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Cheap flights from Panama to St. Louis from $317

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama to St. Louis departing on 1/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Panama to St. Louis

Recent round-trip flight deals from Panama to St. Louis

Enter your travel dates to find the best prices.
United Airlines Logo
4:41 pm - 11:02 am
PTY
-
STL
19h 21m2 stops
United Airlines Logo
10:07 am - 7:38 pm
STL
-
PTY
8h 31m1 stop
$572United Airlines
Fri, Jan 23 - Tue, Jan 27
United Airlines Logo
4:41 pm - 12:27 pm
PTY
-
STL
20h 46m2 stops
United Airlines Logo
6:40 pm - 5:07 pm
STL
-
PTY
21h 27m2 stops
$580United Airlines
Mon, Dec 29 - Mon, Jan 12
United Airlines Logo
4:41 pm - 3:39 pm
PTY
-
STL
23h 58m1 stop
United Airlines Logo
6:00 am - 5:07 pm
STL
-
PTY
10h 07m1 stop
$586United Airlines
Fri, Jan 23 - Tue, Jan 27
United Airlines Logo
4:41 pm - 12:29 pm
PTY
-
STL
20h 48m2 stops
United Airlines Logo
6:00 am - 5:07 pm
STL
-
PTY
10h 07m1 stop
$593United Airlines
Fri, Jan 23 - Tue, Jan 27
United Airlines Logo
4:41 pm - 9:55 pm
PTY
-
STL
30h 14m1 stop
United Airlines Logo
4:42 pm - 5:07 pm
STL
-
PTY
23h 25m1 stop
$601United Airlines
Mon, Dec 29 - Sat, Jan 10
United Airlines Logo
4:41 pm - 3:39 pm
PTY
-
STL
23h 58m1 stop
United Airlines Logo
6:00 am - 5:07 pm
STL
-
PTY
10h 07m1 stop
$608United Airlines
Fri, Jan 23 - Tue, Jan 27
American Airlines Logo
2:53 pm - 10:35 pm
PTY
-
STL
8h 42m1 stop
American Airlines Logo
5:07 pm - 3:38 pm
STL
-
PTY
21h 31m1 stop
$644American Airlines
Mon, Dec 29 - Sat, Jan 10
American Airlines Logo
4:55 pm - 1:14 pm
PTY
-
STL
21h 19m2 stops
American Airlines Logo
6:43 pm - 3:38 pm
STL
-
PTY
19h 55m2 stops
$649American Airlines
Mon, Dec 29 - Sat, Jan 10
Multiple Airlines Logo
9:45 am - 10:56 am
PTY
-
STL
26h 11m3 stops
Multiple Airlines Logo
4:05 pm - 10:30 am
STL
-
PTY
17h 25m3 stops
$1,456Multiple Airlines
Mon, Dec 29 - Mon, Jan 12
Multiple Airlines Logo
5:50 pm - 10:56 am
PTY
-
STL
18h 06m2 stops
Multiple Airlines Logo
4:05 pm - 10:30 am
STL
-
PTY
17h 25m3 stops
$1,590Multiple Airlines
Mon, Dec 29 - Mon, Jan 12

American Airlines flights from Panama to St. Louis

Our best American Airlines deals on Panama to St. Louis flight tickets
American Airlines
Dec 29
PTY2:53 pmPanama City Tocumen Intl
8h 42m
1 stop
STL10:35 pmLambert-St Louis
Jan 10
STL5:07 pmLambert-St Louis
21h 31m
1 stop
PTY3:38 pmPanama City Tocumen Intl
$644
Find similar
American Airlines
Dec 29
PTY4:55 pmPanama City Tocumen Intl
21h 19m
2 stops
STL1:14 pmLambert-St Louis
Jan 10
STL6:43 pmLambert-St Louis
19h 55m
2 stops
PTY3:38 pmPanama City Tocumen Intl
$649
Find similar

United Airlines flights from Panama to St. Louis

Our best United Airlines deals on Panama to St. Louis flight tickets
United Airlines
Jan 23
PTY4:41 pmPanama City Tocumen Intl
19h 21m
2 stops
STL11:02 amLambert-St Louis
Jan 27
STL10:07 amLambert-St Louis
8h 31m
1 stop
PTY7:38 pmPanama City Tocumen Intl
$572
Find similar
United Airlines
Dec 29
PTY4:41 pmPanama City Tocumen Intl
20h 46m
2 stops
STL12:27 pmLambert-St Louis
Jan 12
STL6:40 pmLambert-St Louis
21h 27m
2 stops
PTY5:07 pmPanama City Tocumen Intl
$580
Find similar
United Airlines
Jan 23
PTY4:41 pmPanama City Tocumen Intl
23h 58m
1 stop
STL3:39 pmLambert-St Louis
Jan 27
STL6:00 amLambert-St Louis
10h 07m
1 stop
PTY5:07 pmPanama City Tocumen Intl
$586
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 11, 2025.
Use the filters below to find and compare flights from Panama to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Fri 1/23

4:41 pm-11:02 am

2 stops19h 21m

Lambert-St Louis

Tue 1/27

10:07 am-7:38 pm

1 stop8h 31m

$572

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 12/29

4:41 pm-12:27 pm

2 stops20h 46m

Lambert-St Louis

Mon 1/12

6:40 pm-5:07 pm

2 stops21h 27m

$580

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Fri 1/23

4:41 pm-3:39 pm

1 stop23h 58m

Lambert-St Louis

Tue 1/27

6:00 am-5:07 pm

1 stop10h 07m

$586

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Fri 1/23

4:41 pm-12:29 pm

2 stops20h 48m

Lambert-St Louis

Tue 1/27

6:00 am-5:07 pm

1 stop10h 07m

$593

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 12/29

4:41 pm-9:55 pm

1 stop30h 14m

Lambert-St Louis

Sat 1/10

4:42 pm-5:07 pm

1 stop23h 25m

$601

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Fri 1/23

4:41 pm-3:39 pm

1 stop23h 58m

Lambert-St Louis

Tue 1/27

6:00 am-5:07 pm

1 stop10h 07m

$608

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 12/29

2:53 pm-10:35 pm

1 stop8h 42m

Lambert-St Louis

Sat 1/10

5:07 pm-3:38 pm

1 stop21h 31m

$644

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 12/29

4:55 pm-1:14 pm

2 stops21h 19m

Lambert-St Louis

Sat 1/10

6:43 pm-3:38 pm

2 stops19h 55m

$649

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 12/29

9:45 am-10:56 am

3 stops26h 11m

Lambert-St Louis

Mon 1/12

4:05 pm-10:30 am

3 stops17h 25m

$1,456

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 12/29

5:50 pm-10:56 am

2 stops18h 06m

Lambert-St Louis

Mon 1/12

4:05 pm-10:30 am

3 stops17h 25m

$1,590

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Panama to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, June is the cheapest month to fly from Panama to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $362. The month of February is another great option to travel to St. Louis, with average flight prices from Panama averaging around $398.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $496. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Wednesday because tickets tend to average around $611. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Panama at noon is the least expensive time of day to depart. momondo users have found prices as low as $535 when looking at flights departing at noon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $574 per ticket.

Cheap Panama to St. Louis flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama to St. Louis

Fastest flight time

20h 48m

Direct flights

None
The fastest flight from Panama to St. Louis takes 20h 48m
There are no direct flights from Panama to St. Louis. There are no popular flight routes from Panama to St. Louis.
Search flight deals

  • When did momondo last update prices for flights from Panama to Lambert-St Louis Airport?

    Prices for flights from Panama to Lambert-St Louis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Panama to Lambert-St Louis Airport?

  • How old do you have to be to fly from Panama to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The necessary travel and health documents for your Lambert-St Louis Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Panama to St. Louis

Compare and see reviews for airlines that fly from Panama to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $478Free CancellationRating
7.4
9,095 reviews
Search United Airlines flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
Fenton
Wentzville
St. Peters
Collinsville
Alton
Farmington
Festus
Clayton
Glencoe
Edwardsville
Eureka
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Panama to St. Louis?

It is quick and easy to find Panama to St. Louis flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to St. Louis that suits you.

Can I find flights from Panama to St. Louis with flexible booking policies on momondo?

momondo does allow users to show only those flights to St. Louis from Panama which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama to St. Louis?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Panama to St. Louis.

I’m not ready to book a flight from Panama to St. Louis right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Panama to St. Louis flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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