What is the cheapest airline that flies from Panama City Tocumen Intl to South Carolina?

Delta, American Airlines, and United Airlines are the most popular carriers operating from Panama City Tocumen Intl to South Carolina

When did momondo last update prices for flights from Panama City Tocumen Intl Airport to South Carolina?

Prices for flights from Panama City Tocumen Intl Airport to South Carolina are refreshed on a daily basis.

How many operators does momondo search for flights from Panama City Tocumen Intl Airport to South Carolina?

The number of operators available for flights from Panama City Tocumen Intl Airport to South Carolina is 1 as of October 2026.

How old do you have to be to fly from Panama City Tocumen Intl Airport to South Carolina?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$362 Cheap Flights from Panama City to South Carolina in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Panama City to South Carolina

Round-trip

One-way

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Cheap round-trip flights

Enter your travel dates to find the best prices.

11:35 am - 1:50 pmPTY Panama City Tocumen Intl-CAE Columbia Metropolitan

26h 15m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

5:33 pm - 2:45 pmCAE Columbia Metropolitan-PTY Panama City Tocumen Intl

21h 12m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

$661United Airlines

Thu, Jan 21 - Mon, Jan 25

11:35 am - 1:50 pmPTY Panama City Tocumen Intl-CAE Columbia Metropolitan

26h 15m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

6:15 am - 7:38 pmCAE Columbia Metropolitan-PTY Panama City Tocumen Intl

13h 23m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

$682United Airlines

Thu, Jan 21 - Mon, Jan 25

11:35 am - 1:50 pmPTY Panama City Tocumen Intl-CAE Columbia Metropolitan

26h 15m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

5:33 pm - 2:45 pmCAE Columbia Metropolitan-PTY Panama City Tocumen Intl

21h 12m2 stops Chicago O'Hare Intl Houston George Bush Intcntl

$682United Airlines

Thu, Jan 21 - Mon, Jan 25

4:41 pm - 4:00 pmPTY Panama City Tocumen Intl-CHS Charleston

23h 19m1 stop Houston George Bush Intcntl

7:51 pm - 5:12 pmCHS Charleston-PTY Panama City Tocumen Intl

21h 21m2 stops Washington, D.C. Dulles Intl Houston George Bush Intcntl

$698United Airlines

Tue, Jan 19 - Thu, Jan 21

4:41 pm - 7:08 pmPTY Panama City Tocumen Intl-CHS Charleston

26h 27m2 stops Houston George Bush Intcntl Washington, D.C. Dulles Intl

7:51 pm - 2:45 pmCHS Charleston-PTY Panama City Tocumen Intl

18h 54m2 stops Washington, D.C. Dulles Intl Houston George Bush Intcntl

$698United Airlines

Tue, Jan 19 - Thu, Jan 21

4:41 pm - 4:00 pmPTY Panama City Tocumen Intl-CHS Charleston

23h 19m1 stop Houston George Bush Intcntl

4:50 pm - 7:38 pmCHS Charleston-PTY Panama City Tocumen Intl

26h 48m1 stop Houston George Bush Intcntl

$698United Airlines

Tue, Jan 19 - Thu, Jan 21

4:41 pm - 2:17 pmPTY Panama City Tocumen Intl-CAE Columbia Metropolitan

21h 36m2 stops Houston George Bush Intcntl Washington, D.C. Dulles Intl

2:59 pm - 7:38 pmCAE Columbia Metropolitan-PTY Panama City Tocumen Intl

28h 39m2 stops Washington, D.C. Dulles Intl Houston George Bush Intcntl

$702United Airlines

Mon, Nov 9 - Tue, Jan 19

3:29 pm - 11:53 pmPTY Panama City Tocumen Intl-CAE Columbia Metropolitan

8h 24m1 stop Atlanta Hartsfield-Jackson

5:40 am - 1:55 pmCAE Columbia Metropolitan-PTY Panama City Tocumen Intl

8h 15m1 stop Atlanta Hartsfield-Jackson

$713Delta

Mon, Nov 9 - Tue, Jan 19

3:13 pm - 2:06 pmPTY Panama City Tocumen Intl-CAE Columbia Metropolitan

22h 53m2 stops Miami Charlotte Douglas

7:12 pm - 3:55 pmCAE Columbia Metropolitan-PTY Panama City Tocumen Intl

20h 43m2 stops Charlotte Douglas Miami

$748American Airlines

Wed, Nov 4 - Fri, Jan 8

3:13 pm - 10:36 amPTY Panama City Tocumen Intl-CAE Columbia Metropolitan

19h 23m2 stops Miami Charlotte Douglas

8:17 pm - 2:13 pmCAE Columbia Metropolitan-PTY Panama City Tocumen Intl

17h 56m2 stops Charlotte Douglas Miami

$831American Airlines

Thu, Dec 3 - Thu, Dec 10

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United Airlines flights from Panama City to South Carolina

Our best United Airlines deals on Panama City to South Carolina flight tickets

United Airlines

Jan 21

PTY11:35 amPanama City Tocumen Intl

26h 15m

2 stops

CAE1:50 pmColumbia Metropolitan

Jan 25

CAE5:33 pmColumbia Metropolitan

21h 12m

2 stops

PTY2:45 pmPanama City Tocumen Intl

$661

United Airlines

Jan 21

PTY11:35 amPanama City Tocumen Intl

26h 15m

2 stops

CAE1:50 pmColumbia Metropolitan

Jan 25

CAE5:33 pmColumbia Metropolitan

21h 12m

2 stops

PTY2:45 pmPanama City Tocumen Intl

$682

United Airlines

Jan 19

PTY4:41 pmPanama City Tocumen Intl

23h 19m

1 stop

CHS4:00 pmCharleston

Jan 21

CHS4:50 pmCharleston

26h 48m

1 stop

PTY7:38 pmPanama City Tocumen Intl

$698

Delta flights from Panama City to South Carolina

Our best Delta deals on Panama City to South Carolina flight tickets

Delta

Nov 9

PTY3:29 pmPanama City Tocumen Intl

8h 24m

1 stop

CAE11:53 pmColumbia Metropolitan

Jan 19

CAE5:40 amColumbia Metropolitan

8h 15m

1 stop

PTY1:55 pmPanama City Tocumen Intl

$713

Delta

Jan 10

PTY8:00 amPanama City Tocumen Intl

8h 51m

1 stop

CHS4:51 pmCharleston

Jan 16

CHS6:00 amCharleston

6h 15m

1 stop

PTY12:15 pmPanama City Tocumen Intl

$737

Delta

Nov 9

PTY3:29 pmPanama City Tocumen Intl

8h 24m

1 stop

CAE11:53 pmColumbia Metropolitan

Jan 19

CAE5:40 amColumbia Metropolitan

8h 15m

1 stop

PTY1:55 pmPanama City Tocumen Intl

$747

momondo Fare Finder

Use the filters below to find and compare flights from Panama City to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityColumbia

PTY Panama City Tocumen Intl - CAE Columbia Metropolitan

PTYCAE

Panama City Tocumen Intl

Thu 1/21

11:35 am-1:50 pm

2 stops26h 15m

Columbia Metropolitan

Mon 1/25

5:33 pm-2:45 pm

2 stops21h 12m

$661

Panama CityColumbia

PTY Panama City Tocumen Intl - CAE Columbia Metropolitan

PTYCAE

Panama City Tocumen Intl

Thu 1/21

11:35 am-1:50 pm

2 stops26h 15m

Columbia Metropolitan

Mon 1/25

6:15 am-7:38 pm

2 stops13h 23m

$682

Panama CityColumbia

PTY Panama City Tocumen Intl - CAE Columbia Metropolitan

PTYCAE

Panama City Tocumen Intl

Thu 1/21

11:35 am-1:50 pm

2 stops26h 15m

Columbia Metropolitan

Mon 1/25

5:33 pm-2:45 pm

2 stops21h 12m

$682

Panama CityCharleston

PTY Panama City Tocumen Intl - CHS Charleston

PTYCHS

Panama City Tocumen Intl

Tue 1/19

4:41 pm-4:00 pm

1 stop23h 19m

Charleston

Thu 1/21

7:51 pm-5:12 pm

2 stops21h 21m

$698

Panama CityCharleston

PTY Panama City Tocumen Intl - CHS Charleston

PTYCHS

Panama City Tocumen Intl

Tue 1/19

4:41 pm-7:08 pm

2 stops26h 27m

Charleston

Thu 1/21

7:51 pm-2:45 pm

2 stops18h 54m

$698

Panama CityCharleston

PTY Panama City Tocumen Intl - CHS Charleston

PTYCHS

Panama City Tocumen Intl

Tue 1/19

4:41 pm-4:00 pm

1 stop23h 19m

Charleston

Thu 1/21

4:50 pm-7:38 pm

1 stop26h 48m

$698

Panama CityColumbia

PTY Panama City Tocumen Intl - CAE Columbia Metropolitan

PTYCAE

Panama City Tocumen Intl

Mon 11/9

4:41 pm-2:17 pm

2 stops21h 36m

Columbia Metropolitan

Tue 1/19

2:59 pm-7:38 pm

2 stops28h 39m

$702

Quickest round-trip

Panama CityColumbia

PTY Panama City Tocumen Intl - CAE Columbia Metropolitan

PTYCAE

Panama City Tocumen Intl

Mon 11/9

3:29 pm-11:53 pm

1 stop8h 24m

Columbia Metropolitan

Tue 1/19

5:40 am-1:55 pm

1 stop8h 15m

$713

Panama CityColumbia

PTY Panama City Tocumen Intl - CAE Columbia Metropolitan

PTYCAE

Panama City Tocumen Intl

Wed 11/4

3:13 pm-2:06 pm

2 stops22h 53m

Columbia Metropolitan

Fri 1/8

7:12 pm-3:55 pm

2 stops20h 43m

$748

Panama CityColumbia

PTY Panama City Tocumen Intl - CAE Columbia Metropolitan

PTYCAE

Panama City Tocumen Intl

Thu 12/3

3:13 pm-10:36 am

2 stops19h 23m

Columbia Metropolitan

Thu 12/10

8:17 pm-2:13 pm

2 stops17h 56m

$831

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Panama City to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Panama City is in December. Flight prices, which tend to average around $376, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of December, then book flights to South Carolina from Panama City during September instead. Flights to South Carolina in September, while not as cheap as those in December, still average around $446.

Can stopping save me money on Panama City to South Carolina flights?

You could potentially save up to 29% on your flight if you consider stops on a Panama City to South Carolina flight.

Cheap Panama City to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to South Carolina

Best Price Found	$362
Fastest flight time	8h 23m
Direct flights	None

The best one-way flight to South Carolina from Panama City in the past 72 hours is $362. The best round-trip flight deal from Panama City to South Carolina found on momondo in the last 72 hours is $661.

The fastest flight from Panama City to South Carolina takes 8h 23m

There are no direct flights from Panama City to South Carolina. There are no popular flight routes from Panama City to South Carolina.

Search flight deals

Frequently asked questions about flying from Panama City to South Carolina

When did momondo last update prices for flights from Panama City Tocumen Intl Airport to South Carolina?
Prices for flights from Panama City Tocumen Intl Airport to South Carolina are refreshed on a daily basis.
How many operators does momondo search for flights from Panama City Tocumen Intl Airport to South Carolina?
The number of operators available for flights from Panama City Tocumen Intl Airport to South Carolina is 1 as of October 2026.
How old do you have to be to fly from Panama City Tocumen Intl Airport to South Carolina?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Panama City to South Carolina

Compare and see reviews for airlines that fly from Panama City to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $431	Free Cancellation	Rating 7.0 12,193 reviews		Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama City to South Carolina for you.

Can I find flights from Panama City to South Carolina with flexible booking policies on momondo?

All flight searches from Panama City to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to South Carolina?

momondo provides multiple filters to help you find the best flight to South Carolina from Panama City. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Panama City to South Carolina right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to South Carolina from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.