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Cheap flights from Panama City, Florida to Buffalo from $178

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Buffalo departing on 6/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Panama City, Florida to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
4:17 pm - 10:52 pm
ECP
-
BUF
5h 35m
1 stop
American Airlines Logo
1:56 pm - 6:22 pm
BUF
-
ECP
5h 26m
1 stop
$355American Airlines
Wed, Jul 29 - Tue, Aug 4
Southwest Logo
7:40 am - 2:20 pm
ECP
-
BUF
5h 40m
1 stop
Southwest Logo
8:05 am - 3:00 pm
BUF
-
ECP
7h 55m
2 stops
$360Southwest
Wed, Jul 29 - Tue, Aug 4
Southwest Logo
7:40 am - 7:55 pm
ECP
-
BUF
11h 15m
2 stops
Southwest Logo
8:05 am - 3:00 pm
BUF
-
ECP
7h 55m
2 stops
$366Southwest
Wed, Jul 29 - Tue, Aug 4
Delta Logo
6:00 am - 11:13 am
ECP
-
BUF
4h 13m
1 stop
Delta Logo
4:55 pm - 10:51 pm
BUF
-
ECP
6h 56m
1 stop
$379Delta
Mon, Jun 1 - Wed, Jun 3
American Airlines Logo
3:48 pm - 9:24 pm
ECP
-
BUF
4h 36m
1 stop
American Airlines Logo
7:54 pm - 11:38 pm
BUF
-
ECP
4h 44m
1 stop
$393American Airlines
Sat, Aug 1 - Sat, Aug 8
American Airlines Logo
7:00 pm - 12:13 am
ECP
-
BUF
4h 13m
1 stop
American Airlines Logo
6:00 am - 2:12 pm
BUF
-
ECP
9h 12m
2 stops
$398American Airlines
Thu, Sep 17 - Mon, Sep 21
American Airlines Logo
1:17 pm - 7:12 pm
ECP
-
BUF
4h 55m
1 stop
American Airlines Logo
6:00 am - 10:27 am
BUF
-
ECP
5h 27m
1 stop
$400American Airlines
Fri, Jul 3 - Mon, Jul 6
American Airlines Logo
4:16 pm - 10:35 pm
ECP
-
BUF
5h 19m
1 stop
American Airlines Logo
5:33 am - 12:09 pm
BUF
-
ECP
7h 36m
1 stop
$407American Airlines
Fri, Jun 19 - Sun, Jun 21
American Airlines Logo
3:48 pm - 9:24 pm
ECP
-
BUF
4h 36m
1 stop
American Airlines Logo
7:54 pm - 11:38 pm
BUF
-
ECP
4h 44m
1 stop
$410American Airlines
Sat, Aug 1 - Sat, Aug 8
American Airlines Logo
4:16 pm - 11:52 pm
ECP
-
BUF
6h 36m
2 stops
American Airlines Logo
5:33 am - 12:09 pm
BUF
-
ECP
7h 36m
1 stop
$412American Airlines
Fri, Jun 19 - Sun, Jun 21

Delta flights from Panama City, Florida to Buffalo

Our best Delta deals on Panama City, Florida to Buffalo flight tickets
Delta
Jun 1
ECP6:00 amPanama City NW Florida Beaches
4h 13m
1 stop
BUF11:13 amBuffalo
Jun 3
BUF4:55 pmBuffalo
6h 56m
1 stop
ECP10:51 pmPanama City NW Florida Beaches
$379
Delta
Jun 1
ECP6:45 pmPanama City NW Florida Beaches
4h 14m
1 stop
BUF11:59 pmBuffalo
Jun 3
BUF6:15 amBuffalo
5h 36m
1 stop
ECP10:51 amPanama City NW Florida Beaches
$421
Delta
Jun 19
ECP6:45 pmPanama City NW Florida Beaches
4h 14m
1 stop
BUF11:59 pmBuffalo
Jun 22
BUF6:00 amBuffalo
5h 54m
1 stop
ECP10:54 amPanama City NW Florida Beaches
$491

Southwest flights from Panama City, Florida to Buffalo

Our best Southwest deals on Panama City, Florida to Buffalo flight tickets
Southwest
Jul 29
ECP7:40 amPanama City NW Florida Beaches
5h 40m
1 stop
BUF2:20 pmBuffalo
Aug 4
BUF8:05 amBuffalo
7h 55m
2 stops
ECP3:00 pmPanama City NW Florida Beaches
$360
Southwest
Jul 29
ECP7:40 amPanama City NW Florida Beaches
11h 15m
2 stops
BUF7:55 pmBuffalo
Aug 4
BUF8:05 amBuffalo
7h 55m
2 stops
ECP3:00 pmPanama City NW Florida Beaches
$366
Southwest
Jun 19
ECP7:50 amPanama City NW Florida Beaches
7h 10m
1 stop
BUF4:00 pmBuffalo
Jun 21
BUF7:20 amBuffalo
7h 20m
1 stop
ECP1:40 pmPanama City NW Florida Beaches
$417

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 15, 2026.
Use the filters below to find and compare flights from Panama City, Florida to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Wed 7/29

4:17 pm-10:52 pm

1 stop5h 35m

Buffalo

Tue 8/4

1:56 pm-6:22 pm

1 stop5h 26m

$355

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Wed 7/29

7:40 am-2:20 pm

1 stop5h 40m

Buffalo

Tue 8/4

8:05 am-3:00 pm

2 stops7h 55m

$360

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Wed 7/29

7:40 am-7:55 pm

2 stops11h 15m

Buffalo

Tue 8/4

8:05 am-3:00 pm

2 stops7h 55m

$366

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Mon 6/1

6:00 am-11:13 am

1 stop4h 13m

Buffalo

Wed 6/3

4:55 pm-10:51 pm

1 stop6h 56m

$379
Quickest round-trip

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Sat 8/1

3:48 pm-9:24 pm

1 stop4h 36m

Buffalo

Sat 8/8

7:54 pm-11:38 pm

1 stop4h 44m

$393

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Thu 9/17

7:00 pm-12:13 am

1 stop4h 13m

Buffalo

Mon 9/21

6:00 am-2:12 pm

2 stops9h 12m

$398

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Fri 7/3

1:17 pm-7:12 pm

1 stop4h 55m

Buffalo

Mon 7/6

6:00 am-10:27 am

1 stop5h 27m

$400

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Fri 6/19

4:16 pm-10:35 pm

1 stop5h 19m

Buffalo

Sun 6/21

5:33 am-12:09 pm

1 stop7h 36m

$407

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Sat 8/1

3:48 pm-9:24 pm

1 stop4h 36m

Buffalo

Sat 8/8

7:54 pm-11:38 pm

1 stop4h 44m

$410

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Fri 6/19

4:16 pm-11:52 pm

2 stops6h 36m

Buffalo

Sun 6/21

5:33 am-12:09 pm

1 stop7h 36m

$412

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Panama City, Florida to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of November, then book flights to Buffalo from Panama City, Florida during January instead. Flights to Buffalo in January, while not as cheap as those in November, still average around $0.

When to book flights from Panama City, Florida to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Buffalo (ECP to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Buffalo

Fastest flight time

4h 13m

Direct flights

None
The fastest flight from Panama City, Florida to Buffalo takes 4h 13m
There are no direct flights from Panama City, Florida to Buffalo. There are no popular flight routes from Panama City, Florida to Buffalo.
Search flight deals

Frequently asked questions about flying from Panama City, Florida to Buffalo

  • How far is Panama City NW Florida Beaches to Buffalo by plane?

    Buffalo is 955.1 mi away from Panama City NW Florida Beaches. In terms of flight time, this usually takes a little over 4h 13m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Buffalo Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Buffalo Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Panama City, Florida to Buffalo?

Best airlines flying from Panama City, Florida to Buffalo

Compare and see reviews for airlines that fly from Panama City, Florida to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $236Free CancellationRating
7.1
11,662 reviews
Search American Airlines flights
DeltaPriceFrom $318Free CancellationRating
7.9
8,453 reviews
Search Delta flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Grand Island
Williamsville
Orchard Park
Bowmansville
West Seneca
Lockport
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Buffalo?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Buffalo from Panama City.

Can I find flights from Panama City to Buffalo with flexible booking policies on momondo?

All flight searches from Panama City to Buffalo on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to Buffalo?

Once you have performed a search for Panama City to Buffalo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to Buffalo right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Buffalo from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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