Cheap flights from Chicago O'Hare Intl Airport to South Carolina from $99
This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago O'Hare Intl Airport to South Carolina departing on 11/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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American Airlines flights from Chicago O'Hare Intl Airport to South Carolina
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Fly from
Fly to
Route
Depart
Return
ChicagoMyrtle Beach
ORD Chicago O'Hare Intl - MYR Myrtle Beach Intl
ORDMYR
Chicago O'Hare Intl
Thu 10/29
8:00 am-8:03 am
1 stop23h 03m
Myrtle Beach Intl
Thu 11/5
8:15 pm-3:37 pm
1 stop20h 22m
ChicagoMyrtle Beach
ORD Chicago O'Hare Intl - MYR Myrtle Beach Intl
ORDMYR
Chicago O'Hare Intl
Fri 10/30
7:50 pm-9:51 am
2 stops37h 01m
Myrtle Beach Intl
Thu 11/5
8:15 pm-3:37 pm
1 stop20h 22m
ChicagoMyrtle Beach
ORD Chicago O'Hare Intl - MYR Myrtle Beach Intl
ORDMYR
Chicago O'Hare Intl
Sat 2/13
10:00 am-1:16 pm
Nonstop2h 16m
Myrtle Beach Intl
Tue 2/16
7:58 pm-9:45 pm
Nonstop2h 47m
ChicagoCharleston
ORD Chicago O'Hare Intl - CHS Charleston
ORDCHS
Chicago O'Hare Intl
Sat 12/5
12:55 pm-7:58 pm
1 stop6h 03m
Charleston
Mon 12/7
12:17 pm-1:59 pm
Nonstop2h 42m
ChicagoMyrtle Beach
ORD Chicago O'Hare Intl - MYR Myrtle Beach Intl
ORDMYR
Chicago O'Hare Intl
Sat 10/31
7:20 pm-3:33 pm
2 stops19h 13m
Myrtle Beach Intl
Thu 11/5
8:15 pm-3:37 pm
1 stop20h 22m
ChicagoCharleston
ORD Chicago O'Hare Intl - CHS Charleston
ORDCHS
Chicago O'Hare Intl
Sat 10/31
10:08 am-3:54 pm
1 stop4h 46m
Charleston
Mon 11/2
12:17 pm-1:59 pm
Nonstop2h 42m
ChicagoCharleston
ORD Chicago O'Hare Intl - CHS Charleston
ORDCHS
Chicago O'Hare Intl
Fri 2/5
6:23 pm-9:55 pm
Nonstop2h 32m
Charleston
Tue 2/9
9:50 am-11:29 am
Nonstop2h 39m
ChicagoCharleston
ORD Chicago O'Hare Intl - CHS Charleston
ORDCHS
Chicago O'Hare Intl
Wed 11/11
5:30 am-12:52 pm
1 stop6h 22m
Charleston
Sat 11/14
12:58 pm-5:05 pm
1 stop5h 07m
ChicagoCharleston
ORD Chicago O'Hare Intl - CHS Charleston
ORDCHS
Chicago O'Hare Intl
Sat 11/7
1:55 pm-10:05 pm
1 stop7h 10m
Charleston
Sat 11/14
8:30 am-12:20 pm
1 stop4h 50m
ChicagoCharleston
ORD Chicago O'Hare Intl - CHS Charleston
ORDCHS
Chicago O'Hare Intl
Fri 2/5
10:25 am-1:46 pm
Nonstop2h 21m
Charleston
Tue 2/9
2:42 pm-6:40 pm
1 stop4h 58m
See travel insights to South Carolina from
How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to South Carolina
Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip
What is the cheapest month to fly to South Carolina?
The cheapest month to fly to South Carolina from Chicago O'Hare Intl Airport is in September. Flight prices, which tend to average around $362, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Chicago O'Hare Intl Airport during November instead. Flights to South Carolina in November, while not as cheap as those in September, still average around $364.
What is the cheapest day to depart on your flight to South Carolina?
Our data shows that Tuesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $352. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $409.
What is the cheapest time of day to depart on your flight to South Carolina?
Our data shows that the cheapest Chicago O'Hare Intl Airport to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $386. Try not to purchase tickets at noon because they tend to be around $391. Of course, these prices can vary depending on the time of year and what airport you fly to.
What is the cheapest Chicago O'Hare Intl to South Carolina flight route?
Fly from Chicago O'Hare Intl to Columbia Metropolitan for the best Chicago O'Hare Intl - South Carolina flight prices
How far in advance should I book a flight from Chicago O'Hare Intl Airport to South Carolina?
You are more likely to see cheaper flights to South Carolina from Chicago O'Hare Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $388 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Chicago O'Hare Intl Airport for as low as $349 on momondo.
What cabin class options are available on Chicago O'Hare Intl Airport to South Carolina flights?
There are 4 cabin classes available to choose from on Chicago O'Hare Intl Airport to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.
What is the cheapest airline that flies from Chicago O'Hare Intl to South Carolina?
Delta, United Airlines, and American Airlines are the most popular carriers operating from Chicago O'Hare Intl to South Carolina
What airlines fly to South Carolina?
United Airlines, American Airlines and Delta are the top three most popular airlines that fly to South Carolina from Chicago O'Hare Intl Airport according to our data. United Airlines is the first choice among our users, with 51% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 3 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.
How many flights depart from Chicago O'Hare Intl Airport to South Carolina on average per day?
The number of flights available between Chicago O'Hare Intl Airport and South Carolina is 49 per day as of October 2026. The most frequent departure time is 6:00PM, with 45% of daily flights leaving at noon.
How many flights depart from Chicago O'Hare Intl Airport to South Carolina on average per week?
As of October 2026, 345 flights take off from Chicago O'Hare Intl Airport and land in South Carolina each week. The most common flight departure day for this route is Mon, with 16% of weekly flights taking off on this day.
Cheap Chicago O'Hare Intl Airport to South Carolina flight deals and tips
Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to South Carolina
Frequently asked questions about flying from Chicago O'Hare Intl Airport to South Carolina
When did momondo last update prices for flights from Chicago O'Hare Intl Airport to South Carolina?
Prices for flights from Chicago O'Hare Intl Airport to South Carolina were last updated today.
How many operators does momondo search for flights from Chicago O'Hare Intl Airport to South Carolina?
There are 3 operators available for flights from Chicago O'Hare Intl Airport to South Carolina as of October 2026.
How old do you have to be to fly from Chicago O'Hare Intl Airport to South Carolina?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Chicago O'Hare Intl Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents you'll need for your trip to South Carolina may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South Carolina. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular plane model from Chicago O'Hare Intl Airport to South Carolina?
momondo data reveals that the most frequently booked plane model on the route from Chicago O'Hare Intl Airport to South Carolina is Embraer 175 (Enhanced Winglets), representing 18.88% of all bookings. The subsequent popular models are Embraer 175 at 15.98%, Boeing 737-800 at 15.68%, and Airbus A319 at 13.17%.
Best airlines flying from Chicago O'Hare Intl Airport to South Carolina
Compare and see reviews for airlines that fly from Chicago O'Hare Intl Airport to South Carolina with momondo
| Airline | Rating | Free Cancellation | Price | ||
|---|---|---|---|---|---|
| PriceFrom $152 | Free Cancellation | Rating 7.8 8,633 reviews | |||
| PriceFrom $209 | Free Cancellation | Rating 7.0 12,129 reviews | |||
| PriceFrom $209 | Free Cancellation | Rating 7.4 10,301 reviews |
Why use momondo?
Why should I use momondo to find a flight deal from Chicago to South Carolina?
We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Chicago to South Carolina for you.
Can I find flights from Chicago to South Carolina with flexible booking policies on momondo?
Yes. momondo allows you to filter the results for Chicago to South Carolina flights to just show those with flexible booking policies.
How can momondo help me find flights from Chicago to South Carolina?
momondo helps you find the best flight between Chicago and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.
I’m not ready to book a flight from Chicago to South Carolina right now. Can momondo alert me if prices change?
Of course. momondo tracks the price of Chicago to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.