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Cheap flights from Roanoke to Knoxville from $153

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to Knoxville departing on 5/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Roanoke to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:10 pm - 8:10 pm
ROA
-
TYS
5h 00m
1 stop
American Airlines Logo
7:59 pm - 11:47 pm
TYS
-
ROA
3h 48m
1 stop
$279American Airlines
Wed, May 27 - Sat, May 30
Delta Logo
7:30 pm - 11:56 pm
ROA
-
TYS
4h 26m
1 stop
Delta Logo
5:40 am - 10:30 am
TYS
-
ROA
4h 50m
1 stop
$294Delta
Wed, May 20 - Wed, May 27
Delta Logo
7:50 pm - 11:47 pm
ROA
-
TYS
3h 57m
1 stop
Delta Logo
4:00 pm - 7:16 pm
TYS
-
ROA
3h 16m
1 stop
$304Delta
Fri, Oct 2 - Mon, Oct 5
American Airlines Logo
3:10 pm - 8:10 pm
ROA
-
TYS
5h 00m
1 stop
American Airlines Logo
7:59 pm - 11:47 pm
TYS
-
ROA
3h 48m
1 stop
$309American Airlines
Sat, May 23 - Wed, May 27
Delta Logo
6:00 am - 9:34 am
ROA
-
TYS
3h 34m
1 stop
Delta Logo
7:33 pm - 12:34 am
TYS
-
ROA
5h 01m
1 stop
$319Delta
Wed, May 20 - Wed, May 27
United Airlines Logo
10:30 am - 2:37 pm
ROA
-
TYS
4h 07m
1 stop
United Airlines Logo
5:45 am - 9:44 am
TYS
-
ROA
3h 59m
1 stop
$349United Airlines
Sat, Aug 29 - Wed, Sep 2
United Airlines Logo
10:30 am - 8:48 pm
ROA
-
TYS
10h 18m
2 stops
United Airlines Logo
10:00 am - 2:18 pm
TYS
-
ROA
4h 18m
1 stop
$354United Airlines
Sat, Aug 29 - Wed, Sep 2
United Airlines Logo
10:30 am - 8:48 pm
ROA
-
TYS
10h 18m
2 stops
United Airlines Logo
6:30 am - 7:07 pm
TYS
-
ROA
12h 37m
2 stops
$359United Airlines
Sat, Aug 29 - Wed, Sep 2
United Airlines Logo
6:15 am - 10:42 am
ROA
-
TYS
4h 27m
1 stop
United Airlines Logo
5:45 am - 9:42 am
TYS
-
ROA
3h 57m
1 stop
$369United Airlines
Wed, May 27 - Sat, May 30
Allegiant Air Logo
3:03 pm - 10:16 pm
ROA
-
TYS
7h 13m
1 stop
Allegiant Air Logo
7:01 pm - 3:13 pm
TYS
-
ROA
20h 12m
1 stop
$379Allegiant Air
Sun, Jun 21 - Sun, Jun 28

United Airlines flights from Roanoke to Knoxville

Our best United Airlines deals on Roanoke to Knoxville flight tickets
United Airlines
Aug 29
ROA10:30 amRoanoke
4h 07m
1 stop
TYS2:37 pmKnoxville McGhee Tyson
Sep 2
TYS5:45 amKnoxville McGhee Tyson
3h 59m
1 stop
ROA9:44 amRoanoke
$349
United Airlines
Aug 29
ROA10:30 amRoanoke
10h 18m
2 stops
TYS8:48 pmKnoxville McGhee Tyson
Sep 2
TYS10:00 amKnoxville McGhee Tyson
4h 18m
1 stop
ROA2:18 pmRoanoke
$354
United Airlines
Aug 29
ROA10:30 amRoanoke
10h 18m
2 stops
TYS8:48 pmKnoxville McGhee Tyson
Sep 2
TYS6:30 amKnoxville McGhee Tyson
12h 37m
2 stops
ROA7:07 pmRoanoke
$359

Delta flights from Roanoke to Knoxville

Our best Delta deals on Roanoke to Knoxville flight tickets
Delta
May 20
ROA7:30 pmRoanoke
4h 26m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
May 27
TYS5:40 amKnoxville McGhee Tyson
4h 50m
1 stop
ROA10:30 amRoanoke
$294
Delta
Oct 2
ROA7:50 pmRoanoke
3h 57m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
Oct 5
TYS4:00 pmKnoxville McGhee Tyson
3h 16m
1 stop
ROA7:16 pmRoanoke
$304
Delta
May 20
ROA6:00 amRoanoke
3h 34m
1 stop
TYS9:34 amKnoxville McGhee Tyson
May 27
TYS7:33 pmKnoxville McGhee Tyson
5h 01m
1 stop
ROA12:34 amRoanoke
$319

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 10, 2026.
Use the filters below to find and compare flights from Roanoke to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RoanokeKnoxville

ROA - TYS

ROATYS

Roanoke

Wed 5/27

3:10 pm-8:10 pm

1 stop5h 00m

Knoxville McGhee Tyson

Sat 5/30

7:59 pm-11:47 pm

1 stop3h 48m

$279

RoanokeKnoxville

ROA - TYS

ROATYS

Roanoke

Wed 5/20

7:30 pm-11:56 pm

1 stop4h 26m

Knoxville McGhee Tyson

Wed 5/27

5:40 am-10:30 am

1 stop4h 50m

$294
Quickest round-trip

RoanokeKnoxville

ROA - TYS

ROATYS

Roanoke

Fri 10/2

7:50 pm-11:47 pm

1 stop3h 57m

Knoxville McGhee Tyson

Mon 10/5

4:00 pm-7:16 pm

1 stop3h 16m

$304

RoanokeKnoxville

ROA - TYS

ROATYS

Roanoke

Sat 5/23

3:10 pm-8:10 pm

1 stop5h 00m

Knoxville McGhee Tyson

Wed 5/27

7:59 pm-11:47 pm

1 stop3h 48m

$309

RoanokeKnoxville

ROA - TYS

ROATYS

Roanoke

Wed 5/20

6:00 am-9:34 am

1 stop3h 34m

Knoxville McGhee Tyson

Wed 5/27

7:33 pm-12:34 am

1 stop5h 01m

$319

RoanokeKnoxville

ROA - TYS

ROATYS

Roanoke

Sat 8/29

10:30 am-2:37 pm

1 stop4h 07m

Knoxville McGhee Tyson

Wed 9/2

5:45 am-9:44 am

1 stop3h 59m

$349

RoanokeKnoxville

ROA - TYS

ROATYS

Roanoke

Sat 8/29

10:30 am-8:48 pm

2 stops10h 18m

Knoxville McGhee Tyson

Wed 9/2

10:00 am-2:18 pm

1 stop4h 18m

$354

RoanokeKnoxville

ROA - TYS

ROATYS

Roanoke

Sat 8/29

10:30 am-8:48 pm

2 stops10h 18m

Knoxville McGhee Tyson

Wed 9/2

6:30 am-7:07 pm

2 stops12h 37m

$359

RoanokeKnoxville

ROA - TYS

ROATYS

Roanoke

Wed 5/27

6:15 am-10:42 am

1 stop4h 27m

Knoxville McGhee Tyson

Sat 5/30

5:45 am-9:42 am

1 stop3h 57m

$369

RoanokeKnoxville

ROA - TYS

ROATYS

Roanoke

Sun 6/21

3:03 pm-10:16 pm

1 stop7h 13m

Knoxville McGhee Tyson

Sun 6/28

7:01 pm-3:13 pm

1 stop20h 12m

$379

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Roanoke to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Roanoke to Knoxville McGhee Tyson?

Allegiant Air, Delta, and United Airlines are the most popular carriers operating from Roanoke to Knoxville McGhee Tyson

When to book flights from Roanoke to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Roanoke to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Roanoke to Knoxville (ROA to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to Knoxville

Fastest flight time

3h 56m

Direct flights

None
The fastest flight from Roanoke to Knoxville takes 3h 56m
There are no direct flights from Roanoke to Knoxville. There are no popular flight routes from Roanoke to Knoxville.
Search flight deals

Frequently asked questions about flying from Roanoke to Knoxville

  • How far is Roanoke to Knoxville McGhee Tyson by plane?

    The distance between Roanoke and Knoxville McGhee Tyson is about 238.3 mi. In terms of flight time, this usually takes a little over 3h 56m.

  • When did momondo last update prices for flights from Roanoke Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Roanoke Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Roanoke Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Roanoke Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Alcoa
Corbin
Crossville
Maryville
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Roanoke to Knoxville for you.

Can I find flights from Roanoke to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Roanoke with this policy.

How can momondo help me find flights from Roanoke to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Roanoke.

I’m not ready to book a flight from Roanoke to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Roanoke and alert you when they change.

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