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Cheap flights from Missouri to Knoxville from $117

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Knoxville departing on 5/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Missouri to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
3:49 pm - 6:26 pm
STL
-
TYS
25h 37m
1 stop
Multiple Airlines Logo
10:00 am - 11:19 pm
TYS
-
STL
14h 19m
1 stop
$197Multiple Airlines
Tue, Mar 3 - Tue, Mar 10
Multiple Airlines Logo
3:49 pm - 6:26 pm
STL
-
TYS
25h 37m
1 stop
Multiple Airlines Logo
11:00 am - 10:37 am
TYS
-
STL
24h 37m
2 stops
$214Multiple Airlines
Tue, Mar 3 - Tue, Mar 10
United Airlines Logo
3:10 pm - 8:37 pm
COU
-
TYS
4h 27m
1 stop
United Airlines Logo
6:45 am - 10:33 am
TYS
-
COU
4h 48m
1 stop
$248United Airlines
Sat, Feb 21 - Wed, Feb 25
Delta Logo
7:10 am - 1:51 pm
STL
-
TYS
5h 41m
1 stop
Delta Logo
5:40 am - 11:09 am
TYS
-
STL
6h 29m
1 stop
$251Delta
Wed, Mar 4 - Wed, Mar 11
Southwest Logo
7:30 am - 11:50 am
STL
-
TYS
3h 20m
1 stop
Southwest Logo
7:25 pm - 12:15 am
TYS
-
STL
5h 50m
1 stop
$256Southwest
Wed, Mar 11 - Sun, Mar 15
Southwest Logo
2:30 pm - 7:40 pm
STL
-
TYS
4h 10m
1 stop
Southwest Logo
6:35 am - 12:30 pm
TYS
-
STL
6h 55m
2 stops
$261Southwest
Tue, Apr 7 - Fri, Apr 10
Delta Logo
10:48 am - 5:08 pm
MCI
-
TYS
5h 20m
1 stop
Delta Logo
5:54 pm - 10:11 pm
TYS
-
MCI
5h 17m
1 stop
$267Delta
Tue, Apr 21 - Tue, Apr 28
United Airlines Logo
3:10 pm - 8:37 pm
COU
-
TYS
4h 27m
1 stop
United Airlines Logo
6:45 am - 10:33 am
TYS
-
COU
4h 48m
1 stop
$268United Airlines
Sat, Feb 21 - Sat, Feb 28
American Airlines Logo
6:11 pm - 11:56 pm
STL
-
TYS
4h 45m
1 stop
American Airlines Logo
7:00 am - 12:48 pm
TYS
-
STL
6h 48m
1 stop
$278American Airlines
Mon, Apr 13 - Sun, Apr 19
American Airlines Logo
4:47 pm - 11:50 pm
SGF
-
TYS
6h 03m
1 stop
American Airlines Logo
5:40 am - 11:35 am
TYS
-
SGF
6h 55m
1 stop
$294American Airlines
Thu, Apr 2 - Sun, Apr 5

American Airlines flights from Missouri to Knoxville

Our best American Airlines deals on Missouri to Knoxville flight tickets
American Airlines
Mar 4
STL11:46 amLambert-St Louis
4h 45m
1 stop
TYS5:31 pmKnoxville McGhee Tyson
Mar 11
TYS11:42 amKnoxville McGhee Tyson
4h 53m
1 stop
STL3:35 pmLambert-St Louis
$233
American Airlines
Apr 13
STL6:11 pmLambert-St Louis
4h 45m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
Apr 19
TYS7:00 amKnoxville McGhee Tyson
6h 48m
1 stop
STL12:48 pmLambert-St Louis
$278
American Airlines
Apr 2
SGF4:47 pmSpringfield-Branson
6h 03m
1 stop
TYS11:50 pmKnoxville McGhee Tyson
Apr 5
TYS5:40 amKnoxville McGhee Tyson
6h 55m
1 stop
SGF11:35 amSpringfield-Branson
$294

Delta flights from Missouri to Knoxville

Our best Delta deals on Missouri to Knoxville flight tickets
Delta
Mar 4
STL7:10 amLambert-St Louis
5h 41m
1 stop
TYS1:51 pmKnoxville McGhee Tyson
Mar 11
TYS5:40 amKnoxville McGhee Tyson
6h 29m
1 stop
STL11:09 amLambert-St Louis
$251
Delta
Apr 21
MCI5:40 amKansas City
4h 37m
1 stop
TYS11:17 amKnoxville McGhee Tyson
Apr 28
TYS5:54 pmKnoxville McGhee Tyson
5h 17m
1 stop
MCI10:11 pmKansas City
$267
Delta
Mar 25
MCI5:54 amKansas City
4h 23m
1 stop
TYS11:17 amKnoxville McGhee Tyson
Mar 30
TYS6:38 pmKnoxville McGhee Tyson
4h 26m
1 stop
MCI10:04 pmKansas City
$279

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 3/3

3:49 pm-6:26 pm

1 stop25h 37m

Knoxville McGhee Tyson

Tue 3/10

10:00 am-11:19 pm

1 stop14h 19m

$197

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 3/3

3:49 pm-6:26 pm

1 stop25h 37m

Knoxville McGhee Tyson

Tue 3/10

11:00 am-10:37 am

2 stops24h 37m

$214

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 2/21

3:10 pm-8:37 pm

1 stop4h 27m

Knoxville McGhee Tyson

Wed 2/25

6:45 am-10:33 am

1 stop4h 48m

$248

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 3/4

7:10 am-1:51 pm

1 stop5h 41m

Knoxville McGhee Tyson

Wed 3/11

5:40 am-11:09 am

1 stop6h 29m

$251

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 3/11

7:30 am-11:50 am

1 stop3h 20m

Knoxville McGhee Tyson

Sun 3/15

7:25 pm-12:15 am

1 stop5h 50m

$256

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 4/7

2:30 pm-7:40 pm

1 stop4h 10m

Knoxville McGhee Tyson

Fri 4/10

6:35 am-12:30 pm

2 stops6h 55m

$261

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Tue 4/21

10:48 am-5:08 pm

1 stop5h 20m

Knoxville McGhee Tyson

Tue 4/28

5:54 pm-10:11 pm

1 stop5h 17m

$267

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Sat 2/21

3:10 pm-8:37 pm

1 stop4h 27m

Knoxville McGhee Tyson

Sat 2/28

6:45 am-10:33 am

1 stop4h 48m

$268

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Mon 4/13

6:11 pm-11:56 pm

1 stop4h 45m

Knoxville McGhee Tyson

Sun 4/19

7:00 am-12:48 pm

1 stop6h 48m

$278

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

Thu 4/2

4:47 pm-11:50 pm

1 stop6h 03m

Knoxville McGhee Tyson

Sun 4/5

5:40 am-11:35 am

1 stop6h 55m

$294

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Missouri to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from Missouri, with most prices found around $266. If you aren’t able to travel during the month of July, then book flights to Knoxville from Missouri during August instead. Flights to Knoxville in August, while not as cheap as those in July, still average around $277.

Cheap Missouri to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Knoxville

Fastest flight time

3h 05m

Direct flights

None
The fastest flight from Missouri to Knoxville takes 3h 05m
There are no direct flights from Missouri to Knoxville. There are no popular flight routes from Missouri to Knoxville.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Knoxville McGhee Tyson Airport?

    Prices for flights from Missouri to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Missouri to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Missouri to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Missouri to Knoxville

Compare and see reviews for airlines that fly from Missouri to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $198Free CancellationRating
7.4
9,263 reviews
Search United Airlines flights
American AirlinesPriceFrom $213Free CancellationRating
7.2
11,258 reviews
Search American Airlines flights
DeltaPriceFrom $222Free CancellationRating
7.9
8,176 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Alcoa
Crossville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Missouri to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Missouri to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Missouri with this policy.

How can momondo help me find flights from Missouri to Knoxville?

momondo helps you find the best flight between Missouri and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Missouri to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Missouri are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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