How many flights depart from Milwaukee to South Carolina on average per week?

The number of flights available between Milwaukee and South Carolina is 3 per week as of October 2026. The most frequent departure day is Mon, with 33% of weekly flights leaving on this day.

What airlines fly to South Carolina?

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to South Carolina from Milwaukee according to our data. American Airlines is the first choice among our users, with 50% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Milwaukee-Mitchell to South Carolina?

United Airlines, American Airlines, and Delta are the most popular carriers operating from Milwaukee-Mitchell to South Carolina

When did momondo last update prices for flights from Milwaukee-Mitchell Airport to South Carolina?

Prices for flights from Milwaukee-Mitchell Airport to South Carolina are refreshed on a daily basis.

How many operators does momondo search for flights from Milwaukee-Mitchell Airport to South Carolina?

As of October 2026, there are 4 operators available to choose from for flights from Milwaukee-Mitchell Airport to South Carolina.

How old do you have to be to fly from Milwaukee-Mitchell Airport to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Milwaukee-Mitchell Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The necessary travel and health documents for your South Carolina trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$130 Cheap Flights from Milwaukee to South Carolina in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Milwaukee to South Carolina

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

11:38 am - 6:06 pmMKE Milwaukee-Mitchell-GSP Greenville

5h 28m1 stop Chicago O'Hare Intl

4:37 pm - 10:37 pmGSP Greenville-MKE Milwaukee-Mitchell

7h 00m1 stop Chicago O'Hare Intl

$259American Airlines

Wed, Nov 11 - Mon, Nov 16

8:40 am - 4:07 pmMKE Milwaukee-Mitchell-GSP Greenville

6h 27m1 stop Chicago O'Hare Intl

7:41 pm - 11:06 pmGSP Greenville-MKE Milwaukee-Mitchell

4h 25m1 stop Charlotte Douglas

$259American Airlines

Tue, Nov 10 - Tue, Nov 17

2:38 pm - 8:59 pmMKE Milwaukee-Mitchell-GSP Greenville

5h 21m1 stop Chicago O'Hare Intl

2:04 pm - 6:48 pmGSP Greenville-MKE Milwaukee-Mitchell

5h 44m1 stop Chicago O'Hare Intl

$259United Airlines

Tue, Dec 1 - Tue, Dec 8

3:33 pm - 8:58 pmMKE Milwaukee-Mitchell-GSP Greenville

4h 25m1 stop Chicago O'Hare Intl

5:40 am - 10:23 amGSP Greenville-MKE Milwaukee-Mitchell

5h 43m1 stop Newark

$259United Airlines

Tue, Nov 3 - Tue, Nov 10

6:20 am - 2:10 pmMKE Milwaukee-Mitchell-GSP Greenville

6h 50m2 stops Chicago Midway Nashville Intl

6:45 pm - 10:20 pmGSP Greenville-MKE Milwaukee-Mitchell

4h 35m1 stop Nashville Intl

$264Southwest

Wed, Nov 11 - Mon, Nov 16

6:20 am - 2:10 pmMKE Milwaukee-Mitchell-GSP Greenville

6h 50m2 stops Chicago Midway Nashville Intl

2:50 pm - 9:20 pmGSP Greenville-MKE Milwaukee-Mitchell

7h 30m1 stop Baltimore/Washington

$264Southwest

Tue, Dec 1 - Tue, Dec 8

7:00 am - 1:15 pmMKE Milwaukee-Mitchell-GSP Greenville

5h 15m1 stop Atlanta Hartsfield-Jackson

7:00 am - 11:48 amGSP Greenville-MKE Milwaukee-Mitchell

5h 48m1 stop Atlanta Hartsfield-Jackson

$277Delta

Tue, Nov 24 - Tue, Dec 1

12:42 pm - 6:19 pmMKE Milwaukee-Mitchell-GSP Greenville

4h 37m1 stop Atlanta Hartsfield-Jackson

8:11 am - 11:37 amGSP Greenville-MKE Milwaukee-Mitchell

4h 26m1 stop Atlanta Hartsfield-Jackson

$277Delta

Tue, Nov 17 - Tue, Nov 24

6:13 pm - 10:05 amMKE Milwaukee-Mitchell-MYR Myrtle Beach Intl

14h 52m1 stop Orlando

2:41 pm - 4:38 pmMYR Myrtle Beach Intl-MKE Milwaukee-Mitchell

26h 57m1 stop Orlando

$303Multiple Airlines

Mon, Dec 7 - Mon, Dec 21

6:13 pm - 2:17 pmMKE Milwaukee-Mitchell-MYR Myrtle Beach Intl

43h 04m2 stops Orlando Akron/Canton

2:41 pm - 4:38 pmMYR Myrtle Beach Intl-MKE Milwaukee-Mitchell

26h 57m1 stop Orlando

$407Multiple Airlines

Mon, Dec 7 - Mon, Dec 21

Cheap last minute flights

Enter your travel dates to find the best prices.

12:36 pm - 6:34 pmMKE Milwaukee-Mitchell-CAE Columbia Metropolitan

4h 58m1 stop Atlanta Hartsfield-Jackson

5:40 am - 9:11 amCAE Columbia Metropolitan-MKE Milwaukee-Mitchell

4h 31m1 stop Atlanta Hartsfield-Jackson

$463Delta

Fri, Oct 23 - Wed, Oct 28

2:20 pm - 9:09 pmMKE Milwaukee-Mitchell-CAE Columbia Metropolitan

5h 49m1 stop Chicago O'Hare Intl

10:29 am - 1:43 pmCAE Columbia Metropolitan-MKE Milwaukee-Mitchell

4h 14m1 stop Chicago O'Hare Intl

$483United Airlines

Fri, Oct 23 - Sat, Oct 24

2:20 pm - 9:09 pmMKE Milwaukee-Mitchell-CAE Columbia Metropolitan

5h 49m1 stop Chicago O'Hare Intl

3:03 pm - 11:37 pmCAE Columbia Metropolitan-MKE Milwaukee-Mitchell

9h 34m2 stops Washington, D.C. Dulles Intl Newark

$489United Airlines

Fri, Oct 23 - Sat, Oct 24

2:20 pm - 9:09 pmMKE Milwaukee-Mitchell-CAE Columbia Metropolitan

5h 49m1 stop Chicago O'Hare Intl

12:21 pm - 6:58 pmCAE Columbia Metropolitan-MKE Milwaukee-Mitchell

7h 37m2 stops Newark Chicago O'Hare Intl

$505United Airlines

Fri, Oct 23 - Wed, Oct 28

6:02 pm - 11:56 pmMKE Milwaukee-Mitchell-CHS Charleston

4h 54m1 stop Philadelphia

3:33 pm - 8:27 pmCHS Charleston-MKE Milwaukee-Mitchell

5h 54m1 stop Charlotte Douglas

$630American Airlines

Thu, Oct 22 - Tue, Oct 27

5:30 am - 11:35 amMKE Milwaukee-Mitchell-CHS Charleston

5h 05m1 stop Atlanta Hartsfield-Jackson

7:10 am - 12:44 pmCHS Charleston-MKE Milwaukee-Mitchell

6h 34m1 stop Detroit Metropolitan Wayne County

$646Delta

Thu, Oct 22 - Tue, Oct 27

8:05 pm - 12:40 pmMKE Milwaukee-Mitchell-CHS Charleston

15h 35m2 stops Orlando Nashville Intl

2:20 pm - 9:50 pmCHS Charleston-MKE Milwaukee-Mitchell

8h 30m2 stops Dallas Love Field Denver Intl

$655Southwest

Fri, Oct 23 - Wed, Oct 28

6:02 pm - 11:56 pmMKE Milwaukee-Mitchell-CHS Charleston

4h 54m1 stop Philadelphia

8:10 am - 2:24 pmCHS Charleston-MKE Milwaukee-Mitchell

7h 14m2 stops Charlotte Douglas Chicago O'Hare Intl

$660American Airlines

Thu, Oct 22 - Tue, Oct 27

4:29 pm - 10:51 pmMKE Milwaukee-Mitchell-CHS Charleston

5h 22m1 stop Atlanta Hartsfield-Jackson

6:00 am - 11:34 amCHS Charleston-MKE Milwaukee-Mitchell

6h 34m1 stop Atlanta Hartsfield-Jackson

$675Delta

Sun, Oct 18 - Sat, Oct 24

5:00 am - 4:10 pmMKE Milwaukee-Mitchell-CHS Charleston

10h 10m2 stops Orlando Nashville Intl

2:10 pm - 8:25 pmCHS Charleston-MKE Milwaukee-Mitchell

7h 15m1 stop Denver Intl

$680Southwest

Mon, Oct 19 - Sat, Oct 24

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Southwest flights from Milwaukee to South Carolina

Our best Southwest deals on Milwaukee to South Carolina flight tickets

Southwest

Nov 10

MKE6:20 amMilwaukee-Mitchell

6h 50m

2 stops

GSP2:10 pmGreenville

Nov 17

GSP7:05 amGreenville

9h 35m

2 stops

MKE3:40 pmMilwaukee-Mitchell

$269

Southwest

Nov 3

MKE8:00 amMilwaukee-Mitchell

9h 10m

2 stops

GSP6:10 pmGreenville

Nov 10

GSP7:05 amGreenville

8h 00m

2 stops

MKE2:05 pmMilwaukee-Mitchell

$275

Southwest

Nov 17

MKE6:20 amMilwaukee-Mitchell

5h 55m

2 stops

MYR1:15 pmMyrtle Beach Intl

Nov 24

MYR7:15 pmMyrtle Beach Intl

5h 25m

1 stop

MKE11:40 pmMilwaukee-Mitchell

$330

Delta flights from Milwaukee to South Carolina

Our best Delta deals on Milwaukee to South Carolina flight tickets

Delta

Nov 17

MKE12:42 pmMilwaukee-Mitchell

4h 37m

1 stop

GSP6:19 pmGreenville

Nov 24

GSP8:11 amGreenville

4h 26m

1 stop

MKE11:37 amMilwaukee-Mitchell

$277

Delta

Nov 16

MKE5:20 amMilwaukee-Mitchell

7h 13m

1 stop

MYR1:33 pmMyrtle Beach Intl

Nov 23

MYR6:51 pmMyrtle Beach Intl

6h 03m

1 stop

MKE11:54 pmMilwaukee-Mitchell

$325

Delta

Mar 31

MKE7:00 amMilwaukee-Mitchell

5h 13m

1 stop

CAE1:13 pmColumbia Metropolitan

Apr 4

CAE5:40 amColumbia Metropolitan

4h 42m

1 stop

MKE9:22 amMilwaukee-Mitchell

$329

momondo Fare Finder

Use the filters below to find and compare flights from Milwaukee to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MilwaukeeGreenville

MKE Milwaukee-Mitchell - GSP Greenville

MKEGSP

Milwaukee-Mitchell

Wed 11/11

11:38 am-6:06 pm

1 stop5h 28m

Greenville

Mon 11/16

4:37 pm-10:37 pm

1 stop7h 00m

$259

MilwaukeeGreenville

MKE Milwaukee-Mitchell - GSP Greenville

MKEGSP

Milwaukee-Mitchell

Tue 11/10

8:40 am-4:07 pm

1 stop6h 27m

Greenville

Tue 11/17

7:41 pm-11:06 pm

1 stop4h 25m

$259

MilwaukeeGreenville

MKE Milwaukee-Mitchell - GSP Greenville

MKEGSP

Milwaukee-Mitchell

Tue 12/1

2:38 pm-8:59 pm

1 stop5h 21m

Greenville

Tue 12/8

2:04 pm-6:48 pm

1 stop5h 44m

$259

MilwaukeeGreenville

MKE Milwaukee-Mitchell - GSP Greenville

MKEGSP

Milwaukee-Mitchell

Tue 11/3

3:33 pm-8:58 pm

1 stop4h 25m

Greenville

Tue 11/10

5:40 am-10:23 am

1 stop5h 43m

$259

MilwaukeeGreenville

MKE Milwaukee-Mitchell - GSP Greenville

MKEGSP

Milwaukee-Mitchell

Wed 11/11

6:20 am-2:10 pm

2 stops6h 50m

Greenville

Mon 11/16

6:45 pm-10:20 pm

1 stop4h 35m

$264

MilwaukeeGreenville

MKE Milwaukee-Mitchell - GSP Greenville

MKEGSP

Milwaukee-Mitchell

Tue 12/1

6:20 am-2:10 pm

2 stops6h 50m

Greenville

Tue 12/8

2:50 pm-9:20 pm

1 stop7h 30m

$264

MilwaukeeGreenville

MKE Milwaukee-Mitchell - GSP Greenville

MKEGSP

Milwaukee-Mitchell

Tue 11/24

7:00 am-1:15 pm

1 stop5h 15m

Greenville

Tue 12/1

7:00 am-11:48 am

1 stop5h 48m

$277

Quickest round-trip

MilwaukeeGreenville

MKE Milwaukee-Mitchell - GSP Greenville

MKEGSP

Milwaukee-Mitchell

Tue 11/17

12:42 pm-6:19 pm

1 stop4h 37m

Greenville

Tue 11/24

8:11 am-11:37 am

1 stop4h 26m

$277

MilwaukeeMyrtle Beach

MKE Milwaukee-Mitchell - MYR Myrtle Beach Intl

MKEMYR

Milwaukee-Mitchell

Mon 12/7

6:13 pm-10:05 am

1 stop14h 52m

Myrtle Beach Intl

Mon 12/21

2:41 pm-4:38 pm

1 stop26h 57m

$303

MilwaukeeMyrtle Beach

MKE Milwaukee-Mitchell - MYR Myrtle Beach Intl

MKEMYR

Milwaukee-Mitchell

Mon 12/7

6:13 pm-2:17 pm

2 stops43h 04m

Myrtle Beach Intl

Mon 12/21

2:41 pm-4:38 pm

1 stop26h 57m

$407

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Milwaukee to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Milwaukee is in November. Flight prices, which tend to average around $352, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of November, then book flights to South Carolina from Milwaukee during February instead. Flights to South Carolina in February, while not as cheap as those in November, still average around $357.

How far in advance should I book a flight from Milwaukee to South Carolina?

You are more likely to see cheaper flights to South Carolina from Milwaukee when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $413 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Milwaukee for as low as $361 on momondo.

Cheap Milwaukee to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Milwaukee to South Carolina

Best Price Found	$130
Fastest flight time	2h 03m
Direct flights	None

The best one-way flight to South Carolina from Milwaukee in the past 72 hours is $130. The best round-trip flight deal from Milwaukee to South Carolina found on momondo in the last 72 hours is $259.

The fastest flight from Milwaukee to South Carolina takes 2h 03m

There are no direct flights from Milwaukee to South Carolina. There are no popular flight routes from Milwaukee to South Carolina.

Search flight deals

Frequently asked questions about flying from Milwaukee to South Carolina

When did momondo last update prices for flights from Milwaukee-Mitchell Airport to South Carolina?
Prices for flights from Milwaukee-Mitchell Airport to South Carolina are refreshed on a daily basis.
How many operators does momondo search for flights from Milwaukee-Mitchell Airport to South Carolina?
As of October 2026, there are 4 operators available to choose from for flights from Milwaukee-Mitchell Airport to South Carolina.
How old do you have to be to fly from Milwaukee-Mitchell Airport to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Milwaukee-Mitchell Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The necessary travel and health documents for your South Carolina trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Milwaukee to South Carolina

Compare and see reviews for airlines that fly from Milwaukee to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $203	Free Cancellation	Rating 7.0 12,177 reviews	Search American Airlines flights
Delta	PriceFrom $216	Free Cancellation	Rating 7.8 8,663 reviews	Search Delta flights
United Airlines	PriceFrom $248	Free Cancellation	Rating 7.4 10,382 reviews	Search United Airlines flights
Southwest	PriceFrom $290	Free Cancellation	Rating 7.9 4,216 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Milwaukee to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Milwaukee to South Carolina for you.

Can I find flights from Milwaukee to South Carolina with flexible booking policies on momondo?

Yes. All flights to South Carolina from Milwaukee on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Milwaukee to South Carolina?

momondo provides multiple filters to help you find the best flight to South Carolina from Milwaukee. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Milwaukee to South Carolina right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Milwaukee to South Carolina flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.