Panama City departing on 11/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Roanoke to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
2:23 pm - 5:16 pmROA  Roanoke-ECP Panama City NW Florida Beaches
3h 53m1 stop Charlotte Douglas
American Airlines Logo
7:10 am - 2:43 pmECP  Panama City NW Florida Beaches-ROA Roanoke
6h 33m1 stop Charlotte Douglas
$319American Airlines
Wed, Sep 2 - Sun, Sep 6
Delta Logo
11:18 am - 3:06 pmROA  Roanoke-ECP Panama City NW Florida Beaches
4h 48m1 stop Atlanta Hartsfield-Jackson
Delta Logo
9:23 am - 2:40 pmECP  Panama City NW Florida Beaches-ROA Roanoke
4h 17m1 stop Atlanta Hartsfield-Jackson
$319Delta
Thu, Dec 17 - Fri, Dec 25
Delta Logo
6:54 pm - 11:24 pmROA  Roanoke-ECP Panama City NW Florida Beaches
5h 30m1 stop Atlanta Hartsfield-Jackson
Delta Logo
1:30 pm - 7:13 pmECP  Panama City NW Florida Beaches-ROA Roanoke
4h 43m1 stop Atlanta Hartsfield-Jackson
$319Delta
Fri, Dec 18 - Thu, Dec 24
Delta Logo
6:00 am - 8:20 amROA  Roanoke-ECP Panama City NW Florida Beaches
3h 20m1 stop Atlanta Hartsfield-Jackson
Delta Logo
9:23 am - 2:40 pmECP  Panama City NW Florida Beaches-ROA Roanoke
4h 17m1 stop Atlanta Hartsfield-Jackson
$319Delta
Wed, Dec 23 - Fri, Dec 25
United Airlines Logo
10:30 am - 9:36 pmROA  Roanoke-ECP Panama City NW Florida Beaches
12h 06m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
United Airlines Logo
2:15 pm - 9:01 pmECP  Panama City NW Florida Beaches-ROA Roanoke
5h 46m1 stop Chicago O'Hare Intl
$404United Airlines
Sat, Oct 31 - Sat, Nov 7
United Airlines Logo
6:40 am - 1:06 pmROA  Roanoke-ECP Panama City NW Florida Beaches
7h 26m1 stop Chicago O'Hare Intl
United Airlines Logo
11:41 am - 11:43 pmECP  Panama City NW Florida Beaches-ROA Roanoke
11h 02m2 stops Houston George Bush Intcntl Washington, D.C. Dulles Intl
$419United Airlines
Sat, Aug 29 - Wed, Sep 2
United Airlines Logo
6:15 am - 1:06 pmROA  Roanoke-ECP Panama City NW Florida Beaches
7h 51m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl
United Airlines Logo
1:47 pm - 8:59 pmECP  Panama City NW Florida Beaches-ROA Roanoke
6h 12m1 stop Chicago O'Hare Intl
$419United Airlines
Fri, Aug 28 - Wed, Sep 2
American Airlines Logo
1:00 pm - 6:27 pmROA  Roanoke-ECP Panama City NW Florida Beaches
6h 27m1 stop Charlotte Douglas
American Airlines Logo
6:57 pm - 11:48 pmECP  Panama City NW Florida Beaches-ROA Roanoke
3h 51m1 stop Charlotte Douglas
$424American Airlines
Sun, Aug 23 - Sun, Aug 30
American Airlines Logo
1:57 pm - 5:32 pmROA  Roanoke-ECP Panama City NW Florida Beaches
4h 35m1 stop Charlotte Douglas
American Airlines Logo
6:43 pm - 11:51 pmECP  Panama City NW Florida Beaches-ROA Roanoke
4h 08m1 stop Charlotte Douglas
$439American Airlines
Fri, Sep 11 - Sun, Sep 13
American Airlines Logo
7:16 am - 5:16 pmROA  Roanoke-ECP Panama City NW Florida Beaches
11h 00m2 stops Philadelphia Charlotte Douglas
American Airlines Logo
7:10 am - 12:25 pmECP  Panama City NW Florida Beaches-ROA Roanoke
4h 15m1 stop Charlotte Douglas
$488American Airlines
Wed, Sep 2 - Sun, Sep 6

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Delta flights from Roanoke to Panama City, Florida

Our best Delta deals on Roanoke to Panama City, Florida flight tickets
Delta
Dec 17
ROA11:18 amRoanoke
4h 48m
1 stop
ECP3:06 pmPanama City NW Florida Beaches
Dec 26
ECP7:05 pmPanama City NW Florida Beaches
4h 18m
1 stop
ROA12:23 amRoanoke
$319
Delta
Aug 24
ROA7:59 pmRoanoke
4h 31m
1 stop
ECP11:30 pmPanama City NW Florida Beaches
Aug 31
ECP6:00 amPanama City NW Florida Beaches
3h 37m
1 stop
ROA10:37 amRoanoke
$334
Delta
Aug 24
ROA6:00 amRoanoke
5h 42m
1 stop
ECP10:42 amPanama City NW Florida Beaches
Aug 29
ECP5:02 pmPanama City NW Florida Beaches
3h 36m
1 stop
ROA9:38 pmRoanoke
$349

United Airlines flights from Roanoke to Panama City, Florida

Our best United Airlines deals on Roanoke to Panama City, Florida flight tickets
United Airlines
Oct 31
ROA10:30 amRoanoke
12h 06m
2 stops
ECP9:36 pmPanama City NW Florida Beaches
Nov 7
ECP2:15 pmPanama City NW Florida Beaches
5h 46m
1 stop
ROA9:01 pmRoanoke
$404
United Airlines
Aug 24
ROA6:40 amRoanoke
10h 58m
2 stops
ECP4:38 pmPanama City NW Florida Beaches
Sep 1
ECP1:47 pmPanama City NW Florida Beaches
6h 12m
1 stop
ROA8:59 pmRoanoke
$419
United Airlines
Aug 24
ROA6:40 amRoanoke
10h 58m
2 stops
ECP4:38 pmPanama City NW Florida Beaches
Sep 1
ECP1:47 pmPanama City NW Florida Beaches
8h 57m
2 stops
ROA11:44 pmRoanoke
$425

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 13, 2026.
Use the filters below to find and compare flights from Roanoke to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RoanokePanama City

ROA Roanoke - ECP Panama City NW Florida Beaches

ROAECP

Roanoke

Wed 9/2

2:23 pm-5:16 pm

1 stop3h 53m

Panama City NW Florida Beaches

Sun 9/6

7:10 am-2:43 pm

1 stop6h 33m

$319

RoanokePanama City

ROA Roanoke - ECP Panama City NW Florida Beaches

ROAECP

Roanoke

Thu 12/17

11:18 am-3:06 pm

1 stop4h 48m

Panama City NW Florida Beaches

Fri 12/25

9:23 am-2:40 pm

1 stop4h 17m

$319

RoanokePanama City

ROA Roanoke - ECP Panama City NW Florida Beaches

ROAECP

Roanoke

Fri 12/18

6:54 pm-11:24 pm

1 stop5h 30m

Panama City NW Florida Beaches

Thu 12/24

1:30 pm-7:13 pm

1 stop4h 43m

$319
Quickest round-trip

RoanokePanama City

ROA Roanoke - ECP Panama City NW Florida Beaches

ROAECP

Roanoke

Wed 12/23

6:00 am-8:20 am

1 stop3h 20m

Panama City NW Florida Beaches

Fri 12/25

9:23 am-2:40 pm

1 stop4h 17m

$319

RoanokePanama City

ROA Roanoke - ECP Panama City NW Florida Beaches

ROAECP

Roanoke

Sat 10/31

10:30 am-9:36 pm

2 stops12h 06m

Panama City NW Florida Beaches

Sat 11/7

2:15 pm-9:01 pm

1 stop5h 46m

$404

RoanokePanama City

ROA Roanoke - ECP Panama City NW Florida Beaches

ROAECP

Roanoke

Sat 8/29

6:40 am-1:06 pm

1 stop7h 26m

Panama City NW Florida Beaches

Wed 9/2

11:41 am-11:43 pm

2 stops11h 02m

$419

RoanokePanama City

ROA Roanoke - ECP Panama City NW Florida Beaches

ROAECP

Roanoke

Fri 8/28

6:15 am-1:06 pm

2 stops7h 51m

Panama City NW Florida Beaches

Wed 9/2

1:47 pm-8:59 pm

1 stop6h 12m

$419

RoanokePanama City

ROA Roanoke - ECP Panama City NW Florida Beaches

ROAECP

Roanoke

Sun 8/23

1:00 pm-6:27 pm

1 stop6h 27m

Panama City NW Florida Beaches

Sun 8/30

6:57 pm-11:48 pm

1 stop3h 51m

$424

RoanokePanama City

ROA Roanoke - ECP Panama City NW Florida Beaches

ROAECP

Roanoke

Fri 9/11

1:57 pm-5:32 pm

1 stop4h 35m

Panama City NW Florida Beaches

Sun 9/13

6:43 pm-11:51 pm

1 stop4h 08m

$439

RoanokePanama City

ROA Roanoke - ECP Panama City NW Florida Beaches

ROAECP

Roanoke

Wed 9/2

7:16 am-5:16 pm

2 stops11h 00m

Panama City NW Florida Beaches

Sun 9/6

7:10 am-12:25 pm

1 stop4h 15m

$488

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Roanoke to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Roanoke is in January. Flight prices, which tend to average around $318, are often lower during this time because this is during the off-season. The month of June is another great option to travel to Panama City, Florida, with average flight prices from Roanoke averaging around $328.

When to book flights from Roanoke to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to Panama City, Florida (ROA to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to Panama City, Florida

Fastest flight time

3h 14m

Direct flights

None
The fastest flight from Roanoke to Panama City, Florida takes 3h 14m
There are no direct flights from Roanoke to Panama City, Florida. There are no popular flight routes from Roanoke to Panama City, Florida.
Search flight deals

Frequently asked questions about flying from Roanoke to Panama City, Florida

  • How far is Roanoke to Panama City NW Florida Beaches by plane?

    A flight from Roanoke to Panama City NW Florida Beaches will travel around 590.4 mi. Typically, this will take 3h 14m by plane in normal conditions.

  • When did momondo last update prices for flights from Roanoke Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Roanoke Airport to Panama City NW Florida Beaches Airport were last updated today.

  • How many operators does momondo search for flights from Roanoke Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Roanoke Airport to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Roanoke Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The travel and health documents required for your trip to Panama City NW Florida Beaches Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Panama City NW Florida Beaches Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Roanoke to Panama City, Florida?

Best airlines flying from Roanoke to Panama City, Florida

Compare and see reviews for airlines that fly from Roanoke to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,911 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.8
8,505 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Roanoke to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Roanoke to Panama City with flexible booking policies on momondo?

Flights from Roanoke to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Roanoke to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Roanoke to Panama City.

I’m not ready to book a flight from Roanoke to Panama City right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama City from Roanoke. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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