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Cheap flights from Prague to Des Moines from $461

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Prague to Des Moines departing on 9/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Prague to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:00 am - 5:28 pm-
18h 28m
United Airlines Logo
8:00 am - 1:55 pm-
22h 55m
$1,115United Airlines
Thu, Aug 20 - Mon, Aug 24
United Airlines Logo
7:05 am - 8:36 pm-
20h 31m
United Airlines Logo
6:45 pm - 10:40 pm-
20h 55m
$1,117United Airlines
Thu, Nov 5 - Mon, Nov 9
United Airlines Logo
7:05 am - 8:36 pm-
20h 31m
United Airlines Logo
6:45 pm - 10:40 pm-
20h 55m
$1,124United Airlines
Thu, Nov 5 - Mon, Nov 9
American Airlines Logo
10:15 am - 10:06 pm-
18h 51m
American Airlines Logo
5:40 am - 8:15 am-
19h 35m
$1,214American Airlines
Thu, Aug 20 - Mon, Aug 24
Delta Logo
11:15 am - 10:18 am-
30h 03m
Delta Logo
5:56 pm - 9:40 pm-
20h 44m
$1,300Delta
Mon, Aug 17 - Fri, Aug 21
American Airlines Logo
10:15 am - 10:06 pm-
18h 51m
American Airlines Logo
6:22 pm - 4:50 pm-
15h 28m
$1,366American Airlines
Mon, Aug 17 - Fri, Aug 21
American Airlines Logo
10:15 am - 12:34 pm-
33h 19m
American Airlines Logo
5:40 am - 8:15 am-
19h 35m
$1,377American Airlines
Mon, Aug 17 - Fri, Aug 21
Multiple Airlines Logo
6:00 am - 9:23 pm-
22h 23m
Multiple Airlines Logo
3:20 pm - 10:50 am-
36h 30m
$1,862Multiple Airlines
Thu, Aug 20 - Mon, Aug 24
Multiple Airlines Logo
12:30 pm - 10:26 am-
28h 56m
Multiple Airlines Logo
8:00 am - 8:30 am-
17h 30m
$1,871Multiple Airlines
Mon, Aug 17 - Fri, Aug 21
Air Canada Logo
6:00 am - 9:23 pm-
22h 23m
Air Canada Logo
1:21 pm - 1:30 pm-
17h 09m
$2,053Air Canada
Thu, Aug 20 - Mon, Aug 24

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United Airlines flights from Prague to Des Moines

Our best United Airlines deals on Prague to Des Moines flight tickets
United Airlines
Aug 20
PRG6:00 amVáclav Havel Prague
18h 28m
2 stops
DSM5:28 pmDes Moines
Aug 24
DSM8:00 amDes Moines
22h 55m
2 stops
PRG1:55 pmVáclav Havel Prague
$1,115
United Airlines
Nov 5
PRG7:05 amVáclav Havel Prague
20h 31m
2 stops
DSM8:36 pmDes Moines
Nov 9
DSM6:45 pmDes Moines
20h 55m
2 stops
PRG10:40 pmVáclav Havel Prague
$1,117
United Airlines
Nov 5
PRG7:05 amVáclav Havel Prague
20h 31m
2 stops
DSM8:36 pmDes Moines
Nov 9
DSM6:45 pmDes Moines
20h 55m
2 stops
PRG10:40 pmVáclav Havel Prague
$1,124

American Airlines flights from Prague to Des Moines

Our best American Airlines deals on Prague to Des Moines flight tickets
American Airlines
Aug 20
PRG10:15 amVáclav Havel Prague
18h 51m
1 stop
DSM10:06 pmDes Moines
Aug 24
DSM5:40 amDes Moines
19h 35m
1 stop
PRG8:15 amVáclav Havel Prague
$1,214
American Airlines
Aug 17
PRG10:15 amVáclav Havel Prague
18h 51m
1 stop
DSM10:06 pmDes Moines
Aug 21
DSM6:22 pmDes Moines
15h 28m
2 stops
PRG4:50 pmVáclav Havel Prague
$1,366
American Airlines
Aug 17
PRG10:15 amVáclav Havel Prague
33h 19m
1 stop
DSM12:34 pmDes Moines
Aug 21
DSM5:40 amDes Moines
19h 35m
1 stop
PRG8:15 amVáclav Havel Prague
$1,377

momondo Fare Finder

 
Customize your flight search to find flights from Prague to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 5, 2026.
Use the filters below to find and compare flights from Prague to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PragueDes Moines

PRG - DSM

PRGDSM

Václav Havel Prague

Thu 8/20

6:00 am-5:28 pm

2 stops18h 28m

Des Moines

Mon 8/24

8:00 am-1:55 pm

2 stops22h 55m

$1,115

PragueDes Moines

PRG - DSM

PRGDSM

Václav Havel Prague

Thu 11/5

7:05 am-8:36 pm

2 stops20h 31m

Des Moines

Mon 11/9

6:45 pm-10:40 pm

2 stops20h 55m

$1,117

PragueDes Moines

PRG - DSM

PRGDSM

Václav Havel Prague

Thu 11/5

7:05 am-8:36 pm

2 stops20h 31m

Des Moines

Mon 11/9

6:45 pm-10:40 pm

2 stops20h 55m

$1,124

PragueDes Moines

PRG - DSM

PRGDSM

Václav Havel Prague

Thu 8/20

10:15 am-10:06 pm

1 stop18h 51m

Des Moines

Mon 8/24

5:40 am-8:15 am

1 stop19h 35m

$1,214

PragueDes Moines

PRG - DSM

PRGDSM

Václav Havel Prague

Mon 8/17

11:15 am-10:18 am

2 stops30h 03m

Des Moines

Fri 8/21

5:56 pm-9:40 pm

2 stops20h 44m

$1,300
Quickest round-trip

PragueDes Moines

PRG - DSM

PRGDSM

Václav Havel Prague

Mon 8/17

10:15 am-10:06 pm

1 stop18h 51m

Des Moines

Fri 8/21

6:22 pm-4:50 pm

2 stops15h 28m

$1,366

PragueDes Moines

PRG - DSM

PRGDSM

Václav Havel Prague

Mon 8/17

10:15 am-12:34 pm

1 stop33h 19m

Des Moines

Fri 8/21

5:40 am-8:15 am

1 stop19h 35m

$1,377

PragueDes Moines

PRG - DSM

PRGDSM

Václav Havel Prague

Thu 8/20

6:00 am-9:23 pm

3 stops22h 23m

Des Moines

Mon 8/24

3:20 pm-10:50 am

2 stops36h 30m

$1,862

PragueDes Moines

PRG - DSM

PRGDSM

Václav Havel Prague

Mon 8/17

12:30 pm-10:26 am

2 stops28h 56m

Des Moines

Fri 8/21

8:00 am-8:30 am

3 stops17h 30m

$1,871

PragueDes Moines

PRG - DSM

PRGDSM

Václav Havel Prague

Thu 8/20

6:00 am-9:23 pm

3 stops22h 23m

Des Moines

Mon 8/24

1:21 pm-1:30 pm

3 stops17h 09m

$2,053

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Prague to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Prague to Des Moines flights?

You could potentially save up to 23% on your flight if you consider stops on a Prague to Des Moines flight.

When to book flights from Prague to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Prague to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Prague to Des Moines (PRG to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Prague to Des Moines

Fastest flight time

18h 28m

Direct flights

None
The fastest flight from Prague to Des Moines takes 18h 28m
There are no direct flights from Prague to Des Moines. There are no popular flight routes from Prague to Des Moines.
Search flight deals

Frequently asked questions about flying from Prague to Des Moines

  • How far is Václav Havel Prague to Des Moines by plane?

    The straight-line distance from Václav Havel Prague to Des Moines is 4755.3 mi. Flights usually cover this in 18h 28m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Václav Havel Prague Airport to Des Moines Airport?

    Prices for flights from Václav Havel Prague Airport to Des Moines Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Václav Havel Prague Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Václav Havel Prague Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The travel and health documents you'll need for your trip to Des Moines Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Des Moines Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Urbandale
Newton
Osceola
Johnston
Boone
Oskaloosa
Norwalk
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Prague to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Prague to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Prague to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Prague which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Prague to Des Moines?

momondo helps you find the best flight between Prague and Des Moines by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Prague to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Prague are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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