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Cheap flights from Missouri to Knoxville from $107

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Knoxville departing on 6/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Missouri to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
1:45 pm - 7:36 pm
MCI
-
TYS
28h 51m
1 stop
Frontier Logo
8:32 pm - 12:55 pm
TYS
-
MCI
17h 23m
1 stop
$262Frontier
Thu, Aug 6 - Mon, Aug 10
Multiple Airlines Logo
4:19 pm - 11:37 pm
STL
-
TYS
6h 18m
1 stop
Multiple Airlines Logo
1:02 pm - 5:33 pm
TYS
-
STL
29h 31m
2 stops
$268Multiple Airlines
Mon, Jun 1 - Wed, Jun 3
American Airlines Logo
5:29 am - 1:02 pm
STL
-
TYS
6h 33m
1 stop
American Airlines Logo
5:33 pm - 11:59 pm
TYS
-
STL
7h 26m
1 stop
$269American Airlines
Tue, Jun 16 - Tue, Jun 23
Multiple Airlines Logo
10:40 am - 11:31 pm
MCI
-
TYS
11h 51m
1 stop
Multiple Airlines Logo
6:30 am - 12:55 pm
TYS
-
MCI
31h 25m
2 stops
$269Multiple Airlines
Mon, Aug 10 - Fri, Aug 14
Southwest Logo
1:20 pm - 9:15 pm
STL
-
TYS
6h 55m
1 stop
Southwest Logo
7:10 am - 1:05 pm
TYS
-
STL
6h 55m
2 stops
$274Southwest
Tue, Jun 9 - Tue, Jun 16
American Airlines Logo
7:01 am - 1:02 pm
STL
-
TYS
5h 01m
1 stop
American Airlines Logo
7:59 pm - 11:44 pm
TYS
-
STL
4h 45m
1 stop
$279American Airlines
Sat, Jun 6 - Wed, Jun 10
Southwest Logo
11:20 am - 8:20 pm
STL
-
TYS
8h 00m
2 stops
Southwest Logo
7:10 am - 1:05 pm
TYS
-
STL
6h 55m
2 stops
$280Southwest
Tue, Jun 9 - Tue, Jun 16
Frontier Logo
1:45 pm - 7:36 pm
MCI
-
TYS
28h 51m
1 stop
Frontier Logo
8:32 pm - 12:55 pm
TYS
-
MCI
17h 23m
1 stop
$282Frontier
Thu, Jul 9 - Mon, Jul 13
Allegiant Air Logo
10:40 am - 11:12 pm
MCI
-
TYS
11h 32m
1 stop
Allegiant Air Logo
2:14 pm - 2:19 pm
TYS
-
MCI
25h 05m
1 stop
$288Allegiant Air
Fri, Jun 12 - Sun, Jun 14
Allegiant Air Logo
8:56 am - 11:12 pm
SGF
-
TYS
13h 16m
1 stop
Allegiant Air Logo
2:14 pm - 8:07 pm
TYS
-
SGF
6h 53m
1 stop
$294Allegiant Air
Fri, Jun 12 - Sun, Jun 14

Allegiant Air flights from Missouri to Knoxville

Our best Allegiant Air deals on Missouri to Knoxville flight tickets
Allegiant Air
Jun 12
MCI10:40 amKansas City
11h 32m
1 stop
TYS11:12 pmKnoxville McGhee Tyson
Jun 14
TYS2:14 pmKnoxville McGhee Tyson
25h 05m
1 stop
MCI2:19 pmKansas City
$288
Allegiant Air
Jun 12
SGF8:56 amSpringfield-Branson
13h 16m
1 stop
TYS11:12 pmKnoxville McGhee Tyson
Jun 14
TYS2:14 pmKnoxville McGhee Tyson
6h 53m
1 stop
SGF8:07 pmSpringfield-Branson
$294
Allegiant Air
Jul 17
MCI10:40 amKansas City
11h 39m
1 stop
TYS11:19 pmKnoxville McGhee Tyson
Jul 19
TYS2:08 pmKnoxville McGhee Tyson
25h 05m
1 stop
MCI2:13 pmKansas City
$296

American Airlines flights from Missouri to Knoxville

Our best American Airlines deals on Missouri to Knoxville flight tickets
American Airlines
Jun 16
STL5:29 amLambert-St Louis
6h 33m
1 stop
TYS1:02 pmKnoxville McGhee Tyson
Jun 23
TYS5:33 pmKnoxville McGhee Tyson
7h 26m
1 stop
STL11:59 pmLambert-St Louis
$269
American Airlines
Jun 6
STL7:01 amLambert-St Louis
5h 01m
1 stop
TYS1:02 pmKnoxville McGhee Tyson
Jun 10
TYS7:59 pmKnoxville McGhee Tyson
4h 45m
1 stop
STL11:44 pmLambert-St Louis
$279
American Airlines
Jun 10
STL11:18 amLambert-St Louis
6h 20m
1 stop
TYS6:38 pmKnoxville McGhee Tyson
Jun 13
TYS5:33 pmKnoxville McGhee Tyson
7h 26m
1 stop
STL11:59 pmLambert-St Louis
$284

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 13, 2026.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Thu 8/6

1:45 pm-7:36 pm

1 stop28h 51m

Knoxville McGhee Tyson

Mon 8/10

8:32 pm-12:55 pm

1 stop17h 23m

$262

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 6/1

4:19 pm-11:37 pm

1 stop6h 18m

Knoxville McGhee Tyson

Wed 6/3

1:02 pm-5:33 pm

2 stops29h 31m

$268

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 6/16

5:29 am-1:02 pm

1 stop6h 33m

Knoxville McGhee Tyson

Tue 6/23

5:33 pm-11:59 pm

1 stop7h 26m

$269

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Mon 8/10

10:40 am-11:31 pm

1 stop11h 51m

Knoxville McGhee Tyson

Fri 8/14

6:30 am-12:55 pm

2 stops31h 25m

$269

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 6/9

1:20 pm-9:15 pm

1 stop6h 55m

Knoxville McGhee Tyson

Tue 6/16

7:10 am-1:05 pm

2 stops6h 55m

$274
Quickest round-trip

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 6/6

7:01 am-1:02 pm

1 stop5h 01m

Knoxville McGhee Tyson

Wed 6/10

7:59 pm-11:44 pm

1 stop4h 45m

$279

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 6/9

11:20 am-8:20 pm

2 stops8h 00m

Knoxville McGhee Tyson

Tue 6/16

7:10 am-1:05 pm

2 stops6h 55m

$280

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Thu 7/9

1:45 pm-7:36 pm

1 stop28h 51m

Knoxville McGhee Tyson

Mon 7/13

8:32 pm-12:55 pm

1 stop17h 23m

$282

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Fri 6/12

10:40 am-11:12 pm

1 stop11h 32m

Knoxville McGhee Tyson

Sun 6/14

2:14 pm-2:19 pm

1 stop25h 05m

$288

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

Fri 6/12

8:56 am-11:12 pm

1 stop13h 16m

Knoxville McGhee Tyson

Sun 6/14

2:14 pm-8:07 pm

1 stop6h 53m

$294

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Missouri to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Missouri, with most prices found around $75. If you aren’t able to travel during the month of August, then book flights to Knoxville from Missouri during November instead. Flights to Knoxville in November, while not as cheap as those in August, still average around $133.

Cheap Missouri to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Knoxville

Fastest flight time

3h 57m

Direct flights

None
The fastest flight from Missouri to Knoxville takes 3h 57m
There are no direct flights from Missouri to Knoxville. There are no popular flight routes from Missouri to Knoxville.
Search flight deals

Frequently asked questions about flying from Missouri to Knoxville

  • When did momondo last update prices for flights from Missouri to Knoxville McGhee Tyson Airport?

    Prices for flights from Missouri to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Missouri to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Missouri to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Missouri to Knoxville

Compare and see reviews for airlines that fly from Missouri to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $202Free CancellationRating
7.9
4,296 reviews
Search Southwest flights
American AirlinesPriceFrom $213Free CancellationRating
7.1
11,662 reviews
Search American Airlines flights
DeltaPriceFrom $228Free CancellationRating
7.9
8,450 reviews
Search Delta flights
United AirlinesPriceFrom $256Free CancellationRating
7.4
9,706 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Missouri to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Missouri to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Missouri with this policy.

How can momondo help me find flights from Missouri to Knoxville?

momondo helps you find the best flight between Missouri and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Missouri to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Missouri are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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