What is the cheapest airline that flies from Raleigh-Durham to South America?

Frontier, Copa Airlines, and American Airlines are the most popular carriers operating from Raleigh-Durham to South America

What airlines fly to South America?

American Airlines, Copa Airlines and LATAM Airlines are the top three most popular airlines that fly to South America from Raleigh according to our data. American Airlines is the first choice among our users, with 27% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 7 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Raleigh-Durham Airport to South America?

Prices for flights from Raleigh-Durham Airport to South America refresh daily.

How many operators does momondo search for flights from Raleigh-Durham Airport to South America?

The number of operators available for flights from Raleigh-Durham Airport to South America is 7 as of October 2026.

How old do you have to be to fly from Raleigh-Durham Airport to South America?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Raleigh-Durham Airport to South America.

What documentation or ID do you need to fly to South America?

The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$137 Cheap Flights from Raleigh to South America in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Raleigh to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:00 am - 3:36 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

9h 36m2 stops Philadelphia Miami

2:35 pm - 8:22 amCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

17h 47m2 stops Miami Washington, D.C. Reagan-National

$317American Airlines

Sun, Nov 8 - Fri, Nov 13

6:00 am - 3:36 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

9h 36m2 stops Philadelphia Miami

2:35 pm - 12:24 amCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

9h 49m1 stop Miami

$317American Airlines

Sun, Nov 8 - Fri, Nov 13

3:12 pm - 8:15 amRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

17h 03m1 stop Panama City Tocumen Intl

6:25 am - 1:16 pmCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

6h 51m1 stop Panama City Tocumen Intl

$323Copa Airlines

Fri, Jan 22 - Sun, Jan 24

7:41 am - 2:19 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

6h 38m1 stop Atlanta Hartsfield-Jackson

3:34 pm - 12:24 amCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

8h 50m1 stop Atlanta Hartsfield-Jackson

$341Delta

Mon, Nov 9 - Wed, Nov 18

10:38 am - 11:05 amRDU Raleigh-Durham-BOG Bogotá El Dorado

24h 27m1 stop Orlando

3:20 pm - 9:43 amBOG Bogotá El Dorado-RDU Raleigh-Durham

18h 23m1 stop Orlando

$353Frontier

Wed, Jan 20 - Tue, Jan 26

8:01 pm - 2:50 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

18h 49m2 stops Washington, D.C. Dulles Intl Houston George Bush Intcntl

4:00 pm - 5:41 pmCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

25h 41m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$357United Airlines

Fri, Jan 15 - Tue, Jan 19

3:17 pm - 10:55 amRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

19h 38m1 stop Panama City Tocumen Intl

4:30 pm - 1:27 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

20h 57m1 stop Panama City Tocumen Intl

$380Copa Airlines

Sun, Nov 1 - Thu, Nov 12

9:40 pm - 11:05 amRDU Raleigh-Durham-BOG Bogotá El Dorado

13h 25m1 stop Orlando

3:20 pm - 9:43 amBOG Bogotá El Dorado-RDU Raleigh-Durham

18h 23m1 stop Orlando

$391Frontier

Fri, Jan 22 - Tue, Jan 26

8:20 am - 10:05 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

13h 45m2 stops Miami Bogotá El Dorado

5:35 am - 8:56 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

15h 21m2 stops Bogotá El Dorado Miami

$412Delta

Sat, Jan 23 - Sat, Jan 30

6:30 am - 10:10 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

15h 40m1 stop Houston George Bush Intcntl

10:40 am - 10:11 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

11h 31m1 stop Houston George Bush Intcntl

$423United Airlines

Sun, Feb 14 - Sat, Feb 27

Cheap last minute flights

Enter your travel dates to find the best prices.

4:19 pm - 9:45 amRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

18h 26m1 stop Panama City Tocumen Intl

5:00 am - 1:27 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

8h 27m1 stop Panama City Tocumen Intl

$380Copa Airlines

Wed, Oct 28 - Wed, Nov 4

4:19 pm - 2:45 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

23h 26m1 stop Panama City Tocumen Intl

5:00 am - 1:27 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

8h 27m1 stop Panama City Tocumen Intl

$400Copa Airlines

Mon, Oct 26 - Mon, Nov 2

8:20 pm - 12:48 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

17h 28m2 stops Charlotte Douglas Miami

1:30 am - 3:02 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

13h 32m2 stops Miami Chicago O'Hare Intl

$419GOL

Mon, Oct 26 - Sun, Nov 1

7:13 pm - 12:48 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

18h 35m2 stops Charlotte Douglas Miami

1:50 pm - 10:17 amMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

19h 27m2 stops Miami Charlotte Douglas

$419GOL

Sat, Oct 24 - Fri, Oct 30

4:19 pm - 8:15 amRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

16h 56m1 stop Panama City Tocumen Intl

6:10 pm - 10:09 amMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

15h 59m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson

$472Multiple Airlines

Wed, Oct 28 - Wed, Nov 4

8:10 am - 11:35 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

16h 25m2 stops Miami Bogotá El Dorado

9:20 am - 7:53 pmCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

34h 33m2 stops Bogotá El Dorado Miami

$474Delta

Fri, Oct 23 - Sun, Nov 1

12:40 pm - 1:15 pmRDU Raleigh-Durham-CTG Cartagena Rafael Nunez

25h 35m1 stop Atlanta Hartsfield-Jackson

9:20 am - 7:53 pmCTG Cartagena Rafael Nunez-RDU Raleigh-Durham

34h 33m2 stops Bogotá El Dorado Miami

$474Delta

Fri, Oct 23 - Sun, Nov 1

6:30 am - 9:10 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

15h 40m1 stop Houston George Bush Intcntl

9:45 am - 9:59 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

11h 14m1 stop Houston George Bush Intcntl

$489United Airlines

Fri, Oct 23 - Sun, Oct 25

6:30 am - 9:10 pmRDU Raleigh-Durham-MDE Medellín Jose Maria Cordova Intl

15h 40m1 stop Houston George Bush Intcntl

9:45 am - 12:24 pmMDE Medellín Jose Maria Cordova Intl-RDU Raleigh-Durham

25h 39m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$493United Airlines

Fri, Oct 23 - Sun, Oct 25

6:38 pm - 10:45 amRDU Raleigh-Durham-GYE Guayaquil Jose Joaquin de Olmedo

17h 07m1 stop New York John F Kennedy Intl

8:00 pm - 5:48 pmGYE Guayaquil Jose Joaquin de Olmedo-RDU Raleigh-Durham

21h 48m1 stop New York John F Kennedy Intl

$558Multiple Airlines

Tue, Oct 27 - Tue, Nov 3

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LATAM Airlines flights from Raleigh to South America

Our best LATAM Airlines deals on Raleigh to South America flight tickets

LATAM Airlines

Feb 27

RDU6:35 amRaleigh-Durham

7h 35m

1 stop

CTG2:10 pmCartagena Rafael Nunez

Mar 3

CTG3:25 pmCartagena Rafael Nunez

8h 58m

1 stop

RDU12:23 amRaleigh-Durham

$369

LATAM Airlines

Feb 27

RDU6:35 amRaleigh-Durham

7h 35m

1 stop

CTG2:10 pmCartagena Rafael Nunez

Mar 3

CTG6:15 amCartagena Rafael Nunez

13h 31m

2 stops

RDU7:46 pmRaleigh-Durham

$399

LATAM Airlines

Feb 18

RDU8:20 amRaleigh-Durham

11h 50m

1 stop

BOG8:10 pmBogotá El Dorado

Mar 1

BOG10:45 amBogotá El Dorado

9h 01m

1 stop

RDU7:46 pmRaleigh-Durham

$402

Copa Airlines flights from Raleigh to South America

Our best Copa Airlines deals on Raleigh to South America flight tickets

Copa Airlines

Jan 22

RDU3:12 pmRaleigh-Durham

17h 03m

1 stop

CTG8:15 amCartagena Rafael Nunez

Jan 24

CTG6:25 amCartagena Rafael Nunez

6h 51m

1 stop

RDU1:16 pmRaleigh-Durham

$323

Copa Airlines

Nov 1

RDU3:17 pmRaleigh-Durham

19h 38m

1 stop

MDE10:55 amMedellín Jose Maria Cordova Intl

Nov 12

MDE4:30 pmMedellín Jose Maria Cordova Intl

20h 57m

1 stop

RDU1:27 pmRaleigh-Durham

$380

Copa Airlines

Nov 1

RDU3:17 pmRaleigh-Durham

18h 28m

1 stop

MDE9:45 amMedellín Jose Maria Cordova Intl

Nov 12

MDE8:35 amMedellín Jose Maria Cordova Intl

28h 52m

1 stop

RDU1:27 pmRaleigh-Durham

$381

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Sun 11/8

6:00 am-3:36 pm

2 stops9h 36m

Cartagena Rafael Nunez

Fri 11/13

2:35 pm-8:22 am

2 stops17h 47m

$317

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Sun 11/8

6:00 am-3:36 pm

2 stops9h 36m

Cartagena Rafael Nunez

Fri 11/13

2:35 pm-12:24 am

1 stop9h 49m

$317

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Fri 1/22

3:12 pm-8:15 am

1 stop17h 03m

Cartagena Rafael Nunez

Sun 1/24

6:25 am-1:16 pm

1 stop6h 51m

$323

Quickest round-trip

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Mon 11/9

7:41 am-2:19 pm

1 stop6h 38m

Cartagena Rafael Nunez

Wed 11/18

3:34 pm-12:24 am

1 stop8h 50m

$341

RaleighBogotá

RDU Raleigh-Durham - BOG Bogotá El Dorado

RDUBOG

Raleigh-Durham

Wed 1/20

10:38 am-11:05 am

1 stop24h 27m

Bogotá El Dorado

Tue 1/26

3:20 pm-9:43 am

1 stop18h 23m

$353

RaleighCartagena

RDU Raleigh-Durham - CTG Cartagena Rafael Nunez

RDUCTG

Raleigh-Durham

Fri 1/15

8:01 pm-2:50 pm

2 stops18h 49m

Cartagena Rafael Nunez

Tue 1/19

4:00 pm-5:41 pm

2 stops25h 41m

$357

RaleighMedellín

RDU Raleigh-Durham - MDE Medellín Jose Maria Cordova Intl

RDUMDE

Raleigh-Durham

Sun 11/1

3:17 pm-10:55 am

1 stop19h 38m

Medellín Jose Maria Cordova Intl

Thu 11/12

4:30 pm-1:27 pm

1 stop20h 57m

$380

RaleighBogotá

RDU Raleigh-Durham - BOG Bogotá El Dorado

RDUBOG

Raleigh-Durham

Fri 1/22

9:40 pm-11:05 am

1 stop13h 25m

Bogotá El Dorado

Tue 1/26

3:20 pm-9:43 am

1 stop18h 23m

$391

RaleighMedellín

RDU Raleigh-Durham - MDE Medellín Jose Maria Cordova Intl

RDUMDE

Raleigh-Durham

Sat 1/23

8:20 am-10:05 pm

2 stops13h 45m

Medellín Jose Maria Cordova Intl

Sat 1/30

5:35 am-8:56 pm

2 stops15h 21m

$412

RaleighMedellín

RDU Raleigh-Durham - MDE Medellín Jose Maria Cordova Intl

RDUMDE

Raleigh-Durham

Sun 2/14

6:30 am-10:10 pm

1 stop15h 40m

Medellín Jose Maria Cordova Intl

Sat 2/27

10:40 am-10:11 pm

1 stop11h 31m

$423

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Raleigh to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from Raleigh to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $528. If you aren’t able to travel during the month of February, then book flights to South America from Raleigh during April instead. Flights to South America in April, while not as cheap as those in February, still average around $558.

How far in advance should I book a flight from Raleigh to South America?

You are more likely to see cheaper flights to South America from Raleigh when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $657 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Raleigh for as low as $624 on momondo.

Can stopping save me money on Raleigh to South America flights?

You could potentially save up to 28% on your flight if you consider stops on a Raleigh to South America flight.

Cheap Raleigh to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Raleigh to South America

Best Price Found	$137
Fastest flight time	6h 30m
Direct flights	None

The best one-way flight to South America from Raleigh in the past 72 hours is $137. The best round-trip flight deal from Raleigh to South America found on momondo in the last 72 hours is $317.

The fastest flight from Raleigh to South America takes 6h 30m

There are no direct flights from Raleigh to South America. There are no popular flight routes from Raleigh to South America.

Search flight deals

Frequently asked questions about flying from Raleigh to South America

When did momondo last update prices for flights from Raleigh-Durham Airport to South America?
Prices for flights from Raleigh-Durham Airport to South America refresh daily.
How many operators does momondo search for flights from Raleigh-Durham Airport to South America?
The number of operators available for flights from Raleigh-Durham Airport to South America is 7 as of October 2026.
How old do you have to be to fly from Raleigh-Durham Airport to South America?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Raleigh-Durham Airport to South America.
What documentation or ID do you need to fly to South America?
The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Raleigh to South America

Compare and see reviews for airlines that fly from Raleigh to South America with momondo

Airline	Rating	Free Cancellation	Price
JetBlue	PriceFrom $172	Free Cancellation	Rating 7.1 3,062 reviews	Search JetBlue flights
Copa Airlines	PriceFrom $216	Free Cancellation	Rating 7.6 1,559 reviews	Search Copa Airlines flights
American Airlines	PriceFrom $278	Free Cancellation	Rating 7.0 12,192 reviews	Search American Airlines flights
United Airlines	PriceFrom $304	Free Cancellation	Rating 7.3 10,408 reviews	Search United Airlines flights
Delta	PriceFrom $343	Free Cancellation	Rating 7.8 8,666 reviews	Search Delta flights
LATAM Airlines	PriceFrom $344	Free Cancellation	Rating 7.4 1,971 reviews	Search LATAM Airlines flights
GOL	PriceFrom $623	Free Cancellation	Rating 7.3 1,326 reviews	Search GOL flights

Why use momondo?

Why should I use momondo to find a flight deal from Raleigh to South America?

Finding the right flight to South America from Raleigh is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South America quick and easy, saving you time and money.

Can I find flights from Raleigh to South America with flexible booking policies on momondo?

Flights from Raleigh to South America with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Raleigh to South America?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Raleigh to South America.

I’m not ready to book a flight from Raleigh to South America right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South America from Raleigh. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.