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Cheap flights from Panama to Chicago from $237

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama to Chicago departing on 9/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama to Chicago

Recent round-trip flight deals from Panama to Chicago

Logo
5:25 pm - 10:48 pmPTY-ORD
29h 23m2 stops
Logo
6:05 pm - 9:10 pmORD-PTY
27h 05m3 stops
$436
Find Deal
Mon, Sep 8 - Mon, Sep 15
Logo
9:33 pm - 9:18 amPTY-ORD
11h 45m1 stop
Logo
10:27 am - 7:29 pmORD-PTY
9h 02m1 stop
$445
Find Deal
Mon, Sep 8 - Thu, Sep 18
United Airlines Logo
9:45 am - 11:30 pmPTY-ORD
13h 45m1 stop
United Airlines Logo
6:00 am - 6:37 pmORD-PTY
12h 37m1 stop
$494United Airlines
Find Deal
Fri, Oct 3 - Fri, Oct 10
Copa Airlines Logo
7:20 pm - 1:05 amPTY-ORD
5h 45mnonstop
Copa Airlines Logo
2:07 pm - 8:35 pmORD-PTY
5h 28mnonstop
$495Copa Airlines
Find Deal
Sat, Nov 1 - Thu, Nov 6
Delta Logo
2:21 pm - 10:14 pmPTY-MDW
7h 53m1 stop
Delta Logo
6:00 am - 12:56 pmMDW-PTY
6h 56m1 stop
$500Delta
Find Deal
Tue, Oct 14 - Fri, Oct 24
Delta Logo
2:05 pm - 10:20 amPTY-ORD
20h 15m2 stops
Delta Logo
5:30 am - 12:55 pmORD-PTY
7h 25m1 stop
$500Delta
Find Deal
Sat, Sep 6 - Fri, Sep 12
United Airlines Logo
3:30 pm - 9:21 amPTY-ORD
17h 51m1 stop
United Airlines Logo
7:55 pm - 1:45 pmORD-PTY
17h 50m1 stop
$509United Airlines
Find Deal
Mon, Oct 13 - Sat, Oct 25
Copa Airlines Logo
6:45 pm - 12:21 amPTY-ORD
5h 36mnonstop
Copa Airlines Logo
8:02 am - 1:22 pmORD-PTY
5h 20mnonstop
$511Copa Airlines
Find Deal
Fri, Sep 12 - Sat, Sep 20
Avianca Logo
3:25 am - 1:15 pmPTY-ORD
9h 50m1 stop
Avianca Logo
2:35 pm - 10:10 amORD-PTY
19h 35m1 stop
$531Avianca
Find Deal
Mon, Oct 13 - Tue, Oct 21
Avianca Logo
3:20 am - 1:15 pmPTY-ORD
9h 55m1 stop
Avianca Logo
2:35 pm - 12:45 amORD-PTY
10h 10m1 stop
$535Avianca
Find Deal
Sun, Sep 7 - Mon, Sep 15

American Airlines flights from Panama to Chicago

Our best American Airlines deals on Panama to Chicago flight tickets
American Airlines
Oct 4
PTY3:31 pmPanama City Tocumen Intl
17h 12m
2 stops
ORD8:43 amChicago O'Hare Intl
Oct 11
ORD8:44 pmChicago O'Hare Intl
17h 19m
2 stops
PTY2:03 pmPanama City Tocumen Intl
$512
Find similar
American Airlines
Oct 14
PTY3:15 pmPanama City Tocumen Intl
19h 17m
2 stops
ORD10:32 amChicago O'Hare Intl
Oct 21
ORD8:44 pmChicago O'Hare Intl
17h 19m
2 stops
PTY2:03 pmPanama City Tocumen Intl
$514
Find similar
American Airlines
Oct 9
PTY3:15 pmPanama City Tocumen Intl
8h 43m
1 stop
ORD11:58 pmChicago O'Hare Intl
Oct 16
ORD7:05 pmChicago O'Hare Intl
18h 58m
1 stop
PTY2:03 pmPanama City Tocumen Intl
$521
Find similar

Copa Airlines flights from Panama to Chicago

Our best Copa Airlines deals on Panama to Chicago flight tickets
Copa Airlines
Aug 30
PTY6:45 pmPanama City Tocumen Intl
5h 36m
ORD12:21 amChicago O'Hare Intl
Sep 15
ORD3:07 pmChicago O'Hare Intl
5h 28m
PTY8:35 pmPanama City Tocumen Intl
$495
Find similar
Copa Airlines
Aug 29
PTY6:45 pmPanama City Tocumen Intl
5h 36m
ORD12:21 amChicago O'Hare Intl
Sep 7
ORD8:02 amChicago O'Hare Intl
5h 20m
PTY1:22 pmPanama City Tocumen Intl
$511
Find similar
Copa Airlines
Oct 20
PTY6:45 pmPanama City Tocumen Intl
5h 36m
ORD12:21 amChicago O'Hare Intl
Jan 22
ORD11:51 pmChicago O'Hare Intl
5h 22m
PTY6:13 amPanama City Tocumen Intl
$538
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Panama to Chicago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Mon 9/8

5:25 pm-10:48 pm

2 stops29h 23m

Chicago O'Hare Intl

Mon 9/15

6:05 pm-9:10 pm

3 stops27h 05m

$436

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Mon 9/8

9:33 pm-9:18 am

1 stop11h 45m

Chicago O'Hare Intl

Thu 9/18

10:27 am-7:29 pm

1 stop9h 02m

$445

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Fri 10/3

9:45 am-11:30 pm

1 stop13h 45m

Chicago O'Hare Intl

Fri 10/10

6:00 am-6:37 pm

1 stop12h 37m

$494

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sat 11/1

7:20 pm-1:05 am

Nonstop5h 45m

Chicago O'Hare Intl

Thu 11/6

2:07 pm-8:35 pm

Nonstop5h 28m

$495

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Tue 10/14

2:21 pm-10:14 pm

1 stop7h 53m

Chicago Midway

Fri 10/24

6:00 am-12:56 pm

1 stop6h 56m

$500

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sat 9/6

2:05 pm-10:20 am

2 stops20h 15m

Chicago O'Hare Intl

Fri 9/12

5:30 am-12:55 pm

1 stop7h 25m

$500

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Mon 10/13

3:30 pm-9:21 am

1 stop17h 51m

Chicago O'Hare Intl

Sat 10/25

7:55 pm-1:45 pm

1 stop17h 50m

$509

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Fri 9/12

6:45 pm-12:21 am

Nonstop5h 36m

Chicago O'Hare Intl

Sat 9/20

8:02 am-1:22 pm

Nonstop5h 20m

$511

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Mon 10/13

3:25 am-1:15 pm

1 stop9h 50m

Chicago O'Hare Intl

Tue 10/21

2:35 pm-10:10 am

1 stop19h 35m

$531

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sun 9/7

3:20 am-1:15 pm

1 stop9h 55m

Chicago O'Hare Intl

Mon 9/15

2:35 pm-12:45 am

1 stop10h 10m

$535

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Panama to Chicago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Chicago?

The month of July is, on average, the cheapest month to fly to Chicago from Panama, with most prices found around $423. If you’re not able to fly to Chicago in July, then April is your next best option. Flight prices from Panama to Chicago during April average around $479.

What is the cheapest day to depart on your flight to Chicago?

The cheapest day to depart on your flight to Chicago is on a Wednesday when prices can be found for as low as $529. This is often the case because there is less demand to fly during this day of the week. When flying out on a Tuesday, the most expensive travel day of the week, you can expect to see flight prices from Panama to Chicago for around $1,166.

What is the cheapest time of day to depart on your flight to Chicago?

Our most recent data shows that the best time of day to fly to Chicago is in the afternoon. Flights from Panama to Chicago during this time can be as low as $552. In contrast, the most expensive time of day to depart to Chicago is at noon when prices are around $1,152.

What is the cheapest Panama to Chicago flight route?

Fly from Panama City Tocumen Intl to Chicago O'Hare Intl for the best Panama - Chicago flight prices

How far in advance should I book a flight to Chicago?

You are more likely to see cheaper flights to Chicago from Panama when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago for around $559 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago from Panama for as low as $478 on momondo.

What cabin class options are available on Panama to Chicago flights?

There are 3 cabin classes available to choose from on Panama to Chicago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Cheap Panama to Chicago flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama to Chicago

Best Price Found

$263

Fastest flight time

5h 36m

Direct flights

Every day

Airports in Chicago

1 airport
The best one-way flight to Chicago from Panama in the past 72 hours is $263. The best round-trip flight deal from Panama to Chicago found on momondo in the last 72 hours is $465.
The fastest flight from Panama to Chicago takes 5h 36m
Direct flights go from Panama to Chicago every day.
There is 1 airport near Chicago: Chicago O'Hare Intl (ORD)
Search flight deals

  • When did momondo last update prices for flights from Panama to Chicago?

    Prices for flights from Panama to Chicago were last updated today.

  • How many operators does momondo search for flights from Panama to Chicago?

  • How old do you have to be to fly from Panama to Chicago?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama to Chicago.

  • What documentation or ID do you need to fly to Chicago?

    The required travel and health documents for your Chicago trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Chicago. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Panama to Chicago?

Best airlines flying from Panama to Chicago

Compare and see reviews for airlines that fly from Panama to Chicago with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $415Free CancellationRating
7.5
1,510 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $485Free CancellationRating
7.4
8,928 reviews
Search United Airlines flights
DeltaPriceFrom $569Free CancellationRating
7.9
7,982 reviews
Search Delta flights

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Benton Harbor
Saint Joseph
Lansing
Portage
Schererville
Valparaiso
Crown Point
Munster
Chesterton
Monticello
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Panama to Chicago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Chicago from Panama.

Can I find flights from Panama to Chicago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Chicago from Panama which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama to Chicago?

Once you have performed a search for Panama to Chicago flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama to Chicago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama to Chicago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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Find better results for your trip to the United States

Fly into one of these airports located in Chicago

Airports listed have a maximum distance of 78.5 mi from Chicago
Chicago Midway Airport
Chicago O'Hare Intl Airport
Chicago Greater Rockford Airport