Cheap flights from Panama City to Chicago from $335

The month of November is, on average, the cheapest month to fly to Chicago from Panama City, with most prices found around $576. If you’re not able to fly to Chicago in November, then February is your next best option. Flight prices from Panama City to Chicago during February average around $581.

The cheapest day to depart on your flight to Chicago is on a Saturday when prices can be found for as low as $574. This is often the case because there is less demand to fly during this day of the week. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Panama City to Chicago for around $1,003.

Our most recent data shows that the best time of day to fly to Chicago is in the evening. Flights from Panama City to Chicago during this time can be as low as $781. In contrast, the most expensive time of day to depart to Chicago is in the morning when prices are around $842.

Fly from Panama City Tocumen Intl to Chicago O'Hare Intl for the best Panama City Tocumen Intl - Chicago flight prices

You are more likely to see cheaper flights to Chicago from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago for around $716 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago from Panama City for as low as $417 on momondo.

There are 3 cabin classes available to choose from on Panama City to Chicago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 24% on your flight if you consider stops on a Panama City to Chicago flight.

As of September 2026, prices for Panama City to Chicago flights are approximately 49% cheaper when compared to flights at the same time last year.

As of September 2026, there are 4 flights per day flying from Panama City to Chicago. The most common time of day flights depart is 7:00PM, with 60% of flights taking off in the evening.

As of September 2026, there are 29 flights per week flying from Panama City to Chicago. The most common day of the week flights depart is Mon, with 17% of flights taking off on this day.