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Cheap flights from Missouri to Knoxville from $113

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Knoxville departing on 2/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Missouri to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:20 pm - 10:09 pm
STL
-
TYS
5h 49m1 stop
American Airlines Logo
4:00 pm - 9:51 pm
TYS
-
STL
6h 51m2 stops
$230American Airlines
Tue, Jan 13 - Tue, Jan 20
Multiple Airlines Logo
3:43 pm - 10:10 am
STL
-
TYS
17h 27m2 stops
Multiple Airlines Logo
12:30 pm - 10:33 pm
TYS
-
STL
11h 03m1 stop
$247Multiple Airlines
Thu, Jan 8 - Sat, Jan 10
American Airlines Logo
5:14 am - 11:27 am
STL
-
TYS
5h 13m1 stop
American Airlines Logo
5:00 am - 8:32 am
TYS
-
STL
4h 32m1 stop
$249American Airlines
Wed, Feb 18 - Sun, Feb 22
American Airlines Logo
10:17 am - 3:20 pm
STL
-
TYS
4h 03m1 stop
American Airlines Logo
6:51 pm - 10:59 pm
TYS
-
STL
5h 08m1 stop
$251American Airlines
Tue, Jan 13 - Tue, Jan 20
Multiple Airlines Logo
5:11 pm - 10:10 am
STL
-
TYS
15h 59m1 stop
Multiple Airlines Logo
12:30 pm - 10:33 pm
TYS
-
STL
11h 03m1 stop
$252Multiple Airlines
Thu, Jan 8 - Sat, Jan 10
Allegiant Air Logo
11:37 am - 9:37 pm
MCI
-
TYS
9h 00m1 stop
Allegiant Air Logo
3:53 pm - 8:09 am
TYS
-
MCI
17h 16m1 stop
$259Allegiant Air
Mon, Jan 5 - Wed, Jan 7
Delta Logo
6:00 am - 11:08 am
STL
-
TYS
4h 08m1 stop
Delta Logo
5:40 am - 8:53 am
TYS
-
STL
4h 13m1 stop
$265Delta
Wed, Jan 28 - Fri, Jan 30
United Airlines Logo
8:09 am - 1:24 pm
COU
-
TYS
4h 15m1 stop
United Airlines Logo
11:10 am - 2:35 pm
TYS
-
COU
4h 25m1 stop
$298United Airlines
Sat, Jan 24 - Wed, Jan 28
United Airlines Logo
3:10 pm - 8:52 pm
COU
-
TYS
4h 42m1 stop
United Airlines Logo
2:25 pm - 9:37 pm
TYS
-
COU
8h 12m2 stops
$304United Airlines
Sat, Jan 24 - Wed, Jan 28
Delta Logo
4:48 pm - 11:51 pm
MCI
-
TYS
6h 03m1 stop
Delta Logo
5:30 am - 9:15 am
TYS
-
MCI
4h 45m1 stop
$337Delta
Mon, Mar 9 - Fri, Mar 13

American Airlines flights from Missouri to Knoxville

Our best American Airlines deals on Missouri to Knoxville flight tickets
American Airlines
Feb 18
STL5:14 amLambert-St Louis
5h 13m
1 stop
TYS11:27 amKnoxville McGhee Tyson
Feb 22
TYS5:00 amKnoxville McGhee Tyson
4h 32m
1 stop
STL8:32 amLambert-St Louis
$249
Find similar
American Airlines
Jan 13
STL3:20 pmLambert-St Louis
6h 34m
2 stops
TYS10:54 pmKnoxville McGhee Tyson
Jan 17
TYS7:11 pmKnoxville McGhee Tyson
5h 15m
1 stop
STL11:26 pmLambert-St Louis
$274
Find similar
American Airlines
Feb 6
STL9:54 amLambert-St Louis
5h 02m
1 stop
TYS3:56 pmKnoxville McGhee Tyson
Feb 9
TYS5:14 pmKnoxville McGhee Tyson
6h 58m
1 stop
STL11:12 pmLambert-St Louis
$279
Find similar

Delta flights from Missouri to Knoxville

Our best Delta deals on Missouri to Knoxville flight tickets
Delta
Jan 28
STL6:00 amLambert-St Louis
4h 08m
1 stop
TYS11:08 amKnoxville McGhee Tyson
Jan 30
TYS5:40 amKnoxville McGhee Tyson
4h 13m
1 stop
STL8:53 amLambert-St Louis
$265
Find similar
Delta
Mar 9
MCI4:48 pmKansas City
6h 03m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
Mar 13
TYS5:30 amKnoxville McGhee Tyson
4h 45m
1 stop
MCI9:15 amKansas City
$337
Find similar
Delta
May 8
SGF6:45 pmSpringfield-Branson
4h 01m
1 stop
TYS11:46 pmKnoxville McGhee Tyson
May 12
TYS5:30 amKnoxville McGhee Tyson
6h 37m
1 stop
SGF11:07 amSpringfield-Branson
$369
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 1/13

3:20 pm-10:09 pm

1 stop5h 49m

Knoxville McGhee Tyson

Tue 1/20

4:00 pm-9:51 pm

2 stops6h 51m

$230

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 1/8

3:43 pm-10:10 am

2 stops17h 27m

Knoxville McGhee Tyson

Sat 1/10

12:30 pm-10:33 pm

1 stop11h 03m

$247

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 2/18

5:14 am-11:27 am

1 stop5h 13m

Knoxville McGhee Tyson

Sun 2/22

5:00 am-8:32 am

1 stop4h 32m

$249

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 1/13

10:17 am-3:20 pm

1 stop4h 03m

Knoxville McGhee Tyson

Tue 1/20

6:51 pm-10:59 pm

1 stop5h 08m

$251

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 1/8

5:11 pm-10:10 am

1 stop15h 59m

Knoxville McGhee Tyson

Sat 1/10

12:30 pm-10:33 pm

1 stop11h 03m

$252

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Mon 1/5

11:37 am-9:37 pm

1 stop9h 00m

Knoxville McGhee Tyson

Wed 1/7

3:53 pm-8:09 am

1 stop17h 16m

$259

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 1/28

6:00 am-11:08 am

1 stop4h 08m

Knoxville McGhee Tyson

Fri 1/30

5:40 am-8:53 am

1 stop4h 13m

$265

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 1/24

8:09 am-1:24 pm

1 stop4h 15m

Knoxville McGhee Tyson

Wed 1/28

11:10 am-2:35 pm

1 stop4h 25m

$298

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 1/24

3:10 pm-8:52 pm

1 stop4h 42m

Knoxville McGhee Tyson

Wed 1/28

2:25 pm-9:37 pm

2 stops8h 12m

$304

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Mon 3/9

4:48 pm-11:51 pm

1 stop6h 03m

Knoxville McGhee Tyson

Fri 3/13

5:30 am-9:15 am

1 stop4h 45m

$337

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Missouri to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from Missouri, with most prices found around $266. If you aren’t able to travel during the month of July, then book flights to Knoxville from Missouri during April instead. Flights to Knoxville in April, while not as cheap as those in July, still average around $273.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Missouri to Knoxville is on a Thursday. Travelers who choose to depart for Knoxville on a Thursday will often find tickets for as low as $274. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Missouri to Knoxville for around $518.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Missouri to Knoxville when you can find flight prices for as low as $280. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $388.

Cheap Missouri to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Knoxville

Fastest flight time

3h 14m

Direct flights

None
The fastest flight from Missouri to Knoxville takes 3h 14m
There are no direct flights from Missouri to Knoxville. There are no popular flight routes from Missouri to Knoxville.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Knoxville McGhee Tyson Airport?

    Prices for flights from Missouri to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Missouri to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Missouri to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Missouri to Knoxville

Compare and see reviews for airlines that fly from Missouri to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $198Free CancellationRating
7.4
9,091 reviews
Search United Airlines flights
American AirlinesPriceFrom $198Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights
DeltaPriceFrom $222Free CancellationRating
7.9
8,005 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Missouri to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Missouri to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Missouri with this policy.

How can momondo help me find flights from Missouri to Knoxville?

momondo helps you find the best flight between Missouri and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Missouri to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Missouri are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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