Latest deals
Insights
FAQs
Reviews
Price Alerts

Cheap flights from Missouri to Knoxville from $66

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Knoxville departing on 11/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Missouri to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
3:02 pm - 10:55 pmCOU-TYS
6h 53m1 stop
United Airlines Logo
8:26 am - 2:26 pmTYS-COU
7h 00m1 stop
$228United Airlines
Find Deal
Tue, Nov 11 - Sat, Nov 15
United Airlines Logo
8:00 am - 8:20 pmCOU-TYS
11h 20m2 stops
United Airlines Logo
10:50 am - 2:26 pmTYS-COU
4h 36m1 stop
$234United Airlines
Find Deal
Tue, Nov 11 - Sat, Nov 15
American Airlines Logo
9:16 am - 5:27 pmSGF-TYS
7h 11m1 stop
American Airlines Logo
5:24 am - 11:33 amTYS-SGF
7h 09m1 stop
$249American Airlines
Find Deal
Fri, Dec 12 - Sun, Dec 14
Delta Logo
6:00 am - 1:26 pmSTL-TYS
6h 26m1 stop
Delta Logo
12:30 pm - 4:55 pmTYS-STL
5h 25m1 stop
$249Delta
Find Deal
Wed, Feb 18 - Sat, Feb 21
Multiple Airlines Logo
2:47 pm - 8:33 amSTL-TYS
16h 46m1 stop
Multiple Airlines Logo
4:52 pm - 10:14 amTYS-STL
18h 22m1 stop
$254Multiple Airlines
Find Deal
Thu, Dec 11 - Sun, Dec 14
Multiple Airlines Logo
2:47 pm - 8:33 amSTL-TYS
16h 46m1 stop
Multiple Airlines Logo
4:52 pm - 10:14 amTYS-STL
18h 22m1 stop
$257Multiple Airlines
Find Deal
Thu, Dec 11 - Sun, Dec 14
American Airlines Logo
5:48 am - 11:31 amMCI-TYS
4h 43m1 stop
American Airlines Logo
7:54 am - 2:22 pmTYS-MCI
7h 28m1 stop
$267American Airlines
Find Deal
Sat, Jan 10 - Tue, Jan 13
Delta Logo
7:00 am - 1:44 pmMCI-TYS
5h 44m1 stop
Delta Logo
1:27 pm - 5:27 pmTYS-MCI
5h 00m1 stop
$277Delta
Find Deal
Thu, Nov 27 - Sat, Dec 13
Allegiant Air Logo
8:00 pm - 8:27 pmSGF-TYS
23h 27m1 stop
Allegiant Air Logo
12:38 pm - 7:10 pmTYS-SGF
7h 32m1 stop
$296Allegiant Air
Find Deal
Sun, Nov 9 - Thu, Nov 13
Allegiant Air Logo
5:59 pm - 6:12 pmSGF-TYS
23h 13m1 stop
Allegiant Air Logo
5:51 pm - 9:49 amTYS-SGF
16h 58m1 stop
$365Allegiant Air
Find Deal
Tue, Dec 16 - Fri, Dec 19

United Airlines flights from Missouri to Knoxville

Our best United Airlines deals on Missouri to Knoxville flight tickets
United Airlines
Nov 11
COU3:02 pmColumbia Regional
6h 53m
1 stop
TYS10:55 pmKnoxville McGhee Tyson
Nov 15
TYS8:26 amKnoxville McGhee Tyson
7h 00m
1 stop
COU2:26 pmColumbia Regional
$228
Find similar
United Airlines
Nov 11
COU8:00 amColumbia Regional
11h 20m
2 stops
TYS8:20 pmKnoxville McGhee Tyson
Nov 15
TYS10:50 amKnoxville McGhee Tyson
4h 36m
1 stop
COU2:26 pmColumbia Regional
$234
Find similar
United Airlines
Nov 11
COU3:02 pmColumbia Regional
7h 57m
2 stops
TYS11:59 pmKnoxville McGhee Tyson
Nov 15
TYS2:25 pmKnoxville McGhee Tyson
7h 54m
2 stops
COU9:19 pmColumbia Regional
$239
Find similar

American Airlines flights from Missouri to Knoxville

Our best American Airlines deals on Missouri to Knoxville flight tickets
American Airlines
Dec 12
SGF9:16 amSpringfield-Branson
7h 11m
1 stop
TYS5:27 pmKnoxville McGhee Tyson
Dec 14
TYS5:24 amKnoxville McGhee Tyson
7h 09m
1 stop
SGF11:33 amSpringfield-Branson
$249
Find similar
American Airlines
Jan 10
MCI5:48 amKansas City
4h 43m
1 stop
TYS11:31 amKnoxville McGhee Tyson
Jan 13
TYS7:54 amKnoxville McGhee Tyson
7h 28m
1 stop
MCI2:22 pmKansas City
$267
Find similar
American Airlines
Jan 10
MCI6:00 amKansas City
8h 20m
2 stops
TYS3:20 pmKnoxville McGhee Tyson
Jan 13
TYS7:54 amKnoxville McGhee Tyson
7h 28m
1 stop
MCI2:22 pmKansas City
$272
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 27, 2025.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Tue 11/11

3:02 pm-10:55 pm

1 stop6h 53m

Knoxville McGhee Tyson

Sat 11/15

8:26 am-2:26 pm

1 stop7h 00m

$228

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Tue 11/11

8:00 am-8:20 pm

2 stops11h 20m

Knoxville McGhee Tyson

Sat 11/15

10:50 am-2:26 pm

1 stop4h 36m

$234

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

Fri 12/12

9:16 am-5:27 pm

1 stop7h 11m

Knoxville McGhee Tyson

Sun 12/14

5:24 am-11:33 am

1 stop7h 09m

$249

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 2/18

6:00 am-1:26 pm

1 stop6h 26m

Knoxville McGhee Tyson

Sat 2/21

12:30 pm-4:55 pm

1 stop5h 25m

$249

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 12/11

2:47 pm-8:33 am

1 stop16h 46m

Knoxville McGhee Tyson

Sun 12/14

4:52 pm-10:14 am

1 stop18h 22m

$254

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 12/11

2:47 pm-8:33 am

1 stop16h 46m

Knoxville McGhee Tyson

Sun 12/14

4:52 pm-10:14 am

1 stop18h 22m

$257

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Sat 1/10

5:48 am-11:31 am

1 stop4h 43m

Knoxville McGhee Tyson

Tue 1/13

7:54 am-2:22 pm

1 stop7h 28m

$267

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Thu 11/27

7:00 am-1:44 pm

1 stop5h 44m

Knoxville McGhee Tyson

Sat 12/13

1:27 pm-5:27 pm

1 stop5h 00m

$277

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

Sun 11/9

8:00 pm-8:27 pm

1 stop23h 27m

Knoxville McGhee Tyson

Thu 11/13

12:38 pm-7:10 pm

1 stop7h 32m

$296

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

Tue 12/16

5:59 pm-6:12 pm

1 stop23h 13m

Knoxville McGhee Tyson

Fri 12/19

5:51 pm-9:49 am

1 stop16h 58m

$365

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Knoxville from

How to get the cheapest flight ticket from Missouri to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from Missouri, with most prices found around $266. If you aren’t able to travel during the month of July, then book flights to Knoxville from Missouri during April instead. Flights to Knoxville in April, while not as cheap as those in July, still average around $273.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Missouri to Knoxville is on a Thursday. Travelers who choose to depart for Knoxville on a Thursday will often find tickets for as low as $274. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Missouri to Knoxville for around $518.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Missouri to Knoxville when you can find flight prices for as low as $280. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $388.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $329 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Missouri for as low as $246 on momondo.

Cheap Missouri to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Knoxville

Direct flights

None
There are no direct flights from Missouri to Knoxville. There are no popular flight routes from Missouri to Knoxville.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Knoxville McGhee Tyson Airport?

    Prices for flights from Missouri to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Missouri to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Missouri to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Missouri to Knoxville

Compare and see reviews for airlines that fly from Missouri to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $198Free CancellationRating
7.4
8,997 reviews
Search United Airlines flights
American AirlinesPriceFrom $215Free CancellationRating
7.2
11,033 reviews
Search American Airlines flights
DeltaPriceFrom $228Free CancellationRating
7.9
7,996 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Missouri to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Missouri to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Missouri with this policy.

How can momondo help me find flights from Missouri to Knoxville?

momondo helps you find the best flight between Missouri and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Missouri to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Missouri are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 11/26
Wed 12/3
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States