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Cheap flights from Chicago O'Hare Intl Airport to South Carolina from $84

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago O'Hare Intl Airport to South Carolina departing on 9/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Chicago O'Hare Intl Airport to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:11 am - 5:14 pmORD  Chicago O'Hare Intl-GSP Greenville
9h 03m1 stop Fort Lauderdale
Multiple Airlines Logo
2:18 pm - 3:20 pmGSP  Greenville-ORD Chicago O'Hare Intl
26h 02m1 stop Fort Lauderdale
$178Multiple Airlines
Tue, Sep 15 - Fri, Sep 18
Multiple Airlines Logo
7:11 am - 6:30 pmORD  Chicago O'Hare Intl-GSP Greenville
10h 19m1 stop Fort Lauderdale
Multiple Airlines Logo
7:03 pm - 3:20 pmGSP  Greenville-ORD Chicago O'Hare Intl
21h 17m2 stops Tampa Fort Lauderdale
$187Multiple Airlines
Fri, Sep 18 - Mon, Sep 21
United Airlines Logo
6:10 pm - 9:34 pmORD  Chicago O'Hare Intl-CHS Charleston
2h 24mnonstop
United Airlines Logo
6:30 am - 8:00 amCHS  Charleston-ORD Chicago O'Hare Intl
2h 30mnonstop
$237United Airlines
Sat, Sep 5 - Sun, Sep 6
American Airlines Logo
8:37 pm - 11:59 pmORD  Chicago O'Hare Intl-CHS Charleston
2h 22mnonstop
American Airlines Logo
12:23 pm - 1:59 pmCHS  Charleston-ORD Chicago O'Hare Intl
2h 36mnonstop
$239American Airlines
Sat, Sep 5 - Sun, Sep 6
United Airlines Logo
7:25 am - 10:27 amORD  Chicago O'Hare Intl-CHS Charleston
2h 02mnonstop
United Airlines Logo
2:30 pm - 6:33 pmCHS  Charleston-ORD Chicago O'Hare Intl
5h 03m1 stop Washington, D.C. Dulles Intl
$240United Airlines
Thu, Feb 4 - Sat, Feb 6
American Airlines Logo
9:53 am - 1:16 pmORD  Chicago O'Hare Intl-CHS Charleston
2h 23mnonstop
American Airlines Logo
12:22 pm - 5:38 pmCHS  Charleston-ORD Chicago O'Hare Intl
6h 16m1 stop Charlotte Douglas
$240American Airlines
Wed, Sep 16 - Mon, Sep 21
Frontier Logo
6:00 am - 1:28 pmORD  Chicago O'Hare Intl-CLT Charlotte Douglas
6h 28m1 stop Baltimore/Washington
Frontier Logo
9:32 am - 6:31 pmCLT  Charlotte Douglas-ORD Chicago O'Hare Intl
9h 59m2 stops Orlando Atlanta Hartsfield-Jackson
$242Frontier
Thu, Oct 15 - Wed, Oct 21
Frontier Logo
6:00 am - 1:28 pmORD  Chicago O'Hare Intl-CLT Charlotte Douglas
6h 28m1 stop Baltimore/Washington
Frontier Logo
8:11 pm - 5:35 amCLT  Charlotte Douglas-ORD Chicago O'Hare Intl
34h 24m2 stops Orlando Las Vegas Harry Reid Intl
$243Frontier
Fri, Oct 23 - Tue, Oct 27
Delta Logo
9:54 am - 4:12 pmORD  Chicago O'Hare Intl-CLT Charlotte Douglas
5h 18m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:00 pm - 8:30 pmCLT  Charlotte Douglas-ORD Chicago O'Hare Intl
4h 30m1 stop Detroit Metropolitan Wayne County
$249Delta
Fri, Sep 4 - Tue, Sep 8
Delta Logo
3:40 pm - 9:41 pmORD  Chicago O'Hare Intl-MYR Myrtle Beach Intl
5h 01m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:56 pm - 11:59 pmMYR  Myrtle Beach Intl-ORD Chicago O'Hare Intl
6h 03m1 stop Atlanta Hartsfield-Jackson
$283Delta
Fri, Sep 11 - Fri, Sep 18

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Frontier flights from Chicago O'Hare Intl Airport to South Carolina

Our best Frontier deals on Chicago O'Hare Intl Airport to South Carolina flight tickets
Frontier
Oct 15
ORD6:00 amChicago O'Hare Intl
6h 28m
1 stop
CLT1:28 pmCharlotte Douglas
Oct 21
CLT9:32 amCharlotte Douglas
9h 59m
2 stops
ORD6:31 pmChicago O'Hare Intl
$242
Frontier
Sep 8
ORD5:29 pmChicago O'Hare Intl
17h 08m
1 stop
CLT11:37 amCharlotte Douglas
Sep 14
CLT12:09 pmCharlotte Douglas
27h 08m
1 stop
ORD2:17 pmChicago O'Hare Intl
$254
Frontier
Sep 27
ORD6:20 amChicago O'Hare Intl
6h 48m
1 stop
CLT2:08 pmCharlotte Douglas
Oct 4
CLT12:09 pmCharlotte Douglas
10h 30m
1 stop
ORD9:39 pmChicago O'Hare Intl
$255

United Airlines flights from Chicago O'Hare Intl Airport to South Carolina

Our best United Airlines deals on Chicago O'Hare Intl Airport to South Carolina flight tickets
United Airlines
Sep 16
ORD4:20 pmChicago O'Hare Intl
2h 20m
CHS7:40 pmCharleston
Sep 21
CHS7:51 pmCharleston
4h 49m
1 stop
ORD11:40 pmChicago O'Hare Intl
$240
United Airlines
Sep 3
ORD6:10 pmChicago O'Hare Intl
2h 24m
CHS9:34 pmCharleston
Sep 6
CHS11:40 amCharleston
2h 33m
ORD1:13 pmChicago O'Hare Intl
$244
United Airlines
Sep 3
ORD6:50 amChicago O'Hare Intl
2h 18m
CLT10:08 amCharlotte Douglas
Sep 6
CLT6:00 amCharlotte Douglas
6h 53m
1 stop
ORD11:53 amChicago O'Hare Intl
$246

momondo Fare Finder

 
Customize your flight search to find flights from Chicago O'Hare Intl Airport to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Tue 9/15

7:11 am-5:14 pm

1 stop9h 03m

Greenville

Fri 9/18

2:18 pm-3:20 pm

1 stop26h 02m

$178

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Fri 9/18

7:11 am-6:30 pm

1 stop10h 19m

Greenville

Mon 9/21

7:03 pm-3:20 pm

2 stops21h 17m

$187
Quickest round-trip

ChicagoCharleston

ORD Chicago O'Hare Intl - CHS Charleston

ORDCHS

Chicago O'Hare Intl

Sat 9/5

6:10 pm-9:34 pm

Nonstop2h 24m

Charleston

Sun 9/6

6:30 am-8:00 am

Nonstop2h 30m

$237

ChicagoCharleston

ORD Chicago O'Hare Intl - CHS Charleston

ORDCHS

Chicago O'Hare Intl

Sat 9/5

8:37 pm-11:59 pm

Nonstop2h 22m

Charleston

Sun 9/6

12:23 pm-1:59 pm

Nonstop2h 36m

$239

ChicagoCharleston

ORD Chicago O'Hare Intl - CHS Charleston

ORDCHS

Chicago O'Hare Intl

Thu 2/4

7:25 am-10:27 am

Nonstop2h 02m

Charleston

Sat 2/6

2:30 pm-6:33 pm

1 stop5h 03m

$240

ChicagoCharleston

ORD Chicago O'Hare Intl - CHS Charleston

ORDCHS

Chicago O'Hare Intl

Wed 9/16

9:53 am-1:16 pm

Nonstop2h 23m

Charleston

Mon 9/21

12:22 pm-5:38 pm

1 stop6h 16m

$240

ChicagoCharlotte

ORD Chicago O'Hare Intl - CLT Charlotte Douglas

ORDCLT

Chicago O'Hare Intl

Thu 10/15

6:00 am-1:28 pm

1 stop6h 28m

Charlotte Douglas

Wed 10/21

9:32 am-6:31 pm

2 stops9h 59m

$242

ChicagoCharlotte

ORD Chicago O'Hare Intl - CLT Charlotte Douglas

ORDCLT

Chicago O'Hare Intl

Fri 10/23

6:00 am-1:28 pm

1 stop6h 28m

Charlotte Douglas

Tue 10/27

8:11 pm-5:35 am

2 stops34h 24m

$243

ChicagoCharlotte

ORD Chicago O'Hare Intl - CLT Charlotte Douglas

ORDCLT

Chicago O'Hare Intl

Fri 9/4

9:54 am-4:12 pm

1 stop5h 18m

Charlotte Douglas

Tue 9/8

5:00 pm-8:30 pm

1 stop4h 30m

$249

ChicagoMyrtle Beach

ORD Chicago O'Hare Intl - MYR Myrtle Beach Intl

ORDMYR

Chicago O'Hare Intl

Fri 9/11

3:40 pm-9:41 pm

1 stop5h 01m

Myrtle Beach Intl

Fri 9/18

6:56 pm-11:59 pm

1 stop6h 03m

$283

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Chicago O'Hare Intl Airport is in September. Flight prices, which tend to average around $335, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Chicago O'Hare Intl Airport during November instead. Flights to South Carolina in November, while not as cheap as those in September, still average around $354.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Tuesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $353. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $406.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Chicago O'Hare Intl Airport to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $372. Try not to purchase tickets in the afternoon because they tend to be around $388. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Chicago O'Hare Intl to South Carolina flight route?

Fly from Chicago O'Hare Intl to Charleston for the best Chicago O'Hare Intl - South Carolina flight prices

How far in advance should I book a flight from Chicago O'Hare Intl Airport to South Carolina?

You are more likely to see cheaper flights to South Carolina from Chicago O'Hare Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $387 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Chicago O'Hare Intl Airport for as low as $350 on momondo.

What cabin class options are available on Chicago O'Hare Intl Airport to South Carolina flights?

There are 4 cabin classes available to choose from on Chicago O'Hare Intl Airport to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago O'Hare Intl Airport to South Carolina flights?

You could potentially save up to 17% on your flight if you consider stops on a Chicago O'Hare Intl Airport to South Carolina flight.

Cheap Chicago O'Hare Intl Airport to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to South Carolina

Best Price Found

$189

Fastest flight time

1h 56m

Direct flights

Every day

Airports in South Carolina

57 airports
The best one-way flight to South Carolina from Chicago O'Hare Intl Airport in the past 72 hours is $189. The best round-trip flight deal from Chicago O'Hare Intl Airport to South Carolina found on momondo in the last 72 hours is $277.
The fastest flight from Chicago O'Hare Intl Airport to South Carolina takes 1h 56m
Direct flights go from Chicago O'Hare Intl Airport to South Carolina every day.
There are 57 airports in South Carolina. From Chicago O'Hare Intl Airport there are direct flights to Greenville (GSP), Columbia Metropolitan (CAE), Charlotte Douglas (CLT).
Search flight deals

Frequently asked questions about flying from Chicago O'Hare Intl Airport to South Carolina

  • When did momondo last update prices for flights from Chicago O'Hare Intl Airport to South Carolina?

    Prices for flights from Chicago O'Hare Intl Airport to South Carolina were last updated today.

  • How many operators does momondo search for flights from Chicago O'Hare Intl Airport to South Carolina?

  • How old do you have to be to fly from Chicago O'Hare Intl Airport to South Carolina?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Chicago O'Hare Intl Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents you'll need for your trip to South Carolina may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South Carolina. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Chicago O'Hare Intl Airport to South Carolina?

Best airlines flying from Chicago O'Hare Intl Airport to South Carolina

Compare and see reviews for airlines that fly from Chicago O'Hare Intl Airport to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $166Free CancellationRating
7.8
8,502 reviews
Search Delta flights
American AirlinesPriceFrom $202Free CancellationRating
7.1
11,923 reviews
Search American Airlines flights
United AirlinesPriceFrom $209Free CancellationRating
7.4
10,114 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Chicago to South Carolina for you.

Can I find flights from Chicago to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Chicago to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Chicago to South Carolina?

momondo helps you find the best flight between Chicago and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Chicago to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Chicago to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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