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Cheap flights from Pittsburgh to South America from $121

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Pittsburgh to South America departing on 1/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Pittsburgh to South America

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
9:09 pm - 1:10 pm
PIT
-
CTG
16h 01m1 stop
Spirit Airlines Logo
2:21 pm - 11:59 pm
CTG
-
PIT
9h 38m1 stop
$242Spirit Airlines
Fri, Feb 20 - Fri, Feb 27
Spirit Airlines Logo
6:00 am - 2:15 pm
PIT
-
MDE
8h 15m1 stop
Spirit Airlines Logo
3:15 pm - 11:59 pm
MDE
-
PIT
8h 44m1 stop
$255Spirit Airlines
Wed, Feb 4 - Wed, Feb 18
JetBlue Logo
7:00 am - 2:55 pm
PIT
-
MDE
7h 55m1 stop
JetBlue Logo
2:25 pm - 11:10 pm
MDE
-
PIT
8h 45m1 stop
$258JetBlue
Wed, Feb 11 - Mon, Feb 16
JetBlue Logo
7:00 am - 2:50 pm
PIT
-
CTG
7h 50m1 stop
JetBlue Logo
2:20 pm - 11:55 pm
CTG
-
PIT
9h 35m1 stop
$280JetBlue
Sun, Jan 25 - Thu, Jan 29
American Airlines Logo
7:31 am - 9:10 pm
PIT
-
MDE
13h 39m2 stops
American Airlines Logo
12:20 am - 6:25 pm
MDE
-
PIT
17h 05m1 stop
$289American Airlines
Sun, Mar 1 - Mon, Mar 30
American Airlines Logo
7:05 pm - 1:30 pm
PIT
-
CTG
18h 25m2 stops
American Airlines Logo
4:30 pm - 10:27 am
CTG
-
PIT
17h 57m2 stops
$294American Airlines
Thu, Feb 5 - Mon, Feb 9
LATAM Airlines Logo
7:05 am - 1:15 pm
PIT
-
CTG
7h 10m1 stop
LATAM Airlines Logo
2:30 pm - 12:19 am
CTG
-
PIT
8h 49m1 stop
$357LATAM Airlines
Thu, Apr 2 - Tue, Apr 7
LATAM Airlines Logo
7:35 pm - 2:17 pm
PIT
-
CTG
18h 42m1 stop
LATAM Airlines Logo
5:05 am - 11:11 pm
CTG
-
PIT
18h 06m2 stops
$366LATAM Airlines
Fri, Feb 20 - Fri, Feb 27
Delta Logo
7:19 am - 9:35 pm
PIT
-
UIO
14h 16m1 stop
Delta Logo
11:45 pm - 12:36 pm
UIO
-
PIT
12h 51m1 stop
$565Delta
Wed, Feb 4 - Wed, Feb 11
Delta Logo
6:00 am - 9:35 pm
PIT
-
UIO
15h 35m1 stop
Delta Logo
7:00 pm - 12:36 pm
UIO
-
PIT
17h 36m2 stops
$590Delta
Sun, Feb 22 - Sun, Mar 1

Air Canada flights from Pittsburgh to South America

Our best Air Canada deals on Pittsburgh to South America flight tickets
Air Canada
Feb 3
PIT5:55 pmPittsburgh
32h 20m
2 stops
LIM2:15 amLima J Chavez Intl
Feb 18
LIM8:05 amLima J Chavez Intl
33h 09m
2 stops
PIT5:14 pmPittsburgh
$514
Air Canada
Jan 20
PIT5:55 pmPittsburgh
32h 20m
2 stops
LIM2:15 amLima J Chavez Intl
Feb 7
LIM8:05 amLima J Chavez Intl
33h 09m
2 stops
PIT5:14 pmPittsburgh
$610
Air Canada
Jan 22
PIT5:55 pmPittsburgh
16h 10m
1 stop
GIG12:05 pmRio de Janeiro–Galeão Intl
Jan 23
GIG9:00 pmRio de Janeiro–Galeão Intl
22h 14m
1 stop
PIT5:14 pmPittsburgh
$1,010

Spirit Airlines flights from Pittsburgh to South America

Our best Spirit Airlines deals on Pittsburgh to South America flight tickets
Spirit Airlines
Feb 20
PIT9:09 pmPittsburgh
16h 01m
1 stop
CTG1:10 pmCartagena Rafael Nunez
Feb 27
CTG2:21 pmCartagena Rafael Nunez
9h 38m
1 stop
PIT11:59 pmPittsburgh
$242
Spirit Airlines
Feb 4
PIT6:00 amPittsburgh
8h 15m
1 stop
MDE2:15 pmMedellín Jose Maria Cordova Intl
Feb 18
MDE3:15 pmMedellín Jose Maria Cordova Intl
8h 44m
1 stop
PIT11:59 pmPittsburgh
$255
Spirit Airlines
Feb 3
PIT6:00 amPittsburgh
16h 35m
1 stop
LIM10:35 pmLima J Chavez Intl
Feb 18
LIM11:30 pmLima J Chavez Intl
20h 44m
1 stop
PIT8:14 pmPittsburgh
$266

momondo Fare Finder

 
Customize your flight search to find flights from Pittsburgh to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from Pittsburgh to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PittsburghCartagena

PIT - CTG

PITCTG

Pittsburgh

Fri 2/20

9:09 pm-1:10 pm

1 stop16h 01m

Cartagena Rafael Nunez

Fri 2/27

2:21 pm-11:59 pm

1 stop9h 38m

$242

PittsburghMedellín

PIT - MDE

PITMDE

Pittsburgh

Wed 2/4

6:00 am-2:15 pm

1 stop8h 15m

Medellín Jose Maria Cordova Intl

Wed 2/18

3:15 pm-11:59 pm

1 stop8h 44m

$255

PittsburghMedellín

PIT - MDE

PITMDE

Pittsburgh

Wed 2/11

7:00 am-2:55 pm

1 stop7h 55m

Medellín Jose Maria Cordova Intl

Mon 2/16

2:25 pm-11:10 pm

1 stop8h 45m

$258

PittsburghCartagena

PIT - CTG

PITCTG

Pittsburgh

Sun 1/25

7:00 am-2:50 pm

1 stop7h 50m

Cartagena Rafael Nunez

Thu 1/29

2:20 pm-11:55 pm

1 stop9h 35m

$280

PittsburghMedellín

PIT - MDE

PITMDE

Pittsburgh

Sun 3/1

7:31 am-9:10 pm

2 stops13h 39m

Medellín Jose Maria Cordova Intl

Mon 3/30

12:20 am-6:25 pm

1 stop17h 05m

$289

PittsburghCartagena

PIT - CTG

PITCTG

Pittsburgh

Thu 2/5

7:05 pm-1:30 pm

2 stops18h 25m

Cartagena Rafael Nunez

Mon 2/9

4:30 pm-10:27 am

2 stops17h 57m

$294

PittsburghCartagena

PIT - CTG

PITCTG

Pittsburgh

Thu 4/2

7:05 am-1:15 pm

1 stop7h 10m

Cartagena Rafael Nunez

Tue 4/7

2:30 pm-12:19 am

1 stop8h 49m

$357

PittsburghCartagena

PIT - CTG

PITCTG

Pittsburgh

Fri 2/20

7:35 pm-2:17 pm

1 stop18h 42m

Cartagena Rafael Nunez

Fri 2/27

5:05 am-11:11 pm

2 stops18h 06m

$366

PittsburghQuito

PIT - UIO

PITUIO

Pittsburgh

Wed 2/4

7:19 am-9:35 pm

1 stop14h 16m

Quito Mariscal Sucr

Wed 2/11

11:45 pm-12:36 pm

1 stop12h 51m

$565

PittsburghQuito

PIT - UIO

PITUIO

Pittsburgh

Sun 2/22

6:00 am-9:35 pm

1 stop15h 35m

Quito Mariscal Sucr

Sun 3/1

7:00 pm-12:36 pm

2 stops17h 36m

$590

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Pittsburgh to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, September is the cheapest month to fly from Pittsburgh to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $624. If you aren’t able to travel during the month of September, then book flights to South America from Pittsburgh during April instead. Flights to South America in April, while not as cheap as those in September, still average around $684.

Can stopping save me money on Pittsburgh to South America flights?

You could potentially save up to 46% on your flight if you consider stops on a Pittsburgh to South America flight.

Cheap Pittsburgh to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Pittsburgh to South America

Fastest flight time

7h 10m

Direct flights

None
The fastest flight from Pittsburgh to South America takes 7h 10m
There are no direct flights from Pittsburgh to South America. There are no popular flight routes from Pittsburgh to South America.
Search flight deals

  • When did momondo last update prices for flights from Pittsburgh Airport to South America?

    Prices for flights from Pittsburgh Airport to South America refresh daily.

  • How many operators does momondo search for flights from Pittsburgh Airport to South America?

  • How old do you have to be to fly from Pittsburgh Airport to South America?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Pittsburgh Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Pittsburgh to South America

Compare and see reviews for airlines that fly from Pittsburgh to South America with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $265Free CancellationRating
6.3
8,287 reviews
Search Spirit Airlines flights
JetBluePriceFrom $333Free CancellationRating
7.2
2,896 reviews
Search JetBlue flights
United AirlinesPriceFrom $347Free CancellationRating
7.4
9,139 reviews
Search United Airlines flights
American AirlinesPriceFrom $458Free CancellationRating
7.2
11,095 reviews
Search American Airlines flights
DeltaPriceFrom $501Free CancellationRating
7.9
8,025 reviews
Search Delta flights
LATAM AirlinesPriceFrom $594Free CancellationRating
7.5
1,897 reviews
Search LATAM Airlines flights
Copa AirlinesPriceFrom $712Free CancellationRating
7.6
1,562 reviews
Search Copa Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Pittsburgh to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Pittsburgh to South America. momondo saves you time and could save you money on your trip.

Can I find flights from Pittsburgh to South America with flexible booking policies on momondo?

All flight searches from Pittsburgh to South America on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Pittsburgh to South America?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Pittsburgh to South America.

I’m not ready to book a flight from Pittsburgh to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Pittsburgh to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo
Flights to Limafrom $224
Flights to Buenos Airesfrom $457
Flights to Sao Paulofrom $381
Flights to Bogotáfrom $164
Flights to Rio de Janeirofrom $481
Flights to Medellínfrom $222
Flights to Santiagofrom $351
Flights to Cartagenafrom $168
Flights to Quitofrom $299
Flights to Cuscofrom $379
Flights to Guayaquilfrom $205
Flights to Califrom $167