Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Panama City to Chicago from $281

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Chicago departing on 6/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Panama City to Chicago

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
9:48 pm - 7:53 am
PTY
-
ORD
34h 05m
2 stops
Multiple Airlines Logo
7:10 am - 7:20 pm
ORD
-
PTY
12h 10m
1 stop
$602Multiple Airlines
Mon, Jul 20 - Sat, Aug 8
Multiple Airlines Logo
8:25 am - 7:53 am
PTY
-
ORD
23h 28m
2 stops
Multiple Airlines Logo
7:10 am - 7:20 pm
ORD
-
PTY
12h 10m
1 stop
$618Multiple Airlines
Tue, Jul 21 - Sat, Aug 8
Multiple Airlines Logo
10:25 am - 7:53 am
PTY
-
ORD
21h 28m
2 stops
Multiple Airlines Logo
7:10 am - 8:06 am
ORD
-
PTY
24h 56m
1 stop
$622Multiple Airlines
Tue, Jul 21 - Mon, Aug 10
Multiple Airlines Logo
3:10 pm - 12:03 pm
PTY
-
ORD
20h 53m
2 stops
Multiple Airlines Logo
7:10 am - 7:20 pm
ORD
-
PTY
12h 10m
1 stop
$625Multiple Airlines
Wed, Jul 22 - Sat, Aug 8
Multiple Airlines Logo
9:48 pm - 12:03 pm
PTY
-
ORD
14h 15m
1 stop
Multiple Airlines Logo
7:10 am - 8:06 am
ORD
-
PTY
24h 56m
1 stop
$631Multiple Airlines
Wed, Jul 22 - Mon, Aug 10
Multiple Airlines Logo
6:34 pm - 12:03 pm
PTY
-
ORD
17h 29m
1 stop
Multiple Airlines Logo
7:10 am - 8:37 pm
ORD
-
PTY
13h 27m
1 stop
$649Multiple Airlines
Wed, Jul 22 - Sat, Aug 8
Multiple Airlines Logo
9:48 pm - 7:53 pm
PTY
-
ORD
22h 05m
2 stops
Multiple Airlines Logo
7:10 am - 7:20 pm
ORD
-
PTY
12h 10m
1 stop
$650Multiple Airlines
Sun, Jul 19 - Sat, Aug 8
Multiple Airlines Logo
9:48 pm - 12:03 pm
PTY
-
ORD
14h 15m
1 stop
Multiple Airlines Logo
1:50 pm - 8:06 am
ORD
-
PTY
18h 16m
2 stops
$656Multiple Airlines
Sun, Jul 19 - Wed, Aug 12
Multiple Airlines Logo
10:26 am - 7:50 pm
PTY
-
ORD
9h 24m
1 stop
Multiple Airlines Logo
1:29 pm - 8:06 am
ORD
-
PTY
18h 37m
2 stops
$657Multiple Airlines
Wed, Jun 17 - Wed, Jun 24
Delta Logo
2:27 pm - 10:15 pm
PTY
-
MDW
7h 48m
1 stop
Delta Logo
6:05 am - 12:55 pm
MDW
-
PTY
6h 50m
1 stop
$719Delta
Sat, Aug 1 - Sun, Aug 9

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Avianca flights from Panama City to Chicago

Our best Avianca deals on Panama City to Chicago flight tickets
Avianca
Jun 1
PTY4:25 amPanama City Tocumen Intl
16h 55m
1 stop
ORD9:20 pmChicago O'Hare Intl
Jun 9
ORD11:20 pmChicago O'Hare Intl
9h 55m
1 stop
PTY9:15 amPanama City Tocumen Intl
$687
Avianca
Jun 18
PTY4:25 amPanama City Tocumen Intl
16h 55m
1 stop
ORD9:20 pmChicago O'Hare Intl
Jun 25
ORD5:15 pmChicago O'Hare Intl
8h 40m
1 stop
PTY1:55 amPanama City Tocumen Intl
$688
Avianca
May 11
PTY10:10 amPanama City Tocumen Intl
11h 10m
1 stop
ORD9:20 pmChicago O'Hare Intl
May 15
ORD11:20 pmChicago O'Hare Intl
17h 40m
1 stop
PTY5:00 pmPanama City Tocumen Intl
$693

United Airlines flights from Panama City to Chicago

Our best United Airlines deals on Panama City to Chicago flight tickets
United Airlines
Jul 9
PTY9:45 amPanama City Tocumen Intl
11h 15m
1 stop
ORD9:00 pmChicago O'Hare Intl
Jul 15
ORD5:30 amChicago O'Hare Intl
8h 44m
1 stop
PTY2:14 pmPanama City Tocumen Intl
$717
United Airlines
Jul 20
PTY3:30 pmPanama City Tocumen Intl
9h 15m
1 stop
ORD12:45 amChicago O'Hare Intl
Aug 9
ORD5:30 amChicago O'Hare Intl
8h 44m
1 stop
PTY2:14 pmPanama City Tocumen Intl
$721
United Airlines
Jul 9
PTY10:00 amPanama City Tocumen Intl
11h 40m
1 stop
ORD9:40 pmChicago O'Hare Intl
Jul 15
ORD5:30 amChicago O'Hare Intl
8h 44m
1 stop
PTY2:14 pmPanama City Tocumen Intl
$722

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from Panama City to Chicago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Mon 7/20

9:48 pm-7:53 am

2 stops34h 05m

Chicago O'Hare Intl

Sat 8/8

7:10 am-7:20 pm

1 stop12h 10m

$602

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Tue 7/21

8:25 am-7:53 am

2 stops23h 28m

Chicago O'Hare Intl

Sat 8/8

7:10 am-7:20 pm

1 stop12h 10m

$618

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Tue 7/21

10:25 am-7:53 am

2 stops21h 28m

Chicago O'Hare Intl

Mon 8/10

7:10 am-8:06 am

1 stop24h 56m

$622

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Wed 7/22

3:10 pm-12:03 pm

2 stops20h 53m

Chicago O'Hare Intl

Sat 8/8

7:10 am-7:20 pm

1 stop12h 10m

$625

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Wed 7/22

9:48 pm-12:03 pm

1 stop14h 15m

Chicago O'Hare Intl

Mon 8/10

7:10 am-8:06 am

1 stop24h 56m

$631

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Wed 7/22

6:34 pm-12:03 pm

1 stop17h 29m

Chicago O'Hare Intl

Sat 8/8

7:10 am-8:37 pm

1 stop13h 27m

$649

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sun 7/19

9:48 pm-7:53 pm

2 stops22h 05m

Chicago O'Hare Intl

Sat 8/8

7:10 am-7:20 pm

1 stop12h 10m

$650

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Sun 7/19

9:48 pm-12:03 pm

1 stop14h 15m

Chicago O'Hare Intl

Wed 8/12

1:50 pm-8:06 am

2 stops18h 16m

$656

Panama CityChicago

PTY - ORD

PTYORD

Panama City Tocumen Intl

Wed 6/17

10:26 am-7:50 pm

1 stop9h 24m

Chicago O'Hare Intl

Wed 6/24

1:29 pm-8:06 am

2 stops18h 37m

$657
Quickest round-trip

Panama CityChicago

PTY - MDW

PTYMDW

Panama City Tocumen Intl

Sat 8/1

2:27 pm-10:15 pm

1 stop7h 48m

Chicago Midway

Sun 8/9

6:05 am-12:55 pm

1 stop6h 50m

$719

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Chicago from

How to get the cheapest flight ticket from Panama City to Chicago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City and Chicago?

What is the cheapest month to fly to Chicago?

The month of May is, on average, the cheapest month to fly to Chicago from Panama City, with most prices found around $201. If you’re not able to fly to Chicago in May, then July is your next best option. Flight prices from Panama City to Chicago during July average around $210.

What is the cheapest day to depart on your flight to Chicago?

The cheapest day to depart on your flight to Chicago is on a Wednesday when prices can be found for as low as $494. This is often the case because there is less demand to fly during this day of the week. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Panama City to Chicago for around $887.

What is the cheapest time of day to depart on your flight to Chicago?

Our most recent data shows that the best time of day to fly to Chicago is in the afternoon. Flights from Panama City to Chicago during this time can be as low as $496. In contrast, the most expensive time of day to depart to Chicago is in the morning when prices are around $756.

What is the cheapest Panama City Tocumen Intl to Chicago flight route?

Fly from Panama City Tocumen Intl to Chicago O'Hare Intl for the best Panama City Tocumen Intl - Chicago flight prices

How far in advance should I book a flight from Panama City to Chicago?

You are more likely to see cheaper flights to Chicago from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago for around $596 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago from Panama City for as low as $471 on momondo.

Can stopping save me money on Panama City to Chicago flights?

You could potentially save up to 11% on your flight if you consider stops on a Panama City to Chicago flight.

How have Panama City to Chicago flight prices changed over time?

As of May 2026, prices for Panama City to Chicago flights are approximately 0% cheaper when compared to flights at the same time last year.

When to book flights from Panama City to Chicago

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Chicago according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Chicago (PTY to CHI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Chicago

Best Price Found

$392

Fastest flight time

5h 36m

Direct flights

Every day

Airports in Chicago

3 airports
The best one-way flight to Chicago from Panama City in the past 72 hours is $392. The best round-trip flight deal from Panama City to Chicago found on momondo in the last 72 hours is $781.
The fastest flight from Panama City to Chicago takes 5h 36m
Direct flights go from Panama City to Chicago every day.
There are 3 airports in Chicago. From Panama City there are direct flights to Chicago O'Hare Intl (ORD).
Search flight deals

Frequently asked questions about flying from Panama City to Chicago

  • How far is Panama City Tocumen Intl to Chicago by plane?

    Panama City Tocumen Intl and Chicago are 2323.9 mi apart from one another. Typically, this will take 5h 36m by plane in normal conditions.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Chicago?

    Prices for flights from Panama City Tocumen Intl Airport to Chicago refresh daily.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Chicago?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Chicago?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Chicago.

  • What documentation or ID do you need to fly to Chicago?

    The required travel and health documents for your Chicago trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Chicago. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Panama City to Chicago?

  • What is the most popular airline from Panama City to Chicago?

Best airlines flying from Panama City to Chicago

Compare and see reviews for airlines that fly from Panama City to Chicago with momondo
Airline
Rating
Free Cancellation
Price
Copa AirlinesPriceFrom $405Free CancellationRating
7.5
1,580 reviews
Search Copa Airlines flights

  • Copa Airlines Flights From Panama City to Chicago

    Copa Airlines flight deals from Panama City to Chicago start from $405 round-trip. Over the 11 Copa Airlines flights for this route in a normal week, average airfare is usually $655 round-trip - but some users have found much cheaper deals with momondo.

Traveling to a place near Chicago?

Book flights to Chicago if you plan to visit one of these locations
Merrillville
New Buffalo
Hammond
Saint Joseph
Benton Harbor
Portage
Lansing
Valparaiso
Munster
Schererville
Crown Point
Monticello
Chesterton
Porter
Griffith
Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Chicago?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Panama City to Chicago. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Panama City to Chicago with flexible booking policies on momondo?

Flights from Panama City to Chicago with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama City to Chicago?

Once you have performed a search for Panama City to Chicago flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to Chicago right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Chicago from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Chicago trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 6/4
Thu 6/11
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States

Fly into one of these airports located in Chicago

Airports listed have a maximum distance of 78.5 mi from Chicago
Chicago Midway Airport
Chicago O'Hare Intl Airport
Chicago Greater Rockford Airport