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Cheap flights from Panama City, Florida to Buffalo from $307

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Buffalo departing on 9/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Panama City, Florida to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
11:42 am - 6:02 pmECP  Panama City NW Florida Beaches-BUF Buffalo
5h 20m1 stop Charlotte Douglas
American Airlines Logo
12:56 pm - 5:32 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
5h 36m1 stop Charlotte Douglas
$307American Airlines
Fri, Sep 4 - Wed, Sep 9
Delta Logo
5:30 pm - 11:52 pmECP  Panama City NW Florida Beaches-BUF Buffalo
5h 22m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:59 pm - 11:05 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
5h 06m1 stop Atlanta Hartsfield-Jackson
$325Delta
Fri, Sep 11 - Wed, Sep 16
American Airlines Logo
11:42 am - 6:02 pmECP  Panama City NW Florida Beaches-BUF Buffalo
5h 20m1 stop Charlotte Douglas
American Airlines Logo
12:56 pm - 5:32 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
5h 36m1 stop Charlotte Douglas
$338American Airlines
Fri, Sep 4 - Wed, Sep 9
Delta Logo
5:30 pm - 11:52 pmECP  Panama City NW Florida Beaches-BUF Buffalo
5h 22m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:59 pm - 11:05 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
5h 06m1 stop Atlanta Hartsfield-Jackson
$338Delta
Fri, Sep 11 - Wed, Sep 16
Delta Logo
11:19 am - 5:52 pmECP  Panama City NW Florida Beaches-BUF Buffalo
5h 33m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:59 pm - 11:25 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
5h 26m1 stop Atlanta Hartsfield-Jackson
$338Delta
Wed, Sep 30 - Fri, Oct 2
American Airlines Logo
1:15 pm - 9:48 pmECP  Panama City NW Florida Beaches-BUF Buffalo
7h 33m2 stops Philadelphia Boston Logan Intl
American Airlines Logo
12:56 pm - 5:32 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
5h 36m1 stop Charlotte Douglas
$359American Airlines
Fri, Sep 4 - Wed, Sep 9
American Airlines Logo
11:42 am - 6:02 pmECP  Panama City NW Florida Beaches-BUF Buffalo
5h 20m1 stop Charlotte Douglas
American Airlines Logo
12:56 pm - 5:32 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
5h 36m1 stop Charlotte Douglas
$368American Airlines
Fri, Sep 4 - Fri, Sep 11
Southwest Logo
9:30 am - 5:40 pmECP  Panama City NW Florida Beaches-BUF Buffalo
7h 10m1 stop Baltimore/Washington
Southwest Logo
5:45 am - 1:55 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
9h 10m1 stop Baltimore/Washington
$377Southwest
Sat, Sep 5 - Sat, Sep 12
Southwest Logo
7:45 am - 4:00 pmECP  Panama City NW Florida Beaches-BUF Buffalo
7h 15m1 stop Nashville Intl
Southwest Logo
10:50 am - 6:10 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
8h 20m2 stops Baltimore/Washington Lambert-St Louis
$377Southwest
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
1:32 pm - 9:47 pmECP  Panama City NW Florida Beaches-BUF Buffalo
7h 15m1 stop Charlotte Douglas
American Airlines Logo
11:31 am - 6:08 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
7h 37m1 stop Charlotte Douglas
$381American Airlines
Fri, Sep 11 - Sun, Sep 13

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Delta flights from Panama City, Florida to Buffalo

Our best Delta deals on Panama City, Florida to Buffalo flight tickets
Delta
Sep 11
ECP5:30 pmPanama City NW Florida Beaches
5h 22m
1 stop
BUF11:52 pmBuffalo
Sep 16
BUF6:59 pmBuffalo
5h 06m
1 stop
ECP11:05 pmPanama City NW Florida Beaches
$325
Delta
Sep 14
ECP6:00 amPanama City NW Florida Beaches
4h 10m
1 stop
BUF11:10 amBuffalo
Sep 18
BUF3:51 pmBuffalo
6h 12m
1 stop
ECP9:03 pmPanama City NW Florida Beaches
$455
Delta
Sep 14
ECP6:00 amPanama City NW Florida Beaches
4h 10m
1 stop
BUF11:10 amBuffalo
Sep 18
BUF3:51 pmBuffalo
6h 12m
1 stop
ECP9:03 pmPanama City NW Florida Beaches
$501

Southwest flights from Panama City, Florida to Buffalo

Our best Southwest deals on Panama City, Florida to Buffalo flight tickets
Southwest
Sep 5
ECP9:30 amPanama City NW Florida Beaches
7h 10m
1 stop
BUF5:40 pmBuffalo
Sep 12
BUF5:45 amBuffalo
9h 10m
1 stop
ECP1:55 pmPanama City NW Florida Beaches
$377
Southwest
Sep 5
ECP10:40 amPanama City NW Florida Beaches
6h 05m
2 stops
BUF5:45 pmBuffalo
Sep 12
BUF10:50 amBuffalo
8h 20m
2 stops
ECP6:10 pmPanama City NW Florida Beaches
$382
Southwest
Sep 30
ECP11:30 amPanama City NW Florida Beaches
9h 20m
2 stops
BUF9:50 pmBuffalo
Oct 2
BUF2:20 pmBuffalo
8h 50m
2 stops
ECP10:10 pmPanama City NW Florida Beaches
$394

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 17, 2026.
Use the filters below to find and compare flights from Panama City, Florida to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityBuffalo

ECP Panama City NW Florida Beaches - BUF Buffalo

ECPBUF

Panama City NW Florida Beaches

Fri 9/4

11:42 am-6:02 pm

1 stop5h 20m

Buffalo

Wed 9/9

12:56 pm-5:32 pm

1 stop5h 36m

$307
Quickest round-trip

Panama CityBuffalo

ECP Panama City NW Florida Beaches - BUF Buffalo

ECPBUF

Panama City NW Florida Beaches

Fri 9/11

5:30 pm-11:52 pm

1 stop5h 22m

Buffalo

Wed 9/16

6:59 pm-11:05 pm

1 stop5h 06m

$325

Panama CityBuffalo

ECP Panama City NW Florida Beaches - BUF Buffalo

ECPBUF

Panama City NW Florida Beaches

Fri 9/4

11:42 am-6:02 pm

1 stop5h 20m

Buffalo

Wed 9/9

12:56 pm-5:32 pm

1 stop5h 36m

$338

Panama CityBuffalo

ECP Panama City NW Florida Beaches - BUF Buffalo

ECPBUF

Panama City NW Florida Beaches

Fri 9/11

5:30 pm-11:52 pm

1 stop5h 22m

Buffalo

Wed 9/16

6:59 pm-11:05 pm

1 stop5h 06m

$338

Panama CityBuffalo

ECP Panama City NW Florida Beaches - BUF Buffalo

ECPBUF

Panama City NW Florida Beaches

Wed 9/30

11:19 am-5:52 pm

1 stop5h 33m

Buffalo

Fri 10/2

6:59 pm-11:25 pm

1 stop5h 26m

$338

Panama CityBuffalo

ECP Panama City NW Florida Beaches - BUF Buffalo

ECPBUF

Panama City NW Florida Beaches

Fri 9/4

1:15 pm-9:48 pm

2 stops7h 33m

Buffalo

Wed 9/9

12:56 pm-5:32 pm

1 stop5h 36m

$359

Panama CityBuffalo

ECP Panama City NW Florida Beaches - BUF Buffalo

ECPBUF

Panama City NW Florida Beaches

Fri 9/4

11:42 am-6:02 pm

1 stop5h 20m

Buffalo

Fri 9/11

12:56 pm-5:32 pm

1 stop5h 36m

$368

Panama CityBuffalo

ECP Panama City NW Florida Beaches - BUF Buffalo

ECPBUF

Panama City NW Florida Beaches

Sat 9/5

9:30 am-5:40 pm

1 stop7h 10m

Buffalo

Sat 9/12

5:45 am-1:55 pm

1 stop9h 10m

$377

Panama CityBuffalo

ECP Panama City NW Florida Beaches - BUF Buffalo

ECPBUF

Panama City NW Florida Beaches

Sat 9/5

7:45 am-4:00 pm

1 stop7h 15m

Buffalo

Sat 9/12

10:50 am-6:10 pm

2 stops8h 20m

$377

Panama CityBuffalo

ECP Panama City NW Florida Beaches - BUF Buffalo

ECPBUF

Panama City NW Florida Beaches

Fri 9/11

1:32 pm-9:47 pm

1 stop7h 15m

Buffalo

Sun 9/13

11:31 am-6:08 pm

1 stop7h 37m

$381

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Panama City, Florida to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Panama City NW Florida Beaches to Buffalo?

Southwest, American Airlines, and Delta are the most popular carriers operating from Panama City NW Florida Beaches to Buffalo

When to book flights from Panama City, Florida to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Buffalo (ECP to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Buffalo

Best Price Found

$346

Fastest flight time

4h 08m

Direct flights

None
The best one-way flight to Buffalo from Panama City, Florida in the past 72 hours is $346. The best round-trip flight deal from Panama City, Florida to Buffalo found on momondo in the last 72 hours is $307.
The fastest flight from Panama City, Florida to Buffalo takes 4h 08m
There are no direct flights from Panama City, Florida to Buffalo. There are no popular flight routes from Panama City, Florida to Buffalo.
Search flight deals

Frequently asked questions about flying from Panama City, Florida to Buffalo

  • How far is Panama City NW Florida Beaches to Buffalo by plane?

    Buffalo is 955.1 mi away from Panama City NW Florida Beaches. In terms of flight time, this usually takes a little over 4h 08m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Buffalo Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Buffalo Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Panama City, Florida to Buffalo?

Best airlines flying from Panama City, Florida to Buffalo

Compare and see reviews for airlines that fly from Panama City, Florida to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $366Free CancellationRating
7.1
11,945 reviews
Search American Airlines flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Williamsville
Orchard Park
Grand Island
Bowmansville
Lockport
West Seneca
East Aurora
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Buffalo?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Buffalo from Panama City.

Can I find flights from Panama City to Buffalo with flexible booking policies on momondo?

All flight searches from Panama City to Buffalo on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to Buffalo?

Once you have performed a search for Panama City to Buffalo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to Buffalo right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Buffalo from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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