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Cheap flights from Panama City, Florida to Louisville from $152

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Louisville departing on 12/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City, Florida to Louisville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:40 pm - 12:06 amECP-SDF
4h 26m1 stop
Delta Logo
12:57 pm - 5:55 pmSDF-ECP
5h 58m1 stop
$387Delta
Find Deal
Wed, Nov 26 - Sun, Nov 30
Delta Logo
4:26 pm - 8:52 pmECP-SDF
3h 26m1 stop
Delta Logo
8:35 am - 12:47 pmSDF-ECP
5h 12m1 stop
$447Delta
Find Deal
Mon, Nov 17 - Tue, Nov 18
American Airlines Logo
6:47 am - 1:02 pmECP-SDF
5h 15m1 stop
American Airlines Logo
6:00 am - 12:49 pmSDF-ECP
7h 49m1 stop
$450American Airlines
Find Deal
Thu, Nov 27 - Sun, Nov 30
American Airlines Logo
6:47 am - 3:38 pmECP-SDF
7h 51m1 stop
American Airlines Logo
11:09 am - 4:44 pmSDF-ECP
6h 35m2 stops
$452American Airlines
Find Deal
Mon, Nov 17 - Tue, Nov 18
American Airlines Logo
8:21 am - 8:19 pmECP-SDF
10h 58m2 stops
American Airlines Logo
4:59 pm - 11:15 pmSDF-ECP
7h 16m2 stops
$457American Airlines
Find Deal
Tue, Nov 18 - Wed, Nov 19
American Airlines Logo
6:47 am - 1:02 pmECP-SDF
5h 15m1 stop
American Airlines Logo
7:31 pm - 11:49 pmSDF-ECP
5h 18m1 stop
$471American Airlines
Find Deal
Thu, Nov 27 - Sun, Nov 30
Southwest Logo
1:30 pm - 12:30 amECP-SDF
10h 00m2 stops
Southwest Logo
6:40 am - 8:45 amSDF-ECP
3h 05m1 stop
$509Southwest
Find Deal
Wed, Nov 26 - Sun, Nov 30
Southwest Logo
1:30 pm - 12:30 amECP-SDF
10h 00m2 stops
Southwest Logo
6:40 am - 3:50 pmSDF-ECP
10h 10m2 stops
$535Southwest
Find Deal
Wed, Nov 26 - Sun, Nov 30
United Airlines Logo
6:30 am - 1:25 pmECP-SDF
5h 55m1 stop
United Airlines Logo
8:30 am - 9:49 pmSDF-ECP
14h 19m2 stops
$545United Airlines
Find Deal
Sat, Nov 15 - Tue, Nov 18
United Airlines Logo
10:04 am - 11:40 pmECP-SDF
12h 36m2 stops
United Airlines Logo
7:00 am - 4:03 pmSDF-ECP
10h 03m2 stops
$550United Airlines
Find Deal
Sat, Nov 15 - Tue, Nov 18

Delta flights from Panama City, Florida to Louisville

Our best Delta deals on Panama City, Florida to Louisville flight tickets
Delta
Nov 26
ECP6:40 pmPanama City NW Florida Beaches
4h 26m
1 stop
SDF12:06 amLouisville Intl
Nov 30
SDF12:57 pmLouisville Intl
5h 58m
1 stop
ECP5:55 pmPanama City NW Florida Beaches
$387
Find similar
Delta
Nov 17
ECP4:26 pmPanama City NW Florida Beaches
3h 26m
1 stop
SDF8:52 pmLouisville Intl
Nov 18
SDF8:35 amLouisville Intl
5h 12m
1 stop
ECP12:47 pmPanama City NW Florida Beaches
$447
Find similar
Delta
Nov 15
ECP6:00 amPanama City NW Florida Beaches
6h 12m
1 stop
SDF1:12 pmLouisville Intl
Nov 18
SDF10:37 amLouisville Intl
3h 10m
1 stop
ECP12:47 pmPanama City NW Florida Beaches
$540
Find similar

Southwest flights from Panama City, Florida to Louisville

Our best Southwest deals on Panama City, Florida to Louisville flight tickets
Southwest
Nov 26
ECP1:30 pmPanama City NW Florida Beaches
10h 00m
2 stops
SDF12:30 amLouisville Intl
Nov 30
SDF6:40 amLouisville Intl
3h 05m
1 stop
ECP8:45 amPanama City NW Florida Beaches
$509
Find similar
Southwest
Nov 26
ECP1:30 pmPanama City NW Florida Beaches
10h 00m
2 stops
SDF12:30 amLouisville Intl
Nov 30
SDF6:40 amLouisville Intl
10h 10m
2 stops
ECP3:50 pmPanama City NW Florida Beaches
$535
Find similar
Southwest
Nov 16
ECP7:30 amPanama City NW Florida Beaches
11h 05m
2 stops
SDF7:35 pmLouisville Intl
Nov 21
SDF7:20 amLouisville Intl
6h 35m
1 stop
ECP12:55 pmPanama City NW Florida Beaches
$553
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Panama City, Florida to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Wed 11/26

6:40 pm-12:06 am

1 stop4h 26m

Louisville Intl

Sun 11/30

12:57 pm-5:55 pm

1 stop5h 58m

$387

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Mon 11/17

4:26 pm-8:52 pm

1 stop3h 26m

Louisville Intl

Tue 11/18

8:35 am-12:47 pm

1 stop5h 12m

$447

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Thu 11/27

6:47 am-1:02 pm

1 stop5h 15m

Louisville Intl

Sun 11/30

6:00 am-12:49 pm

1 stop7h 49m

$450

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Mon 11/17

6:47 am-3:38 pm

1 stop7h 51m

Louisville Intl

Tue 11/18

11:09 am-4:44 pm

2 stops6h 35m

$452

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Tue 11/18

8:21 am-8:19 pm

2 stops10h 58m

Louisville Intl

Wed 11/19

4:59 pm-11:15 pm

2 stops7h 16m

$457

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Thu 11/27

6:47 am-1:02 pm

1 stop5h 15m

Louisville Intl

Sun 11/30

7:31 pm-11:49 pm

1 stop5h 18m

$471

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Wed 11/26

1:30 pm-12:30 am

2 stops10h 00m

Louisville Intl

Sun 11/30

6:40 am-8:45 am

1 stop3h 05m

$509

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Wed 11/26

1:30 pm-12:30 am

2 stops10h 00m

Louisville Intl

Sun 11/30

6:40 am-3:50 pm

2 stops10h 10m

$535

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Sat 11/15

6:30 am-1:25 pm

1 stop5h 55m

Louisville Intl

Tue 11/18

8:30 am-9:49 pm

2 stops14h 19m

$545

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Sat 11/15

10:04 am-11:40 pm

2 stops12h 36m

Louisville Intl

Tue 11/18

7:00 am-4:03 pm

2 stops10h 03m

$550

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Louisville from

How to get the cheapest flight ticket from Panama City, Florida to Louisville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Louisville?

If you are unable to visit Louisville during the month of August, then departing from Panama City, Florida during the month June is also very affordable. Most momondo users find prices during this month for around $302.

What is the cheapest day to depart on your flight to Louisville?

On average, the least expensive day to fly to Louisville from Panama City, Florida is on a Tuesday. momondo users have found tickets for Tuesday departures for as low as $246. However, this price may fluctuate depending on the airline, the season, and holidays. Flights from Panama City, Florida to Louisville on a Sunday will generally be more expensive and average around $479. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

How have Panama City, Florida to Louisville flight prices changed over time?

As of November 2025, prices for Panama City, Florida to Louisville flights are approximately 43% cheaper when compared to flights at the same time last year.

When to book flights from Panama City, Florida to Louisville

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Louisville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Louisville (ECP to SDF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Louisville

Direct flights

None
There are no direct flights from Panama City, Florida to Louisville. There are no popular flight routes from Panama City, Florida to Louisville.
Search flight deals

  • How far is Panama City NW Florida Beaches to Louisville Intl by plane?

    A flight from Panama City NW Florida Beaches to Louisville Intl will travel around 558.6 mi. In terms of flight time, this usually takes a little over 3h 26m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Louisville Intl Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Louisville Intl Airport are updated daily.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Louisville Intl Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Louisville Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Louisville Intl Airport.

  • What documentation or ID do you need to fly to Louisville Intl Airport?

    The necessary travel and health documents for your Louisville Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Panama City, Florida to Louisville?

Best airlines flying from Panama City, Florida to Louisville

Compare and see reviews for airlines that fly from Panama City, Florida to Louisville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $236Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights
DeltaPriceFrom $236Free CancellationRating
7.9
8,003 reviews
Search Delta flights

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
French Lick
Elizabethtown
West Baden Springs
Bardstown
Jeffersonville
Shepherdsville
New Albany
Elizabeth
Corydon
Charlestown
Springfield
Georgetown
Brandenburg

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Louisville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Panama City to Louisville. momondo saves you time and could save you money on your trip.

Can I find flights from Panama City to Louisville with flexible booking policies on momondo?

Yes. All flights to Louisville from Panama City on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Panama City to Louisville?

momondo helps you find the best flight between Panama City and Louisville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to Louisville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Panama City to Louisville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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