What airlines fly to South America?

American Airlines, LATAM Airlines and Delta are the top three most popular airlines that fly to South America from Raleigh according to our data. American Airlines is the first choice among our users, with 27% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 7 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Raleigh-Durham to South America?

Copa Airlines, American Airlines, and United Airlines are the most popular carriers operating from Raleigh-Durham to South America

When did momondo last update prices for flights from Raleigh-Durham Airport to South America?

Prices for flights from Raleigh-Durham Airport to South America refresh daily.

How many operators does momondo search for flights from Raleigh-Durham Airport to South America?

The number of operators available for flights from Raleigh-Durham Airport to South America is 7 as of November 2026.

How old do you have to be to fly from Raleigh-Durham Airport to South America?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Raleigh-Durham Airport to South America.

What documentation or ID do you need to fly to South America?

The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$143 Cheap Flights from Raleigh to South America in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Raleigh to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

3:12 pm - 8:35 amRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

17h 23m1 stop Panama City Tocumen Intl

7:05 pm - 1:25 pmCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

18h 20m1 stop Panama City Tocumen Intl

$288Copa Airlines

Sun, Jan 31 - Thu, Feb 4

3:17 pm - 11:00 amRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

19h 43m1 stop Panama City Tocumen Intl

3:05 pm - 1:25 pmCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

22h 20m1 stop Panama City Tocumen Intl

$308Copa Airlines

Mon, Feb 1 - Sat, Feb 6

10:38 am - 12:00 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

25h 22m1 stop Orlando

1:10 pm - 9:43 amMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

20h 33m1 stop Orlando

$359Frontier

Tue, Feb 2 - Sat, Feb 6

7:41 am - 2:09 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

6h 28m1 stop Atlanta Hartsfield-Jackson

3:34 pm - 10:06 amCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

18h 32m1 stop Atlanta Hartsfield-Jackson

$369Delta

Sat, Nov 28 - Sat, Dec 5

12:35 pm - 12:00 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

23h 25m2 stops Atlanta Hartsfield-Jackson Orlando

1:10 pm - 9:43 amMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

20h 33m1 stop Orlando

$374Frontier

Tue, Feb 2 - Sat, Feb 6

7:03 am - 3:38 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

8h 35m1 stop Miami

4:38 pm - 12:30 amCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

7h 52m1 stop Miami

$381American Airlines

Sun, Jan 31 - Thu, Feb 4

6:15 am - 2:50 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

8h 35m1 stop Houston George Bush Intcntl

4:00 pm - 11:44 pmCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

7h 44m1 stop Washington, D.C. Dulles Intl

$381United Airlines

Sun, Jan 24 - Thu, Jan 28

7:41 am - 2:09 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

6h 28m1 stop Atlanta Hartsfield-Jackson

4:00 am - 7:55 pmCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

15h 55m2 stops Bogotá El Dorado Miami

$384Delta

Sat, Nov 28 - Wed, Dec 2

5:38 pm - 1:36 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

19h 58m2 stops Charlotte Douglas Miami

4:37 pm - 10:07 amCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

17h 30m2 stops Miami Washington, D.C. Reagan-National

$385American Airlines

Sat, Dec 5 - Sun, Dec 13

6:15 am - 10:10 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

15h 55m1 stop Houston George Bush Intcntl

10:40 am - 10:05 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

11h 25m1 stop Houston George Bush Intcntl

$433United Airlines

Wed, Feb 3 - Mon, Feb 8

Cheap last minute flights

Enter your travel dates to find the best prices.

3:17 pm - 2:45 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

23h 28m1 stop Panama City Tocumen Intl

6:25 am - 1:27 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

7h 02m1 stop Panama City Tocumen Intl

$419Copa Airlines

Fri, Nov 13 - Sun, Nov 15

3:17 pm - 2:45 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

23h 28m1 stop Panama City Tocumen Intl

6:25 am - 1:27 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

7h 02m1 stop Panama City Tocumen Intl

$439Copa Airlines

Fri, Nov 13 - Sun, Nov 15

1:00 pm - 10:10 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

9h 10m1 stop Houston George Bush Intcntl

10:40 am - 10:07 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

11h 27m1 stop Houston George Bush Intcntl

$453United Airlines

Tue, Nov 10 - Mon, Dec 7

5:24 pm - 10:10 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

28h 46m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

10:40 am - 9:59 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

11h 19m1 stop Houston George Bush Intcntl

$457United Airlines

Fri, Nov 13 - Wed, Nov 18

7:41 am - 7:30 pmRDU Raleigh-Durham-BOG Bogotá El Dorado

11h 49m1 stop Atlanta Hartsfield-Jackson

8:35 am - 12:24 amBOG Bogotá El Dorado-RDU Raleigh-Durham

15h 49m2 stops Miami Atlanta Hartsfield-Jackson

$521Delta

Fri, Nov 13 - Mon, Nov 16

7:08 pm - 7:40 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

24h 32m2 stops Miami Santo Domingo Las Americas

1:10 pm - 11:46 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

10h 36m1 stop Orlando

$530Multiple Airlines

Thu, Nov 12 - Fri, Dec 11

7:08 pm - 7:40 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

24h 32m2 stops Miami Santo Domingo Las Americas

1:10 pm - 8:58 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

7h 48m1 stop Orlando

$530Multiple Airlines

Thu, Nov 12 - Thu, Dec 10

3:39 pm - 8:07 amRDU Raleigh-Durham-GYE Guayaquil Jose Joaquin de Olmedo

16h 28m1 stop New York John F Kennedy Intl

5:00 pm - 10:51 amGYE Guayaquil Jose Joaquin de Olmedo-RDU Raleigh-Durham

17h 51m1 stop New York John F Kennedy Intl

$554LATAM Airlines

Mon, Nov 9 - Mon, Nov 16

7:51 pm - 8:07 amRDU Raleigh-Durham-GYE Guayaquil Jose Joaquin de Olmedo

12h 16m1 stop New York John F Kennedy Intl

5:00 pm - 11:50 amGYE Guayaquil Jose Joaquin de Olmedo-RDU Raleigh-Durham

18h 50m2 stops New York John F Kennedy Intl Atlanta Hartsfield-Jackson

$612Delta

Mon, Nov 9 - Mon, Nov 16

6:05 pm - 6:05 amRDU Raleigh-Durham-LIM Lima J Chavez Intl

12h 00m2 stops Atlanta Hartsfield-Jackson Miami

8:20 am - 7:50 pmLIM Lima J Chavez Intl-RDU Raleigh-Durham

11h 30m1 stop Miami

$632LATAM Airlines

Thu, Nov 12 - Thu, Nov 19

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Copa Airlines flights from Raleigh to South America

Our best Copa Airlines deals on Raleigh to South America flight tickets

Copa Airlines

Feb 1

RDU3:17 pmRaleigh-Durham

19h 43m

1 stop

CTG11:00 amCartagena Rafael Nunez

Feb 6

CTG3:05 pmCartagena Rafael Nunez

22h 20m

1 stop

RDU1:25 pmRaleigh-Durham

$308

Copa Airlines

Feb 8

RDU3:17 pmRaleigh-Durham

22h 58m

1 stop

MDE2:15 pmMedellín Jose Maria Cordova Intl

Mar 2

MDE4:30 pmMedellín Jose Maria Cordova Intl

21h 21m

1 stop

RDU1:51 pmRaleigh-Durham

$400

Copa Airlines

Jan 17

RDU3:12 pmRaleigh-Durham

18h 13m

1 stop

BOG9:25 amBogotá El Dorado

Jan 23

BOG4:45 amBogotá El Dorado

8h 31m

1 stop

RDU1:16 pmRaleigh-Durham

$414

Delta flights from Raleigh to South America

Our best Delta deals on Raleigh to South America flight tickets

Delta

Nov 28

RDU7:41 amRaleigh-Durham

6h 28m

1 stop

CTG2:09 pmCartagena Rafael Nunez

Dec 5

CTG3:34 pmCartagena Rafael Nunez

18h 32m

1 stop

RDU10:06 amRaleigh-Durham

$369

Delta

Nov 28

RDU7:41 amRaleigh-Durham

6h 28m

1 stop

CTG2:09 pmCartagena Rafael Nunez

Dec 2

CTG4:00 amCartagena Rafael Nunez

15h 55m

2 stops

RDU7:55 pmRaleigh-Durham

$384

Delta

Nov 27

RDU12:56 pmRaleigh-Durham

25h 13m

1 stop

CTG2:09 pmCartagena Rafael Nunez

Dec 2

CTG4:00 amCartagena Rafael Nunez

15h 55m

2 stops

RDU7:55 pmRaleigh-Durham

$391

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Sun 1/31

3:12 pm-8:35 am

1 stop17h 23m

Cartagena Rafael Nunez

Thu 2/4

7:05 pm-1:25 pm

1 stop18h 20m

$288

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Mon 2/1

3:17 pm-11:00 am

1 stop19h 43m

Cartagena Rafael Nunez

Sat 2/6

3:05 pm-1:25 pm

1 stop22h 20m

$308

RaleighMedellín

RDU Raleigh-Durham - MDE Medellín Jose Maria Cordova Intl

RDUMDE

Raleigh-Durham

Tue 2/2

10:38 am-12:00 pm

1 stop25h 22m

Medellín Jose Maria Cordova Intl

Sat 2/6

1:10 pm-9:43 am

1 stop20h 33m

$359

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Sat 11/28

7:41 am-2:09 pm

1 stop6h 28m

Cartagena Rafael Nunez

Sat 12/5

3:34 pm-10:06 am

1 stop18h 32m

$369

RaleighMedellín

RDU Raleigh-Durham - MDE Medellín Jose Maria Cordova Intl

RDUMDE

Raleigh-Durham

Tue 2/2

12:35 pm-12:00 pm

2 stops23h 25m

Medellín Jose Maria Cordova Intl

Sat 2/6

1:10 pm-9:43 am

1 stop20h 33m

$374

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Sun 1/31

7:03 am-3:38 pm

1 stop8h 35m

Cartagena Rafael Nunez

Thu 2/4

4:38 pm-12:30 am

1 stop7h 52m

$381

Quickest round-trip

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Sun 1/24

6:15 am-2:50 pm

1 stop8h 35m

Cartagena Rafael Nunez

Thu 1/28

4:00 pm-11:44 pm

1 stop7h 44m

$381

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Sat 11/28

7:41 am-2:09 pm

1 stop6h 28m

Cartagena Rafael Nunez

Wed 12/2

4:00 am-7:55 pm

2 stops15h 55m

$384

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Sat 12/5

5:38 pm-1:36 pm

2 stops19h 58m

Cartagena Rafael Nunez

Sun 12/13

4:37 pm-10:07 am

2 stops17h 30m

$385

RaleighMedellín

RDU Raleigh-Durham - MDE Medellín Jose Maria Cordova Intl

RDUMDE

Raleigh-Durham

Wed 2/3

6:15 am-10:10 pm

1 stop15h 55m

Medellín Jose Maria Cordova Intl

Mon 2/8

10:40 am-10:05 pm

1 stop11h 25m

$433

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Raleigh to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from Raleigh to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $524. If you aren’t able to travel during the month of February, then book flights to South America from Raleigh during April instead. Flights to South America in April, while not as cheap as those in February, still average around $560.

How far in advance should I book a flight from Raleigh to South America?

You are more likely to see cheaper flights to South America from Raleigh when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $670 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Raleigh for as low as $606 on momondo.

Can stopping save me money on Raleigh to South America flights?

You could potentially save up to 29% on your flight if you consider stops on a Raleigh to South America flight.

Cheap Raleigh to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Raleigh to South America

Best Price Found	$143
Fastest flight time	5h 55m
Direct flights	None

The best one-way flight to South America from Raleigh in the past 72 hours is $143. The best round-trip flight deal from Raleigh to South America found on momondo in the last 72 hours is $288.

The fastest flight from Raleigh to South America takes 5h 55m

There are no direct flights from Raleigh to South America. There are no popular flight routes from Raleigh to South America.

Search flight deals

Frequently asked questions about flying from Raleigh to South America

When did momondo last update prices for flights from Raleigh-Durham Airport to South America?
Prices for flights from Raleigh-Durham Airport to South America refresh daily.
How many operators does momondo search for flights from Raleigh-Durham Airport to South America?
The number of operators available for flights from Raleigh-Durham Airport to South America is 7 as of November 2026.
How old do you have to be to fly from Raleigh-Durham Airport to South America?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Raleigh-Durham Airport to South America.
What documentation or ID do you need to fly to South America?
The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Raleigh to South America

Compare and see reviews for airlines that fly from Raleigh to South America with momondo

Airline	Rating	Free Cancellation	Price
JetBlue	PriceFrom $172	Free Cancellation	Rating 7.1 3,064 reviews	Search JetBlue flights
Copa Airlines	PriceFrom $216	Free Cancellation	Rating 7.6 1,555 reviews	Search Copa Airlines flights
American Airlines	PriceFrom $278	Free Cancellation	Rating 7.0 12,228 reviews	Search American Airlines flights
United Airlines	PriceFrom $304	Free Cancellation	Rating 7.3 10,471 reviews	Search United Airlines flights
Delta	PriceFrom $343	Free Cancellation	Rating 7.8 8,699 reviews	Search Delta flights
LATAM Airlines	PriceFrom $345	Free Cancellation	Rating 7.4 1,972 reviews	Search LATAM Airlines flights
GOL	PriceFrom $623	Free Cancellation	Rating 7.3 1,333 reviews	Search GOL flights

Why use momondo?

Why should I use momondo to find a flight deal from Raleigh to South America?

Finding the right flight to South America from Raleigh is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South America quick and easy, saving you time and money.

Can I find flights from Raleigh to South America with flexible booking policies on momondo?

Flights from Raleigh to South America with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Raleigh to South America?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Raleigh to South America.

I’m not ready to book a flight from Raleigh to South America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South America from Raleigh. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.