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Cheap flights from Milwaukee to South Carolina from $120

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Milwaukee to South Carolina departing on 11/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Milwaukee to South Carolina

Cheap round-trip flights

United Airlines Logo
6:05 am - 11:47 amMKE-GSP
4h 42m1 stop
United Airlines Logo
5:28 pm - 10:43 pmGSP-MKE
6h 15m1 stop
$243United Airlines
Find Deal
Tue, Oct 28 - Tue, Oct 28
American Airlines Logo
6:45 am - 1:40 pmMKE-GSP
5h 55m2 stops
American Airlines Logo
7:11 pm - 11:30 pmGSP-MKE
5h 19m1 stop
$248American Airlines
Find Deal
Tue, Oct 28 - Tue, Oct 28
Delta Logo
12:06 pm - 8:01 pmMKE-CAE
6h 55m1 stop
Delta Logo
7:55 pm - 11:55 pmCAE-MKE
5h 00m1 stop
$249Delta
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Sat, Oct 18 - Mon, Oct 20
Delta Logo
5:00 pm - 10:05 pmMKE-GSP
4h 05m1 stop
Delta Logo
5:45 am - 11:18 amGSP-MKE
6h 33m1 stop
$250Delta
Find Deal
Sat, Feb 28 - Wed, Mar 4
Southwest Logo
2:05 pm - 7:40 pmMKE-SAV
4h 35m1 stop
Southwest Logo
7:35 pm - 10:25 pmSAV-MKE
3h 50m1 stop
$263Southwest
Find Deal
Sat, Oct 4 - Tue, Oct 7
Southwest Logo
5:10 pm - 10:55 pmMKE-SAV
4h 45m1 stop
Southwest Logo
5:35 pm - 9:45 pmSAV-MKE
5h 10m1 stop
$266Southwest
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Fri, Nov 7 - Tue, Nov 11
Spirit Airlines Logo
1:55 pm - 7:47 amMKE-CLT
16h 52m1 stop
Spirit Airlines Logo
2:40 pm - 12:42 pmCLT-MKE
23h 02m1 stop
$275Spirit Airlines
Find Deal
Sun, Oct 5 - Wed, Oct 8
Logo
1:55 pm - 7:47 amMKE-CLT
16h 52m1 stop
Logo
6:07 pm - 7:19 pmCLT-MKE
26h 12m1 stop
$299
Find Deal
Thu, Oct 30 - Sun, Nov 2
Spirit Airlines Logo
1:55 pm - 10:28 pmMKE-CLT
7h 33m1 stop
Spirit Airlines Logo
6:00 am - 12:42 pmCLT-MKE
31h 42m2 stops
$313Spirit Airlines
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Sun, Oct 12 - Wed, Oct 15
Logo
1:55 pm - 7:47 amMKE-CLT
16h 52m1 stop
Logo
2:14 pm - 12:42 pmCLT-MKE
23h 28m2 stops
$314
Find Deal
Sun, Oct 5 - Wed, Oct 8

Spirit Airlines flights from Milwaukee to South Carolina

Our best Spirit Airlines deals on Milwaukee to South Carolina flight tickets
Spirit Airlines
Oct 5
MKE1:55 pmMilwaukee-Mitchell
16h 52m
1 stop
CLT7:47 amCharlotte Douglas
Oct 8
CLT2:40 pmCharlotte Douglas
23h 02m
1 stop
MKE12:42 pmMilwaukee-Mitchell
$275
Find similar
Spirit Airlines
Oct 12
MKE1:55 pmMilwaukee-Mitchell
7h 33m
1 stop
CLT10:28 pmCharlotte Douglas
Oct 15
CLT6:00 amCharlotte Douglas
31h 42m
2 stops
MKE12:42 pmMilwaukee-Mitchell
$313
Find similar
Spirit Airlines
Oct 12
MKE1:55 pmMilwaukee-Mitchell
7h 33m
1 stop
CLT10:28 pmCharlotte Douglas
Oct 18
CLT10:06 pmCharlotte Douglas
15h 36m
1 stop
MKE12:42 pmMilwaukee-Mitchell
$318
Find similar

American Airlines flights from Milwaukee to South Carolina

Our best American Airlines deals on Milwaukee to South Carolina flight tickets
American Airlines
Oct 28
MKE6:45 amMilwaukee-Mitchell
5h 55m
2 stops
GSP1:40 pmGreenville
Oct 28
GSP7:11 pmGreenville
5h 19m
1 stop
MKE11:30 pmMilwaukee-Mitchell
$248
Find similar
American Airlines
Feb 11
MKE1:22 pmMilwaukee-Mitchell
4h 55m
1 stop
MYR7:17 pmMyrtle Beach Intl
Feb 25
MYR2:55 pmMyrtle Beach Intl
7h 01m
1 stop
MKE8:56 pmMilwaukee-Mitchell
$255
Find similar
American Airlines
Feb 11
MKE6:49 pmMilwaukee-Mitchell
3h 48m
1 stop
MYR11:37 pmMyrtle Beach Intl
Feb 25
MYR2:28 pmMyrtle Beach Intl
7h 28m
2 stops
MKE8:56 pmMilwaukee-Mitchell
$260
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Milwaukee to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 7, 2025.
Use the filters below to find and compare flights from Milwaukee to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MilwaukeeGreenville

MKE - GSP

MKEGSP

Milwaukee-Mitchell

Tue 10/28

6:05 am-11:47 am

1 stop4h 42m

Greenville

Tue 10/28

5:28 pm-10:43 pm

1 stop6h 15m

$243

MilwaukeeGreenville

MKE - GSP

MKEGSP

Milwaukee-Mitchell

Tue 10/28

6:45 am-1:40 pm

2 stops5h 55m

Greenville

Tue 10/28

7:11 pm-11:30 pm

1 stop5h 19m

$248

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Sat 10/18

12:06 pm-8:01 pm

1 stop6h 55m

Columbia Metropolitan

Mon 10/20

7:55 pm-11:55 pm

1 stop5h 00m

$249

MilwaukeeGreenville

MKE - GSP

MKEGSP

Milwaukee-Mitchell

Sat 2/28

5:00 pm-10:05 pm

1 stop4h 05m

Greenville

Wed 3/4

5:45 am-11:18 am

1 stop6h 33m

$250

MilwaukeeSavannah

MKE - SAV

MKESAV

Milwaukee-Mitchell

Sat 10/4

2:05 pm-7:40 pm

1 stop4h 35m

Savannah/Hilton Head

Tue 10/7

7:35 pm-10:25 pm

1 stop3h 50m

$263

MilwaukeeSavannah

MKE - SAV

MKESAV

Milwaukee-Mitchell

Fri 11/7

5:10 pm-10:55 pm

1 stop4h 45m

Savannah/Hilton Head

Tue 11/11

5:35 pm-9:45 pm

1 stop5h 10m

$266

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Sun 10/5

1:55 pm-7:47 am

1 stop16h 52m

Charlotte Douglas

Wed 10/8

2:40 pm-12:42 pm

1 stop23h 02m

$275

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Thu 10/30

1:55 pm-7:47 am

1 stop16h 52m

Charlotte Douglas

Sun 11/2

6:07 pm-7:19 pm

1 stop26h 12m

$299

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Sun 10/12

1:55 pm-10:28 pm

1 stop7h 33m

Charlotte Douglas

Wed 10/15

6:00 am-12:42 pm

2 stops31h 42m

$313

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Sun 10/5

1:55 pm-7:47 am

1 stop16h 52m

Charlotte Douglas

Wed 10/8

2:14 pm-12:42 pm

2 stops23h 28m

$314

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Milwaukee to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Milwaukee is in September. Flight prices, which tend to average around $339, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Milwaukee during February instead. Flights to South Carolina in February, while not as cheap as those in September, still average around $341.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Tuesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $327. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $454.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Milwaukee to South Carolina flights are usually those with departure times at noon. Our users have found flights to South Carolina at noon for as low as $348. Try not to purchase tickets in the morning because they tend to be around $381. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Milwaukee when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $371 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Milwaukee for as low as $265 on momondo.

Cheap Milwaukee to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Milwaukee to South Carolina

Fastest flight time

2h 06m

Direct flights

Every day

Airports in South Carolina

1 airport
The fastest flight from Milwaukee to South Carolina takes 2h 06m
Direct flights go from Milwaukee to South Carolina every day.
There is 1 airport near South Carolina: Charlotte Douglas (CLT)
Search flight deals

  • When did momondo last update prices for flights from Milwaukee-Mitchell Airport to South Carolina?

    Prices for flights from Milwaukee-Mitchell Airport to South Carolina are refreshed on a daily basis.

  • How many operators does momondo search for flights from Milwaukee-Mitchell Airport to South Carolina?

  • How old do you have to be to fly from Milwaukee-Mitchell Airport to South Carolina?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Milwaukee-Mitchell Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The necessary travel and health documents for your South Carolina trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Milwaukee to South Carolina

Compare and see reviews for airlines that fly from Milwaukee to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $141Free CancellationRating
6.3
8,022 reviews
Search Spirit Airlines flights
American AirlinesPriceFrom $228Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $228Free CancellationRating
7.9
7,972 reviews
Search Delta flights
SouthwestPriceFrom $256Free CancellationRating
8.0
4,247 reviews
Search Southwest flights
United AirlinesPriceFrom $280Free CancellationRating
7.4
8,939 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Milwaukee to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Milwaukee to South Carolina for you.

Can I find flights from Milwaukee to South Carolina with flexible booking policies on momondo?

Yes. All flights to South Carolina from Milwaukee on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Milwaukee to South Carolina?

momondo provides multiple filters to help you find the best flight to South Carolina from Milwaukee. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Milwaukee to South Carolina right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Milwaukee to South Carolina flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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