What is the cheapest airline that flies from Chicago O'Hare Intl to South Carolina?

Frontier, Spirit Airlines, and JetBlue are the most popular carriers operating from Chicago O'Hare Intl to South Carolina

How many flights depart from Chicago O'Hare Intl Airport to South Carolina on average per day?

The number of flights available between Chicago O'Hare Intl Airport and South Carolina is 79 per day as of January 2026. The most frequent departure time is 5:00PM, with 40% of daily flights leaving in the afternoon.

What airlines fly to South Carolina?

American Airlines, United Airlines and Spirit Airlines are the top three most popular airlines that fly to South Carolina from Chicago O'Hare Intl Airport according to our data. American Airlines is the first choice among our users, with 48% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 5 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

How many operators does momondo search for flights from Chicago O'Hare Intl Airport to South Carolina?

There are 6 operators available for flights from Chicago O'Hare Intl Airport to South Carolina as of January 2026.

How old do you have to be to fly from Chicago O'Hare Intl Airport to South Carolina?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Chicago O'Hare Intl Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents you'll need for your trip to South Carolina may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South Carolina. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$48 Cheap Flights from Chicago O'Hare Intl Airport to South Carolina in 2026

Q: How many flights depart from Chicago O'Hare Intl Airport to South Carolina on average per week?

As of January 2026, 557 flights take off from Chicago O'Hare Intl Airport and land in South Carolina each week. The most common flight departure day for this route is Thu, with 17% of weekly flights taking off on this day.

1 adult

0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Find the cheapest flights from Chicago O'Hare Intl Airport to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

11:50 am - 2:52 pm

ORD

CLT

2h 02mnonstop

9:21 pm - 10:52 pm

CLT

ORD

2h 31mnonstop

$86Frontier

Sun, Feb 15 - Fri, Feb 20

6:55 pm - 9:57 pm

ORD

CLT

2h 02mnonstop

10:58 pm - 12:29 am

CLT

ORD

2h 31mnonstop

$87Frontier

Fri, Mar 6 - Mon, Mar 9

6:51 pm - 2:55 pm

ORD

MYR

19h 04m

1 stop

11:57 am - 12:40 am

MYR

ORD

13h 43m

1 stop

$140Spirit Airlines

Tue, Feb 24 - Sat, Feb 28

6:51 pm - 11:02 am

ORD

MYR

15h 11m

1 stop

9:54 pm - 9:22 am

MYR

ORD

12h 28m

1 stop

$147Spirit Airlines

Fri, Feb 27 - Wed, Mar 4

7:05 am - 10:01 am

ORD

GSP

1h 56mnonstop

6:30 am - 7:53 am

GSP

ORD

2h 23mnonstop

$209United Airlines

Wed, Feb 25 - Wed, Mar 4

9:50 am - 5:15 pm

ORD

AGS

6h 25m

1 stop

7:36 pm - 11:54 pm

AGS

ORD

5h 18m

1 stop

$215Delta

Sat, Mar 14 - Fri, Mar 20

7:05 am - 10:01 am

ORD

GSP

1h 56mnonstop

10:00 am - 2:38 pm

GSP

ORD

5h 38m

1 stop

$219United Airlines

Wed, Feb 18 - Sat, Feb 21

8:55 pm - 11:58 pm

ORD

GSP

2h 03mnonstop

8:19 pm - 9:39 pm

GSP

ORD

2h 20mnonstop

$224American Airlines

Fri, May 1 - Mon, May 4

11:18 am - 6:05 pm

ORD

CAE

5h 47m

1 stop

6:50 pm - 11:56 pm

CAE

ORD

6h 06m

1 stop

$229Delta

Fri, Feb 20 - Sun, Feb 22

8:26 am - 3:36 pm

ORD

GSP

6h 10m

1 stop

11:29 am - 12:41 pm

GSP

ORD

2h 12mnonstop

$234American Airlines

Wed, Feb 25 - Tue, Mar 3

Frontier flights from Chicago O'Hare Intl Airport to South Carolina

Our best Frontier deals on Chicago O'Hare Intl Airport to South Carolina flight tickets

Frontier

Feb 15

ORD11:50 amChicago O'Hare Intl

2h 02m

CLT2:52 pmCharlotte Douglas

Feb 20

CLT9:21 pmCharlotte Douglas

2h 31m

ORD10:52 pmChicago O'Hare Intl

$86

Frontier

Mar 6

ORD6:55 pmChicago O'Hare Intl

2h 02m

CLT9:57 pmCharlotte Douglas

Mar 9

CLT10:58 pmCharlotte Douglas

2h 31m

ORD12:29 amChicago O'Hare Intl

$87

Frontier

Mar 6

ORD6:55 pmChicago O'Hare Intl

2h 02m

CLT9:57 pmCharlotte Douglas

Mar 9

CLT10:58 pmCharlotte Douglas

2h 31m

ORD12:29 amChicago O'Hare Intl

$91

Spirit Airlines flights from Chicago O'Hare Intl Airport to South Carolina

Our best Spirit Airlines deals on Chicago O'Hare Intl Airport to South Carolina flight tickets

Spirit Airlines

Feb 28

ORD8:16 pmChicago O'Hare Intl

11h 10m

1 stop

CLT8:26 amCharlotte Douglas

Mar 4

CLT1:24 pmCharlotte Douglas

6h 47m

1 stop

ORD7:11 pmChicago O'Hare Intl

$125

Spirit Airlines

Feb 18

ORD4:43 pmChicago O'Hare Intl

6h 13m

1 stop

CLT11:56 pmCharlotte Douglas

Feb 19

CLT1:24 pmCharlotte Douglas

11h 23m

1 stop

ORD11:47 pmChicago O'Hare Intl

$136

Spirit Airlines

Feb 24

ORD6:51 pmChicago O'Hare Intl

19h 04m

1 stop

MYR2:55 pmMyrtle Beach Intl

Feb 28

MYR11:57 amMyrtle Beach Intl

13h 43m

1 stop

ORD12:40 amChicago O'Hare Intl

$140

momondo Fare Finder

Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Sun 2/15

11:50 am-2:52 pm

Nonstop2h 02m

Charlotte Douglas

Fri 2/20

9:21 pm-10:52 pm

Nonstop2h 31m

$86

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Fri 3/6

6:55 pm-9:57 pm

Nonstop2h 02m

Charlotte Douglas

Mon 3/9

10:58 pm-12:29 am

Nonstop2h 31m

$87

ChicagoMyrtle Beach

ORD - MYR

ORDMYR

Chicago O'Hare Intl

Tue 2/24

6:51 pm-2:55 pm

1 stop19h 04m

Myrtle Beach Intl

Sat 2/28

11:57 am-12:40 am

1 stop13h 43m

$140

ChicagoMyrtle Beach

ORD - MYR

ORDMYR

Chicago O'Hare Intl

Fri 2/27

6:51 pm-11:02 am

1 stop15h 11m

Myrtle Beach Intl

Wed 3/4

9:54 pm-9:22 am

1 stop12h 28m

$147

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Wed 2/25

7:05 am-10:01 am

Nonstop1h 56m

Greenville

Wed 3/4

6:30 am-7:53 am

Nonstop2h 23m

$209

ChicagoAugusta

ORD - AGS

ORDAGS

Chicago O'Hare Intl

Sat 3/14

9:50 am-5:15 pm

1 stop6h 25m

Augusta Bush Field

Fri 3/20

7:36 pm-11:54 pm

1 stop5h 18m

$215

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Wed 2/18

7:05 am-10:01 am

Nonstop1h 56m

Greenville

Sat 2/21

10:00 am-2:38 pm

1 stop5h 38m

$219

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Fri 5/1

8:55 pm-11:58 pm

Nonstop2h 03m

Greenville

Mon 5/4

8:19 pm-9:39 pm

Nonstop2h 20m

$224

ChicagoColumbia

ORD - CAE

ORDCAE

Chicago O'Hare Intl

Fri 2/20

11:18 am-6:05 pm

1 stop5h 47m

Columbia Metropolitan

Sun 2/22

6:50 pm-11:56 pm

1 stop6h 06m

$229

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Wed 2/25

8:26 am-3:36 pm

1 stop6h 10m

Greenville

Tue 3/3

11:29 am-12:41 pm

Nonstop2h 12m

$234

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Chicago O'Hare Intl Airport is in August. Flight prices, which tend to average around $326, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of August, then book flights to South Carolina from Chicago O'Hare Intl Airport during September instead. Flights to South Carolina in September, while not as cheap as those in August, still average around $327.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $354. The most expensive day to fly to South Carolina is Friday, with ticket prices averaging around $395.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Chicago O'Hare Intl Airport to South Carolina flights are usually those with departure times at noon. Our users have found flights to South Carolina at noon for as low as $366. Try not to purchase tickets in the morning because they tend to be around $383. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Chicago O'Hare Intl to South Carolina flight route?

Fly from Chicago O'Hare Intl to Charleston for the best Chicago O'Hare Intl - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Chicago O'Hare Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $377 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Chicago O'Hare Intl Airport for as low as $322 on momondo.

What cabin class options are available on Chicago O'Hare Intl to South Carolina flights?

There are 4 cabin classes available to choose from on Chicago O'Hare Intl to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago O'Hare Intl Airport to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Chicago O'Hare Intl Airport to South Carolina.

Cheap Chicago O'Hare Intl Airport to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to South Carolina

Best Price Found	$144
Fastest flight time	1h 56m
Direct flights	Every day
Airports in South Carolina	57 airports

The best one-way flight to South Carolina from Chicago O'Hare Intl Airport in the past 72 hours is $144. The best round-trip flight deal from Chicago O'Hare Intl Airport to South Carolina found on momondo in the last 72 hours is $209.

The fastest flight from Chicago O'Hare Intl Airport to South Carolina takes 1h 56m

Direct flights go from Chicago O'Hare Intl Airport to South Carolina every day.

There are 57 airports in South Carolina. From Chicago O'Hare Intl Airport there are direct flights to Greenville (GSP), Columbia Metropolitan (CAE), Charlotte Douglas (CLT), Charleston (CHS).

Search flight deals

When did momondo last update prices for flights from Chicago O'Hare Intl Airport to South Carolina?
Prices for flights from Chicago O'Hare Intl Airport to South Carolina were last updated today.
How many operators does momondo search for flights from Chicago O'Hare Intl Airport to South Carolina?
There are 6 operators available for flights from Chicago O'Hare Intl Airport to South Carolina as of January 2026.
How old do you have to be to fly from Chicago O'Hare Intl Airport to South Carolina?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Chicago O'Hare Intl Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents you'll need for your trip to South Carolina may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South Carolina. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular plane model from Chicago O'Hare Intl Airport to South Carolina?
momondo data reveals that the most frequently booked plane model on the route from Chicago O'Hare Intl Airport to South Carolina is Embraer 175 (Enhanced Winglets), representing 23.53% of all bookings. The subsequent popular models are Embraer 175 at 19.21%, Airbus A319 at 13.31%, and Embraer 170 at 9.56%.

Best airlines flying from Chicago O'Hare Intl Airport to South Carolina

Compare and see reviews for airlines that fly from Chicago O'Hare Intl Airport to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Spirit Airlines	PriceFrom $51	Free Cancellation	Rating 6.3 8,393 reviews	Search Spirit Airlines flights
Delta	PriceFrom $148	Free Cancellation	Rating 7.9 8,128 reviews	Search Delta flights
United Airlines	PriceFrom $153	Free Cancellation	Rating 7.4 9,215 reviews	Search United Airlines flights
American Airlines	PriceFrom $197	Free Cancellation	Rating 7.2 11,205 reviews	Search American Airlines flights
Southwest	PriceFrom $210	Free Cancellation	Rating 8.0 4,267 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Chicago to South Carolina for you.

Can I find flights from Chicago to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Chicago to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Chicago to South Carolina?

momondo helps you find the best flight between Chicago and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Chicago to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Chicago to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Start using Trips

Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

1 adult

Sat 2/28

Sat 3/7

Email me momondo's favorite deals

By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to South Carolina

Popular cities in South Carolina

Flights to New Yorkfrom $38

Flights to Los Angelesfrom $31

Flights to Miamifrom $49

Flights to Chicagofrom $49

Flights to Orlandofrom $44

Flights to San Franciscofrom $73

Flights to Las Vegasfrom $53

Flights to Washington, D.C.from $49

Flights to Bostonfrom $52

Flights to Atlantafrom $44

Flights to Dallasfrom $54

Flights to Seattlefrom $56

Chicago O'Hare Intl Airport flight routes

Flights from Chicago O'Hare Intl to New York John F Kennedy Intl

Flights from Chicago O'Hare Intl to Baltimore/Washington

Flights from Chicago O'Hare Intl to Fort Myers SW Florida Intl

Flights from Chicago O'Hare Intl to Fort Lauderdale

Flights from Chicago O'Hare Intl to Miami

Flights from Chicago O'Hare Intl to Austin Bergstrom

Cheap flights from Chicago O'Hare Intl Airport to South Carolina from $48

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

Trusted and free

Price Alerts

Price Alerts

Find the cheapest flights from Chicago O'Hare Intl Airport to South Carolina

Cheap round-trip flights

Cheap one-way flights

Cheap last minute flights

Cheap direct flights

Frontier flights from Chicago O'Hare Intl Airport to South Carolina

Our best Frontier deals on Chicago O'Hare Intl Airport to South Carolina flight tickets

Spirit Airlines flights from Chicago O'Hare Intl Airport to South Carolina

Our best Spirit Airlines deals on Chicago O'Hare Intl Airport to South Carolina flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to South Carolina that are best for you.

See travel insights to South Carolina from

How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to South Carolina

What is the cheapest month to fly to South Carolina?

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $354. The most expensive day to fly to South Carolina is Friday, with ticket prices averaging around $395.

What is the cheapest time of day to depart on your flight to South Carolina?

What is the cheapest Chicago O'Hare Intl to South Carolina flight route?

Fly from Chicago O'Hare Intl to Charleston for the best Chicago O'Hare Intl - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

What cabin class options are available on Chicago O'Hare Intl to South Carolina flights?

There are 4 cabin classes available to choose from on Chicago O'Hare Intl to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago O'Hare Intl Airport to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Chicago O'Hare Intl Airport to South Carolina.

What is the cheapest airline that flies from Chicago O'Hare Intl to South Carolina?

Frontier, Spirit Airlines, and JetBlue are the most popular carriers operating from Chicago O'Hare Intl to South Carolina

What airlines fly to South Carolina?

How many flights depart from Chicago O'Hare Intl Airport to South Carolina on average per day?

The number of flights available between Chicago O'Hare Intl Airport and South Carolina is 79 per day as of January 2026. The most frequent departure time is 5:00PM, with 40% of daily flights leaving in the afternoon.

How many flights depart from Chicago O'Hare Intl Airport to South Carolina on average per week?

As of January 2026, 557 flights take off from Chicago O'Hare Intl Airport and land in South Carolina each week. The most common flight departure day for this route is Thu, with 17% of weekly flights taking off on this day.

Cheap Chicago O'Hare Intl Airport to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to South Carolina

Best Price Found

Fastest flight time

Direct flights

Airports in South Carolina

When did momondo last update prices for flights from Chicago O'Hare Intl Airport to South Carolina?

How many operators does momondo search for flights from Chicago O'Hare Intl Airport to South Carolina?

How old do you have to be to fly from Chicago O'Hare Intl Airport to South Carolina?

What documentation or ID do you need to fly to South Carolina?

What is the most popular plane model from Chicago O'Hare Intl Airport to South Carolina?

Best airlines flying from Chicago O'Hare Intl Airport to South Carolina

Compare and see reviews for airlines that fly from Chicago O'Hare Intl Airport to South Carolina with momondo

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to South Carolina?

Can I find flights from Chicago to South Carolina with flexible booking policies on momondo?

How can momondo help me find flights from Chicago to South Carolina?

I’m not ready to book a flight from Chicago to South Carolina right now. Can momondo alert me if prices change?

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to South Carolina

Popular cities in South Carolina

Popular flights according to clicks in the last 7 days on momondo