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Cheap flights from Panama City, Florida to Buffalo from $171

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Buffalo departing on 4/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Panama City, Florida to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:21 am - 1:05 pm
ECP
-
BUF
4h 44m
1 stop
American Airlines Logo
7:28 pm - 11:46 pm
BUF
-
ECP
5h 18m
1 stop
$364American Airlines
Wed, Apr 29 - Wed, Apr 29
Delta Logo
6:06 pm - 11:26 pm
ECP
-
BUF
4h 20m
1 stop
Delta Logo
4:47 pm - 9:22 pm
BUF
-
ECP
5h 35m
1 stop
$387Delta
Thu, Mar 5 - Sun, Mar 8
Delta Logo
2:05 pm - 10:57 pm
ECP
-
BUF
7h 52m
2 stops
Delta Logo
4:47 pm - 9:22 pm
BUF
-
ECP
5h 35m
1 stop
$392Delta
Thu, Mar 5 - Sun, Mar 8
Delta Logo
8:03 am - 4:59 pm
ECP
-
BUF
7h 56m
2 stops
Delta Logo
6:15 am - 3:36 pm
BUF
-
ECP
10h 21m
2 stops
$397Delta
Thu, Mar 5 - Sun, Mar 8
Delta Logo
9:23 am - 3:30 pm
ECP
-
BUF
5h 07m
1 stop
Delta Logo
4:30 pm - 7:36 pm
BUF
-
ECP
4h 06m
1 stop
$423Delta
Thu, Jul 23 - Sun, Jul 26
American Airlines Logo
1:18 pm - 10:50 pm
ECP
-
BUF
8h 32m
2 stops
American Airlines Logo
1:57 pm - 11:49 pm
BUF
-
ECP
10h 52m
2 stops
$424American Airlines
Thu, Mar 5 - Sun, Mar 8
Delta Logo
2:47 pm - 11:03 pm
ECP
-
BUF
7h 16m
2 stops
Delta Logo
4:30 pm - 7:36 pm
BUF
-
ECP
4h 06m
1 stop
$464Delta
Thu, Jul 23 - Sun, Jul 26
Delta Logo
6:00 am - 11:00 am
ECP
-
BUF
4h 00m
1 stop
Delta Logo
2:08 pm - 7:30 pm
BUF
-
ECP
6h 22m
1 stop
$467Delta
Tue, Feb 17 - Sat, Feb 21
Southwest Logo
7:35 am - 1:55 pm
ECP
-
BUF
5h 20m
1 stop
Southwest Logo
8:35 am - 4:00 pm
BUF
-
ECP
8h 25m
2 stops
$472Southwest
Tue, Feb 17 - Sat, Feb 21
Delta Logo
8:03 am - 4:59 pm
ECP
-
BUF
7h 56m
2 stops
Delta Logo
6:01 am - 1:20 pm
BUF
-
ECP
8h 19m
2 stops
$477Delta
Tue, Feb 17 - Sat, Feb 21

American Airlines flights from Panama City, Florida to Buffalo

Our best American Airlines deals on Panama City, Florida to Buffalo flight tickets
American Airlines
Apr 29
ECP7:21 amPanama City NW Florida Beaches
4h 44m
1 stop
BUF1:05 pmBuffalo
Apr 29
BUF7:28 pmBuffalo
5h 18m
1 stop
ECP11:46 pmPanama City NW Florida Beaches
$364
American Airlines
Mar 5
ECP1:18 pmPanama City NW Florida Beaches
8h 32m
2 stops
BUF10:50 pmBuffalo
Mar 8
BUF1:57 pmBuffalo
10h 52m
2 stops
ECP11:49 pmPanama City NW Florida Beaches
$424
American Airlines
Apr 29
ECP7:21 amPanama City NW Florida Beaches
7h 08m
2 stops
BUF3:29 pmBuffalo
Apr 29
BUF5:32 pmBuffalo
7h 14m
2 stops
ECP11:46 pmPanama City NW Florida Beaches
$606

Delta flights from Panama City, Florida to Buffalo

Our best Delta deals on Panama City, Florida to Buffalo flight tickets
Delta
Mar 5
ECP6:06 pmPanama City NW Florida Beaches
4h 20m
1 stop
BUF11:26 pmBuffalo
Mar 8
BUF4:47 pmBuffalo
5h 35m
1 stop
ECP9:22 pmPanama City NW Florida Beaches
$387
Delta
Mar 5
ECP2:05 pmPanama City NW Florida Beaches
7h 52m
2 stops
BUF10:57 pmBuffalo
Mar 8
BUF4:47 pmBuffalo
5h 35m
1 stop
ECP9:22 pmPanama City NW Florida Beaches
$392
Delta
Mar 5
ECP8:03 amPanama City NW Florida Beaches
7h 56m
2 stops
BUF4:59 pmBuffalo
Mar 8
BUF6:15 amBuffalo
10h 21m
2 stops
ECP3:36 pmPanama City NW Florida Beaches
$397

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Panama City, Florida to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Wed 4/29

7:21 am-1:05 pm

1 stop4h 44m

Buffalo

Wed 4/29

7:28 pm-11:46 pm

1 stop5h 18m

$364

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Thu 3/5

6:06 pm-11:26 pm

1 stop4h 20m

Buffalo

Sun 3/8

4:47 pm-9:22 pm

1 stop5h 35m

$387

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Thu 3/5

2:05 pm-10:57 pm

2 stops7h 52m

Buffalo

Sun 3/8

4:47 pm-9:22 pm

1 stop5h 35m

$392

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Thu 3/5

8:03 am-4:59 pm

2 stops7h 56m

Buffalo

Sun 3/8

6:15 am-3:36 pm

2 stops10h 21m

$397

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Thu 7/23

9:23 am-3:30 pm

1 stop5h 07m

Buffalo

Sun 7/26

4:30 pm-7:36 pm

1 stop4h 06m

$423

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Thu 3/5

1:18 pm-10:50 pm

2 stops8h 32m

Buffalo

Sun 3/8

1:57 pm-11:49 pm

2 stops10h 52m

$424

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Thu 7/23

2:47 pm-11:03 pm

2 stops7h 16m

Buffalo

Sun 7/26

4:30 pm-7:36 pm

1 stop4h 06m

$464

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Tue 2/17

6:00 am-11:00 am

1 stop4h 00m

Buffalo

Sat 2/21

2:08 pm-7:30 pm

1 stop6h 22m

$467

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Tue 2/17

7:35 am-1:55 pm

1 stop5h 20m

Buffalo

Sat 2/21

8:35 am-4:00 pm

2 stops8h 25m

$472

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Tue 2/17

8:03 am-4:59 pm

2 stops7h 56m

Buffalo

Sat 2/21

6:01 am-1:20 pm

2 stops8h 19m

$477

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Panama City, Florida to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Panama City NW Florida Beaches to Buffalo?

American Airlines, Southwest, and Delta are the most popular carriers operating from Panama City NW Florida Beaches to Buffalo

When to book flights from Panama City, Florida to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Buffalo (ECP to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Buffalo

Fastest flight time

4h 00m

Direct flights

None
The fastest flight from Panama City, Florida to Buffalo takes 4h 00m
There are no direct flights from Panama City, Florida to Buffalo. There are no popular flight routes from Panama City, Florida to Buffalo.
Search flight deals

  • How far is Panama City NW Florida Beaches to Buffalo by plane?

    Buffalo is 955.1 mi away from Panama City NW Florida Beaches. In terms of flight time, this usually takes a little over 4h 00m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Buffalo Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Buffalo Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Panama City, Florida to Buffalo?

Best airlines flying from Panama City, Florida to Buffalo

Compare and see reviews for airlines that fly from Panama City, Florida to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $236Free CancellationRating
7.2
11,212 reviews
Search American Airlines flights
DeltaPriceFrom $270Free CancellationRating
7.9
8,132 reviews
Search Delta flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Grand Island
Tonawanda
Williamsville
Orchard Park
Lockport
West Seneca
Bowmansville
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Buffalo?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Buffalo from Panama City.

Can I find flights from Panama City to Buffalo with flexible booking policies on momondo?

All flight searches from Panama City to Buffalo on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to Buffalo?

Once you have performed a search for Panama City to Buffalo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to Buffalo right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Buffalo from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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