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Cheap flights from Missouri to Knoxville from $106

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Knoxville departing on 7/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Missouri to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:00 am - 11:01 am
STL
-
TYS
4h 01m
1 stop
Delta Logo
5:45 am - 8:49 am
TYS
-
STL
4h 04m
1 stop
$211Delta
Tue, Oct 27 - Tue, Nov 3
Southwest Logo
8:35 am - 2:20 pm
STL
-
TYS
4h 45m
1 stop
Southwest Logo
7:00 am - 3:10 pm
TYS
-
STL
9h 10m
2 stops
$216Southwest
Wed, Sep 9 - Wed, Sep 16
Southwest Logo
10:45 am - 7:50 pm
STL
-
TYS
8h 05m
2 stops
Southwest Logo
7:00 am - 2:50 pm
TYS
-
STL
8h 50m
2 stops
$221Southwest
Wed, Sep 9 - Wed, Sep 16
Frontier Logo
1:45 pm - 7:24 pm
MCI
-
TYS
28h 39m
1 stop
Frontier Logo
8:19 pm - 1:00 pm
TYS
-
MCI
17h 41m
1 stop
$259Frontier
Thu, Jul 30 - Mon, Aug 3
Multiple Airlines Logo
10:40 am - 11:31 pm
MCI
-
TYS
11h 51m
1 stop
Multiple Airlines Logo
3:56 pm - 5:10 pm
TYS
-
MCI
26h 14m
2 stops
$268Multiple Airlines
Mon, Aug 10 - Thu, Aug 13
American Airlines Logo
12:43 pm - 6:22 pm
COU
-
TYS
4h 39m
1 stop
American Airlines Logo
6:03 am - 11:16 am
TYS
-
COU
6h 13m
1 stop
$278American Airlines
Thu, Aug 6 - Sun, Aug 9
Multiple Airlines Logo
7:09 pm - 12:51 pm
MCI
-
TYS
16h 42m
1 stop
Multiple Airlines Logo
7:00 am - 1:00 pm
TYS
-
MCI
7h 00m
1 stop
$281Multiple Airlines
Thu, Aug 13 - Sun, Aug 16
Allegiant Air Logo
8:55 am - 7:50 pm
SGF
-
TYS
9h 55m
1 stop
Allegiant Air Logo
6:18 pm - 9:28 am
TYS
-
SGF
16h 10m
1 stop
$283Allegiant Air
Fri, Oct 30 - Sat, Oct 31
Allegiant Air Logo
11:44 am - 6:25 pm
COU
-
TYS
5h 41m
1 stop
Allegiant Air Logo
2:08 pm - 9:16 am
TYS
-
COU
20h 08m
1 stop
$284Allegiant Air
Wed, Jul 22 - Sun, Jul 26
American Airlines Logo
5:00 am - 11:10 am
MCI
-
TYS
5h 10m
1 stop
American Airlines Logo
6:03 am - 10:30 am
TYS
-
MCI
5h 27m
1 stop
$291American Airlines
Mon, Aug 10 - Thu, Aug 13

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Delta flights from Missouri to Knoxville

Our best Delta deals on Missouri to Knoxville flight tickets
Delta
Oct 27
STL6:00 amLambert-St Louis
4h 01m
1 stop
TYS11:01 amKnoxville McGhee Tyson
Nov 3
TYS5:45 amKnoxville McGhee Tyson
4h 04m
1 stop
STL8:49 amLambert-St Louis
$211
Delta
Oct 26
STL7:10 amLambert-St Louis
5h 30m
1 stop
TYS1:40 pmKnoxville McGhee Tyson
Nov 4
TYS2:38 pmKnoxville McGhee Tyson
4h 37m
1 stop
STL6:15 pmLambert-St Louis
$224
Delta
Oct 19
STL7:10 amLambert-St Louis
5h 30m
1 stop
TYS1:40 pmKnoxville McGhee Tyson
Oct 22
TYS2:38 pmKnoxville McGhee Tyson
4h 37m
1 stop
STL6:15 pmLambert-St Louis
$237

Allegiant Air flights from Missouri to Knoxville

Our best Allegiant Air deals on Missouri to Knoxville flight tickets
Allegiant Air
Oct 30
SGF8:55 amSpringfield-Branson
9h 55m
1 stop
TYS7:50 pmKnoxville McGhee Tyson
Oct 31
TYS6:18 pmKnoxville McGhee Tyson
16h 10m
1 stop
SGF9:28 amSpringfield-Branson
$283
Allegiant Air
Jul 22
COU11:44 amColumbia Regional
5h 41m
1 stop
TYS6:25 pmKnoxville McGhee Tyson
Jul 26
TYS2:08 pmKnoxville McGhee Tyson
20h 08m
1 stop
COU9:16 amColumbia Regional
$284
Allegiant Air
Oct 27
SGF10:48 amSpringfield-Branson
27h 51m
1 stop
TYS3:39 pmKnoxville McGhee Tyson
Oct 31
TYS6:18 pmKnoxville McGhee Tyson
16h 10m
1 stop
SGF9:28 amSpringfield-Branson
$294

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 4, 2026.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 10/27

6:00 am-11:01 am

1 stop4h 01m

Knoxville McGhee Tyson

Tue 11/3

5:45 am-8:49 am

1 stop4h 04m

$211

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 9/9

8:35 am-2:20 pm

1 stop4h 45m

Knoxville McGhee Tyson

Wed 9/16

7:00 am-3:10 pm

2 stops9h 10m

$216

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 9/9

10:45 am-7:50 pm

2 stops8h 05m

Knoxville McGhee Tyson

Wed 9/16

7:00 am-2:50 pm

2 stops8h 50m

$221

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Thu 7/30

1:45 pm-7:24 pm

1 stop28h 39m

Knoxville McGhee Tyson

Mon 8/3

8:19 pm-1:00 pm

1 stop17h 41m

$259

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Mon 8/10

10:40 am-11:31 pm

1 stop11h 51m

Knoxville McGhee Tyson

Thu 8/13

3:56 pm-5:10 pm

2 stops26h 14m

$268

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Thu 8/6

12:43 pm-6:22 pm

1 stop4h 39m

Knoxville McGhee Tyson

Sun 8/9

6:03 am-11:16 am

1 stop6h 13m

$278

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Thu 8/13

7:09 pm-12:51 pm

1 stop16h 42m

Knoxville McGhee Tyson

Sun 8/16

7:00 am-1:00 pm

1 stop7h 00m

$281

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

Fri 10/30

8:55 am-7:50 pm

1 stop9h 55m

Knoxville McGhee Tyson

Sat 10/31

6:18 pm-9:28 am

1 stop16h 10m

$283

ColumbiaKnoxville

COU - TYS

COUTYS

Columbia Regional

Wed 7/22

11:44 am-6:25 pm

1 stop5h 41m

Knoxville McGhee Tyson

Sun 7/26

2:08 pm-9:16 am

1 stop20h 08m

$284

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Mon 8/10

5:00 am-11:10 am

1 stop5h 10m

Knoxville McGhee Tyson

Thu 8/13

6:03 am-10:30 am

1 stop5h 27m

$291

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Missouri to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Missouri, with most prices found around $75. If you aren’t able to travel during the month of August, then book flights to Knoxville from Missouri during November instead. Flights to Knoxville in November, while not as cheap as those in August, still average around $133.

Can stopping save me money on Missouri to Knoxville flights?

You could potentially save up to 16% on your flight if you consider stops on a Missouri to Knoxville flight.

Cheap Missouri to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Knoxville

Fastest flight time

4h 01m

Direct flights

None
The fastest flight from Missouri to Knoxville takes 4h 01m
There are no direct flights from Missouri to Knoxville. There are no popular flight routes from Missouri to Knoxville.
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Frequently asked questions about flying from Missouri to Knoxville

  • When did momondo last update prices for flights from Missouri to Knoxville McGhee Tyson Airport?

    Prices for flights from Missouri to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Missouri to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Missouri to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Missouri to Knoxville

Compare and see reviews for airlines that fly from Missouri to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $235Free CancellationRating
7.1
11,765 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.8
8,454 reviews
Search Delta flights
United AirlinesPriceFrom $256Free CancellationRating
7.4
9,930 reviews
Search United Airlines flights
SouthwestPriceFrom $278Free CancellationRating
7.9
4,250 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Missouri to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Missouri to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Missouri with this policy.

How can momondo help me find flights from Missouri to Knoxville?

momondo helps you find the best flight between Missouri and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Missouri to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Missouri are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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