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Cheap flights from Panama to Chicago from $278

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama to Chicago departing on 1/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama to Chicago

Recent round-trip flight deals from Panama to Chicago

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:34 pm - 8:18 am
PTY
-
ORD
14h 44m1 stop
Multiple Airlines Logo
9:23 am - 7:20 pm
ORD
-
PTY
8h 57m1 stop
$370Multiple Airlines
Sat, Jan 17 - Wed, Jan 21
Multiple Airlines Logo
9:33 pm - 8:18 am
PTY
-
ORD
11h 45m1 stop
Multiple Airlines Logo
9:23 am - 8:37 pm
ORD
-
PTY
10h 14m1 stop
$373Multiple Airlines
Tue, Jan 20 - Wed, Jan 28
Multiple Airlines Logo
9:33 pm - 8:18 am
PTY
-
ORD
11h 45m1 stop
Multiple Airlines Logo
6:57 pm - 8:06 am
ORD
-
PTY
12h 09m1 stop
$421Multiple Airlines
Tue, Jan 20 - Thu, Jan 29
Multiple Airlines Logo
10:25 am - 6:16 pm
PTY
-
ORD
8h 51m1 stop
Multiple Airlines Logo
9:23 am - 8:37 pm
ORD
-
PTY
10h 14m1 stop
$468Multiple Airlines
Thu, Jan 22 - Wed, Jan 28
Multiple Airlines Logo
9:33 pm - 9:38 am
PTY
-
ORD
13h 05m1 stop
Multiple Airlines Logo
7:00 am - 7:20 pm
ORD
-
PTY
12h 20m1 stop
$488Multiple Airlines
Sun, Mar 1 - Sun, Mar 22
Multiple Airlines Logo
5:50 pm - 8:18 am
PTY
-
ORD
15h 28m2 stops
Multiple Airlines Logo
4:10 pm - 10:30 am
ORD
-
PTY
17h 20m1 stop
$525Multiple Airlines
Tue, Jan 20 - Thu, Jan 29
Avianca Logo
9:45 am - 8:20 pm
PTY
-
ORD
11h 35m1 stop
Avianca Logo
10:20 pm - 4:55 pm
ORD
-
PTY
17h 35m1 stop
$555Avianca
Wed, Jan 14 - Sun, Jan 25
Delta Logo
3:20 pm - 8:52 am
PTY
-
MDW
18h 32m2 stops
Delta Logo
1:26 pm - 1:55 pm
MDW
-
PTY
23h 29m2 stops
$680Delta
Wed, Jan 21 - Wed, Jan 28
Delta Logo
3:20 pm - 10:22 pm
PTY
-
MDW
8h 02m1 stop
Delta Logo
6:00 am - 1:55 pm
MDW
-
PTY
6h 55m1 stop
$728Delta
Tue, Jan 20 - Tue, Jan 27
Delta Logo
3:20 pm - 10:07 pm
PTY
-
MDW
7h 47m1 stop
Delta Logo
6:00 am - 1:55 pm
MDW
-
PTY
6h 55m1 stop
$771Delta
Fri, Jan 16 - Tue, Jan 20

American Airlines flights from Panama to Chicago

Our best American Airlines deals on Panama to Chicago flight tickets
American Airlines
May 2
PTY1:55 pmPanama City Tocumen Intl
17h 15m
2 stops
ORD7:10 amChicago O'Hare Intl
May 10
ORD5:00 amChicago O'Hare Intl
7h 15m
1 stop
PTY12:15 pmPanama City Tocumen Intl
$599
Find similar
American Airlines
Mar 31
PTY3:13 pmPanama City Tocumen Intl
20h 52m
1 stop
ORD12:05 pmChicago O'Hare Intl
Apr 9
ORD7:17 pmChicago O'Hare Intl
16h 58m
1 stop
PTY12:15 pmPanama City Tocumen Intl
$604
Find similar
American Airlines
Mar 31
PTY3:13 pmPanama City Tocumen Intl
16h 08m
2 stops
ORD7:21 amChicago O'Hare Intl
Apr 9
ORD8:32 pmChicago O'Hare Intl
15h 43m
2 stops
PTY12:15 pmPanama City Tocumen Intl
$609
Find similar

Avianca flights from Panama to Chicago

Our best Avianca deals on Panama to Chicago flight tickets
Avianca
Jan 13
PTY2:55 amPanama City Tocumen Intl
18h 25m
1 stop
ORD8:20 pmChicago O'Hare Intl
Jan 25
ORD10:20 pmChicago O'Hare Intl
17h 35m
1 stop
PTY4:55 pmPanama City Tocumen Intl
$555
Find similar
Avianca
Dec 17
PTY2:55 amPanama City Tocumen Intl
18h 25m
1 stop
ORD8:20 pmChicago O'Hare Intl
Dec 30
ORD4:10 pmChicago O'Hare Intl
17h 20m
1 stop
PTY10:30 amPanama City Tocumen Intl
$561
Find similar
Avianca
May 1
PTY10:05 pmPanama City Tocumen Intl
15h 10m
1 stop
ORD1:15 pmChicago O'Hare Intl
May 12
ORD2:35 pmChicago O'Hare Intl
9h 35m
1 stop
PTY12:10 amPanama City Tocumen Intl
$571
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Panama to Chicago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sat 1/17

6:34 pm-8:18 am

1 stop14h 44m

Chicago O'Hare Intl

Wed 1/21

9:23 am-7:20 pm

1 stop8h 57m

$370

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Tue 1/20

9:33 pm-8:18 am

1 stop11h 45m

Chicago O'Hare Intl

Wed 1/28

9:23 am-8:37 pm

1 stop10h 14m

$373

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Tue 1/20

9:33 pm-8:18 am

1 stop11h 45m

Chicago O'Hare Intl

Thu 1/29

6:57 pm-8:06 am

1 stop12h 09m

$421

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Thu 1/22

10:25 am-6:16 pm

1 stop8h 51m

Chicago O'Hare Intl

Wed 1/28

9:23 am-8:37 pm

1 stop10h 14m

$468

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sun 3/1

9:33 pm-9:38 am

1 stop13h 05m

Chicago O'Hare Intl

Sun 3/22

7:00 am-7:20 pm

1 stop12h 20m

$488

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Tue 1/20

5:50 pm-8:18 am

2 stops15h 28m

Chicago O'Hare Intl

Thu 1/29

4:10 pm-10:30 am

1 stop17h 20m

$525

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Wed 1/14

9:45 am-8:20 pm

1 stop11h 35m

Chicago O'Hare Intl

Sun 1/25

10:20 pm-4:55 pm

1 stop17h 35m

$555

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Wed 1/21

3:20 pm-8:52 am

2 stops18h 32m

Chicago Midway

Wed 1/28

1:26 pm-1:55 pm

2 stops23h 29m

$680

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Tue 1/20

3:20 pm-10:22 pm

1 stop8h 02m

Chicago Midway

Tue 1/27

6:00 am-1:55 pm

1 stop6h 55m

$728

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Fri 1/16

3:20 pm-10:07 pm

1 stop7h 47m

Chicago Midway

Tue 1/20

6:00 am-1:55 pm

1 stop6h 55m

$771

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Panama to Chicago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Chicago?

The month of July is, on average, the cheapest month to fly to Chicago from Panama, with most prices found around $423. If you’re not able to fly to Chicago in July, then November is your next best option. Flight prices from Panama to Chicago during November average around $459.

What is the cheapest day to depart on your flight to Chicago?

The cheapest day to depart on your flight to Chicago is on a Wednesday when prices can be found for as low as $479. This is often the case because there is less demand to fly during this day of the week. When flying out on a Tuesday, the most expensive travel day of the week, you can expect to see flight prices from Panama to Chicago for around $799.

What is the cheapest time of day to depart on your flight to Chicago?

Our most recent data shows that the best time of day to fly to Chicago is in the afternoon. Flights from Panama to Chicago during this time can be as low as $528. In contrast, the most expensive time of day to depart to Chicago is at noon when prices are around $1,152.

What is the cheapest Panama to Chicago flight route?

Fly from Panama City Tocumen Intl to Chicago O'Hare Intl for the best Panama - Chicago flight prices

How far in advance should I book a flight to Chicago?

You are more likely to see cheaper flights to Chicago from Panama when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago for around $568 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago from Panama for as low as $463 on momondo.

What cabin class options are available on Panama to Chicago flights?

There are 2 cabin classes available to choose from on Panama to Chicago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama to Chicago flights?

No. A direct flight is the cheapest option for a flight between Panama to Chicago.

Cheap Panama to Chicago flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama to Chicago

Best Price Found

$565

Fastest flight time

5h 36m

Direct flights

Every day

Airports in Chicago

3 airports
The best one-way flight to Chicago from Panama in the past 72 hours is $565. The best round-trip flight deal from Panama to Chicago found on momondo in the last 72 hours is $597.
The fastest flight from Panama to Chicago takes 5h 36m
Direct flights go from Panama to Chicago every day.
There are 3 airports in Chicago. From Panama there are direct flights to Chicago O'Hare Intl (ORD).
Search flight deals

  • When did momondo last update prices for flights from Panama to Chicago?

    Prices for flights from Panama to Chicago were last updated today.

  • How many operators does momondo search for flights from Panama to Chicago?

  • How old do you have to be to fly from Panama to Chicago?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama to Chicago.

  • What documentation or ID do you need to fly to Chicago?

    The required travel and health documents for your Chicago trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Chicago. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Panama to Chicago?

Best airlines flying from Panama to Chicago

Compare and see reviews for airlines that fly from Panama to Chicago with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $405Free CancellationRating
7.6
1,557 reviews
Search Copa Airlines flights
United AirlinesPriceFrom $423Free CancellationRating
7.4
9,092 reviews
Search United Airlines flights

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Benton Harbor
Saint Joseph
Portage
Lansing
Valparaiso
Schererville
Crown Point
Munster
Chesterton
Monticello
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Panama to Chicago?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Chicago from Panama.

Can I find flights from Panama to Chicago with flexible booking policies on momondo?

momondo does allow users to show only those flights to Chicago from Panama which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Panama to Chicago?

Once you have performed a search for Panama to Chicago flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama to Chicago right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Panama to Chicago flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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Find better results for your trip to the United States

Fly into one of these airports located in Chicago

Airports listed have a maximum distance of 78.5 mi from Chicago
Chicago Midway Airport
Chicago O'Hare Intl Airport
Chicago Greater Rockford Airport