What is the cheapest airline that flies from Panama City Tocumen Intl to South Carolina?

United Airlines, American Airlines, and Delta are the most popular carriers operating from Panama City Tocumen Intl to South Carolina

When did momondo last update prices for flights from Panama City Tocumen Intl Airport to South Carolina?

Prices for flights from Panama City Tocumen Intl Airport to South Carolina are refreshed on a daily basis.

How many operators does momondo search for flights from Panama City Tocumen Intl Airport to South Carolina?

The number of operators available for flights from Panama City Tocumen Intl Airport to South Carolina is 2 as of September 2026.

How old do you have to be to fly from Panama City Tocumen Intl Airport to South Carolina?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$330 Cheap Flights from Panama City to South Carolina in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Panama City to South Carolina

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

10:10 am - 1:55 pmPTY Panama City Tocumen Intl-CLT Charlotte Douglas

26h 45m2 stops Bogotá El Dorado Miami

9:59 pm - 2:15 pmCLT Charlotte Douglas-PTY Panama City Tocumen Intl

17h 16m2 stops Miami Bogotá El Dorado

$591Multiple Airlines

Tue, Sep 29 - Tue, Oct 6

9:30 am - 11:00 pmPTY Panama City Tocumen Intl-GSP Greenville

12h 30m1 stop Newark

6:20 am - 7:38 pmGSP Greenville-PTY Panama City Tocumen Intl

13h 18m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

$594United Airlines

Wed, Oct 28 - Tue, Nov 3

3:24 pm - 6:57 pmPTY Panama City Tocumen Intl-GSP Greenville

27h 33m1 stop Atlanta Hartsfield-Jackson

7:00 am - 1:59 pmGSP Greenville-PTY Panama City Tocumen Intl

6h 59m1 stop Atlanta Hartsfield-Jackson

$594Delta

Mon, Nov 2 - Thu, Nov 5

2:24 pm - 10:51 pmPTY Panama City Tocumen Intl-GSP Greenville

7h 27m1 stop Atlanta Hartsfield-Jackson

8:05 am - 1:59 pmGSP Greenville-PTY Panama City Tocumen Intl

5h 54m1 stop Atlanta Hartsfield-Jackson

$594Delta

Wed, Oct 28 - Tue, Nov 3

7:55 am - 8:58 pmPTY Panama City Tocumen Intl-GSP Greenville

12h 03m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

6:20 am - 7:38 pmGSP Greenville-PTY Panama City Tocumen Intl

13h 18m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

$594United Airlines

Wed, Oct 28 - Tue, Nov 3

2:24 pm - 1:00 pmPTY Panama City Tocumen Intl-GSP Greenville

21h 36m1 stop Atlanta Hartsfield-Jackson

7:14 pm - 2:02 pmGSP Greenville-PTY Panama City Tocumen Intl

18h 48m1 stop Atlanta Hartsfield-Jackson

$594Delta

Wed, Oct 28 - Sun, Nov 8

9:45 am - 9:44 amPTY Panama City Tocumen Intl-CLT Charlotte Douglas

22h 59m2 stops Newark Washington, D.C. Dulles Intl

6:00 am - 7:02 pmCLT Charlotte Douglas-PTY Panama City Tocumen Intl

14h 02m2 stops Washington, D.C. Dulles Intl Newark

$626United Airlines

Thu, Oct 22 - Sun, Oct 25

3:13 pm - 10:25 amPTY Panama City Tocumen Intl-CHS Charleston

19h 12m2 stops Miami Charlotte Douglas

8:14 pm - 2:13 pmCHS Charleston-PTY Panama City Tocumen Intl

17h 59m1 stop Miami

$639American Airlines

Wed, Nov 4 - Mon, Nov 9

3:13 pm - 8:31 amPTY Panama City Tocumen Intl-CHS Charleston

17h 18m2 stops Miami Charlotte Douglas

4:13 pm - 2:13 pmCHS Charleston-PTY Panama City Tocumen Intl

22h 00m2 stops Washington, D.C. Reagan-National Miami

$647American Airlines

Wed, Nov 4 - Mon, Nov 9

2:02 pm - 11:59 pmPTY Panama City Tocumen Intl-CHS Charleston

8h 57m1 stop Miami

6:00 am - 1:02 pmCHS Charleston-PTY Panama City Tocumen Intl

8h 02m1 stop Miami

$650American Airlines

Wed, Oct 14 - Fri, Oct 23

Cheap last minute flights

Enter your travel dates to find the best prices.

3:30 pm - 4:06 pmPTY Panama City Tocumen Intl-CLT Charlotte Douglas

23h 36m1 stop Houston George Bush Intcntl

6:00 am - 7:02 pmCLT Charlotte Douglas-PTY Panama City Tocumen Intl

14h 02m1 stop Newark

$648United Airlines

Wed, Sep 9 - Wed, Oct 28

3:30 pm - 10:24 amPTY Panama City Tocumen Intl-CLT Charlotte Douglas

17h 54m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

5:33 pm - 8:02 pmCLT Charlotte Douglas-PTY Panama City Tocumen Intl

26h 29m2 stops Chicago O'Hare Intl Newark

$648United Airlines

Wed, Sep 9 - Tue, Nov 3

3:30 pm - 2:02 pmPTY Panama City Tocumen Intl-CLT Charlotte Douglas

21h 32m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

7:55 pm - 8:02 pmCLT Charlotte Douglas-PTY Panama City Tocumen Intl

24h 07m2 stops Washington, D.C. Dulles Intl Newark

$648United Airlines

Wed, Sep 9 - Tue, Nov 10

3:30 pm - 10:54 amPTY Panama City Tocumen Intl-CLT Charlotte Douglas

18h 24m1 stop Houston George Bush Intcntl

6:40 am - 7:38 pmCLT Charlotte Douglas-PTY Panama City Tocumen Intl

12h 58m1 stop Houston George Bush Intcntl

$648United Airlines

Wed, Sep 9 - Tue, Nov 3

5:55 pm - 1:55 pmPTY Panama City Tocumen Intl-CLT Charlotte Douglas

19h 00m2 stops Bogotá El Dorado Miami

9:41 pm - 1:20 amCLT Charlotte Douglas-PTY Panama City Tocumen Intl

27h 39m2 stops Miami Bogotá El Dorado

$667Multiple Airlines

Wed, Sep 9 - Mon, Nov 2

1:39 pm - 10:59 amPTY Panama City Tocumen Intl-CLT Charlotte Douglas

20h 20m1 stop Miami

4:42 pm - 1:02 pmCLT Charlotte Douglas-PTY Panama City Tocumen Intl

21h 20m1 stop Miami

$668American Airlines

Tue, Sep 8 - Thu, Oct 29

1:16 pm - 10:20 amPTY Panama City Tocumen Intl-CLT Charlotte Douglas

20h 04m1 stop Miami

10:25 pm - 2:13 pmCLT Charlotte Douglas-PTY Panama City Tocumen Intl

15h 48m1 stop Miami

$668American Airlines

Wed, Sep 9 - Mon, Nov 2

10:10 am - 1:55 pmPTY Panama City Tocumen Intl-CLT Charlotte Douglas

26h 45m2 stops Bogotá El Dorado Miami

9:41 pm - 2:10 amCLT Charlotte Douglas-PTY Panama City Tocumen Intl

28h 29m3 stops Miami Managua Augusto C Sandino San Salvador El Salvador Intl

$669Multiple Airlines

Wed, Sep 9 - Mon, Nov 2

1:39 pm - 7:50 amPTY Panama City Tocumen Intl-CLT Charlotte Douglas

17h 11m2 stops Miami Washington, D.C. Reagan-National

4:42 pm - 1:02 pmCLT Charlotte Douglas-PTY Panama City Tocumen Intl

21h 20m1 stop Miami

$673American Airlines

Tue, Sep 8 - Thu, Oct 29

5:55 pm - 1:55 pmPTY Panama City Tocumen Intl-CLT Charlotte Douglas

19h 00m2 stops Bogotá El Dorado Miami

9:59 pm - 12:35 amCLT Charlotte Douglas-PTY Panama City Tocumen Intl

27h 36m2 stops Miami Bogotá El Dorado

$716Multiple Airlines

Wed, Sep 9 - Mon, Sep 14

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United Airlines flights from Panama City to South Carolina

Our best United Airlines deals on Panama City to South Carolina flight tickets

United Airlines

Nov 12

PTY10:00 amPanama City Tocumen Intl

13h 00m

1 stop

GSP11:00 pmGreenville

Nov 16

GSP5:37 pmGreenville

21h 08m

2 stops

PTY2:45 pmPanama City Tocumen Intl

$607

United Airlines

Nov 12

PTY8:55 amPanama City Tocumen Intl

24h 35m

2 stops

GSP9:30 amGreenville

Nov 16

GSP7:43 pmGreenville

24h 19m

2 stops

PTY8:02 pmPanama City Tocumen Intl

$629

United Airlines

Sep 9

PTY3:30 pmPanama City Tocumen Intl

21h 32m

2 stops

CLT2:02 pmCharlotte Douglas

Nov 3

CLT6:40 amCharlotte Douglas

12h 58m

1 stop

PTY7:38 pmPanama City Tocumen Intl

$648

Avianca flights from Panama City to South Carolina

Our best Avianca deals on Panama City to South Carolina flight tickets

Avianca

Sep 10

PTY5:30 amPanama City Tocumen Intl

12h 26m

2 stops

CLT6:56 pmCharlotte Douglas

Oct 14

CLT10:25 amCharlotte Douglas

16h 30m

2 stops

PTY1:55 amPanama City Tocumen Intl

$877

Avianca

Oct 2

PTY3:50 pmPanama City Tocumen Intl

26h 10m

2 stops

CLT7:00 pmCharlotte Douglas

Oct 10

CLT7:50 pmCharlotte Douglas

20h 05m

3 stops

PTY2:55 pmPanama City Tocumen Intl

$920

Avianca

Sep 29

PTY11:25 amPanama City Tocumen Intl

30h 35m

3 stops

CLT7:00 pmCharlotte Douglas

Oct 6

CLT10:25 amCharlotte Douglas

29h 30m

3 stops

PTY2:55 pmPanama City Tocumen Intl

$929

momondo Fare Finder

Use the filters below to find and compare flights from Panama City to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityCharlotte

PTY Panama City Tocumen Intl - CLT Charlotte Douglas

PTYCLT

Panama City Tocumen Intl

Tue 9/29

10:10 am-1:55 pm

2 stops26h 45m

Charlotte Douglas

Tue 10/6

9:59 pm-2:15 pm

2 stops17h 16m

$591

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Wed 10/28

9:30 am-11:00 pm

1 stop12h 30m

Greenville

Tue 11/3

6:20 am-7:38 pm

2 stops13h 18m

$594

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Mon 11/2

3:24 pm-6:57 pm

1 stop27h 33m

Greenville

Thu 11/5

7:00 am-1:59 pm

1 stop6h 59m

$594

Quickest round-trip

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Wed 10/28

2:24 pm-10:51 pm

1 stop7h 27m

Greenville

Tue 11/3

8:05 am-1:59 pm

1 stop5h 54m

$594

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Wed 10/28

7:55 am-8:58 pm

2 stops12h 03m

Greenville

Tue 11/3

6:20 am-7:38 pm

2 stops13h 18m

$594

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Wed 10/28

2:24 pm-1:00 pm

1 stop21h 36m

Greenville

Sun 11/8

7:14 pm-2:02 pm

1 stop18h 48m

$594

Panama CityCharlotte

PTY Panama City Tocumen Intl - CLT Charlotte Douglas

PTYCLT

Panama City Tocumen Intl

Thu 10/22

9:45 am-9:44 am

2 stops22h 59m

Charlotte Douglas

Sun 10/25

6:00 am-7:02 pm

2 stops14h 02m

$626

Panama CityCharleston

PTY Panama City Tocumen Intl - CHS Charleston

PTYCHS

Panama City Tocumen Intl

Wed 11/4

3:13 pm-10:25 am

2 stops19h 12m

Charleston

Mon 11/9

8:14 pm-2:13 pm

1 stop17h 59m

$639

Panama CityCharleston

PTY Panama City Tocumen Intl - CHS Charleston

PTYCHS

Panama City Tocumen Intl

Wed 11/4

3:13 pm-8:31 am

2 stops17h 18m

Charleston

Mon 11/9

4:13 pm-2:13 pm

2 stops22h 00m

$647

Panama CityCharleston

PTY Panama City Tocumen Intl - CHS Charleston

PTYCHS

Panama City Tocumen Intl

Wed 10/14

2:02 pm-11:59 pm

1 stop8h 57m

Charleston

Fri 10/23

6:00 am-1:02 pm

1 stop8h 02m

$650

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Panama City to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Panama City is in December. Flight prices, which tend to average around $376, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of December, then book flights to South Carolina from Panama City during October instead. Flights to South Carolina in October, while not as cheap as those in December, still average around $392.

Can stopping save me money on Panama City to South Carolina flights?

You could potentially save up to 16% on your flight if you consider stops on a Panama City to South Carolina flight.

Cheap Panama City to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to South Carolina

Best Price Found	$330
Fastest flight time	7h 32m
Direct flights	None

The best one-way flight to South Carolina from Panama City in the past 72 hours is $330. The best round-trip flight deal from Panama City to South Carolina found on momondo in the last 72 hours is $591.

The fastest flight from Panama City to South Carolina takes 7h 32m

There are no direct flights from Panama City to South Carolina. There are no popular flight routes from Panama City to South Carolina.

Search flight deals

Frequently asked questions about flying from Panama City to South Carolina

When did momondo last update prices for flights from Panama City Tocumen Intl Airport to South Carolina?
Prices for flights from Panama City Tocumen Intl Airport to South Carolina are refreshed on a daily basis.
How many operators does momondo search for flights from Panama City Tocumen Intl Airport to South Carolina?
The number of operators available for flights from Panama City Tocumen Intl Airport to South Carolina is 2 as of September 2026.
How old do you have to be to fly from Panama City Tocumen Intl Airport to South Carolina?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Panama City to South Carolina

Compare and see reviews for airlines that fly from Panama City to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $431	Free Cancellation	Rating 7.1 12,030 reviews		Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama City to South Carolina for you.

Can I find flights from Panama City to South Carolina with flexible booking policies on momondo?

All flight searches from Panama City to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to South Carolina?

momondo provides multiple filters to help you find the best flight to South Carolina from Panama City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Panama City to South Carolina right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South Carolina from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.