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Cheap flights from Missouri to Knoxville from $119

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Knoxville departing on 10/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Missouri to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:27 am - 12:30 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
4h 03m1 stop Chicago O'Hare Intl
American Airlines Logo
8:15 pm - 12:27 amTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
5h 12m1 stop Chicago O'Hare Intl
$205American Airlines
Sat, Sep 12 - Thu, Sep 17
American Airlines Logo
5:18 pm - 10:42 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
4h 24m1 stop Chicago O'Hare Intl
American Airlines Logo
7:18 pm - 10:42 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
4h 24m1 stop Charlotte Douglas
$205American Airlines
Wed, Sep 9 - Wed, Sep 16
United Airlines Logo
7:25 am - 1:18 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
4h 53m1 stop Chicago O'Hare Intl
United Airlines Logo
7:00 am - 12:02 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
6h 02m1 stop Chicago O'Hare Intl
$208United Airlines
Wed, Sep 2 - Sun, Sep 6
Southwest Logo
1:40 pm - 7:55 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
5h 15m1 stop Baltimore/Washington
Southwest Logo
7:00 am - 2:50 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
8h 50m2 stops Nashville Intl Baltimore/Washington
$210Southwest
Wed, Sep 9 - Wed, Sep 16
Southwest Logo
10:45 am - 7:55 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
8h 10m2 stops Chicago Midway Baltimore/Washington
Southwest Logo
7:00 am - 2:50 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
8h 50m2 stops Nashville Intl Baltimore/Washington
$215Southwest
Wed, Sep 9 - Wed, Sep 16
Allegiant Air Logo
10:39 am - 2:35 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
26h 56m1 stop Orlando Sanford Intl
Allegiant Air Logo
5:38 pm - 4:38 pmTYS  Knoxville McGhee Tyson-COU Columbia Regional
24h 00m1 stop Orlando Sanford Intl
$240Allegiant Air
Mon, Aug 31 - Thu, Sep 10
United Airlines Logo
1:29 pm - 8:49 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
6h 20m1 stop Chicago O'Hare Intl
United Airlines Logo
10:42 am - 3:43 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
6h 01m1 stop Chicago O'Hare Intl
$243United Airlines
Mon, Oct 5 - Thu, Oct 8
Allegiant Air Logo
9:59 am - 5:37 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
6h 38m1 stop Orlando Sanford Intl
Allegiant Air Logo
5:38 pm - 4:38 pmTYS  Knoxville McGhee Tyson-COU Columbia Regional
24h 00m1 stop Orlando Sanford Intl
$243Allegiant Air
Fri, Aug 28 - Thu, Sep 10
Delta Logo
5:37 pm - 10:22 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
3h 45m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 10:21 amTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
5h 21m1 stop Atlanta Hartsfield-Jackson
$250Delta
Mon, Nov 23 - Fri, Nov 27
Delta Logo
2:25 pm - 8:08 pmSTL  Lambert-St Louis-TYS Knoxville McGhee Tyson
4h 43m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:24 pm - 11:54 pmTYS  Knoxville McGhee Tyson-STL Lambert-St Louis
5h 30m1 stop Atlanta Hartsfield-Jackson
$259Delta
Mon, Oct 19 - Mon, Oct 26

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Allegiant Air flights from Missouri to Knoxville

Our best Allegiant Air deals on Missouri to Knoxville flight tickets
Allegiant Air
Aug 31
COU10:39 amColumbia Regional
26h 56m
1 stop
TYS2:35 pmKnoxville McGhee Tyson
Sep 10
TYS5:38 pmKnoxville McGhee Tyson
24h 00m
1 stop
COU4:38 pmColumbia Regional
$240
Allegiant Air
Aug 28
COU9:59 amColumbia Regional
6h 38m
1 stop
TYS5:37 pmKnoxville McGhee Tyson
Sep 10
TYS5:38 pmKnoxville McGhee Tyson
24h 00m
1 stop
COU4:38 pmColumbia Regional
$243
Allegiant Air
Aug 28
COU9:59 amColumbia Regional
6h 38m
1 stop
TYS5:37 pmKnoxville McGhee Tyson
Sep 6
TYS4:49 pmKnoxville McGhee Tyson
17h 55m
1 stop
COU9:44 amColumbia Regional
$246

Delta flights from Missouri to Knoxville

Our best Delta deals on Missouri to Knoxville flight tickets
Delta
Oct 19
STL2:25 pmLambert-St Louis
4h 43m
1 stop
TYS8:08 pmKnoxville McGhee Tyson
Oct 26
TYS7:24 pmKnoxville McGhee Tyson
5h 30m
1 stop
STL11:54 pmLambert-St Louis
$259
Delta
Oct 5
MCI5:30 pmKansas City
5h 25m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
Oct 9
TYS7:24 pmKnoxville McGhee Tyson
5h 32m
1 stop
MCI11:56 pmKansas City
$271
Delta
Aug 29
STL1:04 pmLambert-St Louis
6h 06m
1 stop
TYS8:10 pmKnoxville McGhee Tyson
Sep 10
TYS5:40 amKnoxville McGhee Tyson
4h 54m
1 stop
STL9:34 amLambert-St Louis
$274

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 17, 2026.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Sat 9/12

7:27 am-12:30 pm

1 stop4h 03m

Knoxville McGhee Tyson

Thu 9/17

8:15 pm-12:27 am

1 stop5h 12m

$205
Quickest round-trip

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Wed 9/9

5:18 pm-10:42 pm

1 stop4h 24m

Knoxville McGhee Tyson

Wed 9/16

7:18 pm-10:42 pm

1 stop4h 24m

$205

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Wed 9/2

7:25 am-1:18 pm

1 stop4h 53m

Knoxville McGhee Tyson

Sun 9/6

7:00 am-12:02 pm

1 stop6h 02m

$208

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Wed 9/9

1:40 pm-7:55 pm

1 stop5h 15m

Knoxville McGhee Tyson

Wed 9/16

7:00 am-2:50 pm

2 stops8h 50m

$210

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Wed 9/9

10:45 am-7:55 pm

2 stops8h 10m

Knoxville McGhee Tyson

Wed 9/16

7:00 am-2:50 pm

2 stops8h 50m

$215

ColumbiaKnoxville

COU Columbia Regional - TYS Knoxville McGhee Tyson

COUTYS

Columbia Regional

Mon 8/31

10:39 am-2:35 pm

1 stop26h 56m

Knoxville McGhee Tyson

Thu 9/10

5:38 pm-4:38 pm

1 stop24h 00m

$240

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Mon 10/5

1:29 pm-8:49 pm

1 stop6h 20m

Knoxville McGhee Tyson

Thu 10/8

10:42 am-3:43 pm

1 stop6h 01m

$243

ColumbiaKnoxville

COU Columbia Regional - TYS Knoxville McGhee Tyson

COUTYS

Columbia Regional

Fri 8/28

9:59 am-5:37 pm

1 stop6h 38m

Knoxville McGhee Tyson

Thu 9/10

5:38 pm-4:38 pm

1 stop24h 00m

$243

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Mon 11/23

5:37 pm-10:22 pm

1 stop3h 45m

Knoxville McGhee Tyson

Fri 11/27

6:00 am-10:21 am

1 stop5h 21m

$250

St. LouisKnoxville

STL Lambert-St Louis - TYS Knoxville McGhee Tyson

STLTYS

Lambert-St Louis

Mon 10/19

2:25 pm-8:08 pm

1 stop4h 43m

Knoxville McGhee Tyson

Mon 10/26

7:24 pm-11:54 pm

1 stop5h 30m

$259

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Missouri to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Missouri, with most prices found around $333. If you aren’t able to travel during the month of August, then book flights to Knoxville from Missouri during November instead. Flights to Knoxville in November, while not as cheap as those in August, still average around $338.

Can stopping save me money on Missouri to Knoxville flights?

You could potentially save up to 2% on your flight if you consider stops on a Missouri to Knoxville flight.

Cheap Missouri to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Knoxville

Best Price Found

$119

Fastest flight time

3h 20m

Direct flights

None
The best one-way flight to Knoxville from Missouri in the past 72 hours is $119. The best round-trip flight deal from Missouri to Knoxville found on momondo in the last 72 hours is $205.
The fastest flight from Missouri to Knoxville takes 3h 20m
There are no direct flights from Missouri to Knoxville. There are no popular flight routes from Missouri to Knoxville.
Search flight deals

Frequently asked questions about flying from Missouri to Knoxville

  • When did momondo last update prices for flights from Missouri to Knoxville McGhee Tyson Airport?

    Prices for flights from Missouri to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Missouri to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Missouri to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Missouri to Knoxville

Compare and see reviews for airlines that fly from Missouri to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $217Free CancellationRating
7.8
8,503 reviews
Search Delta flights
American AirlinesPriceFrom $228Free CancellationRating
7.1
11,944 reviews
Search American Airlines flights
SouthwestPriceFrom $248Free CancellationRating
8.0
4,218 reviews
Search Southwest flights
United AirlinesPriceFrom $256Free CancellationRating
7.4
10,106 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Alcoa
Corbin
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Missouri to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Missouri to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Missouri with this policy.

How can momondo help me find flights from Missouri to Knoxville?

momondo helps you find the best flight between Missouri and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Missouri to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Missouri are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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