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Cheap flights from Panama City to Chicago from $388

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Panama City to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
4:55 pm - 9:30 amPTY  Panama City Tocumen Intl-ORD Chicago O'Hare Intl
17h 35m1 stop Miami
American Airlines Logo
5:00 am - 1:26 pmORD  Chicago O'Hare Intl-PTY Panama City Tocumen Intl
7h 26m1 stop Miami
$720American Airlines
Thu, Jan 21 - Tue, Feb 9
American Airlines Logo
4:55 pm - 7:32 amPTY  Panama City Tocumen Intl-ORD Chicago O'Hare Intl
15h 37m2 stops Miami Philadelphia
American Airlines Logo
5:59 pm - 1:26 pmORD  Chicago O'Hare Intl-PTY Panama City Tocumen Intl
18h 27m1 stop Miami
$724American Airlines
Thu, Jan 21 - Tue, Feb 9
American Airlines Logo
4:24 pm - 12:47 amPTY  Panama City Tocumen Intl-ORD Chicago O'Hare Intl
9h 23m1 stop Miami
American Airlines Logo
6:00 am - 2:24 pmORD  Chicago O'Hare Intl-PTY Panama City Tocumen Intl
8h 24m1 stop Miami
$736American Airlines
Wed, Mar 10 - Tue, Mar 16
American Airlines Logo
3:24 pm - 11:10 amPTY  Panama City Tocumen Intl-ORD Chicago O'Hare Intl
19h 46m1 stop Miami
American Airlines Logo
2:20 pm - 12:36 pmORD  Chicago O'Hare Intl-PTY Panama City Tocumen Intl
22h 16m1 stop Miami
$736American Airlines
Wed, Mar 31 - Mon, Apr 5
American Airlines Logo
4:55 pm - 1:05 amPTY  Panama City Tocumen Intl-ORD Chicago O'Hare Intl
9h 10m1 stop Miami
American Airlines Logo
5:59 pm - 1:26 pmORD  Chicago O'Hare Intl-PTY Panama City Tocumen Intl
18h 27m1 stop Miami
$736American Airlines
Fri, Feb 5 - Tue, Feb 9
American Airlines Logo
2:25 pm - 8:10 amPTY  Panama City Tocumen Intl-ORD Chicago O'Hare Intl
18h 45m1 stop Miami
American Airlines Logo
7:29 pm - 3:24 pmORD  Chicago O'Hare Intl-PTY Panama City Tocumen Intl
18h 55m1 stop Miami
$737American Airlines
Tue, Mar 2 - Tue, Mar 9
American Airlines Logo
4:24 pm - 12:47 amPTY  Panama City Tocumen Intl-ORD Chicago O'Hare Intl
9h 23m1 stop Miami
American Airlines Logo
6:00 am - 2:24 pmORD  Chicago O'Hare Intl-PTY Panama City Tocumen Intl
8h 24m1 stop Miami
$737American Airlines
Wed, Mar 10 - Tue, Mar 16
American Airlines Logo
4:24 pm - 11:10 amPTY  Panama City Tocumen Intl-ORD Chicago O'Hare Intl
19h 46m1 stop Miami
American Airlines Logo
4:51 pm - 3:24 pmORD  Chicago O'Hare Intl-PTY Panama City Tocumen Intl
21h 33m1 stop Miami
$737American Airlines
Tue, Feb 16 - Tue, Feb 23
Copa Airlines Logo
7:55 am - 1:34 pmPTY  Panama City Tocumen Intl-ORD Chicago O'Hare Intl
5h 39mnonstop
Copa Airlines Logo
8:08 am - 1:31 pmORD  Chicago O'Hare Intl-PTY Panama City Tocumen Intl
5h 23mnonstop
$821Copa Airlines
Tue, Apr 6 - Thu, Apr 15
Copa Airlines Logo
7:28 pm - 12:08 amPTY  Panama City Tocumen Intl-ORD Chicago O'Hare Intl
5h 40mnonstop
Copa Airlines Logo
2:13 pm - 8:36 pmORD  Chicago O'Hare Intl-PTY Panama City Tocumen Intl
5h 23mnonstop
$821Copa Airlines
Tue, Mar 2 - Tue, Mar 9

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United Airlines flights from Panama City to Chicago

Our best United Airlines deals on Panama City to Chicago flight tickets
United Airlines
Feb 4
PTY10:00 amPanama City Tocumen Intl
9h 38m
1 stop
ORD6:38 pmChicago O'Hare Intl
Feb 7
ORD7:50 pmChicago O'Hare Intl
17h 55m
1 stop
PTY2:45 pmPanama City Tocumen Intl
$835
United Airlines
Dec 21
PTY11:55 pmPanama City Tocumen Intl
11h 04m
1 stop
ORD9:59 amChicago O'Hare Intl
Jan 2
ORD7:55 amChicago O'Hare Intl
11h 07m
1 stop
PTY8:02 pmPanama City Tocumen Intl
$844
United Airlines
Nov 22
PTY4:41 pmPanama City Tocumen Intl
24h 48m
1 stop
ORD4:29 pmChicago O'Hare Intl
Nov 27
ORD10:34 amChicago O'Hare Intl
8h 04m
1 stop
PTY7:38 pmPanama City Tocumen Intl
$936

American Airlines flights from Panama City to Chicago

Our best American Airlines deals on Panama City to Chicago flight tickets
American Airlines
Jan 21
PTY4:55 pmPanama City Tocumen Intl
17h 35m
1 stop
ORD9:30 amChicago O'Hare Intl
Feb 9
ORD5:00 amChicago O'Hare Intl
7h 26m
1 stop
PTY1:26 pmPanama City Tocumen Intl
$720
American Airlines
Jan 21
PTY4:55 pmPanama City Tocumen Intl
15h 37m
2 stops
ORD7:32 amChicago O'Hare Intl
Feb 9
ORD5:59 pmChicago O'Hare Intl
18h 27m
1 stop
PTY1:26 pmPanama City Tocumen Intl
$724
American Airlines
Feb 5
PTY4:55 pmPanama City Tocumen Intl
9h 10m
1 stop
ORD1:05 amChicago O'Hare Intl
Feb 9
ORD5:59 pmChicago O'Hare Intl
18h 27m
1 stop
PTY1:26 pmPanama City Tocumen Intl
$736

momondo Fare Finder

 
Use the filters below to find and compare flights from Panama City to Chicago that are best for you.

Fly from

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Route

Depart

Return

Price

Cheapest round-trip

Panama CityChicago

PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl

PTYORD

Panama City Tocumen Intl

Thu 1/21

4:55 pm-9:30 am

1 stop17h 35m

Chicago O'Hare Intl

Tue 2/9

5:00 am-1:26 pm

1 stop7h 26m

$720

Panama CityChicago

PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl

PTYORD

Panama City Tocumen Intl

Thu 1/21

4:55 pm-7:32 am

2 stops15h 37m

Chicago O'Hare Intl

Tue 2/9

5:59 pm-1:26 pm

1 stop18h 27m

$724

Panama CityChicago

PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl

PTYORD

Panama City Tocumen Intl

Wed 3/10

4:24 pm-12:47 am

1 stop9h 23m

Chicago O'Hare Intl

Tue 3/16

6:00 am-2:24 pm

1 stop8h 24m

$736

Panama CityChicago

PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl

PTYORD

Panama City Tocumen Intl

Wed 3/31

3:24 pm-11:10 am

1 stop19h 46m

Chicago O'Hare Intl

Mon 4/5

2:20 pm-12:36 pm

1 stop22h 16m

$736

Panama CityChicago

PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl

PTYORD

Panama City Tocumen Intl

Fri 2/5

4:55 pm-1:05 am

1 stop9h 10m

Chicago O'Hare Intl

Tue 2/9

5:59 pm-1:26 pm

1 stop18h 27m

$736

Panama CityChicago

PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl

PTYORD

Panama City Tocumen Intl

Tue 3/2

2:25 pm-8:10 am

1 stop18h 45m

Chicago O'Hare Intl

Tue 3/9

7:29 pm-3:24 pm

1 stop18h 55m

$737

Panama CityChicago

PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl

PTYORD

Panama City Tocumen Intl

Wed 3/10

4:24 pm-12:47 am

1 stop9h 23m

Chicago O'Hare Intl

Tue 3/16

6:00 am-2:24 pm

1 stop8h 24m

$737

Panama CityChicago

PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl

PTYORD

Panama City Tocumen Intl

Tue 2/16

4:24 pm-11:10 am

1 stop19h 46m

Chicago O'Hare Intl

Tue 2/23

4:51 pm-3:24 pm

1 stop21h 33m

$737
Quickest round-trip

Panama CityChicago

PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl

PTYORD

Panama City Tocumen Intl

Tue 4/6

7:55 am-1:34 pm

Nonstop5h 39m

Chicago O'Hare Intl

Thu 4/15

8:08 am-1:31 pm

Nonstop5h 23m

$821

Panama CityChicago

PTY Panama City Tocumen Intl - ORD Chicago O'Hare Intl

PTYORD

Panama City Tocumen Intl

Tue 3/2

7:28 pm-12:08 am

Nonstop5h 40m

Chicago O'Hare Intl

Tue 3/9

2:13 pm-8:36 pm

Nonstop5h 23m

$821

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Chicago from

How to get the cheapest flight ticket from Panama City to Chicago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City and Chicago?

Prices are currently typical for flights on this route.

Typical prices usually range from $609 to $843.
The lowest price recently found on this route was $720.

What is the cheapest month to fly to Chicago?

The month of April is, on average, the cheapest month to fly to Chicago from Panama City, with most prices found around $586. If you’re not able to fly to Chicago in April, then January is your next best option. Flight prices from Panama City to Chicago during January average around $633.

What is the cheapest day to depart on your flight to Chicago?

The cheapest day to depart on your flight to Chicago is on a Wednesday when prices can be found for as low as $779. This is often the case because there is less demand to fly during this day of the week. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Panama City to Chicago for around $1,093.

What is the cheapest time of day to depart on your flight to Chicago?

Our most recent data shows that the best time of day to fly to Chicago is in the evening. Flights from Panama City to Chicago during this time can be as low as $879. In contrast, the most expensive time of day to depart to Chicago is in the morning when prices are around $886.

What is the cheapest Panama City Tocumen Intl to Chicago flight route?

Fly from Panama City Tocumen Intl to Chicago O'Hare Intl for the best Panama City Tocumen Intl - Chicago flight prices

What cabin class options are available on Panama City to Chicago flights?

There are 3 cabin classes available to choose from on Panama City to Chicago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Panama City to Chicago flights?

No. A direct flight is the cheapest option for a flight between Panama City to Chicago.

How have Panama City to Chicago flight prices changed over time?

As of November 2026, prices for Panama City to Chicago flights are approximately 158% more expensive when compared to flights at the same time last year.

When to book flights from Panama City to Chicago

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Chicago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Chicago (PTY to CHI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Chicago

Best Price Found

$388

Fastest flight time

5h 38m

Direct flights

Every day

Airports in Chicago

3 airports
The best one-way flight to Chicago from Panama City in the past 72 hours is $388. The best round-trip flight deal from Panama City to Chicago found on momondo in the last 72 hours is $720.
The fastest flight from Panama City to Chicago takes 5h 38m
Direct flights go from Panama City to Chicago every day.
There are 3 airports in Chicago. From Panama City there are direct flights to Chicago O'Hare Intl (ORD).
Search flight deals

Frequently asked questions about flying from Panama City to Chicago

  • How far is Panama City Tocumen Intl to Chicago by plane?

    Panama City Tocumen Intl and Chicago are 2323.9 mi apart from one another. Typically, this will take 5h 38m by plane in normal conditions.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Chicago?

    Prices for flights from Panama City Tocumen Intl Airport to Chicago refresh daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Chicago?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Chicago?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Chicago.

  • What documentation or ID do you need to fly to Chicago?

    The required travel and health documents for your Chicago trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Chicago. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Panama City to Chicago?

  • What is the most popular airline from Panama City to Chicago?

Best airlines flying from Panama City to Chicago

Compare and see reviews for airlines that fly from Panama City to Chicago with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $574Free CancellationRating
7.6
1,555 reviews
Search Copa Airlines flights

  • Copa Airlines Flights From Panama City to Chicago

    Copa Airlines flight deals from Panama City to Chicago start from $574 round-trip. Over the 12 Copa Airlines flights for this route in a normal week, average airfare is usually $841 round-trip - but some users have found much cheaper deals with momondo.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Portage
Lansing
Benton Harbor
Saint Joseph
Valparaiso
Schererville
Munster
Chesterton
Monticello
Crown Point
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Chicago?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Panama City to Chicago. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Panama City to Chicago with flexible booking policies on momondo?

Flights from Panama City to Chicago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama City to Chicago?

Once you have performed a search for Panama City to Chicago flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to Chicago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Chicago from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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Find better results for your trip to the United States

Fly into one of these airports located in Chicago

Chicago Midway Airport
Chicago O'Hare Intl Airport
Chicago Greater Rockford Airport