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Cheap flights from Missouri to Santa Fe from $224

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Santa Fe departing on 12/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Missouri to Santa Fe

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
9:32 am - 3:42 pmSTL-SAF
7h 10m1 stop
American Airlines Logo
10:08 am - 5:05 pmSAF-STL
5h 57m1 stop
$314American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
5:14 am - 3:02 pmSTL-SAF
10h 48m2 stops
American Airlines Logo
3:32 pm - 11:51 pmSAF-STL
7h 19m1 stop
$324American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
United Airlines Logo
5:54 am - 9:24 amMCI-SAF
4h 30m1 stop
United Airlines Logo
1:23 pm - 8:35 pmSAF-MCI
6h 12m1 stop
$329United Airlines
Find Deal
Sat, Feb 28 - Tue, Mar 3
American Airlines Logo
5:13 am - 9:28 amMCI-SAF
5h 15m1 stop
American Airlines Logo
5:10 pm - 10:54 pmSAF-MCI
4h 44m1 stop
$350American Airlines
Find Deal
Mon, Dec 8 - Sat, Dec 13
United Airlines Logo
1:50 pm - 5:08 pmMCI-SAF
4h 18m1 stop
United Airlines Logo
3:20 pm - 11:17 pmSAF-MCI
6h 57m1 stop
$359United Airlines
Find Deal
Fri, Feb 20 - Tue, Feb 24
American Airlines Logo
10:58 am - 6:03 pmMCI-SAF
8h 05m2 stops
American Airlines Logo
6:15 am - 1:09 pmSAF-MCI
5h 54m1 stop
$360American Airlines
Find Deal
Fri, Feb 20 - Tue, Feb 24
United Airlines Logo
9:05 am - 12:40 pmMCI-SAF
4h 35m1 stop
United Airlines Logo
7:00 am - 12:45 pmSAF-MCI
4h 45m1 stop
$374United Airlines
Find Deal
Wed, Nov 19 - Sun, Nov 23
American Airlines Logo
5:14 am - 3:02 pmSTL-SAF
10h 48m2 stops
American Airlines Logo
3:32 pm - 11:51 pmSAF-STL
7h 19m1 stop
$376American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
5:14 am - 3:02 pmSTL-SAF
10h 48m2 stops
American Airlines Logo
3:32 pm - 9:33 amSAF-STL
17h 01m2 stops
$439American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
7:00 am - 12:46 pmSTL-SAF
6h 46m1 stop
American Airlines Logo
3:25 pm - 11:56 pmSAF-STL
7h 31m1 stop
$442American Airlines
Find Deal
Sun, Dec 7 - Thu, Dec 11

American Airlines flights from Missouri to Santa Fe

Our best American Airlines deals on Missouri to Santa Fe flight tickets
American Airlines
Feb 21
STL9:32 amLambert-St Louis
7h 10m
1 stop
SAF3:42 pmSanta Fe
Feb 25
SAF10:08 amSanta Fe
5h 57m
1 stop
STL5:05 pmLambert-St Louis
$314
Find similar
American Airlines
Feb 21
STL5:14 amLambert-St Louis
10h 48m
2 stops
SAF3:02 pmSanta Fe
Feb 25
SAF3:32 pmSanta Fe
7h 19m
1 stop
STL11:51 pmLambert-St Louis
$324
Find similar
American Airlines
Dec 8
MCI5:13 amKansas City
5h 15m
1 stop
SAF9:28 amSanta Fe
Dec 13
SAF5:10 pmSanta Fe
4h 44m
1 stop
MCI10:54 pmKansas City
$350
Find similar

United Airlines flights from Missouri to Santa Fe

Our best United Airlines deals on Missouri to Santa Fe flight tickets
United Airlines
Feb 28
MCI5:54 amKansas City
4h 30m
1 stop
SAF9:24 amSanta Fe
Mar 3
SAF1:23 pmSanta Fe
6h 12m
1 stop
MCI8:35 pmKansas City
$329
Find similar
United Airlines
Feb 20
MCI1:50 pmKansas City
4h 18m
1 stop
SAF5:08 pmSanta Fe
Feb 24
SAF3:20 pmSanta Fe
6h 57m
1 stop
MCI11:17 pmKansas City
$359
Find similar
United Airlines
Nov 19
MCI9:05 amKansas City
4h 35m
1 stop
SAF12:40 pmSanta Fe
Nov 23
SAF7:00 amSanta Fe
4h 45m
1 stop
MCI12:45 pmKansas City
$374
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 10, 2025.
Use the filters below to find and compare flights from Missouri to Santa Fe that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

Sat 2/21

9:32 am-3:42 pm

1 stop7h 10m

Santa Fe

Wed 2/25

10:08 am-5:05 pm

1 stop5h 57m

$314

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

Sat 2/21

5:14 am-3:02 pm

2 stops10h 48m

Santa Fe

Wed 2/25

3:32 pm-11:51 pm

1 stop7h 19m

$324

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

Sat 2/28

5:54 am-9:24 am

1 stop4h 30m

Santa Fe

Tue 3/3

1:23 pm-8:35 pm

1 stop6h 12m

$329

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

Mon 12/8

5:13 am-9:28 am

1 stop5h 15m

Santa Fe

Sat 12/13

5:10 pm-10:54 pm

1 stop4h 44m

$350

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

Fri 2/20

1:50 pm-5:08 pm

1 stop4h 18m

Santa Fe

Tue 2/24

3:20 pm-11:17 pm

1 stop6h 57m

$359

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

Fri 2/20

10:58 am-6:03 pm

2 stops8h 05m

Santa Fe

Tue 2/24

6:15 am-1:09 pm

1 stop5h 54m

$360

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

Wed 11/19

9:05 am-12:40 pm

1 stop4h 35m

Santa Fe

Sun 11/23

7:00 am-12:45 pm

1 stop4h 45m

$374

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

Sat 2/21

5:14 am-3:02 pm

2 stops10h 48m

Santa Fe

Wed 2/25

3:32 pm-11:51 pm

1 stop7h 19m

$376

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

Sat 2/21

5:14 am-3:02 pm

2 stops10h 48m

Santa Fe

Wed 2/25

3:32 pm-9:33 am

2 stops17h 01m

$439

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

Sun 12/7

7:00 am-12:46 pm

1 stop6h 46m

Santa Fe

Thu 12/11

3:25 pm-11:56 pm

1 stop7h 31m

$442

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Santa Fe from

How to get the cheapest flight ticket from Missouri to Santa Fe

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Santa Fe?

The month of January is, on average, the cheapest month to fly to Santa Fe from Missouri, with most prices found around $279. If you’re not able to fly to Santa Fe in January, then November is your next best option. Flight prices from Missouri to Santa Fe during November average around $311.

What is the cheapest day to depart on your flight to Santa Fe?

According to our data, Saturday is the cheapest day to fly to Santa Fe from Missouri. The lowest ticket price found for a Saturday departure recently was $323. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. Be sure to avoid booking your departure on a Thursday as prices are generally higher than usual. According to our data, the average ticket price to Santa Fe on Thursday is $530.

What is the cheapest time of day to depart on your flight to Santa Fe?

The cheapest time of day to fly to Santa Fe is in the afternoon when flights can be purchased for as low as $332. Try not to purchase tickets at noon because they tend to be around $481. Of course, these prices can vary depending on the time of year and what airport you fly to.

Cheap Missouri to Santa Fe flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Santa Fe

Direct flights

None
There are no direct flights from Missouri to Santa Fe. There are no popular flight routes from Missouri to Santa Fe.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Santa Fe Airport?

    Prices for flights from Missouri to Santa Fe Airport refresh daily.

  • How many operators does momondo search for flights from Missouri to Santa Fe Airport?

  • How old do you have to be to fly from Missouri to Santa Fe Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Santa Fe Airport.

  • What documentation or ID do you need to fly to Santa Fe Airport?

    The travel and health documents required for your trip to Santa Fe Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santa Fe Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Missouri to Santa Fe

Compare and see reviews for airlines that fly from Missouri to Santa Fe with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $243Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights
United AirlinesPriceFrom $244Free CancellationRating
7.4
9,012 reviews
Search United Airlines flights

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa
Los Alamos

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Santa Fe?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Missouri to Santa Fe for you.

Can I find flights from Missouri to Santa Fe with flexible booking policies on momondo?

All flight searches from Missouri to Santa Fe on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Missouri to Santa Fe?

momondo provides multiple filters to help you find the best flight to Santa Fe from Missouri. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Missouri to Santa Fe right now. Can momondo alert me if prices change?

Price alerts on flights to Santa Fe from Missouri are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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