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Cheap flights from Panama City to South Carolina from $221

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to South Carolina departing on 9/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Panama City to South Carolina

Cheap round-trip flights

American Airlines Logo
3:31 pm - 9:42 amPTY-CHS
17h 11m2 stops
American Airlines Logo
5:36 pm - 12:55 pmCHS-PTY
20h 19m2 stops
$390American Airlines
Find Deal
Thu, Sep 11 - Mon, Sep 15
American Airlines Logo
3:31 pm - 11:37 pmPTY-CHS
7h 06m1 stop
American Airlines Logo
7:08 am - 2:31 pmCHS-PTY
8h 23m1 stop
$405American Airlines
Find Deal
Thu, Sep 11 - Mon, Sep 15
United Airlines Logo
10:00 am - 4:44 pmPTY-CHS
29h 44m1 stop
United Airlines Logo
6:00 am - 1:55 pmCHS-PTY
8h 55m1 stop
$415United Airlines
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Fri, Oct 17 - Sat, Nov 1
Logo
5:25 pm - 12:45 pmPTY-CLT
18h 20m2 stops
Logo
10:46 am - 12:10 amCLT-PTY
14h 24m2 stops
$445
Find Deal
Fri, Sep 5 - Sat, Sep 13
Logo
5:25 pm - 12:38 pmPTY-CLT
18h 13m2 stops
Logo
7:00 am - 9:10 pmCLT-PTY
15h 10m2 stops
$450
Find Deal
Wed, Aug 20 - Wed, Aug 27
United Airlines Logo
8:55 am - 9:59 pmPTY-CLT
13h 04m1 stop
United Airlines Logo
6:30 am - 5:07 pmCLT-PTY
10h 37m1 stop
$481United Airlines
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Wed, Dec 3 - Tue, Jan 13
Delta Logo
2:10 pm - 11:37 pmPTY-CAE
8h 27m1 stop
Delta Logo
5:40 am - 12:55 pmCAE-PTY
8h 15m1 stop
$512Delta
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Fri, Sep 26 - Tue, Sep 30
Delta Logo
8:05 am - 3:13 pmPTY-MYR
7h 08m1 stop
Delta Logo
6:00 am - 8:01 pmMYR-PTY
14h 01m1 stop
$907Delta
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Sat, Dec 6 - Sat, Dec 13
Copa Airlines Logo
10:29 pm - 9:49 amPTY-CAE
10h 20m1 stop
Copa Airlines Logo
7:35 pm - 6:13 amCAE-PTY
10h 38m1 stop
$1,346Copa Airlines
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Tue, Aug 26 - Wed, Nov 5
Copa Airlines Logo
10:29 pm - 9:49 amPTY-CAE
10h 20m1 stop
Copa Airlines Logo
10:24 am - 8:34 pmCAE-PTY
11h 10m1 stop
$1,823Copa Airlines
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Mon, Aug 18 - Sat, Sep 6

United Airlines flights from Panama City to South Carolina

Our best United Airlines deals on Panama City to South Carolina flight tickets
United Airlines
Oct 17
PTY10:00 amPanama City Tocumen Intl
29h 44m
1 stop
CHS4:44 pmCharleston
Nov 1
CHS6:00 amCharleston
8h 55m
1 stop
PTY1:55 pmPanama City Tocumen Intl
$415
Find similar
United Airlines
Dec 3
PTY8:55 amPanama City Tocumen Intl
13h 04m
1 stop
CLT9:59 pmCharlotte Douglas
Jan 13
CLT6:30 amCharlotte Douglas
10h 37m
1 stop
PTY5:07 pmPanama City Tocumen Intl
$481
Find similar
United Airlines
Aug 26
PTY3:30 pmPanama City Tocumen Intl
18h 24m
1 stop
CLT10:54 amCharlotte Douglas
Nov 4
CLT6:45 amCharlotte Douglas
12h 53m
1 stop
PTY7:38 pmPanama City Tocumen Intl
$524
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American Airlines flights from Panama City to South Carolina

Our best American Airlines deals on Panama City to South Carolina flight tickets
American Airlines
Sep 11
PTY3:31 pmPanama City Tocumen Intl
17h 11m
2 stops
CHS9:42 amCharleston
Sep 15
CHS5:36 pmCharleston
20h 19m
2 stops
PTY12:55 pmPanama City Tocumen Intl
$390
Find similar
American Airlines
Sep 11
PTY3:31 pmPanama City Tocumen Intl
7h 06m
1 stop
CHS11:37 pmCharleston
Sep 15
CHS7:08 amCharleston
8h 23m
1 stop
PTY2:31 pmPanama City Tocumen Intl
$405
Find similar
American Airlines
Oct 17
PTY3:15 pmPanama City Tocumen Intl
23h 25m
2 stops
CHS3:40 pmCharleston
Nov 1
CHS6:00 amCharleston
9h 03m
1 stop
PTY2:03 pmPanama City Tocumen Intl
$475
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 7, 2025.
Use the filters below to find and compare flights from Panama City to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Thu 9/11

3:31 pm-9:42 am

2 stops17h 11m

Charleston

Mon 9/15

5:36 pm-12:55 pm

2 stops20h 19m

$390

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Thu 9/11

3:31 pm-11:37 pm

1 stop7h 06m

Charleston

Mon 9/15

7:08 am-2:31 pm

1 stop8h 23m

$405

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 10/17

10:00 am-4:44 pm

1 stop29h 44m

Charleston

Sat 11/1

6:00 am-1:55 pm

1 stop8h 55m

$415

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Fri 9/5

5:25 pm-12:45 pm

2 stops18h 20m

Charlotte Douglas

Sat 9/13

10:46 am-12:10 am

2 stops14h 24m

$445

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 8/20

5:25 pm-12:38 pm

2 stops18h 13m

Charlotte Douglas

Wed 8/27

7:00 am-9:10 pm

2 stops15h 10m

$450

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 12/3

8:55 am-9:59 pm

1 stop13h 04m

Charlotte Douglas

Tue 1/13

6:30 am-5:07 pm

1 stop10h 37m

$481

Panama CityColumbia

PTY - CAE

PTYCAE

Panama City Tocumen Intl

Fri 9/26

2:10 pm-11:37 pm

1 stop8h 27m

Columbia Metropolitan

Tue 9/30

5:40 am-12:55 pm

1 stop8h 15m

$512

Panama CityMyrtle Beach

PTY - MYR

PTYMYR

Panama City Tocumen Intl

Sat 12/6

8:05 am-3:13 pm

1 stop7h 08m

Myrtle Beach Intl

Sat 12/13

6:00 am-8:01 pm

1 stop14h 01m

$907

Panama CityColumbia

PTY - CAE

PTYCAE

Panama City Tocumen Intl

Tue 8/26

10:29 pm-9:49 am

1 stop10h 20m

Columbia Metropolitan

Wed 11/5

7:35 pm-6:13 am

1 stop10h 38m

$1,346

Panama CityColumbia

PTY - CAE

PTYCAE

Panama City Tocumen Intl

Mon 8/18

10:29 pm-9:49 am

1 stop10h 20m

Columbia Metropolitan

Sat 9/6

10:24 am-8:34 pm

1 stop11h 10m

$1,823

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Panama City to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Wednesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $502. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $552.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Panama City to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $469. Try not to purchase tickets in the afternoon because they tend to be around $554. Of course, these prices can vary depending on the time of year and what airport you fly to.

Cheap Panama City to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to South Carolina

Best Price Found

$221

Fastest flight time

7h 03m

Direct flights

None

Airports in South Carolina

5 airports
The best one-way flight to South Carolina from Panama City in the past 72 hours is $221. The best round-trip flight deal from Panama City to South Carolina found on momondo in the last 72 hours is $390.
The fastest flight from Panama City to South Carolina takes 7h 03m
There are no direct flights from Panama City to South Carolina. Popular non-direct routes for this connection are Panama City Tocumen Intl Airport - Charleston Airport, Panama City Tocumen Intl Airport - Greenville Airport and Panama City Tocumen Intl Airport - Charlotte Douglas Airport.
There are 5 airports near South Carolina: Greenville (GSP), Columbia Metropolitan (CAE), Myrtle Beach Intl (MYR), Charlotte Douglas (CLT), Charleston (CHS)
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  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to South Carolina?

    Prices for flights from Panama City Tocumen Intl Airport to South Carolina are refreshed on a daily basis.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to South Carolina?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to South Carolina?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Panama City to South Carolina

Compare and see reviews for airlines that fly from Panama City to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $397Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama City to South Carolina for you.

Can I find flights from Panama City to South Carolina with flexible booking policies on momondo?

All flight searches from Panama City to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to South Carolina?

momondo provides multiple filters to help you find the best flight to South Carolina from Panama City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Panama City to South Carolina right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South Carolina from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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