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Cheap flights from Panama City, Florida to Buffalo from $128

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City, Florida to Buffalo departing on 12/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Panama City, Florida to Buffalo (ECP-BUF)

Cheap round-trip flights

Delta Logo
6:00 am - 11:16 amECP-BUF
4h 16m1 stop
Delta Logo
6:50 pm - 10:42 pmBUF-ECP
4h 52m1 stop
$263Delta
Find Deal
Wed, Feb 18 - Sat, Feb 21
Delta Logo
6:00 am - 5:26 pmECP-BUF
10h 26m2 stops
Delta Logo
6:50 pm - 10:42 pmBUF-ECP
4h 52m1 stop
$268Delta
Find Deal
Wed, Feb 18 - Sat, Feb 21
Delta Logo
7:45 am - 5:07 pmECP-BUF
8h 22m2 stops
Delta Logo
5:55 pm - 10:42 pmBUF-ECP
5h 47m2 stops
$273Delta
Find Deal
Wed, Feb 18 - Sat, Feb 21
Delta Logo
6:00 am - 11:01 amECP-BUF
4h 01m1 stop
Delta Logo
5:14 pm - 11:10 pmBUF-ECP
6h 56m1 stop
$325Delta
Find Deal
Mon, Oct 27 - Sat, Nov 1
American Airlines Logo
5:55 pm - 11:26 pmECP-BUF
4h 31m1 stop
American Airlines Logo
6:32 am - 11:29 amBUF-ECP
5h 57m1 stop
$350American Airlines
Find Deal
Fri, Nov 14 - Mon, Nov 17
United Airlines Logo
11:10 am - 10:42 pmECP-BUF
10h 32m2 stops
United Airlines Logo
7:07 am - 1:10 pmBUF-ECP
7h 03m1 stop
$377United Airlines
Find Deal
Fri, Oct 3 - Sun, Oct 5
Southwest Logo
1:30 pm - 11:40 pmECP-BUF
9h 10m2 stops
Southwest Logo
1:50 pm - 7:05 pmBUF-ECP
6h 15m1 stop
$411Southwest
Find Deal
Fri, Nov 14 - Mon, Nov 17
Southwest Logo
7:40 am - 3:15 pmECP-BUF
6h 35m1 stop
Southwest Logo
6:10 am - 10:20 amBUF-ECP
5h 10m1 stop
$447Southwest
Find Deal
Tue, Sep 16 - Sat, Sep 20
United Airlines Logo
1:44 pm - 9:16 pmECP-BUF
6h 32m1 stop
United Airlines Logo
10:55 am - 8:16 pmBUF-ECP
10h 21m2 stops
$452United Airlines
Find Deal
Tue, Sep 16 - Sat, Sep 20
American Airlines Logo
6:59 pm - 12:12 amECP-BUF
4h 13m1 stop
American Airlines Logo
6:00 am - 2:20 pmBUF-ECP
9h 20m2 stops
$535American Airlines
Find Deal
Thu, Sep 25 - Mon, Sep 29

Delta flights from Panama City, Florida to Buffalo

Our best Delta deals on Panama City, Florida to Buffalo flight tickets
Delta
Feb 18
ECP6:00 amPanama City NW Florida Beaches
4h 16m
1 stop
BUF11:16 amBuffalo
Feb 21
BUF6:50 pmBuffalo
4h 52m
1 stop
ECP10:42 pmPanama City NW Florida Beaches
$263
Find similar
Delta
Feb 18
ECP6:00 amPanama City NW Florida Beaches
10h 26m
2 stops
BUF5:26 pmBuffalo
Feb 21
BUF6:50 pmBuffalo
4h 52m
1 stop
ECP10:42 pmPanama City NW Florida Beaches
$268
Find similar
Delta
Feb 18
ECP7:45 amPanama City NW Florida Beaches
8h 22m
2 stops
BUF5:07 pmBuffalo
Feb 21
BUF5:55 pmBuffalo
5h 47m
2 stops
ECP10:42 pmPanama City NW Florida Beaches
$273
Find similar

American Airlines flights from Panama City, Florida to Buffalo

Our best American Airlines deals on Panama City, Florida to Buffalo flight tickets
American Airlines
Nov 14
ECP5:55 pmPanama City NW Florida Beaches
4h 31m
1 stop
BUF11:26 pmBuffalo
Nov 17
BUF6:32 amBuffalo
5h 57m
1 stop
ECP11:29 amPanama City NW Florida Beaches
$350
Find similar
American Airlines
Sep 25
ECP6:59 pmPanama City NW Florida Beaches
4h 13m
1 stop
BUF12:12 amBuffalo
Sep 29
BUF6:00 amBuffalo
9h 20m
2 stops
ECP2:20 pmPanama City NW Florida Beaches
$535
Find similar
American Airlines
Sep 25
ECP6:59 pmPanama City NW Florida Beaches
4h 13m
1 stop
BUF12:12 amBuffalo
Sep 29
BUF10:12 amBuffalo
8h 24m
2 stops
ECP5:36 pmPanama City NW Florida Beaches
$604
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Panama City, Florida to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 4, 2025.
Use the filters below to find and compare flights from Panama City, Florida to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Wed 2/18

6:00 am-11:16 am

1 stop4h 16m

Buffalo

Sat 2/21

6:50 pm-10:42 pm

1 stop4h 52m

$263

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Wed 2/18

6:00 am-5:26 pm

2 stops10h 26m

Buffalo

Sat 2/21

6:50 pm-10:42 pm

1 stop4h 52m

$268

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Wed 2/18

7:45 am-5:07 pm

2 stops8h 22m

Buffalo

Sat 2/21

5:55 pm-10:42 pm

2 stops5h 47m

$273

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Mon 10/27

6:00 am-11:01 am

1 stop4h 01m

Buffalo

Sat 11/1

5:14 pm-11:10 pm

1 stop6h 56m

$325

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Fri 11/14

5:55 pm-11:26 pm

1 stop4h 31m

Buffalo

Mon 11/17

6:32 am-11:29 am

1 stop5h 57m

$350

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Fri 10/3

11:10 am-10:42 pm

2 stops10h 32m

Buffalo

Sun 10/5

7:07 am-1:10 pm

1 stop7h 03m

$377

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Fri 11/14

1:30 pm-11:40 pm

2 stops9h 10m

Buffalo

Mon 11/17

1:50 pm-7:05 pm

1 stop6h 15m

$411

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Tue 9/16

7:40 am-3:15 pm

1 stop6h 35m

Buffalo

Sat 9/20

6:10 am-10:20 am

1 stop5h 10m

$447

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Tue 9/16

1:44 pm-9:16 pm

1 stop6h 32m

Buffalo

Sat 9/20

10:55 am-8:16 pm

2 stops10h 21m

$452

Panama CityBuffalo

ECP - BUF

ECPBUF

Panama City NW Florida Beaches

Thu 9/25

6:59 pm-12:12 am

1 stop4h 13m

Buffalo

Mon 9/29

6:00 am-2:20 pm

2 stops9h 20m

$535

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Panama City, Florida to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of September, then book flights to Buffalo from Panama City, Florida during October instead. Flights to Buffalo in October, while not as cheap as those in September, still average around $306.

What is the cheapest day to depart on your flight to Buffalo?

Our data shows that Tuesday is the least expensive day to fly to Buffalo. Tickets to fly out on this day can be as low as $296. Flights from Panama City, Florida to Buffalo on a Monday will generally be more expensive and average around $532. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

When to book flights from Panama City, Florida to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City, Florida to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City, Florida to Buffalo (ECP to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City, Florida to Buffalo

Direct flights

None
There are no direct flights from Panama City, Florida to Buffalo. There are no popular flight routes from Panama City, Florida to Buffalo.
Search flight deals

  • How far is Panama City NW Florida Beaches to Buffalo by plane?

    Buffalo is 955.1 mi away from Panama City NW Florida Beaches. In terms of flight time, this usually takes a little over 3h 50m.

  • When did momondo last update prices for flights from Panama City NW Florida Beaches Airport to Buffalo Airport?

    Prices for flights from Panama City NW Florida Beaches Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Panama City NW Florida Beaches Airport to Buffalo Airport?

  • How old do you have to be to fly from Panama City NW Florida Beaches Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City NW Florida Beaches Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Panama City, Florida to Buffalo?

Best airlines flying from Panama City, Florida to Buffalo

Compare and see reviews for airlines that fly from Panama City, Florida to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $172Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $286Free CancellationRating
7.9
7,977 reviews
Search Delta flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Tonawanda
Williamsville
Amherst
Grand Island
Lockport
Orchard Park
West Seneca
East Aurora
Eden
Angola
Bowmansville

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Buffalo?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Buffalo from Panama City.

Can I find flights from Panama City to Buffalo with flexible booking policies on momondo?

All flight searches from Panama City to Buffalo on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Panama City to Buffalo?

Once you have performed a search for Panama City to Buffalo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Panama City to Buffalo right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Buffalo from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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