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Cheap flights from Panama City, Florida to Buffalo from $159

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Buffalo departing on 9/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Panama City, Florida to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:20 pm - 11:54 pm
ECP
-
BUF
4h 34m
1 stop
Delta Logo
6:59 pm - 11:25 pm
BUF
-
ECP
5h 26m
1 stop
$341Delta
Thu, Sep 24 - Mon, Sep 28
American Airlines Logo
11:42 am - 6:02 pm
ECP
-
BUF
5h 20m
1 stop
American Airlines Logo
5:22 am - 11:29 am
BUF
-
ECP
7h 07m
1 stop
$362American Airlines
Tue, Aug 25 - Sun, Aug 30
American Airlines Logo
11:00 am - 6:43 pm
ECP
-
BUF
6h 43m
1 stop
American Airlines Logo
6:59 pm - 10:40 pm
BUF
-
ECP
4h 41m
1 stop
$372American Airlines
Thu, Jul 30 - Wed, Aug 5
American Airlines Logo
3:52 pm - 11:59 pm
ECP
-
BUF
7h 07m
1 stop
American Airlines Logo
6:59 pm - 10:40 pm
BUF
-
ECP
4h 41m
1 stop
$374American Airlines
Sun, Aug 2 - Sat, Aug 8
American Airlines Logo
11:42 am - 6:02 pm
ECP
-
BUF
5h 20m
1 stop
American Airlines Logo
5:22 am - 1:50 pm
BUF
-
ECP
9h 28m
2 stops
$377American Airlines
Tue, Aug 25 - Sun, Aug 30
United Airlines Logo
1:47 pm - 9:07 pm
ECP
-
BUF
6h 20m
1 stop
United Airlines Logo
6:55 am - 1:06 pm
BUF
-
ECP
7h 11m
1 stop
$397United Airlines
Tue, Sep 1 - Wed, Sep 2
Delta Logo
7:35 am - 3:06 pm
ECP
-
BUF
6h 31m
1 stop
Delta Logo
6:05 am - 10:42 am
BUF
-
ECP
5h 37m
1 stop
$407Delta
Fri, Aug 28 - Tue, Sep 1
United Airlines Logo
1:47 pm - 9:07 pm
ECP
-
BUF
6h 20m
1 stop
United Airlines Logo
6:55 am - 4:38 pm
BUF
-
ECP
10h 43m
2 stops
$412United Airlines
Fri, Aug 28 - Mon, Aug 31
United Airlines Logo
1:47 pm - 9:07 pm
ECP
-
BUF
6h 20m
1 stop
United Airlines Logo
6:55 am - 1:06 pm
BUF
-
ECP
7h 11m
1 stop
$421United Airlines
Tue, Sep 1 - Wed, Sep 2
American Airlines Logo
3:52 pm - 11:59 pm
ECP
-
BUF
7h 07m
1 stop
American Airlines Logo
4:54 pm - 10:40 pm
BUF
-
ECP
6h 46m
2 stops
$422American Airlines
Sun, Aug 2 - Sat, Aug 8

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American Airlines flights from Panama City, Florida to Buffalo

Our best American Airlines deals on Panama City, Florida to Buffalo flight tickets
American Airlines
Aug 25
ECP11:42 amPanama City NW Florida Beaches
5h 20m
1 stop
BUF6:02 pmBuffalo
Aug 30
BUF5:22 amBuffalo
7h 07m
1 stop
ECP11:29 amPanama City NW Florida Beaches
$362
American Airlines
Jul 30
ECP11:00 amPanama City NW Florida Beaches
6h 43m
1 stop
BUF6:43 pmBuffalo
Aug 5
BUF6:59 pmBuffalo
4h 41m
1 stop
ECP10:40 pmPanama City NW Florida Beaches
$372
American Airlines
Aug 2
ECP3:52 pmPanama City NW Florida Beaches
7h 07m
1 stop
BUF11:59 pmBuffalo
Aug 8
BUF6:59 pmBuffalo
4h 41m
1 stop
ECP10:40 pmPanama City NW Florida Beaches
$374

Delta flights from Panama City, Florida to Buffalo

Our best Delta deals on Panama City, Florida to Buffalo flight tickets
Delta
Sep 24
ECP6:20 pmPanama City NW Florida Beaches
4h 34m
1 stop
BUF11:54 pmBuffalo
Sep 28
BUF6:59 pmBuffalo
5h 26m
1 stop
ECP11:25 pmPanama City NW Florida Beaches
$341
Delta
Aug 28
ECP7:35 amPanama City NW Florida Beaches
6h 31m
1 stop
BUF3:06 pmBuffalo
Sep 1
BUF6:05 amBuffalo
5h 37m
1 stop
ECP10:42 amPanama City NW Florida Beaches
$407
Delta
Aug 27
ECP6:51 pmPanama City NW Florida Beaches
4h 08m
1 stop
BUF11:59 pmBuffalo
Aug 31
BUF7:59 pmBuffalo
15h 43m
2 stops
ECP10:42 amPanama City NW Florida Beaches
$481

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 5, 2026.
Use the filters below to find and compare flights from Panama City, Florida to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Thu 9/24

6:20 pm-11:54 pm

1 stop4h 34m

Buffalo

Mon 9/28

6:59 pm-11:25 pm

1 stop5h 26m

$341

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Tue 8/25

11:42 am-6:02 pm

1 stop5h 20m

Buffalo

Sun 8/30

5:22 am-11:29 am

1 stop7h 07m

$362

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Thu 7/30

11:00 am-6:43 pm

1 stop6h 43m

Buffalo

Wed 8/5

6:59 pm-10:40 pm

1 stop4h 41m

$372

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Sun 8/2

3:52 pm-11:59 pm

1 stop7h 07m

Buffalo

Sat 8/8

6:59 pm-10:40 pm

1 stop4h 41m

$374

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Tue 8/25

11:42 am-6:02 pm

1 stop5h 20m

Buffalo

Sun 8/30

5:22 am-1:50 pm

2 stops9h 28m

$377

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Tue 9/1

1:47 pm-9:07 pm

1 stop6h 20m

Buffalo

Wed 9/2

6:55 am-1:06 pm

1 stop7h 11m

$397

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Fri 8/28

7:35 am-3:06 pm

1 stop6h 31m

Buffalo

Tue 9/1

6:05 am-10:42 am

1 stop5h 37m

$407

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Fri 8/28

1:47 pm-9:07 pm

1 stop6h 20m

Buffalo

Mon 8/31

6:55 am-4:38 pm

2 stops10h 43m

$412

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Tue 9/1

1:47 pm-9:07 pm

1 stop6h 20m

Buffalo

Wed 9/2

6:55 am-1:06 pm

1 stop7h 11m

$421

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Sun 8/2

3:52 pm-11:59 pm

1 stop7h 07m

Buffalo

Sat 8/8

4:54 pm-10:40 pm

2 stops6h 46m

$422

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Panama City, Florida to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Panama City NW Florida Beaches to Buffalo?

Delta, American Airlines, and Southwest are the most popular carriers operating from Panama City NW Florida Beaches to Buffalo

When to book flights from Panama City, Florida to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Buffalo (ECP to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Buffalo

Fastest flight time

4h 34m

Direct flights

None
The fastest flight from Panama City, Florida to Buffalo takes 4h 34m
There are no direct flights from Panama City, Florida to Buffalo. There are no popular flight routes from Panama City, Florida to Buffalo.
Search flight deals

Frequently asked questions about flying from Panama City, Florida to Buffalo

  • How far is Panama City NW Florida Beaches to Buffalo by plane?

    Buffalo is 955.1 mi away from Panama City NW Florida Beaches. In terms of flight time, this usually takes a little over 4h 34m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Buffalo Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Buffalo Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Panama City, Florida to Buffalo?

Best airlines flying from Panama City, Florida to Buffalo

Compare and see reviews for airlines that fly from Panama City, Florida to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $236Free CancellationRating
7.1
11,779 reviews
Search American Airlines flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Williamsville
Orchard Park
Grand Island
Bowmansville
West Seneca
Lockport
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Buffalo?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Buffalo from Panama City.

Can I find flights from Panama City to Buffalo with flexible booking policies on momondo?

All flight searches from Panama City to Buffalo on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to Buffalo?

Once you have performed a search for Panama City to Buffalo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to Buffalo right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Buffalo from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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