What is the cheapest airline that flies from Chicago O'Hare Intl to South Carolina?

Spirit Airlines, Frontier, and United Airlines are the most popular carriers operating from Chicago O'Hare Intl to South Carolina

How many flights depart from Chicago O'Hare Intl Airport to South Carolina on average per day?

The number of flights available between Chicago O'Hare Intl Airport and South Carolina is 92 per day as of December 2025. The most frequent departure time is 5:00PM, with 50% of daily flights leaving in the afternoon.

What airlines fly to South Carolina?

American Airlines, United Airlines and Spirit Airlines are the top three most popular airlines that fly to South Carolina from Chicago O'Hare Intl Airport according to our data. American Airlines is the first choice among our users, with 49% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 5 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

How many operators does momondo search for flights from Chicago O'Hare Intl Airport to South Carolina?

There are 6 operators available for flights from Chicago O'Hare Intl Airport to South Carolina as of December 2025.

How old do you have to be to fly from Chicago O'Hare Intl Airport to South Carolina?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Chicago O'Hare Intl Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents you'll need for your trip to South Carolina may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South Carolina. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$33 Cheap Flights from Chicago O'Hare Intl Airport to South Carolina in 2025/26

Q: How many flights depart from Chicago O'Hare Intl Airport to South Carolina on average per week?

As of December 2025, 644 flights take off from Chicago O'Hare Intl Airport and land in South Carolina each week. The most common flight departure day for this route is Thu, with 16% of weekly flights taking off on this day.

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Find the cheapest flights from Chicago O'Hare Intl Airport to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

4:19 pm - 7:25 pm

ORD

CLT

2h 06mnonstop

8:20 pm - 9:42 pm

CLT

ORD

2h 22mnonstop

$63Frontier

Thu, Feb 5 - Mon, Feb 9

4:19 pm - 7:25 pm

ORD

CLT

2h 06mnonstop

8:20 pm - 9:42 pm

CLT

ORD

2h 22mnonstop

$64Frontier

Thu, Feb 5 - Mon, Feb 9

7:20 am - 7:20 pm

ORD

MYR

11h 00m1 stop

1:07 pm - 7:41 pm

MYR

ORD

7h 34m1 stop

$174Spirit Airlines

Thu, Jan 15 - Sat, Jan 17

6:05 am - 12:12 pm

ORD

MYR

5h 07m1 stop

1:07 pm - 5:52 pm

MYR

ORD

5h 45m1 stop

$176Spirit Airlines

Tue, Jan 27 - Thu, Jan 29

5:50 pm - 8:47 pm

ORD

GSP

1h 57mnonstop

6:35 am - 7:56 am

GSP

ORD

2h 21mnonstop

$202United Airlines

Wed, Jan 7 - Sun, Jan 11

5:50 pm - 8:47 pm

ORD

GSP

1h 57mnonstop

10:00 am - 2:25 pm

GSP

ORD

5h 25m1 stop

$205United Airlines

Sat, Jan 17 - Tue, Jan 20

3:48 pm - 10:32 pm

ORD

CAE

5h 44m1 stop

6:00 am - 10:52 am

CAE

ORD

5h 52m1 stop

$229American Airlines

Fri, Jan 16 - Mon, Jan 19

8:50 pm - 12:20 pm

ORD

HHH

14h 30m2 stops

12:51 pm - 6:01 pm

HHH

ORD

6h 10m1 stop

$293American Airlines

Sat, Jan 17 - Tue, Jan 20

5:25 am - 10:55 am

ORD

AGS

4h 30m1 stop

10:14 am - 2:10 pm

AGS

ORD

4h 56m1 stop

$362Delta

Sun, Feb 22 - Sat, Feb 28

6:45 am - 12:06 pm

ORD

AGS

4h 21m1 stop

8:00 am - 1:39 pm

AGS

ORD

6h 39m1 stop

$376Delta

Fri, Jan 2 - Sat, Jan 10

Frontier flights from Chicago O'Hare Intl Airport to South Carolina

Our best Frontier deals on Chicago O'Hare Intl Airport to South Carolina flight tickets

Frontier

Feb 5

ORD4:19 pmChicago O'Hare Intl

2h 06m

CLT7:25 pmCharlotte Douglas

Feb 9

CLT8:20 pmCharlotte Douglas

2h 22m

ORD9:42 pmChicago O'Hare Intl

$63

Find similar

Frontier

Jan 8

ORD11:53 amChicago O'Hare Intl

2h 07m

CLT3:00 pmCharlotte Douglas

Jan 15

CLT2:05 pmCharlotte Douglas

2h 22m

ORD3:27 pmChicago O'Hare Intl

$66

Find similar

Frontier

Jan 16

ORD9:00 amChicago O'Hare Intl

2h 06m

CLT12:06 pmCharlotte Douglas

Jan 19

CLT12:30 pmCharlotte Douglas

2h 22m

ORD1:52 pmChicago O'Hare Intl

$67

Find similar

Spirit Airlines flights from Chicago O'Hare Intl Airport to South Carolina

Our best Spirit Airlines deals on Chicago O'Hare Intl Airport to South Carolina flight tickets

Spirit Airlines

Feb 7

ORD4:38 pmChicago O'Hare Intl

6h 21m

1 stop

CLT11:59 pmCharlotte Douglas

Feb 21

CLT1:24 pmCharlotte Douglas

8h 32m

1 stop

ORD8:56 pmChicago O'Hare Intl

$138

Find similar

Spirit Airlines

Jan 12

ORD8:43 pmChicago O'Hare Intl

13h 12m

1 stop

CLT10:55 amCharlotte Douglas

Jan 14

CLT6:00 amCharlotte Douglas

6h 22m

1 stop

ORD11:22 amChicago O'Hare Intl

$140

Find similar

Spirit Airlines

Jan 16

ORD4:38 pmChicago O'Hare Intl

21h 04m

1 stop

MYR2:42 pmMyrtle Beach Intl

Jan 20

MYR10:00 amMyrtle Beach Intl

24h 12m

1 stop

ORD9:12 amChicago O'Hare Intl

$162

Find similar

momondo Fare Finder

Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Thu 2/5

4:19 pm-7:25 pm

Nonstop2h 06m

Charlotte Douglas

Mon 2/9

8:20 pm-9:42 pm

Nonstop2h 22m

$63

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Thu 2/5

4:19 pm-7:25 pm

Nonstop2h 06m

Charlotte Douglas

Mon 2/9

8:20 pm-9:42 pm

Nonstop2h 22m

$64

ChicagoMyrtle Beach

ORD - MYR

ORDMYR

Chicago O'Hare Intl

Thu 1/15

7:20 am-7:20 pm

1 stop11h 00m

Myrtle Beach Intl

Sat 1/17

1:07 pm-7:41 pm

1 stop7h 34m

$174

ChicagoMyrtle Beach

ORD - MYR

ORDMYR

Chicago O'Hare Intl

Tue 1/27

6:05 am-12:12 pm

1 stop5h 07m

Myrtle Beach Intl

Thu 1/29

1:07 pm-5:52 pm

1 stop5h 45m

$176

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Wed 1/7

5:50 pm-8:47 pm

Nonstop1h 57m

Greenville

Sun 1/11

6:35 am-7:56 am

Nonstop2h 21m

$202

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Sat 1/17

5:50 pm-8:47 pm

Nonstop1h 57m

Greenville

Tue 1/20

10:00 am-2:25 pm

1 stop5h 25m

$205

ChicagoColumbia

ORD - CAE

ORDCAE

Chicago O'Hare Intl

Fri 1/16

3:48 pm-10:32 pm

1 stop5h 44m

Columbia Metropolitan

Mon 1/19

6:00 am-10:52 am

1 stop5h 52m

$229

ChicagoHilton Head Island

ORD - HHH

ORDHHH

Chicago O'Hare Intl

Sat 1/17

8:50 pm-12:20 pm

2 stops14h 30m

Hilton Head Island

Tue 1/20

12:51 pm-6:01 pm

1 stop6h 10m

$293

ChicagoAugusta

ORD - AGS

ORDAGS

Chicago O'Hare Intl

Sun 2/22

5:25 am-10:55 am

1 stop4h 30m

Augusta Bush Field

Sat 2/28

10:14 am-2:10 pm

1 stop4h 56m

$362

ChicagoAugusta

ORD - AGS

ORDAGS

Chicago O'Hare Intl

Fri 1/2

6:45 am-12:06 pm

1 stop4h 21m

Augusta Bush Field

Sat 1/10

8:00 am-1:39 pm

1 stop6h 39m

$376

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Chicago O'Hare Intl Airport is in August. Flight prices, which tend to average around $326, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of August, then book flights to South Carolina from Chicago O'Hare Intl Airport during September instead. Flights to South Carolina in September, while not as cheap as those in August, still average around $327.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Tuesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $356. The most expensive day to fly to South Carolina is Friday, with ticket prices averaging around $397.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Chicago O'Hare Intl Airport to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $363. Try not to purchase tickets in the morning because they tend to be around $388. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Chicago O'Hare Intl to South Carolina flight route?

Fly from Chicago O'Hare Intl to Greenville for the best Chicago O'Hare Intl - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Chicago O'Hare Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $380 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Chicago O'Hare Intl Airport for as low as $322 on momondo.

What cabin class options are available on Chicago O'Hare Intl to South Carolina flights?

There are 4 cabin classes available to choose from on Chicago O'Hare Intl to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago O'Hare Intl Airport to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Chicago O'Hare Intl Airport to South Carolina.

Cheap Chicago O'Hare Intl Airport to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to South Carolina

Best Price Found	$167
Fastest flight time	1h 55m
Direct flights	Every day
Airports in South Carolina	57 airports

The best one-way flight to South Carolina from Chicago O'Hare Intl Airport in the past 72 hours is $167. The best round-trip flight deal from Chicago O'Hare Intl Airport to South Carolina found on momondo in the last 72 hours is $246.

The fastest flight from Chicago O'Hare Intl Airport to South Carolina takes 1h 55m

Direct flights go from Chicago O'Hare Intl Airport to South Carolina every day.

There are 57 airports in South Carolina. From Chicago O'Hare Intl Airport there are direct flights to Greenville (GSP), Myrtle Beach Intl (MYR), Charlotte Douglas (CLT).

Search flight deals

When did momondo last update prices for flights from Chicago O'Hare Intl Airport to South Carolina?
Prices for flights from Chicago O'Hare Intl Airport to South Carolina were last updated today.
How many operators does momondo search for flights from Chicago O'Hare Intl Airport to South Carolina?
There are 6 operators available for flights from Chicago O'Hare Intl Airport to South Carolina as of December 2025.
How old do you have to be to fly from Chicago O'Hare Intl Airport to South Carolina?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Chicago O'Hare Intl Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents you'll need for your trip to South Carolina may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South Carolina. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular plane model from Chicago O'Hare Intl Airport to South Carolina?
momondo data reveals that the most frequently booked plane model on the route from Chicago O'Hare Intl Airport to South Carolina is Embraer 175 (Enhanced Winglets), representing 20.12% of all bookings. The subsequent popular models are Embraer 175 at 16.98%, Embraer 170 at 14.28%, and Airbus A319 at 10.81%.

Best airlines flying from Chicago O'Hare Intl Airport to South Carolina

Compare and see reviews for airlines that fly from Chicago O'Hare Intl Airport to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Spirit Airlines	PriceFrom $64	Free Cancellation	Rating 6.3 8,179 reviews	Search Spirit Airlines flights
Delta	PriceFrom $148	Free Cancellation	Rating 7.9 8,008 reviews	Search Delta flights
United Airlines	PriceFrom $188	Free Cancellation	Rating 7.4 9,095 reviews	Search United Airlines flights
American Airlines	PriceFrom $202	Free Cancellation	Rating 7.2 11,050 reviews	Search American Airlines flights
Southwest	PriceFrom $210	Free Cancellation	Rating 7.9 4,253 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Chicago to South Carolina for you.

Can I find flights from Chicago to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Chicago to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Chicago to South Carolina?

momondo helps you find the best flight between Chicago and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Chicago to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Chicago to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your South Carolina trip

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Chicago O'Hare Intl Airport flight routes

Flights from Chicago O'Hare Intl to Baltimore/Washington

Flights from Chicago O'Hare Intl to Minneapolis St Paul

Flights from Chicago O'Hare Intl to Atlanta Hartsfield-Jackson

Flights from Chicago O'Hare Intl to New York John F Kennedy Intl

Flights from Chicago O'Hare Intl to Austin Bergstrom

Flights from Chicago O'Hare Intl to Tweed-New Haven

Cheap flights from Chicago O'Hare Intl Airport to South Carolina from $33

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Find the cheapest flights from Chicago O'Hare Intl Airport to South Carolina

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Frontier flights from Chicago O'Hare Intl Airport to South Carolina

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Spirit Airlines flights from Chicago O'Hare Intl Airport to South Carolina

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momondo Fare Finder

Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to South Carolina that are best for you.

See travel insights to South Carolina from

How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to South Carolina

What is the cheapest month to fly to South Carolina?

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Tuesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $356. The most expensive day to fly to South Carolina is Friday, with ticket prices averaging around $397.

What is the cheapest time of day to depart on your flight to South Carolina?

What is the cheapest Chicago O'Hare Intl to South Carolina flight route?

Fly from Chicago O'Hare Intl to Greenville for the best Chicago O'Hare Intl - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

What cabin class options are available on Chicago O'Hare Intl to South Carolina flights?

There are 4 cabin classes available to choose from on Chicago O'Hare Intl to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago O'Hare Intl Airport to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Chicago O'Hare Intl Airport to South Carolina.

What is the cheapest airline that flies from Chicago O'Hare Intl to South Carolina?

Spirit Airlines, Frontier, and United Airlines are the most popular carriers operating from Chicago O'Hare Intl to South Carolina

What airlines fly to South Carolina?

How many flights depart from Chicago O'Hare Intl Airport to South Carolina on average per day?

The number of flights available between Chicago O'Hare Intl Airport and South Carolina is 92 per day as of December 2025. The most frequent departure time is 5:00PM, with 50% of daily flights leaving in the afternoon.

How many flights depart from Chicago O'Hare Intl Airport to South Carolina on average per week?

As of December 2025, 644 flights take off from Chicago O'Hare Intl Airport and land in South Carolina each week. The most common flight departure day for this route is Thu, with 16% of weekly flights taking off on this day.

Cheap Chicago O'Hare Intl Airport to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to South Carolina

Best Price Found

Fastest flight time

Direct flights

Airports in South Carolina

When did momondo last update prices for flights from Chicago O'Hare Intl Airport to South Carolina?

How many operators does momondo search for flights from Chicago O'Hare Intl Airport to South Carolina?

How old do you have to be to fly from Chicago O'Hare Intl Airport to South Carolina?

What documentation or ID do you need to fly to South Carolina?

What is the most popular plane model from Chicago O'Hare Intl Airport to South Carolina?

Best airlines flying from Chicago O'Hare Intl Airport to South Carolina

Compare and see reviews for airlines that fly from Chicago O'Hare Intl Airport to South Carolina with momondo

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to South Carolina?

Can I find flights from Chicago to South Carolina with flexible booking policies on momondo?

How can momondo help me find flights from Chicago to South Carolina?

I’m not ready to book a flight from Chicago to South Carolina right now. Can momondo alert me if prices change?

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to South Carolina

Popular cities in South Carolina

Popular flights according to clicks in the last 7 days on momondo