What is the cheapest airline that flies from Raleigh-Durham to South America?

United Airlines, American Airlines, and Copa Airlines are the most popular carriers operating from Raleigh-Durham to South America

What airlines fly to South America?

American Airlines, Copa Airlines and Delta are the top three most popular airlines that fly to South America from Raleigh according to our data. American Airlines is the first choice among our users, with 28% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 7 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Raleigh-Durham Airport to South America?

Prices for flights from Raleigh-Durham Airport to South America refresh daily.

How many operators does momondo search for flights from Raleigh-Durham Airport to South America?

The number of operators available for flights from Raleigh-Durham Airport to South America is 7 as of September 2026.

How old do you have to be to fly from Raleigh-Durham Airport to South America?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Raleigh-Durham Airport to South America.

What documentation or ID do you need to fly to South America?

The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$141 Cheap Flights from Raleigh to South America in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Raleigh to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

3:17 pm - 6:05 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

26h 48m1 stop Panama City Tocumen Intl

6:25 am - 1:27 pmCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

7h 02m1 stop Panama City Tocumen Intl

$309Copa Airlines

Wed, Nov 4 - Wed, Nov 18

4:19 pm - 8:40 amRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

17h 21m1 stop Panama City Tocumen Intl

6:25 am - 2:28 pmCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

7h 03m1 stop Panama City Tocumen Intl

$319Copa Airlines

Wed, Oct 21 - Mon, Oct 26

5:00 am - 1:35 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

8h 35m1 stop Miami

4:37 pm - 12:24 amCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

7h 47m1 stop Miami

$335American Airlines

Sat, Nov 7 - Sat, Nov 14

8:25 pm - 3:36 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

20h 11m2 stops Chicago O'Hare Intl Miami

2:35 pm - 12:00 pmCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

21h 25m2 stops Miami Charlotte Douglas

$340American Airlines

Sat, Oct 31 - Sat, Nov 7

8:00 pm - 10:10 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

26h 10m2 stops Washington, D.C. Dulles Intl Houston George Bush Intcntl

10:40 am - 10:07 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

11h 27m1 stop Houston George Bush Intcntl

$346United Airlines

Sat, Nov 7 - Sun, Dec 6

5:19 pm - 9:15 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

28h 56m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

10:40 am - 9:33 amMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

22h 53m2 stops Houston George Bush Intcntl Washington, D.C. Dulles Intl

$346United Airlines

Thu, Oct 29 - Thu, Nov 5

6:30 am - 12:44 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

6h 14m1 stop Fort Lauderdale

1:50 pm - 9:18 pmCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

7h 28m1 stop Fort Lauderdale

$359JetBlue

Mon, Nov 2 - Thu, Nov 19

6:30 am - 12:44 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

6h 14m1 stop Fort Lauderdale

1:50 pm - 9:18 pmCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

7h 28m1 stop Fort Lauderdale

$359JetBlue

Mon, Nov 2 - Fri, Nov 20

5:15 am - 2:19 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

9h 04m1 stop Atlanta Hartsfield-Jackson

3:34 pm - 11:18 pmCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

7h 44m1 stop Atlanta Hartsfield-Jackson

$369Delta

Mon, Nov 30 - Mon, Dec 7

7:00 am - 2:25 pmRDU Raleigh-Durham-BOG Bogotá El Dorado

7h 25m1 stop Atlanta Hartsfield-Jackson

3:55 pm - 12:24 amBOG Bogotá El Dorado-RDU Raleigh-Durham

8h 29m1 stop Atlanta Hartsfield-Jackson

$385Delta

Wed, Nov 4 - Fri, Nov 20

Cheap last minute flights

Enter your travel dates to find the best prices.

4:21 pm - 8:15 amRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

16h 54m1 stop Panama City Tocumen Intl

6:20 pm - 2:28 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

19h 08m1 stop Panama City Tocumen Intl

$419Copa Airlines

Sun, Sep 20 - Thu, Oct 8

4:21 pm - 8:15 amRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

16h 54m1 stop Panama City Tocumen Intl

6:20 pm - 2:28 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

19h 08m1 stop Panama City Tocumen Intl

$420Copa Airlines

Sun, Sep 20 - Sun, Oct 4

4:21 pm - 8:15 amRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

16h 54m1 stop Panama City Tocumen Intl

6:15 pm - 2:24 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

19h 09m2 stops Lima J Chavez Intl New York John F Kennedy Intl

$427Multiple Airlines

Sun, Sep 20 - Tue, Sep 22

6:30 am - 9:10 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

15h 40m1 stop Houston George Bush Intcntl

9:45 am - 9:59 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

11h 14m1 stop Houston George Bush Intcntl

$454United Airlines

Sun, Sep 20 - Tue, Sep 22

5:30 pm - 12:35 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

20h 05m2 stops Philadelphia Miami

1:35 pm - 12:09 pmCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

21h 34m2 stops Miami Philadelphia

$456American Airlines

Sat, Sep 19 - Fri, Sep 25

4:21 pm - 8:15 amRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

16h 54m1 stop Panama City Tocumen Intl

11:15 pm - 5:59 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

17h 44m2 stops Bogotá El Dorado Orlando

$457Multiple Airlines

Sun, Sep 20 - Tue, Sep 22

7:25 am - 7:15 pmRDU Raleigh-Durham-BOG Bogotá El Dorado

12h 50m1 stop Atlanta Hartsfield-Jackson

2:55 pm - 12:28 amBOG Bogotá El Dorado-RDU Raleigh-Durham

8h 33m1 stop Atlanta Hartsfield-Jackson

$459LATAM Airlines

Sun, Sep 20 - Thu, Oct 8

12:31 pm - 7:15 pmRDU Raleigh-Durham-BOG Bogotá El Dorado

7h 44m1 stop Atlanta Hartsfield-Jackson

2:55 pm - 12:28 amBOG Bogotá El Dorado-RDU Raleigh-Durham

8h 33m1 stop Atlanta Hartsfield-Jackson

$459LATAM Airlines

Sun, Sep 20 - Tue, Sep 22

11:42 am - 10:30 pmRDU Raleigh-Durham-BOG Bogotá El Dorado

11h 48m1 stop Dallas/Fort Worth

6:30 am - 4:10 pmBOG Bogotá El Dorado-RDU Raleigh-Durham

8h 40m1 stop Miami

$463American Airlines

Tue, Sep 22 - Mon, Sep 28

5:05 pm - 4:54 amRDU Raleigh-Durham-BOG Bogotá El Dorado

12h 49m1 stop Houston George Bush Intcntl

8:30 am - 10:47 amBOG Bogotá El Dorado-RDU Raleigh-Durham

25h 17m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$464United Airlines

Sun, Sep 20 - Tue, Sep 22

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American Airlines flights from Raleigh to South America

Our best American Airlines deals on Raleigh to South America flight tickets

American Airlines

Nov 7

RDU5:00 amRaleigh-Durham

8h 35m

1 stop

CTG1:35 pmCartagena Rafael Nunez

Nov 14

CTG4:37 pmCartagena Rafael Nunez

7h 47m

1 stop

RDU12:24 amRaleigh-Durham

$335

American Airlines

Nov 7

RDU7:22 pmRaleigh-Durham

18h 13m

2 stops

CTG1:35 pmCartagena Rafael Nunez

Nov 14

CTG4:37 pmCartagena Rafael Nunez

19h 23m

2 stops

RDU12:00 pmRaleigh-Durham

$340

American Airlines

Nov 5

RDU6:26 pmRaleigh-Durham

19h 09m

2 stops

CTG1:35 pmCartagena Rafael Nunez

Nov 10

CTG2:35 pmCartagena Rafael Nunez

19h 15m

2 stops

RDU9:50 amRaleigh-Durham

$350

LATAM Airlines flights from Raleigh to South America

Our best LATAM Airlines deals on Raleigh to South America flight tickets

LATAM Airlines

Nov 4

RDU7:00 amRaleigh-Durham

7h 25m

1 stop

BOG2:25 pmBogotá El Dorado

Nov 18

BOG10:45 amBogotá El Dorado

9h 05m

1 stop

RDU7:50 pmRaleigh-Durham

$374

LATAM Airlines

Feb 24

RDU8:20 amRaleigh-Durham

11h 50m

1 stop

BOG8:10 pmBogotá El Dorado

Mar 3

BOG10:45 amBogotá El Dorado

10h 11m

1 stop

RDU8:56 pmRaleigh-Durham

$375

LATAM Airlines

Feb 4

RDU8:20 amRaleigh-Durham

11h 50m

1 stop

BOG8:10 pmBogotá El Dorado

Feb 9

BOG10:45 amBogotá El Dorado

10h 11m

1 stop

RDU8:56 pmRaleigh-Durham

$388

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Wed 11/4

3:17 pm-6:05 pm

1 stop26h 48m

Cartagena Rafael Nunez

Wed 11/18

6:25 am-1:27 pm

1 stop7h 02m

$309

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Wed 10/21

4:19 pm-8:40 am

1 stop17h 21m

Cartagena Rafael Nunez

Mon 10/26

6:25 am-2:28 pm

1 stop7h 03m

$319

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Sat 11/7

5:00 am-1:35 pm

1 stop8h 35m

Cartagena Rafael Nunez

Sat 11/14

4:37 pm-12:24 am

1 stop7h 47m

$335

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Sat 10/31

8:25 pm-3:36 pm

2 stops20h 11m

Cartagena Rafael Nunez

Sat 11/7

2:35 pm-12:00 pm

2 stops21h 25m

$340

RaleighMedellín

RDU Raleigh-Durham - MDE Medellín Jose Maria Cordova Intl

RDUMDE

Raleigh-Durham

Sat 11/7

8:00 pm-10:10 pm

2 stops26h 10m

Medellín Jose Maria Cordova Intl

Sun 12/6

10:40 am-10:07 pm

1 stop11h 27m

$346

RaleighMedellín

RDU Raleigh-Durham - MDE Medellín Jose Maria Cordova Intl

RDUMDE

Raleigh-Durham

Thu 10/29

5:19 pm-9:15 pm

2 stops28h 56m

Medellín Jose Maria Cordova Intl

Thu 11/5

10:40 am-9:33 am

2 stops22h 53m

$346

Quickest round-trip

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Mon 11/2

6:30 am-12:44 pm

1 stop6h 14m

Cartagena Rafael Nunez

Thu 11/19

1:50 pm-9:18 pm

1 stop7h 28m

$359

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Mon 11/2

6:30 am-12:44 pm

1 stop6h 14m

Cartagena Rafael Nunez

Fri 11/20

1:50 pm-9:18 pm

1 stop7h 28m

$359

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Mon 11/30

5:15 am-2:19 pm

1 stop9h 04m

Cartagena Rafael Nunez

Mon 12/7

3:34 pm-11:18 pm

1 stop7h 44m

$369

RaleighBogotá

RDU Raleigh-Durham - BOG Bogotá El Dorado

RDUBOG

Raleigh-Durham

Wed 11/4

7:00 am-2:25 pm

1 stop7h 25m

Bogotá El Dorado

Fri 11/20

3:55 pm-12:24 am

1 stop8h 29m

$385

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Raleigh to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from Raleigh to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $539. If you aren’t able to travel during the month of February, then book flights to South America from Raleigh during April instead. Flights to South America in April, while not as cheap as those in February, still average around $555.

How far in advance should I book a flight from Raleigh to South America?

You are more likely to see cheaper flights to South America from Raleigh when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $637 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Raleigh for as low as $573 on momondo.

Can stopping save me money on Raleigh to South America flights?

You could potentially save up to 19% on your flight if you consider stops on a Raleigh to South America flight.

Cheap Raleigh to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Raleigh to South America

Best Price Found	$141
Fastest flight time	6h 14m
Direct flights	None

The best one-way flight to South America from Raleigh in the past 72 hours is $141. The best round-trip flight deal from Raleigh to South America found on momondo in the last 72 hours is $309.

The fastest flight from Raleigh to South America takes 6h 14m

There are no direct flights from Raleigh to South America. There are no popular flight routes from Raleigh to South America.

Search flight deals

Frequently asked questions about flying from Raleigh to South America

When did momondo last update prices for flights from Raleigh-Durham Airport to South America?
Prices for flights from Raleigh-Durham Airport to South America refresh daily.
How many operators does momondo search for flights from Raleigh-Durham Airport to South America?
The number of operators available for flights from Raleigh-Durham Airport to South America is 7 as of September 2026.
How old do you have to be to fly from Raleigh-Durham Airport to South America?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Raleigh-Durham Airport to South America.
What documentation or ID do you need to fly to South America?
The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Raleigh to South America

Compare and see reviews for airlines that fly from Raleigh to South America with momondo

Airline	Rating	Free Cancellation	Price
JetBlue	PriceFrom $197	Free Cancellation	Rating 7.1 3,035 reviews	Search JetBlue flights
Copa Airlines	PriceFrom $216	Free Cancellation	Rating 7.6 1,543 reviews	Search Copa Airlines flights
United Airlines	PriceFrom $264	Free Cancellation	Rating 7.4 10,214 reviews	Search United Airlines flights
American Airlines	PriceFrom $278	Free Cancellation	Rating 7.1 12,070 reviews	Search American Airlines flights
Delta	PriceFrom $337	Free Cancellation	Rating 7.8 8,576 reviews	Search Delta flights
LATAM Airlines	PriceFrom $344	Free Cancellation	Rating 7.4 1,985 reviews	Search LATAM Airlines flights
GOL	PriceFrom $651	Free Cancellation	Rating 7.3 1,304 reviews	Search GOL flights

Why use momondo?

Why should I use momondo to find a flight deal from Raleigh to South America?

Finding the right flight to South America from Raleigh is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South America quick and easy, saving you time and money.

Can I find flights from Raleigh to South America with flexible booking policies on momondo?

Flights from Raleigh to South America with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Raleigh to South America?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Raleigh to South America.

I’m not ready to book a flight from Raleigh to South America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South America from Raleigh. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.