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Cheap flights from Pittsburgh to South America from $106

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Pittsburgh to South America departing on 4/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Pittsburgh to South America

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
6:00 am - 2:13 pm
PIT
-
MDE
8h 13m
1 stop
Spirit Airlines Logo
3:15 pm - 11:59 pm
MDE
-
PIT
8h 44m
1 stop
$232Spirit Airlines
Sun, Feb 22 - Thu, Feb 26
Spirit Airlines Logo
9:09 pm - 2:13 pm
PIT
-
MDE
17h 04m
1 stop
Spirit Airlines Logo
3:15 pm - 11:59 pm
MDE
-
PIT
8h 44m
1 stop
$240Spirit Airlines
Mon, Mar 2 - Fri, Mar 6
American Airlines Logo
10:40 am - 10:39 pm
PIT
-
MDE
12h 59m
2 stops
American Airlines Logo
12:20 am - 2:36 pm
MDE
-
PIT
13h 16m
2 stops
$265American Airlines
Tue, Mar 10 - Mon, Mar 16
American Airlines Logo
7:05 pm - 12:31 pm
PIT
-
CTG
18h 26m
2 stops
American Airlines Logo
1:25 pm - 11:04 am
CTG
-
PIT
20h 39m
2 stops
$270American Airlines
Thu, Apr 2 - Tue, Apr 7
Delta Logo
1:43 pm - 9:35 pm
PIT
-
UIO
7h 52m
1 stop
Delta Logo
11:45 pm - 6:29 pm
UIO
-
PIT
17h 44m
1 stop
$586Delta
Wed, Mar 4 - Wed, Mar 25
Delta Logo
10:09 am - 5:17 am
PIT
-
UIO
19h 08m
2 stops
Delta Logo
11:45 pm - 12:37 pm
UIO
-
PIT
11h 52m
1 stop
$590Delta
Wed, Mar 4 - Wed, Mar 25
United Airlines Logo
12:35 pm - 5:00 am
PIT
-
UIO
17h 25m
1 stop
United Airlines Logo
12:35 am - 4:05 pm
UIO
-
PIT
14h 30m
1 stop
$606United Airlines
Sat, May 16 - Sat, May 23
United Airlines Logo
2:08 pm - 5:00 am
PIT
-
UIO
15h 52m
2 stops
United Airlines Logo
12:35 am - 3:24 pm
UIO
-
PIT
13h 49m
2 stops
$610United Airlines
Sat, May 16 - Sat, May 23
LATAM Airlines Logo
11:23 am - 5:55 am
PIT
-
SCL
17h 32m
1 stop
LATAM Airlines Logo
12:20 am - 6:29 pm
SCL
-
PIT
19h 09m
2 stops
$727LATAM Airlines
Mon, Mar 9 - Tue, Mar 17
LATAM Airlines Logo
11:23 am - 5:55 am
PIT
-
SCL
17h 32m
1 stop
LATAM Airlines Logo
12:20 am - 6:29 pm
SCL
-
PIT
19h 09m
2 stops
$731LATAM Airlines
Mon, Mar 9 - Tue, Mar 17

Spirit Airlines flights from Pittsburgh to South America

Our best Spirit Airlines deals on Pittsburgh to South America flight tickets
Spirit Airlines
Feb 22
PIT6:00 amPittsburgh
8h 13m
1 stop
MDE2:13 pmMedellín Jose Maria Cordova Intl
Feb 26
MDE3:15 pmMedellín Jose Maria Cordova Intl
8h 44m
1 stop
PIT11:59 pmPittsburgh
$232
Spirit Airlines
Mar 2
PIT9:09 pmPittsburgh
17h 04m
1 stop
MDE2:13 pmMedellín Jose Maria Cordova Intl
Mar 6
MDE3:15 pmMedellín Jose Maria Cordova Intl
8h 44m
1 stop
PIT11:59 pmPittsburgh
$240
Spirit Airlines
Mar 11
PIT6:00 amPittsburgh
8h 13m
1 stop
MDE1:13 pmMedellín Jose Maria Cordova Intl
Mar 19
MDE2:17 pmMedellín Jose Maria Cordova Intl
7h 57m
1 stop
PIT11:14 pmPittsburgh
$255

Copa Airlines flights from Pittsburgh to South America

Our best Copa Airlines deals on Pittsburgh to South America flight tickets
Copa Airlines
May 1
PIT10:35 amPittsburgh
15h 45m
2 stops
LIM1:20 amLima J Chavez Intl
May 8
LIM1:20 pmLima J Chavez Intl
19h 11m
2 stops
PIT9:31 amPittsburgh
$618
Copa Airlines
Jan 30
PIT8:10 pmPittsburgh
26h 54m
2 stops
EZE1:04 amBuenos Aires Ministro Pistarini
Feb 13
EZE2:48 pmBuenos Aires Ministro Pistarini
20h 37m
2 stops
PIT9:25 amPittsburgh
$1,219
Copa Airlines
Jan 30
PIT10:35 amPittsburgh
19h 22m
2 stops
EZE7:57 amBuenos Aires Ministro Pistarini
Feb 13
EZE9:16 amBuenos Aires Ministro Pistarini
26h 09m
2 stops
PIT9:25 amPittsburgh
$1,254

momondo Fare Finder

 
Customize your flight search to find flights from Pittsburgh to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 25, 2026.
Use the filters below to find and compare flights from Pittsburgh to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PittsburghMedellín

PIT - MDE

PITMDE

Pittsburgh

Sun 2/22

6:00 am-2:13 pm

1 stop8h 13m

Medellín Jose Maria Cordova Intl

Thu 2/26

3:15 pm-11:59 pm

1 stop8h 44m

$232

PittsburghMedellín

PIT - MDE

PITMDE

Pittsburgh

Mon 3/2

9:09 pm-2:13 pm

1 stop17h 04m

Medellín Jose Maria Cordova Intl

Fri 3/6

3:15 pm-11:59 pm

1 stop8h 44m

$240

PittsburghMedellín

PIT - MDE

PITMDE

Pittsburgh

Tue 3/10

10:40 am-10:39 pm

2 stops12h 59m

Medellín Jose Maria Cordova Intl

Mon 3/16

12:20 am-2:36 pm

2 stops13h 16m

$265

PittsburghCartagena

PIT - CTG

PITCTG

Pittsburgh

Thu 4/2

7:05 pm-12:31 pm

2 stops18h 26m

Cartagena Rafael Nunez

Tue 4/7

1:25 pm-11:04 am

2 stops20h 39m

$270

PittsburghQuito

PIT - UIO

PITUIO

Pittsburgh

Wed 3/4

1:43 pm-9:35 pm

1 stop7h 52m

Quito Mariscal Sucr

Wed 3/25

11:45 pm-6:29 pm

1 stop17h 44m

$586

PittsburghQuito

PIT - UIO

PITUIO

Pittsburgh

Wed 3/4

10:09 am-5:17 am

2 stops19h 08m

Quito Mariscal Sucr

Wed 3/25

11:45 pm-12:37 pm

1 stop11h 52m

$590

PittsburghQuito

PIT - UIO

PITUIO

Pittsburgh

Sat 5/16

12:35 pm-5:00 am

1 stop17h 25m

Quito Mariscal Sucr

Sat 5/23

12:35 am-4:05 pm

1 stop14h 30m

$606

PittsburghQuito

PIT - UIO

PITUIO

Pittsburgh

Sat 5/16

2:08 pm-5:00 am

2 stops15h 52m

Quito Mariscal Sucr

Sat 5/23

12:35 am-3:24 pm

2 stops13h 49m

$610

PittsburghSantiago

PIT - SCL

PITSCL

Pittsburgh

Mon 3/9

11:23 am-5:55 am

1 stop17h 32m

Santiago Arturo Merino Benitez

Tue 3/17

12:20 am-6:29 pm

2 stops19h 09m

$727

PittsburghSantiago

PIT - SCL

PITSCL

Pittsburgh

Mon 3/9

11:23 am-5:55 am

1 stop17h 32m

Santiago Arturo Merino Benitez

Tue 3/17

12:20 am-6:29 pm

2 stops19h 09m

$731

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Pittsburgh to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, September is the cheapest month to fly from Pittsburgh to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $624. If you aren’t able to travel during the month of September, then book flights to South America from Pittsburgh during February instead. Flights to South America in February, while not as cheap as those in September, still average around $677.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from Pittsburgh when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $762 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Pittsburgh for as low as $653 on momondo.

Cheap Pittsburgh to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Pittsburgh to South America

Fastest flight time

7h 13m

Direct flights

None
The fastest flight from Pittsburgh to South America takes 7h 13m
There are no direct flights from Pittsburgh to South America. There are no popular flight routes from Pittsburgh to South America.
Search flight deals

  • When did momondo last update prices for flights from Pittsburgh Airport to South America?

    Prices for flights from Pittsburgh Airport to South America refresh daily.

  • How many operators does momondo search for flights from Pittsburgh Airport to South America?

  • How old do you have to be to fly from Pittsburgh Airport to South America?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Pittsburgh Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The required travel and health documents for your South America trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South America. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Pittsburgh to South America

Compare and see reviews for airlines that fly from Pittsburgh to South America with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $265Free CancellationRating
6.3
8,380 reviews
Search Spirit Airlines flights
JetBluePriceFrom $333Free CancellationRating
7.2
2,895 reviews
Search JetBlue flights
American AirlinesPriceFrom $458Free CancellationRating
7.2
11,190 reviews
Search American Airlines flights
DeltaPriceFrom $501Free CancellationRating
7.9
8,115 reviews
Search Delta flights
LATAM AirlinesPriceFrom $575Free CancellationRating
7.5
1,913 reviews
Search LATAM Airlines flights
Copa AirlinesPriceFrom $712Free CancellationRating
7.6
1,558 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $798Free CancellationRating
7.4
9,199 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Pittsburgh to South America?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Pittsburgh to South America. momondo saves you time and could save you money on your trip.

Can I find flights from Pittsburgh to South America with flexible booking policies on momondo?

All flight searches from Pittsburgh to South America on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Pittsburgh to South America?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Pittsburgh to South America.

I’m not ready to book a flight from Pittsburgh to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Pittsburgh to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.

An easier way to manage your South America trip

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Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo
Flights to Limafrom $239
Flights to Buenos Airesfrom $475
Flights to Sao Paulofrom $378
Flights to Bogotáfrom $162
Flights to Rio de Janeirofrom $487
Flights to Medellínfrom $168
Flights to Santiagofrom $357
Flights to Cartagenafrom $139
Flights to Quitofrom $278
Flights to Cuscofrom $413
Flights to Guayaquilfrom $54
Flights to Califrom $203