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Cheap flights from Missouri to Knoxville from $117

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Knoxville departing on 4/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Missouri to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
4:35 pm - 2:58 pm
MCI
-
TYS
21h 23m
1 stop
Allegiant Air Logo
11:26 am - 7:54 am
TYS
-
MCI
21h 28m
1 stop
$212Allegiant Air
Mon, May 4 - Wed, May 6
United Airlines Logo
5:05 pm - 10:34 pm
MCI
-
TYS
4h 29m
1 stop
United Airlines Logo
7:00 am - 10:27 am
TYS
-
MCI
4h 27m
1 stop
$215United Airlines
Tue, Apr 21 - Tue, Apr 28
United Airlines Logo
6:15 am - 3:09 pm
MCI
-
TYS
7h 54m
2 stops
United Airlines Logo
7:00 am - 10:27 am
TYS
-
MCI
4h 27m
1 stop
$220United Airlines
Tue, Apr 21 - Tue, Apr 28
Southwest Logo
7:35 am - 12:00 pm
MCI
-
TYS
3h 25m
1 stop
Southwest Logo
5:50 pm - 10:40 pm
TYS
-
MCI
5h 50m
1 stop
$247Southwest
Tue, Apr 14 - Wed, Apr 15
Southwest Logo
12:20 pm - 8:50 pm
MCI
-
TYS
7h 30m
2 stops
Southwest Logo
5:50 pm - 10:40 pm
TYS
-
MCI
5h 50m
1 stop
$252Southwest
Tue, Apr 14 - Wed, Apr 15
Multiple Airlines Logo
11:13 am - 9:40 am
MCI
-
TYS
21h 27m
2 stops
Multiple Airlines Logo
11:26 am - 7:54 am
TYS
-
MCI
21h 28m
1 stop
$262Multiple Airlines
Mon, May 4 - Wed, May 6
American Airlines Logo
5:18 pm - 11:56 pm
STL
-
TYS
5h 38m
1 stop
American Airlines Logo
6:12 am - 10:37 am
TYS
-
STL
5h 25m
1 stop
$277American Airlines
Thu, May 28 - Tue, Jun 2
Delta Logo
5:00 pm - 11:54 pm
STL
-
TYS
5h 54m
1 stop
Delta Logo
5:40 am - 8:30 am
TYS
-
STL
3h 50m
1 stop
$285Delta
Sat, Apr 25 - Fri, May 1
American Airlines Logo
6:11 pm - 11:56 pm
STL
-
TYS
4h 45m
1 stop
American Airlines Logo
7:00 am - 12:48 pm
TYS
-
STL
6h 48m
1 stop
$298American Airlines
Fri, Apr 17 - Thu, Apr 23
Delta Logo
6:52 pm - 11:56 pm
SGF
-
TYS
4h 04m
1 stop
Delta Logo
5:59 pm - 10:19 pm
TYS
-
SGF
5h 20m
1 stop
$344Delta
Fri, May 8 - Tue, May 12

United Airlines flights from Missouri to Knoxville

Our best United Airlines deals on Missouri to Knoxville flight tickets
United Airlines
Apr 21
MCI5:05 pmKansas City
4h 29m
1 stop
TYS10:34 pmKnoxville McGhee Tyson
Apr 28
TYS7:00 amKnoxville McGhee Tyson
4h 27m
1 stop
MCI10:27 amKansas City
$215
United Airlines
Apr 21
MCI6:15 amKansas City
7h 54m
2 stops
TYS3:09 pmKnoxville McGhee Tyson
Apr 28
TYS7:00 amKnoxville McGhee Tyson
4h 27m
1 stop
MCI10:27 amKansas City
$220
United Airlines
May 4
MCI6:17 amKansas City
7h 17m
2 stops
TYS2:34 pmKnoxville McGhee Tyson
May 6
TYS7:00 amKnoxville McGhee Tyson
4h 33m
1 stop
MCI10:33 amKansas City
$241

American Airlines flights from Missouri to Knoxville

Our best American Airlines deals on Missouri to Knoxville flight tickets
American Airlines
May 28
STL5:18 pmLambert-St Louis
5h 38m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
Jun 2
TYS6:12 amKnoxville McGhee Tyson
5h 25m
1 stop
STL10:37 amLambert-St Louis
$277
American Airlines
May 17
STL6:29 amLambert-St Louis
5h 46m
1 stop
TYS1:15 pmKnoxville McGhee Tyson
May 21
TYS6:12 amKnoxville McGhee Tyson
5h 25m
1 stop
STL10:37 amLambert-St Louis
$299
American Airlines
Apr 10
COU5:21 pmColumbia Regional
5h 35m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
Apr 14
TYS6:00 amKnoxville McGhee Tyson
6h 35m
1 stop
COU11:35 amColumbia Regional
$308

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 30, 2026.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Mon 5/4

4:35 pm-2:58 pm

1 stop21h 23m

Knoxville McGhee Tyson

Wed 5/6

11:26 am-7:54 am

1 stop21h 28m

$212
Quickest round-trip

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Tue 4/21

5:05 pm-10:34 pm

1 stop4h 29m

Knoxville McGhee Tyson

Tue 4/28

7:00 am-10:27 am

1 stop4h 27m

$215

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Tue 4/21

6:15 am-3:09 pm

2 stops7h 54m

Knoxville McGhee Tyson

Tue 4/28

7:00 am-10:27 am

1 stop4h 27m

$220

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Tue 4/14

7:35 am-12:00 pm

1 stop3h 25m

Knoxville McGhee Tyson

Wed 4/15

5:50 pm-10:40 pm

1 stop5h 50m

$247

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Tue 4/14

12:20 pm-8:50 pm

2 stops7h 30m

Knoxville McGhee Tyson

Wed 4/15

5:50 pm-10:40 pm

1 stop5h 50m

$252

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Mon 5/4

11:13 am-9:40 am

2 stops21h 27m

Knoxville McGhee Tyson

Wed 5/6

11:26 am-7:54 am

1 stop21h 28m

$262

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 5/28

5:18 pm-11:56 pm

1 stop5h 38m

Knoxville McGhee Tyson

Tue 6/2

6:12 am-10:37 am

1 stop5h 25m

$277

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 4/25

5:00 pm-11:54 pm

1 stop5h 54m

Knoxville McGhee Tyson

Fri 5/1

5:40 am-8:30 am

1 stop3h 50m

$285

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 4/17

6:11 pm-11:56 pm

1 stop4h 45m

Knoxville McGhee Tyson

Thu 4/23

7:00 am-12:48 pm

1 stop6h 48m

$298

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

Fri 5/8

6:52 pm-11:56 pm

1 stop4h 04m

Knoxville McGhee Tyson

Tue 5/12

5:59 pm-10:19 pm

1 stop5h 20m

$344

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Missouri to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from Missouri, with most prices found around $273. If you aren’t able to travel during the month of July, then book flights to Knoxville from Missouri during August instead. Flights to Knoxville in August, while not as cheap as those in July, still average around $277.

Cheap Missouri to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Knoxville

Fastest flight time

2h 35m

Direct flights

None
The fastest flight from Missouri to Knoxville takes 2h 35m
There are no direct flights from Missouri to Knoxville. There are no popular flight routes from Missouri to Knoxville.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Knoxville McGhee Tyson Airport?

    Prices for flights from Missouri to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Missouri to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Missouri to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Missouri to Knoxville

Compare and see reviews for airlines that fly from Missouri to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $202Free CancellationRating
8.0
4,329 reviews
Search Southwest flights
American AirlinesPriceFrom $213Free CancellationRating
7.1
11,530 reviews
Search American Airlines flights
DeltaPriceFrom $228Free CancellationRating
7.9
8,359 reviews
Search Delta flights
United AirlinesPriceFrom $264Free CancellationRating
7.4
9,514 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Missouri to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Missouri to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Missouri with this policy.

How can momondo help me find flights from Missouri to Knoxville?

momondo helps you find the best flight between Missouri and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Missouri to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Missouri are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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