What is the cheapest airline that flies from Raleigh-Durham to South America?

JetBlue, United Airlines, and American Airlines are the most popular carriers operating from Raleigh-Durham to South America

What airlines fly to South America?

American Airlines, LATAM Airlines and Copa Airlines are the top three most popular airlines that fly to South America from Raleigh according to our data. American Airlines is the first choice among our users, with 28% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 8 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Raleigh-Durham Airport to South America?

Prices for flights from Raleigh-Durham Airport to South America refresh daily.

How many operators does momondo search for flights from Raleigh-Durham Airport to South America?

The number of operators available for flights from Raleigh-Durham Airport to South America is 8 as of September 2025.

How old do you have to be to fly from Raleigh-Durham Airport to South America?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Raleigh-Durham Airport to South America.

What documentation or ID do you need to fly to South America?

The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$105 Cheap Flights from Raleigh to South America in 2025/26

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Find the cheapest flights from Raleigh to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

4:19 pm - 8:17 amRDU-MDE

16h 58m1 stop

6:24 am - 2:27 pmMDE-RDU

7h 03m1 stop

$253Copa Airlines

Find Deal

Wed, Oct 22 - Mon, Oct 27

7:15 am - 2:05 pmRDU-MDE

7h 50m1 stop

1:10 pm - 10:06 pmMDE-RDU

7h 56m1 stop

$263JetBlue

Find Deal

Tue, Oct 21 - Wed, Oct 29

8:33 am - 11:39 pmRDU-MDE

15h 06m1 stop

1:30 am - 6:10 pmMDE-RDU

16h 40m1 stop

$283American Airlines

Find Deal

Tue, Nov 4 - Wed, Nov 12

5:24 am - 8:15 pmRDU-MDE

15h 51m2 stops

1:35 pm - 11:56 pmMDE-RDU

9h 21m1 stop

$287American Airlines

Find Deal

Sat, Oct 18 - Tue, Oct 21

6:00 am - 9:10 pmRDU-MDE

16h 10m1 stop

9:45 am - 11:41 pmMDE-RDU

12h 56m2 stops

$307United Airlines

Find Deal

Tue, Oct 21 - Wed, Oct 29

6:00 am - 10:05 pmRDU-MDE

16h 05m2 stops

1:15 am - 12:44 pmMDE-RDU

11h 29m1 stop

$309United Airlines

Find Deal

Tue, Nov 18 - Mon, Dec 8

8:10 am - 7:58 pmRDU-BOG

12h 48m1 stop

1:35 am - 8:25 pmBOG-RDU

17h 50m1 stop

$333LATAM Airlines

Find Deal

Wed, Oct 8 - Sun, Oct 19

8:10 am - 11:00 pmRDU-CTG

15h 50m2 stops

2:30 pm - 12:17 amCTG-RDU

8h 47m1 stop

$335Delta

Find Deal

Tue, Oct 7 - Sat, Oct 18

7:22 am - 7:15 pmRDU-BOG

12h 53m1 stop

10:55 am - 8:25 pmBOG-RDU

8h 30m1 stop

$336LATAM Airlines

Find Deal

Fri, Oct 24 - Tue, Oct 28

6:00 am - 2:14 pmRDU-CTG

8h 14m1 stop

3:29 pm - 12:20 amCTG-RDU

8h 51m1 stop

$336Delta

Find Deal

Sat, Nov 15 - Sat, Nov 22

American Airlines flights from Raleigh to South America

Our best American Airlines deals on Raleigh to South America flight tickets

American Airlines

Nov 4

RDU8:33 amRaleigh-Durham

15h 06m

1 stop

MDE11:39 pmMedellín Jose Maria Cordova Intl

Nov 12

MDE1:30 amMedellín Jose Maria Cordova Intl

16h 40m

1 stop

RDU6:10 pmRaleigh-Durham

$283

Find similar

American Airlines

Oct 18

RDU5:24 amRaleigh-Durham

15h 51m

2 stops

MDE8:15 pmMedellín Jose Maria Cordova Intl

Oct 21

MDE1:35 pmMedellín Jose Maria Cordova Intl

9h 21m

1 stop

RDU11:56 pmRaleigh-Durham

$287

Find similar

American Airlines

Oct 30

RDU6:32 pmRaleigh-Durham

19h 03m

1 stop

MDE12:35 pmMedellín Jose Maria Cordova Intl

Nov 12

MDE7:00 amMedellín Jose Maria Cordova Intl

11h 10m

1 stop

RDU6:10 pmRaleigh-Durham

$290

Find similar

Copa Airlines flights from Raleigh to South America

Our best Copa Airlines deals on Raleigh to South America flight tickets

Copa Airlines

Oct 22

RDU4:19 pmRaleigh-Durham

16h 58m

1 stop

MDE8:17 amMedellín Jose Maria Cordova Intl

Oct 27

MDE6:24 amMedellín Jose Maria Cordova Intl

7h 03m

1 stop

RDU2:27 pmRaleigh-Durham

$253

Find similar

Copa Airlines

Sep 24

RDU4:21 pmRaleigh-Durham

16h 56m

1 stop

MDE8:17 amMedellín Jose Maria Cordova Intl

Oct 1

MDE6:37 amMedellín Jose Maria Cordova Intl

6h 50m

1 stop

RDU2:27 pmRaleigh-Durham

$285

Find similar

Copa Airlines

Oct 24

RDU4:19 pmRaleigh-Durham

8h 47m

1 stop

BOG12:06 amBogotá El Dorado

Oct 29

BOG6:10 amBogotá El Dorado

7h 17m

1 stop

RDU2:27 pmRaleigh-Durham

$291

Find similar

Fly from

Fly to

Route

Depart

Return

Price

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Wed 10/22

4:19 pm-8:17 am

1 stop16h 58m

Medellín Jose Maria Cordova Intl

Mon 10/27

6:24 am-2:27 pm

1 stop7h 03m

$253

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Tue 10/21

7:15 am-2:05 pm

1 stop7h 50m

Medellín Jose Maria Cordova Intl

Wed 10/29

1:10 pm-10:06 pm

1 stop7h 56m

$263

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Tue 11/4

8:33 am-11:39 pm

1 stop15h 06m

Medellín Jose Maria Cordova Intl

Wed 11/12

1:30 am-6:10 pm

1 stop16h 40m

$283

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Sat 10/18

5:24 am-8:15 pm

2 stops15h 51m

Medellín Jose Maria Cordova Intl

Tue 10/21

1:35 pm-11:56 pm

1 stop9h 21m

$287

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Tue 10/21

6:00 am-9:10 pm

1 stop16h 10m

Medellín Jose Maria Cordova Intl

Wed 10/29

9:45 am-11:41 pm

2 stops12h 56m

$307

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Tue 11/18

6:00 am-10:05 pm

2 stops16h 05m

Medellín Jose Maria Cordova Intl

Mon 12/8

1:15 am-12:44 pm

1 stop11h 29m

$309

RaleighBogotá

RDU - BOG

RDUBOG

Raleigh-Durham

Wed 10/8

8:10 am-7:58 pm

1 stop12h 48m

Bogotá El Dorado

Sun 10/19

1:35 am-8:25 pm

1 stop17h 50m

$333

RaleighCartagena

RDU - CTG

RDUCTG

Raleigh-Durham

Tue 10/7

8:10 am-11:00 pm

2 stops15h 50m

Cartagena Rafael Nunez

Sat 10/18

2:30 pm-12:17 am

1 stop8h 47m

$335

RaleighBogotá

RDU - BOG

RDUBOG

Raleigh-Durham

Fri 10/24

7:22 am-7:15 pm

1 stop12h 53m

Bogotá El Dorado

Tue 10/28

10:55 am-8:25 pm

1 stop8h 30m

$336

RaleighCartagena

RDU - CTG

RDUCTG

Raleigh-Durham

Sat 11/15

6:00 am-2:14 pm

1 stop8h 14m

Cartagena Rafael Nunez

Sat 11/22

3:29 pm-12:20 am

1 stop8h 51m

$336

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Raleigh to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, September is the cheapest month to fly from Raleigh to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $472. If you aren’t able to travel during the month of September, then book flights to South America from Raleigh during November instead. Flights to South America in November, while not as cheap as those in September, still average around $501.

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Raleigh to South America is on a Monday when prices can be found for as low as $594. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Raleigh to South America for around $711.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest Raleigh to South America flights are usually those with departure times in the afternoon. Our users have found flights to South America in the afternoon for as low as $521. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $742 on average. Flights to South America from Raleigh at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from Raleigh when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $585 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Raleigh for as low as $536 on momondo.

Can stopping save me money on Raleigh to South America flights?

You could potentially save up to 56% on your flight if you consider stops on a Raleigh to South America flight.

Cheap Raleigh to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Raleigh to South America

Direct flights	None

There are no direct flights from Raleigh to South America. There are no popular flight routes from Raleigh to South America.

Search flight deals

When did momondo last update prices for flights from Raleigh-Durham Airport to South America?
Prices for flights from Raleigh-Durham Airport to South America refresh daily.
How many operators does momondo search for flights from Raleigh-Durham Airport to South America?
The number of operators available for flights from Raleigh-Durham Airport to South America is 8 as of September 2025.
How old do you have to be to fly from Raleigh-Durham Airport to South America?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Raleigh-Durham Airport to South America.
What documentation or ID do you need to fly to South America?
The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Raleigh to South America

Compare and see reviews for airlines that fly from Raleigh to South America with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $189	Free Cancellation	Rating 7.9 7,961 reviews	Search Delta flights
Spirit Airlines	PriceFrom $222	Free Cancellation	Rating 6.3 8,023 reviews	Search Spirit Airlines flights
LATAM Airlines	PriceFrom $225	Free Cancellation	Rating 7.5 1,849 reviews	Search LATAM Airlines flights
Copa Airlines	PriceFrom $249	Free Cancellation	Rating 7.6 1,533 reviews	Search Copa Airlines flights
American Airlines	PriceFrom $289	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights
United Airlines	PriceFrom $311	Free Cancellation	Rating 7.4 8,926 reviews	Search United Airlines flights
JetBlue	PriceFrom $374	Free Cancellation	Rating 7.2 2,914 reviews	Search JetBlue flights
GOL	PriceFrom $481	Free Cancellation	Rating 7.3 1,106 reviews	Search GOL flights

Why use momondo?

Why should I use momondo to find a flight deal from Raleigh to South America?

Finding the right flight to South America from Raleigh is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South America quick and easy, saving you time and money.

Can I find flights from Raleigh to South America with flexible booking policies on momondo?

Flights from Raleigh to South America with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Raleigh to South America?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Raleigh to South America.

I’m not ready to book a flight from Raleigh to South America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South America from Raleigh. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Start using Trips

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Find better results for your trip to South America

Popular cities in South America

Flights to Limafrom $327

Flights to Buenos Airesfrom $552

Flights to Bogotáfrom $180

Flights to Sao Paulofrom $351

Flights to Medellínfrom $165

Flights to Rio de Janeirofrom $404

Flights to Santiagofrom $395

Flights to Cartagenafrom $181

Flights to Quitofrom $277

Flights to Cuscofrom $361

Flights to Califrom $195

Flights to Guayaquilfrom $242

Cheap flights from Raleigh to South America from $105

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Raleigh to South America departing on 12/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

Trusted and free

Price Alerts

Price Alerts

Find the cheapest flights from Raleigh to South America

Cheap round-trip flights

Cheap one-way flights

Cheap last minute flights

American Airlines flights from Raleigh to South America

Our best American Airlines deals on Raleigh to South America flight tickets

Copa Airlines flights from Raleigh to South America

Our best Copa Airlines deals on Raleigh to South America flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from Raleigh to South America that are best for you.

How to get the cheapest flight ticket from Raleigh to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Raleigh to South America is on a Monday when prices can be found for as low as $594. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Raleigh to South America for around $711.

What is the cheapest time of day to depart on your flight to South America?

How far in advance should I book a flight to South America?

Can stopping save me money on Raleigh to South America flights?

You could potentially save up to 56% on your flight if you consider stops on a Raleigh to South America flight.

What is the cheapest airline that flies from Raleigh-Durham to South America?

JetBlue, United Airlines, and American Airlines are the most popular carriers operating from Raleigh-Durham to South America

What airlines fly to South America?

Cheap Raleigh to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Raleigh to South America

Direct flights

When did momondo last update prices for flights from Raleigh-Durham Airport to South America?

How many operators does momondo search for flights from Raleigh-Durham Airport to South America?

How old do you have to be to fly from Raleigh-Durham Airport to South America?

What documentation or ID do you need to fly to South America?

Best airlines flying from Raleigh to South America

Compare and see reviews for airlines that fly from Raleigh to South America with momondo

Why use momondo?

Why should I use momondo to find a flight deal from Raleigh to South America?

Can I find flights from Raleigh to South America with flexible booking policies on momondo?

How can momondo help me find flights from Raleigh to South America?

I’m not ready to book a flight from Raleigh to South America right now. Can momondo alert me if prices change?

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo