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Cheap flights from North Carolina to Des Moines from $109

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from North Carolina to Des Moines departing on 5/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from North Carolina to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
10:38 pm - 10:05 am
RDU
-
DSM
12h 27m
1 stop
Frontier Logo
8:21 pm - 5:48 pm
DSM
-
RDU
20h 27m
1 stop
$234Frontier
Mon, Mar 9 - Wed, Mar 11
Multiple Airlines Logo
8:55 am - 4:00 pm
CLT
-
DSM
8h 05m
1 stop
Multiple Airlines Logo
8:30 am - 2:18 pm
DSM
-
CLT
28h 48m
1 stop
$241Multiple Airlines
Thu, Apr 23 - Sun, Apr 26
Multiple Airlines Logo
7:13 pm - 11:12 pm
CLT
-
DSM
28h 59m
1 stop
Multiple Airlines Logo
8:38 pm - 8:26 am
DSM
-
CLT
34h 48m
2 stops
$251Multiple Airlines
Wed, Feb 18 - Mon, Feb 23
Delta Logo
12:22 pm - 7:34 pm
AVL
-
DSM
8h 12m
1 stop
Delta Logo
6:41 pm - 11:37 pm
DSM
-
AVL
3h 56m
1 stop
$269Delta
Thu, May 7 - Sun, May 10
United Airlines Logo
5:20 pm - 9:27 pm
RDU
-
DSM
5h 07m
1 stop
United Airlines Logo
6:20 am - 1:58 pm
DSM
-
RDU
6h 38m
1 stop
$271United Airlines
Tue, Apr 7 - Wed, Apr 15
Delta Logo
5:45 am - 1:59 pm
AVL
-
DSM
9h 14m
2 stops
Delta Logo
5:29 am - 10:35 am
DSM
-
AVL
4h 06m
1 stop
$274Delta
Thu, May 7 - Sun, May 10
Southwest Logo
1:25 pm - 10:10 pm
RDU
-
DSM
9h 45m
2 stops
Southwest Logo
3:15 pm - 8:55 pm
DSM
-
RDU
4h 40m
1 stop
$276Southwest
Tue, Apr 7 - Wed, Apr 15
United Airlines Logo
6:00 am - 12:29 pm
RDU
-
DSM
7h 29m
2 stops
United Airlines Logo
6:20 am - 2:06 pm
DSM
-
RDU
6h 46m
2 stops
$282United Airlines
Tue, Apr 7 - Wed, Apr 15
Delta Logo
6:13 am - 10:18 am
TYS
-
DSM
5h 05m
1 stop
Delta Logo
4:23 pm - 10:59 pm
DSM
-
TYS
5h 36m
1 stop
$293Delta
Thu, Apr 23 - Mon, Apr 27
Southwest Logo
6:10 am - 12:10 pm
RDU
-
DSM
7h 00m
2 stops
Southwest Logo
5:30 am - 1:05 pm
DSM
-
RDU
6h 35m
2 stops
$339Southwest
Mon, Apr 6 - Wed, Apr 8

Delta flights from North Carolina to Des Moines

Our best Delta deals on North Carolina to Des Moines flight tickets
Delta
May 7
AVL12:22 pmAsheville Regional
8h 12m
1 stop
DSM7:34 pmDes Moines
May 10
DSM6:41 pmDes Moines
3h 56m
1 stop
AVL11:37 pmAsheville Regional
$269
Delta
May 7
AVL5:45 amAsheville Regional
9h 14m
2 stops
DSM1:59 pmDes Moines
May 10
DSM5:29 amDes Moines
4h 06m
1 stop
AVL10:35 amAsheville Regional
$274
Delta
May 18
RDU6:00 amRaleigh-Durham
5h 16m
1 stop
DSM10:16 amDes Moines
May 20
DSM7:34 amDes Moines
6h 44m
1 stop
RDU3:18 pmRaleigh-Durham
$290

Allegiant Air flights from North Carolina to Des Moines

Our best Allegiant Air deals on North Carolina to Des Moines flight tickets
Allegiant Air
May 15
TYS8:30 amKnoxville McGhee Tyson
15h 27m
2 stops
DSM10:57 pmDes Moines
May 18
DSM2:03 pmDes Moines
23h 55m
1 stop
TYS2:58 pmKnoxville McGhee Tyson
$430
Allegiant Air
Mar 7
TYS9:34 pmKnoxville McGhee Tyson
25h 36m
1 stop
DSM10:10 pmDes Moines
Mar 15
DSM7:00 amDes Moines
28h 46m
1 stop
TYS12:46 pmKnoxville McGhee Tyson
$527

momondo Fare Finder

 
Customize your flight search to find flights from North Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 7, 2026.
Use the filters below to find and compare flights from North Carolina to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

Mon 3/9

10:38 pm-10:05 am

1 stop12h 27m

Des Moines

Wed 3/11

8:21 pm-5:48 pm

1 stop20h 27m

$234

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 4/23

8:55 am-4:00 pm

1 stop8h 05m

Des Moines

Sun 4/26

8:30 am-2:18 pm

1 stop28h 48m

$241

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 2/18

7:13 pm-11:12 pm

1 stop28h 59m

Des Moines

Mon 2/23

8:38 pm-8:26 am

2 stops34h 48m

$251

AshevilleDes Moines

AVL - DSM

AVLDSM

Asheville Regional

Thu 5/7

12:22 pm-7:34 pm

1 stop8h 12m

Des Moines

Sun 5/10

6:41 pm-11:37 pm

1 stop3h 56m

$269

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

Tue 4/7

5:20 pm-9:27 pm

1 stop5h 07m

Des Moines

Wed 4/15

6:20 am-1:58 pm

1 stop6h 38m

$271

AshevilleDes Moines

AVL - DSM

AVLDSM

Asheville Regional

Thu 5/7

5:45 am-1:59 pm

2 stops9h 14m

Des Moines

Sun 5/10

5:29 am-10:35 am

1 stop4h 06m

$274

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

Tue 4/7

1:25 pm-10:10 pm

2 stops9h 45m

Des Moines

Wed 4/15

3:15 pm-8:55 pm

1 stop4h 40m

$276

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

Tue 4/7

6:00 am-12:29 pm

2 stops7h 29m

Des Moines

Wed 4/15

6:20 am-2:06 pm

2 stops6h 46m

$282

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 4/23

6:13 am-10:18 am

1 stop5h 05m

Des Moines

Mon 4/27

4:23 pm-10:59 pm

1 stop5h 36m

$293

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

Mon 4/6

6:10 am-12:10 pm

2 stops7h 00m

Des Moines

Wed 4/8

5:30 am-1:05 pm

2 stops6h 35m

$339

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from North Carolina to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in December, then August is your next best option. Flight prices from North Carolina to Des Moines during August average around $349.

What is the cheapest North Carolina to Des Moines flight route?

Fly from Charlotte Douglas to Des Moines for the best North Carolina - Des Moines flight prices

How far in advance should I book a flight to Des Moines?

You are more likely to see cheaper flights to Des Moines from North Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Des Moines for around $409 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Des Moines from North Carolina for as low as $343 on momondo.

What cabin class options are available on North Carolina to Des Moines flights?

There are 2 cabin classes available to choose from on North Carolina to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on North Carolina to Des Moines flights?

You could potentially save up to 77% on your flight if you consider stops on a North Carolina to Des Moines flight.

Cheap North Carolina to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from North Carolina to Des Moines

Best Price Found

$376

Fastest flight time

2h 33m

Direct flights

Every day

Airports in Des Moines

1 airport
The best flight deal from North Carolina to Des Moines found on momondo in the last 72 hours is $376
The fastest flight from North Carolina to Des Moines takes 2h 33m
Direct flights go from North Carolina to Des Moines every day.
There is 1 airport in Des Moines. From North Carolina there are direct flights to Des Moines (DSM).
Search flight deals

  • When did momondo last update prices for flights from North Carolina to Des Moines Airport?

    Prices for flights from North Carolina to Des Moines Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from North Carolina to Des Moines Airport?

  • How old do you have to be to fly from North Carolina to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from North Carolina to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from North Carolina to Des Moines?

Best airlines flying from North Carolina to Des Moines

Compare and see reviews for airlines that fly from North Carolina to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $238Free CancellationRating
7.9
8,172 reviews
Search Delta flights
American AirlinesPriceFrom $242Free CancellationRating
7.2
11,249 reviews
Search American Airlines flights
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,254 reviews
Search United Airlines flights
SouthwestPriceFrom $292Free CancellationRating
8.0
4,280 reviews
Search Southwest flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Boone
Osceola
Norwalk
Oskaloosa
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from North Carolina to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from North Carolina to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from North Carolina to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from North Carolina which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from North Carolina to Des Moines?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Des Moines from North Carolina.

I’m not ready to book a flight from North Carolina to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from North Carolina and alert you when they change.

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