Cheap flights from Panama to Chicago from $176

The month of April is, on average, the cheapest month to fly to Chicago from Panama, with most prices found around $405. If you’re not able to fly to Chicago in April, then July is your next best option. Flight prices from Panama to Chicago during July average around $405.

The cheapest day to depart on your flight to Chicago is on a Wednesday when prices can be found for as low as $479. This is often the case because there is less demand to fly during this day of the week. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Panama to Chicago for around $917.

Our most recent data shows that the best time of day to fly to Chicago is in the afternoon. Flights from Panama to Chicago during this time can be as low as $528. In contrast, the most expensive time of day to depart to Chicago is in the morning when prices are around $711.

Fly from Panama City Tocumen Intl to Chicago O'Hare Intl for the best Panama - Chicago flight prices

You are more likely to see cheaper flights to Chicago from Panama when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago for around $566 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago from Panama for as low as $463 on momondo.

There are 2 cabin classes available to choose from on Panama to Chicago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

The number of flights available between Panama and Chicago is 4 per day as of February 2026. The most frequent departure time is 7:00PM, with 57% of daily flights leaving in the evening.

As of February 2026, 30 flights take off from Panama and land in Chicago each week. The most common flight departure day for this route is Mon, with 17% of weekly flights taking off on this day.