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Cheap flights from Panama City to South Carolina from $240

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to South Carolina departing on 12/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
9:33 pm - 10:38 am
PTY
-
CLT
13h 05m1 stop
Multiple Airlines Logo
8:38 pm - 8:06 am
CLT
-
PTY
11h 28m1 stop
$369Multiple Airlines
Thu, Jan 29 - Thu, Feb 5
United Airlines Logo
4:41 pm - 9:54 pm
PTY
-
CHS
29h 13m1 stop
United Airlines Logo
5:07 pm - 5:07 pm
CHS
-
PTY
24h 00m1 stop
$377United Airlines
Tue, Feb 3 - Tue, Feb 17
American Airlines Logo
1:50 pm - 10:59 am
PTY
-
CHS
20h 09m2 stops
American Airlines Logo
4:22 pm - 12:25 pm
CHS
-
PTY
21h 03m2 stops
$397American Airlines
Fri, May 29 - Mon, Jun 1
Multiple Airlines Logo
9:33 pm - 12:20 pm
PTY
-
CLT
14h 47m1 stop
Multiple Airlines Logo
7:00 am - 7:20 pm
CLT
-
PTY
13h 20m1 stop
$439Multiple Airlines
Mon, Feb 16 - Tue, Mar 17
Multiple Airlines Logo
2:55 am - 6:48 pm
PTY
-
CLT
15h 53m2 stops
Multiple Airlines Logo
7:00 am - 1:00 am
CLT
-
PTY
18h 00m2 stops
$447Multiple Airlines
Wed, Jan 28 - Thu, Feb 5
American Airlines Logo
1:50 pm - 10:16 am
PTY
-
CHS
19h 26m1 stop
American Airlines Logo
8:02 pm - 12:25 pm
CHS
-
PTY
17h 23m1 stop
$450American Airlines
Fri, May 29 - Mon, Jun 1
Delta Logo
8:00 am - 7:10 pm
PTY
-
CLT
11h 10m1 stop
Delta Logo
5:25 am - 1:55 pm
CLT
-
PTY
8h 30m1 stop
$522Delta
Sat, Dec 27 - Thu, Jan 8
Delta Logo
3:22 pm - 11:46 pm
PTY
-
CLT
8h 24m1 stop
Delta Logo
7:05 am - 8:00 pm
CLT
-
PTY
12h 55m1 stop
$543Delta
Sat, Dec 27 - Sat, Jan 3
WestJet Logo
9:20 am - 7:30 pm
PTY
-
CAE
33h 10m2 stops
WestJet Logo
11:55 am - 8:20 am
CAE
-
PTY
21h 25m2 stops
$1,752WestJet
Tue, Apr 14 - Sat, Apr 18
WestJet Logo
9:20 am - 7:30 pm
PTY
-
CAE
33h 10m2 stops
WestJet Logo
11:55 am - 8:20 am
CAE
-
PTY
21h 25m2 stops
$1,757WestJet
Tue, Apr 14 - Sat, Apr 18

United Airlines flights from Panama City to South Carolina

Our best United Airlines deals on Panama City to South Carolina flight tickets
United Airlines
Feb 3
PTY4:41 pmPanama City Tocumen Intl
29h 13m
1 stop
CHS9:54 pmCharleston
Feb 17
CHS5:07 pmCharleston
24h 00m
1 stop
PTY5:07 pmPanama City Tocumen Intl
$377
Find similar
United Airlines
Dec 20
PTY4:41 pmPanama City Tocumen Intl
29h 01m
1 stop
CLT9:42 pmCharlotte Douglas
Feb 26
CLT6:33 amCharlotte Douglas
10h 34m
1 stop
PTY5:07 pmPanama City Tocumen Intl
$469
Find similar
United Airlines
Dec 29
PTY4:41 pmPanama City Tocumen Intl
29h 01m
1 stop
CLT9:42 pmCharlotte Douglas
Jan 5
CLT11:24 amCharlotte Douglas
29h 43m
1 stop
PTY5:07 pmPanama City Tocumen Intl
$490
Find similar

American Airlines flights from Panama City to South Carolina

Our best American Airlines deals on Panama City to South Carolina flight tickets
American Airlines
May 29
PTY1:50 pmPanama City Tocumen Intl
19h 26m
1 stop
CHS10:16 amCharleston
Jun 1
CHS6:30 pmCharleston
18h 55m
2 stops
PTY12:25 pmPanama City Tocumen Intl
$397
Find similar
American Airlines
May 29
PTY1:50 pmPanama City Tocumen Intl
19h 26m
1 stop
CHS10:16 amCharleston
Jun 1
CHS8:02 pmCharleston
17h 23m
1 stop
PTY12:25 pmPanama City Tocumen Intl
$450
Find similar
American Airlines
Feb 3
PTY2:27 pmPanama City Tocumen Intl
23h 07m
2 stops
CHS1:34 pmCharleston
Feb 17
CHS6:00 amCharleston
7h 50m
1 stop
PTY1:50 pmPanama City Tocumen Intl
$454
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Panama City to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 1/29

9:33 pm-10:38 am

1 stop13h 05m

Charlotte Douglas

Thu 2/5

8:38 pm-8:06 am

1 stop11h 28m

$369

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 2/3

4:41 pm-9:54 pm

1 stop29h 13m

Charleston

Tue 2/17

5:07 pm-5:07 pm

1 stop24h 00m

$377

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 5/29

1:50 pm-10:59 am

2 stops20h 09m

Charleston

Mon 6/1

4:22 pm-12:25 pm

2 stops21h 03m

$397

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Mon 2/16

9:33 pm-12:20 pm

1 stop14h 47m

Charlotte Douglas

Tue 3/17

7:00 am-7:20 pm

1 stop13h 20m

$439

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 1/28

2:55 am-6:48 pm

2 stops15h 53m

Charlotte Douglas

Thu 2/5

7:00 am-1:00 am

2 stops18h 00m

$447

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 5/29

1:50 pm-10:16 am

1 stop19h 26m

Charleston

Mon 6/1

8:02 pm-12:25 pm

1 stop17h 23m

$450

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Sat 12/27

8:00 am-7:10 pm

1 stop11h 10m

Charlotte Douglas

Thu 1/8

5:25 am-1:55 pm

1 stop8h 30m

$522

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Sat 12/27

3:22 pm-11:46 pm

1 stop8h 24m

Charlotte Douglas

Sat 1/3

7:05 am-8:00 pm

1 stop12h 55m

$543

Panama CityColumbia

PTY - CAE

PTYCAE

Panama City Tocumen Intl

Tue 4/14

9:20 am-7:30 pm

2 stops33h 10m

Columbia Metropolitan

Sat 4/18

11:55 am-8:20 am

2 stops21h 25m

$1,752

Panama CityColumbia

PTY - CAE

PTYCAE

Panama City Tocumen Intl

Tue 4/14

9:20 am-7:30 pm

2 stops33h 10m

Columbia Metropolitan

Sat 4/18

11:55 am-8:20 am

2 stops21h 25m

$1,757

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Panama City to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Wednesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $502. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $552.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Panama City to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $469. Try not to purchase tickets in the afternoon because they tend to be around $554. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on Panama City to South Carolina flights?

You could potentially save up to 17% on your flight if you consider stops on a Panama City to South Carolina flight.

Cheap Panama City to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to South Carolina

Fastest flight time

8h 18m

Direct flights

None
The fastest flight from Panama City to South Carolina takes 8h 18m
There are no direct flights from Panama City to South Carolina. There are no popular flight routes from Panama City to South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to South Carolina?

    Prices for flights from Panama City Tocumen Intl Airport to South Carolina are refreshed on a daily basis.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to South Carolina?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to South Carolina?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Panama City to South Carolina

Compare and see reviews for airlines that fly from Panama City to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $205Free CancellationRating
7.9
8,008 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama City to South Carolina for you.

Can I find flights from Panama City to South Carolina with flexible booking policies on momondo?

All flight searches from Panama City to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to South Carolina?

momondo provides multiple filters to help you find the best flight to South Carolina from Panama City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Panama City to South Carolina right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South Carolina from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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