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Cheap flights from Pittsburgh to South America from $164

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Pittsburgh to South America departing on 12/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

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Spirit Airlines Logo
10:53 am - 1:09 amPIT-MDE
14h 16m1 stop
Spirit Airlines Logo
2:05 am - 9:58 amMDE-PIT
7h 53m1 stop
$191Spirit Airlines
Find Deal
Mon, Dec 8 - Wed, Dec 10
Spirit Airlines Logo
6:00 am - 2:13 pmPIT-MDE
8h 13m1 stop
Spirit Airlines Logo
3:10 pm - 11:42 pmMDE-PIT
8h 32m1 stop
$238Spirit Airlines
Find Deal
Wed, Feb 25 - Fri, Feb 27
American Airlines Logo
7:04 pm - 1:30 pmPIT-CTG
18h 26m2 stops
American Airlines Logo
2:30 pm - 11:59 pmCTG-PIT
9h 29m1 stop
$291American Airlines
Find Deal
Mon, Jan 26 - Thu, Jan 29
American Airlines Logo
7:04 pm - 3:30 pmPIT-CTG
20h 26m2 stops
American Airlines Logo
4:30 pm - 11:10 amCTG-PIT
18h 40m1 stop
$298American Airlines
Find Deal
Fri, Jan 16 - Sat, Jan 24
United Airlines Logo
1:00 pm - 10:05 pmPIT-MDE
9h 05m1 stop
United Airlines Logo
10:45 am - 10:14 pmMDE-PIT
11h 29m1 stop
$303United Airlines
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Mon, Dec 8 - Fri, Dec 12
Delta Logo
6:00 am - 2:17 pmPIT-CTG
8h 17m1 stop
Delta Logo
4:35 am - 6:33 pmCTG-PIT
13h 58m2 stops
$360Delta
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Mon, Jan 26 - Wed, Jan 28
Delta Logo
6:00 am - 12:31 amPIT-CTG
18h 31m2 stops
Delta Logo
3:32 pm - 11:35 pmCTG-PIT
8h 03m1 stop
$362Delta
Find Deal
Mon, Jan 26 - Thu, Jan 29
LATAM Airlines Logo
1:41 pm - 9:35 pmPIT-UIO
7h 54m1 stop
LATAM Airlines Logo
11:45 pm - 9:10 amUIO-PIT
9h 25m1 stop
$564LATAM Airlines
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Mon, Jan 19 - Wed, Jan 28
United Airlines Logo
10:35 am - 12:30 amPIT-UIO
13h 55m2 stops
United Airlines Logo
1:35 am - 3:42 pmUIO-PIT
14h 07m1 stop
$569United Airlines
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Mon, Jan 19 - Tue, Jan 27
LATAM Airlines Logo
5:17 pm - 5:00 pmPIT-AEP
21h 43m2 stops
LATAM Airlines Logo
2:55 pm - 9:09 amAEP-PIT
20h 14m2 stops
$976LATAM Airlines
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Mon, Feb 23 - Thu, Mar 5

Avianca flights from Pittsburgh to South America

Our best Avianca deals on Pittsburgh to South America flight tickets
Avianca
Feb 6
PIT8:10 pmPittsburgh
15h 40m
2 stops
BOG11:50 amBogotá El Dorado
Feb 12
BOG4:00 amBogotá El Dorado
14h 51m
2 stops
PIT6:51 pmPittsburgh
$530
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Avianca
Jan 20
PIT2:57 pmPittsburgh
11h 53m
2 stops
UIO2:50 amQuito Mariscal Sucr
Jan 25
UIO3:30 amQuito Mariscal Sucr
15h 31m
2 stops
PIT7:01 pmPittsburgh
$549
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Copa Airlines flights from Pittsburgh to South America

Our best Copa Airlines deals on Pittsburgh to South America flight tickets
Copa Airlines
Feb 7
PIT10:35 amPittsburgh
23h 35m
2 stops
BOG10:10 amBogotá El Dorado
Feb 14
BOG12:08 pmBogotá El Dorado
21h 12m
2 stops
PIT9:20 amPittsburgh
$544
Find similar
Copa Airlines
Nov 27
PIT10:40 amPittsburgh
19h 20m
2 stops
GIG8:00 amRio de Janeiro–Galeão Intl
Dec 4
GIG9:55 amRio de Janeiro–Galeão Intl
25h 33m
2 stops
PIT9:28 amPittsburgh
$885
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momondo Fare Finder

 
Customize your flight search to find flights from Pittsburgh to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 25, 2025.
Use the filters below to find and compare flights from Pittsburgh to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PittsburghMedellín

PIT - MDE

PITMDE

Pittsburgh

Mon 12/8

10:53 am-1:09 am

1 stop14h 16m

Medellín Jose Maria Cordova Intl

Wed 12/10

2:05 am-9:58 am

1 stop7h 53m

$191

PittsburghMedellín

PIT - MDE

PITMDE

Pittsburgh

Wed 2/25

6:00 am-2:13 pm

1 stop8h 13m

Medellín Jose Maria Cordova Intl

Fri 2/27

3:10 pm-11:42 pm

1 stop8h 32m

$238

PittsburghCartagena

PIT - CTG

PITCTG

Pittsburgh

Mon 1/26

7:04 pm-1:30 pm

2 stops18h 26m

Cartagena Rafael Nunez

Thu 1/29

2:30 pm-11:59 pm

1 stop9h 29m

$291

PittsburghCartagena

PIT - CTG

PITCTG

Pittsburgh

Fri 1/16

7:04 pm-3:30 pm

2 stops20h 26m

Cartagena Rafael Nunez

Sat 1/24

4:30 pm-11:10 am

1 stop18h 40m

$298

PittsburghMedellín

PIT - MDE

PITMDE

Pittsburgh

Mon 12/8

1:00 pm-10:05 pm

1 stop9h 05m

Medellín Jose Maria Cordova Intl

Fri 12/12

10:45 am-10:14 pm

1 stop11h 29m

$303

PittsburghCartagena

PIT - CTG

PITCTG

Pittsburgh

Mon 1/26

6:00 am-2:17 pm

1 stop8h 17m

Cartagena Rafael Nunez

Wed 1/28

4:35 am-6:33 pm

2 stops13h 58m

$360

PittsburghCartagena

PIT - CTG

PITCTG

Pittsburgh

Mon 1/26

6:00 am-12:31 am

2 stops18h 31m

Cartagena Rafael Nunez

Thu 1/29

3:32 pm-11:35 pm

1 stop8h 03m

$362

PittsburghQuito

PIT - UIO

PITUIO

Pittsburgh

Mon 1/19

1:41 pm-9:35 pm

1 stop7h 54m

Quito Mariscal Sucr

Wed 1/28

11:45 pm-9:10 am

1 stop9h 25m

$564

PittsburghQuito

PIT - UIO

PITUIO

Pittsburgh

Mon 1/19

10:35 am-12:30 am

2 stops13h 55m

Quito Mariscal Sucr

Tue 1/27

1:35 am-3:42 pm

1 stop14h 07m

$569

PittsburghBuenos Aires

PIT - AEP

PITAEP

Pittsburgh

Mon 2/23

5:17 pm-5:00 pm

2 stops21h 43m

Buenos Aires Jorge Newbery

Thu 3/5

2:55 pm-9:09 am

2 stops20h 14m

$976

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Pittsburgh to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, September is the cheapest month to fly from Pittsburgh to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $634. If you aren’t able to travel during the month of September, then book flights to South America from Pittsburgh during March instead. Flights to South America in March, while not as cheap as those in September, still average around $687.

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Pittsburgh to South America is on a Monday when prices can be found for as low as $691. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Pittsburgh to South America for around $866.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest Pittsburgh to South America flights are usually those with departure times in the evening. Our users have found flights to South America in the evening for as low as $635. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $796 on average. Flights to South America from Pittsburgh in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from Pittsburgh when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $780 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Pittsburgh for as low as $634 on momondo.

Can stopping save me money on Pittsburgh to South America flights?

You could potentially save up to 46% on your flight if you consider stops on a Pittsburgh to South America flight.

Cheap Pittsburgh to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Pittsburgh to South America

Fastest flight time

7h 13m

Direct flights

None
The fastest flight from Pittsburgh to South America takes 7h 13m
There are no direct flights from Pittsburgh to South America. There are no popular flight routes from Pittsburgh to South America.
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  • When did momondo last update prices for flights from Pittsburgh Airport to South America?

    Prices for flights from Pittsburgh Airport to South America refresh daily.

  • How many operators does momondo search for flights from Pittsburgh Airport to South America?

  • How old do you have to be to fly from Pittsburgh Airport to South America?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Pittsburgh Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Pittsburgh to South America

Compare and see reviews for airlines that fly from Pittsburgh to South America with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $265Free CancellationRating
6.3
8,158 reviews
Search Spirit Airlines flights
JetBluePriceFrom $333Free CancellationRating
7.2
2,905 reviews
Search JetBlue flights
American AirlinesPriceFrom $488Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights
DeltaPriceFrom $501Free CancellationRating
7.9
7,999 reviews
Search Delta flights
LATAM AirlinesPriceFrom $548Free CancellationRating
7.5
1,887 reviews
Search LATAM Airlines flights
United AirlinesPriceFrom $593Free CancellationRating
7.4
9,046 reviews
Search United Airlines flights
Copa AirlinesPriceFrom $712Free CancellationRating
7.6
1,569 reviews
Search Copa Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Pittsburgh to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Pittsburgh to South America. momondo saves you time and could save you money on your trip.

Can I find flights from Pittsburgh to South America with flexible booking policies on momondo?

All flight searches from Pittsburgh to South America on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Pittsburgh to South America?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Pittsburgh to South America.

I’m not ready to book a flight from Pittsburgh to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Pittsburgh to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo
Flights to Limafrom $289
Flights to Buenos Airesfrom $520
Flights to Bogotáfrom $200
Flights to Sao Paulofrom $379
Flights to Rio de Janeirofrom $451
Flights to Medellínfrom $165
Flights to Santiagofrom $375
Flights to Cartagenafrom $169
Flights to Quitofrom $324
Flights to Cuscofrom $404
Flights to Guayaquilfrom $212
Flights to Califrom $202